-- dump date 20111111_072859 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type NP_009332.1 6319249 851229 complement(1807..2169) 1 NC_001133.7 Pau8p 2169 PAU8 851229 PAU8 Saccharomyces cerevisiae Pau8p NP_009332.1 1807 R 4932 CDS NP_878038.1 33438754 1466426 2480..2707 1 NC_001133.7 Yal067w-ap; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 2707 1466426 YAL067W-A Saccharomyces cerevisiae Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching NP_878038.1 2480 D 4932 CDS NP_009333.1 6319250 851230 complement(7236..9017) 1 NC_001133.7 Seo1p; Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide 9017 SEO1 851230 SEO1 Saccharomyces cerevisiae Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide NP_009333.1 7236 R 4932 CDS NP_009335.1 6319252 851232 complement(11566..11952) 1 NC_001133.7 Yal065cp; Putative protein of unknown function; has homology to FLO1; possible pseudogene 11952 851232 YAL065C Saccharomyces cerevisiae Putative protein of unknown function; has homology to FLO1; possible pseudogene NP_009335.1 11566 R 4932 CDS NP_009336.1 6319253 851233 12047..12427 1 NC_001133.7 Yal064w-bp; Fungal-specific protein of unknown function 12427 851233 YAL064W-B Saccharomyces cerevisiae Fungal-specific protein of unknown function NP_009336.1 12047 D 4932 CDS NP_058136.1 7839146 851234 complement(13364..13744) 1 NC_001133.7 Yal064c-ap; Putative protein of unknown function; YAL064C-A is not an essential gene 13744 851234 YAL064C-A Saccharomyces cerevisiae Putative protein of unknown function; YAL064C-A is not an essential gene NP_058136.1 13364 R 4932 CDS NP_009337.1 6319254 851235 21526..21852 1 NC_001133.7 Yal064wp; Protein of unknown function; may interact with ribosomes, based on co-purification experiments 21852 851235 YAL064W Saccharomyces cerevisiae Protein of unknown function; may interact with ribosomes, based on co-purification experiments NP_009337.1 21526 D 4932 CDS NP_878039.1 33438755 1466427 complement(22397..22687) 1 NC_001133.7 Yal063c-ap; Putative protein of unknown function; identified by expression profiling and mass spectrometry 22687 1466427 YAL063C-A Saccharomyces cerevisiae Putative protein of unknown function; identified by expression profiling and mass spectrometry NP_878039.1 22397 R 4932 CDS NP_009338.1 6319255 851236 complement(24001..27969) 1 NC_001133.7 Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation; Flo9p 27969 FLO9 851236 FLO9 Saccharomyces cerevisiae Flo9p NP_009338.1 24001 R 4932 CDS NP_009339.1 6319256 851237 31568..32941 1 NC_001133.7 NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; Gdh3p 32941 GDH3 851237 GDH3 Saccharomyces cerevisiae Gdh3p NP_009339.1 31568 D 4932 CDS NP_009340.1 6319257 851238 33449..34702 1 NC_001133.7 Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; BDH2 is an essential gene; Bdh2p 34702 BDH2 851238 BDH2 Saccharomyces cerevisiae Bdh2p NP_009340.1 33449 D 4932 CDS NP_009341.1 6319258 851239 35156..36304 1 NC_001133.7 NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source; Bdh1p 36304 BDH1 851239 BDH1 Saccharomyces cerevisiae Bdh1p NP_009341.1 35156 D 4932 CDS NP_009342.1 6319259 851240 36510..37148 1 NC_001133.7 Protein of unknown function, localized in the nucleoplasm and the nucleolus, genetically interacts with MTR2 in 60S ribosomal protein subunit export; Ecm1p 37148 ECM1 851240 ECM1 Saccharomyces cerevisiae Ecm1p NP_009342.1 36510 D 4932 CDS NP_009343.1 6319260 851241 37465..38973 1 NC_001133.7 Cne1p; Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast 38973 CNE1 851241 CNE1 Saccharomyces cerevisiae Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast NP_009343.1 37465 D 4932 CDS NP_009345.2 41629666 851243 39260..41902 1 NC_001133.7 Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb1p; Gpb2p 41902 GPB2 851243 GPB2 Saccharomyces cerevisiae Gpb2p NP_009345.2 39260 D 4932 CDS NP_009346.1 6319263 851244 42178..42720 1 NC_001133.7 Putative peroxisomal membrane protein required for import of peroxisomal proteins, functionally complements a Pichia pastoris pex22 mutation; Pex22p 42720 PEX22 851244 PEX22 Saccharomyces cerevisiae Pex22p NP_009346.1 42178 D 4932 CDS NP_009347.1 6319264 851245 complement(42882..45023) 1 NC_001133.7 Acs1p; Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions 45023 ACS1 851245 ACS1 Saccharomyces cerevisiae Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions NP_009347.1 42882 R 4932 CDS NP_009348.1 6319265 851246 45900..48251 1 NC_001133.7 Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; Flc2p 48251 FLC2 851246 FLC2 Saccharomyces cerevisiae Flc2p NP_009348.1 45900 D 4932 CDS NP_009349.2 50593114 851247 48565..51708 1 NC_001133.7 Oleate-activated transcription factor, acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; Oaf1p 51708 OAF1 851247 OAF1 Saccharomyces cerevisiae Oaf1p NP_009349.2 48565 D 4932 CDS NP_009350.1 6319267 851248 complement(51856..52596) 1 NC_001133.7 Cytoplasmic protein of unknown function, potential Hsp82p interactor; null mutant displays decreased frequency of mitochondrial genome loss (petite formation); Aim2p 52596 AIM2 851248 AIM2 Saccharomyces cerevisiae Aim2p NP_009350.1 51856 R 4932 CDS NP_009351.1 6319268 851249 complement(52802..54790) 1 NC_001133.7 Gem1p; Evolutionarily-conserved tail-anchored outer mitochondrial membrane GTPase which regulates mitochondrial morphology; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; not required for pheromone-induced cell death 54790 GEM1 851249 GEM1 Saccharomyces cerevisiae Evolutionarily-conserved tail-anchored outer mitochondrial membrane GTPase which regulates mitochondrial morphology; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; not required for pheromone-induced cell death NP_009351.1 52802 R 4932 CDS NP_009352.1 6319269 851250 complement(54990..56858) 1 NC_001133.7 Spc72p; Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization 56858 SPC72 851250 SPC72 Saccharomyces cerevisiae Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization NP_009352.1 54990 R 4932 CDS NP_009353.1 6319270 851251 complement(57030..57386) 1 NC_001133.7 Putative protein of unknown function; null mutant displays increased frequency of mitochondrial genome loss (petite formation); Aim1p 57386 AIM1 851251 AIM1 Saccharomyces cerevisiae Aim1p NP_009353.1 57030 R 4932 CDS NP_075206.1 12621476 851252 57519..57851 1 NC_001133.7 Yal044w-ap; Putative protein of unknown function; similar to S. pombe uvi31 which is a putative DNA repair protein 57851 851252 YAL044W-A Saccharomyces cerevisiae Putative protein of unknown function; similar to S. pombe uvi31 which is a putative DNA repair protein NP_075206.1 57519 D 4932 CDS NP_009355.2 37362609 851254 complement(57951..58463) 1 NC_001133.7 H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm; Gcv3p 58463 GCV3 851254 GCV3 Saccharomyces cerevisiae Gcv3p NP_009355.2 57951 R 4932 CDS NP_009356.1 6319273 851255 complement(58696..61053) 1 NC_001133.7 Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII; Pta1p 61053 PTA1 851255 PTA1 Saccharomyces cerevisiae Pta1p NP_009356.1 58696 R 4932 CDS NP_009358.1 6319274 851256 61317..62564 1 NC_001133.7 Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport; Erv46p 62564 ERV46 851256 ERV46 Saccharomyces cerevisiae Erv46p NP_009358.1 61317 D 4932 CDS NP_009359.1 6319276 851190 62841..65405 1 NC_001133.7 Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing; Cdc24p 65405 CDC24 851190 CDC24 Saccharomyces cerevisiae Cdc24p NP_009359.1 62841 D 4932 CDS NP_009360.1 6319277 851191 complement(65779..67521) 1 NC_001133.7 G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis; Cln3p 67521 CLN3 851191 CLN3 Saccharomyces cerevisiae Cln3p NP_009360.1 65779 R 4932 CDS NP_009361.1 6319278 851192 complement(68717..69526) 1 NC_001133.7 Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS); Cyc3p 69526 CYC3 851192 CYC3 Saccharomyces cerevisiae Cyc3p NP_009361.1 68717 R 4932 CDS NP_009362.1 6319279 851193 71787..73289 1 NC_001133.7 Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; Cdc19p 73289 CDC19 851193 CDC19 Saccharomyces cerevisiae Cdc19p NP_009362.1 71787 D 4932 CDS NP_878040.1 33438756 1466428 complement(73427..73519) 1 NC_001133.7 Yal037c-ap; Putative protein of unknown function 73519 1466428 YAL037C-A Saccharomyces cerevisiae Putative protein of unknown function NP_878040.1 73427 R 4932 CDS NP_009363.1 6319280 851194 74021..74824 1 NC_001133.7 Yal037wp; Putative protein of unknown function 74824 851194 YAL037W Saccharomyces cerevisiae Putative protein of unknown function NP_009363.1 74021 D 4932 CDS NP_009364.1 6319281 851195 complement(75044..76153) 1 NC_001133.7 Rbg1p; Member of the DRG family of GTP-binding proteins; interacts with translating ribosomes and with Tma46p 76153 RBG1 851195 RBG1 Saccharomyces cerevisiae Member of the DRG family of GTP-binding proteins; interacts with translating ribosomes and with Tma46p NP_009364.1 75044 R 4932 CDS NP_009365.1 6319282 851196 76428..79436 1 NC_001133.7 GTPase, required for general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; homolog of bacterial IF2; Fun12p 79436 FUN12 851196 FUN12 Saccharomyces cerevisiae Fun12p NP_009365.1 76428 D 4932 CDS NP_009367.1 6319283 851197 79719..80588 1 NC_001133.7 Mtw1p; Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly 80588 MTW1 851197 MTW1 Saccharomyces cerevisiae Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly NP_009367.1 79719 D 4932 CDS NP_009368.2 37362610 851199 complement(80711..81952) 1 NC_001133.7 Non-essential protein of unknown function; Fun19p 81952 FUN19 851199 FUN19 Saccharomyces cerevisiae Fun19p NP_009368.2 80711 R 4932 CDS NP_009369.1 6319286 851200 82707..83228 1 NC_001133.7 Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; Pop5p 83228 POP5 851200 POP5 Saccharomyces cerevisiae Pop5p NP_009369.1 82707 D 4932 CDS NP_009370.1 6319287 851201 complement(83336..84475) 1 NC_001133.7 Prp45p; Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene 84475 PRP45 851201 PRP45 Saccharomyces cerevisiae Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene NP_009370.1 83336 R 4932 CDS NP_009371.1 6319288 851202 complement(84750..87032) 1 NC_001133.7 Gip4p; Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate 87032 GIP4 851202 GIP4 Saccharomyces cerevisiae Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate NP_009371.1 84750 R 4932 CDS NP_009372.1 6319289 851203 join(87287..87388,87502..87753) 1 NC_001133.7 Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; Snc1p 87753 SNC1 851203 SNC1 Saccharomyces cerevisiae Snc1p NP_009372.1 87287 D 4932 CDS NP_009373.1 6319290 851204 complement(87856..92271) 1 NC_001133.7 One of two type V myosin motors (along with MYO2) involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p; Myo4p 92271 MYO4 851204 MYO4 Saccharomyces cerevisiae Myo4p NP_009373.1 87856 R 4932 CDS NP_009374.1 6319291 851205 92901..94487 1 NC_001133.7 Tail-anchored endoplasmic reticulum membrane protein, interacts with homolog Frt1p but is not a substrate of calcineurin (unlike Frt1p), promotes growth in conditions of high Na+, alkaline pH, or cell wall stress; potential Cdc28p substrate; Frt2p 94487 FRT2 851205 FRT2 Saccharomyces cerevisiae Frt2p NP_009374.1 92901 D 4932 CDS NP_009375.1 6319292 851206 94688..95473 1 NC_001133.7 Saw1p; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YAL027W is a non-essential gene 95473 SAW1 851206 SAW1 Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YAL027W is a non-essential gene NP_009375.1 94688 D 4932 CDS NP_009376.1 6319293 851207 complement(95631..99698) 1 NC_001133.7 Drs2p; Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vessicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease 99698 DRS2 851207 DRS2 Saccharomyces cerevisiae Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vessicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease NP_009376.1 95631 R 4932 CDS NP_009377.1 6319294 851208 complement(100226..101146) 1 NC_001133.7 Mak16p; Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus 101146 MAK16 851208 MAK16 Saccharomyces cerevisiae Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus NP_009377.1 100226 R 4932 CDS NP_009378.1 6319295 851209 complement(101566..105873) 1 NC_001133.7 Putative GDP/GTP exchange factor required for mitotic exit at low temperatures; acts as a guanine nucleotide exchange factor (GEF) for Tem1p, which is a key regulator of mitotic exit; physically associates with Ras2p-GTP; Lte1p 105873 LTE1 851209 LTE1 Saccharomyces cerevisiae Lte1p NP_009378.1 101566 R 4932 CDS NP_009379.2 27469358 851210 complement(106273..108552) 1 NC_001133.7 Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt1p, can instead interact with Pmt5p in some conditions; target for new antifungals; Pmt2p 108552 PMT2 851210 PMT2 Saccharomyces cerevisiae Pmt2p NP_009379.2 106273 R 4932 CDS NP_009380.1 6319297 851211 complement(108878..110431) 1 NC_001133.7 Nucleoside transporter with broad nucleoside selectivity; localized to intracellular membranes; Fun26p 110431 FUN26 851211 FUN26 Saccharomyces cerevisiae Fun26p NP_009380.1 108878 R 4932 CDS NP_009381.1 6319298 851212 complement(110847..113360) 1 NC_001133.7 Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening; Ccr4p 113360 CCR4 851212 CCR4 Saccharomyces cerevisiae Ccr4p NP_009381.1 110847 R 4932 CDS NP_009382.1 6319299 851213 complement(113615..114616) 1 NC_001133.7 Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle; Ats1p 114616 ATS1 851213 ATS1 Saccharomyces cerevisiae Ats1p NP_009382.1 113615 R 4932 CDS NP_009383.1 6319300 851214 114920..118315 1 NC_001133.7 Protein whose overexpression affects chromosome stability, potential Cdc28p substrate; homolog of Snf2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Fun30p 118315 FUN30 851214 FUN30 Saccharomyces cerevisiae Fun30p NP_009383.1 114920 D 4932 CDS NP_009384.1 6319301 851215 complement(118565..119542) 1 NC_001133.7 Yal018cp; Putative protein of unknown function 119542 851215 YAL018C Saccharomyces cerevisiae Putative protein of unknown function NP_009384.1 118565 R 4932 CDS NP_009385.1 6319302 851216 120226..124296 1 NC_001133.7 Psk1p; One of two (see also PSK2) PAS domain containing S/T protein kinases; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status 124296 PSK1 851216 PSK1 Saccharomyces cerevisiae One of two (see also PSK2) PAS domain containing S/T protein kinases; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status NP_009385.1 120226 D 4932 CDS NP_009386.1 6319303 851217 124880..126787 1 NC_001133.7 Tpd3p; Regulatory subunit A of the heterotrimeric protein phosphatase 2A, which also contains regulatory subunit Cdc55p and either catalytic subunit Pph21p or Pph22p; required for cell morphogenesis and for transcription by RNA polymerase III 126787 TPD3 851217 TPD3 Saccharomyces cerevisiae Regulatory subunit A of the heterotrimeric protein phosphatase 2A, which also contains regulatory subunit Cdc55p and either catalytic subunit Pph21p or Pph22p; required for cell morphogenesis and for transcription by RNA polymerase III NP_009386.1 124880 D 4932 CDS NP_009387.1 6319304 851218 complement(126904..128103) 1 NC_001133.7 Ntg1p; DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair, localizes to the nucleus and mitochondrion 128103 NTG1 851218 NTG1 Saccharomyces cerevisiae DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair, localizes to the nucleus and mitochondrion NP_009387.1 126904 R 4932 CDS NP_009388.2 27469359 851219 complement(128253..129020) 1 NC_001133.7 Syn8p; Endosomal SNARE related to mammalian syntaxin 8 129020 SYN8 851219 SYN8 Saccharomyces cerevisiae Endosomal SNARE related to mammalian syntaxin 8 NP_009388.2 128253 R 4932 CDS NP_009389.2 41629667 851220 129271..130533 1 NC_001133.7 Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation; Dep1p 130533 DEP1 851220 DEP1 Saccharomyces cerevisiae Dep1p NP_009389.2 129271 D 4932 CDS NP_009390.1 6319307 851221 130802..131986 1 NC_001133.7 Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine; Cys3p 131986 CYS3 851221 CYS3 Saccharomyces cerevisiae Cys3p NP_009390.1 130802 D 4932 CDS NP_009391.2 37362611 851222 132202..134079 1 NC_001133.7 Swc3p; Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae 134079 SWC3 851222 SWC3 Saccharomyces cerevisiae Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae NP_009391.2 132202 D 4932 CDS NP_009392.1 6319309 851223 complement(134186..135667) 1 NC_001133.7 Subunit of both the Mdm10-Mdm12-Mmm1 complex and the mitochondrial sorting and assembly machinery (SAM complex); functions in both the general and Tom40p-specific pathways for import and assembly of outer membrane beta-barrel proteins; Mdm10p 135667 MDM10 851223 MDM10 Saccharomyces cerevisiae Mdm10p NP_009392.1 134186 R 4932 CDS NP_009393.1 6319310 851224 135856..136635 1 NC_001133.7 Spo7p; Regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, which regulates nuclear growth by controlling recruitment of Pah1p onto promoters of phospholipid biosynthetic genes; required for normal nuclear envelope morphology and sporulation 136635 SPO7 851224 SPO7 Saccharomyces cerevisiae Regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, which regulates nuclear growth by controlling recruitment of Pah1p onto promoters of phospholipid biosynthetic genes; required for normal nuclear envelope morphology and sporulation NP_009393.1 135856 D 4932 CDS NP_009394.1 6319311 851225 136916..137512 1 NC_001133.7 Mitochondrial protein of unknown function; Fun14p 137512 FUN14 851225 FUN14 Saccharomyces cerevisiae Fun14p NP_009394.1 136916 D 4932 CDS NP_009395.1 6319312 851226 complement(137700..138347) 1 NC_001133.7 Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles; Erp2p 138347 ERP2 851226 ERP2 Saccharomyces cerevisiae Erp2p NP_009395.1 137700 R 4932 CDS NP_009396.2 144228166 851259 complement(139505..141433) 1 NC_001133.7 Ssa1p; ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and cell wall 141433 SSA1 851259 SSA1 Saccharomyces cerevisiae ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and cell wall NP_009396.2 139505 R 4932 CDS NP_009398.1 6319315 851260 join(142176..142255,142622..143162) 1 NC_001133.7 Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site; Efb1p 143162 EFB1 851260 EFB1 Saccharomyces cerevisiae Efb1p NP_009398.1 142176 D 4932 CDS NP_009399.2 41629668 851261 143709..147533 1 NC_001133.7 Vps8p; Membrane-associated protein that interacts with Vps21p to facilitate soluble vacuolar protein localization; component of the CORVET complex; required for localization and trafficking of the CPY sorting receptor; contains RING finger motif 147533 VPS8 851261 VPS8 Saccharomyces cerevisiae Membrane-associated protein that interacts with Vps21p to facilitate soluble vacuolar protein localization; component of the CORVET complex; required for localization and trafficking of the CPY sorting receptor; contains RING finger motif NP_009399.2 143709 D 4932 CDS NP_009400.1 6319317 851262 complement(join(147596..151008,151099..151168)) 1 NC_001133.7 Tfc3p; Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding 151168 TFC3 851262 TFC3 Saccharomyces cerevisiae Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding NP_009400.1 147596 R 4932 CDS NP_009401.1 6319318 851263 152259..153878 1 NC_001133.7 Subunit of the nuclear pore complex (NPC), functions to anchor Nup2p to the NPC in a process controlled by the nucleoplasmic concentration of Gsp1p-GTP; potential Cdc28p substrate; involved in telomere maintenance; Nup60p 153878 NUP60 851263 NUP60 Saccharomyces cerevisiae Nup60p NP_009401.1 152259 D 4932 CDS NP_009402.1 6319319 851264 complement(154067..154726) 1 NC_001133.7 Protein that forms a heterotrimeric complex with Erp2p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles; Erp1p 154726 ERP1 851264 ERP1 Saccharomyces cerevisiae Erp1p NP_009402.1 154067 R 4932 CDS NP_009403.1 6319320 851265 155007..156287 1 NC_001133.7 Swd1p; Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7 156287 SWD1 851265 SWD1 Saccharomyces cerevisiae Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7 NP_009403.1 155007 D 4932 CDS NP_009404.1 6319321 851266 complement(156756..158621) 1 NC_001133.7 Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; Rfa1p 158621 RFA1 851266 RFA1 Saccharomyces cerevisiae Rfa1p NP_009404.1 156756 R 4932 CDS NP_009405.1 6319322 851267 158967..159794 1 NC_001133.7 Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease; Sen34p 159794 SEN34 851267 SEN34 Saccharomyces cerevisiae Sen34p NP_009405.1 158967 D 4932 CDS NP_009406.1 6319323 851268 complement(160598..164188) 1 NC_001133.7 Yar009cp; Retrotransposon TYA Gag and TYB Pol genes; in YARCTY1-1 TYB is mutant and probably non-functional 164188 851268 YAR009C Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; in YARCTY1-1 TYB is mutant and probably non-functional NP_009406.1 160598 R 4932 CDS NP_009407.1 6319324 851269 complement(164545..165867) 1 NC_001133.7 Yar010cp; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; in YARCTY1-1 TYB is mutant and probably non-functional 165867 851269 YAR010C Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; in YARCTY1-1 TYB is mutant and probably non-functional NP_009407.1 164545 R 4932 CDS NP_009408.2 41629669 851271 complement(166743..168866) 1 NC_001133.7 Protein involved in bud-site selection, Bud14p-Glc7p complex functions as a cortical regulator of dynein; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; Bud14p 168866 BUD14 851271 BUD14 Saccharomyces cerevisiae Bud14p NP_009408.2 166743 R 4932 CDS NP_009409.1 6319326 851272 169370..170290 1 NC_001133.7 N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine; Ade1p 170290 ADE1 851272 ADE1 Saccharomyces cerevisiae Ade1p NP_009409.1 169370 D 4932 CDS NP_009410.1 6319327 851273 complement(170391..171698) 1 NC_001133.7 Nonessential protein kinase with unknown cellular role; Kin3p 171698 KIN3 851273 KIN3 Saccharomyces cerevisiae Kin3p NP_009410.1 170391 R 4932 CDS NP_009411.1 6319328 851274 complement(172209..175133) 1 NC_001133.7 Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; Cdc15p 175133 CDC15 851274 CDC15 Saccharomyces cerevisiae Cdc15p NP_009411.1 172209 R 4932 CDS NP_009412.1 6319329 851275 complement(176854..177021) 1 NC_001133.7 Pau7p; Part of 23-member seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme 177021 PAU7 851275 PAU7 Saccharomyces cerevisiae Part of 23-member seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme NP_009412.1 176854 R 4932 CDS NP_009413.1 6319330 851276 complement(179279..179818) 1 NC_001133.7 Yar023cp; Putative integral membrane protein, member of DUP240 gene family 179818 851276 YAR023C Saccharomyces cerevisiae Putative integral membrane protein, member of DUP240 gene family NP_009413.1 179279 R 4932 CDS NP_009414.1 6319331 851279 183764..184471 1 NC_001133.7 Uip3p; Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family 184471 UIP3 851279 UIP3 Saccharomyces cerevisiae Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family NP_009414.1 183764 D 4932 CDS NP_009415.1 6319332 851280 184886..185590 1 NC_001133.7 Yar028wp; Putative integral membrane protein, member of DUP240 gene family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS 185590 851280 YAR028W Saccharomyces cerevisiae Putative integral membrane protein, member of DUP240 gene family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS NP_009415.1 184886 D 4932 CDS NP_009416.1 6319333 851281 186315..186539 1 NC_001133.7 Yar029wp; Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 186539 851281 YAR029W Saccharomyces cerevisiae Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern NP_009416.1 186315 D 4932 CDS NP_009418.1 6319334 851282 186830..187726 1 NC_001133.7 Prm9p; Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family 187726 PRM9 851282 PRM9 Saccharomyces cerevisiae Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family NP_009418.1 186830 D 4932 CDS NP_009419.1 6319336 851284 188101..188805 1 NC_001133.7 Putative integral membrane protein, involved in vesicle formation; forms complex with Mst27p; member of DUP240 gene family; binds COPI and COPII vesicles; Mst28p 188805 MST28 851284 MST28 Saccharomyces cerevisiae Mst28p NP_009419.1 188101 D 4932 CDS NP_009420.1 6319337 851285 190187..192250 1 NC_001133.7 Yat1p; Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated 192250 YAT1 851285 YAT1 Saccharomyces cerevisiae Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated NP_009420.1 190187 D 4932 CDS NP_878042.1 33438758 1466430 complement(192331..192411) 1 NC_001133.7 Yar035c-ap; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 192411 1466430 YAR035C-A Saccharomyces cerevisiae Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching NP_878042.1 192331 R 4932 CDS NP_009421.3 85666110 851286 192613..196179 1 NC_001133.7 Swh1p; Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction 196179 SWH1 851286 SWH1 Saccharomyces cerevisiae Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction NP_009421.3 192613 D 4932 CDS NP_009424.1 6319341 851289 203394..208007 1 NC_001133.7 Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p; Flo1p 208007 FLO1 851289 FLO1 Saccharomyces cerevisiae Flo1p NP_009424.1 203394 D 4932 CDS NP_009429.1 6319346 851294 220189..220488 1 NC_001133.7 Yar064wp; Putative protein of unknown function 220488 851294 YAR064W Saccharomyces cerevisiae Putative protein of unknown function NP_009429.1 220189 D 4932 CDS NP_009430.1 6319347 851295 221040..221651 1 NC_001133.7 Yar066wp; Putative GPI protein 221651 851295 YAR066W Saccharomyces cerevisiae Putative GPI protein NP_009430.1 221040 D 4932 CDS NP_009431.1 6319348 851296 222397..222882 1 NC_001133.7 Yar068wp; Fungal-specific protein of unknown function; induced in respiratory-deficient cells 222882 851296 YAR068W Saccharomyces cerevisiae Fungal-specific protein of unknown function; induced in respiratory-deficient cells NP_009431.1 222397 D 4932 CDS NP_009434.1 6319351 851299 225451..226854 1 NC_001133.7 Pho11p; One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2 226854 PHO11 851299 PHO11 Saccharomyces cerevisiae One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2 NP_009434.1 225451 D 4932 CDS NP_009437.1 6319355 852159 complement(280..2658) 1 NC_001134.7 Ybl113cp; Helicase-like protein encoded within the telomeric Y' element 2658 852159 YBL113C Saccharomyces cerevisiae Helicase-like protein encoded within the telomeric Y' element NP_009437.1 280 R 4932 CDS NP_009438.1 6319356 852160 complement(2582..2899) 1 NC_001134.7 Ybl112cp; Putative protein of unknown function; YBL112C is contained within TEL02L 2899 852160 YBL112C Saccharomyces cerevisiae Putative protein of unknown function; YBL112C is contained within TEL02L NP_009438.1 2582 R 4932 CDS NP_009439.1 6319357 852161 complement(join(2907..4116,4216..5009)) 1 NC_001134.7 Ybl111cp; Helicase-like protein encoded within the telomeric Y' element 5009 852161 YBL111C Saccharomyces cerevisiae Helicase-like protein encoded within the telomeric Y' element NP_009439.1 2907 R 4932 CDS NP_076873.1 13129151 852163 complement(7605..7733) 1 NC_001134.7 hypothetical protein identified by homology. See FEBS Letters [2000] 487:31-36.; Pau9p 7733 PAU9 852163 PAU9 Saccharomyces cerevisiae Pau9p NP_076873.1 7605 R 4932 CDS NP_009443.1 6319361 852167 complement(9961..10551) 1 NC_001134.7 Ybl107cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YBL107C is not an essential gene 10551 852167 YBL107C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YBL107C is not an essential gene NP_009443.1 9961 R 4932 CDS NP_009444.1 6319362 852168 complement(10847..13879) 1 NC_001134.7 Sro77p; Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Sro7p and Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p 13879 SRO77 852168 SRO77 Saccharomyces cerevisiae Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Sro7p and Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p NP_009444.1 10847 R 4932 CDS NP_009445.1 6319363 852169 complement(14241..17696) 1 NC_001134.7 Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC); Pkc1p 17696 PKC1 852169 PKC1 Saccharomyces cerevisiae Pkc1p NP_009445.1 14241 R 4932 CDS NP_009446.2 41629671 852170 complement(18177..21293) 1 NC_001134.7 Ybl104cp; Putative protein of unknown function, promoter contains multiple GCN4 binding sites 21293 852170 YBL104C Saccharomyces cerevisiae Putative protein of unknown function, promoter contains multiple GCN4 binding sites NP_009446.2 18177 R 4932 CDS NP_009447.1 6319365 852171 complement(22075..23535) 1 NC_001134.7 Rtg3p; Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways 23535 RTG3 852171 RTG3 Saccharomyces cerevisiae Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways NP_009447.1 22075 R 4932 CDS NP_009448.1 6319366 852172 24098..24745 1 NC_001134.7 Sft2p; Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5 24745 SFT2 852172 SFT2 Saccharomyces cerevisiae Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5 NP_009448.1 24098 D 4932 CDS NP_009449.1 6319367 852173 complement(24946..28299) 1 NC_001134.7 Non-essential protein of unknown function; promoter contains several Gcn4p binding elements; Ecm21p 28299 ECM21 852173 ECM21 Saccharomyces cerevisiae Ecm21p NP_009449.1 24946 R 4932 CDS NP_878043.1 33438761 1466439 28427..28546 1 NC_001134.7 Ybl100w-cp; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 28546 1466439 YBL100W-C Saccharomyces cerevisiae Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching NP_878043.1 28427 D 4932 CDS NP_009450.1 6319369 852175 join(29932..31224,31226..35245) 1 NC_001134.7 Ybl100w-bp; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 35245 852175 YBL100W-B Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_009450.1 29932 D 4932 CDS NP_009451.1 6319368 852174 29932..31248 1 NC_001134.7 Ybl100w-ap; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 31248 852174 YBL100W-A Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_009451.1 29932 D 4932 CDS NP_009453.1 6319370 852177 37050..38687 1 NC_001134.7 Atp1p; Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated 38687 ATP1 852177 ATP1 Saccharomyces cerevisiae Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated NP_009453.1 37050 D 4932 CDS NP_009454.1 6319372 852179 39142..40524 1 NC_001134.7 Kynurenine 3-mono oxygenase, required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway; Bna4p 40524 BNA4 852179 BNA4 Saccharomyces cerevisiae Bna4p NP_009454.1 39142 D 4932 CDS NP_009455.2 41629672 852180 40828..43092 1 NC_001134.7 Essential protein required for chromosome condensation, likely to function as an intrinsic component of the condensation machinery, may influence multiple aspects of chromosome transmission and dynamics; Brn1p 43092 BRN1 852180 BRN1 Saccharomyces cerevisiae Brn1p NP_009455.2 40828 D 4932 CDS NP_009457.1 6319374 852181 43274..44086 1 NC_001134.7 Ybl095wp; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 44086 852181 YBL095W Saccharomyces cerevisiae Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_009457.1 43274 D 4932 CDS NP_009459.1 6319377 852184 complement(44253..44915) 1 NC_001134.7 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; Rox3p 44915 ROX3 852184 ROX3 Saccharomyces cerevisiae Rox3p NP_009459.1 44253 R 4932 CDS NP_009460.1 6319378 852185 45975..46367 1 NC_001134.7 Rpl32p; Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein; overexpression disrupts telomeric silencing 46367 RPL32 852185 RPL32 Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein; overexpression disrupts telomeric silencing NP_009460.1 45975 D 4932 CDS NP_009461.2 41629673 852186 complement(join(46562..47055,47144..47177)) 1 NC_001134.7 Scs22p; Protein involved in regulation of phospholipid metabolism; homolog of Scs2p; similar to D. melanogaster inturned protein 47177 SCS22 852186 SCS22 Saccharomyces cerevisiae Protein involved in regulation of phospholipid metabolism; homolog of Scs2p; similar to D. melanogaster inturned protein NP_009461.2 46562 R 4932 CDS NP_009462.1 6319380 852187 complement(47360..48625) 1 NC_001134.7 Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p; Map2p 48625 MAP2 852187 MAP2 Saccharomyces cerevisiae Map2p NP_009462.1 47360 R 4932 CDS NP_009463.1 6319381 852188 48822..49355 1 NC_001134.7 Mrp21p; Mitochondrial ribosomal protein of the large subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences 49355 MRP21 852188 MRP21 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences NP_009463.1 48822 D 4932 CDS NP_009464.2 37362614 852189 49571..50950 1 NC_001134.7 Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; Avt5p 50950 AVT5 852189 AVT5 Saccharomyces cerevisiae Avt5p NP_009464.2 49571 D 4932 CDS NP_009465.1 6319383 852190 complement(51016..59379) 1 NC_001134.7 Tel1p; Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; homolog of human ataxia telangiectasia (ATM) gene 59379 TEL1 852190 TEL1 Saccharomyces cerevisiae Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; homolog of human ataxia telangiectasia (ATM) gene NP_009465.1 51016 R 4932 CDS NP_009466.1 6319384 852191 complement(join(59818..60189,60694..60735)) 1 NC_001134.7 Rpl23ap; Protein component of the large (60S) ribosomal subunit, identical to Rpl23Bp and has similarity to E. coli L14 and rat L23 ribosomal proteins 60735 RPL23A 852191 RPL23A Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, identical to Rpl23Bp and has similarity to E. coli L14 and rat L23 ribosomal proteins NP_009466.1 59818 R 4932 CDS NP_009467.1 6319385 852192 complement(61199..62599) 1 NC_001134.7 Ybl086cp; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery 62599 852192 YBL086C Saccharomyces cerevisiae Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery NP_009467.1 61199 R 4932 CDS NP_009468.1 6319386 852193 63873..66815 1 NC_001134.7 Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; Boi1p 66815 BOI1 852193 BOI1 Saccharomyces cerevisiae Boi1p NP_009468.1 63873 D 4932 CDS NP_009469.1 6319387 852194 complement(67166..69442) 1 NC_001134.7 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; Cdc27p 69442 CDC27 852194 CDC27 Saccharomyces cerevisiae Cdc27p NP_009469.1 67166 R 4932 CDS NP_009471.1 6319389 852196 complement(69748..71124) 1 NC_001134.7 Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins; Alg3p 71124 ALG3 852196 ALG3 Saccharomyces cerevisiae Alg3p NP_009471.1 69748 R 4932 CDS NP_009472.1 6319390 852197 71863..72969 1 NC_001134.7 Ybl081wp; Non-essential protein of unknown function 72969 852197 YBL081W Saccharomyces cerevisiae Non-essential protein of unknown function NP_009472.1 71863 D 4932 CDS NP_009473.1 6319391 852198 complement(73067..74692) 1 NC_001134.7 Protein required for mitochondrial translation; mutation is functionally complemented by a Bacillus subtilis ortholog; Pet112p 74692 PET112 852198 PET112 Saccharomyces cerevisiae Pet112p NP_009473.1 73067 R 4932 CDS NP_009474.1 6319392 852199 75256..79764 1 NC_001134.7 Nup170p; Abundant subunit of the nuclear pore complex (NPC), required for proper localization of specific nucleoporins within the NPC, involved in nuclear envelope permeability and in chromosome segregation, has similarity to Nup157p 79764 NUP170 852199 NUP170 Saccharomyces cerevisiae Abundant subunit of the nuclear pore complex (NPC), required for proper localization of specific nucleoporins within the NPC, involved in nuclear envelope permeability and in chromosome segregation, has similarity to Nup157p NP_009474.1 75256 D 4932 CDS NP_009475.1 6319393 852200 complement(80375..80728) 1 NC_001134.7 Protein required for autophagy; modified by the serial action of Atg4p, Atg7p, and Atg3p, and conjugated at the C terminus with phosphatidylethanolamine, to become the form essential for generation of autophagosomes; Atg8p 80728 ATG8 852200 ATG8 Saccharomyces cerevisiae Atg8p NP_009475.1 80375 R 4932 CDS NP_009477.1 6319395 852202 complement(81041..84259) 1 NC_001134.7 Ils1p; Cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin A 84259 ILS1 852202 ILS1 Saccharomyces cerevisiae Cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin A NP_009477.1 81041 R 4932 CDS NP_009478.1 6319396 852203 complement(84497..86446) 1 NC_001134.7 Ssa3p; ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm 86446 SSA3 852203 SSA3 Saccharomyces cerevisiae ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm NP_009478.1 84497 R 4932 CDS NP_009479.1 6319398 852205 complement(86720..87787) 1 NC_001134.7 Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron; Aar2p 87787 AAR2 852205 AAR2 Saccharomyces cerevisiae Aar2p NP_009479.1 86720 R 4932 CDS NP_009481.1 6319399 852206 complement(88521..89123) 1 NC_001134.7 Rps8ap; Protein component of the small (40S) ribosomal subunit; identical to Rps8Bp and has similarity to rat S8 ribosomal protein 89123 RPS8A 852206 RPS8A Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit; identical to Rps8Bp and has similarity to rat S8 ribosomal protein NP_009481.1 88521 R 4932 CDS NP_878044.1 33438762 1466440 complement(89456..89554) 1 NC_001134.7 Ybl071c-bp; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 89554 1466440 YBL071C-B Saccharomyces cerevisiae Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching NP_878044.1 89456 R 4932 CDS NP_660100.1 21648335 852207 89976..90224 1 NC_001134.7 Zn-ribbon electron carrier protein, required with Dph1p, Dph2p, Jjj3p, and Dph5p for synthesis of diphthamide, a modified histidine residue on Eft1p or Eft2p; required, with Elongator complex, for modification of wobble nucleosides in tRNA; Kti11p 90224 KTI11 852207 KTI11 Saccharomyces cerevisiae Kti11p NP_660100.1 89976 D 4932 CDS NP_009484.2 14270687 852209 90739..92028 1 NC_001134.7 Peripheral membrane protein that interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane, possibly by influencing its incorporation into lipid rafts; Ast1p 92028 AST1 852209 AST1 Saccharomyces cerevisiae Ast1p NP_009484.2 90739 D 4932 CDS NP_009485.2 37362615 852211 92412..93395 1 NC_001134.7 Prs4p; 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involved in nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes 93395 PRS4 852211 PRS4 Saccharomyces cerevisiae 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involved in nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes NP_009485.2 92412 D 4932 CDS NP_009486.2 50593116 852212 complement(93641..95884) 1 NC_001134.7 Ubp13p; Putative ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease that cleaves ubiquitin-protein fusions 95884 UBP13 852212 UBP13 Saccharomyces cerevisiae Putative ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease that cleaves ubiquitin-protein fusions NP_009486.2 93641 R 4932 CDS NP_009487.2 50593117 852214 complement(96671..100117) 1 NC_001134.7 Sef1p; Putative transcription factor, has homolog in Kluyveromyces lactis 100117 SEF1 852214 SEF1 Saccharomyces cerevisiae Putative transcription factor, has homolog in Kluyveromyces lactis NP_009487.2 96671 R 4932 CDS NP_009489.1 6319407 852215 complement(100373..101158) 1 NC_001134.7 Prx1p; Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress; phosphorylated 101158 PRX1 852215 PRX1 Saccharomyces cerevisiae Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress; phosphorylated NP_009489.1 100373 R 4932 CDS NP_009490.1 6319408 852216 101888..105223 1 NC_001134.7 Kip1p; Kinesin-related motor protein required for mitotic spindle assembly and chromosome segregation; functionally redundant with Cin8p 105223 KIP1 852216 KIP1 Saccharomyces cerevisiae Kinesin-related motor protein required for mitotic spindle assembly and chromosome segregation; functionally redundant with Cin8p NP_009490.1 101888 D 4932 CDS NP_009492.1 6319410 852218 complement(105318..107408) 1 NC_001134.7 Skt5p; Activator of Chs3p (chitin synthase III), recruits Chs3p to the bud neck via interaction with Bni4p; has similarity to Shc1p, which activates Chs3p during sporulation 107408 SKT5 852218 SKT5 Saccharomyces cerevisiae Activator of Chs3p (chitin synthase III), recruits Chs3p to the bud neck via interaction with Bni4p; has similarity to Shc1p, which activates Chs3p during sporulation NP_009492.1 105318 R 4932 CDS NP_009493.1 6319411 852219 107934..109997 1 NC_001134.7 Yel1p; Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required for localization of Arf3p to the bud neck and tip 109997 YEL1 852219 YEL1 Saccharomyces cerevisiae Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required for localization of Arf3p to the bud neck and tip NP_009493.1 107934 D 4932 CDS NP_031358.1 6681845 852220 complement(join(110127..110422,110508..110541)) 1 NC_001134.7 Ybl059c-ap; Putative protein of unknown function; contains twin Cx9C motifs that can form coiled coil-helix-coiled-coil helix fold; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus 110541 852220 YBL059C-A Saccharomyces cerevisiae Putative protein of unknown function; contains twin Cx9C motifs that can form coiled coil-helix-coiled-coil helix fold; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus NP_031358.1 110127 R 4932 CDS NP_009494.1 6319412 852221 join(110596..110881,110951..111246) 1 NC_001134.7 Ybl059wp; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 111246 852221 YBL059W Saccharomyces cerevisiae Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_009494.1 110596 D 4932 CDS NP_009495.1 6319413 852222 111439..112710 1 NC_001134.7 UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate; Shp1p 112710 SHP1 852222 SHP1 Saccharomyces cerevisiae Shp1p NP_009495.1 111439 D 4932 CDS NP_009496.1 6319414 852223 complement(112803..113447) 1 NC_001134.7 Pth2p; One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth 113447 PTH2 852223 PTH2 Saccharomyces cerevisiae One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth NP_009496.1 112803 R 4932 CDS NP_009497.1 6319415 852224 113765..115171 1 NC_001134.7 Type 2C protein phosphatase; dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA checkpoint inactivation; Ptc3p 115171 PTC3 852224 PTC3 Saccharomyces cerevisiae Ptc3p NP_009497.1 113765 D 4932 CDS NP_009498.1 6319416 852225 complement(115576..116832) 1 NC_001134.7 Ybl055cp; 3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases 116832 852225 YBL055C Saccharomyces cerevisiae 3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases NP_009498.1 115576 R 4932 CDS NP_009499.1 6319417 852226 117592..119169 1 NC_001134.7 Ybl054wp; Protein of unknown function involved in rRNA and ribosome biosynthesis 119169 852226 YBL054W Saccharomyces cerevisiae Protein of unknown function involved in rRNA and ribosome biosynthesis NP_009499.1 117592 D 4932 CDS NP_009501.1 6319419 852228 complement(119382..121877) 1 NC_001134.7 Sas3p; Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; sas3 gcn5 double mutation confers lethality 121877 SAS3 852228 SAS3 Saccharomyces cerevisiae Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; sas3 gcn5 double mutation confers lethality NP_009501.1 119382 R 4932 CDS NP_009502.1 6319420 852229 complement(122756..124762) 1 NC_001134.7 Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage; Pin4p 124762 PIN4 852229 PIN4 Saccharomyces cerevisiae Pin4p NP_009502.1 122756 R 4932 CDS NP_009503.1 6319421 852230 join(125128..125157,125274..126122) 1 NC_001134.7 Sec17p; Peripheral membrane protein required for vesicular transport between ER and Golgi and for the 'priming' step in homotypic vacuole fusion, part of the cis-SNARE complex; has similarity to alpha-SNAP 126122 SEC17 852230 SEC17 Saccharomyces cerevisiae Peripheral membrane protein required for vesicular transport between ER and Golgi and for the 'priming' step in homotypic vacuole fusion, part of the cis-SNARE complex; has similarity to alpha-SNAP NP_009503.1 125128 D 4932 CDS NP_009504.1 6319422 852231 126831..127247 1 NC_001134.7 Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phase; Moh1p 127247 MOH1 852231 MOH1 Saccharomyces cerevisiae Moh1p NP_009504.1 126831 D 4932 CDS NP_009506.1 6319424 852233 complement(127898..132043) 1 NC_001134.7 Key endocytic protein involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins; Ede1p 132043 EDE1 852233 EDE1 Saccharomyces cerevisiae Ede1p NP_009506.1 127898 R 4932 CDS NP_009507.1 6319425 852234 132427..133752 1 NC_001134.7 Putative regulatory subunit of an evolutionarily conserved protein phosphatase complex containing the catalytic subunit Pph3p and a third subunit Psy2p; required for cisplatin resistance; GFP-fusion protein localizes to the nucleus; Psy4p 133752 PSY4 852234 PSY4 Saccharomyces cerevisiae Psy4p NP_009507.1 132427 D 4932 CDS NP_009508.1 6319426 852235 complement(134146..135519) 1 NC_001134.7 Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain; Cor1p 135519 COR1 852235 COR1 Saccharomyces cerevisiae Cor1p NP_009508.1 134146 R 4932 CDS NP_009509.1 6319427 852236 136001..136369 1 NC_001134.7 Ybl044wp; Putative protein of unknown function; YBL044W is not an essential protein 136369 852236 YBL044W Saccharomyces cerevisiae Putative protein of unknown function; YBL044W is not an essential protein NP_009509.1 136001 D 4932 CDS NP_009510.1 6319428 852237 136691..137464 1 NC_001134.7 Non-essential protein of unknown function; Ecm13p 137464 ECM13 852237 ECM13 Saccharomyces cerevisiae Ecm13p NP_009510.1 136691 D 4932 CDS NP_009511.1 6319429 852238 complement(138344..140263) 1 NC_001134.7 High affinity uridine permease, localized to the plasma membrane; not involved in uracil transport; Fui1p 140263 FUI1 852238 FUI1 Saccharomyces cerevisiae Fui1p NP_009511.1 138344 R 4932 CDS NP_009512.1 6319430 852239 141250..141975 1 NC_001134.7 Pre7p; 20S proteasome beta-type subunit 141975 PRE7 852239 PRE7 Saccharomyces cerevisiae 20S proteasome beta-type subunit NP_009512.1 141250 D 4932 CDS NP_009513.1 6319431 852240 complement(join(142115..142752,142850..142871)) 1 NC_001134.7 HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins; Erd2p 142871 ERD2 852240 ERD2 Saccharomyces cerevisiae Erd2p NP_009513.1 142115 R 4932 CDS NP_878045.1 33438763 1466441 143396..143575 1 NC_001134.7 Ybl039w-bp; Putative protein of unknown function 143575 1466441 YBL039W-B Saccharomyces cerevisiae Putative protein of unknown function NP_878045.1 143396 D 4932 CDS NP_009514.1 6319432 852241 complement(143992..145731) 1 NC_001134.7 Ura7p; Major CTP synthase isozyme (see also URA8), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis 145731 URA7 852241 URA7 Saccharomyces cerevisiae Major CTP synthase isozyme (see also URA8), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis NP_009514.1 143992 R 4932 CDS NP_009515.1 6319433 852242 146190..146888 1 NC_001134.7 Mrpl16p; Mitochondrial ribosomal protein of the large subunit 146888 MRPL16 852242 MRPL16 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit NP_009515.1 146190 D 4932 CDS NP_009516.1 6319434 852243 147212..150289 1 NC_001134.7 Apl3p; Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport 150289 APL3 852243 APL3 Saccharomyces cerevisiae Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport NP_009516.1 147212 D 4932 CDS NP_009517.1 6319435 852244 complement(150450..151223) 1 NC_001134.7 Ybl036cp; Single-domain racemase, possibly non-specific due to the lack of the second domain, which presumably determines specificity; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS 151223 852244 YBL036C Saccharomyces cerevisiae Single-domain racemase, possibly non-specific due to the lack of the second domain, which presumably determines specificity; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS NP_009517.1 150450 R 4932 CDS NP_009518.1 6319436 852245 complement(151496..153613) 1 NC_001134.7 Pol12p; B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation 153613 POL12 852245 POL12 Saccharomyces cerevisiae B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation NP_009518.1 151496 R 4932 CDS NP_009519.1 6319437 852246 complement(153851..158392) 1 NC_001134.7 Stu1p; Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles 158392 STU1 852246 STU1 Saccharomyces cerevisiae Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles NP_009519.1 153851 R 4932 CDS NP_009520.1 6319438 852247 complement(158659..159696) 1 NC_001134.7 Rib1p; GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway 159696 RIB1 852247 RIB1 Saccharomyces cerevisiae GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway NP_009520.1 158659 R 4932 CDS NP_009521.1 6319439 852248 160187..161332 1 NC_001134.7 RNA binding protein with similarity to hnRNP-K that localizes to the cytoplasm and to subtelomeric DNA; required for the proper localization of ASH1 mRNA; involved in the regulation of telomere position effect and telomere length; Hek2p 161332 HEK2 852248 HEK2 Saccharomyces cerevisiae Hek2p NP_009521.1 160187 D 4932 CDS NP_009522.1 6319440 852249 161702..162718 1 NC_001134.7 She1p; Cytoskeletal protein of unknown function; overexpression causes growth arrest 162718 SHE1 852249 SHE1 Saccharomyces cerevisiae Cytoskeletal protein of unknown function; overexpression causes growth arrest NP_009522.1 161702 D 4932 CDS NP_009523.1 6319441 852250 complement(163044..164000) 1 NC_001134.7 Pet9p; Major ADP/ATP carrier of the mitochondrial inner membrane, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; required for viability in many common lab strains carrying a mutation in the polymorphic SAL1 gene 164000 PET9 852250 PET9 Saccharomyces cerevisiae Major ADP/ATP carrier of the mitochondrial inner membrane, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; required for viability in many common lab strains carrying a mutation in the polymorphic SAL1 gene NP_009523.1 163044 R 4932 CDS NP_076874.1 13129152 852251 complement(164491..164775) 1 NC_001134.7 Ybl029c-ap; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica 164775 852251 YBL029C-A Saccharomyces cerevisiae Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica NP_076874.1 164491 R 4932 CDS NP_009524.1 6319442 852252 166137..167267 1 NC_001134.7 Ybl029wp; Non-essential protein of unknown function 167267 852252 YBL029W Saccharomyces cerevisiae Non-essential protein of unknown function NP_009524.1 166137 D 4932 CDS NP_009525.1 6319443 852253 complement(167521..167841) 1 NC_001134.7 Ybl028cp; Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis 167841 852253 YBL028C Saccharomyces cerevisiae Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis NP_009525.1 167521 R 4932 CDS NP_009526.1 6319444 852254 join(168426..168427,168812..169379) 1 NC_001134.7 Rpl19bp; Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Ap and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal 169379 RPL19B 852254 RPL19B Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Ap and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal NP_009526.1 168426 D 4932 CDS NP_009527.1 6319445 852255 join(170626..170679,170808..171041) 1 NC_001134.7 Lsm2p; Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA 171041 LSM2 852255 LSM2 Saccharomyces cerevisiae Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA NP_009527.1 170626 D 4932 CDS NP_009528.1 6319446 852256 171484..171921 1 NC_001134.7 Rrn10p; Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I 171921 RRN10 852256 RRN10 Saccharomyces cerevisiae Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I NP_009528.1 171484 D 4932 CDS NP_009529.1 6319447 852257 172537..174591 1 NC_001134.7 S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; similar to Nop2p and human proliferation associated nucleolar protein p120; Ncl1p 174591 NCL1 852257 NCL1 Saccharomyces cerevisiae Ncl1p NP_009529.1 172537 D 4932 CDS NP_009530.1 6319448 852258 complement(174923..177529) 1 NC_001134.7 Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; Mcm2p 177529 MCM2 852258 MCM2 Saccharomyces cerevisiae Mcm2p NP_009530.1 174923 R 4932 CDS NP_009531.1 6319449 852259 complement(177877..181278) 1 NC_001134.7 Pim1p; ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria 181278 PIM1 852259 PIM1 Saccharomyces cerevisiae ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria NP_009531.1 177877 R 4932 CDS NP_009532.1 6319450 852260 complement(181663..182097) 1 NC_001134.7 Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding; Hap3p 182097 HAP3 852260 HAP3 Saccharomyces cerevisiae Hap3p NP_009532.1 181663 R 4932 CDS NP_009533.1 6319451 852261 182404..184128 1 NC_001134.7 Rft1p; Flippase, essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane; mutation is suppressed by expression human p53 protein 184128 RFT1 852261 RFT1 Saccharomyces cerevisiae Flippase, essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane; mutation is suppressed by expression human p53 protein NP_009533.1 182404 D 4932 CDS NP_009534.1 6319452 852262 184356..185918 1 NC_001134.7 Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII; Apn2p 185918 APN2 852262 APN2 Saccharomyces cerevisiae Apn2p NP_009534.1 184356 D 4932 CDS NP_009535.1 6319453 852263 complement(join(186001..186355,186431..186477)) 1 NC_001134.7 Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; Pop8p 186477 POP8 852263 POP8 Saccharomyces cerevisiae Pop8p NP_009535.1 186001 R 4932 CDS NP_009536.1 6319454 852264 complement(186847..191586) 1 NC_001134.7 Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments; Pep1p 191586 PEP1 852264 PEP1 Saccharomyces cerevisiae Pep1p NP_009536.1 186847 R 4932 CDS NP_009537.1 6319455 852265 192454..193515 1 NC_001134.7 Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its degradation; Fus3p 193515 FUS3 852265 FUS3 Saccharomyces cerevisiae Fus3p NP_009537.1 192454 D 4932 CDS NP_009538.1 6319456 852266 194125..195705 1 NC_001134.7 Ach1p; Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth 195705 ACH1 852266 ACH1 Saccharomyces cerevisiae Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth NP_009538.1 194125 D 4932 CDS NP_009539.1 6319457 852269 complement(199067..201751) 1 NC_001134.7 Rrn6p; Protein involved in the transcription of 35S rRNA genes by RNA polymerase I; component of the core factor (CF) complex also composed of Rrn11p, Rrn7p and TATA-binding protein 201751 RRN6 852269 RRN6 Saccharomyces cerevisiae Protein involved in the transcription of 35S rRNA genes by RNA polymerase I; component of the core factor (CF) complex also composed of Rrn11p, Rrn7p and TATA-binding protein NP_009539.1 199067 R 4932 CDS NP_009540.2 41629674 852270 202059..203264 1 NC_001134.7 Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate; Fmt1p 203264 FMT1 852270 FMT1 Saccharomyces cerevisiae Fmt1p NP_009540.2 202059 D 4932 CDS NP_009542.1 6319459 852271 203541..205820 1 NC_001134.7 Sct1p; Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed 205820 SCT1 852271 SCT1 Saccharomyces cerevisiae Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed NP_009542.1 203541 D 4932 CDS NP_009543.1 6319461 852273 complement(206110..206952) 1 NC_001134.7 Ybl010cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles 206952 852273 YBL010C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles NP_009543.1 206110 R 4932 CDS NP_009544.1 6319462 852274 207197..209227 1 NC_001134.7 Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; similar to Alk1p and to mammalian haspins; Alk2p 209227 ALK2 852274 ALK2 Saccharomyces cerevisiae Alk2p NP_009544.1 207197 D 4932 CDS NP_878046.1 33438764 1466442 209412..209651 1 NC_001134.7 Ybl008w-ap; Putative protein of unknown function; identified by fungal homology and RT-PCR 209651 1466442 YBL008W-A Saccharomyces cerevisiae Putative protein of unknown function; identified by fungal homology and RT-PCR NP_878046.1 209412 D 4932 CDS NP_009545.1 6319463 852275 209656..212178 1 NC_001134.7 Non-essential transcriptional corepressor involved in the cell cycle-regulated transcription of histone H2A, H2B, H3 and H4 genes; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores; Hir1p 212178 HIR1 852275 HIR1 Saccharomyces cerevisiae Hir1p NP_009545.1 209656 D 4932 CDS NP_009546.1 6319464 852276 complement(212635..216369) 1 NC_001134.7 Sla1p; Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains 216369 SLA1 852276 SLA1 Saccharomyces cerevisiae Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains NP_009546.1 212635 R 4932 CDS NP_009547.2 41629675 852277 complement(216590..217132) 1 NC_001134.7 Ldb7p; Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions 217132 LDB7 852277 LDB7 Saccharomyces cerevisiae Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions NP_009547.2 216590 R 4932 CDS NP_009548.1 6319466 852278 217473..220403 1 NC_001134.7 Transcriptional activator of the pleiotropic drug resistance network, regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); Pdr3p 220403 PDR3 852278 PDR3 Saccharomyces cerevisiae Pdr3p NP_009548.1 217473 D 4932 CDS NP_009549.1 6319468 852280 join(221333..222637,222639..226601) 1 NC_001134.7 Ybl005w-bp; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 226601 852280 YBL005W-B Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_009549.1 221333 D 4932 CDS NP_009550.1 6319467 852279 221333..222655 1 NC_001134.7 Ybl005w-ap; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 222655 852279 YBL005W-A Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_009550.1 221333 D 4932 CDS NP_009551.2 14270688 852282 227639..235120 1 NC_001134.7 Utp20p; Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA 235120 UTP20 852282 UTP20 Saccharomyces cerevisiae Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA NP_009551.2 227639 D 4932 CDS NP_009552.1 6319470 852283 complement(235397..235795) 1 NC_001134.7 One of two nearly identical (see also HTA1) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p; Hta2p 235795 HTA2 852283 HTA2 Saccharomyces cerevisiae Hta2p NP_009552.1 235397 R 4932 CDS NP_009553.1 6319471 852284 236495..236890 1 NC_001134.7 One of two nearly identical (see HTB1) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation; Htb2p 236890 HTB2 852284 HTB2 Saccharomyces cerevisiae Htb2p NP_009553.1 236495 D 4932 CDS NP_009554.1 6319472 852285 complement(237155..237469) 1 NC_001134.7 Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis; Ecm15p 237469 ECM15 852285 ECM15 Saccharomyces cerevisiae Ecm15p NP_009554.1 237155 R 4932 CDS NP_009555.1 6319473 852286 complement(238943..241285) 1 NC_001134.7 Putative neutral trehalase, required for thermotolerance and may mediate resistance to other cellular stresses; Nth2p 241285 NTH2 852286 NTH2 Saccharomyces cerevisiae Nth2p NP_009555.1 238943 R 4932 CDS NP_009556.1 6319474 852287 complement(241710..242570) 1 NC_001134.7 Rer2p; Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting 242570 RER2 852287 RER2 Saccharomyces cerevisiae Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting NP_009556.1 241710 R 4932 CDS NP_009557.1 6319475 852288 242811..244232 1 NC_001134.7 Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis; Coq1p 244232 COQ1 852288 COQ1 Saccharomyces cerevisiae Coq1p NP_009557.1 242811 D 4932 CDS NP_009558.1 6319476 852289 complement(244368..245669) 1 NC_001134.7 Gpi18p; Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria 245669 GPI18 852289 GPI18 Saccharomyces cerevisiae Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria NP_009558.1 244368 R 4932 CDS NP_009559.1 6319477 852290 245908..246549 1 NC_001134.7 Rcr1p; Protein of the ER membrane involved in cell wall chitin deposition; may function in the endosomal-vacuolar trafficking pathway, helping determine whether plasma membrane proteins are degraded or routed to the plasma membrane 246549 RCR1 852290 RCR1 Saccharomyces cerevisiae Protein of the ER membrane involved in cell wall chitin deposition; may function in the endosomal-vacuolar trafficking pathway, helping determine whether plasma membrane proteins are degraded or routed to the plasma membrane NP_009559.1 245908 D 4932 CDS NP_009560.1 6319478 852291 247012..248505 1 NC_001134.7 Uga2p; Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm 248505 UGA2 852291 UGA2 Saccharomyces cerevisiae Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm NP_009560.1 247012 D 4932 CDS NP_009561.1 6319479 852292 complement(248807..251017) 1 NC_001134.7 Dsf2p; Deletion suppressor of mpt5 mutation 251017 DSF2 852292 DSF2 Saccharomyces cerevisiae Deletion suppressor of mpt5 mutation NP_009561.1 248807 R 4932 CDS NP_009562.1 6319480 852293 complement(252564..254210) 1 NC_001134.7 Plasma membrane multidrug transporter of the major facilitator superfamily, involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; Flr1p 254210 FLR1 852293 FLR1 Saccharomyces cerevisiae Flr1p NP_009562.1 252564 R 4932 CDS NP_009563.1 6319481 852294 complement(255371..255682) 1 NC_001134.7 One of two identical histone H4 proteins (see also HHF2); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity; Hhf1p 255682 HHF1 852294 HHF1 Saccharomyces cerevisiae Hhf1p NP_009563.1 255371 R 4932 CDS NP_009564.1 6319482 852295 256329..256739 1 NC_001134.7 One of two identical histone H3 proteins (see also HHT2); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation; Hht1p 256739 HHT1 852295 HHT1 Saccharomyces cerevisiae Hht1p NP_009564.1 256329 D 4932 CDS NP_009565.1 6319483 852296 complement(257110..257973) 1 NC_001134.7 Ipp1p; Cytoplasmic inorganic pyrophosphatase (PPase), catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase 257973 IPP1 852296 IPP1 Saccharomyces cerevisiae Cytoplasmic inorganic pyrophosphatase (PPase), catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase NP_009565.1 257110 R 4932 CDS NP_009567.1 6319486 852299 join(259867..261171,261173..265138) 1 NC_001134.7 Ybr012w-bp; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 265138 852299 YBR012W-B Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_009567.1 259867 D 4932 CDS NP_009568.1 6319485 852298 259867..261189 1 NC_001134.7 Ybr012w-ap; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 261189 852298 YBR012W-A Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_009568.1 259867 D 4932 CDS NP_009569.1 6319487 852300 complement(265490..265879) 1 NC_001134.7 Ybr013cp; Putative protein of unknown function, haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein 265879 852300 YBR013C Saccharomyces cerevisiae Putative protein of unknown function, haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein NP_009569.1 265490 R 4932 CDS NP_009570.1 6319488 852302 complement(266725..267336) 1 NC_001134.7 Monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; membrane localized; forms homodimers; does not bind metal ions; Grx7p 267336 GRX7 852302 GRX7 Saccharomyces cerevisiae Grx7p NP_009570.1 266725 R 4932 CDS NP_009571.1 6319489 852303 complement(267710..269503) 1 NC_001134.7 Mnn2p; Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment 269503 MNN2 852303 MNN2 Saccharomyces cerevisiae Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment NP_009571.1 267710 R 4932 CDS NP_009572.1 6319490 852304 270247..270633 1 NC_001134.7 Ybr016wp; Plasma membrane protein of unknown function; has similarity to hydrophilins, which are hydrophilic, glycine-rich proteins involved in the adaptive response to hyperosmotic conditions 270633 852304 YBR016W Saccharomyces cerevisiae Plasma membrane protein of unknown function; has similarity to hydrophilins, which are hydrophilic, glycine-rich proteins involved in the adaptive response to hyperosmotic conditions NP_009572.1 270247 D 4932 CDS NP_009573.1 6319491 852305 complement(270947..273703) 1 NC_001134.7 Transportin, cytosolic karyopherin beta 2 involved in delivery of heterogeneous nuclear ribonucleoproteins to the nucleoplasm, binds rg-nuclear localization signals on Nab2p and Hrp1p, plays a role in cell-cycle progression; Kap104p 273703 KAP104 852305 KAP104 Saccharomyces cerevisiae Kap104p NP_009573.1 270947 R 4932 CDS NP_009574.1 6319492 852306 complement(274427..275527) 1 NC_001134.7 Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism; Gal7p 275527 GAL7 852306 GAL7 Saccharomyces cerevisiae Gal7p NP_009574.1 274427 R 4932 CDS NP_009575.1 6319493 852307 complement(276253..278352) 1 NC_001134.7 UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers; Gal10p 278352 GAL10 852307 GAL10 Saccharomyces cerevisiae Gal10p NP_009575.1 276253 R 4932 CDS NP_009576.1 6319494 852308 279021..280607 1 NC_001134.7 Galactokinase, phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; Gal1p 280607 GAL1 852308 GAL1 Saccharomyces cerevisiae Gal1p NP_009576.1 279021 D 4932 CDS NP_009577.1 6319495 852309 281443..283344 1 NC_001134.7 Uracil permease, localized to the plasma membrane; expression is tightly regulated by uracil levels and environmental cues; Fur4p 283344 FUR4 852309 FUR4 Saccharomyces cerevisiae Fur4p NP_009577.1 281443 D 4932 CDS NP_009578.1 6319496 852310 283738..284271 1 NC_001134.7 Poa1p; Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing 284271 POA1 852310 POA1 Saccharomyces cerevisiae Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing NP_009578.1 283738 D 4932 CDS NP_009579.1 6319497 852311 complement(284428..287925) 1 NC_001134.7 Chs3p; Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan 287925 CHS3 852311 CHS3 Saccharomyces cerevisiae Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan NP_009579.1 284428 R 4932 CDS NP_009580.1 6319498 852312 289445..290350 1 NC_001134.7 Sco2p; Protein anchored to the mitochondrial inner membrane, similar to Sco1p and may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p 290350 SCO2 852312 SCO2 Saccharomyces cerevisiae Protein anchored to the mitochondrial inner membrane, similar to Sco1p and may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p NP_009580.1 289445 D 4932 CDS NP_009581.1 6319499 852313 complement(290681..291865) 1 NC_001134.7 P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; protein levels are induced by hydrogen peroxide; Ola1p 291865 OLA1 852313 OLA1 Saccharomyces cerevisiae Ola1p NP_009581.1 290681 R 4932 CDS NP_009582.1 6319500 852314 complement(292877..294019) 1 NC_001134.7 Etr1p; 2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis 294019 ETR1 852314 ETR1 Saccharomyces cerevisiae 2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis NP_009582.1 292877 R 4932 CDS NP_009584.1 6319502 852316 complement(294425..296002) 1 NC_001134.7 Ybr028cp; Putative protein kinase, possible substrate of cAMP-dependent protein kinase (PKA) 296002 852316 YBR028C Saccharomyces cerevisiae Putative protein kinase, possible substrate of cAMP-dependent protein kinase (PKA) NP_009584.1 294425 R 4932 CDS NP_009585.1 6319503 852317 complement(296369..297742) 1 NC_001134.7 Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids; Cds1p 297742 CDS1 852317 CDS1 Saccharomyces cerevisiae Cds1p NP_009585.1 296369 R 4932 CDS NP_009586.1 6319504 852318 298292..299950 1 NC_001134.7 Ybr030wp; Putative protein of unknown function; predicted protein contains a SET domain (S-adenosyl-L-methionine-binding fold) 299950 852318 YBR030W Saccharomyces cerevisiae Putative protein of unknown function; predicted protein contains a SET domain (S-adenosyl-L-methionine-binding fold) NP_009586.1 298292 D 4932 CDS NP_009587.1 6319505 852319 300166..301254 1 NC_001134.7 Rpl4ap; N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Bp and has similarity to E. coli L4 and rat L4 ribosomal proteins 301254 RPL4A 852319 RPL4A Saccharomyces cerevisiae N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Bp and has similarity to E. coli L4 and rat L4 ribosomal proteins NP_009587.1 300166 D 4932 CDS NP_009589.1 6319507 852321 301944..304703 1 NC_001134.7 Putative zinc cluster protein; YBR033W is not an essential gene; Eds1p 304703 EDS1 852321 EDS1 Saccharomyces cerevisiae Eds1p NP_009589.1 301944 D 4932 CDS NP_009590.1 6319508 852322 complement(304930..305976) 1 NC_001134.7 Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, thus facilitating nuclear export of these proteins; required for viability of npl3 mutants; Hmt1p 305976 HMT1 852322 HMT1 Saccharomyces cerevisiae Hmt1p NP_009590.1 304930 R 4932 CDS NP_009591.1 6319509 852323 complement(306269..306955) 1 NC_001134.7 Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism; Pdx3p 306955 PDX3 852323 PDX3 Saccharomyces cerevisiae Pdx3p NP_009591.1 306269 R 4932 CDS NP_009592.1 6319510 852324 complement(309081..310313) 1 NC_001134.7 Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; Csg2p 310313 CSG2 852324 CSG2 Saccharomyces cerevisiae Csg2p NP_009592.1 309081 R 4932 CDS NP_009593.1 6319511 852325 complement(310564..311451) 1 NC_001134.7 Sco1p; Copper-binding protein of the mitochondrial inner membrane, required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; has similarity to thioredoxins 311451 SCO1 852325 SCO1 Saccharomyces cerevisiae Copper-binding protein of the mitochondrial inner membrane, required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; has similarity to thioredoxins NP_009593.1 310564 R 4932 CDS NP_009594.1 6319512 852326 311897..314788 1 NC_001134.7 Chs2p; Chitin synthase II, requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for the synthesis of chitin in the primary septum during cytokinesis 314788 CHS2 852326 CHS2 Saccharomyces cerevisiae Chitin synthase II, requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for the synthesis of chitin in the primary septum during cytokinesis NP_009594.1 311897 D 4932 CDS NP_009595.1 6319513 852327 315575..316510 1 NC_001134.7 Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; Atp3p 316510 ATP3 852327 ATP3 Saccharomyces cerevisiae Atp3p NP_009595.1 315575 D 4932 CDS NP_009596.1 6319514 852328 316968..317864 1 NC_001134.7 Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating; Fig1p 317864 FIG1 852328 FIG1 Saccharomyces cerevisiae Fig1p NP_009596.1 316968 D 4932 CDS NP_009597.2 41629676 852329 318266..320275 1 NC_001134.7 Fatty acid transporter and very long-chain fatty acyl-CoA synthetase, may form a complex with Faa1p or Faa4p that imports and activates exogenous fatty acids; Fat1p 320275 FAT1 852329 FAT1 Saccharomyces cerevisiae Fat1p NP_009597.2 318266 D 4932 CDS NP_009598.1 6319516 852330 complement(320416..321609) 1 NC_001134.7 Protein of unknown function, affects chromosome stability when overexpressed; Cst26p 321609 CST26 852330 CST26 Saccharomyces cerevisiae Cst26p NP_009598.1 320416 R 4932 CDS NP_009599.1 6319517 852331 complement(321876..323945) 1 NC_001134.7 Qdr3p; Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, barban, cisplatin, and bleomycin 323945 QDR3 852331 QDR3 Saccharomyces cerevisiae Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, barban, cisplatin, and bleomycin NP_009599.1 321876 R 4932 CDS NP_009600.1 6319518 852332 complement(324337..326058) 1 NC_001134.7 Tcm62p; Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone 326058 TCM62 852332 TCM62 Saccharomyces cerevisiae Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone NP_009600.1 324337 R 4932 CDS NP_009601.1 6319519 852334 complement(328369..330090) 1 NC_001134.7 Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p; Gip1p 330090 GIP1 852334 GIP1 Saccharomyces cerevisiae Gip1p NP_009601.1 328369 R 4932 CDS NP_009602.1 6319520 852335 complement(330505..331509) 1 NC_001134.7 Zta1p; Zeta-crystallin homolog, found in the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin, which has quinone oxidoreductase activity 331509 ZTA1 852335 ZTA1 Saccharomyces cerevisiae Zeta-crystallin homolog, found in the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin, which has quinone oxidoreductase activity NP_009602.1 330505 R 4932 CDS NP_009603.1 6319521 852336 331831..332358 1 NC_001134.7 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Fmp23p 332358 FMP23 852336 FMP23 Saccharomyces cerevisiae Fmp23p NP_009603.1 331831 D 4932 CDS NP_009604.1 6319522 852337 join(332829..332873,333385..333810) 1 NC_001134.7 Rps11bp; Protein component of the small (40S) ribosomal subunit; identical to Rps11Ap and has similarity to E. coli S17 and rat S11 ribosomal proteins 333810 RPS11B 852337 RPS11B Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit; identical to Rps11Ap and has similarity to E. coli S17 and rat S11 ribosomal proteins NP_009604.1 332829 D 4932 CDS NP_009605.1 6319523 852338 complement(334384..336816) 1 NC_001134.7 Reb1p; RNA polymerase I enhancer binding protein; DNA binding protein which binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription 336816 REB1 852338 REB1 Saccharomyces cerevisiae RNA polymerase I enhancer binding protein; DNA binding protein which binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription NP_009605.1 334384 R 4932 CDS NP_009606.1 6319525 852340 complement(337181..338197) 1 NC_001134.7 Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease; Reg2p 338197 REG2 852340 REG2 Saccharomyces cerevisiae Reg2p NP_009606.1 337181 R 4932 CDS NP_009608.1 6319526 852341 complement(338718..339350) 1 NC_001134.7 Rfs1p; Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 339350 RFS1 852341 RFS1 Saccharomyces cerevisiae Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern NP_009608.1 338718 R 4932 CDS NP_009609.1 6319527 852342 complement(339673..340749) 1 NC_001134.7 Ybr053cp; Putative protein of unknown function; induced by cell wall perturbation 340749 852342 YBR053C Saccharomyces cerevisiae Putative protein of unknown function; induced by cell wall perturbation NP_009609.1 339673 R 4932 CDS NP_009610.1 6319528 852343 343099..344133 1 NC_001134.7 Yro2p; Putative protein of unknown function; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p 344133 YRO2 852343 YRO2 Saccharomyces cerevisiae Putative protein of unknown function; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p NP_009610.1 343099 D 4932 CDS NP_009611.1 6319529 852344 complement(344600..347299) 1 NC_001134.7 Splicing factor, component of the U4/U6-U5 snRNP complex; Prp6p 347299 PRP6 852344 PRP6 Saccharomyces cerevisiae Prp6p NP_009611.1 344600 R 4932 CDS NP_009612.1 6319530 852346 347877..349382 1 NC_001134.7 Ybr056wp; Putative cytoplasmic protein of unknown function 349382 852346 YBR056W Saccharomyces cerevisiae Putative cytoplasmic protein of unknown function NP_009612.1 347877 D 4932 CDS NP_009613.1 6319531 852348 complement(352191..353291) 1 NC_001134.7 Mum2p; Cytoplasmic protein essential for meiotic DNA replication and sporulation; interacts with Orc2p, which is a component of the origin recognition complex 353291 MUM2 852348 MUM2 Saccharomyces cerevisiae Cytoplasmic protein essential for meiotic DNA replication and sporulation; interacts with Orc2p, which is a component of the origin recognition complex NP_009613.1 352191 R 4932 CDS NP_009614.2 37362616 852349 complement(353670..356015) 1 NC_001134.7 Ubp14p; Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T 356015 UBP14 852349 UBP14 Saccharomyces cerevisiae Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T NP_009614.2 353670 R 4932 CDS NP_116327.1 14270689 852350 complement(356322..356564) 1 NC_001134.7 Tsc3p; Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis 356564 TSC3 852350 TSC3 Saccharomyces cerevisiae Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis NP_116327.1 356322 R 4932 CDS NP_009615.1 6319533 852351 complement(356859..360185) 1 NC_001134.7 Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization; Akl1p 360185 AKL1 852351 AKL1 Saccharomyces cerevisiae Akl1p NP_009615.1 356859 R 4932 CDS NP_009616.1 6319534 852352 complement(360650..362512) 1 NC_001134.7 Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p; Orc2p 362512 ORC2 852352 ORC2 Saccharomyces cerevisiae Orc2p NP_009616.1 360650 R 4932 CDS NP_009617.1 6319535 852353 complement(364785..365717) 1 NC_001134.7 Trm7p; 2'-O-ribose methyltransferase, methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop 365717 TRM7 852353 TRM7 Saccharomyces cerevisiae 2'-O-ribose methyltransferase, methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop NP_009617.1 364785 R 4932 CDS NP_009618.2 50593118 852354 complement(join(365974..366500,366583..366598)) 1 NC_001134.7 Ybr062cp 366598 852354 YBR062C Saccharomyces cerevisiae Ybr062cp NP_009618.2 365974 R 4932 CDS NP_009619.1 6319538 852356 complement(366968..368182) 1 NC_001134.7 Ybr063cp; Putative protein of unknown function; YBR063C is not an essential gene 368182 852356 YBR063C Saccharomyces cerevisiae Putative protein of unknown function; YBR063C is not an essential gene NP_009619.1 366968 R 4932 CDS NP_009621.1 6319539 852357 complement(368582..369676) 1 NC_001134.7 Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p; Ecm2p 369676 ECM2 852357 ECM2 Saccharomyces cerevisiae Ecm2p NP_009621.1 368582 R 4932 CDS NP_009622.1 6319540 852358 complement(370035..370697) 1 NC_001134.7 Transcriptional repressor that mediates glucose repression and negatively regulates filamentous growth; has similarity to Nrg1p; Nrg2p 370697 NRG2 852358 NRG2 Saccharomyces cerevisiae Nrg2p NP_009622.1 370035 R 4932 CDS NP_009623.1 6319541 852359 complement(372100..372732) 1 NC_001134.7 Tip1p; Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins 372732 TIP1 852359 TIP1 Saccharomyces cerevisiae Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins NP_009623.1 372100 R 4932 CDS NP_009624.1 6319542 852360 complement(373858..375687) 1 NC_001134.7 High-affinity leucine permease, functions as a branched-chain amino acid permease involved in the uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; Bap2p 375687 BAP2 852360 BAP2 Saccharomyces cerevisiae Bap2p NP_009624.1 373858 R 4932 CDS NP_009625.1 6319543 852361 complement(376571..378430) 1 NC_001134.7 Tat1p; Amino acid transport protein for valine, leucine, isoleucine, and tyrosine, low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance 378430 TAT1 852361 TAT1 Saccharomyces cerevisiae Amino acid transport protein for valine, leucine, isoleucine, and tyrosine, low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance NP_009625.1 376571 R 4932 CDS NP_009626.1 6319544 852362 complement(379218..379931) 1 NC_001134.7 Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases; Alg14p 379931 ALG14 852362 ALG14 Saccharomyces cerevisiae Alg14p NP_009626.1 379218 R 4932 CDS NP_009627.1 6319545 852363 380408..381043 1 NC_001134.7 Ybr071wp; Putative protein of unknown function; (GFP)-fusion and epitope-tagged proteins localize to the cytoplasm; mRNA expression may be regulated by the cell cycle and/or cell wall stress 381043 852363 YBR071W Saccharomyces cerevisiae Putative protein of unknown function; (GFP)-fusion and epitope-tagged proteins localize to the cytoplasm; mRNA expression may be regulated by the cell cycle and/or cell wall stress NP_009627.1 380408 D 4932 CDS NP_009628.1 6319546 852364 382027..382671 1 NC_001134.7 Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells; Hsp26p 382671 HSP26 852364 HSP26 Saccharomyces cerevisiae Hsp26p NP_009628.1 382027 D 4932 CDS NP_878048.1 33438766 1466444 complement(382855..383016) 1 NC_001134.7 Ybr072c-ap; Putative protein of unknown function; identified by fungal homology and RT-PCR 383016 1466444 YBR072C-A Saccharomyces cerevisiae Putative protein of unknown function; identified by fungal homology and RT-PCR NP_878048.1 382855 R 4932 CDS NP_009629.2 37362617 852365 383209..385983 1 NC_001134.7 Rdh54p; DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis; proposed to be involved in crossover interference 385983 RDH54 852365 RDH54 Saccharomyces cerevisiae DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis; proposed to be involved in crossover interference NP_009629.2 383209 D 4932 CDS NP_009630.2 37362618 852366 386281..389211 1 NC_001134.7 Ybr074wp; Putative metalloprotease 389211 852366 YBR074W Saccharomyces cerevisiae Putative metalloprotease NP_009630.2 386281 D 4932 CDS NP_009632.1 6319550 852368 390369..391388 1 NC_001134.7 Non-essential protein of unknown function; Ecm8p 391388 ECM8 852368 ECM8 Saccharomyces cerevisiae Ecm8p NP_009632.1 390369 D 4932 CDS NP_009633.1 6319551 852369 complement(391799..392287) 1 NC_001134.7 Slm4p; Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4 392287 SLM4 852369 SLM4 Saccharomyces cerevisiae Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4 NP_009633.1 391799 R 4932 CDS NP_009634.1 6319552 852370 join(393118..393175,393506..394854) 1 NC_001134.7 GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p; Ecm33p 394854 ECM33 852370 ECM33 Saccharomyces cerevisiae Ecm33p NP_009634.1 393118 D 4932 CDS NP_009635.1 6319553 852371 complement(395377..398271) 1 NC_001134.7 Subunit of the core complex of translation initiation factor 3(eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes; Rpg1p 398271 RPG1 852371 RPG1 Saccharomyces cerevisiae Rpg1p NP_009635.1 395377 R 4932 CDS NP_009636.1 6319554 852372 complement(398608..400884) 1 NC_001134.7 Sec18p; ATPase required for the release of Sec17p during the 'priming' step in homotypic vacuole fusion and for ER to Golgi transport; homolog of the mammalian NSF 400884 SEC18 852372 SEC18 Saccharomyces cerevisiae ATPase required for the release of Sec17p during the 'priming' step in homotypic vacuole fusion and for ER to Golgi transport; homolog of the mammalian NSF NP_009636.1 398608 R 4932 CDS NP_009637.1 6319555 852373 complement(401247..405245) 1 NC_001134.7 Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex; Spt7p 405245 SPT7 852373 SPT7 Saccharomyces cerevisiae Spt7p NP_009637.1 401247 R 4932 CDS NP_009638.1 6319556 852376 complement(join(406622..407021,407117..407163)) 1 NC_001134.7 Ubiquitin-conjugating enzyme (E2), mediates degradation of short-lived and abnormal proteins; interacts with E3-CaM in ubiquitinating calmodulin; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; Ubc4p 407163 UBC4 852376 UBC4 Saccharomyces cerevisiae Ubc4p NP_009638.1 406622 R 4932 CDS NP_009639.1 6319557 852377 409163..410623 1 NC_001134.7 Transcription factor required for full Ty1 epxression, Ty1-mediated gene activation, and haploid invasive and diploid pseudohyphal growth; TEA/ATTS DNA-binding domain family member; Tec1p 410623 TEC1 852377 TEC1 Saccharomyces cerevisiae Tec1p NP_009639.1 409163 D 4932 CDS NP_009640.1 6319558 852378 411048..413975 1 NC_001134.7 Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase; Mis1p 413975 MIS1 852378 MIS1 Saccharomyces cerevisiae Mis1p NP_009640.1 411048 D 4932 CDS NP_009641.1 6319559 852379 complement(join(414180..414747,415254..415255)) 1 NC_001134.7 Rpl19ap; Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Bp and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal 415255 RPL19A 852379 RPL19A Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Bp and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal NP_009641.1 414180 R 4932 CDS NP_009642.1 6319560 852380 415977..416900 1 NC_001134.7 Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Pet9p and Aac1p; has roles in maintenance of viability and in respiration; Aac3p 416900 AAC3 852380 AAC3 Saccharomyces cerevisiae Aac3p NP_009642.1 415977 D 4932 CDS NP_061491.1 9755326 852381 complement(418901..419158) 1 NC_001134.7 Ybr085c-ap; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus 419158 852381 YBR085C-A Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus NP_061491.1 418901 R 4932 CDS NP_009643.2 27808701 852382 complement(420195..423035) 1 NC_001134.7 Plasma membrane protein that may be involved in osmotolerance, localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process; Ist2p 423035 IST2 852382 IST2 Saccharomyces cerevisiae Ist2p NP_009643.2 420195 R 4932 CDS NP_009644.1 6319562 852383 423759..424823 1 NC_001134.7 Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; Rfc5p 424823 RFC5 852383 RFC5 Saccharomyces cerevisiae Rfc5p NP_009644.1 423759 D 4932 CDS NP_009645.1 6319564 852385 complement(424984..425760) 1 NC_001134.7 Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair; Pol30p 425760 POL30 852385 POL30 Saccharomyces cerevisiae Pol30p NP_009645.1 424984 R 4932 CDS NP_009647.1 6319565 852386 complement(426184..426483) 1 NC_001134.7 Nhp6bp; High-mobility group non-histone chromatin protein, functionally redundant with Nhp6Ap; homologous to mammalian high mobility group proteins 1 and 2; acts to recruit transcription factor Rcs1p to certain promoters 426483 NHP6B 852386 NHP6B Saccharomyces cerevisiae High-mobility group non-histone chromatin protein, functionally redundant with Nhp6Ap; homologous to mammalian high mobility group proteins 1 and 2; acts to recruit transcription factor Rcs1p to certain promoters NP_009647.1 426184 R 4932 CDS NP_009648.1 6319566 852387 complement(join(426327..426510,426868..427052)) 1 NC_001134.7 Ybr090cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus 427052 852387 YBR090C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus NP_009648.1 426327 R 4932 CDS NP_009649.1 6319567 852388 complement(427149..427478) 1 NC_001134.7 Mrs5p; Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins 427478 MRS5 852388 MRS5 Saccharomyces cerevisiae Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins NP_009649.1 427149 R 4932 CDS NP_009650.1 6319568 852389 complement(427692..429095) 1 NC_001134.7 Pho3p; Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin 429095 PHO3 852389 PHO3 Saccharomyces cerevisiae Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin NP_009650.1 427692 R 4932 CDS NP_009651.1 6319569 852390 complement(429542..430945) 1 NC_001134.7 Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2; Pho5p 430945 PHO5 852390 PHO5 Saccharomyces cerevisiae Pho5p NP_009651.1 429542 R 4932 CDS NP_009652.1 6319570 852391 432030..434291 1 NC_001134.7 Putative tubulin tyrosine ligase associated with P-bodies; Pby1p 434291 PBY1 852391 PBY1 Saccharomyces cerevisiae Pby1p NP_009652.1 432030 D 4932 CDS NP_009653.2 37362619 852392 complement(434400..435692) 1 NC_001134.7 Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth; Rxt2p 435692 RXT2 852392 RXT2 Saccharomyces cerevisiae Rxt2p NP_009653.2 434400 R 4932 CDS NP_009654.1 6319572 852393 436015..436707 1 NC_001134.7 Ybr096wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER 436707 852393 YBR096W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER NP_009654.1 436015 D 4932 CDS NP_009655.1 6319573 852394 436945..441309 1 NC_001134.7 Vps15p; Myristoylated serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p 441309 VPS15 852394 VPS15 Saccharomyces cerevisiae Myristoylated serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p NP_009655.1 436945 D 4932 CDS NP_009656.2 27808702 852395 441509..443584 1 NC_001134.7 Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination and DNA repair; Mms4p 443584 MMS4 852395 MMS4 Saccharomyces cerevisiae Mms4p NP_009656.2 441509 D 4932 CDS NP_009659.1 6319577 852397 complement(443815..444687) 1 NC_001134.7 Hsp70 (Ssa1p) nucleotide exchange factor, cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; Fes1p 444687 FES1 852397 FES1 Saccharomyces cerevisiae Fes1p NP_009659.1 443815 R 4932 CDS NP_009660.1 6319578 852398 complement(445056..447317) 1 NC_001134.7 Exo84p; Essential protein with dual roles in spliceosome assembly and exocytosis; the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p) mediates polarized targeting of secretory vesicles to active sites of exocytosis 447317 EXO84 852398 EXO84 Saccharomyces cerevisiae Essential protein with dual roles in spliceosome assembly and exocytosis; the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p) mediates polarized targeting of secretory vesicles to active sites of exocytosis NP_009660.1 445056 R 4932 CDS NP_009661.1 6319579 852399 447703..449310 1 NC_001134.7 WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus; Sif2p 449310 SIF2 852399 SIF2 Saccharomyces cerevisiae Sif2p NP_009661.1 447703 D 4932 CDS NP_009662.1 6319580 852401 449661..450650 1 NC_001134.7 Ymc2p; Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc1p 450650 YMC2 852401 YMC2 Saccharomyces cerevisiae Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc1p NP_009662.1 449661 D 4932 CDS NP_009663.1 6319581 852402 complement(450875..451963) 1 NC_001134.7 Vid24p; Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; involved in proteasome-dependent catabolite degradation of FBPase 451963 VID24 852402 VID24 Saccharomyces cerevisiae Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; involved in proteasome-dependent catabolite degradation of FBPase NP_009663.1 450875 R 4932 CDS NP_009664.1 6319582 852403 452652..453218 1 NC_001134.7 Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations; Pho88p 453218 PHO88 852403 PHO88 Saccharomyces cerevisiae Pho88p NP_009664.1 452652 D 4932 CDS NP_009665.1 6319583 852404 complement(453787..454524) 1 NC_001134.7 Protein with a role in kinetochore function, localizes to the outer kinetochore in a Ctf19p-dependent manner, interacts with Chl4p and Ctf19p; Iml3p 454524 IML3 852404 IML3 Saccharomyces cerevisiae Iml3p NP_009665.1 453787 R 4932 CDS NP_009666.2 50234882 852405 454816..457659 1 NC_001134.7 Protein interacting with Rsv167p; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media; Aim3p 457659 AIM3 852405 AIM3 Saccharomyces cerevisiae Aim3p NP_009666.2 454816 D 4932 CDS NP_009667.1 6319585 852406 complement(457913..458356) 1 NC_001134.7 Cmd1p; Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin 458356 CMD1 852406 CMD1 Saccharomyces cerevisiae Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin NP_009667.1 457913 R 4932 CDS NP_009668.1 6319586 852407 458866..460215 1 NC_001134.7 Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog; Alg1p 460215 ALG1 852407 ALG1 Saccharomyces cerevisiae Alg1p NP_009668.1 458866 D 4932 CDS NP_009669.1 6319587 852408 complement(461172..461867) 1 NC_001134.7 Ysa1p; Nudix hydrolase family member with ADP-ribose pyrophosphatase activity 461867 YSA1 852408 YSA1 Saccharomyces cerevisiae Nudix hydrolase family member with ADP-ribose pyrophosphatase activity NP_009669.1 461172 R 4932 CDS NP_878049.2 41629677 1466445 join(462133..462203,462284..462423,462494..462573) 1 NC_001134.7 Sus1p; Protein involved in mRNA export coupled transcription activation; component of the SAGA histone acetylase complex 462573 SUS1 1466445 SUS1 Saccharomyces cerevisiae Protein involved in mRNA export coupled transcription activation; component of the SAGA histone acetylase complex NP_878049.2 462133 D 4932 CDS NP_009670.1 6319589 852410 complement(462864..465764) 1 NC_001134.7 General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters; Cyc8p 465764 CYC8 852410 CYC8 Saccharomyces cerevisiae Cyc8p NP_009670.1 462864 R 4932 CDS NP_009672.1 6319590 852411 467242..469614 1 NC_001134.7 Rad16p; Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex 469614 RAD16 852411 RAD16 Saccharomyces cerevisiae Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex NP_009672.1 467242 D 4932 CDS NP_009673.1 6319591 852412 complement(469742..473920) 1 NC_001134.7 Lys2p; Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p 473920 LYS2 852412 LYS2 Saccharomyces cerevisiae Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p NP_009673.1 469742 R 4932 CDS NP_009675.1 6319593 852414 complement(474386..476431) 1 NC_001134.7 Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; Tkl2p 476431 TKL2 852414 TKL2 Saccharomyces cerevisiae Tkl2p NP_009675.1 474386 R 4932 CDS NP_009676.1 6319594 852415 477665..479041 1 NC_001134.7 Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; Tef2p 479041 TEF2 852415 TEF2 Saccharomyces cerevisiae Tef2p NP_009676.1 477665 D 4932 CDS NP_009677.1 6319595 852416 join(479332..479339,479429..480317) 1 NC_001134.7 U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing; Mud1p 480317 MUD1 852416 MUD1 Saccharomyces cerevisiae Mud1p NP_009677.1 479332 D 4932 CDS NP_009678.1 6319596 852417 complement(480429..480917) 1 NC_001134.7 Mitochondrial translational activator of the COB mRNA; phosphorylated; Cbp6p 480917 CBP6 852417 CBP6 Saccharomyces cerevisiae Cbp6p NP_009678.1 480429 R 4932 CDS NP_009679.1 6319597 852418 complement(481358..483361) 1 NC_001134.7 Grs1p; Cytoplasmic and mitochondrial glycyl-tRNA synthase that ligates glycine to the cognate anticodon bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation 483361 GRS1 852418 GRS1 Saccharomyces cerevisiae Cytoplasmic and mitochondrial glycyl-tRNA synthase that ligates glycine to the cognate anticodon bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation NP_009679.1 481358 R 4932 CDS NP_009680.2 37362620 852419 complement(483964..484497) 1 NC_001134.7 Mrpl36p; Mitochondrial ribosomal protein of the large subunit; overproduction suppresses mutations in the COX2 leader peptide-encoding region 484497 MRPL36 852419 MRPL36 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit; overproduction suppresses mutations in the COX2 leader peptide-encoding region NP_009680.2 483964 R 4932 CDS NP_009681.1 6319600 852421 complement(484736..486685) 1 NC_001134.7 Tfc1p; One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TFIIIC-63 486685 TFC1 852421 TFC1 Saccharomyces cerevisiae One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TFIIIC-63 NP_009681.1 484736 R 4932 CDS NP_009683.1 6319601 852422 complement(487193..488374) 1 NC_001134.7 Ptc4p; Cytoplasmic type 2C protein phosphatase; identified as a high-copy number suppressor of the synthetic lethality of a cnb1 mpk1 double deletion; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity 488374 PTC4 852422 PTC4 Saccharomyces cerevisiae Cytoplasmic type 2C protein phosphatase; identified as a high-copy number suppressor of the synthetic lethality of a cnb1 mpk1 double deletion; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity NP_009683.1 487193 R 4932 CDS NP_009684.1 6319602 852423 complement(488899..490386) 1 NC_001134.7 Tps1p; Synthase subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway 490386 TPS1 852423 TPS1 Saccharomyces cerevisiae Synthase subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway NP_009684.1 488899 R 4932 CDS NP_009685.1 6319603 852424 complement(491263..492816) 1 NC_001134.7 Vma2p; Subunit B of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; contains nucleotide binding sites; also detected in the cytoplasm 492816 VMA2 852424 VMA2 Saccharomyces cerevisiae Subunit B of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; contains nucleotide binding sites; also detected in the cytoplasm NP_009685.1 491263 R 4932 CDS NP_009686.1 6319604 852425 complement(493075..494109) 1 NC_001134.7 Subunit of an autophagy-specific phosphatidylinositol 3-kinase complex (with Vps34p, Vps15p, and Vps30p) required for organization of a pre-autophagosomal structure; ATG14 transcription is activated by Gln3p during nitrogen starvation; Atg14p 494109 ATG14 852425 ATG14 Saccharomyces cerevisiae Atg14p NP_009686.1 493075 R 4932 CDS NP_009687.1 6319605 852426 complement(494347..495333) 1 NC_001134.7 Protein of unknown function, overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Opy1p 495333 OPY1 852426 OPY1 Saccharomyces cerevisiae Opy1p NP_009687.1 494347 R 4932 CDS NP_009688.1 6319606 852427 complement(495586..496863) 1 NC_001134.7 She3p; Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance 496863 SHE3 852427 SHE3 Saccharomyces cerevisiae Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance NP_009688.1 495586 R 4932 CDS NP_009689.1 6319607 852428 497157..499271 1 NC_001134.7 Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway; Ccz1p 499271 CCZ1 852428 CCZ1 Saccharomyces cerevisiae Ccz1p NP_009689.1 497157 D 4932 CDS NP_009690.1 6319608 852429 complement(499646..501436) 1 NC_001134.7 High affinity polyamine permease, preferentially uses spermidine over putrescine; expression is down-regulated by osmotic stress; plasma membrane carnitine transporter, also functions as a low-affinity amino acid permease; Agp2p 501436 AGP2 852429 AGP2 Saccharomyces cerevisiae Agp2p NP_009690.1 499646 R 4932 CDS NP_009691.1 6319610 852431 complement(501798..504281) 1 NC_001134.7 Protein arginine N-methyltransferase that exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; Hsl7p 504281 HSL7 852431 HSL7 Saccharomyces cerevisiae Hsl7p NP_009691.1 501798 R 4932 CDS NP_009693.1 6319611 852432 504848..505300 1 NC_001134.7 Cyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters; Cks1p 505300 CKS1 852432 CKS1 Saccharomyces cerevisiae Cks1p NP_009693.1 504848 D 4932 CDS NP_009694.1 6319612 852433 505662..512768 1 NC_001134.7 Mec1p; Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; monitors and participates in meiotic recombination 512768 MEC1 852433 MEC1 Saccharomyces cerevisiae Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; monitors and participates in meiotic recombination NP_009694.1 505662 D 4932 CDS NP_009695.1 6319613 852434 513038..513577 1 NC_001134.7 Ybr137wp; Protein of unknown function; localized to the cytoplasm; binds to Replication Protein A (RPA); YBR137W is not an essential gene 513577 852434 YBR137W Saccharomyces cerevisiae Protein of unknown function; localized to the cytoplasm; binds to Replication Protein A (RPA); YBR137W is not an essential gene NP_009695.1 513038 D 4932 CDS NP_009696.1 6319614 852435 complement(513756..515330) 1 NC_001134.7 Ybr138cp; Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene 515330 852435 YBR138C Saccharomyces cerevisiae Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene NP_009696.1 513756 R 4932 CDS NP_009697.1 6319615 852436 515658..517184 1 NC_001134.7 Ybr139wp; Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner 517184 852436 YBR139W Saccharomyces cerevisiae Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner NP_009697.1 515658 D 4932 CDS NP_009698.1 6319616 852437 complement(517344..526622) 1 NC_001134.7 Ira1p; GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase 526622 IRA1 852437 IRA1 Saccharomyces cerevisiae GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase NP_009698.1 517344 R 4932 CDS NP_009699.1 6319617 852438 complement(527019..528032) 1 NC_001134.7 Ybr141cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YBR141C is not an essential gene 528032 852438 YBR141C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YBR141C is not an essential gene NP_009699.1 527019 R 4932 CDS NP_009700.1 6319618 852439 528311..530632 1 NC_001134.7 Mak5p; Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits 530632 MAK5 852439 MAK5 Saccharomyces cerevisiae Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits NP_009700.1 528311 D 4932 CDS NP_009701.1 6319619 852440 complement(530863..532176) 1 NC_001134.7 Sup45p; Polypeptide release factor involved in translation termination; mutant form acts as a recessive omnipotent suppressor 532176 SUP45 852440 SUP45 Saccharomyces cerevisiae Polypeptide release factor involved in translation termination; mutant form acts as a recessive omnipotent suppressor NP_009701.1 530863 R 4932 CDS NP_009703.1 6319621 852442 533756..534811 1 NC_001134.7 Alcohol dehydrogenase isoenzyme V; involved in ethanol production; Adh5p 534811 ADH5 852442 ADH5 Saccharomyces cerevisiae Adh5p NP_009703.1 533756 D 4932 CDS NP_009704.1 6319622 852443 535254..536090 1 NC_001134.7 Mrps9p; Mitochondrial ribosomal protein of the small subunit 536090 MRPS9 852443 MRPS9 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the small subunit NP_009704.1 535254 D 4932 CDS NP_009705.1 6319623 852444 536569..537459 1 NC_001134.7 Ybr147wp; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays fluconazole resistance 537459 852444 YBR147W Saccharomyces cerevisiae Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays fluconazole resistance NP_009705.1 536569 D 4932 CDS NP_009706.1 6319624 852445 537870..539699 1 NC_001134.7 Ysw1p; Protein expressed specifically in spores 539699 YSW1 852445 YSW1 Saccharomyces cerevisiae Protein expressed specifically in spores NP_009706.1 537870 D 4932 CDS NP_009707.1 6319625 852446 539981..541015 1 NC_001134.7 NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product; Ara1p 541015 ARA1 852446 ARA1 Saccharomyces cerevisiae Ara1p NP_009707.1 539981 D 4932 CDS NP_009708.1 6319626 852447 complement(541203..544487) 1 NC_001134.7 Tbs1p; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 544487 TBS1 852447 TBS1 Saccharomyces cerevisiae Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_009708.1 541203 R 4932 CDS NP_009709.1 6319627 852448 545022..545972 1 NC_001134.7 Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus; Apd1p 545972 APD1 852448 APD1 Saccharomyces cerevisiae Apd1p NP_009709.1 545022 D 4932 CDS NP_009710.1 6319628 852449 546370..547245 1 NC_001134.7 mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p; Spp381p 547245 SPP381 852449 SPP381 Saccharomyces cerevisiae Spp381p NP_009710.1 546370 D 4932 CDS NP_009711.1 6319629 852450 547454..548188 1 NC_001134.7 Rib7p; Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway 548188 RIB7 852450 RIB7 Saccharomyces cerevisiae Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway NP_009711.1 547454 D 4932 CDS NP_009712.1 6319630 852451 complement(548356..549003) 1 NC_001134.7 Rpb5p; RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation 549003 RPB5 852451 RPB5 Saccharomyces cerevisiae RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation NP_009712.1 548356 R 4932 CDS NP_009713.1 6319631 852452 549765..550922 1 NC_001134.7 TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion; Cns1p 550922 CNS1 852452 CNS1 Saccharomyces cerevisiae Cns1p NP_009713.1 549765 D 4932 CDS NP_009714.1 6319632 852453 complement(551098..553194) 1 NC_001134.7 Subunit of the Ipl1p-Sli15p-Bir1p complex that regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly; regulates the activity and localization of the Ipl1p aurora kinase; Sli15p 553194 SLI15 852453 SLI15 Saccharomyces cerevisiae Sli15p NP_009714.1 551098 R 4932 CDS NP_009715.2 41629678 852454 complement(553537..554304) 1 NC_001134.7 Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization; Ics2p 554304 ICS2 852454 ICS2 Saccharomyces cerevisiae Ics2p NP_009715.2 553537 R 4932 CDS NP_009716.1 6319634 852455 556543..558192 1 NC_001134.7 Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN); Amn1p 558192 AMN1 852455 AMN1 Saccharomyces cerevisiae Amn1p NP_009716.1 556543 D 4932 CDS NP_009717.1 6319635 852456 558679..559722 1 NC_001134.7 Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides; Ifa38p 559722 IFA38 852456 IFA38 Saccharomyces cerevisiae Ifa38p NP_009717.1 558679 D 4932 CDS NP_009718.1 6319636 852457 560072..560968 1 NC_001134.7 Cdc28p; Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates 560968 CDC28 852457 CDC28 Saccharomyces cerevisiae Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates NP_009718.1 560072 D 4932 CDS NP_009719.1 6319637 852458 561629..562759 1 NC_001134.7 Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p; Csh1p 562759 CSH1 852458 CSH1 Saccharomyces cerevisiae Csh1p NP_009719.1 561629 D 4932 CDS NP_009720.1 6319638 852459 complement(563198..564565) 1 NC_001134.7 Tos1p; Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C 564565 TOS1 852459 TOS1 Saccharomyces cerevisiae Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C NP_009720.1 563198 R 4932 CDS NP_009721.1 6319639 852460 565226..565423 1 NC_001134.7 Ysy6p; Protein whose expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion 565423 YSY6 852460 YSY6 Saccharomyces cerevisiae Protein whose expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion NP_009721.1 565226 D 4932 CDS NP_009722.1 6319640 852461 565718..567475 1 NC_001134.7 Protein of unknown function, shows similarity to RNA-processing protein Pta1p; Dem1p 567475 DEM1 852461 DEM1 Saccharomyces cerevisiae Dem1p NP_009722.1 565718 D 4932 CDS NP_009723.1 6319641 852462 complement(567870..568421) 1 NC_001134.7 Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor; Arl1p 568421 ARL1 852462 ARL1 Saccharomyces cerevisiae Arl1p NP_009723.1 567870 R 4932 CDS NP_009724.1 6319642 852463 568847..569680 1 NC_001134.7 Ubs1p; Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity 569680 UBS1 852463 UBS1 Saccharomyces cerevisiae Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity NP_009724.1 568847 D 4932 CDS NP_009725.1 6319643 852464 complement(569837..571195) 1 NC_001134.7 Tyr1p; Prephenate dehydrogenase involved in tyrosine biosynthesis, expression is dependent on phenylalanine levels 571195 TYR1 852464 TYR1 Saccharomyces cerevisiae Prephenate dehydrogenase involved in tyrosine biosynthesis, expression is dependent on phenylalanine levels NP_009725.1 569837 R 4932 CDS NP_009726.1 6319644 852465 complement(571463..571885) 1 NC_001134.7 Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; Pop7p 571885 POP7 852465 POP7 Saccharomyces cerevisiae Pop7p NP_009726.1 571463 R 4932 CDS NP_009727.1 6319645 852466 572366..573607 1 NC_001134.7 Pex32p; Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p 573607 PEX32 852466 PEX32 Saccharomyces cerevisiae Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p NP_009727.1 572366 D 4932 CDS NP_009728.1 6319646 852467 complement(573910..575991) 1 NC_001134.7 Sse2p; Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; highly homologous to the heat shock protein Sse1p 575991 SSE2 852467 SSE2 Saccharomyces cerevisiae Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; highly homologous to the heat shock protein Sse1p NP_009728.1 573910 R 4932 CDS NP_009729.1 6319647 852468 complement(576339..578081) 1 NC_001134.7 Npl4p; Endoplasmic reticulum and nuclear membrane protein, forms a complex with Cdc48p and Ufd1p that recognizes ubiquitinated proteins in the endoplasmic reticulum and delivers them to the proteasome for degradation 578081 NPL4 852468 NPL4 Saccharomyces cerevisiae Endoplasmic reticulum and nuclear membrane protein, forms a complex with Cdc48p and Ufd1p that recognizes ubiquitinated proteins in the endoplasmic reticulum and delivers them to the proteasome for degradation NP_009729.1 576339 R 4932 CDS NP_009730.1 6319648 852469 578359..578979 1 NC_001134.7 Sec66p; Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER 578979 SEC66 852469 SEC66 Saccharomyces cerevisiae Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER NP_009730.1 578359 D 4932 CDS NP_009731.2 37362621 852470 complement(579145..581367) 1 NC_001134.7 Smy2p; Protein of unknown function that interacts with Myo2p; has similarity to S. pombe Mpd2 581367 SMY2 852470 SMY2 Saccharomyces cerevisiae Protein of unknown function that interacts with Myo2p; has similarity to S. pombe Mpd2 NP_009731.2 579145 R 4932 CDS NP_009732.1 6319650 852471 complement(581721..582167) 1 NC_001134.7 Ump1p; Short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly 582167 UMP1 852471 UMP1 Saccharomyces cerevisiae Short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly NP_009732.1 581721 R 4932 CDS NP_009734.1 6319651 852472 582403..583350 1 NC_001134.7 Swd3p; Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5 583350 SWD3 852472 SWD3 Saccharomyces cerevisiae Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5 NP_009734.1 582403 D 4932 CDS NP_009735.1 6319653 852474 583715..584653 1 NC_001134.7 Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate; Ecm31p 584653 ECM31 852474 ECM31 Saccharomyces cerevisiae Ecm31p NP_009735.1 583715 D 4932 CDS NP_009736.1 6319655 852476 complement(584802..586157) 1 NC_001134.7 Eht1p; Acyl-coenzymeA:ethanol O-acyltransferase that plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; contains esterase activity; localizes to lipid particles and the mitochondrial outer membrane 586157 EHT1 852476 EHT1 Saccharomyces cerevisiae Acyl-coenzymeA:ethanol O-acyltransferase that plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; contains esterase activity; localizes to lipid particles and the mitochondrial outer membrane NP_009736.1 584802 R 4932 CDS NP_009738.1 6319656 852477 complement(586542..589109) 1 NC_001134.7 Mitochondrial integral membrane protein involved in mitochondrial fusion and maintenance of the mitochondrial genome; contains N-terminal GTPase domain; Fzo1p 589109 FZO1 852477 FZO1 Saccharomyces cerevisiae Fzo1p NP_009738.1 586542 R 4932 CDS NP_009739.1 6319657 852478 589736..591454 1 NC_001134.7 Putative dityrosine transporter, required for spore wall synthesis; expressed during sporulation; member of the major facilitator superfamily (DHA1 family) of multidrug resistance transporters; Dtr1p 591454 DTR1 852478 DTR1 Saccharomyces cerevisiae Dtr1p NP_009739.1 589736 D 4932 CDS NP_009740.1 6319658 852479 complement(join(591707..592411,592764..592769)) 1 NC_001134.7 Rps6bp; Protein component of the small (40S) ribosomal subunit; identical to Rps6Ap and has similarity to rat S6 ribosomal protein 592769 RPS6B 852479 RPS6B Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit; identical to Rps6Ap and has similarity to rat S6 ribosomal protein NP_009740.1 591707 R 4932 CDS NP_009741.1 6319659 852480 complement(593501..594859) 1 NC_001134.7 Smp1p; Putative transcription factor involved in regulating the response to osmotic stress; member of the MADS-box family of transcription factors 594859 SMP1 852480 SMP1 Saccharomyces cerevisiae Putative transcription factor involved in regulating the response to osmotic stress; member of the MADS-box family of transcription factors NP_009741.1 593501 R 4932 CDS NP_878050.1 33438768 1466446 complement(595356..595550) 1 NC_001134.7 Ybr182c-ap; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 595550 1466446 YBR182C-A Saccharomyces cerevisiae Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching NP_878050.1 595356 R 4932 CDS NP_009742.1 6319660 852481 596110..597060 1 NC_001134.7 Ypc1p; Alkaline ceramidase that also has reverse (CoA-independent) ceramide synthase activity, catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance 597060 YPC1 852481 YPC1 Saccharomyces cerevisiae Alkaline ceramidase that also has reverse (CoA-independent) ceramide synthase activity, catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance NP_009742.1 596110 D 4932 CDS NP_009743.1 6319661 852482 597358..598929 1 NC_001134.7 Ybr184wp; Putative protein of unknown function; YBR184W is not an essential gene 598929 852482 YBR184W Saccharomyces cerevisiae Putative protein of unknown function; YBR184W is not an essential gene NP_009743.1 597358 D 4932 CDS NP_009744.1 6319662 852483 complement(599118..599954) 1 NC_001134.7 Protein involved in assembly of mitochondrial respiratory complexes; may act as a receptor for proteins destined for export from the mitochondrial matrix to the inner membrane; Mba1p 599954 MBA1 852483 MBA1 Saccharomyces cerevisiae Mba1p NP_009744.1 599118 R 4932 CDS NP_009745.2 9755327 852484 join(600548..602098,602212..602355) 1 NC_001134.7 Pch2p; Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA 602355 PCH2 852484 PCH2 Saccharomyces cerevisiae Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA NP_009745.2 600548 D 4932 CDS NP_009746.1 6319664 852485 602629..603471 1 NC_001134.7 Putative protein of unknown function; expression is reduced in a gcr1 null mutant; GFP-fusion protein localizes to the vacuole; expression pattern and physical interactions suggest a possible role in ribosome biogenesis; Gdt1p 603471 GDT1 852485 GDT1 Saccharomyces cerevisiae Gdt1p NP_009746.1 602629 D 4932 CDS NP_009747.1 6319665 852486 complement(603680..604102) 1 NC_001134.7 Ntc20p; Member of a complex, including Prp19p, that binds to the spliceosome; required for pre-mRNA splicing 604102 NTC20 852486 NTC20 Saccharomyces cerevisiae Member of a complex, including Prp19p, that binds to the spliceosome; required for pre-mRNA splicing NP_009747.1 603680 R 4932 CDS NP_009748.1 6319666 852487 join(604503..604509,604923..605503) 1 NC_001134.7 Rps9bp; Protein component of the small (40S) ribosomal subunit; nearly identical to Rps9Ap and has similarity to E. coli S4 and rat S9 ribosomal proteins 605503 RPS9B 852487 RPS9B Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit; nearly identical to Rps9Ap and has similarity to E. coli S4 and rat S9 ribosomal proteins NP_009748.1 604503 D 4932 CDS NP_009750.1 6319668 852489 join(606265..606275,606664..607135) 1 NC_001134.7 Rpl21ap; Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Bp and has similarity to rat L21 ribosomal protein 607135 RPL21A 852489 RPL21A Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Bp and has similarity to rat L21 ribosomal protein NP_009750.1 606265 D 4932 CDS NP_009751.1 6319669 852491 607647..608780 1 NC_001134.7 Rim2p; Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family 608780 RIM2 852491 RIM2 Saccharomyces cerevisiae Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family NP_009751.1 607647 D 4932 CDS NP_009752.1 6319670 852492 complement(609077..609748) 1 NC_001134.7 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; Med8p 609748 MED8 852492 MED8 Saccharomyces cerevisiae Med8p NP_009752.1 609077 R 4932 CDS NP_009753.1 6319671 852493 610033..610404 1 NC_001134.7 Protein proposed to be associated with the nuclear pore complex; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and a severe growth defect in minimal glycerol media; Aim4p 610404 AIM4 852493 AIM4 Saccharomyces cerevisiae Aim4p NP_009753.1 610033 D 4932 CDS NP_009754.1 6319672 852494 complement(610609..611877) 1 NC_001134.7 Subunit of chromatin assembly factor I (CAF-1), negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase; localizes to the nucleus and cytoplasm; homologous to human retinoblastoma binding proteins RbAp48 and RbAp46; Msi1p 611877 MSI1 852494 MSI1 Saccharomyces cerevisiae Msi1p NP_009754.1 610609 R 4932 CDS NP_009755.1 6319673 852495 complement(612231..613895) 1 NC_001134.7 Pgi1p; Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation 613895 PGI1 852495 PGI1 Saccharomyces cerevisiae Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation NP_009755.1 612231 R 4932 CDS NP_878051.1 33438769 1466447 complement(614019..614168) 1 NC_001134.7 Ybr196c-ap; Putative protein of unknown function; identified by fungal homology and RT-PCR 614168 1466447 YBR196C-A Saccharomyces cerevisiae Putative protein of unknown function; identified by fungal homology and RT-PCR NP_878051.1 614019 R 4932 CDS NP_878052.1 33438770 1466448 complement(614521..614625) 1 NC_001134.7 Ybr196c-bp; Putative protein of unknown function; identified by expression profiling and mass spectrometry 614625 1466448 YBR196C-B Saccharomyces cerevisiae Putative protein of unknown function; identified by expression profiling and mass spectrometry NP_878052.1 614521 R 4932 CDS NP_009756.1 6319674 852496 complement(615198..615851) 1 NC_001134.7 Ybr197cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene 615851 852496 YBR197C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene NP_009756.1 615198 R 4932 CDS NP_009757.1 6319675 852497 complement(616122..618518) 1 NC_001134.7 Taf5p; Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification 618518 TAF5 852497 TAF5 Saccharomyces cerevisiae Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification NP_009757.1 616122 R 4932 CDS NP_009758.1 6319676 852498 618904..620298 1 NC_001134.7 Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Ktr4p 620298 KTR4 852498 KTR4 Saccharomyces cerevisiae Ktr4p NP_009758.1 618904 D 4932 CDS NP_009759.1 6319677 852499 620867..622522 1 NC_001134.7 Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p; Bem1p 622522 BEM1 852499 BEM1 Saccharomyces cerevisiae Bem1p NP_009759.1 620867 D 4932 CDS NP_878053.1 33438771 1466449 622978..623142 1 NC_001134.7 Ybr200w-ap; Putative protein of unknown function; identified by fungal homology and RT-PCR 623142 1466449 YBR200W-A Saccharomyces cerevisiae Putative protein of unknown function; identified by fungal homology and RT-PCR NP_878053.1 622978 D 4932 CDS NP_009760.1 6319678 852500 623572..624207 1 NC_001134.7 Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p; Der1p 624207 DER1 852500 DER1 Saccharomyces cerevisiae Der1p NP_009760.1 623572 D 4932 CDS NP_001032571.1 82795240 3799967 complement(624489..624692) 1 NC_001134.7 Ybr201c-ap; Putative protein of unknown function 624692 3799967 YBR201C-A Saccharomyces cerevisiae Putative protein of unknown function NP_001032571.1 624489 R 4932 CDS NP_009761.1 6319679 852501 625767..628304 1 NC_001134.7 Mcm7p; Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase 628304 MCM7 852501 MCM7 Saccharomyces cerevisiae Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase NP_009761.1 625767 D 4932 CDS NP_009762.1 6319680 852502 629163..631937 1 NC_001134.7 Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Cos111p 631937 COS111 852502 COS111 Saccharomyces cerevisiae Cos111p NP_009762.1 629163 D 4932 CDS NP_009763.1 6319681 852503 complement(632249..633376) 1 NC_001134.7 Ybr204cp; Serine hydrolase; YBR204C is not an essential gene 633376 852503 YBR204C Saccharomyces cerevisiae Serine hydrolase; YBR204C is not an essential gene NP_009763.1 632249 R 4932 CDS NP_009764.1 6319682 852504 633617..634831 1 NC_001134.7 Putative alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Ktr3p 634831 KTR3 852504 KTR3 Saccharomyces cerevisiae Ktr3p NP_009764.1 633617 D 4932 CDS NP_009766.1 6319684 852506 635141..636538 1 NC_001134.7 Putative high affinity iron transporter involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; Fth1p 636538 FTH1 852506 FTH1 Saccharomyces cerevisiae Fth1p NP_009766.1 635141 D 4932 CDS NP_009767.1 6319685 852507 complement(636698..642205) 1 NC_001134.7 Urea amidolyase, contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; Dur1,2p 642205 DUR1,2 852507 DUR1,2 Saccharomyces cerevisiae Dur1,2p NP_009767.1 636698 R 4932 CDS NP_009769.1 6319687 852511 645545..645973 1 NC_001134.7 Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p; Erv15p 645973 ERV15 852511 ERV15 Saccharomyces cerevisiae Erv15p NP_009769.1 645545 D 4932 CDS NP_009770.1 6319688 852512 complement(646153..647127) 1 NC_001134.7 Essential kinetochore protein associated with microtubules and spindle pole bodies; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance; Ame1p 647127 AME1 852512 AME1 Saccharomyces cerevisiae Ame1p NP_009770.1 646153 R 4932 CDS NP_009771.1 6319689 852513 647881..649899 1 NC_001134.7 RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; expressed in stationary phase; Ngr1p 649899 NGR1 852513 NGR1 Saccharomyces cerevisiae Ngr1p NP_009771.1 647881 D 4932 CDS NP_009772.1 6319690 852514 650363..651187 1 NC_001134.7 Met8p; Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis 651187 MET8 852514 MET8 Saccharomyces cerevisiae Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis NP_009772.1 650363 D 4932 CDS NP_009773.1 6319691 852515 651410..652993 1 NC_001134.7 Sds24p; One of two S. cerevisiae homologs (Sds23p and Sds24p) of the Schizosaccharomyces pombe Sds23 protein, which genetic studies have implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis 652993 SDS24 852515 SDS24 Saccharomyces cerevisiae One of two S. cerevisiae homologs (Sds23p and Sds24p) of the Schizosaccharomyces pombe Sds23 protein, which genetic studies have implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis NP_009773.1 651410 D 4932 CDS NP_009774.2 154199602 852516 join(653351..653363,653448..655312) 1 NC_001134.7 Hpc2p; Highly charged, basic protein required for normal cell-cycle regulation of histone gene transcription; mutants display strong synthetic defects with subunits of FACT, a complex that allows RNA Pol II to elongate through nucleosomes 655312 HPC2 852516 HPC2 Saccharomyces cerevisiae Highly charged, basic protein required for normal cell-cycle regulation of histone gene transcription; mutants display strong synthetic defects with subunits of FACT, a complex that allows RNA Pol II to elongate through nucleosomes NP_009774.2 653351 D 4932 CDS NP_009775.1 6319693 852517 complement(655571..657595) 1 NC_001134.7 Ybp1p; Protein required for oxidation of specific cysteine residues of the transcription factor Yap1p, resulting in the nuclear localization of Yap1p in response to stress 657595 YBP1 852517 YBP1 Saccharomyces cerevisiae Protein required for oxidation of specific cysteine residues of the transcription factor Yap1p, resulting in the nuclear localization of Yap1p in response to stress NP_009775.1 655571 R 4932 CDS NP_009776.1 6319694 852518 657827..658387 1 NC_001134.7 Ubiquitin-like modifier, conjugated via an isopeptide bond to a lysine residue of Atg5p by the E1 enzyme, Atg7p, and the E2 enzyme, Atg10p, a step that is essential for autophagy; Atg12p 658387 ATG12 852518 ATG12 Saccharomyces cerevisiae Atg12p NP_009776.1 657827 D 4932 CDS NP_009777.1 6319695 852519 complement(658702..662244) 1 NC_001134.7 Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc1p but differentially regulated; mutations in the human homolog are associated with lactic acidosis; Pyc2p 662244 PYC2 852519 PYC2 Saccharomyces cerevisiae Pyc2p NP_009777.1 658702 R 4932 CDS NP_009778.1 6319696 852520 complement(join(662494..662576,662998..663298)) 1 NC_001134.7 Ybr219cp; Putative protein of unknown function; YBR219C is not an essential gene 663298 852520 YBR219C Saccharomyces cerevisiae Putative protein of unknown function; YBR219C is not an essential gene NP_009778.1 662494 R 4932 CDS NP_009779.1 6319697 852521 complement(662990..664672) 1 NC_001134.7 Ybr220cp; Putative protein of unknown function; YBR220C is not an essential gene 664672 852521 YBR220C Saccharomyces cerevisiae Putative protein of unknown function; YBR220C is not an essential gene NP_009779.1 662990 R 4932 CDS NP_009780.1 6319698 852522 complement(665148..666248) 1 NC_001134.7 Pdb1p; E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria 666248 PDB1 852522 PDB1 Saccharomyces cerevisiae E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria NP_009780.1 665148 R 4932 CDS NP_878054.1 33438772 1466450 666533..666637 1 NC_001134.7 Ybr221w-ap; Putative protein of unknown function; identified by expression profiling and mass spectrometry 666637 1466450 YBR221W-A Saccharomyces cerevisiae Putative protein of unknown function; identified by expression profiling and mass spectrometry NP_878054.1 666533 D 4932 CDS NP_009781.1 6319699 852523 complement(666715..668346) 1 NC_001134.7 Peroxisomal AMP-binding protein, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase; Pcs60p 668346 PCS60 852523 PCS60 Saccharomyces cerevisiae Pcs60p NP_009781.1 666715 R 4932 CDS NP_009782.1 6319701 852525 complement(668658..670292) 1 NC_001134.7 Tyrosyl-DNA Phosphodiesterase I, hydrolyzes 3'-phosphotyrosyl bonds to generate 3'-phosphate DNA and tyrosine, involved in the repair of DNA lesions created by topoisomerase I; Tdp1p 670292 TDP1 852525 TDP1 Saccharomyces cerevisiae Tdp1p NP_009782.1 668658 R 4932 CDS NP_009784.1 6319702 852526 670622..673324 1 NC_001134.7 Ybr225wp; Putative protein of unknown function; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components 673324 852526 YBR225W Saccharomyces cerevisiae Putative protein of unknown function; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components NP_009784.1 670622 D 4932 CDS NP_009786.1 6319704 852528 complement(673567..675129) 1 NC_001134.7 Mitochondrial ATP-binding protein, possibly a mitochondrial chaperone with non-proteolytic function; similar to bacterial ClpX proteins; Mcx1p 675129 MCX1 852528 MCX1 Saccharomyces cerevisiae Mcx1p NP_009786.1 673567 R 4932 CDS NP_009787.1 6319705 852529 675308..676222 1 NC_001134.7 Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p; Slx1p 676222 SLX1 852529 SLX1 Saccharomyces cerevisiae Slx1p NP_009787.1 675308 D 4932 CDS NP_009788.1 6319706 852530 complement(676352..679216) 1 NC_001134.7 Rot2p; Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations 679216 ROT2 852530 ROT2 Saccharomyces cerevisiae Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations NP_009788.1 676352 R 4932 CDS NP_009789.1 6319707 852531 complement(join(679544..679937,680035..680045)) 1 NC_001134.7 Om14p; Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron 680045 OM14 852531 OM14 Saccharomyces cerevisiae Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron NP_009789.1 679544 R 4932 CDS NP_001018029.1 63148619 2777172 680357..680557 1 NC_001134.7 Ybr230w-ap; Putative protein of unknown function 680557 2777172 YBR230W-A Saccharomyces cerevisiae Putative protein of unknown function NP_001018029.1 680357 D 4932 CDS NP_009790.1 6319708 852532 complement(682174..683085) 1 NC_001134.7 Swc5p; Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A 683085 SWC5 852532 SWC5 Saccharomyces cerevisiae Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A NP_009790.1 682174 R 4932 CDS NP_009792.1 6319709 852533 683423..684664 1 NC_001134.7 RNA binding protein with similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length; Pbp2p 684664 PBP2 852533 PBP2 Saccharomyces cerevisiae Pbp2p NP_009792.1 683423 D 4932 CDS NP_631876.1 21450619 852535 684972..685256 1 NC_001134.7 Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis; Dad3p 685256 DAD3 852535 DAD3 Saccharomyces cerevisiae Dad3p NP_631876.1 684972 D 4932 CDS NP_009793.1 6319711 852536 complement(685433..686587) 1 NC_001134.7 Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; Arc40p 686587 ARC40 852536 ARC40 Saccharomyces cerevisiae Arc40p NP_009793.1 685433 R 4932 CDS NP_009794.1 6319712 852537 686896..690258 1 NC_001134.7 Ybr235wp; Putative ion transporter, similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family; YBR235W is not an essential gene 690258 852537 YBR235W Saccharomyces cerevisiae Putative ion transporter, similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family; YBR235W is not an essential gene NP_009794.1 686896 D 4932 CDS NP_009795.1 6319713 852538 complement(690378..691688) 1 NC_001134.7 Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA; Abd1p 691688 ABD1 852538 ABD1 Saccharomyces cerevisiae Abd1p NP_009795.1 690378 R 4932 CDS NP_009796.1 6319714 852539 691964..694513 1 NC_001134.7 RNA helicase in the DEAD-box family, necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA; Prp5p 694513 PRP5 852539 PRP5 Saccharomyces cerevisiae Prp5p NP_009796.1 691964 D 4932 CDS NP_009797.1 6319715 852540 complement(695102..697297) 1 NC_001134.7 Ybr238cp; Mitochondrial membrane protein with similarity to Rmd9p; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span 697297 852540 YBR238C Saccharomyces cerevisiae Mitochondrial membrane protein with similarity to Rmd9p; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span NP_009797.1 695102 R 4932 CDS NP_009798.1 6319716 852541 complement(698349..699938) 1 NC_001134.7 Ybr239cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR239C is not an essential gene 699938 852541 YBR239C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR239C is not an essential gene NP_009798.1 698349 R 4932 CDS NP_009799.1 6319717 852542 complement(700485..701837) 1 NC_001134.7 Zinc finger protein of the Zn(II)2Cys6 type, probable transcriptional activator of thiamine biosynthetic genes; Thi2p 701837 THI2 852542 THI2 Saccharomyces cerevisiae Thi2p NP_009799.1 700485 R 4932 CDS NP_009800.1 6319718 852543 complement(702584..704050) 1 NC_001134.7 Ybr241cp; Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene 704050 852543 YBR241C Saccharomyces cerevisiae Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene NP_009800.1 702584 R 4932 CDS NP_009801.1 6319719 852544 704665..705381 1 NC_001134.7 Ybr242wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene 705381 852544 YBR242W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene NP_009801.1 704665 D 4932 CDS NP_009802.1 6319720 852545 complement(705442..706788) 1 NC_001134.7 UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin; Alg7p 706788 ALG7 852545 ALG7 Saccharomyces cerevisiae Alg7p NP_009802.1 705442 R 4932 CDS NP_009803.1 6319721 852546 707523..708011 1 NC_001134.7 Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; Gpx2p 708011 GPX2 852546 GPX2 Saccharomyces cerevisiae Gpx2p NP_009803.1 707523 D 4932 CDS NP_009804.1 6319722 852547 complement(708145..711534) 1 NC_001134.7 Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase that forms a complex with Ioc2p and Ioc4p to regulate transcription elongation, and a complex with Ioc3p to repress transcription initiation; Isw1p 711534 ISW1 852547 ISW1 Saccharomyces cerevisiae Isw1p NP_009804.1 708145 R 4932 CDS NP_009805.1 6319723 852548 711586..712749 1 NC_001134.7 Ybr246wp; Putative protein of unknown function; deletion results in a weak carboxypeptidase Y missorting/secretion phenotype; YBR246W is not an essential gene 712749 852548 YBR246W Saccharomyces cerevisiae Putative protein of unknown function; deletion results in a weak carboxypeptidase Y missorting/secretion phenotype; YBR246W is not an essential gene NP_009805.1 711586 D 4932 CDS NP_009806.1 6319724 852549 complement(712999..714450) 1 NC_001134.7 Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus; Enp1p 714450 ENP1 852549 ENP1 Saccharomyces cerevisiae Enp1p NP_009806.1 712999 R 4932 CDS NP_009807.1 6319725 852550 complement(714802..716460) 1 NC_001134.7 Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase), catalyzes the fifth and sixth steps of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor; His7p 716460 HIS7 852550 HIS7 Saccharomyces cerevisiae His7p NP_009807.1 714802 R 4932 CDS NP_009808.1 6319726 852551 complement(716877..717989) 1 NC_001134.7 Aro4p; 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan 717989 ARO4 852551 ARO4 Saccharomyces cerevisiae 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan NP_009808.1 716877 R 4932 CDS NP_009809.1 6319727 852552 719028..720599 1 NC_001134.7 Spo23p; Protein of unknown function; associates with meiosis-specific protein Spo1p 720599 SPO23 852552 SPO23 Saccharomyces cerevisiae Protein of unknown function; associates with meiosis-specific protein Spo1p NP_009809.1 719028 D 4932 CDS NP_009810.1 6319728 852553 721385..722308 1 NC_001134.7 Mrps5p; Mitochondrial ribosomal protein of the small subunit 722308 MRPS5 852553 MRPS5 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the small subunit NP_009810.1 721385 D 4932 CDS NP_009811.1 6319729 852554 722606..723049 1 NC_001134.7 dUTPase, catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; Dut1p 723049 DUT1 852554 DUT1 Saccharomyces cerevisiae Dut1p NP_009811.1 722606 D 4932 CDS NP_009812.1 6319730 852555 723265..723630 1 NC_001134.7 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; Srb6p 723630 SRB6 852555 SRB6 Saccharomyces cerevisiae Srb6p NP_009812.1 723265 D 4932 CDS NP_009813.1 6319731 852556 complement(723731..724258) 1 NC_001134.7 Trs20p; One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; mutations in the human homolog cause the spondyloepiphyseal dysplasia tarda (SEDL) disorder 724258 TRS20 852556 TRS20 Saccharomyces cerevisiae One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; mutations in the human homolog cause the spondyloepiphyseal dysplasia tarda (SEDL) disorder NP_009813.1 723731 R 4932 CDS NP_009814.1 6319732 852557 724451..726535 1 NC_001134.7 Ybr255wp; Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 726535 852557 YBR255W Saccharomyces cerevisiae Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern NP_009814.1 724451 D 4932 CDS NP_116328.2 41629679 852558 complement(join(726613..726912,727007..727069)) 1 NC_001134.7 Ybr255c-ap; Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species 727069 852558 YBR255C-A Saccharomyces cerevisiae Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species NP_116328.2 726613 R 4932 CDS NP_009815.1 6319733 852559 complement(727381..728097) 1 NC_001134.7 Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway; Rib5p 728097 RIB5 852559 RIB5 Saccharomyces cerevisiae Rib5p NP_009815.1 727381 R 4932 CDS NP_009816.1 6319734 852560 728880..729719 1 NC_001134.7 Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; binds to the RPR1 RNA subunit in Rnase P; Pop4p 729719 POP4 852560 POP4 Saccharomyces cerevisiae Pop4p NP_009816.1 728880 D 4932 CDS NP_009817.1 6319735 852561 complement(729729..730157) 1 NC_001134.7 Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; Shg1p 730157 SHG1 852561 SHG1 Saccharomyces cerevisiae Shg1p NP_009817.1 729729 R 4932 CDS NP_009818.1 6319736 852562 730382..732448 1 NC_001134.7 Ybr259wp; Putative protein of unknown function; YBR259W is not an essential gene 732448 852562 YBR259W Saccharomyces cerevisiae Putative protein of unknown function; YBR259W is not an essential gene NP_009818.1 730382 D 4932 CDS NP_009819.1 6319737 852563 complement(732634..734634) 1 NC_001134.7 Rgd1p; GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization 734634 RGD1 852563 RGD1 Saccharomyces cerevisiae GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization NP_009819.1 732634 R 4932 CDS NP_009820.1 6319738 852564 complement(734827..735525) 1 NC_001134.7 Ybr261cp; Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YBR261C is not an essential gene 735525 852564 YBR261C Saccharomyces cerevisiae Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YBR261C is not an essential gene NP_009820.1 734827 R 4932 CDS NP_009821.1 6319740 852566 complement(735715..736035) 1 NC_001134.7 Protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss and reduced growth rate in minimal glycerol media; Aim5p 736035 AIM5 852566 AIM5 Saccharomyces cerevisiae Aim5p NP_009821.1 735715 R 4932 CDS NP_009822.2 37362622 852565 736259..737731 1 NC_001134.7 Shm1p; Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine 737731 SHM1 852565 SHM1 Saccharomyces cerevisiae Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine NP_009822.2 736259 D 4932 CDS NP_009823.2 37362623 852567 complement(737765..738364) 1 NC_001134.7 Ypt10p; GTP binding protein that contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles 738364 YPT10 852567 YPT10 Saccharomyces cerevisiae GTP binding protein that contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles NP_009823.2 737765 R 4932 CDS NP_009824.1 6319742 852568 738577..739539 1 NC_001134.7 Tsc10p; 3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family 739539 TSC10 852568 TSC10 Saccharomyces cerevisiae 3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family NP_009824.1 738577 D 4932 CDS NP_009825.1 6319743 852569 739836..741017 1 NC_001134.7 Rei1p; Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network 741017 REI1 852569 REI1 Saccharomyces cerevisiae Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network NP_009825.1 739836 D 4932 CDS NP_009827.1 6319745 852571 741294..741611 1 NC_001134.7 Mrpl37p; Mitochondrial ribosomal protein of the large subunit 741611 MRPL37 852571 MRPL37 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit NP_009827.1 741294 D 4932 CDS NP_009828.2 41629680 852572 complement(742155..742571) 1 NC_001134.7 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Fmp21p 742571 FMP21 852572 FMP21 Saccharomyces cerevisiae Fmp21p NP_009828.2 742155 R 4932 CDS NP_009829.1 6319747 852573 complement(742756..744393) 1 NC_001134.7 Bit2p 744393 BIT2 852573 BIT2 Saccharomyces cerevisiae Bit2p NP_009829.1 742756 R 4932 CDS NP_009830.1 6319748 852574 744847..746106 1 NC_001134.7 Ybr271wp; Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YBR271W is not as essential gene 746106 852574 YBR271W Saccharomyces cerevisiae Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YBR271W is not as essential gene NP_009830.1 744847 D 4932 CDS NP_009831.1 6319749 852575 complement(746356..747798) 1 NC_001134.7 Protein of unknown function, involved in DNA mismatch repair during slow growth; has weak similarity to Msh1p; Hsm3p 747798 HSM3 852575 HSM3 Saccharomyces cerevisiae Hsm3p NP_009831.1 746356 R 4932 CDS NP_009832.1 6319750 852576 complement(748056..749366) 1 NC_001134.7 Ubx7p; UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p 749366 UBX7 852576 UBX7 Saccharomyces cerevisiae UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p NP_009832.1 748056 R 4932 CDS NP_009833.1 6319751 852577 749589..751172 1 NC_001134.7 Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase; Chk1p 751172 CHK1 852577 CHK1 Saccharomyces cerevisiae Chk1p NP_009833.1 749589 D 4932 CDS NP_009834.1 6319752 852578 complement(751351..757101) 1 NC_001134.7 Rif1p; Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation 757101 RIF1 852578 RIF1 Saccharomyces cerevisiae Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation NP_009834.1 751351 R 4932 CDS NP_009835.1 6319753 852579 complement(757616..760039) 1 NC_001134.7 Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle; Pps1p 760039 PPS1 852579 PPS1 Saccharomyces cerevisiae Pps1p NP_009835.1 757616 R 4932 CDS NP_009837.1 6319754 852580 760290..760895 1 NC_001134.7 Third-largest subunit of DNA polymerase II (DNA polymerase epsilon), required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; mRNA abundance peaks at the G1/S boundary of the cell cycle; Dpb3p 760895 DPB3 852580 DPB3 Saccharomyces cerevisiae Dpb3p NP_009837.1 760290 D 4932 CDS NP_009838.1 6319756 852582 761253..762590 1 NC_001134.7 RNAP II-associated protein; defines large complex biochemically and functionally distinct from the Srb-Mediator form of Pol II holoenzyme; required for full expression of a subset of cell cycle-regulated genes; homolog of human PD2/hPAF1; Paf1p 762590 PAF1 852582 PAF1 Saccharomyces cerevisiae Paf1p NP_009838.1 761253 D 4932 CDS NP_009839.2 37362624 852583 complement(762780..764693) 1 NC_001134.7 Saf1p; F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1 764693 SAF1 852583 SAF1 Saccharomyces cerevisiae F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1 NP_009839.2 762780 R 4932 CDS NP_009840.1 6319758 852584 complement(764966..767602) 1 NC_001134.7 Probable di- and tri-peptidase; forms a complex with Dug1p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p); Dug2p 767602 DUG2 852584 DUG2 Saccharomyces cerevisiae Dug2p NP_009840.1 764966 R 4932 CDS NP_009841.1 6319759 852585 768236..768676 1 NC_001134.7 Mrpl27p; Mitochondrial ribosomal protein of the large subunit 768676 MRPL27 852585 MRPL27 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit NP_009841.1 768236 D 4932 CDS NP_009842.1 6319760 852586 complement(768939..770411) 1 NC_001134.7 Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential; Ssh1p 770411 SSH1 852586 SSH1 Saccharomyces cerevisiae Ssh1p NP_009842.1 768939 R 4932 CDS NP_009843.1 6319761 852587 771235..773628 1 NC_001134.7 Ybr284wp; Putative protein of unknown function; YBR284W is not an essential gene; null mutant exhibits decreased resistance to rapamycin and wortmannin 773628 852587 YBR284W Saccharomyces cerevisiae Putative protein of unknown function; YBR284W is not an essential gene; null mutant exhibits decreased resistance to rapamycin and wortmannin NP_009843.1 771235 D 4932 CDS NP_009844.1 6319762 852588 773918..774352 1 NC_001134.7 Ybr285wp; Putative protein of unknown function; YBR285W is not an essential gene and deletion of YBR285W leads to poor growth on glucose-minimal medium at 15C 774352 852588 YBR285W Saccharomyces cerevisiae Putative protein of unknown function; YBR285W is not an essential gene and deletion of YBR285W leads to poor growth on glucose-minimal medium at 15C NP_009844.1 773918 D 4932 CDS NP_009845.2 82795241 852589 774696..776309 1 NC_001134.7 Vacuolar aminopeptidase Y, processed to mature form by Prb1p; Ape3p 776309 APE3 852589 APE3 Saccharomyces cerevisiae Ape3p NP_009845.2 774696 D 4932 CDS NP_009846.1 6319764 852590 776567..777850 1 NC_001134.7 Ybr287wp; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene 777850 852590 YBR287W Saccharomyces cerevisiae Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene NP_009846.1 776567 D 4932 CDS NP_009847.1 6319765 852591 complement(778008..779459) 1 NC_001134.7 Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; Apm3p 779459 APM3 852591 APM3 Saccharomyces cerevisiae Apm3p NP_009847.1 778008 R 4932 CDS NP_009848.1 6319766 852592 779663..782380 1 NC_001134.7 Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p; Snf5p 782380 SNF5 852592 SNF5 Saccharomyces cerevisiae Snf5p NP_009848.1 779663 D 4932 CDS NP_009849.1 6319767 852593 782587..783552 1 NC_001134.7 Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification; Bsd2p 783552 BSD2 852593 BSD2 Saccharomyces cerevisiae Bsd2p NP_009849.1 782587 D 4932 CDS NP_009850.1 6319768 852594 complement(783669..784568) 1 NC_001134.7 Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family; Ctp1p 784568 CTP1 852594 CTP1 Saccharomyces cerevisiae Ctp1p NP_009850.1 783669 R 4932 CDS NP_009852.1 6319770 852596 787001..788425 1 NC_001134.7 Vba2p; Permease of basic amino acids in the vacuolar membrane 788425 VBA2 852596 VBA2 Saccharomyces cerevisiae Permease of basic amino acids in the vacuolar membrane NP_009852.1 787001 D 4932 CDS NP_009853.1 6319771 852597 789230..791809 1 NC_001134.7 Sul1p; High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates 791809 SUL1 852597 SUL1 Saccharomyces cerevisiae High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates NP_009853.1 789230 D 4932 CDS NP_009854.1 6319772 852598 792843..796493 1 NC_001134.7 Pca1p; Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; S288C and most other lab strains contain a G970R mutation which eliminates normal cadmium transport function 796493 PCA1 852598 PCA1 Saccharomyces cerevisiae Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; S288C and most other lab strains contain a G970R mutation which eliminates normal cadmium transport function NP_009854.1 792843 D 4932 CDS NP_009855.1 6319773 852599 complement(796792..798516) 1 NC_001134.7 Pho89p; Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p 798516 PHO89 852599 PHO89 Saccharomyces cerevisiae Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p NP_009855.1 796792 R 4932 CDS NP_878055.1 33438773 1466451 complement(800117..800236) 1 NC_001134.7 Ybr296c-ap; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 800236 1466451 YBR296C-A Saccharomyces cerevisiae Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching NP_878055.1 800117 R 4932 CDS NP_009856.1 6319774 852600 800517..801923 1 NC_001134.7 Mal33p; MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C 801923 MAL33 852600 MAL33 Saccharomyces cerevisiae MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C NP_009856.1 800517 D 4932 CDS NP_009857.1 6319775 852601 complement(802625..804469) 1 NC_001134.7 Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C; Mal31p 804469 MAL31 852601 MAL31 Saccharomyces cerevisiae Mal31p NP_009857.1 802625 R 4932 CDS NP_878056.1 33438774 1466452 complement(805029..805250) 1 NC_001134.7 Ybr298c-ap; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 805250 1466452 YBR298C-A Saccharomyces cerevisiae Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching NP_878056.1 805029 R 4932 CDS NP_009858.1 6319776 852602 805345..807099 1 NC_001134.7 Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; Mal32p 807099 MAL32 852602 MAL32 Saccharomyces cerevisiae Mal32p NP_009858.1 805345 D 4932 CDS NP_009860.1 6319777 852603 809051..809413 1 NC_001134.7 Dan3p; Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth 809413 DAN3 852603 DAN3 Saccharomyces cerevisiae Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth NP_009860.1 809051 D 4932 CDS NP_009861.1 6319779 852605 complement(810334..811473) 1 NC_001134.7 Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; Cos2p 811473 COS2 852605 COS2 Saccharomyces cerevisiae Cos2p NP_009861.1 810334 R 4932 CDS NP_009863.2 10383750 850289 complement(6479..8326) 1 NC_001135.4 Ycl073cp; Protein of unconfirmed function; displays a topology characteristic of the Major Facilitators Superfamily of membrane proteins; coding sequence 98% identical to that of YKR106W 8326 850289 YCL073C Saccharomyces cerevisiae Protein of unconfirmed function; displays a topology characteristic of the Major Facilitators Superfamily of membrane proteins; coding sequence 98% identical to that of YKR106W NP_009863.2 6479 R 4932 CDS NP_009864.1 6319783 850290 9706..11082 1 NC_001135.4 Vba3p; Permease of basic amino acids in the vacuolar membrane 11082 VBA3 850290 VBA3 Saccharomyces cerevisiae Permease of basic amino acids in the vacuolar membrane NP_009864.1 9706 D 4932 CDS NP_009865.2 10383751 850291 complement(11503..12285) 1 NC_001135.4 Ycl068cp; Putative protein of unknown function 12285 850291 YCL068C Saccharomyces cerevisiae Putative protein of unknown function NP_009865.2 11503 R 4932 CDS NP_009866.1 6319785 850292 complement(12386..13018) 1 NC_001135.4 Silenced copy of ALPHA2 at HML; homeobox-domain protein that associates with Mcm1p in haploid cells to repress a-specific gene expression and interacts with a1p in diploid cells to repress haploid-specific gene expression; Hmlalpha2p 13018 HMLALPHA2 850292 HMLALPHA2 Saccharomyces cerevisiae Hmlalpha2p NP_009866.1 12386 R 4932 CDS NP_009867.1 6319786 850293 13282..13809 1 NC_001135.4 Silenced copy of ALPHA1 at HML, encoding a transcriptional coactivator involved in the regulation of mating-type alpha-specific gene expression; Hmlalpha1p 13809 HMLALPHA1 850293 HMLALPHA1 Saccharomyces cerevisiae Hmlalpha1p NP_009867.1 13282 D 4932 CDS NP_001018030.1 63535562 850295 complement(15798..16880) 1 NC_001135.4 Cha1p; Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine 16880 CHA1 850295 CHA1 Saccharomyces cerevisiae Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine NP_001018030.1 15798 R 4932 CDS NP_009870.1 6319789 850296 17290..18561 1 NC_001135.4 Vac17p; Protein involved in vacuole inheritance; acts as a vacuole-specific receptor for myosin Myo2p 18561 VAC17 850296 VAC17 Saccharomyces cerevisiae Protein involved in vacuole inheritance; acts as a vacuole-specific receptor for myosin Myo2p NP_009870.1 17290 D 4932 CDS NP_009871.2 10383754 850297 complement(18816..22106) 1 NC_001135.4 S-phase checkpoint protein found at replication forks, required for DNA replication; also required for Rad53p activation during DNA replication stress, where it forms a replication-pausing complex with Tof1p and is phosphorylated by Mec1p; Mrc1p 22106 MRC1 850297 MRC1 Saccharomyces cerevisiae Mrc1p NP_009871.2 18816 R 4932 CDS NP_009872.1 6319791 850298 complement(22429..23379) 1 NC_001135.4 Krr1p; Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit 23379 KRR1 850298 KRR1 Saccharomyces cerevisiae Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit NP_009872.1 22429 R 4932 CDS NP_001018031.2 85666112 3289591 23584..23925 1 NC_001135.4 Ycl058w-ap; Protein of unknown function; identified by homology to Ashbya gossypii 23925 3289591 YCL058W-A Saccharomyces cerevisiae Protein of unknown function; identified by homology to Ashbya gossypii NP_001018031.2 23584 D 4932 CDS NP_065435.1 10383755 850300 complement(24032..24325) 1 NC_001135.4 Ycl057c-ap; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 24325 850300 YCL057C-A Saccharomyces cerevisiae Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_065435.1 24032 R 4932 CDS NP_009874.1 6319793 850301 24768..26906 1 NC_001135.4 Zinc metalloendopeptidase, found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins; Prd1p 26906 PRD1 850301 PRD1 Saccharomyces cerevisiae Prd1p NP_009874.1 24768 D 4932 CDS NP_009875.1 6319794 850302 complement(26925..27359) 1 NC_001135.4 Ycl056cp; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 27359 850302 YCL056C Saccharomyces cerevisiae Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern NP_009875.1 26925 R 4932 CDS NP_009876.1 6319795 850303 27929..28936 1 NC_001135.4 Transcription factor required for gene regulation in repsonse to pheromones; also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone; Kar4p 28936 KAR4 850303 KAR4 Saccharomyces cerevisiae Kar4p NP_009876.1 27929 D 4932 CDS NP_009877.1 6319796 850304 31449..33974 1 NC_001135.4 Spb1p; AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants 33974 SPB1 850304 SPB1 Saccharomyces cerevisiae AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants NP_009877.1 31449 D 4932 CDS NP_009878.1 6319797 850305 complement(34143..35393) 1 NC_001135.4 Pbn1p; Essential component of glycosylphosphatidylinositol-mannosyltransferase I, required for the autocatalytic post-translational processing of the protease B precursor Prb1p, localizes to ER in lumenal orientation; homolog of mammalian PIG-X 35393 PBN1 850305 PBN1 Saccharomyces cerevisiae Essential component of glycosylphosphatidylinositol-mannosyltransferase I, required for the autocatalytic post-translational processing of the protease B precursor Prb1p, localizes to ER in lumenal orientation; homolog of mammalian PIG-X NP_009878.1 34143 R 4932 CDS NP_009879.2 10383756 850306 35865..37616 1 NC_001135.4 Protein involved in control of cell wall structure and stress response; inhibits Cbk1p protein kinase activity; overproduction confers resistance to cell-wall degrading enzymes; Lre1p 37616 LRE1 850306 LRE1 Saccharomyces cerevisiae Lre1p NP_009879.2 35865 D 4932 CDS NP_009880.2 10383757 850307 complement(37836..38801) 1 NC_001135.4 Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase I (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa2p; Apa1p 38801 APA1 850307 APA1 Saccharomyces cerevisiae Apa1p NP_009880.2 37836 R 4932 CDS NP_009881.2 10383758 850308 complement(39786..40724) 1 NC_001135.4 Ycl049cp; Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene 40724 850308 YCL049C Saccharomyces cerevisiae Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene NP_009881.2 39786 R 4932 CDS NP_001032573.1 82795242 3799968 41488..41727 1 NC_001135.4 Ycl048w-ap; Putative protein of unknown function 41727 3799968 YCL048W-A Saccharomyces cerevisiae Putative protein of unknown function NP_001032573.1 41488 D 4932 CDS NP_009882.1 6319801 850309 42165..43556 1 NC_001135.4 Sps22p; Protein of unknown function, redundant with Sps2p for the organization of the beta-glucan layer of the spore wall 43556 SPS22 850309 SPS22 Saccharomyces cerevisiae Protein of unknown function, redundant with Sps2p for the organization of the beta-glucan layer of the spore wall NP_009882.1 42165 D 4932 CDS NP_009883.1 6319802 850310 complement(43661..44437) 1 NC_001135.4 Ycl047cp; Putative protein of unknown function 44437 850310 YCL047C Saccharomyces cerevisiae Putative protein of unknown function NP_009883.1 43661 R 4932 CDS NP_009884.1 6319804 850312 complement(44623..46905) 1 NC_001135.4 Ycl045cp; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; interacts with Gal80p; YCL045C is not an essential gene 46905 850312 YCL045C Saccharomyces cerevisiae Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; interacts with Gal80p; YCL045C is not an essential gene NP_009884.1 44623 R 4932 CDS NP_009886.1 6319805 850313 complement(47111..48364) 1 NC_001135.4 Subunit, with Yme1p, of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; required for growth of cells lacking the mitochondrial genome; Mgr1p 48364 MGR1 850313 MGR1 Saccharomyces cerevisiae Mgr1p NP_009886.1 47111 R 4932 CDS NP_009887.1 6319806 850314 complement(48653..50221) 1 NC_001135.4 Protein disulfide isomerase, multifunctional protein resident in the endoplasmic reticulum lumen, essential for the formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-native disulfide bonds; Pdi1p 50221 PDI1 850314 PDI1 Saccharomyces cerevisiae Pdi1p NP_009887.1 48653 R 4932 CDS NP_009889.2 10383759 850315 50584..50943 1 NC_001135.4 Ycl042wp; Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm 50943 850315 YCL042W Saccharomyces cerevisiae Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm NP_009889.2 50584 D 4932 CDS NP_009890.1 6319809 850317 50838..52340 1 NC_001135.4 Glucokinase, catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources; Glk1p 52340 GLK1 850317 GLK1 Saccharomyces cerevisiae Glk1p NP_009890.1 50838 D 4932 CDS NP_009891.1 6319810 850318 52645..54882 1 NC_001135.4 Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions; Gid7p 54882 GID7 850318 GID7 Saccharomyces cerevisiae Gid7p NP_009891.1 52645 D 4932 CDS NP_009892.1 6319811 850319 complement(54941..56527) 1 NC_001135.4 Protein required for the breakdown of autophagic vesicles in the vacuole during autophagy, putative integral membrane protein that localizes to vacuolar membranes and punctate structures attached to the vacuole; Atg22p 56527 ATG22 850319 ATG22 Saccharomyces cerevisiae Atg22p NP_009892.1 54941 R 4932 CDS NP_009893.2 37362625 850320 complement(57374..58678) 1 NC_001135.4 Sro9p; Cytoplasmic RNA-binding protein that associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif 58678 SRO9 850320 SRO9 Saccharomyces cerevisiae Cytoplasmic RNA-binding protein that associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif NP_009893.2 57374 R 4932 CDS NP_009894.1 6319813 850321 59026..60726 1 NC_001135.4 Protein of unknown function, identified as a high-copy suppressor of a dbp5 mutation; Gfd2p 60726 GFD2 850321 GFD2 Saccharomyces cerevisiae Gfd2p NP_009894.1 59026 D 4932 CDS NP_009895.1 6319814 850322 complement(60841..61173) 1 NC_001135.4 Hydroperoxide and superoxide-radical responsive heat-stable glutathione-dependent disulfide oxidoreductase with active site cysteine pair; protects cells from oxidative damage; Grx1p 61173 GRX1 850322 GRX1 Saccharomyces cerevisiae Grx1p NP_009895.1 60841 R 4932 CDS NP_009896.2 10383760 850323 61658..62722 1 NC_001135.4 Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; Lsb5p 62722 LSB5 850323 LSB5 Saccharomyces cerevisiae Lsb5p NP_009896.2 61658 D 4932 CDS NP_009897.1 6319816 850324 complement(62776..63282) 1 NC_001135.4 Ycl033cp; Putative protein-methionine-R-oxide reductase; involved in response to oxidative stress; similar to mouse Sepx1p and fly SelRp; YCL033C is not an essential gene 63282 850324 YCL033C Saccharomyces cerevisiae Putative protein-methionine-R-oxide reductase; involved in response to oxidative stress; similar to mouse Sepx1p and fly SelRp; YCL033C is not an essential gene NP_009897.1 62776 R 4932 CDS NP_009898.1 6319817 850325 63441..64481 1 NC_001135.4 Ste50p; Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction 64481 STE50 850325 STE50 Saccharomyces cerevisiae Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction NP_009898.1 63441 D 4932 CDS NP_009899.1 6319818 850326 complement(64675..65568) 1 NC_001135.4 Rrp7p; Essential protein involved in rRNA processing and ribosome biogenesis 65568 RRP7 850326 RRP7 Saccharomyces cerevisiae Essential protein involved in rRNA processing and ribosome biogenesis NP_009899.1 64675 R 4932 CDS NP_009900.2 10383761 850327 complement(65934..68333) 1 NC_001135.4 Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis; His4p 68333 HIS4 850327 HIS4 Saccharomyces cerevisiae His4p NP_009900.2 65934 R 4932 CDS NP_009901.1 6319820 850328 complement(68599..69921) 1 NC_001135.4 Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170; Bik1p 69921 BIK1 850328 BIK1 Saccharomyces cerevisiae Bik1p NP_009901.1 68599 R 4932 CDS NP_009902.2 10383762 850329 70150..71367 1 NC_001135.4 [PIN(+)] prion, an infectious protein conformation that is generally an ordered protein aggregate; Rnq1p 71367 RNQ1 850329 RNQ1 Saccharomyces cerevisiae Rnq1p NP_009902.2 70150 D 4932 CDS NP_009903.2 10383763 850330 71803..73341 1 NC_001135.4 Membrane protein localized to the shmoo tip, required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrate; Fus1p 73341 FUS1 850330 FUS1 Saccharomyces cerevisiae Fus1p NP_009903.2 71803 D 4932 CDS NP_065436.1 10383764 850331 complement(73405..73986) 1 NC_001135.4 Putative protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; Hbn1p 73986 HBN1 850331 HBN1 Saccharomyces cerevisiae Hbn1p NP_065436.1 73405 R 4932 CDS NP_009904.2 10383765 850332 complement(74704..75285) 1 NC_001135.4 Protein of unknown function, involved in the integration of lipid signaling pathways with cellular homeostasis; similar to bacterial nitroreductases; Frm2p 75285 FRM2 850332 FRM2 Saccharomyces cerevisiae Frm2p NP_009904.2 74704 R 4932 CDS NP_009905.3 85666113 850333 complement(76018..77919) 1 NC_001135.4 Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); Agp1p 77919 AGP1 850333 AGP1 Saccharomyces cerevisiae Agp1p NP_009905.3 76018 R 4932 CDS NP_009907.2 10383767 850334 79162..82275 1 NC_001135.4 Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p; Kcc4p 82275 KCC4 850334 KCC4 Saccharomyces cerevisiae Kcc4p NP_009907.2 79162 D 4932 CDS NP_065437.1 10383769 850338 83620..83997 1 NC_001135.4 Ycl021w-ap; Putative protein of unknown function 83997 850338 YCL021W-A Saccharomyces cerevisiae Putative protein of unknown function NP_065437.1 83620 D 4932 CDS NP_009909.2 10383770 850340 join(85102..86391,86393..90415) 1 NC_001135.4 Ycl019wp; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 90415 850340 YCL019W Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_009909.2 85102 D 4932 CDS NP_009910.2 10383771 850339 85102..86418 1 NC_001135.4 Ycl020wp; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 86418 850339 YCL020W Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_009910.2 85102 D 4932 CDS NP_009911.2 10383772 850342 91324..92418 1 NC_001135.4 Leu2p; Beta-isopropylmalate dehydrogenase (IMDH), catalyzes the third step in the leucine biosynthesis pathway 92418 LEU2 850342 LEU2 Saccharomyces cerevisiae Beta-isopropylmalate dehydrogenase (IMDH), catalyzes the third step in the leucine biosynthesis pathway NP_009911.2 91324 D 4932 CDS NP_009912.2 10383773 850343 complement(92777..94270) 1 NC_001135.4 Nfs1p; Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis; required for the post-transcriptional thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria 94270 NFS1 850343 NFS1 Saccharomyces cerevisiae Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis; required for the post-transcriptional thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria NP_009912.2 92777 R 4932 CDS NP_009913.2 10383774 850344 complement(94621..95763) 1 NC_001135.4 Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance; Dcc1p 95763 DCC1 850344 DCC1 Saccharomyces cerevisiae Dcc1p NP_009913.2 94621 R 4932 CDS NP_009914.2 10383775 850345 96281..101191 1 NC_001135.4 Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding; Bud3p 101191 BUD3 850345 BUD3 Saccharomyces cerevisiae Bud3p NP_009914.2 96281 D 4932 CDS NP_976246.1 42759851 2746859 complement(join(101317..101633,101701..101788)) 1 NC_001135.4 Ycl012cp; Putative protein of unknown function; orthologs are present in S. bayanus, S. paradoxus and Ashbya gossypii; YCL012C is not an essential gene 101788 2746859 YCL012C Saccharomyces cerevisiae Putative protein of unknown function; orthologs are present in S. bayanus, S. paradoxus and Ashbya gossypii; YCL012C is not an essential gene NP_976246.1 101317 R 4932 CDS NP_009916.1 6319835 850346 complement(102075..103358) 1 NC_001135.4 Poly(A+) RNA-binding protein, involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Hrb1p and Npl3p; also binds single-stranded telomeric repeat sequence in vitro; Gbp2p 103358 GBP2 850346 GBP2 Saccharomyces cerevisiae Gbp2p NP_009916.1 102075 R 4932 CDS NP_009917.1 6319836 850347 complement(103571..104350) 1 NC_001135.4 Sgf29p; SaGa associated Factor 29kDa; Probable 29kKDa Subunit of SAGA histone acetyltransferase complex 104350 SGF29 850347 SGF29 Saccharomyces cerevisiae SaGa associated Factor 29kDa; Probable 29kKDa Subunit of SAGA histone acetyltransferase complex NP_009917.1 103571 R 4932 CDS NP_009918.1 6319837 850348 complement(104619..105548) 1 NC_001135.4 Regulatory subunit of acetolactate synthase, which catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria; Ilv6p 105548 ILV6 850348 ILV6 Saccharomyces cerevisiae Ilv6p NP_009918.1 104619 R 4932 CDS NP_009919.3 42759852 850349 complement(105696..106853) 1 NC_001135.4 Stp22p; Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype 106853 STP22 850349 STP22 Saccharomyces cerevisiae Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype NP_009919.3 105696 R 4932 CDS NP_958835.1 41629681 2732686 join(107023..107033,107111..107191,107288..107417) 1 NC_001135.4 Vma9p; Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis 107417 VMA9 2732686 VMA9 Saccharomyces cerevisiae Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis NP_958835.1 107023 D 4932 CDS NP_009922.2 10383777 850351 108021..108791 1 NC_001135.4 Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria; Ldb16p 108791 LDB16 850351 LDB16 Saccharomyces cerevisiae Ldb16p NP_009922.2 108021 D 4932 CDS NP_009923.2 10383778 850352 109105..110670 1 NC_001135.4 Phosphatidylglycerolphosphate synthase, catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis; Pgs1p 110670 PGS1 850352 PGS1 Saccharomyces cerevisiae Pgs1p NP_009923.2 109105 D 4932 CDS NP_009924.3 37362626 850353 complement(join(110843..111556,111633..111674)) 1 NC_001135.4 Ycl002cp; Putative protein of unknown function; YCL002C is not an essential gene 111674 850353 YCL002C Saccharomyces cerevisiae Putative protein of unknown function; YCL002C is not an essential gene NP_009924.3 110843 R 4932 CDS NP_009925.1 6319844 850354 111914..112480 1 NC_001135.4 Rer1p; Protein involved in retention of membrane proteins, including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER 112480 RER1 850354 RER1 Saccharomyces cerevisiae Protein involved in retention of membrane proteins, including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER NP_009925.1 111914 D 4932 CDS NP_009926.1 6319845 850355 113078..113539 1 NC_001135.4 Ycl001w-ap; Putative protein of unknown function; YCL001W-A is not an essential gene 113539 850355 YCL001W-A Saccharomyces cerevisiae Putative protein of unknown function; YCL001W-A is not an essential gene NP_009926.1 113078 D 4932 CDS NP_076878.1 13129156 850356 113768..114022 1 NC_001135.4 Ycl001w-bp; Putative protein of unknown function; identified by homology 114022 850356 YCL001W-B Saccharomyces cerevisiae Putative protein of unknown function; identified by homology NP_076878.1 113768 D 4932 CDS NP_009928.1 6319847 850358 complement(117378..118346) 1 NC_001135.4 Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM; Cdc10p 118346 CDC10 850358 CDC10 Saccharomyces cerevisiae Cdc10p NP_009928.1 117378 R 4932 CDS NP_009929.1 6319848 850359 118618..119169 1 NC_001135.4 Mrpl32p; Mitochondrial ribosomal protein of the large subunit 119169 MRPL32 850359 MRPL32 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit NP_009929.1 118618 D 4932 CDS NP_009930.1 6319849 850360 complement(119573..120316) 1 NC_001135.4 Ycp4p; Protein of unknown function, has sequence and structural similarity to flavodoxins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 120316 YCP4 850360 YCP4 Saccharomyces cerevisiae Protein of unknown function, has sequence and structural similarity to flavodoxins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_009930.1 119573 R 4932 CDS NP_009931.1 6319850 850361 complement(120944..122326) 1 NC_001135.4 Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors; Cit2p 122326 CIT2 850361 CIT2 Saccharomyces cerevisiae Cit2p NP_009931.1 120944 R 4932 CDS NP_009933.1 6319852 850364 complement(126009..126728) 1 NC_001135.4 Ycr007cp; Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene 126728 850364 YCR007C Saccharomyces cerevisiae Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene NP_009933.1 126009 R 4932 CDS NP_009934.1 6319853 850366 128468..130279 1 NC_001135.4 Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p; Sat4p 130279 SAT4 850366 SAT4 Saccharomyces cerevisiae Sat4p NP_009934.1 128468 D 4932 CDS NP_009935.1 6319854 850367 complement(130743..131540) 1 NC_001135.4 Rvs161p; Amphiphysin-like lipid raft protein; subunit of a complex (Rvs161p-Rvs167p) that regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress 131540 RVS161 850367 RVS161 Saccharomyces cerevisiae Amphiphysin-like lipid raft protein; subunit of a complex (Rvs161p-Rvs167p) that regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress NP_009935.1 130743 R 4932 CDS NP_009936.1 6319855 850368 complement(132271..133122) 1 NC_001135.4 Ady2p; Acetate transporter required for normal sporulation; phosphorylated in mitochondria 133122 ADY2 850368 ADY2 Saccharomyces cerevisiae Acetate transporter required for normal sporulation; phosphorylated in mitochondria NP_009936.1 132271 R 4932 CDS NP_009937.2 10383780 850369 complement(133722..136871) 1 NC_001135.4 Putative ATP-dependent permease of the ABC transporter family of proteins; Adp1p 136871 ADP1 850369 ADP1 Saccharomyces cerevisiae Adp1p NP_009937.2 133722 R 4932 CDS NP_009938.2 10383781 850370 137744..138994 1 NC_001135.4 Pgk1p; 3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis 138994 PGK1 850370 PGK1 Saccharomyces cerevisiae 3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis NP_009938.2 137744 D 4932 CDS NP_009940.2 10383782 850372 complement(139183..140931) 1 NC_001135.4 Pol4p; DNA polymerase IV, undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase beta 140931 POL4 850372 POL4 Saccharomyces cerevisiae DNA polymerase IV, undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase beta NP_009940.2 139183 R 4932 CDS NP_009941.2 10383783 850373 complement(141215..142168) 1 NC_001135.4 Ycr015cp; Putative protein of unknown function; YCR015C is not an essential gene 142168 850373 YCR015C Saccharomyces cerevisiae Putative protein of unknown function; YCR015C is not an essential gene NP_009941.2 141215 R 4932 CDS NP_009942.2 10383784 850375 143632..144504 1 NC_001135.4 Ycr016wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; YCR016W is not an essential gene 144504 850375 YCR016W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; YCR016W is not an essential gene NP_009942.2 143632 D 4932 CDS NP_009943.2 10383785 850376 complement(144771..147632) 1 NC_001135.4 Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion; Cwh43p 147632 CWH43 850376 CWH43 Saccharomyces cerevisiae Cwh43p NP_009943.2 144771 R 4932 CDS NP_009944.2 10383786 850377 complement(148236..148901) 1 NC_001135.4 Srd1p; Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation 148901 SRD1 850377 SRD1 Saccharomyces cerevisiae Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation NP_009944.2 148236 R 4932 CDS NP_009946.1 6319865 850381 152835..153926 1 NC_001135.4 Protein necessary for structural stability of L-A double-stranded RNA-containing particles; Mak32p 153926 MAK32 850381 MAK32 Saccharomyces cerevisiae Mak32p NP_009946.1 152835 D 4932 CDS NP_009947.1 6319866 850382 complement(154010..154657) 1 NC_001135.4 Protein required for respiratory growth and stability of the mitochondrial genome; Pet18p 154657 PET18 850382 PET18 Saccharomyces cerevisiae Pet18p NP_009947.1 154010 R 4932 CDS NP_009948.1 6319867 850383 complement(154828..155094) 1 NC_001135.4 Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family; Mak31p 155094 MAK31 850383 MAK31 Saccharomyces cerevisiae Mak31p NP_009948.1 154828 R 4932 CDS NP_009949.1 6319868 850384 155318..155554 1 NC_001135.4 Htl1p; Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance 155554 HTL1 850384 HTL1 Saccharomyces cerevisiae Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance NP_009949.1 155318 D 4932 CDS NP_009950.1 6319869 850385 complement(156105..157103) 1 NC_001135.4 Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase; Hsp30p 157103 HSP30 850385 HSP30 Saccharomyces cerevisiae Hsp30p NP_009950.1 156105 R 4932 CDS NP_009952.2 10383787 850387 complement(158534..160369) 1 NC_001135.4 Ycr023cp; Putative protein of unknown function; YCR023C is not an essential gene 160369 850387 YCR023C Saccharomyces cerevisiae Putative protein of unknown function; YCR023C is not an essential gene NP_009952.2 158534 R 4932 CDS NP_009953.1 6319872 850388 complement(160740..162218) 1 NC_001135.4 Slm5p; Mitochondrial asparaginyl-tRNA synthetase 162218 SLM5 850388 SLM5 Saccharomyces cerevisiae Mitochondrial asparaginyl-tRNA synthetase NP_009953.1 160740 R 4932 CDS NP_878057.1 33438775 1466398 complement(162595..162861) 1 NC_001135.4 Ycr024c-bp; Putative protein of unknown function; identified by expression profiling and mass spectrometry 162861 1466398 YCR024C-B Saccharomyces cerevisiae Putative protein of unknown function; identified by expression profiling and mass spectrometry NP_878057.1 162595 R 4932 CDS NP_058137.1 7839147 850389 complement(162941..163063) 1 NC_001135.4 Small single-membrane span proteolipid that functions as a regulatory subunit of the plasma membrane H(+)-ATPase Pma1p, forms unique helix and positively charged cytoplasmic domain that is able to specifically segregate phosphatidylserines; Pmp1p 163063 PMP1 850389 PMP1 Saccharomyces cerevisiae Pmp1p NP_058137.1 162941 R 4932 CDS NP_009955.2 10383789 850391 complement(164107..166335) 1 NC_001135.4 Nucleotide pyrophosphatase/phosphodiesterase family member; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; Npp1p 166335 NPP1 850391 NPP1 Saccharomyces cerevisiae Npp1p NP_009955.2 164107 R 4932 CDS NP_009956.2 10383790 850392 complement(167366..167995) 1 NC_001135.4 Rhb1p; Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins 167995 RHB1 850392 RHB1 Saccharomyces cerevisiae Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins NP_009956.2 167366 R 4932 CDS NP_009957.1 6319876 850394 complement(170882..172420) 1 NC_001135.4 Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph; Fen2p 172420 FEN2 850394 FEN2 Saccharomyces cerevisiae Fen2p NP_009957.1 170882 R 4932 CDS NP_009958.2 10383791 850395 complement(join(172946..173111,173195..173436)) 1 NC_001135.4 Single-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication; Rim1p 173436 RIM1 850395 RIM1 Saccharomyces cerevisiae Rim1p NP_009958.2 172946 R 4932 CDS NP_009959.2 10383792 850396 complement(173822..176434) 1 NC_001135.4 Syp1p; Protein with a potential role in actin cytoskeletal organization; overexpression suppresses a pfy1 (profilin) null mutation 176434 SYP1 850396 SYP1 Saccharomyces cerevisiae Protein with a potential role in actin cytoskeletal organization; overexpression suppresses a pfy1 (profilin) null mutation NP_009959.2 173822 R 4932 CDS NP_009960.2 10383793 850397 complement(join(177496..177902,178210..178216)) 1 NC_001135.4 Rps14ap; Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Bp and similar to E. coli S11 and rat S14 ribosomal proteins 178216 RPS14A 850397 RPS14A Saccharomyces cerevisiae Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Bp and similar to E. coli S11 and rat S14 ribosomal proteins NP_009960.2 177496 R 4932 CDS NP_009961.2 10383794 850398 179516..186019 1 NC_001135.4 PProtein homologous to human Chediak-Higashi syndrome and murine Beige proteins, which are implicated in disease syndromes due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting; Bph1p 186019 BPH1 850398 BPH1 Saccharomyces cerevisiae Bph1p NP_009961.2 179516 D 4932 CDS NP_009962.2 10383795 850399 186485..190165 1 NC_001135.4 Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; Snt1p 190165 SNT1 850399 SNT1 Saccharomyces cerevisiae Snt1p NP_009962.2 186485 D 4932 CDS NP_009963.1 6319882 850400 190588..191631 1 NC_001135.4 Fen1p; Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway 191631 FEN1 850400 FEN1 Saccharomyces cerevisiae Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway NP_009963.1 190588 D 4932 CDS NP_009964.2 10383796 850401 complement(191830..193014) 1 NC_001135.4 Rrp43p; Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex with Rrp41p, Rrp42p, Rrp4p and Dis3p; required for efficient maturation of 5.8S, 18S and 25S rRNA 193014 RRP43 850401 RRP43 Saccharomyces cerevisiae Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex with Rrp41p, Rrp42p, Rrp4p and Dis3p; required for efficient maturation of 5.8S, 18S and 25S rRNA NP_009964.2 191830 R 4932 CDS NP_009965.2 10383797 850402 193293..194294 1 NC_001135.4 Rbk1p; Putative ribokinase 194294 RBK1 850402 RBK1 Saccharomyces cerevisiae Putative ribokinase NP_009965.2 193293 D 4932 CDS NP_009966.2 10383798 850403 complement(194410..197181) 1 NC_001135.4 Pho87p; Low-affinity inorganic phosphate (Pi) transporter, involved in activation of PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments 197181 PHO87 850403 PHO87 Saccharomyces cerevisiae Low-affinity inorganic phosphate (Pi) transporter, involved in activation of PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments NP_009966.2 194410 R 4932 CDS NP_009967.2 10383799 850405 complement(197617..199545) 1 NC_001135.4 GTP/GDP exchange factor for Rsr1p (Bud1p) required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types; Bud5p 199545 BUD5 850405 BUD5 Saccharomyces cerevisiae Bud5p NP_009967.2 197617 R 4932 CDS NP_009868.3 63536787 850406 complement(199542..200174) 1 NC_001135.4 Matalpha2p; Homeobox-domain protein that, with Mcm1p, represses a-specific genes in haploids; acts with A1p to repress transcription of haploid-specific genes in diploids; one of two genes encoded by the MATalpha mating type cassette 200174 MATALPHA2 850406 MATALPHA2 Saccharomyces cerevisiae Homeobox-domain protein that, with Mcm1p, represses a-specific genes in haploids; acts with A1p to repress transcription of haploid-specific genes in diploids; one of two genes encoded by the MATalpha mating type cassette NP_009868.3 199542 R 4932 CDS NP_009869.3 63535564 850407 200438..200965 1 NC_001135.4 Transcriptional co-activator involved in regulation of mating-type-specific gene expression; targets the transcription factor Mcm1p to the promoters of alpha-specific genes; one of two genes encoded by the MATalpha mating type cassette; Matalpha1p 200965 MATALPHA1 850407 MATALPHA1 Saccharomyces cerevisiae Matalpha1p NP_009869.3 200438 D 4932 CDS NP_009971.1 6319890 850409 complement(201170..205393) 1 NC_001135.4 Taf2p; TFIID subunit (150 kDa), involved in RNA polymerase II transcription initiation 205393 TAF2 850409 TAF2 Saccharomyces cerevisiae TFIID subunit (150 kDa), involved in RNA polymerase II transcription initiation NP_009971.1 201170 R 4932 CDS NP_009972.1 6319891 850410 complement(206257..206640) 1 NC_001135.4 Ycr043cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene 206640 850410 YCR043C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene NP_009972.1 206257 R 4932 CDS NP_009973.1 6319892 850411 complement(206873..207946) 1 NC_001135.4 Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1; Per1p 207946 PER1 850411 PER1 Saccharomyces cerevisiae Per1p NP_009973.1 206873 R 4932 CDS NP_009974.1 6319893 850412 complement(208131..209606) 1 NC_001135.4 Ycr045cp; Putative protein of unknown function 209606 850412 YCR045C Saccharomyces cerevisiae Putative protein of unknown function NP_009974.1 208131 R 4932 CDS NP_009975.1 6319894 850413 complement(209910..210419) 1 NC_001135.4 Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome; Img1p 210419 IMG1 850413 IMG1 Saccharomyces cerevisiae Img1p NP_009975.1 209910 R 4932 CDS NP_009976.1 6319895 850414 complement(210714..211541) 1 NC_001135.4 Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; Bud23p 211541 BUD23 850414 BUD23 Saccharomyces cerevisiae Bud23p NP_009976.1 210714 R 4932 CDS NP_009978.1 6319896 850415 211925..213757 1 NC_001135.4 Are1p; Acyl-CoA:sterol acyltransferase, isozyme of Are2p; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen 213757 ARE1 850415 ARE1 Saccharomyces cerevisiae Acyl-CoA:sterol acyltransferase, isozyme of Are2p; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen NP_009978.1 211925 D 4932 CDS NP_009979.1 6319898 850417 complement(213460..213768) 1 NC_001135.4 Ycr050cp; Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein 213768 850417 YCR050C Saccharomyces cerevisiae Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein NP_009979.1 213460 R 4932 CDS NP_009980.1 6319899 850418 214067..214735 1 NC_001135.4 Ycr051wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene 214735 850418 YCR051W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene NP_009980.1 214067 D 4932 CDS NP_009981.1 6319900 850419 214990..216441 1 NC_001135.4 Rsc6p; Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p 216441 RSC6 850419 RSC6 Saccharomyces cerevisiae Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p NP_009981.1 214990 D 4932 CDS NP_009982.1 6319901 850420 216693..218237 1 NC_001135.4 Threonine synthase, conserved protein that catalyzes formation of threonine from 0-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway; Thr4p 218237 THR4 850420 THR4 Saccharomyces cerevisiae Thr4p NP_009982.1 216693 D 4932 CDS NP_009983.1 6319902 850421 complement(218372..220063) 1 NC_001135.4 Essential protein of unknown function; upstream region contains a Gcn4p responsive site suggesting a possible role in amino acid biosynthesis; Ctr86p 220063 CTR86 850421 CTR86 Saccharomyces cerevisiae Ctr86p NP_009983.1 218372 R 4932 CDS NP_009984.1 6319903 850422 complement(220453..223224) 1 NC_001135.4 Pwp2p; Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis 223224 PWP2 850422 PWP2 Saccharomyces cerevisiae Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis NP_009984.1 220453 R 4932 CDS NP_009985.1 6319904 850423 complement(223450..224226) 1 NC_001135.4 Yih1p; Protein that inhibits activation of Gcn2p, an eIF2 alpha subunit protein kinase, by competing for Gcn1p binding, thus impacting gene expression in response to starvation; has sequence and functional similarity to the mouse IMPACT gene 224226 YIH1 850423 YIH1 Saccharomyces cerevisiae Protein that inhibits activation of Gcn2p, an eIF2 alpha subunit protein kinase, by competing for Gcn1p binding, thus impacting gene expression in response to starvation; has sequence and functional similarity to the mouse IMPACT gene NP_009985.1 223450 R 4932 CDS NP_009986.1 6319905 850424 224395..224730 1 NC_001135.4 Tah1p; HSP90 cofactor; interacts with Hsp82p, Pih1p, Rvb1 and Rvb2, contains a single TPR domain with at least two TPR motifs 224730 TAH1 850424 TAH1 Saccharomyces cerevisiae HSP90 cofactor; interacts with Hsp82p, Pih1p, Rvb1 and Rvb2, contains a single TPR domain with at least two TPR motifs NP_009986.1 224395 D 4932 CDS NP_009987.2 10383800 850425 225559..227454 1 NC_001135.4 Ycr061wp; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 227454 850425 YCR061W Saccharomyces cerevisiae Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern NP_009987.2 225559 D 4932 CDS NP_009990.1 6319908 850427 228314..228787 1 NC_001135.4 Protein involved in bud-site selection; analysis of integrated high-throughput datasets predicts an involvement in RNA splicing; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; Bud31p 228787 BUD31 850427 BUD31 Saccharomyces cerevisiae Bud31p NP_009990.1 228314 D 4932 CDS NP_009991.2 10383801 850429 229306..231000 1 NC_001135.4 Hcm1p; Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role 231000 HCM1 850429 HCM1 Saccharomyces cerevisiae Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role NP_009991.2 229306 D 4932 CDS NP_009992.1 6319911 850430 231496..232959 1 NC_001135.4 Rad18p; Protein involved in postreplication repair; binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; forms heterodimer with Rad6p; contains RING-finger motif 232959 RAD18 850430 RAD18 Saccharomyces cerevisiae Protein involved in postreplication repair; binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; forms heterodimer with Rad6p; contains RING-finger motif NP_009992.1 231496 D 4932 CDS NP_009993.1 6319912 850431 complement(233121..236318) 1 NC_001135.4 Sed4p; Integral endoplasmic reticulum membrane protein, functions as a positive regulator of Sar1p probably through inhibition of GTPase activation by Sec23p; binds Sec16p, participates in vesicle formation, similar to Sec12p 236318 SED4 850431 SED4 Saccharomyces cerevisiae Integral endoplasmic reticulum membrane protein, functions as a positive regulator of Sar1p probably through inhibition of GTPase activation by Sec23p; binds Sec16p, participates in vesicle formation, similar to Sec12p NP_009993.1 233121 R 4932 CDS NP_009994.2 10383802 850432 237210..238772 1 NC_001135.4 Lipase, required for intravacuolar lysis of autophagic bodies; located in the endoplasmic reticulum membrane and targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway; Atg15p 238772 ATG15 850432 ATG15 Saccharomyces cerevisiae Atg15p NP_009994.2 237210 D 4932 CDS NP_009995.1 6319914 850433 239051..240007 1 NC_001135.4 Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway; Cpr4p 240007 CPR4 850433 CPR4 Saccharomyces cerevisiae Cpr4p NP_009995.1 239051 D 4932 CDS NP_009996.2 10383803 850434 complement(240099..240539) 1 NC_001135.4 Mitochondrial ribosomal protein of the small subunit; Img2p 240539 IMG2 850434 IMG2 Saccharomyces cerevisiae Img2p NP_009996.2 240099 R 4932 CDS NP_009997.2 10383804 850435 complement(240801..242348) 1 NC_001135.4 WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus; Rsa4p 242348 RSA4 850435 RSA4 Saccharomyces cerevisiae Rsa4p NP_009997.2 240801 R 4932 CDS NP_009998.2 10383805 850436 complement(242585..246580) 1 NC_001135.4 Ssk22p; MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; functionally redundant with, and homologous to, Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p 246580 SSK22 850436 SSK22 Saccharomyces cerevisiae MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; functionally redundant with, and homologous to, Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p NP_009998.2 242585 R 4932 CDS NP_009999.2 10383806 850437 246960..247907 1 NC_001135.4 Sol2p; Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol1p, Sol3p, and Sol4p 247907 SOL2 850437 SOL2 Saccharomyces cerevisiae Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol1p, Sol3p, and Sol4p NP_009999.2 246960 D 4932 CDS NP_010000.1 6319919 850438 complement(248030..248812) 1 NC_001135.4 Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains; Ers1p 248812 ERS1 850438 ERS1 Saccharomyces cerevisiae Ers1p NP_010000.1 248030 R 4932 CDS NP_878058.1 33438776 1466399 248972..249199 1 NC_001135.4 Ycr075w-ap; Putative protein of unknown function; identified by homology to Ashbya gossypii 249199 1466399 YCR075W-A Saccharomyces cerevisiae Putative protein of unknown function; identified by homology to Ashbya gossypii NP_878058.1 248972 D 4932 CDS NP_010001.1 6319920 850439 complement(249290..250042) 1 NC_001135.4 Ycr076cp; Putative protein of unknown function; YCR076C is not an essential gene 250042 850439 YCR076C Saccharomyces cerevisiae Putative protein of unknown function; YCR076C is not an essential gene NP_010001.1 249290 R 4932 CDS NP_010002.2 10383807 850440 complement(250235..252625) 1 NC_001135.4 Topoisomerase II-associated deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; functionally linked to Pab1p; Pat1p 252625 PAT1 850440 PAT1 Saccharomyces cerevisiae Pat1p NP_010002.2 250235 R 4932 CDS NP_010003.2 10383808 850441 252842..254170 1 NC_001135.4 Ptc6p; Phosphoprotein phosphatase type 2C similar to mammalian PP1Ks; involved in mitophagy; localized to mitochondrial inner membrane space; null mutant is sensitive to rapamycin 254170 PTC6 850441 PTC6 Saccharomyces cerevisiae Phosphoprotein phosphatase type 2C similar to mammalian PP1Ks; involved in mitophagy; localized to mitochondrial inner membrane space; null mutant is sensitive to rapamycin NP_010003.2 252842 D 4932 CDS NP_010004.1 6319923 850442 254368..258651 1 NC_001135.4 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression; Srb8p 258651 SRB8 850442 SRB8 Saccharomyces cerevisiae Srb8p NP_010004.1 254368 D 4932 CDS NP_010005.1 6319924 850443 258880..259266 1 NC_001135.4 Protein of unknown function, putative transcriptional regulator; proposed to be a Ada Histone acetyltransferase complex component; GFP tagged protein is localized to the cytoplasm and nucleus; Ahc2p 259266 AHC2 850443 AHC2 Saccharomyces cerevisiae Ahc2p NP_010005.1 258880 D 4932 CDS NP_010006.1 6319925 850444 259575..259958 1 NC_001135.4 Trx3p; Mitochondrial thioredoxin, highly conserved oxidoreductase required to maintain the redox homeostasis of the cell, forms the mitochondrial thioredoxin system with Trr2p, redox state is maintained by both Trr2p and Glr1p 259958 TRX3 850444 TRX3 Saccharomyces cerevisiae Mitochondrial thioredoxin, highly conserved oxidoreductase required to maintain the redox homeostasis of the cell, forms the mitochondrial thioredoxin system with Trr2p, redox state is maintained by both Trr2p and Glr1p NP_010006.1 259575 D 4932 CDS NP_010007.1 6319926 850445 complement(260308..262449) 1 NC_001135.4 Tup1p; General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes 262449 TUP1 850445 TUP1 Saccharomyces cerevisiae General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes NP_010007.1 260308 R 4932 CDS NP_010009.1 6319928 850447 263389..263961 1 NC_001135.4 Nucleolar protein that forms a complex with Lrs4p which binds Mam1p at kinetochores during meiosis I to mediate accurate chromosome segregation, may be involved in premeiotic DNA replication; possible role in telomere maintenance; Csm1p 263961 CSM1 850447 CSM1 Saccharomyces cerevisiae Csm1p NP_010009.1 263389 D 4932 CDS NP_010011.1 6319930 850449 complement(264003..264464) 1 NC_001135.4 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene; Lug1p 264464 LUG1 850449 LUG1 Saccharomyces cerevisiae Lug1p NP_010011.1 264003 R 4932 CDS NP_010012.1 6319931 850450 265065..266843 1 NC_001135.4 Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; Abp1p 266843 ABP1 850450 ABP1 Saccharomyces cerevisiae Abp1p NP_010012.1 265065 D 4932 CDS NP_010013.2 10383809 850451 267431..272260 1 NC_001135.4 Fig2p; Cell wall adhesin, expressed specifically during mating; may be involved in maintenance of cell wall integrity during mating 272260 FIG2 850451 FIG2 Saccharomyces cerevisiae Cell wall adhesin, expressed specifically during mating; may be involved in maintenance of cell wall integrity during mating NP_010013.2 267431 D 4932 CDS NP_010014.1 6319933 850452 complement(272312..272860) 1 NC_001135.4 Ycr090cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene 272860 850452 YCR090C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene NP_010014.1 272312 R 4932 CDS NP_010015.2 10383810 850453 274401..276563 1 NC_001135.4 Putative serine/threonine protein kinase, most similar to cyclic nucleotide-dependent protein kinase subfamily and the protein kinase C subfamily; Kin82p 276563 KIN82 850453 KIN82 Saccharomyces cerevisiae Kin82p NP_010015.2 274401 D 4932 CDS NP_010016.2 157285763 850454 complement(276761..279817) 1 NC_001135.4 Msh3p; Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability 279817 MSH3 850454 MSH3 Saccharomyces cerevisiae Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability NP_010016.2 276761 R 4932 CDS NP_010017.2 10383811 850455 280114..286440 1 NC_001135.4 Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor; Cdc39p 286440 CDC39 850455 CDC39 Saccharomyces cerevisiae Cdc39p NP_010017.2 280114 D 4932 CDS NP_010018.1 6319937 850456 286759..287934 1 NC_001135.4 Endosomal protein that regulates cell polarity, controls polarized growth; similar to Ynr048wp and Lem3p; Cdc50p 287934 CDC50 850456 CDC50 Saccharomyces cerevisiae Cdc50p NP_010018.1 286759 D 4932 CDS NP_010019.1 6319938 850457 complement(288167..289255) 1 NC_001135.4 Oca4p; Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts 289255 OCA4 850457 OCA4 Saccharomyces cerevisiae Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts NP_010019.1 288167 R 4932 CDS NP_001018032.1 63535565 3077354 289636..289794 1 NC_001135.4 Ycr095w-ap; Putative protein of unknown function 289794 3077354 YCR095W-A Saccharomyces cerevisiae Putative protein of unknown function NP_001018032.1 289636 D 4932 CDS NP_010020.1 6319939 850458 complement(293176..293535) 1 NC_001135.4 Silenced copy of a2 at HMR; similarity to Alpha2p; required along with a1p for inhibiting expression of the HO endonuclease in a/alpha HO/HO diploid cells with an active mating-type interconversion system; Hmra2p 293535 HMRA2 850458 HMRA2 Saccharomyces cerevisiae Hmra2p NP_010020.1 293176 R 4932 CDS NP_010021.1 6319940 850459 join(293832..293936,293991..294236,294289..294318) 1 NC_001135.4 Silenced copy of a1 at HMR; homeobox corepressor that interacts with Alpha2p to repress haploid-specific gene transcription in diploid cells; Hmra1p 294318 HMRA1 850459 HMRA1 Saccharomyces cerevisiae Hmra1p NP_010021.1 293832 D 4932 CDS NP_010022.1 6319941 850462 complement(297046..298602) 1 NC_001135.4 Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability; Git1p 298602 GIT1 850462 GIT1 Saccharomyces cerevisiae Git1p NP_010022.1 297046 R 4932 CDS NP_010023.1 6319942 850463 complement(300829..301296) 1 NC_001135.4 Ycr099cp; Putative protein of unknown function 301296 850463 YCR099C Saccharomyces cerevisiae Putative protein of unknown function NP_010023.1 300829 R 4932 CDS NP_010024.1 6319943 850464 complement(301268..302218) 1 NC_001135.4 Ycr100cp; Putative protein of unknown function 302218 850464 YCR100C Saccharomyces cerevisiae Putative protein of unknown function NP_010024.1 301268 R 4932 CDS NP_010025.1 6319944 850465 complement(302479..303027) 1 NC_001135.4 Ycr101cp; Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene 303027 850465 YCR101C Saccharomyces cerevisiae Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene NP_010025.1 302479 R 4932 CDS NP_010026.1 6319945 850466 complement(304358..305464) 1 NC_001135.4 Ycr102cp; Putative protein of unknown function; involved in copper metabolism; similar to C.carbonum toxD gene; YCR102C is not an essential gene 305464 850466 YCR102C Saccharomyces cerevisiae Putative protein of unknown function; involved in copper metabolism; similar to C.carbonum toxD gene; YCR102C is not an essential gene NP_010026.1 304358 R 4932 CDS NP_010029.1 6319948 850468 307798..308172 1 NC_001135.4 Pau3p; Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme 308172 PAU3 850468 PAU3 Saccharomyces cerevisiae Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme NP_010029.1 307798 D 4932 CDS NP_010030.1 6319949 850469 309067..310152 1 NC_001135.4 NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance; Adh7p 310152 ADH7 850469 ADH7 Saccharomyces cerevisiae Adh7p NP_010030.1 309067 D 4932 CDS NP_010031.1 6319950 850470 310955..313453 1 NC_001135.4 Zinc cluster transcription factor involved in conferring resistance to cycloheximide; Rds1p 313453 RDS1 850470 RDS1 Saccharomyces cerevisiae Rds1p NP_010031.1 310955 D 4932 CDS NP_010032.1 6319951 850471 313887..314978 1 NC_001135.4 Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; Aad3p 314978 AAD3 850471 AAD3 Saccharomyces cerevisiae Aad3p NP_010032.1 313887 D 4932 CDS NP_878059.1 33438777 1466400 complement(315994..316185) 1 NC_001135.4 Ycr108cp; Putative protein of unknown function; identified by fungal homology and RT-PCR 316185 1466400 YCR108C Saccharomyces cerevisiae Putative protein of unknown function; identified by fungal homology and RT-PCR NP_878059.1 315994 R 4932 CDS NP_010033.1 6319953 851348 1802..2953 1 NC_001136.8 Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Cos7p 2953 COS7 851348 COS7 Saccharomyces cerevisiae Cos7p NP_010033.1 1802 D 4932 CDS NP_010034.1 6319954 851350 5985..7814 1 NC_001136.8 Mph2p; Alpha-glucoside permease, transports maltose, maltotriose, alpha-methylglucoside, and turanose; identical to Mph3p; encoded in a subtelomeric position in a region likely to have undergone duplication 7814 MPH2 851350 MPH2 Saccharomyces cerevisiae Alpha-glucoside permease, transports maltose, maltotriose, alpha-methylglucoside, and turanose; identical to Mph3p; encoded in a subtelomeric position in a region likely to have undergone duplication NP_010034.1 5985 D 4932 CDS NP_010035.1 6319955 851351 complement(8683..9756) 1 NC_001136.8 Sor2p; Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in fructose or mannose metabolism 9756 SOR2 851351 SOR2 Saccharomyces cerevisiae Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in fructose or mannose metabolism NP_010035.1 8683 R 4932 CDS NP_010036.1 6319956 851352 complement(11657..13360) 1 NC_001136.8 Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose; Hxt15p 13360 HXT15 851352 HXT15 Saccharomyces cerevisiae Hxt15p NP_010036.1 11657 R 4932 CDS NP_010037.1 6319957 851353 16204..17226 1 NC_001136.8 Thi13p; Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13 17226 THI13 851353 THI13 Saccharomyces cerevisiae Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13 NP_010037.1 16204 D 4932 CDS NP_010038.1 6319958 851354 complement(17577..18566) 1 NC_001136.8 Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase, involved in the oxidative stress response; Aad4p 18566 AAD4 851354 AAD4 Saccharomyces cerevisiae Aad4p NP_010038.1 17577 R 4932 CDS NP_010040.1 6319960 851356 20635..21006 1 NC_001136.8 Ydl241wp; Putative protein of unknown function; YDL241W is not an essential gene 21006 851356 YDL241W Saccharomyces cerevisiae Putative protein of unknown function; YDL241W is not an essential gene NP_010040.1 20635 D 4932 CDS NP_010041.1 6319961 851358 22823..25876 1 NC_001136.8 Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis; Lrg1p 25876 LRG1 851358 LRG1 Saccharomyces cerevisiae Lrg1p NP_010041.1 22823 D 4932 CDS NP_010042.1 6319962 851359 complement(26403..28775) 1 NC_001136.8 Protein required for spore wall formation, thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p; Ady3p 28775 ADY3 851359 ADY3 Saccharomyces cerevisiae Ady3p NP_010042.1 26403 R 4932 CDS NP_010043.1 6319963 851360 complement(28985..30454) 1 NC_001136.8 Gud1p; Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures 30454 GUD1 851360 GUD1 Saccharomyces cerevisiae Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures NP_010043.1 28985 R 4932 CDS NP_010044.1 6319964 851361 30657..31829 1 NC_001136.8 Putative protein of unknown function; YDL237W is not an essential gene; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media; Lrc1p 31829 LRC1 851361 LRC1 Saccharomyces cerevisiae Lrc1p NP_010044.1 30657 D 4932 CDS NP_010045.1 6319965 851362 32296..33234 1 NC_001136.8 Pho13p; Alkaline phosphatase specific for p-nitrophenyl phosphate, involved in dephosphorylation of histone II-A and casein 33234 PHO13 851362 PHO13 Saccharomyces cerevisiae Alkaline phosphatase specific for p-nitrophenyl phosphate, involved in dephosphorylation of histone II-A and casein NP_010045.1 32296 D 4932 CDS NP_010046.1 6319966 851363 complement(33415..33918) 1 NC_001136.8 Ypd1p; Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus 33918 YPD1 851363 YPD1 Saccharomyces cerevisiae Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus NP_010046.1 33415 R 4932 CDS NP_010047.1 6319967 851364 complement(34238..36478) 1 NC_001136.8 Gyp7p; GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking 36478 GYP7 851364 GYP7 Saccharomyces cerevisiae GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking NP_010047.1 34238 R 4932 CDS NP_010048.1 6319968 851365 36798..38174 1 NC_001136.8 Ydl233wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL233W is not an essential gene 38174 851365 YDL233W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL233W is not an essential gene NP_010048.1 36798 D 4932 CDS NP_010049.1 6319969 851366 38488..38598 1 NC_001136.8 Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes protein asparagine-linked glycosylation; type I membrane protein required for incorporation of Ost3p or Ost6p into the OST complex; Ost4p 38598 OST4 851366 OST4 Saccharomyces cerevisiae Ost4p NP_010049.1 38488 D 4932 CDS NP_010050.1 6319970 851367 complement(38868..42245) 1 NC_001136.8 Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport; Bre4p 42245 BRE4 851367 BRE4 Saccharomyces cerevisiae Bre4p NP_010050.1 38868 R 4932 CDS NP_010051.1 6319971 851368 42701..43708 1 NC_001136.8 Ptp1p; Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria 43708 PTP1 851368 PTP1 Saccharomyces cerevisiae Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria NP_010051.1 42701 D 4932 CDS NP_010052.1 6319972 851369 44066..45907 1 NC_001136.8 Ssb1p; Cytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p 45907 SSB1 851369 SSB1 Saccharomyces cerevisiae Cytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p NP_010052.1 44066 D 4932 CDS NP_010054.1 6319974 851371 complement(46272..48032) 1 NC_001136.8 Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p; Hop 48032 HO 851371 HO Saccharomyces cerevisiae Hop NP_010054.1 46272 R 4932 CDS NP_010055.1 6319975 851372 complement(51116..52174) 1 NC_001136.8 Gcs1p; ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p 52174 GCS1 851372 GCS1 Saccharomyces cerevisiae ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p NP_010055.1 51116 R 4932 CDS NP_010056.1 6319976 851373 52446..54101 1 NC_001136.8 Shs1p; One of five related septins (Cdc3p, Cdc10p, Cdc11p, Cdc12p, Shs1p) that form a cortical filamentous collar at the mother-bud neck which is necessary for normal morphogenesis and cytokinesis 54101 SHS1 851373 SHS1 Saccharomyces cerevisiae One of five related septins (Cdc3p, Cdc10p, Cdc11p, Cdc12p, Shs1p) that form a cortical filamentous collar at the mother-bud neck which is necessary for normal morphogenesis and cytokinesis NP_010056.1 52446 D 4932 CDS NP_010057.1 6319977 851302 complement(54398..56347) 1 NC_001136.8 Whi4p; Putative RNA binding protein and partially redundant Whi3p homolog that regulates the cell size requirement for passage through Start and commitment to cell division 56347 WHI4 851302 WHI4 Saccharomyces cerevisiae Putative RNA binding protein and partially redundant Whi3p homolog that regulates the cell size requirement for passage through Start and commitment to cell division NP_010057.1 54398 R 4932 CDS NP_010058.1 6319978 851303 complement(57266..60406) 1 NC_001136.8 Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis; Hbt1p 60406 HBT1 851303 HBT1 Saccharomyces cerevisiae Hbt1p NP_010058.1 57266 R 4932 CDS NP_010059.1 6319979 851304 complement(60873..61802) 1 NC_001136.8 Integral membrane protein localized to mitochondria (untagged protein) and eisosomes, immobile patches at the cortex associated with endocytosis; sporulation and sphingolipid content are altered in mutants; has homologs SUR7 and YNL194C; Fmp45p 61802 FMP45 851304 FMP45 Saccharomyces cerevisiae Fmp45p NP_010059.1 60873 R 4932 CDS NP_010061.1 6319981 851306 complement(62245..65019) 1 NC_001136.8 Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping; Cdc13p 65019 CDC13 851306 CDC13 Saccharomyces cerevisiae Cdc13p NP_010061.1 62245 R 4932 CDS NP_010062.1 6319982 851307 join(65243..65307,65379..65766) 1 NC_001136.8 Dtd1p; D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes 65766 DTD1 851307 DTD1 Saccharomyces cerevisiae D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes NP_010062.1 65243 D 4932 CDS NP_010063.1 6319983 851308 66494..67447 1 NC_001136.8 Ydl218wp; Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions 67447 851308 YDL218W Saccharomyces cerevisiae Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions NP_010063.1 66494 D 4932 CDS NP_010064.1 6319984 851309 complement(67984..68607) 1 NC_001136.8 Tim22p; Component of the mitochondrial Tim54p-Tim22p complex involved in insertion of polytopic proteins into the inner membrane 68607 TIM22 851309 TIM22 Saccharomyces cerevisiae Component of the mitochondrial Tim54p-Tim22p complex involved in insertion of polytopic proteins into the inner membrane NP_010064.1 67984 R 4932 CDS NP_010065.2 93117369 851310 complement(68998..70320) 1 NC_001136.8 Rri1p; Catalytic subunit of the COP9 signalosome (CSN) complex that acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling 70320 RRI1 851310 RRI1 Saccharomyces cerevisiae Catalytic subunit of the COP9 signalosome (CSN) complex that acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling NP_010065.2 68998 R 4932 CDS NP_010066.1 6319986 851311 complement(70641..73919) 1 NC_001136.8 NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels; Gdh2p 73919 GDH2 851311 GDH2 Saccharomyces cerevisiae Gdh2p NP_010066.1 70641 R 4932 CDS NP_010067.1 6319987 851312 complement(74447..76546) 1 NC_001136.8 Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; Prr2p 76546 PRR2 851312 PRR2 Saccharomyces cerevisiae Prr2p NP_010067.1 74447 R 4932 CDS NP_010068.1 6319988 851313 complement(77290..77967) 1 NC_001136.8 Putative RNA-binding protein implicated in ribosome biogenesis; contains an RNA recognition motif (RRM) and has similarity to hydrophilins; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes; Nop6p 77967 NOP6 851313 NOP6 Saccharomyces cerevisiae Nop6p NP_010068.1 77290 R 4932 CDS NP_010069.1 6319989 851314 78427..79059 1 NC_001136.8 Shr3p; Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface 79059 SHR3 851314 SHR3 Saccharomyces cerevisiae Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface NP_010069.1 78427 D 4932 CDS NP_010070.1 6319990 851315 complement(79295..80413) 1 NC_001136.8 Ydl211cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole 80413 851315 YDL211C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole NP_010070.1 79295 R 4932 CDS NP_010071.1 6319991 851317 84271..85986 1 NC_001136.8 Uga4p; Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane 85986 UGA4 851317 UGA4 Saccharomyces cerevisiae Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane NP_010071.1 84271 D 4932 CDS NP_010072.1 6319992 851318 complement(86208..87227) 1 NC_001136.8 Protein involved in pre-mRNA splicing, component of a complex containing Cef1p; interacts with Prp19p; contains an RNA recognition motif; has similarity to S. pombe Cwf2p; Cwc2p 87227 CWC2 851318 CWC2 Saccharomyces cerevisiae Cwc2p NP_010072.1 86208 R 4932 CDS NP_010073.2 82795243 851319 87513..87983 1 NC_001136.8 Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing; Nhp2p 87983 NHP2 851319 NHP2 Saccharomyces cerevisiae Nhp2p NP_010073.2 87513 D 4932 CDS NP_010074.1 6319994 851320 88249..89865 1 NC_001136.8 Gle1p; Cytoplasmic nucleoporin required for polyadenylated RNA export but not for protein import; component of Nup82p nuclear pore subcomplex; contains a nuclear export signal 89865 GLE1 851320 GLE1 Saccharomyces cerevisiae Cytoplasmic nucleoporin required for polyadenylated RNA export but not for protein import; component of Nup82p nuclear pore subcomplex; contains a nuclear export signal NP_010074.1 88249 D 4932 CDS NP_010075.1 6319995 851321 90177..92465 1 NC_001136.8 Ydl206wp; Putative protein of unknown function; YDL206W is not an essential protein 92465 851321 YDL206W Saccharomyces cerevisiae Putative protein of unknown function; YDL206W is not an essential protein NP_010075.1 90177 D 4932 CDS NP_010076.1 6319996 851322 complement(92763..93746) 1 NC_001136.8 Phorphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p; Hem3p 93746 HEM3 851322 HEM3 Saccharomyces cerevisiae Hem3p NP_010076.1 92763 R 4932 CDS NP_010077.1 6319997 851323 94606..95787 1 NC_001136.8 Rtn2p; Protein of unknown function; has similarity to mammalian reticulon proteins; member of the RTNLA (reticulon-like A) subfamily 95787 RTN2 851323 RTN2 Saccharomyces cerevisiae Protein of unknown function; has similarity to mammalian reticulon proteins; member of the RTNLA (reticulon-like A) subfamily NP_010077.1 94606 D 4932 CDS NP_010078.1 6319998 851324 complement(96083..97954) 1 NC_001136.8 Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria; Ack1p 97954 ACK1 851324 ACK1 Saccharomyces cerevisiae Ack1p NP_010078.1 96083 R 4932 CDS NP_010079.1 6319999 851325 98476..99225 1 NC_001136.8 Mrpl11p; Mitochondrial ribosomal protein of the large subunit 99225 MRPL11 851325 MRPL11 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit NP_010079.1 98476 D 4932 CDS NP_010080.1 6320000 851326 99562..100422 1 NC_001136.8 Trm8p; Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA 100422 TRM8 851326 TRM8 Saccharomyces cerevisiae Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA NP_010080.1 99562 D 4932 CDS NP_010081.2 93117370 851327 complement(100502..101068) 1 NC_001136.8 Mgt1p; DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damage 101068 MGT1 851327 MGT1 Saccharomyces cerevisiae DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damage NP_010081.2 100502 R 4932 CDS NP_010082.1 6320002 851328 complement(101291..103354) 1 NC_001136.8 Ydl199cp; Putative transporter, member of the sugar porter family 103354 851328 YDL199C Saccharomyces cerevisiae Putative transporter, member of the sugar porter family NP_010082.1 101291 R 4932 CDS NP_010083.1 6320003 851329 complement(103650..104552) 1 NC_001136.8 Mitochondrial GTP/GDP transporter, essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family; Ggc1p 104552 GGC1 851329 GGC1 Saccharomyces cerevisiae Ggc1p NP_010083.1 103650 R 4932 CDS NP_010084.1 6320004 851330 complement(104918..106495) 1 NC_001136.8 Asf2p; Anti-silencing protein that causes derepression of silent loci when overexpressed 106495 ASF2 851330 ASF2 Saccharomyces cerevisiae Anti-silencing protein that causes derepression of silent loci when overexpressed NP_010084.1 104918 R 4932 CDS NP_010086.1 6320006 851332 107209..111030 1 NC_001136.8 Sec31p; Essential phosphoprotein component (p150) of the COPII coat of secretory pathway vesicles, in complex with Sec13p; required for ER-derived transport vesicle formation 111030 SEC31 851332 SEC31 Saccharomyces cerevisiae Essential phosphoprotein component (p150) of the COPII coat of secretory pathway vesicles, in complex with Sec13p; required for ER-derived transport vesicle formation NP_010086.1 107209 D 4932 CDS NP_010087.1 6320007 851333 111581..114235 1 NC_001136.8 Snf3p; Plasma membrane glucose sensor that regulates glucose transport; has 12 predicted transmembrane segments; long cytoplasmic C-terminal tail is required for low glucose induction of hexose transporter genes HXT2 and HXT4 114235 SNF3 851333 SNF3 Saccharomyces cerevisiae Plasma membrane glucose sensor that regulates glucose transport; has 12 predicted transmembrane segments; long cytoplasmic C-terminal tail is required for low glucose induction of hexose transporter genes HXT2 and HXT4 NP_010087.1 111581 D 4932 CDS NP_010088.1 6320008 851334 114673..115800 1 NC_001136.8 Prenyltransferase, required for cell viability; involved in protein trafficking; Nus1p 115800 NUS1 851334 NUS1 Saccharomyces cerevisiae Nus1p NP_010088.1 114673 D 4932 CDS NP_010089.1 6320009 851335 116322..116867 1 NC_001136.8 Arf1p; ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; functionally interchangeable with Arf2p 116867 ARF1 851335 ARF1 Saccharomyces cerevisiae ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; functionally interchangeable with Arf2p NP_010089.1 116322 D 4932 CDS NP_010090.1 6320010 851336 join(117665..117667,118159..118518) 1 NC_001136.8 Rpl35ap; Protein component of the large (60S) ribosomal subunit, identical to Rpl35Bp and has similarity to rat L35 ribosomal protein 118518 RPL35A 851336 RPL35A Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, identical to Rpl35Bp and has similarity to rat L35 ribosomal protein NP_010090.1 117665 D 4932 CDS NP_010091.1 6320011 851337 complement(118708..121593) 1 NC_001136.8 Ufd2p; Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3 121593 UFD2 851337 UFD2 Saccharomyces cerevisiae Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3 NP_010091.1 118708 R 4932 CDS NP_010092.2 9755328 851338 122217..123590 1 NC_001136.8 Rbs1p; Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain 123590 RBS1 851338 RBS1 Saccharomyces cerevisiae Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain NP_010092.2 122217 D 4932 CDS NP_010093.1 6320013 851339 complement(123866..124999) 1 NC_001136.8 Pph22p; Catalytic subunit of protein phosphatase 2A, functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis 124999 PPH22 851339 PPH22 Saccharomyces cerevisiae Catalytic subunit of protein phosphatase 2A, functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis NP_010093.1 123866 R 4932 CDS NP_010095.1 6320014 851340 125617..126450 1 NC_001136.8 Ydl186wp; Putative protein of unknown function; YDL186W is not an essential gene 126450 851340 YDL186W Saccharomyces cerevisiae Putative protein of unknown function; YDL186W is not an essential gene NP_010095.1 125617 D 4932 CDS NP_010096.1 6320016 851342 126788..130003 1 NC_001136.8 Vacuolar ATPase V1 domain subunit A containing the catalytic nucleotide binding sites; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease; Tfp1p 130003 TFP1 851342 TFP1 Saccharomyces cerevisiae Tfp1p NP_010096.1 126788 D 4932 CDS NP_010097.1 6320017 851344 complement(130408..130485) 1 NC_001136.8 Rpl41ap; Ribosomal protein L47 of the large (60S) ribosomal subunit, identical to Rpl41Bp and has similarity to rat L41 ribosomal protein; comprised of only 25 amino acids; rpl41a rpl41b double null mutant is viable 130485 RPL41A 851344 RPL41A Saccharomyces cerevisiae Ribosomal protein L47 of the large (60S) ribosomal subunit, identical to Rpl41Bp and has similarity to rat L41 ribosomal protein; comprised of only 25 amino acids; rpl41a rpl41b double null mutant is viable NP_010097.1 130408 R 4932 CDS NP_010098.1 6320018 851345 complement(130872..131834) 1 NC_001136.8 Ydl183cp; Putative protein of unknown function; YDL183C is not an essential gene 131834 851345 YDL183C Saccharomyces cerevisiae Putative protein of unknown function; YDL183C is not an essential gene NP_010098.1 130872 R 4932 CDS NP_010099.1 6320019 851346 133438..134724 1 NC_001136.8 Lys20p; Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys21p 134724 LYS20 851346 LYS20 Saccharomyces cerevisiae Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys21p NP_010099.1 133438 D 4932 CDS NP_010100.1 6320020 851347 135180..135437 1 NC_001136.8 Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase, inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has similarity to Stf1p and both Inh1p and Stf1p exhibit the potential to form coiled-coil structures; Inh1p 135437 INH1 851347 INH1 Saccharomyces cerevisiae Inh1p NP_010100.1 135180 D 4932 CDS NP_010101.1 6320021 851374 135897..137540 1 NC_001136.8 Ydl180wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole 137540 851374 YDL180W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole NP_010101.1 135897 D 4932 CDS NP_010102.1 6320022 851375 138292..139206 1 NC_001136.8 Pcl9p; Cyclin, forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p 139206 PCL9 851375 PCL9 Saccharomyces cerevisiae Cyclin, forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p NP_010102.1 138292 D 4932 CDS NP_010103.1 6320023 851376 139523..141115 1 NC_001136.8 Dld2p; D-lactate dehydrogenase, located in the mitochondrial matrix 141115 DLD2 851376 DLD2 Saccharomyces cerevisiae D-lactate dehydrogenase, located in the mitochondrial matrix NP_010103.1 139523 D 4932 CDS NP_010104.1 6320024 851377 complement(141210..141722) 1 NC_001136.8 Ydl177cp; Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene 141722 851377 YDL177C Saccharomyces cerevisiae Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene NP_010104.1 141210 R 4932 CDS NP_010105.1 6320025 851378 142098..144224 1 NC_001136.8 Ydl176wp; Putative protein of unknown function; YDL176W is not an essential gene 144224 851378 YDL176W Saccharomyces cerevisiae Putative protein of unknown function; YDL176W is not an essential gene NP_010105.1 142098 D 4932 CDS NP_010106.1 6320026 851379 complement(144485..145519) 1 NC_001136.8 RING finger protein that interacts with the arginine methyltransferase Hmt1p; may regulate methylation of Npl3p, which modulates Npl3p function in mRNA processing and export; has similarity to Air1p; Air2p 145519 AIR2 851379 AIR2 Saccharomyces cerevisiae Air2p NP_010106.1 144485 R 4932 CDS NP_010107.1 6320027 851380 complement(145827..147590) 1 NC_001136.8 Dld1p; D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane 147590 DLD1 851380 DLD1 Saccharomyces cerevisiae D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane NP_010107.1 145827 R 4932 CDS NP_010108.1 6320028 851381 148192..149079 1 NC_001136.8 Ydl173wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDL173W is not an essential gene 149079 851381 YDL173W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDL173W is not an essential gene NP_010108.1 148192 D 4932 CDS NP_010110.1 6320030 851383 complement(149204..155641) 1 NC_001136.8 NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source; Glt1p 155641 GLT1 851383 GLT1 Saccharomyces cerevisiae Glt1p NP_010110.1 149204 R 4932 CDS NP_010111.1 6320031 851384 156319..157905 1 NC_001136.8 Uga3p; Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus 157905 UGA3 851384 UGA3 Saccharomyces cerevisiae Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus NP_010111.1 156319 D 4932 CDS NP_010112.1 6320032 851385 complement(158065..158736) 1 NC_001136.8 Ugx2p; Protein of unknown function, transcript accumulates in response to any combination of stress conditions 158736 UGX2 851385 UGX2 Saccharomyces cerevisiae Protein of unknown function, transcript accumulates in response to any combination of stress conditions NP_010112.1 158065 R 4932 CDS NP_010113.1 6320033 851386 159605..160765 1 NC_001136.8 Sfa1p; Bifunctional enzyme containing both alcohol dehydrogenase and glutathione-dependent formaldehyde dehydrogenase activities, functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p 160765 SFA1 851386 SFA1 Saccharomyces cerevisiae Bifunctional enzyme containing both alcohol dehydrogenase and glutathione-dependent formaldehyde dehydrogenase activities, functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p NP_010113.1 159605 D 4932 CDS NP_010114.1 6320034 851387 complement(160996..163155) 1 NC_001136.8 Protein of unknown function, rich in asparagine residues; Nrp1p 163155 NRP1 851387 NRP1 Saccharomyces cerevisiae Nrp1p NP_010114.1 160996 R 4932 CDS NP_010115.1 6320035 851388 complement(163450..164043) 1 NC_001136.8 Fap7p; Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D 164043 FAP7 851388 FAP7 Saccharomyces cerevisiae Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D NP_010115.1 163450 R 4932 CDS NP_010116.1 6320036 851389 164291..164866 1 NC_001136.8 Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor; Cdc36p 164866 CDC36 851389 CDC36 Saccharomyces cerevisiae Cdc36p NP_010116.1 164291 D 4932 CDS NP_010117.1 6320038 851391 complement(164988..167255) 1 NC_001136.8 DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination; Cdc9p 167255 CDC9 851391 CDC9 Saccharomyces cerevisiae Cdc9p NP_010117.1 164988 R 4932 CDS NP_010120.1 6320039 851392 167715..169079 1 NC_001136.8 Epsin-like protein involved in endocytosis and actin patch assembly and functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus; Ent1p 169079 ENT1 851392 ENT1 Saccharomyces cerevisiae Ent1p NP_010120.1 167715 D 4932 CDS NP_878060.1 33438778 1466431 complement(169367..169609) 1 NC_001136.8 Ydl160c-ap; Putative protein of unknown function 169609 1466431 YDL160C-A Saccharomyces cerevisiae Putative protein of unknown function NP_878060.1 169367 R 4932 CDS NP_010121.1 6320041 851394 complement(170411..171931) 1 NC_001136.8 Dhh1p; Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping, coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation 171931 DHH1 851394 DHH1 Saccharomyces cerevisiae Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping, coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation NP_010121.1 170411 R 4932 CDS NP_076884.1 13129162 851395 172183..172314 1 NC_001136.8 Ydl159w-ap; Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species 172314 851395 YDL159W-A Saccharomyces cerevisiae Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species NP_076884.1 172183 D 4932 CDS NP_010122.1 6320042 851396 172482..174029 1 NC_001136.8 Ste7p; Signal transducing MAP kinase kinase involved in pheromone response, where it phosphorylates Fus3p, and in the pseudohyphal/invasive growth pathway, through phosphorylation of Kss1p; phosphorylated by Ste11p, degraded by ubiquitin pathway 174029 STE7 851396 STE7 Saccharomyces cerevisiae Signal transducing MAP kinase kinase involved in pheromone response, where it phosphorylates Fus3p, and in the pseudohyphal/invasive growth pathway, through phosphorylation of Kss1p; phosphorylated by Ste11p, degraded by ubiquitin pathway NP_010122.1 172482 D 4932 CDS NP_010124.1 6320044 851398 complement(174233..174589) 1 NC_001136.8 Ydl157cp; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 174589 851398 YDL157C Saccharomyces cerevisiae Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_010124.1 174233 R 4932 CDS NP_010125.1 6320045 851399 174919..176487 1 NC_001136.8 Ydl156wp; Putative protein of unknown function; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus 176487 851399 YDL156W Saccharomyces cerevisiae Putative protein of unknown function; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus NP_010125.1 174919 D 4932 CDS NP_010126.1 6320046 851400 176774..178057 1 NC_001136.8 Clb3p; B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation 178057 CLB3 851400 CLB3 Saccharomyces cerevisiae B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation NP_010126.1 176774 D 4932 CDS NP_010127.1 6320047 851401 178335..181040 1 NC_001136.8 Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans; Msh5p 181040 MSH5 851401 MSH5 Saccharomyces cerevisiae Msh5p NP_010127.1 178335 D 4932 CDS NP_010128.1 6320049 851403 complement(181187..183019) 1 NC_001136.8 Sas10p; Component of the small (ribosomal) subunit (SSU) processosome required for pre-18S rRNa processing; essential nucleolar protein that, when overproduced, disrupts silencing 183019 SAS10 851403 SAS10 Saccharomyces cerevisiae Component of the small (ribosomal) subunit (SSU) processosome required for pre-18S rRNa processing; essential nucleolar protein that, when overproduced, disrupts silencing NP_010128.1 181187 R 4932 CDS NP_010131.1 6320050 851404 183344..184612 1 NC_001136.8 Rpc53p; RNA polymerase III subunit C53 184612 RPC53 851404 RPC53 Saccharomyces cerevisiae RNA polymerase III subunit C53 NP_010131.1 183344 D 4932 CDS NP_010132.1 6320052 851406 184926..187919 1 NC_001136.8 Transmembrane protein involved in formation of Cvt and autophagic vesicles; cycles between the pre-autophagosomal structure and other cytosolic punctate structures, not found in autophagosomes; Atg9p 187919 ATG9 851406 ATG9 Saccharomyces cerevisiae Atg9p NP_010132.1 184926 D 4932 CDS NP_010133.1 6320053 851407 complement(188155..190587) 1 NC_001136.8 Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA; Nop14p 190587 NOP14 851407 NOP14 Saccharomyces cerevisiae Nop14p NP_010133.1 188155 R 4932 CDS NP_010134.1 6320054 851408 190925..192262 1 NC_001136.8 Rpn5p; Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p 192262 RPN5 851408 RPN5 Saccharomyces cerevisiae Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p NP_010134.1 190925 D 4932 CDS NP_010135.1 6320055 851409 192751..194226 1 NC_001136.8 Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; null mutant shows a reduced affinity for the alcian blue dye suggesting a decreased net negative charge of the cell surface; Ldb17p 194226 LDB17 851409 LDB17 Saccharomyces cerevisiae Ldb17p NP_010135.1 192751 D 4932 CDS NP_010136.1 6320056 851410 complement(194572..198177) 1 NC_001136.8 Cop1p; Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway 198177 COP1 851410 COP1 Saccharomyces cerevisiae Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway NP_010136.1 194572 R 4932 CDS NP_010137.2 37362628 851411 complement(198663..199733) 1 NC_001136.8 Ydl144cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL144C is not an essential gene. 199733 851411 YDL144C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL144C is not an essential gene. NP_010137.2 198663 R 4932 CDS NP_010138.1 6320058 851412 199997..201583 1 NC_001136.8 Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; Cct4p 201583 CCT4 851412 CCT4 Saccharomyces cerevisiae Cct4p NP_010138.1 199997 D 4932 CDS NP_010139.1 6320059 851413 complement(201720..202571) 1 NC_001136.8 Crd1p; Cardiolipin synthase; produces cardiolipin, which is an important constituent of mitochondrial membranes; required for normal mitochondrial membrane potential and function 202571 CRD1 851413 CRD1 Saccharomyces cerevisiae Cardiolipin synthase; produces cardiolipin, which is an important constituent of mitochondrial membranes; required for normal mitochondrial membrane potential and function NP_010139.1 201720 R 4932 CDS NP_010140.1 6320060 851414 203040..205112 1 NC_001136.8 Bpl1p; Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation 205112 BPL1 851414 BPL1 Saccharomyces cerevisiae Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation NP_010140.1 203040 D 4932 CDS NP_010141.1 6320061 851415 complement(205361..210562) 1 NC_001136.8 Rpo21p; RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime 210562 RPO21 851415 RPO21 Saccharomyces cerevisiae RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime NP_010141.1 205361 R 4932 CDS NP_010142.2 37362629 851416 complement(211376..212047) 1 NC_001136.8 Scm3p; Nonhistone component of centromeric chromatin that binds stoichiometrically to CenH3-H4 histones, required for kinetochore assembly; contains nuclear export signal (NES); required for G2/M progression and localization of Cse4p 212047 SCM3 851416 SCM3 Saccharomyces cerevisiae Nonhistone component of centromeric chromatin that binds stoichiometrically to CenH3-H4 histones, required for kinetochore assembly; contains nuclear export signal (NES); required for G2/M progression and localization of Cse4p NP_010142.2 211376 R 4932 CDS NP_010143.1 6320063 851417 213352..215643 1 NC_001136.8 Rgt2p; Plasma membrane glucose receptor, highly similar to Snf3p; both Rgt2p and Snf3p serve as transmembrane glucose sensors generating an intracellular signal that induces expression of glucose transporter (HXT) genes 215643 RGT2 851417 RGT2 Saccharomyces cerevisiae Plasma membrane glucose receptor, highly similar to Snf3p; both Rgt2p and Snf3p serve as transmembrane glucose sensors generating an intracellular signal that induces expression of glucose transporter (HXT) genes NP_010143.1 213352 D 4932 CDS NP_010144.1 6320064 851418 216529..217074 1 NC_001136.8 Arf2p; ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; functionally interchangeable with Arf1p 217074 ARF2 851418 ARF2 Saccharomyces cerevisiae ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; functionally interchangeable with Arf1p NP_010144.1 216529 D 4932 CDS NP_010145.1 6320065 851419 join(217600..217602,218008..218367) 1 NC_001136.8 Rpl35bp; Protein component of the large (60S) ribosomal subunit, identical to Rpl35Ap and has similarity to rat L35 ribosomal protein 218367 RPL35B 851419 RPL35B Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, identical to Rpl35Ap and has similarity to rat L35 ribosomal protein NP_010145.1 217600 D 4932 CDS NP_010146.1 6320066 851420 complement(218680..219288) 1 NC_001136.8 Rho GDP dissociation inhibitor involved in the localization and regulation of Cdc42p; Rdi1p 219288 RDI1 851420 RDI1 Saccharomyces cerevisiae Rdi1p NP_010146.1 218680 R 4932 CDS NP_010147.1 6320067 851421 complement(219662..220771) 1 NC_001136.8 Pph21p; Catalytic subunit of protein phosphatase 2A, functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis 220771 PPH21 851421 PPH21 Saccharomyces cerevisiae Catalytic subunit of protein phosphatase 2A, functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis NP_010147.1 219662 R 4932 CDS NP_010148.1 6320068 851422 complement(221724..221801) 1 NC_001136.8 Rpl41bp; Ribosomal protein L47 of the large (60S) ribosomal subunit, identical to Rpl41Ap and has similarity to rat L41 ribosomal protein; comprised of only 25 amino acids; rpl41a rpl41b double null mutant is viable 221801 RPL41B 851422 RPL41B Saccharomyces cerevisiae Ribosomal protein L47 of the large (60S) ribosomal subunit, identical to Rpl41Ap and has similarity to rat L41 ribosomal protein; comprised of only 25 amino acids; rpl41a rpl41b double null mutant is viable NP_010148.1 221724 R 4932 CDS NP_010149.1 6320069 851423 222427..223740 1 NC_001136.8 Ydl133wp; Putative protein of unknown function 223740 851423 YDL133W Saccharomyces cerevisiae Putative protein of unknown function NP_010149.1 222427 D 4932 CDS NP_010150.1 6320070 851424 224304..226751 1 NC_001136.8 Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation; Cdc53p 226751 CDC53 851424 CDC53 Saccharomyces cerevisiae Cdc53p NP_010150.1 224304 D 4932 CDS NP_010151.1 6320071 851425 227393..228715 1 NC_001136.8 Lys21p; Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys20p 228715 LYS21 851425 LYS21 Saccharomyces cerevisiae Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys20p NP_010151.1 227393 D 4932 CDS NP_010152.1 6320072 851426 229171..229431 1 NC_001136.8 Stf1p; Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein 229431 STF1 851426 STF1 Saccharomyces cerevisiae Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein NP_010152.1 229171 D 4932 CDS NP_010153.1 6320073 851427 join(229906..230019,230321..230527) 1 NC_001136.8 Rpp1bp; Ribosomal protein P1 beta, component of the ribosomal stalk, which is involved in interaction of translational elongation factors with ribosome; accumulation is regulated by phosphorylation and interaction with the P2 stalk component 230527 RPP1B 851427 RPP1B Saccharomyces cerevisiae Ribosomal protein P1 beta, component of the ribosomal stalk, which is involved in interaction of translational elongation factors with ribosome; accumulation is regulated by phosphorylation and interaction with the P2 stalk component NP_010153.1 229906 D 4932 CDS NP_010154.1 6320074 851428 231024..231899 1 NC_001136.8 Ydl129wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YDL129W is not an essential gene 231899 851428 YDL129W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YDL129W is not an essential gene NP_010154.1 231024 D 4932 CDS NP_010155.1 6320075 851429 232652..233887 1 NC_001136.8 Vcx1p; Vacuolar H+/Ca2+ exchanger involved in control of cytosolic Ca2+ concentration; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter 233887 VCX1 851429 VCX1 Saccharomyces cerevisiae Vacuolar H+/Ca2+ exchanger involved in control of cytosolic Ca2+ concentration; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter NP_010155.1 232652 D 4932 CDS NP_010156.2 42742057 851430 234927..235853 1 NC_001136.8 Pcl2p; G1 cyclin, associates with Pho85p cyclin-dependent kinase (Cdk) to contribute to entry into the mitotic cell cycle, essential for cell morphogenesis; localizes to sites of polarized cell growth 235853 PCL2 851430 PCL2 Saccharomyces cerevisiae G1 cyclin, associates with Pho85p cyclin-dependent kinase (Cdk) to contribute to entry into the mitotic cell cycle, essential for cell morphogenesis; localizes to sites of polarized cell growth NP_010156.2 234927 D 4932 CDS NP_010157.1 6320077 851431 complement(236157..238664) 1 NC_001136.8 Cdc48p; ATPase in ER, nuclear membrane and cytosol with homology to mammalian p97; in a complex with Npl4p and Ufd1p participates in retrotranslocation of ubiquitinated proteins from the ER into the cytosol for degradation by the proteasome 238664 CDC48 851431 CDC48 Saccharomyces cerevisiae ATPase in ER, nuclear membrane and cytosol with homology to mammalian p97; in a complex with Npl4p and Ufd1p participates in retrotranslocation of ubiquitinated proteins from the ER into the cytosol for degradation by the proteasome NP_010157.1 236157 R 4932 CDS NP_010158.1 6320078 851432 complement(join(239019..239398,239510..239606)) 1 NC_001136.8 Hnt1p; Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint 239606 HNT1 851432 HNT1 Saccharomyces cerevisiae Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint NP_010158.1 239019 R 4932 CDS NP_010159.1 6320079 851433 240259..241197 1 NC_001136.8 Ydl124wp; NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family 241197 851433 YDL124W Saccharomyces cerevisiae NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family NP_010159.1 240259 D 4932 CDS NP_010160.1 6320080 851434 241418..241840 1 NC_001136.8 Sna4p; Protein of unknown function, localized to the vacuolar outer membrane 241840 SNA4 851434 SNA4 Saccharomyces cerevisiae Protein of unknown function, localized to the vacuolar outer membrane NP_010160.1 241418 D 4932 CDS NP_010161.1 6320081 851435 242552..244981 1 NC_001136.8 Ubp1p; Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains 244981 UBP1 851435 UBP1 Saccharomyces cerevisiae Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains NP_010161.1 242552 D 4932 CDS NP_010162.1 6320082 851436 complement(245133..245582) 1 NC_001136.8 Ydl121cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic retiuculum; YDL121C is not an essential protein 245582 851436 YDL121C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic retiuculum; YDL121C is not an essential protein NP_010162.1 245133 R 4932 CDS NP_010163.1 6320083 851437 245923..246447 1 NC_001136.8 Yfh1p; Frataxin, regulates mitochondrial iron accumulation; interacts with Isu1p which promotes Fe-S cluster assembly; interacts with electron transport chain components and may influence respiration; human homolog involved in Friedrich's ataxia 246447 YFH1 851437 YFH1 Saccharomyces cerevisiae Frataxin, regulates mitochondrial iron accumulation; interacts with Isu1p which promotes Fe-S cluster assembly; interacts with electron transport chain components and may influence respiration; human homolog involved in Friedrich's ataxia NP_010163.1 245923 D 4932 CDS NP_010164.1 6320085 851439 complement(246689..247612) 1 NC_001136.8 Ydl119cp; Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria 247612 851439 YDL119C Saccharomyces cerevisiae Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria NP_010164.1 246689 R 4932 CDS NP_010165.1 6320084 851438 247302..247682 1 NC_001136.8 Ydl118wp; Non-essential protein of unconfirmed function; mutants are defective in telomere maintenance, and are synthetically sick or lethal with alpha-synuclein 247682 851438 YDL118W Saccharomyces cerevisiae Non-essential protein of unconfirmed function; mutants are defective in telomere maintenance, and are synthetically sick or lethal with alpha-synuclein NP_010165.1 247302 D 4932 CDS NP_010166.1 6320086 851440 248581..251238 1 NC_001136.8 SH3-domain protein located in the mother-bud neck and the cytokinetic actin ring; mutant phenotype and genetic interactions suggest a role in cytokinesis; Cyk3p 251238 CYK3 851440 CYK3 Saccharomyces cerevisiae Cyk3p NP_010166.1 248581 D 4932 CDS NP_010167.1 6320087 851441 251566..253746 1 NC_001136.8 Subunit of the nuclear pore complex (NPC), forms a subcomplex with Nup85p, Nup120p, Nup145p-C, Sec13p, and Seh1p that plays a role in nuclear mRNA export and NPC biogenesis; Nup84p 253746 NUP84 851441 NUP84 Saccharomyces cerevisiae Nup84p NP_010167.1 251566 D 4932 CDS NP_010168.4 154199603 851442 complement(join(253995..254974,255045..255126)) 1 NC_001136.8 Protein of unknown function, deletion causes hypersensitivity to the K1 killer toxin; Iwr1p 255126 IWR1 851442 IWR1 Saccharomyces cerevisiae Iwr1p NP_010168.4 253995 R 4932 CDS NP_010169.1 6320089 851444 255604..256530 1 NC_001136.8 Ydl114wp; Putative protein of unknown function with similarity to acyl-carrier-protein reductases; YDL114W is not an essential gene 256530 851444 YDL114W Saccharomyces cerevisiae Putative protein of unknown function with similarity to acyl-carrier-protein reductases; YDL114W is not an essential gene NP_010169.1 255604 D 4932 CDS NP_010170.1 6320090 851445 complement(256633..258555) 1 NC_001136.8 Protein required for transport of aminopeptidase I (Lap4p) through the cytoplasm-to-vacuole targeting pathway; binds phosphatidylinositol-3-phosphate, involved in localization of membranes to the preautophagosome, potential Cdc28p substrate; Atg20p 258555 ATG20 851445 ATG20 Saccharomyces cerevisiae Atg20p NP_010170.1 256633 R 4932 CDS NP_010171.1 6320091 851446 258915..263225 1 NC_001136.8 Trm3p; 2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs 263225 TRM3 851446 TRM3 Saccharomyces cerevisiae 2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs NP_010171.1 258915 D 4932 CDS NP_010172.1 6320092 851447 complement(263313..264110) 1 NC_001136.8 Rrp42p; Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex with Rrp4p, Rrp41p, Rrp43p and Dis3p 264110 RRP42 851447 RRP42 Saccharomyces cerevisiae Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex with Rrp4p, Rrp41p, Rrp43p and Dis3p NP_010172.1 263313 R 4932 CDS NP_010173.1 6320093 851448 complement(264512..264964) 1 NC_001136.8 Tma17p; Protein of unknown function that associates with ribosomes 264964 TMA17 851448 TMA17 Saccharomyces cerevisiae Protein of unknown function that associates with ribosomes NP_010173.1 264512 R 4932 CDS NP_010174.1 6320094 851449 complement(265258..267201) 1 NC_001136.8 Ydl109cp; Putative lipase; involved in lipid metabolism; YDL109C is not an essential gene 267201 851449 YDL109C Saccharomyces cerevisiae Putative lipase; involved in lipid metabolism; YDL109C is not an essential gene NP_010174.1 265258 R 4932 CDS NP_010175.1 6320095 851450 join(267698..267725,267807..268699) 1 NC_001136.8 Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters; Kin28p 268699 KIN28 851450 KIN28 Saccharomyces cerevisiae Kin28p NP_010175.1 267698 D 4932 CDS NP_010176.1 6320096 851451 268921..269976 1 NC_001136.8 Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; Mss2p 269976 MSS2 851451 MSS2 Saccharomyces cerevisiae Mss2p NP_010176.1 268921 D 4932 CDS NP_010177.1 6320097 851452 complement(270222..271901) 1 NC_001136.8 Pho2p; Homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; binds cooperatively with Pho4p to the PHO5 promoter; phosphorylation of Pho2p facilitates interaction with Pho4p 271901 PHO2 851452 PHO2 Saccharomyces cerevisiae Homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; binds cooperatively with Pho4p to the PHO5 promoter; phosphorylation of Pho2p facilitates interaction with Pho4p NP_010177.1 270222 R 4932 CDS NP_010178.1 6320098 851453 272389..273597 1 NC_001136.8 Nuclear protein that plays a role in the function of the Smc5p-Rhc18p complex; Nse4p 273597 NSE4 851453 NSE4 Saccharomyces cerevisiae Nse4p NP_010178.1 272389 D 4932 CDS NP_010179.1 6320099 851454 complement(273653..274876) 1 NC_001136.8 Qri7p; Putative metalloprotease, similar to O-sialoglycoprotein metallopeptidase from P. haemolytica; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 274876 QRI7 851454 QRI7 Saccharomyces cerevisiae Putative metalloprotease, similar to O-sialoglycoprotein metallopeptidase from P. haemolytica; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_010179.1 273653 R 4932 CDS NP_010180.1 6320100 851455 complement(275148..276581) 1 NC_001136.8 UDP-N-acetylglucosamine pyrophosphorylase, catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesis; Qri1p 276581 QRI1 851455 QRI1 Saccharomyces cerevisiae Qri1p NP_010180.1 275148 R 4932 CDS NP_010181.1 6320101 851456 276872..280165 1 NC_001136.8 Pol3p; Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER) 280165 POL3 851456 POL3 Saccharomyces cerevisiae Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER) NP_010181.1 276872 D 4932 CDS NP_010182.1 6320102 851457 complement(280307..281848) 1 NC_001136.8 Dun1p; Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair 281848 DUN1 851457 DUN1 Saccharomyces cerevisiae Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair NP_010182.1 280307 R 4932 CDS NP_010183.1 6320103 851458 complement(282112..283176) 1 NC_001136.8 Get3p; ATPase, subunit of the GET complex; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion; involved in resistance to heat and metal stress 283176 GET3 851458 GET3 Saccharomyces cerevisiae ATPase, subunit of the GET complex; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion; involved in resistance to heat and metal stress NP_010183.1 282112 R 4932 CDS NP_010184.1 6320104 851459 283419..284444 1 NC_001136.8 Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; Bug1p 284444 BUG1 851459 BUG1 Saccharomyces cerevisiae Bug1p NP_010184.1 283419 D 4932 CDS NP_010185.1 6320105 851460 complement(284581..285165) 1 NC_001136.8 Snu23p; Component of U4/U6.U5 snRNP involved in mRNA splicing via spliceosome 285165 SNU23 851460 SNU23 Saccharomyces cerevisiae Component of U4/U6.U5 snRNP involved in mRNA splicing via spliceosome NP_010185.1 284581 R 4932 CDS NP_010186.1 6320106 851461 complement(285391..286695) 1 NC_001136.8 Rpn6p; Essential, non-ATPase regulatory subunit of the 26S proteasome lid required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion 286695 RPN6 851461 RPN6 Saccharomyces cerevisiae Essential, non-ATPase regulatory subunit of the 26S proteasome lid required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion NP_010186.1 285391 R 4932 CDS NP_010188.1 6320107 851462 287059..289512 1 NC_001136.8 Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt2p, can instead interact with Pmt3p in some conditions; target for new antifungals; Pmt1p 289512 PMT1 851462 PMT1 Saccharomyces cerevisiae Pmt1p NP_010188.1 287059 D 4932 CDS NP_010190.1 6320109 851464 289909..292140 1 NC_001136.8 Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals; Pmt5p 292140 PMT5 851464 PMT5 Saccharomyces cerevisiae Pmt5p NP_010190.1 289909 D 4932 CDS NP_010191.1 6320111 851466 292781..293221 1 NC_001136.8 Srp14p; Signal recognition particle (SRP) subunit, interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14 293221 SRP14 851466 SRP14 Saccharomyces cerevisiae Signal recognition particle (SRP) subunit, interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14 NP_010191.1 292781 D 4932 CDS NP_010192.1 6320112 851467 complement(293392..294759) 1 NC_001136.8 Ubx3p; UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 294759 UBX3 851467 UBX3 Saccharomyces cerevisiae UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern NP_010192.1 293392 R 4932 CDS NP_010193.1 6320113 851468 complement(295034..296329) 1 NC_001136.8 Ram1p; Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit 296329 RAM1 851468 RAM1 Saccharomyces cerevisiae Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit NP_010193.1 295034 R 4932 CDS NP_010194.1 6320114 851469 296820..298274 1 NC_001136.8 Ydl089wp; Protein of unknown function; interacts with meiotic division protein Csm1p; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery, potential Cdc28p substrate 298274 851469 YDL089W Saccharomyces cerevisiae Protein of unknown function; interacts with meiotic division protein Csm1p; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery, potential Cdc28p substrate NP_010194.1 296820 D 4932 CDS NP_010195.1 6320115 851470 complement(298417..300003) 1 NC_001136.8 Nuclear pore complex subunit, part of a subcomplex also containing Nup53p, Nup170p, and Pse1p; Asm4p 300003 ASM4 851470 ASM4 Saccharomyces cerevisiae Asm4p NP_010195.1 298417 R 4932 CDS NP_010196.1 6320116 851471 complement(300214..300999) 1 NC_001136.8 Luc7p; Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5' splice site; contains two zinc finger motifs; N-terminal zinc finger binds pre-mRNA 300999 LUC7 851471 LUC7 Saccharomyces cerevisiae Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5' splice site; contains two zinc finger motifs; N-terminal zinc finger binds pre-mRNA NP_010196.1 300214 R 4932 CDS NP_010197.1 6320117 851472 301413..302234 1 NC_001136.8 Ydl086wp; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene 302234 851472 YDL086W Saccharomyces cerevisiae Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene NP_010197.1 301413 D 4932 CDS NP_075208.1 12621478 851473 complement(302464..302670) 1 NC_001136.8 Ydl085c-ap; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus 302670 851473 YDL085C-A Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus NP_075208.1 302464 R 4932 CDS NP_010198.1 6320118 851474 303211..304848 1 NC_001136.8 Nde2p; Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain 304848 NDE2 851474 NDE2 Saccharomyces cerevisiae Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain NP_010198.1 303211 D 4932 CDS NP_010199.1 6320119 851475 305237..306577 1 NC_001136.8 Sub2p; Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56 306577 SUB2 851475 SUB2 Saccharomyces cerevisiae Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56 NP_010199.1 305237 D 4932 CDS NP_010200.1 6320120 851476 complement(join(306926..307333,307766..307789)) 1 NC_001136.8 Rps16bp; Protein component of the small (40S) ribosomal subunit; identical to Rps16Ap and has similarity to E. coli S9 and rat S16 ribosomal proteins 307789 RPS16B 851476 RPS16B Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit; identical to Rps16Ap and has similarity to E. coli S9 and rat S16 ribosomal proteins NP_010200.1 306926 R 4932 CDS NP_010201.1 6320121 851477 join(308424..308427,308793..309388) 1 NC_001136.8 Rpl13ap; Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Bp; not essential for viability; has similarity to rat L13 ribosomal protein 309388 RPL13A 851477 RPL13A Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Bp; not essential for viability; has similarity to rat L13 ribosomal protein NP_010201.1 308424 D 4932 CDS NP_010202.1 6320122 851478 complement(309802..310122) 1 NC_001136.8 Rpp1ap; Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component 310122 RPP1A 851478 RPP1A Saccharomyces cerevisiae Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component NP_010202.1 309802 R 4932 CDS NP_010203.1 6320123 851479 complement(310642..312471) 1 NC_001136.8 Thi3p; Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis 312471 THI3 851479 THI3 Saccharomyces cerevisiae Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis NP_010203.1 310642 R 4932 CDS NP_010204.1 6320124 851480 complement(join(312951..314044,314337..314748)) 1 NC_001136.8 Mrk1p; Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation 314748 MRK1 851480 MRK1 Saccharomyces cerevisiae Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation NP_010204.1 312951 R 4932 CDS NP_010205.1 6320125 851481 complement(315357..316388) 1 NC_001136.8 Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle; Mdh3p 316388 MDH3 851481 MDH3 Saccharomyces cerevisiae Mdh3p NP_010205.1 315357 R 4932 CDS NP_010206.1 6320126 851482 complement(316971..320120) 1 NC_001136.8 Vam6p; Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p 320120 VAM6 851482 VAM6 Saccharomyces cerevisiae Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p NP_010206.1 316971 R 4932 CDS NP_010207.1 6320127 851483 complement(320668..321552) 1 NC_001136.8 Subunit of the RPD3L complex; involved in histone deacetylation; Rxt3p 321552 RXT3 851483 RXT3 Saccharomyces cerevisiae Rxt3p NP_010207.1 320668 R 4932 CDS NP_010208.1 6320128 851484 join(322226..322282,322704..322988) 1 NC_001136.8 Rpl31ap; Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Bp and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p 322988 RPL31A 851484 RPL31A Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Bp and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p NP_010208.1 322226 D 4932 CDS NP_010209.1 6320129 851485 complement(324047..326149) 1 NC_001136.8 E3 ubiquitin ligase for Rad6p, required for the ubiquitination of histone H2B, recruitment of Rad6p to promoter chromatin and subsequent methylation of histone H3 (on K4 and K79), contains RING finger domain; Bre1p 326149 BRE1 851485 BRE1 Saccharomyces cerevisiae Bre1p NP_010209.1 324047 R 4932 CDS NP_010210.1 6320130 851486 326613..329567 1 NC_001136.8 Ydl073wp; Putative protein of unknown function; YDL073W is not an essential gene 329567 851486 YDL073W Saccharomyces cerevisiae Putative protein of unknown function; YDL073W is not an essential gene NP_010210.1 326613 D 4932 CDS NP_010211.1 6320131 851487 complement(329836..330447) 1 NC_001136.8 Yet3p; Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein 330447 YET3 851487 YET3 Saccharomyces cerevisiae Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein NP_010211.1 329836 R 4932 CDS NP_010213.1 6320132 851488 331025..332941 1 NC_001136.8 Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p; Bdf2p 332941 BDF2 851488 BDF2 Saccharomyces cerevisiae Bdf2p NP_010213.1 331025 D 4932 CDS NP_010214.2 37362630 851491 complement(333121..333810) 1 NC_001136.8 Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader; Cbs1p 333810 CBS1 851491 CBS1 Saccharomyces cerevisiae Cbs1p NP_010214.2 333121 R 4932 CDS NP_010216.1 6320136 851492 complement(334217..334396) 1 NC_001136.8 Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; Cox9p 334396 COX9 851492 COX9 Saccharomyces cerevisiae Cox9p NP_010216.1 334217 R 4932 CDS NP_010217.1 6320137 851493 334835..336121 1 NC_001136.8 Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes; Idp1p 336121 IDP1 851493 IDP1 Saccharomyces cerevisiae Idp1p NP_010217.1 334835 D 4932 CDS NP_010218.2 93117371 851494 complement(336249..337277) 1 NC_001136.8 Pex19p; Chaperone and import receptor for newly-synthesized class I peroxisomal membrane proteins (PMPs), binds PMPs in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane 337277 PEX19 851494 PEX19 Saccharomyces cerevisiae Chaperone and import receptor for newly-synthesized class I peroxisomal membrane proteins (PMPs), binds PMPs in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane NP_010218.2 336249 R 4932 CDS NP_010219.1 6320139 851495 join(337487..337524,337635..338070) 1 NC_001136.8 Ubc9p; SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC) 338070 UBC9 851495 UBC9 Saccharomyces cerevisiae SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC) NP_010219.1 337487 D 4932 CDS NP_010220.1 6320141 851497 complement(338272..340134) 1 NC_001136.8 Ydl063cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL063C is not an essential gene 340134 851497 YDL063C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL063C is not an essential gene NP_010220.1 338272 R 4932 CDS NP_010222.1 6320142 851498 complement(340628..340798) 1 NC_001136.8 Rps29bp; Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Ap and has similarity to rat S29 and E. coli S14 ribosomal proteins 340798 RPS29B 851498 RPS29B Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Ap and has similarity to rat S29 and E. coli S14 ribosomal proteins NP_010222.1 340628 R 4932 CDS NP_010223.1 6320143 851499 341619..343985 1 NC_001136.8 Tsr1p; Protein required for processing of 20S pre-rRNA in the cytoplasm, associates with pre-40S ribosomal particles 343985 TSR1 851499 TSR1 Saccharomyces cerevisiae Protein required for processing of 20S pre-rRNA in the cytoplasm, associates with pre-40S ribosomal particles NP_010223.1 341619 D 4932 CDS NP_010224.1 6320144 851500 complement(344237..344953) 1 NC_001136.8 Rad59p; Protein involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; homologous to Rad52p 344953 RAD59 851500 RAD59 Saccharomyces cerevisiae Protein involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; homologous to Rad52p NP_010224.1 344237 R 4932 CDS NP_010225.1 6320145 851501 345665..351037 1 NC_001136.8 Uso1p; Essential protein involved in intracellular protein transport, coiled-coil protein necessary for transport from ER to Golgi; required for assembly of the ER-to-Golgi SNARE complex 351037 USO1 851501 USO1 Saccharomyces cerevisiae Essential protein involved in intracellular protein transport, coiled-coil protein necessary for transport from ER to Golgi; required for assembly of the ER-to-Golgi SNARE complex NP_010225.1 345665 D 4932 CDS NP_010226.1 6320146 851502 351434..352420 1 NC_001136.8 Ydl057wp; Putative protein of unknown function; YDL057W is not an essential gene 352420 851502 YDL057W Saccharomyces cerevisiae Putative protein of unknown function; YDL057W is not an essential gene NP_010226.1 351434 D 4932 CDS NP_010227.1 6320147 851503 352877..355378 1 NC_001136.8 Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes; Mbp1p 355378 MBP1 851503 MBP1 Saccharomyces cerevisiae Mbp1p NP_010227.1 352877 D 4932 CDS NP_010228.1 6320148 851504 complement(355674..356759) 1 NC_001136.8 Psa1p; GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure 356759 PSA1 851504 PSA1 Saccharomyces cerevisiae GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure NP_010228.1 355674 R 4932 CDS NP_010229.1 6320149 851506 complement(359825..361285) 1 NC_001136.8 Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport; Mch1p 361285 MCH1 851506 MCH1 Saccharomyces cerevisiae Mch1p NP_010229.1 359825 R 4932 CDS NP_010230.1 6320150 851507 complement(361699..362256) 1 NC_001136.8 Pbp4p; Pbp1p binding protein, interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay 362256 PBP4 851507 PBP4 Saccharomyces cerevisiae Pbp1p binding protein, interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay NP_010230.1 361699 R 4932 CDS NP_010231.1 6320151 851508 complement(362672..363583) 1 NC_001136.8 Slc1p; 1-acyl-sn-gylcerol-3-phosphate acyltransferase, catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; located in lipid particles and endoplasmic reticulum 363583 SLC1 851508 SLC1 Saccharomyces cerevisiae 1-acyl-sn-gylcerol-3-phosphate acyltransferase, catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; located in lipid particles and endoplasmic reticulum NP_010231.1 362672 R 4932 CDS NP_010232.1 6320152 851509 363952..364779 1 NC_001136.8 RNA binding protein required for maturation of tRNA and snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen; Lhp1p 364779 LHP1 851509 LHP1 Saccharomyces cerevisiae Lhp1p NP_010232.1 363952 D 4932 CDS NP_010234.1 6320154 851511 complement(365068..365874) 1 NC_001136.8 Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; Knh1p 365874 KNH1 851511 KNH1 Saccharomyces cerevisiae Knh1p NP_010234.1 365068 R 4932 CDS NP_010235.1 6320155 851512 complement(366739..368211) 1 NC_001136.8 Stp4p; Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p 368211 STP4 851512 STP4 Saccharomyces cerevisiae Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p NP_010235.1 366739 R 4932 CDS NP_010236.1 6320156 851513 369769..370704 1 NC_001136.8 Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization; Sit4p 370704 SIT4 851513 SIT4 Saccharomyces cerevisiae Sit4p NP_010236.1 369769 D 4932 CDS NP_010237.1 6320157 851514 371237..371758 1 NC_001136.8 Npc2p; Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes 371758 NPC2 851514 NPC2 Saccharomyces cerevisiae Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes NP_010237.1 371237 D 4932 CDS NP_010238.1 6320158 851515 372245..372532 1 NC_001136.8 Mrp10p; Mitochondrial ribosomal protein of the small subunit 372532 MRP10 851515 MRP10 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the small subunit NP_010238.1 372245 D 4932 CDS NP_010239.1 6320159 851516 complement(372685..373605) 1 NC_001136.8 Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin; Fad1p 373605 FAD1 851516 FAD1 Saccharomyces cerevisiae Fad1p NP_010239.1 372685 R 4932 CDS NP_010240.1 6320160 851517 complement(373964..375286) 1 NC_001136.8 Mtf2p; Mitochondrial matrix protein that interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription 375286 MTF2 851517 MTF2 Saccharomyces cerevisiae Mitochondrial matrix protein that interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription NP_010240.1 373964 R 4932 CDS NP_010241.1 6320161 851518 complement(375677..376477) 1 NC_001136.8 Subunit of the SF3a splicing factor complex, required for spliceosome assembly; Prp11p 376477 PRP11 851518 PRP11 Saccharomyces cerevisiae Prp11p NP_010241.1 375677 R 4932 CDS NP_010242.1 6320163 851520 complement(376754..378442) 1 NC_001136.8 Sir2p; Conserved NAD+ dependent histone deacetylase of the Sirtuin family involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and the rDNA locus; negatively regulates initiation of DNA replication 378442 SIR2 851520 SIR2 Saccharomyces cerevisiae Conserved NAD+ dependent histone deacetylase of the Sirtuin family involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and the rDNA locus; negatively regulates initiation of DNA replication NP_010242.1 376754 R 4932 CDS NP_010244.1 6320164 851521 complement(378871..381435) 1 NC_001136.8 Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing; Nat1p 381435 NAT1 851521 NAT1 Saccharomyces cerevisiae Nat1p NP_010244.1 378871 R 4932 CDS NP_010245.1 6320165 851522 complement(381983..382330) 1 NC_001136.8 Prm7p; Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements 382330 PRM7 851522 PRM7 Saccharomyces cerevisiae Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements NP_010245.1 381983 R 4932 CDS NP_010246.1 6320166 851523 complement(382327..384078) 1 NC_001136.8 Ydl038cp; Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) 384078 851523 YDL038C Saccharomyces cerevisiae Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) NP_010246.1 382327 R 4932 CDS NP_010247.1 6320167 851524 complement(384598..385584) 1 NC_001136.8 Protein of unconfirmed function, similar to cell surface flocculin Muc1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; Bsc1p 385584 BSC1 851524 BSC1 Saccharomyces cerevisiae Bsc1p NP_010247.1 384598 R 4932 CDS NP_010248.1 6320168 851525 complement(387510..388898) 1 NC_001136.8 Pus9p; Mitochondrial tRNA pseudouridine synthase involved in pseudouridylation of mitochondrial tRNAs at position 32 388898 PUS9 851525 PUS9 Saccharomyces cerevisiae Mitochondrial tRNA pseudouridine synthase involved in pseudouridylation of mitochondrial tRNAs at position 32 NP_010248.1 387510 R 4932 CDS NP_010249.1 6320170 851527 complement(389169..392054) 1 NC_001136.8 Plasma membrane G protein coupled receptor (GPCR) that interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis; Gpr1p 392054 GPR1 851527 GPR1 Saccharomyces cerevisiae Gpr1p NP_010249.1 389169 R 4932 CDS NP_010251.1 6320172 851529 complement(392656..393909) 1 NC_001136.8 tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF); Slm3p 393909 SLM3 851529 SLM3 Saccharomyces cerevisiae Slm3p NP_010251.1 392656 R 4932 CDS NP_010253.1 6320173 851530 394214..397201 1 NC_001136.8 Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis; Dbp10p 397201 DBP10 851530 DBP10 Saccharomyces cerevisiae Dbp10p NP_010253.1 394214 D 4932 CDS NP_010254.1 6320174 851531 397534..399126 1 NC_001136.8 Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex; Prp9p 399126 PRP9 851531 PRP9 Saccharomyces cerevisiae Prp9p NP_010254.1 397534 D 4932 CDS NP_010255.1 6320175 851532 join(399337..399358,399482..400635) 1 NC_001136.8 Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity; Arp2p 400635 ARP2 851532 ARP2 Saccharomyces cerevisiae Arp2p NP_010255.1 399337 D 4932 CDS NP_010256.1 6320176 851533 complement(400994..403288) 1 NC_001136.8 Mps1p; Dual-specificity kinase required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, and checkpoint protein Mad1p 403288 MPS1 851533 MPS1 Saccharomyces cerevisiae Dual-specificity kinase required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, and checkpoint protein Mad1p NP_010256.1 400994 R 4932 CDS NP_010257.1 6320178 851535 complement(403692..404954) 1 NC_001136.8 Ydl027cp; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL027C is not an essential gene 404954 851535 YDL027C Saccharomyces cerevisiae Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL027C is not an essential gene NP_010257.1 403692 R 4932 CDS NP_010259.1 6320179 851536 complement(405341..407203) 1 NC_001136.8 Ydl025cp; Putative protein kinase, potentially phosphorylated by Cdc28p; YDL025C is not an essential gene 407203 851536 YDL025C Saccharomyces cerevisiae Putative protein kinase, potentially phosphorylated by Cdc28p; YDL025C is not an essential gene NP_010259.1 405341 R 4932 CDS NP_010260.1 6320180 851537 complement(408448..409854) 1 NC_001136.8 Protein of unknown function, involved in invasive and pseudohyphal growth; Dia3p 409854 DIA3 851537 DIA3 Saccharomyces cerevisiae Dia3p NP_010260.1 408448 R 4932 CDS NP_010262.1 6320181 851539 411822..412997 1 NC_001136.8 NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p; Gpd1p 412997 GPD1 851539 GPD1 Saccharomyces cerevisiae Gpd1p NP_010262.1 411822 D 4932 CDS NP_010263.1 6320183 851541 413950..414885 1 NC_001136.8 Homolog of Gpm1p phosphoglycerate mutase which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event; Gpm2p 414885 GPM2 851541 GPM2 Saccharomyces cerevisiae Gpm2p NP_010263.1 413950 D 4932 CDS NP_010264.1 6320184 851542 complement(415110..416705) 1 NC_001136.8 Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; Rpn4p 416705 RPN4 851542 RPN4 Saccharomyces cerevisiae Rpn4p NP_010264.1 415110 R 4932 CDS NP_010265.1 6320185 851543 complement(417660..421511) 1 NC_001136.8 Osh2p; Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability 421511 OSH2 851543 OSH2 Saccharomyces cerevisiae Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability NP_010265.1 417660 R 4932 CDS NP_010266.1 6320186 851544 complement(422830..423507) 1 NC_001136.8 Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport; Erp3p 423507 ERP3 851544 ERP3 Saccharomyces cerevisiae Erp3p NP_010266.1 422830 R 4932 CDS NP_010267.1 6320187 851545 424206..425729 1 NC_001136.8 DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in mitosis through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression; Cdc7p 425729 CDC7 851545 CDC7 Saccharomyces cerevisiae Cdc7p NP_010267.1 424206 D 4932 CDS NP_010269.1 6320189 851547 complement(425999..426931) 1 NC_001136.8 Tsc13p; Enoyl reductase that catalyzes the last step in each cycle of very long chain fatty acid elongation, localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions, coimmunoprecipitates with elongases Fen1p and Sur4p 426931 TSC13 851547 TSC13 Saccharomyces cerevisiae Enoyl reductase that catalyzes the last step in each cycle of very long chain fatty acid elongation, localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions, coimmunoprecipitates with elongases Fen1p and Sur4p NP_010269.1 425999 R 4932 CDS NP_010270.1 6320190 851548 427361..428344 1 NC_001136.8 Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin; Nop1p 428344 NOP1 851548 NOP1 Saccharomyces cerevisiae Nop1p NP_010270.1 427361 D 4932 CDS NP_010271.1 6320191 851549 429064..430923 1 NC_001136.8 Subunit of the Slx5-Slx8 substrate-specific ubiquitin ligase complex; stimulated by prior attachment of SUMO to the substrate; Slx5p 430923 SLX5 851549 SLX5 Saccharomyces cerevisiae Slx5p NP_010271.1 429064 D 4932 CDS NP_010272.1 6320192 851550 complement(join(431105..431383,431470..431514)) 1 NC_001136.8 Ydl012cp; Plasma membrane protein of unknown function; YDL012C is not an essential gene 431514 851550 YDL012C Saccharomyces cerevisiae Plasma membrane protein of unknown function; YDL012C is not an essential gene NP_010272.1 431105 R 4932 CDS NP_010274.1 6320193 851551 432327..433022 1 NC_001136.8 Monothiol glutaredoxin that binds an iron-sulfur cluster; more similar in activity to dithiol than other monothiol glutaredoxins; forms homodimers; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; Grx6p 433022 GRX6 851551 GRX6 Saccharomyces cerevisiae Grx6p NP_010274.1 432327 D 4932 CDS NP_010276.1 6320196 851554 433494..433991 1 NC_001136.8 Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; Apc11p 433991 APC11 851554 APC11 Saccharomyces cerevisiae Apc11p NP_010276.1 433494 D 4932 CDS NP_001032574.1 82795244 3799969 complement(436564..436821) 1 NC_001136.8 Ydl007c-ap; Putative protein of unknown function 436821 3799969 YDL007C-A Saccharomyces cerevisiae Putative protein of unknown function NP_001032574.1 436564 R 4932 CDS NP_010277.1 6320197 851557 438044..439357 1 NC_001136.8 Rpt2p; One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle 439357 RPT2 851557 RPT2 Saccharomyces cerevisiae One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle NP_010277.1 438044 D 4932 CDS NP_010278.1 6320198 851558 439906..440751 1 NC_001136.8 Type 2C protein phosphatase (PP2C); inactivates the osmosensing MAPK cascade by dephosphorylating Hog1p; mutation delays mitochondrial inheritance; deletion reveals defects in precursor tRNA splicing, sporulation and cell separation; Ptc1p 440751 PTC1 851558 PTC1 Saccharomyces cerevisiae Ptc1p NP_010278.1 439906 D 4932 CDS NP_010279.1 6320199 851559 complement(441011..442306) 1 NC_001136.8 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; Med2p 442306 MED2 851559 MED2 Saccharomyces cerevisiae Med2p NP_010279.1 441011 R 4932 CDS NP_010280.1 6320200 851560 443026..443508 1 NC_001136.8 Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated; Atp16p 443508 ATP16 851560 ATP16 Saccharomyces cerevisiae Atp16p NP_010280.1 443026 D 4932 CDS NP_010281.1 6320201 851561 444680..446380 1 NC_001136.8 Mcd1p; Essential protein required for sister chromatid cohesion in mitosis and meiosis; subunit of the cohesin complex; expression is cell cycle regulated and peaks in S phase 446380 MCD1 851561 MCD1 Saccharomyces cerevisiae Essential protein required for sister chromatid cohesion in mitosis and meiosis; subunit of the cohesin complex; expression is cell cycle regulated and peaks in S phase NP_010281.1 444680 D 4932 CDS NP_010282.1 6320202 851562 complement(446964..447575) 1 NC_001136.8 Protein related to mammalian high mobility group proteins; likely component of the INO80 complex, which is an ATP-dependent chromatin-remodeling complex; Nhp10p 447575 NHP10 851562 NHP10 Saccharomyces cerevisiae Nhp10p NP_010282.1 446964 R 4932 CDS NP_010283.1 6320203 851563 447981..449273 1 NC_001136.8 Rmd1p; Cytoplasmic protein required for sporulation 449273 RMD1 851563 RMD1 Saccharomyces cerevisiae Cytoplasmic protein required for sporulation NP_010283.1 447981 D 4932 CDS NP_010284.1 6320204 851564 complement(450217..452472) 1 NC_001136.8 Nth1p; Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p 452472 NTH1 851564 NTH1 Saccharomyces cerevisiae Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p NP_010284.1 450217 R 4932 CDS NP_010285.1 6320205 851565 453042..453647 1 NC_001136.8 Yrb1p; Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1 453647 YRB1 851565 YRB1 Saccharomyces cerevisiae Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1 NP_010285.1 453042 D 4932 CDS NP_010286.1 6320206 851566 454119..454751 1 NC_001136.8 Vacuolar protein that presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; similar to Rcr1p; Rcr2p 454751 RCR2 851566 RCR2 Saccharomyces cerevisiae Rcr2p NP_010286.1 454119 D 4932 CDS NP_878061.1 33438779 1466432 454779..454901 1 NC_001136.8 Ydr003w-ap; Putative protein of unknown function; identified by expression profiling and mass spectrometry 454901 1466432 YDR003W-A Saccharomyces cerevisiae Putative protein of unknown function; identified by expression profiling and mass spectrometry NP_878061.1 454779 D 4932 CDS NP_010287.1 6320207 851567 455198..456580 1 NC_001136.8 Rad57p; Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p 456580 RAD57 851567 RAD57 Saccharomyces cerevisiae Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p NP_010287.1 455198 D 4932 CDS NP_010288.1 6320208 851568 complement(join(456833..458014,458095..458100)) 1 NC_001136.8 Negative regulator of RNA polymerase III; component of several signaling pathways that repress polymerase III transcription in response to changes in cellular environment; targets the initiation factor TFIIIB; Maf1p 458100 MAF1 851568 MAF1 Saccharomyces cerevisiae Maf1p NP_010288.1 456833 R 4932 CDS NP_010289.1 6320209 851569 complement(458539..461244) 1 NC_001136.8 Sok1p; Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13 461244 SOK1 851569 SOK1 Saccharomyces cerevisiae Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13 NP_010289.1 458539 R 4932 CDS NP_010290.1 6320210 851570 461839..462513 1 NC_001136.8 Trp1p; Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) 462513 TRP1 851570 TRP1 Saccharomyces cerevisiae Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) NP_010290.1 461839 D 4932 CDS NP_010292.1 6320212 851572 463431..464993 1 NC_001136.8 Transcriptional regulator involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity; Gal3p 464993 GAL3 851572 GAL3 Saccharomyces cerevisiae Gal3p NP_010292.1 463431 D 4932 CDS NP_010294.1 6320214 851574 465916..470421 1 NC_001136.8 Snq2p; Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species 470421 SNQ2 851574 SNQ2 Saccharomyces cerevisiae Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species NP_010294.1 465916 D 4932 CDS NP_010295.1 6320215 851575 471850..472938 1 NC_001136.8 Rpl4bp; Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Ap and has similarity to E. coli L4 and rat L4 ribosomal proteins 472938 RPL4B 851575 RPL4B Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Ap and has similarity to E. coli L4 and rat L4 ribosomal proteins NP_010295.1 471850 D 4932 CDS NP_010296.1 6320216 851576 473154..473780 1 NC_001136.8 Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery; Psf1p 473780 PSF1 851576 PSF1 Saccharomyces cerevisiae Psf1p NP_010296.1 473154 D 4932 CDS NP_010297.1 6320217 851577 474043..475986 1 NC_001136.8 Rad61p; Protein of unknown function; mutation confers radiation sensitivity 475986 RAD61 851577 RAD61 Saccharomyces cerevisiae Protein of unknown function; mutation confers radiation sensitivity NP_010297.1 474043 D 4932 CDS NP_001035220.1 93117372 4036073 477794..478282 1 NC_001136.8 Meiosis-specific protein that down-regulates Rad51p-mediated mitotic recombination when the meiotic recombination machinery is impaired; early meiotic gene, transcribed specifically during meiotic prophase; Hed1p 478282 HED1 4036073 HED1 Saccharomyces cerevisiae Hed1p NP_001035220.1 477794 D 4932 CDS NP_010299.1 6320219 851579 complement(478471..478755) 1 NC_001136.8 Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis; Dad1p 478755 DAD1 851579 DAD1 Saccharomyces cerevisiae Dad1p NP_010299.1 478471 R 4932 CDS NP_010300.1 6320220 851580 complement(479112..482264) 1 NC_001136.8 Kcs1p; Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance 482264 KCS1 851580 KCS1 Saccharomyces cerevisiae Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance NP_010300.1 479112 R 4932 CDS NP_010301.1 6320221 851581 complement(482667..483857) 1 NC_001136.8 Ydr018cp; Probable membrane protein with three predicted transmembrane domains; homologous to Ybr042cp, similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; null exhibits no apparent phenotype 483857 851581 YDR018C Saccharomyces cerevisiae Probable membrane protein with three predicted transmembrane domains; homologous to Ybr042cp, similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; null exhibits no apparent phenotype NP_010301.1 482667 R 4932 CDS NP_010302.1 6320222 851582 complement(484160..485362) 1 NC_001136.8 T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm; Gcv1p 485362 GCV1 851582 GCV1 Saccharomyces cerevisiae Gcv1p NP_010302.1 484160 R 4932 CDS NP_010303.1 6320223 851583 complement(485743..486441) 1 NC_001136.8 Predicted protein shares weak similarity with uridine kinases and with phosphoribokinases; null mutant suppresses dst1delta sensitivity for 6-azauracil; Das2p 486441 DAS2 851583 DAS2 Saccharomyces cerevisiae Das2p NP_010303.1 485743 R 4932 CDS NP_010304.1 6320224 851584 486801..488000 1 NC_001136.8 Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases; Fal1p 488000 FAL1 851584 FAL1 Saccharomyces cerevisiae Fal1p NP_010304.1 486801 D 4932 CDS NP_010305.1 6320225 851585 complement(488069..488659) 1 NC_001136.8 Protein required for autophagosome formation in concert with Atg17p; may be involved in microtubule organization; high-copy suppressor of CIK1 deletion; Cis1p 488659 CIS1 851585 CIS1 Saccharomyces cerevisiae Cis1p NP_010305.1 488069 R 4932 CDS NP_010306.1 6320226 851587 489505..490893 1 NC_001136.8 Ses1p; Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p 490893 SES1 851587 SES1 Saccharomyces cerevisiae Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p NP_010306.1 489505 D 4932 CDS NP_010308.1 6320228 851589 join(491512..491556,491896..492321) 1 NC_001136.8 Rps11ap; Protein component of the small (40S) ribosomal subunit; identical to Rps11Bp and has similarity to E. coli S17 and rat S11 ribosomal proteins 492321 RPS11A 851589 RPS11A Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit; identical to Rps11Bp and has similarity to E. coli S17 and rat S11 ribosomal proteins NP_010308.1 491512 D 4932 CDS NP_010309.1 6320229 851590 complement(492553..494265) 1 NC_001136.8 Ydr026cp; Protein of unknown function that may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein that may bind to the Ter region of rDNA; interacts physically with Fob1p 494265 851590 YDR026C Saccharomyces cerevisiae Protein of unknown function that may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein that may bind to the Ter region of rDNA; interacts physically with Fob1p NP_010309.1 492553 R 4932 CDS NP_010310.1 6320230 851591 complement(494646..497315) 1 NC_001136.8 Vps54p; Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; potentially phosphorylated by Cdc28p 497315 VPS54 851591 VPS54 Saccharomyces cerevisiae Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; potentially phosphorylated by Cdc28p NP_010310.1 494646 R 4932 CDS NP_010311.1 6320231 851592 complement(497832..500876) 1 NC_001136.8 Regulatory subunit of type 1 protein phosphatase Glc7p, involved in negative regulation of glucose-repressible genes; Reg1p 500876 REG1 851592 REG1 Saccharomyces cerevisiae Reg1p NP_010311.1 497832 R 4932 CDS NP_010313.1 6320233 851594 complement(501750..503270) 1 NC_001136.8 Rad28p; Protein involved in transcription-coupled repair nucleotide excision repair of UV-induced DNA lesions; homolog of human CSA protein 503270 RAD28 851594 RAD28 Saccharomyces cerevisiae Protein involved in transcription-coupled repair nucleotide excision repair of UV-induced DNA lesions; homolog of human CSA protein NP_010313.1 501750 R 4932 CDS NP_010314.2 50593139 851595 503495..503860 1 NC_001136.8 Mitochondrial intermembrane space cysteine motif protein of 14 kDa; Mic14p 503860 MIC14 851595 MIC14 Saccharomyces cerevisiae Mic14p NP_010314.2 503495 D 4932 CDS NP_010315.1 6320235 851596 complement(504096..504692) 1 NC_001136.8 Pst2p; Protein with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 504692 PST2 851596 PST2 Saccharomyces cerevisiae Protein with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_010315.1 504096 R 4932 CDS NP_010316.1 6320236 851597 508144..509106 1 NC_001136.8 Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p; Mrh1p 509106 MRH1 851597 MRH1 Saccharomyces cerevisiae Mrh1p NP_010316.1 508144 D 4932 CDS NP_010317.1 6320237 851598 complement(509734..512106) 1 NC_001136.8 Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer; Lys14p 512106 LYS14 851598 LYS14 Saccharomyces cerevisiae Lys14p NP_010317.1 509734 R 4932 CDS NP_058138.1 7839150 851599 complement(join(514040..518059,518061..519353)) 1 NC_001136.8 Ydr034c-dp; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 519353 851599 YDR034C-D Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_058138.1 514040 R 4932 CDS NP_058139.1 7839149 851600 complement(518037..519353) 1 NC_001136.8 Ydr034c-cp; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 519353 851600 YDR034C-C Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_058139.1 518037 R 4932 CDS NP_010318.1 6320238 851602 complement(520513..520689) 1 NC_001136.8 Ydr034c-ap; Putative protein of unknown function; contained within the solo Ty1 LTR element YDRWdelta7 520689 851602 YDR034C-A Saccharomyces cerevisiae Putative protein of unknown function; contained within the solo Ty1 LTR element YDRWdelta7 NP_010318.1 520513 R 4932 CDS NP_010319.1 6320239 851604 521311..521466 1 NC_001136.8 Ydr034w-bp; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery 521466 851604 YDR034W-B Saccharomyces cerevisiae Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery NP_010319.1 521311 D 4932 CDS NP_010320.1 6320240 851605 521813..522925 1 NC_001136.8 Aro3p; 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan 522925 ARO3 851605 ARO3 Saccharomyces cerevisiae 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan NP_010320.1 521813 D 4932 CDS NP_010321.1 6320241 851606 complement(523208..524710) 1 NC_001136.8 Ehd3p; 3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis 524710 EHD3 851606 EHD3 Saccharomyces cerevisiae 3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis NP_010321.1 523208 R 4932 CDS NP_010322.1 6320242 851607 525437..527212 1 NC_001136.8 Lysyl-tRNA synthetase; also identified as a negative regulator of general control of amino acid biosynthesis; Krs1p 527212 KRS1 851607 KRS1 Saccharomyces cerevisiae Krs1p NP_010322.1 525437 D 4932 CDS NP_010323.1 6320243 851608 complement(527419..530694) 1 NC_001136.8 Protein with similarity to P-type ATPase sodium pumps, member of the Na+ efflux ATPase family; Ena5p 530694 ENA5 851608 ENA5 Saccharomyces cerevisiae Ena5p NP_010323.1 527419 R 4932 CDS NP_010324.1 6320244 851609 complement(531304..534579) 1 NC_001136.8 P-type ATPase sodium pump, involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux; Ena2p 534579 ENA2 851609 ENA2 Saccharomyces cerevisiae Ena2p NP_010324.1 531304 R 4932 CDS NP_010325.1 6320245 851610 complement(535189..538464) 1 NC_001136.8 P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance; Ena1p 538464 ENA1 851610 ENA1 Saccharomyces cerevisiae Ena1p NP_010325.1 535189 R 4932 CDS NP_010326.1 6320246 851611 539800..540411 1 NC_001136.8 Rsm10p; Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins 540411 RSM10 851611 RSM10 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins NP_010326.1 539800 D 4932 CDS NP_010327.1 6320247 851612 complement(540598..541200) 1 NC_001136.8 Ydr042cp; Putative protein of unknown function; expression is increased in ssu72-ts69 mutant 541200 851612 YDR042C Saccharomyces cerevisiae Putative protein of unknown function; expression is increased in ssu72-ts69 mutant NP_010327.1 540598 R 4932 CDS NP_010328.1 6320248 851613 complement(542672..543367) 1 NC_001136.8 Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response; Nrg1p 543367 NRG1 851613 NRG1 Saccharomyces cerevisiae Nrg1p NP_010328.1 542672 R 4932 CDS NP_010329.1 6320249 851614 546640..547626 1 NC_001136.8 Hem13p; Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p) 547626 HEM13 851614 HEM13 Saccharomyces cerevisiae Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p) NP_010329.1 546640 D 4932 CDS NP_010330.1 6320250 851615 complement(547976..548308) 1 NC_001136.8 Rpc11p; RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS 548308 RPC11 851615 RPC11 Saccharomyces cerevisiae RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS NP_010330.1 547976 R 4932 CDS NP_010331.1 6320251 851616 complement(548760..550574) 1 NC_001136.8 Bap3p; Amino acid permease involved in the uptake of cysteine, leucine, isoleucine and valine 550574 BAP3 851616 BAP3 Saccharomyces cerevisiae Amino acid permease involved in the uptake of cysteine, leucine, isoleucine and valine NP_010331.1 548760 R 4932 CDS NP_010332.1 6320252 851617 551858..552946 1 NC_001136.8 Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; activity inhibited by Cu2+, Zn2+, Fe2+, Fe3+ and sulfhydryl-specific reagents; Hem12p 552946 HEM12 851617 HEM12 Saccharomyces cerevisiae Hem12p NP_010332.1 551858 D 4932 CDS NP_010334.1 6320253 851618 553252..555150 1 NC_001136.8 Zinc finger protein; putative transcription factor that may interact with proteins involved in histone acetylation or deacetylation; may be involved in altering acetylation on histone lysines; Ydr049wp 555150 851618 YDR049W Saccharomyces cerevisiae Ydr049wp NP_010334.1 553252 D 4932 CDS NP_010335.1 6320255 851620 complement(555724..556470) 1 NC_001136.8 Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; Tpi1p 556470 TPI1 851620 TPI1 Saccharomyces cerevisiae Tpi1p NP_010335.1 555724 R 4932 CDS NP_010336.1 6320256 851621 complement(557054..558058) 1 NC_001136.8 Ydr051cp; Protein of unknown function; interacts with Hsp82p in two-hybrid assay; deletion confers sensitivity to Nickel 558058 851621 YDR051C Saccharomyces cerevisiae Protein of unknown function; interacts with Hsp82p in two-hybrid assay; deletion confers sensitivity to Nickel NP_010336.1 557054 R 4932 CDS NP_010337.1 6320258 851623 complement(558509..560623) 1 NC_001136.8 Regulatory subunit of Cdc7p-Dbf4p kinase complex, required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; Dbf4p 560623 DBF4 851623 DBF4 Saccharomyces cerevisiae Dbf4p NP_010337.1 558509 R 4932 CDS NP_010339.1 6320259 851624 complement(561438..562325) 1 NC_001136.8 Ubiquitin-conjugating enzyme (E2) and catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; Cdc34p 562325 CDC34 851624 CDC34 Saccharomyces cerevisiae Cdc34p NP_010339.1 561438 R 4932 CDS NP_010340.1 6320260 851625 563525..564859 1 NC_001136.8 Pst1p; Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1 564859 PST1 851625 PST1 Saccharomyces cerevisiae Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1 NP_010340.1 563525 D 4932 CDS NP_010341.1 6320261 851626 complement(565021..565638) 1 NC_001136.8 Ydr056cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic retiuculum; YDR056C is not an essential protein 565638 851626 YDR056C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic retiuculum; YDR056C is not an essential protein NP_010341.1 565021 R 4932 CDS NP_010342.1 6320262 851627 565925..567553 1 NC_001136.8 Yos9p; ER quality-control lectin; integral subunit of the HRD ligase; serves as a receptor for misfolded N-glycosylated proteins, participates in their targeting to ERAD; member of the OS-9 protein family 567553 YOS9 851627 YOS9 Saccharomyces cerevisiae ER quality-control lectin; integral subunit of the HRD ligase; serves as a receptor for misfolded N-glycosylated proteins, participates in their targeting to ERAD; member of the OS-9 protein family NP_010342.1 565925 D 4932 CDS NP_010343.1 6320263 851628 complement(567721..568701) 1 NC_001136.8 Tgl2p; Protein with lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli; role in yeast lipid degradation is unclear 568701 TGL2 851628 TGL2 Saccharomyces cerevisiae Protein with lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli; role in yeast lipid degradation is unclear NP_010343.1 567721 R 4932 CDS NP_010344.1 6320264 851631 complement(join(569232..569631,569722..569768)) 1 NC_001136.8 Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins, central component of the cellular stress response; expression is heat inducible; Ubc5p 569768 UBC5 851631 UBC5 Saccharomyces cerevisiae Ubc5p NP_010344.1 569232 R 4932 CDS NP_010345.1 6320265 851632 570646..573723 1 NC_001136.8 Mak21p; Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein 573723 MAK21 851632 MAK21 Saccharomyces cerevisiae Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein NP_010345.1 570646 D 4932 CDS NP_010346.1 6320266 851633 574161..575780 1 NC_001136.8 Ydr061wp; Protein with similarity to ATP-binding cassette (ABC) transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance 575780 851633 YDR061W Saccharomyces cerevisiae Protein with similarity to ATP-binding cassette (ABC) transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance NP_010346.1 574161 D 4932 CDS NP_010347.1 6320267 851634 576471..578156 1 NC_001136.8 Lcb2p; Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine 578156 LCB2 851634 LCB2 Saccharomyces cerevisiae Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine NP_010347.1 576471 D 4932 CDS NP_010348.1 6320268 851635 578661..579110 1 NC_001136.8 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is viable and displays decreased frequency of mitochondrial genome loss (petite formation); Aim7p 579110 AIM7 851635 AIM7 Saccharomyces cerevisiae Aim7p NP_010348.1 578661 D 4932 CDS NP_010349.1 6320269 851636 join(579456..579476,580016..580450) 1 NC_001136.8 Rps13p; Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S15 and rat S13 ribosomal proteins 580450 RPS13 851636 RPS13 Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S15 and rat S13 ribosomal proteins NP_010349.1 579456 D 4932 CDS NP_010350.1 6320270 851637 580685..581782 1 NC_001136.8 Ydr065wp; Protein of unknown function, required for vacuolar acidification; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 581782 851637 YDR065W Saccharomyces cerevisiae Protein of unknown function, required for vacuolar acidification; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_010350.1 580685 D 4932 CDS NP_010351.1 6320271 851638 complement(581906..582496) 1 NC_001136.8 Rtr2p; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene 582496 RTR2 851638 RTR2 Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene NP_010351.1 581906 R 4932 CDS NP_010352.1 6320272 851639 complement(582789..583463) 1 NC_001136.8 Oca6p; Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts 583463 OCA6 851639 OCA6 Saccharomyces cerevisiae Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts NP_010352.1 582789 R 4932 CDS NP_010353.1 6320273 851640 583711..584643 1 NC_001136.8 Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; Dos2p 584643 DOS2 851640 DOS2 Saccharomyces cerevisiae Dos2p NP_010353.1 583711 D 4932 CDS NP_010354.1 6320274 851641 complement(584937..587717) 1 NC_001136.8 Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole; Doa4p 587717 DOA4 851641 DOA4 Saccharomyces cerevisiae Doa4p NP_010354.1 584937 R 4932 CDS NP_010355.1 6320275 851642 complement(588096..588377) 1 NC_001136.8 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Fmp16p 588377 FMP16 851642 FMP16 Saccharomyces cerevisiae Fmp16p NP_010355.1 588096 R 4932 CDS NP_010356.1 6320276 851643 complement(588825..589400) 1 NC_001136.8 Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication; Paa1p 589400 PAA1 851643 PAA1 Saccharomyces cerevisiae Paa1p NP_010356.1 588825 R 4932 CDS NP_010357.1 6320277 851644 complement(589759..591342) 1 NC_001136.8 Ipt1p; Inositolphosphotransferase 1, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), which is the most abundant sphingolipid in cells, mutation confers resistance to the antifungals syringomycin E and DmAMP1 in some growth media 591342 IPT1 851644 IPT1 Saccharomyces cerevisiae Inositolphosphotransferase 1, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), which is the most abundant sphingolipid in cells, mutation confers resistance to the antifungals syringomycin E and DmAMP1 in some growth media NP_010357.1 589759 R 4932 CDS NP_010358.1 6320278 851645 592436..592945 1 NC_001136.8 Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p; Snf11p 592945 SNF11 851645 SNF11 Saccharomyces cerevisiae Snf11p NP_010358.1 592436 D 4932 CDS NP_010359.1 6320279 851646 593890..596580 1 NC_001136.8 Tps2p; Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway 596580 TPS2 851646 TPS2 Saccharomyces cerevisiae Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway NP_010359.1 593890 D 4932 CDS NP_010360.1 6320280 851647 597153..598079 1 NC_001136.8 Pph3p; Catalytic subunit of an evolutionarily conserved protein phosphatase complex containing Psy2p and the regulatory subunit Psy4p; required for cisplatin resistance; involved in activation of Gln3p 598079 PPH3 851647 PPH3 Saccharomyces cerevisiae Catalytic subunit of an evolutionarily conserved protein phosphatase complex containing Psy2p and the regulatory subunit Psy4p; required for cisplatin resistance; involved in activation of Gln3p NP_010360.1 597153 D 4932 CDS NP_010361.1 6320281 851648 598465..599685 1 NC_001136.8 Rad55p; Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p 599685 RAD55 851648 RAD55 Saccharomyces cerevisiae Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p NP_010361.1 598465 D 4932 CDS NP_010362.1 6320282 851649 600790..601806 1 NC_001136.8 Sed1p; Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites 601806 SED1 851649 SED1 Saccharomyces cerevisiae Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites NP_010362.1 600790 D 4932 CDS NP_010363.1 6320283 851650 complement(602195..602866) 1 NC_001136.8 Shu2p; Protein of unassigned function involved in mutation suppression, important for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation; associates with Shu1p, Psy3p, and Csm2p 602866 SHU2 851650 SHU2 Saccharomyces cerevisiae Protein of unassigned function involved in mutation suppression, important for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation; associates with Shu1p, Psy3p, and Csm2p NP_010363.1 602195 R 4932 CDS NP_010364.1 6320284 851651 603061..603396 1 NC_001136.8 Pet100p; Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme 603396 PET100 851651 PET100 Saccharomyces cerevisiae Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme NP_010364.1 603061 D 4932 CDS NP_076886.1 13129164 851652 complement(603590..603808) 1 NC_001136.8 Tfb5p; Component of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation; homolog of the Chlamydomonas reinhardtii REX1-S protein which is involved in DNA repair 603808 TFB5 851652 TFB5 Saccharomyces cerevisiae Component of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation; homolog of the Chlamydomonas reinhardtii REX1-S protein which is involved in DNA repair NP_076886.1 603590 R 4932 CDS NP_010365.1 6320285 851653 604005..606983 1 NC_001136.8 Vps41p; Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport 606983 VPS41 851653 VPS41 Saccharomyces cerevisiae Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport NP_010365.1 604005 D 4932 CDS NP_010366.1 6320286 851654 complement(607301..610078) 1 NC_001136.8 Transcription factor required for the synthesis of the glycolytic enzyme pyruvate decarboxylase, required for high level expression of both the THI and the PDC genes; Pdc2p 610078 PDC2 851654 PDC2 Saccharomyces cerevisiae Pdc2p NP_010366.1 607301 R 4932 CDS NP_010367.1 6320287 851655 610438..611922 1 NC_001136.8 Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping; Stn1p 611922 STN1 851655 STN1 Saccharomyces cerevisiae Stn1p NP_010367.1 610438 D 4932 CDS NP_010368.3 85666115 851656 612070..613248 1 NC_001136.8 Rrp8p; Nucleolar protein involved in rRNA processing, pre-rRNA cleavage at site A2; also involved in telomere maintenance; mutation is synthetically lethal with a gar1 mutation 613248 RRP8 851656 RRP8 Saccharomyces cerevisiae Nucleolar protein involved in rRNA processing, pre-rRNA cleavage at site A2; also involved in telomere maintenance; mutation is synthetically lethal with a gar1 mutation NP_010368.3 612070 D 4932 CDS NP_010369.1 6320289 851657 complement(613402..614001) 1 NC_001136.8 Tvp23p; Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 614001 TVP23 851657 TVP23 Saccharomyces cerevisiae Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern NP_010369.1 613402 R 4932 CDS NP_010370.1 6320290 851658 complement(614285..616147) 1 NC_001136.8 Alpha-factor pheromone receptor regulator, negatively regulates pheromone receptor signaling; required for normal mating projection (shmoo) formation; required for Spa2p to recruit Mpk1p to shmoo tip during mating; interacts with Cdc12p; Afr1p 616147 AFR1 851658 AFR1 Saccharomyces cerevisiae Afr1p NP_010370.1 614285 R 4932 CDS NP_010371.1 6320291 851659 complement(616925..617167) 1 NC_001136.8 Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p; Sss1p 617167 SSS1 851659 SSS1 Saccharomyces cerevisiae Sss1p NP_010371.1 616925 R 4932 CDS NP_010372.1 6320292 851660 complement(617467..618303) 1 NC_001136.8 Rrp1p; Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles 618303 RRP1 851660 RRP1 Saccharomyces cerevisiae Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles NP_010372.1 617467 R 4932 CDS NP_010373.1 6320293 851661 complement(618494..619642) 1 NC_001136.8 Slu7p; RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain 619642 SLU7 851661 SLU7 Saccharomyces cerevisiae RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain NP_010373.1 618494 R 4932 CDS NP_010374.1 6320294 851663 622109..624718 1 NC_001136.8 Ydr089wp; Protein of unknown function; deletion confers resistance to Nickel 624718 851663 YDR089W Saccharomyces cerevisiae Protein of unknown function; deletion confers resistance to Nickel NP_010374.1 622109 D 4932 CDS NP_010375.1 6320295 851664 complement(625063..625995) 1 NC_001136.8 Ydr090cp; Putative protein of unknown function 625995 851664 YDR090C Saccharomyces cerevisiae Putative protein of unknown function NP_010375.1 625063 R 4932 CDS NP_010376.1 6320296 851665 complement(626705..628531) 1 NC_001136.8 Rli1p; Essential iron-sulfur protein required for ribosome biogenesis and translation initiation; facilitates binding of a multifactor complex (MFC) of translation initiation factors to the small ribosomal subunit; predicted ABC family ATPase 628531 RLI1 851665 RLI1 Saccharomyces cerevisiae Essential iron-sulfur protein required for ribosome biogenesis and translation initiation; facilitates binding of a multifactor complex (MFC) of translation initiation factors to the small ribosomal subunit; predicted ABC family ATPase NP_010376.1 626705 R 4932 CDS NP_010377.1 6320297 851666 join(629873..629902,630171..630602) 1 NC_001136.8 Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus; Ubc13p 630602 UBC13 851666 UBC13 Saccharomyces cerevisiae Ubc13p NP_010377.1 629873 D 4932 CDS NP_010378.1 6320298 851667 631279..636117 1 NC_001136.8 Dnf2p; Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase 636117 DNF2 851667 DNF2 Saccharomyces cerevisiae Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase NP_010378.1 631279 D 4932 CDS NP_010381.1 6320301 851670 637136..639820 1 NC_001136.8 JmjC domain-containing histone demethylase; transcription factor involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1; Gis1p 639820 GIS1 851670 GIS1 Saccharomyces cerevisiae Gis1p NP_010381.1 637136 D 4932 CDS NP_010382.1 6320302 851671 complement(640106..643834) 1 NC_001136.8 Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; potentially phosphorylated by Cdc28p; Msh6p 643834 MSH6 851671 MSH6 Saccharomyces cerevisiae Msh6p NP_010382.1 640106 R 4932 CDS NP_010383.1 6320303 851672 complement(644175..645032) 1 NC_001136.8 Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage; Grx3p 645032 GRX3 851672 GRX3 Saccharomyces cerevisiae Grx3p NP_010383.1 644175 R 4932 CDS NP_058140.1 7839152 851674 complement(join(645855..649817,649819..651123)) 1 NC_001136.8 Ydr098c-bp; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 651123 851674 YDR098C-B Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_058140.1 645855 R 4932 CDS NP_058141.1 7839151 851675 complement(649801..651123) 1 NC_001136.8 Ydr098c-ap; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 651123 851675 YDR098C-A Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_058141.1 649801 R 4932 CDS NP_010384.1 6320304 851676 653604..654425 1 NC_001136.8 Bmh2p; 14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling 654425 BMH2 851676 BMH2 Saccharomyces cerevisiae 14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling NP_010384.1 653604 D 4932 CDS NP_010385.1 6320305 851677 655010..655441 1 NC_001136.8 Tvp15p; Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p 655441 TVP15 851677 TVP15 Saccharomyces cerevisiae Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p NP_010385.1 655010 D 4932 CDS NP_010386.1 6320306 851678 complement(655683..657464) 1 NC_001136.8 Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex; Arx1p 657464 ARX1 851678 ARX1 Saccharomyces cerevisiae Arx1p NP_010386.1 655683 R 4932 CDS NP_010388.1 6320308 851680 658347..661100 1 NC_001136.8 Ste5p; Pheromone-response scaffold protein; binds kinases Ste11p, Ste7p, and Fus3p to form a MAPK cascade complex that interacts with the plasma membrane, via a PH (pleckstrin homology) and PM/NLS domain, and with Ste4p-Ste18p, during signaling 661100 STE5 851680 STE5 Saccharomyces cerevisiae Pheromone-response scaffold protein; binds kinases Ste11p, Ste7p, and Fus3p to form a MAPK cascade complex that interacts with the plasma membrane, via a PH (pleckstrin homology) and PM/NLS domain, and with Ste4p-Ste18p, during signaling NP_010388.1 658347 D 4932 CDS NP_010389.1 6320309 851681 complement(661170..664907) 1 NC_001136.8 Spo71p; Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis 664907 SPO71 851681 SPO71 Saccharomyces cerevisiae Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis NP_010389.1 661170 R 4932 CDS NP_010390.1 6320310 851682 complement(665346..666767) 1 NC_001136.8 Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance; Tms1p 666767 TMS1 851682 TMS1 Saccharomyces cerevisiae Tms1p NP_010390.1 665346 R 4932 CDS NP_010391.1 6320311 851683 667001..667855 1 NC_001136.8 Component of the dynactin complex, localized to the pointed end of the Arp1p filament; may regulate membrane association of the complex; Arp10p 667855 ARP10 851683 ARP10 Saccharomyces cerevisiae Arp10p NP_010391.1 667001 D 4932 CDS NP_010392.1 6320312 851685 complement(669013..671031) 1 NC_001136.8 Tmn2p; Multispanning membrane protein of unknown function 671031 TMN2 851685 TMN2 Saccharomyces cerevisiae Multispanning membrane protein of unknown function NP_010392.1 669013 R 4932 CDS NP_010393.1 6320313 851686 671266..673362 1 NC_001136.8 Subunit of TRAPP (transport protein particle), a multi-subunit complex involved in targeting and/or fusion of ER-to-Golgi transport vesicles with their acceptor compartment; protein has late meiotic role, following DNA replication; Gsg1p 673362 GSG1 851686 GSG1 Saccharomyces cerevisiae Gsg1p NP_010393.1 671266 D 4932 CDS NP_010394.1 6320314 851687 complement(673517..675664) 1 NC_001136.8 Ydr109cp; Putative kinase 675664 851687 YDR109C Saccharomyces cerevisiae Putative kinase NP_010394.1 673517 R 4932 CDS NP_010395.1 6320315 851688 676099..677799 1 NC_001136.8 Nucleolar protein required for DNA replication fork blocking and recombinational hotspot activities; binds to the replication fork barrier site in the rDNA region; related to retroviral integrases; Fob1p 677799 FOB1 851688 FOB1 Saccharomyces cerevisiae Fob1p NP_010395.1 676099 D 4932 CDS NP_010396.1 6320317 851690 complement(678238..679761) 1 NC_001136.8 Putative alanine transaminase (glutamic pyruvic transaminase); Alt2p 679761 ALT2 851690 ALT2 Saccharomyces cerevisiae Alt2p NP_010396.1 678238 R 4932 CDS NP_010398.1 6320318 851691 complement(680493..681614) 1 NC_001136.8 Securin that inhibits anaphase by binding separin Esp1p, also blocks cyclin destruction and mitotic exit, essential for cell cycle arrest in mitosis in the presence of DNA damage or aberrant mitotic spindles; also present in meiotic nuclei; Pds1p 681614 PDS1 851691 PDS1 Saccharomyces cerevisiae Pds1p NP_010398.1 680493 R 4932 CDS NP_010399.1 6320320 851693 complement(681921..682223) 1 NC_001136.8 Ydr114cp; Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium 682223 851693 YDR114C Saccharomyces cerevisiae Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium NP_010399.1 681921 R 4932 CDS NP_010400.1 6320319 851692 682172..682489 1 NC_001136.8 Ydr115wp; Putative mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins 682489 851692 YDR115W Saccharomyces cerevisiae Putative mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins NP_010400.1 682172 D 4932 CDS NP_010401.1 6320321 851694 complement(682721..683578) 1 NC_001136.8 Mrpl1p; Mitochondrial ribosomal protein of the large subunit 683578 MRPL1 851694 MRPL1 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit NP_010401.1 682721 R 4932 CDS NP_010402.1 6320322 851695 complement(683943..685640) 1 NC_001136.8 Tma64p; Protein of unknown function that associates with ribosomes; has a putative RNA binding domain 685640 TMA64 851695 TMA64 Saccharomyces cerevisiae Protein of unknown function that associates with ribosomes; has a putative RNA binding domain NP_010402.1 683943 R 4932 CDS NP_010403.1 6320323 851696 685879..687837 1 NC_001136.8 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; Apc4p 687837 APC4 851696 APC4 Saccharomyces cerevisiae Apc4p NP_010403.1 685879 D 4932 CDS NP_010404.1 6320324 851697 688224..690530 1 NC_001136.8 Ydr119wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to vacuolar membrane; YDR119W is not an essential gene 690530 851697 YDR119W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to vacuolar membrane; YDR119W is not an essential gene NP_010404.1 688224 D 4932 CDS NP_001032575.1 82795245 3799970 691011..691211 1 NC_001136.8 Ydr119w-ap; Putative protein of unknown function 691211 3799970 YDR119W-A Saccharomyces cerevisiae Putative protein of unknown function NP_001032575.1 691011 D 4932 CDS NP_010405.1 6320325 851698 complement(691546..693258) 1 NC_001136.8 tRNA methyltransferase, localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments; Trm1p 693258 TRM1 851698 TRM1 Saccharomyces cerevisiae Trm1p NP_010405.1 691546 R 4932 CDS NP_010406.1 6320326 851699 693582..694172 1 NC_001136.8 Shared subunit of DNA polymerase (II) epsilon and of ISW2/yCHRAC chromatin accessibility complex; involved in both chromosomal DNA replication and in inheritance of telomeric silencing; Dpb4p 694172 DPB4 851699 DPB4 Saccharomyces cerevisiae Dpb4p NP_010406.1 693582 D 4932 CDS NP_010407.1 6320327 851700 694697..697891 1 NC_001136.8 Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p; Kin1p 697891 KIN1 851700 KIN1 Saccharomyces cerevisiae Kin1p NP_010407.1 694697 D 4932 CDS NP_010408.1 6320328 851701 complement(698551..699465) 1 NC_001136.8 Ino2p; Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion 699465 INO2 851701 INO2 Saccharomyces cerevisiae Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion NP_010408.1 698551 R 4932 CDS NP_010409.1 6320329 851702 700312..701286 1 NC_001136.8 Ydr124wp; Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor 701286 851702 YDR124W Saccharomyces cerevisiae Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor NP_010409.1 700312 D 4932 CDS NP_010410.1 6320330 851703 complement(701394..702755) 1 NC_001136.8 Protein of unknown function, similar to Rlp24p; Ecm18p 702755 ECM18 851703 ECM18 Saccharomyces cerevisiae Ecm18p NP_010410.1 701394 R 4932 CDS NP_010411.1 6320331 851704 703231..704241 1 NC_001136.8 Swf1p; Palmitoyltransferase that acts on the SNAREs Snc1p, Syn8p, Tlg1p and likely on all SNAREs; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion 704241 SWF1 851704 SWF1 Saccharomyces cerevisiae Palmitoyltransferase that acts on the SNAREs Snc1p, Syn8p, Tlg1p and likely on all SNAREs; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion NP_010411.1 703231 D 4932 CDS NP_010412.1 6320332 851705 704481..709247 1 NC_001136.8 Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids; Aro1p 709247 ARO1 851705 ARO1 Saccharomyces cerevisiae Aro1p NP_010412.1 704481 D 4932 CDS NP_010413.1 6320333 851706 709546..712992 1 NC_001136.8 Ydr128wp; Putative protein of unknown function 712992 851706 YDR128W Saccharomyces cerevisiae Putative protein of unknown function NP_010413.1 709546 D 4932 CDS NP_010414.1 6320334 851707 complement(join(713337..715244,715356..715376)) 1 NC_001136.8 Sac6p; Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton 715376 SAC6 851707 SAC6 Saccharomyces cerevisiae Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton NP_010414.1 713337 R 4932 CDS NP_010415.1 6320335 851708 complement(715744..716619) 1 NC_001136.8 Spindle pole body-related intermediate filament protein, forms cell cycle-specific filaments between spindle pole bodies in mother and daughter cells, able to self-assemble, expression induced during S/G2, localization cell-cycle dependent; Fin1p 716619 FIN1 851708 FIN1 Saccharomyces cerevisiae Fin1p NP_010415.1 715744 R 4932 CDS NP_010416.1 6320336 851709 complement(716787..718457) 1 NC_001136.8 Ydr131cp; F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex 718457 851709 YDR131C Saccharomyces cerevisiae F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex NP_010416.1 716787 R 4932 CDS NP_010417.1 6320337 851710 complement(718813..720300) 1 NC_001136.8 Ydr132cp; Putative protein of unknown function 720300 851710 YDR132C Saccharomyces cerevisiae Putative protein of unknown function NP_010417.1 718813 R 4932 CDS NP_010419.1 6320339 851713 complement(723001..727548) 1 NC_001136.8 Ycf1p; Vacuolar glutathione S-conjugate transporter of the ATP-binding cassette family, has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin; similar to human cystic fibrosis protein CFTR 727548 YCF1 851713 YCF1 Saccharomyces cerevisiae Vacuolar glutathione S-conjugate transporter of the ATP-binding cassette family, has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin; similar to human cystic fibrosis protein CFTR NP_010419.1 723001 R 4932 CDS NP_010421.1 6320340 851714 728256..730247 1 NC_001136.8 Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p; Rgp1p 730247 RGP1 851714 RGP1 Saccharomyces cerevisiae Rgp1p NP_010421.1 728256 D 4932 CDS NP_010422.1 6320342 851716 730575..732833 1 NC_001136.8 Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p; Hpr1p 732833 HPR1 851716 HPR1 Saccharomyces cerevisiae Hpr1p NP_010422.1 730575 D 4932 CDS NP_010423.2 9755329 851717 complement(join(733615..733699,733773..733921)) 1 NC_001136.8 Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme); Rub1p 733921 RUB1 851717 RUB1 Saccharomyces cerevisiae Rub1p NP_010423.2 733615 R 4932 CDS NP_010424.1 6320344 851718 734135..734800 1 NC_001136.8 S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; methylates release factor eRF1 (Sup45p) in vitro; is not an essential gene; similar to E.coli PrmC; Mtq2p 734800 MTQ2 851718 MTQ2 Saccharomyces cerevisiae Mtq2p NP_010424.1 734135 D 4932 CDS NP_010425.1 6320345 851719 complement(734898..739994) 1 NC_001136.8 Protein of unknown function, essential for viability, involved in establishing cellular polarity and morphogenesis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Dop1p 739994 DOP1 851719 DOP1 Saccharomyces cerevisiae Dop1p NP_010425.1 734898 R 4932 CDS NP_010426.1 6320346 851720 complement(740470..741597) 1 NC_001136.8 Pex7p; Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP) 741597 PEX7 851720 PEX7 Saccharomyces cerevisiae Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP) NP_010426.1 740470 R 4932 CDS NP_010427.1 6320347 851721 complement(742039..743871) 1 NC_001136.8 Ubiquitin-protein ligase, involved in the proteasome-dependent degradation of aberrant nuclear proteins; San1p 743871 SAN1 851721 SAN1 Saccharomyces cerevisiae San1p NP_010427.1 742039 R 4932 CDS NP_010428.1 6320348 851722 complement(744308..746098) 1 NC_001136.8 Mkc7p; GPI-anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p 746098 MKC7 851722 MKC7 Saccharomyces cerevisiae GPI-anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p NP_010428.1 744308 R 4932 CDS NP_010429.1 6320349 851723 746735..748354 1 NC_001136.8 Taf12p; Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A 748354 TAF12 851723 TAF12 Saccharomyces cerevisiae Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A NP_010429.1 746735 D 4932 CDS NP_010430.1 6320350 851724 complement(748610..750739) 1 NC_001136.8 Transcription factor that activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; localization to the nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase; Swi5p 750739 SWI5 851724 SWI5 Saccharomyces cerevisiae Swi5p NP_010430.1 748610 R 4932 CDS NP_010431.1 6320351 851725 751628..753232 1 NC_001136.8 Ethanolamine kinase, primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway; Eki1p 753232 EKI1 851725 EKI1 Saccharomyces cerevisiae Eki1p NP_010431.1 751628 D 4932 CDS NP_010432.1 6320352 851726 complement(753672..755063) 1 NC_001136.8 Kgd2p; Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated 755063 KGD2 851726 KGD2 Saccharomyces cerevisiae Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated NP_010432.1 753672 R 4932 CDS NP_010434.1 6320353 851727 755625..763871 1 NC_001136.8 Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex; Num1p 763871 NUM1 851727 NUM1 Saccharomyces cerevisiae Num1p NP_010434.1 755625 D 4932 CDS NP_010435.1 6320355 851729 complement(764175..765152) 1 NC_001136.8 Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis; Cth1p 765152 CTH1 851729 CTH1 Saccharomyces cerevisiae Cth1p NP_010435.1 764175 R 4932 CDS NP_010436.1 6320356 851730 765703..766500 1 NC_001136.8 Highly-acidic cytoplasmic RWD domain-containing protein of unknown function, sensitive to proteolysis, N-terminal region has high content of acidic amino acid residues, putative IUP (intrinsically unstructured protein); Gir2p 766500 GIR2 851730 GIR2 Saccharomyces cerevisiae Gir2p NP_010436.1 765703 D 4932 CDS NP_010437.1 6320357 851731 complement(766733..767968) 1 NC_001136.8 Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin; Ent5p 767968 ENT5 851731 ENT5 Saccharomyces cerevisiae Ent5p NP_010437.1 766733 R 4932 CDS NP_010439.1 6320359 851733 complement(768509..768997) 1 NC_001136.8 Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A; Cpr1p 768997 CPR1 851733 CPR1 Saccharomyces cerevisiae Cpr1p NP_010439.1 768509 R 4932 CDS NP_010440.1 6320360 851734 769522..769935 1 NC_001136.8 Rpa14p; RNA polymerase I subunit A14 769935 RPA14 851734 RPA14 Saccharomyces cerevisiae RNA polymerase I subunit A14 NP_010440.1 769522 D 4932 CDS NP_010442.1 6320362 851736 770354..771451 1 NC_001136.8 Hom2p; Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis 771451 HOM2 851736 HOM2 Saccharomyces cerevisiae Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis NP_010442.1 770354 D 4932 CDS NP_010443.1 6320363 851737 771874..775779 1 NC_001136.8 Sac3p; Nuclear pore-associated protein, forms a complex with Thp1p that is involved in transcription and in mRNA export from the nucleus 775779 SAC3 851737 SAC3 Saccharomyces cerevisiae Nuclear pore-associated protein, forms a complex with Thp1p that is involved in transcription and in mRNA export from the nucleus NP_010443.1 771874 D 4932 CDS NP_010444.1 6320364 851738 776160..778718 1 NC_001136.8 Ssy1p; Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes 778718 SSY1 851738 SSY1 Saccharomyces cerevisiae Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes NP_010444.1 776160 D 4932 CDS NP_010445.1 6320365 851739 779040..780203 1 NC_001136.8 Ydr161wp; Putative protein of unknown function; non-essential gene; proposed function in rRNA and ribosome biosynthesis based on transcriptional co-regulation 780203 851739 YDR161W Saccharomyces cerevisiae Putative protein of unknown function; non-essential gene; proposed function in rRNA and ribosome biosynthesis based on transcriptional co-regulation NP_010445.1 779040 D 4932 CDS NP_010446.1 6320366 851740 complement(780387..781097) 1 NC_001136.8 Protein involved in the HOG (high osmolarity glycerol) pathway, negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex, found in the nucleus and cytoplasm, contains an SH3 domain that binds Pbs2p; Nbp2p 781097 NBP2 851740 NBP2 Saccharomyces cerevisiae Nbp2p NP_010446.1 780387 R 4932 CDS NP_010447.1 6320367 851741 781420..781947 1 NC_001136.8 Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p; Cwc15p 781947 CWC15 851741 CWC15 Saccharomyces cerevisiae Cwc15p NP_010447.1 781420 D 4932 CDS NP_010448.1 6320368 851742 complement(782038..784212) 1 NC_001136.8 Sm-like protein involved in docking and fusion of exocytic vesicles through binding to assembled SNARE complexes at the membrane; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function; Sec1p 784212 SEC1 851742 SEC1 Saccharomyces cerevisiae Sec1p NP_010448.1 782038 R 4932 CDS NP_010449.1 6320369 851743 784868..786202 1 NC_001136.8 Trm82p; Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA 786202 TRM82 851743 TRM82 Saccharomyces cerevisiae Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA NP_010449.1 784868 D 4932 CDS NP_010450.1 6320370 851744 complement(786303..789218) 1 NC_001136.8 Sec5p; Essential 107kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis 789218 SEC5 851744 SEC5 Saccharomyces cerevisiae Essential 107kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis NP_010450.1 786303 R 4932 CDS NP_010451.1 6320371 851745 789446..790066 1 NC_001136.8 Taf10p; Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification 790066 TAF10 851745 TAF10 Saccharomyces cerevisiae Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification NP_010451.1 789446 D 4932 CDS NP_010452.1 6320372 851746 790325..791845 1 NC_001136.8 Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding; Cdc37p 791845 CDC37 851746 CDC37 Saccharomyces cerevisiae Cdc37p NP_010452.1 790325 D 4932 CDS NP_010453.1 6320373 851747 complement(792345..793886) 1 NC_001136.8 Stb3p; Protein that binds Sin3p in a two-hybrid assay 793886 STB3 851747 STB3 Saccharomyces cerevisiae Protein that binds Sin3p in a two-hybrid assay NP_010453.1 792345 R 4932 CDS NP_878062.1 33438780 1466433 complement(794571..794720) 1 NC_001136.8 Ydr169c-ap; Putative protein of unknown function; identified by fungal homology and RT-PCR 794720 1466433 YDR169C-A Saccharomyces cerevisiae Putative protein of unknown function; identified by fungal homology and RT-PCR NP_878062.1 794571 R 4932 CDS NP_010454.1 6320374 851748 complement(796190..802219) 1 NC_001136.8 Sec7p; Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles 802219 SEC7 851748 SEC7 Saccharomyces cerevisiae Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles NP_010454.1 796190 R 4932 CDS NP_010455.1 6320375 851750 803192..804514 1 NC_001136.8 Ydr170w-ap; Retrotransposon TYA Gag gene; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag; YDR170W-A is part of a mutant retrotransposon 804514 851750 YDR170W-A Saccharomyces cerevisiae Retrotransposon TYA Gag gene; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag; YDR170W-A is part of a mutant retrotransposon NP_010455.1 803192 D 4932 CDS NP_010456.1 6320376 851751 806618..807745 1 NC_001136.8 Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; Hsp42p 807745 HSP42 851751 HSP42 Saccharomyces cerevisiae Hsp42p NP_010456.1 806618 D 4932 CDS NP_010457.1 6320377 851752 808321..810378 1 NC_001136.8 Translation termination factor eRF3; altered protein conformation creates the [PSI(+)] prion, a dominant cytoplasmically inherited protein aggregate that alters translational fidelity and creates a nonsense suppressor phenotype; Sup35p 810378 SUP35 851752 SUP35 Saccharomyces cerevisiae Sup35p NP_010457.1 808321 D 4932 CDS NP_010458.1 6320378 851753 complement(810562..811629) 1 NC_001136.8 Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes; Arg82p 811629 ARG82 851753 ARG82 Saccharomyces cerevisiae Arg82p NP_010458.1 810562 R 4932 CDS NP_010459.1 6320379 851754 812107..812847 1 NC_001136.8 Hmo1p; Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase 812847 HMO1 851754 HMO1 Saccharomyces cerevisiae Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase NP_010459.1 812107 D 4932 CDS NP_010460.1 6320380 851755 complement(813190..814149) 1 NC_001136.8 Rsm24p; Mitochondrial ribosomal protein of the small subunit 814149 RSM24 851755 RSM24 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the small subunit NP_010460.1 813190 R 4932 CDS NP_010461.1 6320381 851756 814449..816557 1 NC_001136.8 Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex; Ngg1p 816557 NGG1 851756 NGG1 Saccharomyces cerevisiae Ngg1p NP_010461.1 814449 D 4932 CDS NP_010462.1 6320382 851757 816875..817522 1 NC_001136.8 Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response; Ubc1p 817522 UBC1 851757 UBC1 Saccharomyces cerevisiae Ubc1p NP_010462.1 816875 D 4932 CDS NP_010463.1 6320383 851758 817947..818492 1 NC_001136.8 Sdh4p; Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone 818492 SDH4 851758 SDH4 Saccharomyces cerevisiae Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone NP_010463.1 817947 D 4932 CDS NP_010464.1 6320384 851759 complement(818705..819193) 1 NC_001136.8 Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; Csn9p 819193 CSN9 851759 CSN9 Saccharomyces cerevisiae Csn9p NP_010464.1 818705 R 4932 CDS NP_010465.2 50593140 851760 819430..820821 1 NC_001136.8 Ydr179w-ap; Putative protein of unknown function 820821 851760 YDR179W-A Saccharomyces cerevisiae Putative protein of unknown function NP_010465.2 819430 D 4932 CDS NP_010466.1 6320386 851761 821292..825773 1 NC_001136.8 Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; Scc2p 825773 SCC2 851761 SCC2 Saccharomyces cerevisiae Scc2p NP_010466.1 821292 D 4932 CDS NP_010467.1 6320387 851762 complement(825907..827352) 1 NC_001136.8 Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p; Sas4p 827352 SAS4 851762 SAS4 Saccharomyces cerevisiae Sas4p NP_010467.1 825907 R 4932 CDS NP_010468.1 6320388 851763 827579..829054 1 NC_001136.8 Putative membrane protein of unknown function involved in Mn2+ homeostasis; mutants display actin and general growth defects, heterogeneous cell cycle arrests, and pleiotropic defects in cell cycle progression and organelle distribution; Cdc1p 829054 CDC1 851763 CDC1 Saccharomyces cerevisiae Cdc1p NP_010468.1 827579 D 4932 CDS NP_878063.1 33438781 1466434 829148..829351 1 NC_001136.8 Ydr182w-ap; Putative protein of unknown function; identified by fungal homology and RT-PCR 829351 1466434 YDR182W-A Saccharomyces cerevisiae Putative protein of unknown function; identified by fungal homology and RT-PCR NP_878063.1 829148 D 4932 CDS NP_010469.1 6320389 851764 829582..830274 1 NC_001136.8 Protein with a possible role in folding of beta-tubulin; has weak similarity to phosducins, which are G-protein regulators; Plp1p 830274 PLP1 851764 PLP1 Saccharomyces cerevisiae Plp1p NP_010469.1 829582 D 4932 CDS NP_010470.1 6320390 851765 complement(830626..831510) 1 NC_001136.8 Nuclear protein, possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern; Atc1p 831510 ATC1 851765 ATC1 Saccharomyces cerevisiae Atc1p NP_010470.1 830626 R 4932 CDS NP_010471.1 6320391 851766 complement(831931..832470) 1 NC_001136.8 Ydr185cp; Mitochondrial protein of unknown function; has similarity to Ups1p, which is involved in regulation of alternative topogenesis of the dynamin-related GTPase Mgm1p 832470 851766 YDR185C Saccharomyces cerevisiae Mitochondrial protein of unknown function; has similarity to Ups1p, which is involved in regulation of alternative topogenesis of the dynamin-related GTPase Mgm1p NP_010471.1 831931 R 4932 CDS NP_010472.1 6320392 851767 complement(832856..835489) 1 NC_001136.8 Ydr186cp; Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 835489 851767 YDR186C Saccharomyces cerevisiae Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm NP_010472.1 832856 R 4932 CDS NP_010474.1 6320393 851768 836418..838058 1 NC_001136.8 Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif; Cct6p 838058 CCT6 851768 CCT6 Saccharomyces cerevisiae Cct6p NP_010474.1 836418 D 4932 CDS NP_010475.1 6320395 851770 838389..840389 1 NC_001136.8 Sly1p; Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex 840389 SLY1 851770 SLY1 Saccharomyces cerevisiae Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex NP_010475.1 838389 D 4932 CDS NP_010476.1 6320396 851771 complement(840601..841992) 1 NC_001136.8 Rvb1p; Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; member of the RUVB-like protein family 841992 RVB1 851771 RVB1 Saccharomyces cerevisiae Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; member of the RUVB-like protein family NP_010476.1 840601 R 4932 CDS NP_010477.1 6320397 851772 842334..843446 1 NC_001136.8 Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism; Hst4p 843446 HST4 851772 HST4 Saccharomyces cerevisiae Hst4p NP_010477.1 842334 D 4932 CDS NP_010478.1 6320399 851774 complement(843566..844858) 1 NC_001136.8 Subunit of the nuclear pore complex (NPC) that localizes exclusively to the cytoplasmic side; involved in RNA export, most likely at a terminal step; interacts with Gle1p; Nup42p 844858 NUP42 851774 NUP42 Saccharomyces cerevisiae Nup42p NP_010478.1 843566 R 4932 CDS NP_010480.1 6320400 851775 complement(845949..847943) 1 NC_001136.8 Mss116p; DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing 847943 MSS116 851775 MSS116 Saccharomyces cerevisiae DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing NP_010480.1 845949 R 4932 CDS NP_878064.1 33438782 1466435 848068..848220 1 NC_001136.8 Ydr194w-ap; Putative protein of unknown function; identified by fungal homology and RT-PCR 848220 1466435 YDR194W-A Saccharomyces cerevisiae Putative protein of unknown function; identified by fungal homology and RT-PCR NP_878064.1 848068 D 4932 CDS NP_010481.1 6320401 851776 848596..850197 1 NC_001136.8 Ref2p; RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes 850197 REF2 851776 REF2 Saccharomyces cerevisiae RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes NP_010481.1 848596 D 4932 CDS NP_010482.1 6320402 851777 complement(850271..850996) 1 NC_001136.8 Ydr196cp; Putative dephospho-CoA kinase (DPCK) that catalyzes the final step in Coenzyme A biosynthesis; essential for viability; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 850996 851777 YDR196C Saccharomyces cerevisiae Putative dephospho-CoA kinase (DPCK) that catalyzes the final step in Coenzyme A biosynthesis; essential for viability; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_010482.1 850271 R 4932 CDS NP_010483.1 6320403 851778 851225..852394 1 NC_001136.8 Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader; Cbs2p 852394 CBS2 851778 CBS2 Saccharomyces cerevisiae Cbs2p NP_010483.1 851225 D 4932 CDS NP_010484.1 6320404 851779 complement(852530..853969) 1 NC_001136.8 Rkm2p; Ribosomal protein lysine methyltransferase, responsible for epsilon-trimethylation of the lysine residue at position 10 of Rpl12Ap and Rpl12Bp 853969 RKM2 851779 RKM2 Saccharomyces cerevisiae Ribosomal protein lysine methyltransferase, responsible for epsilon-trimethylation of the lysine residue at position 10 of Rpl12Ap and Rpl12Bp NP_010484.1 852530 R 4932 CDS NP_010486.1 6320406 851781 complement(854276..856090) 1 NC_001136.8 Vps64p; Cytoplasmic protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p, Far7p, Far10p, and Far11p that is involved in pheromone-induced cell cycle arrest; also localized to the endoplasmic reticulum membrane 856090 VPS64 851781 VPS64 Saccharomyces cerevisiae Cytoplasmic protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p, Far7p, Far10p, and Far11p that is involved in pheromone-induced cell cycle arrest; also localized to the endoplasmic reticulum membrane NP_010486.1 854276 R 4932 CDS NP_010487.1 6320407 851782 856314..856811 1 NC_001136.8 Spc19p; Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body 856811 SPC19 851782 SPC19 Saccharomyces cerevisiae Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body NP_010487.1 856314 D 4932 CDS NP_010488.1 6320409 851784 complement(856895..857950) 1 NC_001136.8 Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme; Rav2p 857950 RAV2 851784 RAV2 Saccharomyces cerevisiae Rav2p NP_010488.1 856895 R 4932 CDS NP_010490.1 6320410 851785 858134..859141 1 NC_001136.8 Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex; Coq4p 859141 COQ4 851785 COQ4 Saccharomyces cerevisiae Coq4p NP_010490.1 858134 D 4932 CDS NP_010491.2 37362632 851786 859343..861517 1 NC_001136.8 Msc2p; Member of the cation diffusion facilitator family, localizes to the endoplasmic reticulum and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids 861517 MSC2 851786 MSC2 Saccharomyces cerevisiae Member of the cation diffusion facilitator family, localizes to the endoplasmic reticulum and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids NP_010491.2 859343 D 4932 CDS NP_010492.1 6320412 851787 862051..864705 1 NC_001136.8 Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors; Ebs1p 864705 EBS1 851787 EBS1 Saccharomyces cerevisiae Ebs1p NP_010492.1 862051 D 4932 CDS NP_010493.1 6320413 851788 complement(865009..867519) 1 NC_001136.8 Ume6p; Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p 867519 UME6 851788 UME6 Saccharomyces cerevisiae Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p NP_010493.1 865009 R 4932 CDS NP_010494.1 6320414 851789 868221..870560 1 NC_001136.8 Phosphatidylinositol-4-phosphate 5-kinase, involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation; Mss4p 870560 MSS4 851789 MSS4 Saccharomyces cerevisiae Mss4p NP_010494.1 868221 D 4932 CDS NP_010496.1 6320415 851790 871071..871298 1 NC_001136.8 Ydr210wp; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery 871298 851790 YDR210W Saccharomyces cerevisiae Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery NP_010496.1 871071 D 4932 CDS NP_058142.1 7839154 851793 join(872109..873401,873403..877422) 1 NC_001136.8 Ydr210w-bp; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 877422 851793 YDR210W-B Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_058142.1 872109 D 4932 CDS NP_058143.1 7839153 851792 872109..873425 1 NC_001136.8 Ydr210w-ap; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 873425 851792 YDR210W-A Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_058143.1 872109 D 4932 CDS NP_620387.1 20336767 851794 complement(join(878656..882618,882620..883924)) 1 NC_001136.8 Ydr210c-dp; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 883924 851794 YDR210C-D Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_620387.1 878656 R 4932 CDS NP_620388.1 20336768 851795 complement(882602..883924) 1 NC_001136.8 Ydr210c-cp; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 883924 851795 YDR210C-C Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_620388.1 882602 R 4932 CDS NP_010497.1 6320417 851797 884724..886862 1 NC_001136.8 Gcd6p; Catalytic epsilon subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression 886862 GCD6 851797 GCD6 Saccharomyces cerevisiae Catalytic epsilon subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression NP_010497.1 884724 D 4932 CDS NP_010498.1 6320418 851798 887229..888908 1 NC_001136.8 Tcp1p; Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in maintenance of actin cytoskeleton; homolog to Drosophila melanogaster and mouse tailless complex polypeptide 888908 TCP1 851798 TCP1 Saccharomyces cerevisiae Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in maintenance of actin cytoskeleton; homolog to Drosophila melanogaster and mouse tailless complex polypeptide NP_010498.1 887229 D 4932 CDS NP_010499.1 6320419 851799 889748..892489 1 NC_001136.8 Upc2p; Sterol regulatory element binding protein, induces transcription of sterol transport and biosynthetic genes; involved in the anaerobic induction of DAN/TIR mannoproteins and seripauperins; binucleate zinc cluster protein; Ecm22p homolog 892489 UPC2 851799 UPC2 Saccharomyces cerevisiae Sterol regulatory element binding protein, induces transcription of sterol transport and biosynthetic genes; involved in the anaerobic induction of DAN/TIR mannoproteins and seripauperins; binucleate zinc cluster protein; Ecm22p homolog NP_010499.1 889748 D 4932 CDS NP_010500.1 6320420 851800 892872..893924 1 NC_001136.8 Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock; Aha1p 893924 AHA1 851800 AHA1 Saccharomyces cerevisiae Aha1p NP_010500.1 892872 D 4932 CDS NP_010502.1 6320422 851802 895031..899002 1 NC_001136.8 Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization; Adr1p 899002 ADR1 851802 ADR1 Saccharomyces cerevisiae Adr1p NP_010502.1 895031 D 4932 CDS NP_010503.1 6320423 851803 complement(899547..903476) 1 NC_001136.8 Rad9p; DNA damage-dependent checkpoint protein, required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; potential Cdc28p substrate 903476 RAD9 851803 RAD9 Saccharomyces cerevisiae DNA damage-dependent checkpoint protein, required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; potential Cdc28p substrate NP_010503.1 899547 R 4932 CDS NP_010504.1 6320424 851804 complement(903777..905048) 1 NC_001136.8 Spr28p; Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation 905048 SPR28 851804 SPR28 Saccharomyces cerevisiae Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation NP_010504.1 903777 R 4932 CDS NP_010505.1 6320425 851805 complement(905451..906848) 1 NC_001136.8 Mitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding; Mfb1p 906848 MFB1 851805 MFB1 Saccharomyces cerevisiae Mfb1p NP_010505.1 905451 R 4932 CDS NP_010507.1 6320427 851807 907326..909434 1 NC_001136.8 Gtb1p; Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p, involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER 909434 GTB1 851807 GTB1 Saccharomyces cerevisiae Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p, involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER NP_010507.1 907326 D 4932 CDS NP_010508.1 6320428 851808 910050..911297 1 NC_001136.8 Ydr222wp; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 911297 851808 YDR222W Saccharomyces cerevisiae Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern NP_010508.1 910050 D 4932 CDS NP_010509.1 6320429 851809 912095..913498 1 NC_001136.8 Transcriptional corepressor involved in the regulation of ribosomal protein gene transcription via the TOR signaling pathway and protein kinase A, phosphorylated by activated Yak1p which promotes accumulation of Crf1p in the nucleus; Crf1p 913498 CRF1 851809 CRF1 Saccharomyces cerevisiae Crf1p NP_010509.1 912095 D 4932 CDS NP_010510.1 6320430 851810 complement(914313..914708) 1 NC_001136.8 One of two nearly identical (see HTB2) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation; Htb1p 914708 HTB1 851810 HTB1 Saccharomyces cerevisiae Htb1p NP_010510.1 914313 R 4932 CDS NP_010511.1 6320431 851811 915526..915924 1 NC_001136.8 One of two nearly identical (see also HTA2) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p; Hta1p 915924 HTA1 851811 HTA1 Saccharomyces cerevisiae Hta1p NP_010511.1 915526 D 4932 CDS NP_010512.1 6320432 851812 916482..917150 1 NC_001136.8 Adk1p; Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence 917150 ADK1 851812 ADK1 Saccharomyces cerevisiae Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence NP_010512.1 916482 D 4932 CDS NP_010513.1 6320433 851813 917567..921643 1 NC_001136.8 Sir4p; Silent information regulator that, together with SIR2 and SIR3, is involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; potentially phosphorylated by Cdc28p; some alleles of SIR4 prolong lifespan 921643 SIR4 851813 SIR4 Saccharomyces cerevisiae Silent information regulator that, together with SIR2 and SIR3, is involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; potentially phosphorylated by Cdc28p; some alleles of SIR4 prolong lifespan NP_010513.1 917567 D 4932 CDS NP_010514.1 6320434 851814 complement(921922..923802) 1 NC_001136.8 mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p); Pcf11p 923802 PCF11 851814 PCF11 Saccharomyces cerevisiae Pcf11p NP_010514.1 921922 R 4932 CDS NP_010515.1 6320435 851815 924781..926142 1 NC_001136.8 Phospholipid-binding protein that interacts with both Ypt7p and Vps33p, may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells approach stationary phase; Ivy1p 926142 IVY1 851815 IVY1 Saccharomyces cerevisiae Ivy1p NP_010515.1 924781 D 4932 CDS NP_010517.1 6320437 851817 complement(926289..926906) 1 NC_001136.8 Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase; Cox20p 926906 COX20 851817 COX20 Saccharomyces cerevisiae Cox20p NP_010517.1 926289 R 4932 CDS NP_010518.1 6320438 851818 927448..929094 1 NC_001136.8 Hem1p; 5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p 929094 HEM1 851818 HEM1 Saccharomyces cerevisiae 5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p NP_010518.1 927448 D 4932 CDS NP_010519.1 6320439 851819 complement(929466..930353) 1 NC_001136.8 Rtn1p; ER membrane protein that interacts with exocyst subunit Sec6p and with Yip3p; also interacts with Sbh1p; null mutant has an altered (mostly cisternal) ER morphology; member of the RTNLA (reticulon-like A) subfamily 930353 RTN1 851819 RTN1 Saccharomyces cerevisiae ER membrane protein that interacts with exocyst subunit Sec6p and with Yip3p; also interacts with Sbh1p; null mutant has an altered (mostly cisternal) ER morphology; member of the RTNLA (reticulon-like A) subfamily NP_010519.1 929466 R 4932 CDS NP_010520.1 6320440 851820 931125..933206 1 NC_001136.8 Lys4p; Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway 933206 LYS4 851820 LYS4 Saccharomyces cerevisiae Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway NP_010520.1 931125 D 4932 CDS NP_010521.1 6320441 851821 933500..935134 1 NC_001136.8 U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats; Prp42p 935134 PRP42 851821 PRP42 Saccharomyces cerevisiae Prp42p NP_010521.1 933500 D 4932 CDS NP_010522.1 6320442 851822 complement(935232..935888) 1 NC_001136.8 Riboflavin kinase, phosphorylates riboflavin to form riboflavin monophosphate (FMN), which is a necessary cofactor for many enzymes; localizes to microsomes and to the mitochondrial inner membrane; Fmn1p 935888 FMN1 851822 FMN1 Saccharomyces cerevisiae Fmn1p NP_010522.1 935232 R 4932 CDS NP_010523.1 6320443 851823 936611..937489 1 NC_001136.8 Mrpl7p; Mitochondrial ribosomal protein of the large subunit 937489 MRPL7 851823 MRPL7 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit NP_010523.1 936611 D 4932 CDS NP_010524.1 6320444 851824 complement(937891..940812) 1 NC_001136.8 Sec26p; Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP) 940812 SEC26 851824 SEC26 Saccharomyces cerevisiae Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP) NP_010524.1 937891 R 4932 CDS NP_010525.1 6320445 851825 complement(941053..943416) 1 NC_001136.8 Ydr239cp; Protein of unknown function that may interact with ribosomes, based on co-purification experiments 943416 851825 YDR239C Saccharomyces cerevisiae Protein of unknown function that may interact with ribosomes, based on co-purification experiments NP_010525.1 941053 R 4932 CDS NP_010526.1 6320447 851827 complement(943670..945148) 1 NC_001136.8 Snu56p; Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex 945148 SNU56 851827 SNU56 Saccharomyces cerevisiae Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex NP_010526.1 943670 R 4932 CDS NP_010528.1 6320448 851829 946803..948452 1 NC_001136.8 Putative amidase; Amd2p 948452 AMD2 851829 AMD2 Saccharomyces cerevisiae Amd2p NP_010528.1 946803 D 4932 CDS NP_010529.1 6320449 851830 complement(948514..950280) 1 NC_001136.8 RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site; Prp28p 950280 PRP28 851830 PRP28 Saccharomyces cerevisiae Prp28p NP_010529.1 948514 R 4932 CDS NP_010530.1 6320450 851831 950559..952397 1 NC_001136.8 Pex5p; Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions 952397 PEX5 851831 PEX5 Saccharomyces cerevisiae Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions NP_010530.1 950559 D 4932 CDS NP_010531.1 6320451 851832 952796..953977 1 NC_001136.8 Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family; Mnn10p 953977 MNN10 851832 MNN10 Saccharomyces cerevisiae Mnn10p NP_010531.1 952796 D 4932 CDS NP_010532.1 6320452 851833 954284..954943 1 NC_001136.8 Trs23p; One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; human homolog is TRAPPC4 954943 TRS23 851833 TRS23 Saccharomyces cerevisiae One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; human homolog is TRAPPC4 NP_010532.1 954284 D 4932 CDS NP_878065.1 33438783 1466436 955129..955329 1 NC_001136.8 Ydr246w-ap; Putative protein of unknown function; identified by fungal homology and RT-PCR 955329 1466436 YDR246W-A Saccharomyces cerevisiae Putative protein of unknown function; identified by fungal homology and RT-PCR NP_878065.1 955129 D 4932 CDS NP_010533.1 6320453 851834 956009..957394 1 NC_001136.8 Vhs1p; Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p 957394 VHS1 851834 VHS1 Saccharomyces cerevisiae Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p NP_010533.1 956009 D 4932 CDS NP_010534.1 6320454 851835 complement(957754..958335) 1 NC_001136.8 Ydr248cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 958335 851835 YDR248C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm NP_010534.1 957754 R 4932 CDS NP_010535.1 6320455 851836 complement(958677..959798) 1 NC_001136.8 Ydr249cp; Putative protein of unknown function 959798 851836 YDR249C Saccharomyces cerevisiae Putative protein of unknown function NP_010535.1 958677 R 4932 CDS NP_010537.1 6320457 851838 960610..963102 1 NC_001136.8 Pam1p; Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype 963102 PAM1 851838 PAM1 Saccharomyces cerevisiae Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype NP_010537.1 960610 D 4932 CDS NP_010538.1 6320458 851839 963408..963857 1 NC_001136.8 Btt1p; Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex (alpha, beta1, beta3) which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides 963857 BTT1 851839 BTT1 Saccharomyces cerevisiae Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex (alpha, beta1, beta3) which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides NP_010538.1 963408 D 4932 CDS NP_010539.1 6320459 851840 complement(963986..964561) 1 NC_001136.8 Zinc-finger DNA-binding protein, involved in transcriptional regulation of the methionine biosynthetic genes, similar to Met31p; Met32p 964561 MET32 851840 MET32 Saccharomyces cerevisiae Met32p NP_010539.1 963986 R 4932 CDS NP_010540.1 6320460 851841 965109..966485 1 NC_001136.8 Outer kinetochore protein required for chromosome stability, interacts with kinetochore proteins Ctf19p, Ctf3p, and Iml3p; exhibits a two-hybrid interaction with Mif2p; association with CEN DNA requires Ctf19p; Chl4p 966485 CHL4 851841 CHL4 Saccharomyces cerevisiae Chl4p NP_010540.1 965109 D 4932 CDS NP_010541.1 6320461 851842 complement(966553..967818) 1 NC_001136.8 Rmd5p; Cytosolic protein required for sporulation; also required for the ubiquitination of the gluconeogenetic enzyme fructose-1,6-bisphosphatase, which is degraded rapidly after the switch from gluconeogenesis to glycolysis 967818 RMD5 851842 RMD5 Saccharomyces cerevisiae Cytosolic protein required for sporulation; also required for the ubiquitination of the gluconeogenetic enzyme fructose-1,6-bisphosphatase, which is degraded rapidly after the switch from gluconeogenesis to glycolysis NP_010541.1 966553 R 4932 CDS NP_010542.1 6320462 851843 complement(968129..969676) 1 NC_001136.8 Cta1p; Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation 969676 CTA1 851843 CTA1 Saccharomyces cerevisiae Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation NP_010542.1 968129 R 4932 CDS NP_010543.1 6320463 851844 complement(969986..971470) 1 NC_001136.8 Set7p; Nuclear protein that contains a SET-domain, which have been shown to mediate methyltransferase activity in other proteins 971470 SET7 851844 SET7 Saccharomyces cerevisiae Nuclear protein that contains a SET-domain, which have been shown to mediate methyltransferase activity in other proteins NP_010543.1 969986 R 4932 CDS NP_010544.1 6320464 851845 complement(971804..974239) 1 NC_001136.8 Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; prevents the aggregation of misfolded matrix proteins; component of the mitochondrial proteolysis system; Hsp78p 974239 HSP78 851845 HSP78 Saccharomyces cerevisiae Hsp78p NP_010544.1 971804 R 4932 CDS NP_010545.1 6320465 851846 complement(974627..975778) 1 NC_001136.8 Yap6p; Putative basic leucine zipper (bZIP) transcription factor; overexpression increases sodium and lithium tolerance 975778 YAP6 851846 YAP6 Saccharomyces cerevisiae Putative basic leucine zipper (bZIP) transcription factor; overexpression increases sodium and lithium tolerance NP_010545.1 974627 R 4932 CDS NP_010546.1 6320466 851847 complement(976713..977225) 1 NC_001136.8 Swm1p; Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation 977225 SWM1 851847 SWM1 Saccharomyces cerevisiae Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation NP_010546.1 976713 R 4932 CDS NP_010547.1 6320467 851848 complement(977517..979205) 1 NC_001136.8 Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor; Exg2p 979205 EXG2 851848 EXG2 Saccharomyces cerevisiae Exg2p NP_010547.1 977517 R 4932 CDS NP_058146.1 7839158 851851 join(981458..982750,982752..986771) 1 NC_001136.8 Ydr261w-bp; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 986771 851851 YDR261W-B Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_058146.1 981458 D 4932 CDS NP_058147.1 7839157 851850 981458..982774 1 NC_001136.8 Ydr261w-ap; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 982774 851850 YDR261W-A Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_058147.1 981458 D 4932 CDS NP_058148.1 7839160 851852 complement(join(987530..991039,991041..992345)) 1 NC_001136.8 Ydr261c-dp; Retrotransposon TYA Gag and TYB Pol genes; in YDRCTY1-3 TYB is mutant and probably non-functional 992345 851852 YDR261C-D Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; in YDRCTY1-3 TYB is mutant and probably non-functional NP_058148.1 987530 R 4932 CDS NP_058149.1 7839159 851853 complement(991023..992345) 1 NC_001136.8 Ydr261c-cp; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; in YDRCTY1-3 TYB is mutant and probably non-functional 992345 851853 YDR261C-C Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; in YDRCTY1-3 TYB is mutant and probably non-functional NP_058149.1 991023 R 4932 CDS NP_010548.1 6320468 851855 993130..993948 1 NC_001136.8 Ydr262wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment 993948 851855 YDR262W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment NP_010548.1 993130 D 4932 CDS NP_010549.1 6320469 851856 complement(994238..995530) 1 NC_001136.8 Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination; Din7p 995530 DIN7 851856 DIN7 Saccharomyces cerevisiae Din7p NP_010549.1 994238 R 4932 CDS NP_010550.1 6320470 851857 complement(996025..998319) 1 NC_001136.8 Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; Akr1p 998319 AKR1 851857 AKR1 Saccharomyces cerevisiae Akr1p NP_010550.1 996025 R 4932 CDS NP_010551.1 6320471 851858 998860..999873 1 NC_001136.8 Pex10p; C3HC4-type RING-finger peroxisomal membrane peroxin required for peroxisomal matrix protein import, interacts with Pex12p, links ubiquitin-conjugating Pex4p to import machinery; mutations in human homolog cause various peroxisomal disorders 999873 PEX10 851858 PEX10 Saccharomyces cerevisiae C3HC4-type RING-finger peroxisomal membrane peroxin required for peroxisomal matrix protein import, interacts with Pex12p, links ubiquitin-conjugating Pex4p to import machinery; mutations in human homolog cause various peroxisomal disorders NP_010551.1 998860 D 4932 CDS NP_010552.1 6320472 851859 complement(1000100..1002019) 1 NC_001136.8 Ydr266cp; Protein of unknown function that may interact with ribosomes, based on co-purification experiments;green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; contains a RING finger domain 1002019 851859 YDR266C Saccharomyces cerevisiae Protein of unknown function that may interact with ribosomes, based on co-purification experiments;green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; contains a RING finger domain NP_010552.1 1000100 R 4932 CDS NP_010553.1 6320473 851860 complement(1002506..1003498) 1 NC_001136.8 Essential protein involved in assembly of cytosolic and nuclear iron-sulfur proteins; Cia1p 1003498 CIA1 851860 CIA1 Saccharomyces cerevisiae Cia1p NP_010553.1 1002506 R 4932 CDS NP_010554.1 6320474 851861 1004000..1005139 1 NC_001136.8 Msw1p; Mitochondrial tryptophanyl-tRNA synthetase 1005139 MSW1 851861 MSW1 Saccharomyces cerevisiae Mitochondrial tryptophanyl-tRNA synthetase NP_010554.1 1004000 D 4932 CDS NP_010556.1 6320475 851862 1005671..1008685 1 NC_001136.8 Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; Ccc2p 1008685 CCC2 851862 CCC2 Saccharomyces cerevisiae Ccc2p NP_010556.1 1005671 D 4932 CDS NP_010558.1 6320478 851865 1009006..1009830 1 NC_001136.8 Glo2p; Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate 1009830 GLO2 851865 GLO2 Saccharomyces cerevisiae Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate NP_010558.1 1009006 D 4932 CDS NP_010559.1 6320479 851866 1010172..1011269 1 NC_001136.8 Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II; Don1p 1011269 DON1 851866 DON1 Saccharomyces cerevisiae Don1p NP_010559.1 1010172 D 4932 CDS NP_010561.1 6320481 851868 1012248..1012955 1 NC_001136.8 Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; Bsc2p 1012955 BSC2 851868 BSC2 Saccharomyces cerevisiae Bsc2p NP_010561.1 1012248 D 4932 CDS NP_010562.1 6320482 851869 complement(1013472..1013639) 1 NC_001136.8 Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential; Pmp3p 1013639 PMP3 851869 PMP3 Saccharomyces cerevisiae Pmp3p NP_010562.1 1013472 R 4932 CDS NP_010563.1 6320483 851870 complement(1014397..1015698) 1 NC_001136.8 Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation; Mth1p 1015698 MTH1 851870 MTH1 Saccharomyces cerevisiae Mth1p NP_010563.1 1014397 R 4932 CDS NP_010565.1 6320485 851873 1019364..1020416 1 NC_001136.8 Rnh202p; Ribonuclease H2 subunit, required for RNase H2 activity 1020416 RNH202 851873 RNH202 Saccharomyces cerevisiae Ribonuclease H2 subunit, required for RNase H2 activity NP_010565.1 1019364 D 4932 CDS NP_010566.1 6320486 851874 1020743..1021660 1 NC_001136.8 Rrp45p; Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex 1021660 RRP45 851874 RRP45 Saccharomyces cerevisiae Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex NP_010566.1 1020743 D 4932 CDS NP_010567.1 6320487 851875 complement(1022003..1022317) 1 NC_001136.8 Protein of unknown function, expression is regulated by phosphate levels; Phm6p 1022317 PHM6 851875 PHM6 Saccharomyces cerevisiae Phm6p NP_010567.1 1022003 R 4932 CDS NP_010568.1 6320488 851876 complement(1023507..1024751) 1 NC_001136.8 Ydr282cp; Putative protein of unknown function 1024751 851876 YDR282C Saccharomyces cerevisiae Putative protein of unknown function NP_010568.1 1023507 R 4932 CDS NP_010569.1 6320489 851877 complement(1025066..1030045) 1 NC_001136.8 Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; Gcn2p 1030045 GCN2 851877 GCN2 Saccharomyces cerevisiae Gcn2p NP_010569.1 1025066 R 4932 CDS NP_010570.1 6320490 851878 complement(1030546..1031415) 1 NC_001136.8 Dpp1p; Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism 1031415 DPP1 851878 DPP1 Saccharomyces cerevisiae Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism NP_010570.1 1030546 R 4932 CDS NP_010571.1 6320491 851879 1032432..1035059 1 NC_001136.8 Zip1p; Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrate 1035059 ZIP1 851879 ZIP1 Saccharomyces cerevisiae Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrate NP_010571.1 1032432 D 4932 CDS NP_010572.1 6320492 851880 complement(1035227..1035571) 1 NC_001136.8 Ydr286cp; Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site 1035571 851880 YDR286C Saccharomyces cerevisiae Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site NP_010572.1 1035227 R 4932 CDS NP_010573.1 6320493 851881 1035991..1036869 1 NC_001136.8 Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy; Inm2p 1036869 INM2 851881 INM2 Saccharomyces cerevisiae Inm2p NP_010573.1 1035991 D 4932 CDS NP_010574.1 6320494 851882 1037191..1038102 1 NC_001136.8 Nse3p; Essential subunit of the Mms21-Smc5-Smc6 complex; protein of unknown function; required for DNA repair and growth 1038102 NSE3 851882 NSE3 Saccharomyces cerevisiae Essential subunit of the Mms21-Smc5-Smc6 complex; protein of unknown function; required for DNA repair and growth NP_010574.1 1037191 D 4932 CDS NP_010575.1 6320496 851884 complement(1038276..1039505) 1 NC_001136.8 Rtt103p; Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition 1039505 RTT103 851884 RTT103 Saccharomyces cerevisiae Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition NP_010575.1 1038276 R 4932 CDS NP_010577.1 6320497 851885 1039724..1042957 1 NC_001136.8 Putative DNA helicase; Hrq1p 1042957 HRQ1 851885 HRQ1 Saccharomyces cerevisiae Hrq1p NP_010577.1 1039724 D 4932 CDS NP_010578.1 6320498 851886 complement(1043142..1045007) 1 NC_001136.8 Srp101p; Signal recognition particle (SRP) receptor - alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with SRP102p 1045007 SRP101 851886 SRP101 Saccharomyces cerevisiae Signal recognition particle (SRP) receptor - alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with SRP102p NP_010578.1 1043142 R 4932 CDS NP_010579.1 6320499 851887 complement(1045636..1049388) 1 NC_001136.8 Ssd1p; Protein with a role in maintenance of cellular integrity, interacts with components of the TOR pathway; ssd1 mutant of a clinical S. cerevisiae strain displays elevated virulence 1049388 SSD1 851887 SSD1 Saccharomyces cerevisiae Protein with a role in maintenance of cellular integrity, interacts with components of the TOR pathway; ssd1 mutant of a clinical S. cerevisiae strain displays elevated virulence NP_010579.1 1045636 R 4932 CDS NP_010580.1 6320500 851888 complement(1050455..1052224) 1 NC_001136.8 Dpl1p; Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate 1052224 DPL1 851888 DPL1 Saccharomyces cerevisiae Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate NP_010580.1 1050455 R 4932 CDS NP_010581.1 6320501 851889 complement(1052619..1054643) 1 NC_001136.8 Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance; Hda2p 1054643 HDA2 851889 HDA2 Saccharomyces cerevisiae Hda2p NP_010581.1 1052619 R 4932 CDS NP_010582.1 6320502 851890 1055208..1055888 1 NC_001136.8 Protein involved in homologous recombination in mitochondria and in transcription regulation in nucleus; binds to activation domains of acidic activators; required for recombination-dependent mtDNA partitioning; Mhr1p 1055888 MHR1 851890 MHR1 Saccharomyces cerevisiae Mhr1p NP_010582.1 1055208 D 4932 CDS NP_010583.1 6320503 851891 1056547..1057596 1 NC_001136.8 Sur2p; Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis 1057596 SUR2 851891 SUR2 Saccharomyces cerevisiae Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis NP_010583.1 1056547 D 4932 CDS NP_010584.1 6320504 851892 complement(1058172..1058810) 1 NC_001136.8 Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated; Atp5p 1058810 ATP5 851892 ATP5 Saccharomyces cerevisiae Atp5p NP_010584.1 1058172 R 4932 CDS NP_010585.1 6320505 851893 1059623..1061227 1 NC_001136.8 Essential protein possibly involved in secretion; multicopy suppressor of sensitivity to Brefeldin A; Bfr2p 1061227 BFR2 851893 BFR2 Saccharomyces cerevisiae Bfr2p NP_010585.1 1059623 D 4932 CDS NP_010586.1 6320506 851894 complement(1061501..1062787) 1 NC_001136.8 Pro1p; Gamma-glutamyl kinase, catalyzes the first step in proline biosynthesis 1062787 PRO1 851894 PRO1 Saccharomyces cerevisiae Gamma-glutamyl kinase, catalyzes the first step in proline biosynthesis NP_010586.1 1061501 R 4932 CDS NP_010587.1 6320507 851895 1063348..1067421 1 NC_001136.8 RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF; Cft1p 1067421 CFT1 851895 CFT1 Saccharomyces cerevisiae Cft1p NP_010587.1 1063348 D 4932 CDS NP_010588.1 6320508 851896 1067727..1068386 1 NC_001136.8 Gpi11p; ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog 1068386 GPI11 851896 GPI11 Saccharomyces cerevisiae ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog NP_010588.1 1067727 D 4932 CDS NP_010589.1 6320509 851897 complement(1068725..1071382) 1 NC_001136.8 Rsc3p; Component of the RSC chromatin remodeling complex; essential gene required for maintenance of proper ploidy and regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc30p 1071382 RSC3 851897 RSC3 Saccharomyces cerevisiae Component of the RSC chromatin remodeling complex; essential gene required for maintenance of proper ploidy and regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc30p NP_010589.1 1068725 R 4932 CDS NP_010590.1 6320510 851898 complement(1071876..1072553) 1 NC_001136.8 Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER; Cpr5p 1072553 CPR5 851898 CPR5 Saccharomyces cerevisiae Cpr5p NP_010590.1 1071876 R 4932 CDS NP_010591.1 6320511 851899 complement(join(1072742..1073308,1073398..1073484)) 1 NC_001136.8 Hnt2p; Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins 1073484 HNT2 851899 HNT2 Saccharomyces cerevisiae Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins NP_010591.1 1072742 R 4932 CDS NP_010592.1 6320512 851900 complement(1073731..1075167) 1 NC_001136.8 Ydr306cp; F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain 1075167 851900 YDR306C Saccharomyces cerevisiae F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain NP_010592.1 1073731 R 4932 CDS NP_010593.1 6320513 851902 1075861..1077849 1 NC_001136.8 Ydr307wp; Putative protein of unknown function 1077849 851902 YDR307W Saccharomyces cerevisiae Putative protein of unknown function NP_010593.1 1075861 D 4932 CDS NP_010594.1 6320514 851903 complement(1078023..1078445) 1 NC_001136.8 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p; Srb7p 1078445 SRB7 851903 SRB7 Saccharomyces cerevisiae Srb7p NP_010594.1 1078023 R 4932 CDS NP_010595.1 6320515 851904 complement(1079044..1080195) 1 NC_001136.8 Protein of unknown function involved in initiation of budding and cellular polarization, interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain; Gic2p 1080195 GIC2 851904 GIC2 Saccharomyces cerevisiae Gic2p NP_010595.1 1079044 R 4932 CDS NP_010596.1 6320516 851905 complement(1081124..1084312) 1 NC_001136.8 Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; involved in telomere maintenance, regulated by the pachytene checkpoint; Sum1p 1084312 SUM1 851905 SUM1 Saccharomyces cerevisiae Sum1p NP_010596.1 1081124 R 4932 CDS NP_010597.1 6320517 851906 1085062..1086990 1 NC_001136.8 Tfb1p; Subunit of TFIIH and nucleotide excision repair factor 3 complexes, required for nucleotide excision repair, target for transcriptional activators 1086990 TFB1 851906 TFB1 Saccharomyces cerevisiae Subunit of TFIIH and nucleotide excision repair factor 3 complexes, required for nucleotide excision repair, target for transcriptional activators NP_010597.1 1085062 D 4932 CDS NP_010598.1 6320518 851907 1087578..1088939 1 NC_001136.8 Ssf2p; Protein required for ribosomal large subunit maturation, functionally redundant with Ssf1p; member of the Brix family 1088939 SSF2 851907 SSF2 Saccharomyces cerevisiae Protein required for ribosomal large subunit maturation, functionally redundant with Ssf1p; member of the Brix family NP_010598.1 1087578 D 4932 CDS NP_010599.1 6320519 851908 complement(1089216..1090076) 1 NC_001136.8 RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain; Pib1p 1090076 PIB1 851908 PIB1 Saccharomyces cerevisiae Pib1p NP_010599.1 1089216 R 4932 CDS NP_010600.1 6320520 851909 complement(1090430..1092508) 1 NC_001136.8 Rad34p; Protein involved in nucleotide excision repair (NER); homologous to RAD4 1092508 RAD34 851909 RAD34 Saccharomyces cerevisiae Protein involved in nucleotide excision repair (NER); homologous to RAD4 NP_010600.1 1090430 R 4932 CDS NP_010601.1 6320521 851910 complement(1092738..1093583) 1 NC_001136.8 Ipk1p; Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable 1093583 IPK1 851910 IPK1 Saccharomyces cerevisiae Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable NP_010601.1 1092738 R 4932 CDS NP_010602.1 6320522 851911 1093760..1095175 1 NC_001136.8 Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations; Oms1p 1095175 OMS1 851911 OMS1 Saccharomyces cerevisiae Oms1p NP_010602.1 1093760 D 4932 CDS NP_058150.1 7839162 851914 join(1096061..1097365,1097367..1101329) 1 NC_001136.8 Ydr316w-bp; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 1101329 851914 YDR316W-B Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_058150.1 1096061 D 4932 CDS NP_058151.1 7839161 851913 1096061..1097383 1 NC_001136.8 Ydr316w-ap; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 1097383 851913 YDR316W-A Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_058151.1 1096061 D 4932 CDS NP_010603.1 6320523 851915 1102181..1103425 1 NC_001136.8 Protein of unknown function involved in DNA repair; Him1p 1103425 HIM1 851915 HIM1 Saccharomyces cerevisiae Him1p NP_010603.1 1102181 D 4932 CDS NP_010604.2 37362633 851916 join(1103755..1103806,1103890..1104944) 1 NC_001136.8 Protein involved in minichromosome maintenance; component of the COMA complex (Ctf19p, Okp1p, Mcm21p, Ame1p) that bridges kinetochore subunits that are in contact with centromeric DNA and the subunits bound to microtubules; Mcm21p 1104944 MCM21 851916 MCM21 Saccharomyces cerevisiae Mcm21p NP_010604.2 1103755 D 4932 CDS NP_010605.1 6320525 851917 complement(1105000..1105824) 1 NC_001136.8 Yft2p; Putative protein of unknown function, identified as an ortholog of the highly conserved FIT family of proteins involved in triglyceride droplet biosynthesis; interacts with Sst2p and Hsp82p in high-throughput two-hybrid screens 1105824 YFT2 851917 YFT2 Saccharomyces cerevisiae Putative protein of unknown function, identified as an ortholog of the highly conserved FIT family of proteins involved in triglyceride droplet biosynthesis; interacts with Sst2p and Hsp82p in high-throughput two-hybrid screens NP_010605.1 1105000 R 4932 CDS NP_010606.1 6320526 851918 complement(1106092..1108098) 1 NC_001136.8 Swa2p; Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles 1108098 SWA2 851918 SWA2 Saccharomyces cerevisiae Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles NP_010606.1 1106092 R 4932 CDS NP_710144.1 24416034 851919 complement(1108277..1108495) 1 NC_001136.8 Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis; Dad4p 1108495 DAD4 851919 DAD4 Saccharomyces cerevisiae Dad4p NP_710144.1 1108277 R 4932 CDS NP_010607.1 6320527 851920 1108699..1109844 1 NC_001136.8 Cytosolic L-asparaginase, involved in asparagine catabolism; Asp1p 1109844 ASP1 851920 ASP1 Saccharomyces cerevisiae Asp1p NP_010607.1 1108699 D 4932 CDS NP_010608.1 6320528 851921 1110586..1111689 1 NC_001136.8 Mrpl35p; Mitochondrial ribosomal protein of the large subunit 1111689 MRPL35 851921 MRPL35 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit NP_010608.1 1110586 D 4932 CDS NP_010609.1 6320529 851922 complement(1112000..1112290) 1 NC_001136.8 Tim11p; Subunit e of mitochondrial F1F0-ATPase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric and oligomeric state of ATP synthase 1112290 TIM11 851922 TIM11 Saccharomyces cerevisiae Subunit e of mitochondrial F1F0-ATPase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric and oligomeric state of ATP synthase NP_010609.1 1112000 R 4932 CDS NP_010610.1 6320530 851923 complement(1112477..1114024) 1 NC_001136.8 Pep7p; Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance 1114024 PEP7 851923 PEP7 Saccharomyces cerevisiae Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance NP_010610.1 1112477 R 4932 CDS NP_010611.1 6320531 851924 complement(1114430..1116760) 1 NC_001136.8 Utp4p; Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA 1116760 UTP4 851924 UTP4 Saccharomyces cerevisiae Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA NP_010611.1 1114430 R 4932 CDS NP_010612.2 27469361 851925 1117121..1120228 1 NC_001136.8 Ycg1p; Non-SMC subunit of the condensin complex (Smc2p-Smc4p-Ycs4p-Brn1p-Ycg1p); required for establishment and maintenance of chromosome condensation, chromosome segregation and for chromatin binding of the condensin complex 1120228 YCG1 851925 YCG1 Saccharomyces cerevisiae Non-SMC subunit of the condensin complex (Smc2p-Smc4p-Ycs4p-Brn1p-Ycg1p); required for establishment and maintenance of chromosome condensation, chromosome segregation and for chromatin binding of the condensin complex NP_010612.2 1117121 D 4932 CDS NP_010613.1 6320533 851926 complement(1120604..1124920) 1 NC_001136.8 Ysp2p; Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification 1124920 YSP2 851926 YSP2 Saccharomyces cerevisiae Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification NP_010613.1 1120604 R 4932 CDS NP_010615.1 6320535 851928 complement(1125429..1126013) 1 NC_001136.8 Skp1p; Evolutionarily conserved kinetochore protein that is part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase 1126013 SKP1 851928 SKP1 Saccharomyces cerevisiae Evolutionarily conserved kinetochore protein that is part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase NP_010615.1 1125429 R 4932 CDS NP_010616.1 6320536 851929 complement(1126265..1127590) 1 NC_001136.8 Pex3p; Peroxisomal membrane protein (PMP) required required for the proper localization and stability of PMPs; interacts with Pex19p 1127590 PEX3 851929 PEX3 Saccharomyces cerevisiae Peroxisomal membrane protein (PMP) required required for the proper localization and stability of PMPs; interacts with Pex19p NP_010616.1 1126265 R 4932 CDS NP_010617.1 6320537 851930 1127867..1129369 1 NC_001136.8 Ubx5p; UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p 1129369 UBX5 851930 UBX5 Saccharomyces cerevisiae UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p NP_010617.1 1127867 D 4932 CDS NP_010618.1 6320538 851931 1129583..1130818 1 NC_001136.8 Gpi8p; ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog 1130818 GPI8 851931 GPI8 Saccharomyces cerevisiae ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog NP_010618.1 1129583 D 4932 CDS NP_010619.1 6320539 851932 1130996..1133065 1 NC_001136.8 hypothetical protein; null mutant displays increased levels of spontaneous Rad52 foci; Irc3p 1133065 IRC3 851932 IRC3 Saccharomyces cerevisiae Irc3p NP_010619.1 1130996 D 4932 CDS NP_010620.1 6320540 851933 complement(1133255..1135426) 1 NC_001136.8 Ydr333cp; Putative protein of unknown function 1135426 851933 YDR333C Saccharomyces cerevisiae Putative protein of unknown function NP_010620.1 1133255 R 4932 CDS NP_010621.1 6320541 851934 1135927..1140471 1 NC_001136.8 Swr1p; Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A 1140471 SWR1 851934 SWR1 Saccharomyces cerevisiae Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A NP_010621.1 1135927 D 4932 CDS NP_010622.1 6320542 851935 1141162..1144836 1 NC_001136.8 Msn5p; Karyopherin involved in nuclear import and export; shown to be responsible for nuclear import of replication protein A and for export of several proteins including Swi6p, Far1p, and Pho4p; cargo dissociation involves binding to RanGTP 1144836 MSN5 851935 MSN5 Saccharomyces cerevisiae Karyopherin involved in nuclear import and export; shown to be responsible for nuclear import of replication protein A and for export of several proteins including Swi6p, Far1p, and Pho4p; cargo dissociation involves binding to RanGTP NP_010622.1 1141162 D 4932 CDS NP_010623.1 6320543 851936 1145086..1146030 1 NC_001136.8 Ydr336wp; Putative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene 1146030 851936 YDR336W Saccharomyces cerevisiae Putative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene NP_010623.1 1145086 D 4932 CDS NP_010624.1 6320544 851937 1146313..1147173 1 NC_001136.8 Mrps28p; Mitochondrial ribosomal protein of the small subunit 1147173 MRPS28 851937 MRPS28 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the small subunit NP_010624.1 1146313 D 4932 CDS NP_010625.1 6320545 851938 complement(1147373..1149460) 1 NC_001136.8 Ydr338cp 1149460 851938 YDR338C Saccharomyces cerevisiae Ydr338cp NP_010625.1 1147373 R 4932 CDS NP_010626.1 6320546 851939 complement(1149945..1150514) 1 NC_001136.8 Fcf1p; Essential nucleolar protein that is a component of the SSU (small subunit) processome involved in the pre-rRNA processing steps of 40S ribosomal subunit biogenesis; contains a PINc domain; copurifies with Faf1p 1150514 FCF1 851939 FCF1 Saccharomyces cerevisiae Essential nucleolar protein that is a component of the SSU (small subunit) processome involved in the pre-rRNA processing steps of 40S ribosomal subunit biogenesis; contains a PINc domain; copurifies with Faf1p NP_010626.1 1149945 R 4932 CDS NP_010628.1 6320548 851942 complement(1151797..1153620) 1 NC_001136.8 Ydr341cp; Arginyl-tRNA synthetase, proposed to be cytoplasmic but the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 1153620 851942 YDR341C Saccharomyces cerevisiae Arginyl-tRNA synthetase, proposed to be cytoplasmic but the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_010628.1 1151797 R 4932 CDS NP_010629.1 6320549 851943 complement(1154210..1155922) 1 NC_001136.8 Hxt7p; High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels 1155922 HXT7 851943 HXT7 Saccharomyces cerevisiae High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels NP_010629.1 1154210 R 4932 CDS NP_010630.1 6320550 851944 complement(1159602..1161314) 1 NC_001136.8 Hxt6p; High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3 1161314 HXT6 851944 HXT6 Saccharomyces cerevisiae High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3 NP_010630.1 1159602 R 4932 CDS NP_010632.1 6320552 851946 complement(1162951..1164654) 1 NC_001136.8 Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions; Hxt3p 1164654 HXT3 851946 HXT3 Saccharomyces cerevisiae Hxt3p NP_010632.1 1162951 R 4932 CDS NP_010633.1 6320553 851947 complement(1167208..1168653) 1 NC_001136.8 Svf1p; Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis 1168653 SVF1 851947 SVF1 Saccharomyces cerevisiae Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis NP_010633.1 1167208 R 4932 CDS NP_010634.1 6320554 851948 1169172..1170137 1 NC_001136.8 Mrp1p; Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein 1170137 MRP1 851948 MRP1 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein NP_010634.1 1169172 D 4932 CDS NP_010635.1 6320555 851949 complement(1170320..1171819) 1 NC_001136.8 Ydr348cp; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud neck; potential Cdc28p substrate 1171819 851949 YDR348C Saccharomyces cerevisiae Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud neck; potential Cdc28p substrate NP_010635.1 1170320 R 4932 CDS NP_010636.1 6320556 851950 complement(1172380..1174170) 1 NC_001136.8 Yps7p; Putative GPI-anchored aspartic protease, located in the cytoplasm and endoplasmic reticulum 1174170 YPS7 851950 YPS7 Saccharomyces cerevisiae Putative GPI-anchored aspartic protease, located in the cytoplasm and endoplasmic reticulum NP_010636.1 1172380 R 4932 CDS NP_010637.1 6320557 851952 complement(1176332..1178167) 1 NC_001136.8 Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; Atp22p 1178167 ATP22 851952 ATP22 Saccharomyces cerevisiae Atp22p NP_010637.1 1176332 R 4932 CDS NP_010638.1 6320558 851953 1178659..1181253 1 NC_001136.8 Sbe2p; Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth 1181253 SBE2 851953 SBE2 Saccharomyces cerevisiae Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth NP_010638.1 1178659 D 4932 CDS NP_010639.1 6320559 851954 1181794..1182747 1 NC_001136.8 Ydr352wp; Putative protein of unknown function 1182747 851954 YDR352W Saccharomyces cerevisiae Putative protein of unknown function NP_010639.1 1181794 D 4932 CDS NP_010640.1 6320560 851955 1183292..1184251 1 NC_001136.8 Trr1p; Cytoplasmic thioredoxin reductase, key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress 1184251 TRR1 851955 TRR1 Saccharomyces cerevisiae Cytoplasmic thioredoxin reductase, key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress NP_010640.1 1183292 D 4932 CDS NP_010641.1 6320561 851956 1184740..1185882 1 NC_001136.8 Trp4p; Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis 1185882 TRP4 851956 TRP4 Saccharomyces cerevisiae Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis NP_010641.1 1184740 D 4932 CDS NP_010643.1 6320562 851957 1186100..1188934 1 NC_001136.8 Spc110p; Inner plaque spindle pole body (SPB) component, ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner 1188934 SPC110 851957 SPC110 Saccharomyces cerevisiae Inner plaque spindle pole body (SPB) component, ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner NP_010643.1 1186100 D 4932 CDS NP_010644.1 6320564 851959 complement(1189192..1189560) 1 NC_001136.8 Ydr357cp; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 1189560 851959 YDR357C Saccharomyces cerevisiae Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern NP_010644.1 1189192 R 4932 CDS NP_010645.1 6320565 851960 1190052..1191725 1 NC_001136.8 Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi; Gga1p 1191725 GGA1 851960 GGA1 Saccharomyces cerevisiae Gga1p NP_010645.1 1190052 D 4932 CDS NP_010646.2 42742058 851962 complement(1191929..1194877) 1 NC_001136.8 Eaf1p; Component of the NuA4 histone acetyltransferase complex 1194877 EAF1 851962 EAF1 Saccharomyces cerevisiae Component of the NuA4 histone acetyltransferase complex NP_010646.2 1191929 R 4932 CDS NP_010648.1 6320568 851963 complement(1195404..1196255) 1 NC_001136.8 Essential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport; Bcp1p 1196255 BCP1 851963 BCP1 Saccharomyces cerevisiae Bcp1p NP_010648.1 1195404 R 4932 CDS NP_010649.1 6320569 851964 complement(1196671..1198689) 1 NC_001136.8 Tfc6p; One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110 1198689 TFC6 851964 TFC6 Saccharomyces cerevisiae One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110 NP_010649.1 1196671 R 4932 CDS NP_010650.1 6320570 851965 1199175..1200545 1 NC_001136.8 Protein involved in mating-type locus silencing, interacts with Sir2p; probably functions to recruit or stabilize Sir proteins; Esc2p 1200545 ESC2 851965 ESC2 Saccharomyces cerevisiae Esc2p NP_010650.1 1199175 D 4932 CDS NP_010651.1 6320571 851967 1202120..1202389 1 NC_001136.8 Sem1p; Component of the lid subcomplex of the regulatory subunit of the 26S proteasome; ortholog of human DSS1 1202389 SEM1 851967 SEM1 Saccharomyces cerevisiae Component of the lid subcomplex of the regulatory subunit of the 26S proteasome; ortholog of human DSS1 NP_010651.1 1202120 D 4932 CDS NP_010652.1 6320572 851968 complement(1202835..1204202) 1 NC_001136.8 Pre-mRNA splicing factor, important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression; required for DNA synthesis during mitosis and meiosis; has WD repeats; Cdc40p 1204202 CDC40 851968 CDC40 Saccharomyces cerevisiae Cdc40p NP_010652.1 1202835 R 4932 CDS NP_010653.1 6320573 851969 complement(1204489..1206375) 1 NC_001136.8 Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels; Esf1p 1206375 ESF1 851969 ESF1 Saccharomyces cerevisiae Esf1p NP_010653.1 1204489 R 4932 CDS NP_058152.1 7839164 851971 join(1206989..1208293,1208295..1212257) 1 NC_001136.8 Ydr365w-bp; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 1212257 851971 YDR365W-B Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_058152.1 1206989 D 4932 CDS NP_058153.1 7839163 851970 1206989..1208311 1 NC_001136.8 Ydr365w-ap; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 1208311 851970 YDR365W-A Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_058153.1 1206989 D 4932 CDS NP_010654.1 6320574 851972 complement(1212430..1212828) 1 NC_001136.8 Ydr366cp 1212828 851972 YDR366C Saccharomyces cerevisiae Ydr366cp NP_010654.1 1212430 R 4932 CDS NP_010655.1 6320575 851973 join(1212840..1212869,1212971..1213606) 1 NC_001136.8 Ydr367wp; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 1213606 851973 YDR367W Saccharomyces cerevisiae Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern NP_010655.1 1212840 D 4932 CDS NP_010656.1 6320576 851974 1213896..1214834 1 NC_001136.8 Ypr1p; 2-methylbutyraldehyde reductase, may be involved in isoleucine catabolism 1214834 YPR1 851974 YPR1 Saccharomyces cerevisiae 2-methylbutyraldehyde reductase, may be involved in isoleucine catabolism NP_010656.1 1213896 D 4932 CDS NP_010657.1 6320577 851975 complement(1215008..1217572) 1 NC_001136.8 Xrs2p; Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling 1217572 XRS2 851975 XRS2 Saccharomyces cerevisiae Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling NP_010657.1 1215008 R 4932 CDS NP_010658.1 6320578 851976 complement(1217774..1219102) 1 NC_001136.8 Ydr370cp; Putative protein of unknown function 1219102 851976 YDR370C Saccharomyces cerevisiae Putative protein of unknown function NP_010658.1 1217774 R 4932 CDS NP_010659.1 6320579 851977 1219405..1220940 1 NC_001136.8 Sporulation-specific chitinase; Cts2p 1220940 CTS2 851977 CTS2 Saccharomyces cerevisiae Cts2p NP_010659.1 1219405 D 4932 CDS NP_010660.1 6320580 851978 complement(1221104..1222141) 1 NC_001136.8 Vps74p; Non-essential protein of unknown function involved in vacuolar protein sorting; belongs to a family of cytosolic Golgi-associated proteins suggesting that it may play a role in secretion; also detected in the nucleus 1222141 VPS74 851978 VPS74 Saccharomyces cerevisiae Non-essential protein of unknown function involved in vacuolar protein sorting; belongs to a family of cytosolic Golgi-associated proteins suggesting that it may play a role in secretion; also detected in the nucleus NP_010660.1 1221104 R 4932 CDS NP_010661.1 6320581 851979 1222751..1223323 1 NC_001136.8 N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily; Frq1p 1223323 FRQ1 851979 FRQ1 Saccharomyces cerevisiae Frq1p NP_010661.1 1222751 D 4932 CDS NP_010662.1 6320582 851980 complement(1223466..1224386) 1 NC_001136.8 Ydr374cp; Putative protein of unknown function 1224386 851980 YDR374C Saccharomyces cerevisiae Putative protein of unknown function NP_010662.1 1223466 R 4932 CDS NP_001032576.1 82795246 3799971 1224749..1225018 1 NC_001136.8 Ydr374w-ap; Putative protein of unknown function 1225018 3799971 YDR374W-A Saccharomyces cerevisiae Putative protein of unknown function NP_001032576.1 1224749 D 4932 CDS NP_010663.1 6320583 851981 complement(1225158..1226528) 1 NC_001136.8 Protein of the mitochondrial inner membrane that functions as an ATP-dependent chaperone, required for the incorporation of the Rip1p and Qcr10p subunits into the cytochrome bc(1) complex; member of the CDC48/PAS1/SEC18 ATPase family; Bcs1p 1226528 BCS1 851981 BCS1 Saccharomyces cerevisiae Bcs1p NP_010663.1 1225158 R 4932 CDS NP_010664.1 6320584 851982 1226814..1228295 1 NC_001136.8 Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability; Arh1p 1228295 ARH1 851982 ARH1 Saccharomyces cerevisiae Arh1p NP_010664.1 1226814 D 4932 CDS NP_010665.1 6320585 851983 1228603..1228908 1 NC_001136.8 Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; Atp17p 1228908 ATP17 851983 ATP17 Saccharomyces cerevisiae Atp17p NP_010665.1 1228603 D 4932 CDS NP_010666.2 82795247 851984 complement(1229341..1229601) 1 NC_001136.8 Lsm6p; Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA 1229601 LSM6 851984 LSM6 Saccharomyces cerevisiae Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA NP_010666.2 1229341 R 4932 CDS NP_010667.1 6320587 851985 1230159..1233188 1 NC_001136.8 Rga2p; GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth 1233188 RGA2 851985 RGA2 Saccharomyces cerevisiae GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth NP_010667.1 1230159 D 4932 CDS NP_076888.1 13129166 851986 complement(1233270..1233509) 1 NC_001136.8 hypothetical protein identified by homology. See FEBS Letters [2000] 487:31-36.; Ydr379c-ap 1233509 851986 YDR379C-A Saccharomyces cerevisiae Ydr379c-ap NP_076888.1 1233270 R 4932 CDS NP_010668.1 6320588 851987 1234210..1236117 1 NC_001136.8 Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway; Aro10p 1236117 ARO10 851987 ARO10 Saccharomyces cerevisiae Aro10p NP_010668.1 1234210 D 4932 CDS NP_010669.1 6320589 851988 join(1236550..1236834,1237601..1237996) 1 NC_001136.8 Yra1p; Nuclear protein that binds to RNA and to Mex67p, required for export of poly(A)+ mRNA from the nucleus; member of the REF (RNA and export factor binding proteins) family; another family member, Yra2p, can substitute for Yra1p function 1237996 YRA1 851988 YRA1 Saccharomyces cerevisiae Nuclear protein that binds to RNA and to Mex67p, required for export of poly(A)+ mRNA from the nucleus; member of the REF (RNA and export factor binding proteins) family; another family member, Yra2p, can substitute for Yra1p function NP_010669.1 1236550 D 4932 CDS NP_219495.2 41629695 851989 complement(join(1238304..1238622,1238817..1238842)) 1 NC_001136.8 Ydr381c-ap; Protein of unknown function, localized to the mitochondrial outer membrane 1238842 851989 YDR381C-A Saccharomyces cerevisiae Protein of unknown function, localized to the mitochondrial outer membrane NP_219495.2 1238304 R 4932 CDS NP_010670.1 6320590 851990 1239484..1239816 1 NC_001136.8 Rpp2bp; Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm 1239816 RPP2B 851990 RPP2B Saccharomyces cerevisiae Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm NP_010670.1 1239484 D 4932 CDS NP_010671.2 37362634 851991 complement(1239952..1240668) 1 NC_001136.8 Non-essential kinetochore protein, subunit of the Ctf19 central kinetochore complex (Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p- Nkp1p-Nkp2p-Ame1p-Mtw1p); Nkp1p 1240668 NKP1 851991 NKP1 Saccharomyces cerevisiae Nkp1p NP_010671.2 1239952 R 4932 CDS NP_010672.1 6320592 851992 complement(1241196..1242023) 1 NC_001136.8 Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters; Ato3p 1242023 ATO3 851992 ATO3 Saccharomyces cerevisiae Ato3p NP_010672.1 1241196 R 4932 CDS NP_010673.1 6320593 851993 1243222..1245750 1 NC_001136.8 Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; Eft2p 1245750 EFT2 851993 EFT2 Saccharomyces cerevisiae Eft2p NP_010673.1 1243222 D 4932 CDS NP_010674.1 6320594 851994 1246076..1247974 1 NC_001136.8 Mus81p; Helix-hairpin-helix protein, involved in DNA repair and replication fork stability; functions as an endonuclease in complex with Mms4p; interacts with Rad54p 1247974 MUS81 851994 MUS81 Saccharomyces cerevisiae Helix-hairpin-helix protein, involved in DNA repair and replication fork stability; functions as an endonuclease in complex with Mms4p; interacts with Rad54p NP_010674.1 1246076 D 4932 CDS NP_010675.1 6320595 851995 complement(1248146..1249813) 1 NC_001136.8 Ydr387cp; Putative transporter, member of the sugar porter family; YDR387C is not an essential gene 1249813 851995 YDR387C Saccharomyces cerevisiae Putative transporter, member of the sugar porter family; YDR387C is not an essential gene NP_010675.1 1248146 R 4932 CDS NP_010676.1 6320596 851996 1250178..1251626 1 NC_001136.8 Rvs167p; Actin-associated protein, subunit of a complex (Rvs161p-Rvs167p) involved in regulation of actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; homolog of mammalian amphiphysin 1251626 RVS167 851996 RVS167 Saccharomyces cerevisiae Actin-associated protein, subunit of a complex (Rvs161p-Rvs167p) involved in regulation of actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; homolog of mammalian amphiphysin NP_010676.1 1250178 D 4932 CDS NP_010677.1 6320597 851997 1252529..1254493 1 NC_001136.8 Sac7p; GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate 1254493 SAC7 851997 SAC7 Saccharomyces cerevisiae GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate NP_010677.1 1252529 D 4932 CDS NP_010678.1 6320598 851998 complement(1254929..1256839) 1 NC_001136.8 Uba2p; Nuclear protein that acts as a heterodimer with Aos1p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability 1256839 UBA2 851998 UBA2 Saccharomyces cerevisiae Nuclear protein that acts as a heterodimer with Aos1p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability NP_010678.1 1254929 R 4932 CDS NP_010679.1 6320599 852000 complement(1257350..1258048) 1 NC_001136.8 Ydr391cp; Putative protein of unknown function, possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus 1258048 852000 YDR391C Saccharomyces cerevisiae Putative protein of unknown function, possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus NP_010679.1 1257350 R 4932 CDS NP_010680.1 6320600 852001 1258688..1259701 1 NC_001136.8 Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters; Spt3p 1259701 SPT3 852001 SPT3 Saccharomyces cerevisiae Spt3p NP_010680.1 1258688 D 4932 CDS NP_010681.1 6320601 852002 1259893..1261263 1 NC_001136.8 She9p; Mitochondrial inner membrane protein required for normal mitochondrial morphology, may be involved in fission of the inner membrane; forms a homo-oligomeric complex 1261263 SHE9 852002 SHE9 Saccharomyces cerevisiae Mitochondrial inner membrane protein required for normal mitochondrial morphology, may be involved in fission of the inner membrane; forms a homo-oligomeric complex NP_010681.1 1259893 D 4932 CDS NP_010682.1 6320602 852003 1261673..1262959 1 NC_001136.8 Rpt3p; One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B 1262959 RPT3 852003 RPT3 Saccharomyces cerevisiae One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B NP_010682.1 1261673 D 4932 CDS NP_010683.1 6320603 852004 1263316..1266150 1 NC_001136.8 Sxm1p; Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1 1266150 SXM1 852004 SXM1 Saccharomyces cerevisiae Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1 NP_010683.1 1263316 D 4932 CDS NP_010685.1 6320605 852006 complement(join(1266358..1266761,1266854..1266890)) 1 NC_001136.8 Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta; Ncb2p 1266890 NCB2 852006 NCB2 Saccharomyces cerevisiae Ncb2p NP_010685.1 1266358 R 4932 CDS NP_010686.1 6320606 852007 1267463..1269394 1 NC_001136.8 Utp5p; Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA 1269394 UTP5 852007 UTP5 Saccharomyces cerevisiae Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA NP_010686.1 1267463 D 4932 CDS NP_010687.1 6320607 852008 1270060..1270725 1 NC_001136.8 Hpt1p; Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine monophosphate and guanosine monophosphate; mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome 1270725 HPT1 852008 HPT1 Saccharomyces cerevisiae Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine monophosphate and guanosine monophosphate; mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome NP_010687.1 1270060 D 4932 CDS NP_010688.2 37362635 852009 1271055..1272077 1 NC_001136.8 Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways; Urh1p 1272077 URH1 852009 URH1 Saccharomyces cerevisiae Urh1p NP_010688.2 1271055 D 4932 CDS NP_010690.1 6320610 852011 complement(1272226..1273695) 1 NC_001136.8 N-formyltyrosine oxidase, sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s; Dit2p 1273695 DIT2 852011 DIT2 Saccharomyces cerevisiae Dit2p NP_010690.1 1272226 R 4932 CDS NP_010691.1 6320611 852012 1274594..1276204 1 NC_001136.8 Sporulation-specific enzyme required for spore wall maturation, involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure; Dit1p 1276204 DIT1 852012 DIT1 Saccharomyces cerevisiae Dit1p NP_010691.1 1274594 D 4932 CDS NP_010692.1 6320612 852013 complement(1276646..1277161) 1 NC_001136.8 Rpb7p; RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p 1277161 RPB7 852013 RPB7 Saccharomyces cerevisiae RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p NP_010692.1 1276646 R 4932 CDS NP_010693.1 6320613 852014 1277638..1278429 1 NC_001136.8 Mrp20p; Mitochondrial ribosomal protein of the large subunit 1278429 MRP20 852014 MRP20 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit NP_010693.1 1277638 D 4932 CDS NP_010694.1 6320614 852015 1279202..1283791 1 NC_001136.8 Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element; Pdr15p 1283791 PDR15 852015 PDR15 Saccharomyces cerevisiae Pdr15p NP_010694.1 1279202 D 4932 CDS NP_010695.1 6320615 852016 complement(1284061..1287930) 1 NC_001136.8 Trs120p; One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic 1287930 TRS120 852016 TRS120 Saccharomyces cerevisiae One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic NP_010695.1 1284061 R 4932 CDS NP_010696.1 6320616 852017 complement(1288207..1288851) 1 NC_001136.8 Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; Ade8p 1288851 ADE8 852017 ADE8 Saccharomyces cerevisiae Ade8p NP_010696.1 1288207 R 4932 CDS NP_010697.1 6320617 852018 1289398..1292112 1 NC_001136.8 Siz1p; SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring 1292112 SIZ1 852018 SIZ1 Saccharomyces cerevisiae SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring NP_010697.1 1289398 D 4932 CDS NP_010698.1 6320618 852019 complement(1292364..1293083) 1 NC_001136.8 Ste14p; Farnesyl cysteine-carboxyl methyltransferase, mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS proteins in the endoplasmic reticulum, localizes to the ER membrane 1293083 STE14 852019 STE14 Saccharomyces cerevisiae Farnesyl cysteine-carboxyl methyltransferase, mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS proteins in the endoplasmic reticulum, localizes to the ER membrane NP_010698.1 1292364 R 4932 CDS NP_010699.1 6320619 852020 complement(1293361..1294386) 1 NC_001136.8 ER localized derlin-like family member involved in ER stress and homeostasis; not involved in ERAD or substrate retrotranslocation; interacts with CDC48; contains four transmembrane domains and two SHP boxes; Dfm1p 1294386 DFM1 852020 DFM1 Saccharomyces cerevisiae Dfm1p NP_010699.1 1293361 R 4932 CDS NP_010700.1 6320620 852021 1294685..1295392 1 NC_001136.8 Rrp17p; Protein required for cell viability 1295392 RRP17 852021 RRP17 Saccharomyces cerevisiae Protein required for cell viability NP_010700.1 1294685 D 4932 CDS NP_010702.1 6320622 852023 complement(1295590..1296678) 1 NC_001136.8 Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p); Erd1p 1296678 ERD1 852023 ERD1 Saccharomyces cerevisiae Erd1p NP_010702.1 1295590 R 4932 CDS NP_010703.1 6320623 852024 complement(1297029..1298153) 1 NC_001136.8 Ydr415cp; Putative protein of unknown function 1298153 852024 YDR415C Saccharomyces cerevisiae Putative protein of unknown function NP_010703.1 1297029 R 4932 CDS NP_010704.1 6320624 852025 1298424..1301003 1 NC_001136.8 Syf1p; Component of the spliceosome complex involved in pre-mRNA splicing; involved in regulation of cell cycle progression; similar to Drosophila crooked neck protein 1301003 SYF1 852025 SYF1 Saccharomyces cerevisiae Component of the spliceosome complex involved in pre-mRNA splicing; involved in regulation of cell cycle progression; similar to Drosophila crooked neck protein NP_010704.1 1298424 D 4932 CDS NP_010706.1 6320625 852026 1301608..1302105 1 NC_001136.8 Rpl12bp; Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Ap; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins 1302105 RPL12B 852026 RPL12B Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Ap; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins NP_010706.1 1301608 D 4932 CDS NP_010707.1 6320627 852028 1303166..1305064 1 NC_001136.8 Rad30p; DNA polymerase eta, involved in the predominantly error-free bypass replication of DNA lesions, catalyzes the efficient and accurate synthesis of DNA opposite cyclobutane pyrimidine dimers; homolog of human POLH and bacterial DinB proteins 1305064 RAD30 852028 RAD30 Saccharomyces cerevisiae DNA polymerase eta, involved in the predominantly error-free bypass replication of DNA lesions, catalyzes the efficient and accurate synthesis of DNA opposite cyclobutane pyrimidine dimers; homolog of human POLH and bacterial DinB proteins NP_010707.1 1303166 D 4932 CDS NP_010708.1 6320628 852030 1306259..1311667 1 NC_001136.8 Serine/threonine rich cell surface protein; osmosensor; involved in the regulation of cell wall beta-1,3 glucan synthesis, bud site selection and hyperosmotic response; overexpression confers resistance to Hansenula mrakii killer toxin HM-1; Hkr1p 1311667 HKR1 852030 HKR1 Saccharomyces cerevisiae Hkr1p NP_010708.1 1306259 D 4932 CDS NP_010709.1 6320629 852031 1312032..1314884 1 NC_001136.8 Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids; Aro80p 1314884 ARO80 852031 ARO80 Saccharomyces cerevisiae Aro80p NP_010709.1 1312032 D 4932 CDS NP_010710.2 93117373 852032 complement(1315318..1317765) 1 NC_001136.8 Sip1p; Alternate beta-subunit of the Snf1p kinase complex, may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions 1317765 SIP1 852032 SIP1 Saccharomyces cerevisiae Alternate beta-subunit of the Snf1p kinase complex, may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions NP_010710.2 1315318 R 4932 CDS NP_010711.1 6320631 852033 complement(1318038..1319267) 1 NC_001136.8 Cad1p; AP-1-like bZIP transcriptional activator involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; 5' UTR contains uORFs 1319267 CAD1 852033 CAD1 Saccharomyces cerevisiae AP-1-like bZIP transcriptional activator involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; 5' UTR contains uORFs NP_010711.1 1318038 R 4932 CDS NP_010712.1 6320632 852034 complement(join(1319379..1319609,1319690..1319712,1319809..1319833)) 1 NC_001136.8 Dyn2p; Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex 1319833 DYN2 852034 DYN2 Saccharomyces cerevisiae Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex NP_010712.1 1319379 R 4932 CDS NP_010713.1 6320633 852035 1320056..1321933 1 NC_001136.8 Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network; forms a complex with Snx4p and Atg20p; Snx41p 1321933 SNX41 852035 SNX41 Saccharomyces cerevisiae Snx41p NP_010713.1 1320056 D 4932 CDS NP_010715.1 6320635 852037 1322197..1323378 1 NC_001136.8 Rpn9p; Non-ATPase regulatory subunit of the 26S proteasome, has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects 1323378 RPN9 852037 RPN9 Saccharomyces cerevisiae Non-ATPase regulatory subunit of the 26S proteasome, has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects NP_010715.1 1322197 D 4932 CDS NP_010716.1 6320636 852038 complement(1323446..1324231) 1 NC_001136.8 Ydr428cp; Putative alpha/beta-serine hydrolase belonging to the subfamily of hormone-sensitive lipase-like hydrolases 1324231 852038 YDR428C Saccharomyces cerevisiae Putative alpha/beta-serine hydrolase belonging to the subfamily of hormone-sensitive lipase-like hydrolases NP_010716.1 1323446 R 4932 CDS NP_010717.1 6320637 852039 complement(1324469..1325293) 1 NC_001136.8 Tif35p; Subunit of the core complex of translation initiation factor 3(eIF3), which is essential for translation 1325293 TIF35 852039 TIF35 Saccharomyces cerevisiae Subunit of the core complex of translation initiation factor 3(eIF3), which is essential for translation NP_010717.1 1324469 R 4932 CDS NP_010718.1 6320639 852041 complement(1325493..1328462) 1 NC_001136.8 Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology; Cym1p 1328462 CYM1 852041 CYM1 Saccharomyces cerevisiae Cym1p NP_010718.1 1325493 R 4932 CDS NP_010720.1 6320640 852042 1328775..1330019 1 NC_001136.8 RNA-binding protein that carries poly(A)+ mRNA from the nucleus into the cytoplasm; dissociation from mRNAs is promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm; Npl3p 1330019 NPL3 852042 NPL3 Saccharomyces cerevisiae Npl3p NP_010720.1 1328775 D 4932 CDS NP_010722.1 6320642 852044 1331229..1332833 1 NC_001136.8 Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Sp homolog; Gpi17p 1332833 GPI17 852044 GPI17 Saccharomyces cerevisiae Gpi17p NP_010722.1 1331229 D 4932 CDS NP_010723.1 6320643 852045 complement(1332975..1333961) 1 NC_001136.8 Ppm1p; Carboxyl methyl transferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits 1333961 PPM1 852045 PPM1 Saccharomyces cerevisiae Carboxyl methyl transferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits NP_010723.1 1332975 R 4932 CDS NP_010724.1 6320644 852046 1334813..1336945 1 NC_001136.8 Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance; Ppz2p 1336945 PPZ2 852046 PPZ2 Saccharomyces cerevisiae Ppz2p NP_010724.1 1334813 D 4932 CDS NP_010725.1 6320645 852047 1337344..1337766 1 NC_001136.8 Subunit of GPI-GlcNAc transferase involved in synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), which is the first intermediate in glycosylphosphatidylinositol (GPI) anchor synthesis, shares similarity with mammalian PIG-P; Gpi19p 1337766 GPI19 852047 GPI19 Saccharomyces cerevisiae Gpi19p NP_010725.1 1337344 D 4932 CDS NP_010726.1 6320646 852048 1338266..1339378 1 NC_001136.8 Thi74p; Mitochondrial transporter repressible by thiamine 1339378 THI74 852048 THI74 Saccharomyces cerevisiae Mitochondrial transporter repressible by thiamine NP_010726.1 1338266 D 4932 CDS NP_010727.1 6320647 852049 1339668..1340711 1 NC_001136.8 Protein involved in rDNA silencing; positively charged coiled-coil protein with limited similarity to myosin; Lrs4p 1340711 LRS4 852049 LRS4 Saccharomyces cerevisiae Lrs4p NP_010727.1 1339668 D 4932 CDS NP_010728.1 6320648 852050 1342485..1344233 1 NC_001136.8 Nucleosomal histone H3-Lys79 methylase, associates with transcriptionally active genes, functions in gene silencing at telomeres, most likely by directly modulating chromatin structure and Sir protein localization; Dot1p 1344233 DOT1 852050 DOT1 Saccharomyces cerevisiae Dot1p NP_010728.1 1342485 D 4932 CDS NP_010729.1 6320649 852051 complement(1344509..1345054) 1 NC_001136.8 Apt2p; Apparent pseudogene, not transcribed or translated under normal conditions; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity 1345054 APT2 852051 APT2 Saccharomyces cerevisiae Apparent pseudogene, not transcribed or translated under normal conditions; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity NP_010729.1 1344509 R 4932 CDS NP_010731.1 6320651 852053 complement(1345668..1349930) 1 NC_001136.8 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation; Ssn2p 1349930 SSN2 852053 SSN2 Saccharomyces cerevisiae Ssn2p NP_010731.1 1345668 R 4932 CDS NP_010732.1 6320652 852054 1350282..1352345 1 NC_001136.8 Ydr444wp; Putative protein of unknown function 1352345 852054 YDR444W Saccharomyces cerevisiae Putative protein of unknown function NP_010732.1 1350282 D 4932 CDS NP_010734.1 6320654 852057 1353717..1354625 1 NC_001136.8 Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure; Ecm11p 1354625 ECM11 852057 ECM11 Saccharomyces cerevisiae Ecm11p NP_010734.1 1353717 D 4932 CDS NP_010735.1 6320655 852058 complement(join(1354821..1355228,1355543..1355545)) 1 NC_001136.8 Rps17bp; Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Ap and has similarity to rat S17 ribosomal protein 1355545 RPS17B 852058 RPS17B Saccharomyces cerevisiae Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Ap and has similarity to rat S17 ribosomal protein NP_010735.1 1354821 R 4932 CDS NP_010736.1 6320656 852059 1356057..1357361 1 NC_001136.8 Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes; Ada2p 1357361 ADA2 852059 ADA2 Saccharomyces cerevisiae Ada2p NP_010736.1 1356057 D 4932 CDS NP_010737.1 6320657 852060 complement(1357572..1358894) 1 NC_001136.8 Utp6p; Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA 1358894 UTP6 852060 UTP6 Saccharomyces cerevisiae Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA NP_010737.1 1357572 R 4932 CDS NP_010738.1 6320658 852061 join(1359915..1359961,1360397..1360790) 1 NC_001136.8 Rps18ap; Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Bp and has similarity to E. coli S13 and rat S18 ribosomal proteins 1360790 RPS18A 852061 RPS18A Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Bp and has similarity to E. coli S13 and rat S18 ribosomal proteins NP_010738.1 1359915 D 4932 CDS NP_010739.1 6320659 852062 complement(1361112..1362173) 1 NC_001136.8 Yhp1p; One of two homeobox transcriptional repressors (see also Yox1p), that bind to Mcm1p and to early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval 1362173 YHP1 852062 YHP1 Saccharomyces cerevisiae One of two homeobox transcriptional repressors (see also Yox1p), that bind to Mcm1p and to early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval NP_010739.1 1361112 R 4932 CDS NP_010740.1 6320660 852063 1362870..1364894 1 NC_001136.8 Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; Ppn1p 1364894 PPN1 852063 PPN1 Saccharomyces cerevisiae Ppn1p NP_010740.1 1362870 D 4932 CDS NP_010741.1 6320661 852064 complement(1365064..1365654) 1 NC_001136.8 Tsa2p; Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants 1365654 TSA2 852064 TSA2 Saccharomyces cerevisiae Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants NP_010741.1 1365064 R 4932 CDS NP_010742.1 6320662 852065 complement(1366256..1366819) 1 NC_001136.8 Guk1p; Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins 1366819 GUK1 852065 GUK1 Saccharomyces cerevisiae Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins NP_010742.1 1366256 R 4932 CDS NP_010744.1 6320663 852066 1367477..1369378 1 NC_001136.8 Nhx1p; Endosomal Na+/H+ exchanger, required for intracellular sequestration of Na+; required for osmotolerance to acute hypertonic shock 1369378 NHX1 852066 NHX1 Saccharomyces cerevisiae Endosomal Na+/H+ exchanger, required for intracellular sequestration of Na+; required for osmotolerance to acute hypertonic shock NP_010744.1 1367477 D 4932 CDS NP_010745.1 6320665 852068 1369782..1379588 1 NC_001136.8 Tom1p; E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators 1379588 TOM1 852068 TOM1 Saccharomyces cerevisiae E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators NP_010745.1 1369782 D 4932 CDS NP_010746.1 6320666 852069 complement(1380047..1382038) 1 NC_001136.8 Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle; Heh2p 1382038 HEH2 852069 HEH2 Saccharomyces cerevisiae Heh2p NP_010746.1 1380047 R 4932 CDS NP_010747.1 6320667 852070 complement(1382311..1383435) 1 NC_001136.8 Pfa5p; Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain 1383435 PFA5 852070 PFA5 Saccharomyces cerevisiae Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain NP_010747.1 1382311 R 4932 CDS NP_010748.1 6320668 852071 1383803..1384768 1 NC_001136.8 Tfb3p; Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit 1384768 TFB3 852071 TFB3 Saccharomyces cerevisiae Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit NP_010748.1 1383803 D 4932 CDS NP_010749.1 6320669 852072 1385168..1385278 1 NC_001136.8 Mfa1p; Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA2 1385278 MFA1 852072 MFA1 Saccharomyces cerevisiae Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA2 NP_010749.1 1385168 D 4932 CDS NP_001032577.1 82795248 3799972 complement(1385516..1385758) 1 NC_001136.8 Ydr461c-ap; Putative protein of unknown function 1385758 3799972 YDR461C-A Saccharomyces cerevisiae Putative protein of unknown function NP_001032577.1 1385516 R 4932 CDS NP_010750.1 6320670 852073 1386065..1386508 1 NC_001136.8 Mrpl28p; Mitochondrial ribosomal protein of the large subunit 1386508 MRPL28 852073 MRPL28 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit NP_010750.1 1386065 D 4932 CDS NP_010751.2 37362636 852074 1386808..1388367 1 NC_001136.8 Transcription factor, activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing; Stp1p 1388367 STP1 852074 STP1 Saccharomyces cerevisiae Stp1p NP_010751.2 1386808 D 4932 CDS NP_010752.1 6320672 852075 1388864..1393171 1 NC_001136.8 Spp41p; Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3 1393171 SPP41 852075 SPP41 Saccharomyces cerevisiae Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3 NP_010752.1 1388864 D 4932 CDS NP_010753.1 6320673 852076 complement(1393328..1394566) 1 NC_001136.8 Rmt2p; Arginine methyltransferase; ribosomal protein L12 is a substrate 1394566 RMT2 852076 RMT2 Saccharomyces cerevisiae Arginine methyltransferase; ribosomal protein L12 is a substrate NP_010753.1 1393328 R 4932 CDS NP_010754.1 6320674 852077 1395113..1397809 1 NC_001136.8 Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant; Pkh3p 1397809 PKH3 852077 PKH3 Saccharomyces cerevisiae Pkh3p NP_010754.1 1395113 D 4932 CDS NP_010756.1 6320676 852079 complement(1398018..1398692) 1 NC_001136.8 Tlg1p; Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p 1398692 TLG1 852079 TLG1 Saccharomyces cerevisiae Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p NP_010756.1 1398018 R 4932 CDS NP_010757.1 6320677 852080 1399007..1399534 1 NC_001136.8 Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; has similarity to C. elegans Dpy-30; Sdc1p 1399534 SDC1 852080 SDC1 Saccharomyces cerevisiae Sdc1p NP_010757.1 1399007 D 4932 CDS NP_010758.2 7839165 852081 complement(1399698..1401206) 1 NC_001136.8 Ugo1p; Protein of unknown function; outer membrane component of the mitochondrial fusion machinery; Ugo1p bind directly to Fzo1p and Mgm1p and thereby link these two GTPases during mitochondrial fusion 1401206 UGO1 852081 UGO1 Saccharomyces cerevisiae Protein of unknown function; outer membrane component of the mitochondrial fusion machinery; Ugo1p bind directly to Fzo1p and Mgm1p and thereby link these two GTPases during mitochondrial fusion NP_010758.2 1399698 R 4932 CDS NP_010759.1 6320679 852082 join(1401762..1401792,1402177..1402556) 1 NC_001136.8 Rpl27bp; Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Ap and has similarity to rat L27 ribosomal protein 1402556 RPL27B 852082 RPL27B Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Ap and has similarity to rat L27 ribosomal protein NP_010759.1 1401762 D 4932 CDS NP_010760.1 6320680 852083 1403314..1404165 1 NC_001136.8 Trs31p; One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic 1404165 TRS31 852083 TRS31 Saccharomyces cerevisiae One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic NP_010760.1 1403314 D 4932 CDS NP_010761.1 6320681 852084 complement(1404437..1405846) 1 NC_001136.8 Splicing factor, component of the U4/U6-U5 snRNP complex; Prp3p 1405846 PRP3 852084 PRP3 Saccharomyces cerevisiae Prp3p NP_010761.1 1404437 R 4932 CDS NP_010763.2 37362637 852086 complement(1407456..1410086) 1 NC_001136.8 Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence; Jip4p 1410086 JIP4 852086 JIP4 Saccharomyces cerevisiae Jip4p NP_010763.2 1407456 R 4932 CDS NP_010764.1 6320684 852087 complement(1410445..1411119) 1 NC_001136.8 Ydr476cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene 1411119 852087 YDR476C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene NP_010764.1 1410445 R 4932 CDS NP_010765.1 6320685 852088 1412365..1414266 1 NC_001136.8 Snf1p; AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis 1414266 SNF1 852088 SNF1 Saccharomyces cerevisiae AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis NP_010765.1 1412365 D 4932 CDS NP_010766.1 6320686 852089 1414567..1415163 1 NC_001136.8 Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP; Snm1p 1415163 SNM1 852089 SNM1 Saccharomyces cerevisiae Snm1p NP_010766.1 1414567 D 4932 CDS NP_010767.1 6320687 852090 complement(1415202..1416866) 1 NC_001136.8 Pex29p; Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p 1416866 PEX29 852090 PEX29 Saccharomyces cerevisiae Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p NP_010767.1 1415202 R 4932 CDS NP_010768.1 6320688 852091 1417391..1418362 1 NC_001136.8 Regulatory protein of unknown function, pheromone-inducible, involved in the regulation of mating-specific genes and the invasive growth pathway, required for MAP-kinase imposed repression, inhibits pheromone-responsive transcription; Dig2p 1418362 DIG2 852091 DIG2 Saccharomyces cerevisiae Dig2p NP_010768.1 1417391 D 4932 CDS NP_010769.1 6320689 852092 complement(1418542..1420242) 1 NC_001136.8 Repressible alkaline phosphatase, a glycoprotein localized to the vacuole; regulated by levels of inorganic phosphate and by a system consisting of Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; Pho8p 1420242 PHO8 852092 PHO8 Saccharomyces cerevisiae Pho8p NP_010769.1 1418542 R 4932 CDS NP_010770.1 6320690 852093 complement(1420423..1420830) 1 NC_001136.8 Cwc21p; Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; may bind RNA; has similarity to S. pombe Cwf21p 1420830 CWC21 852093 CWC21 Saccharomyces cerevisiae Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; may bind RNA; has similarity to S. pombe Cwf21p NP_010770.1 1420423 R 4932 CDS NP_010771.1 6320691 852094 1421149..1422477 1 NC_001136.8 Kre2p; Alpha1,2-mannosyltransferase of the Golgi involved in protein mannosylation 1422477 KRE2 852094 KRE2 Saccharomyces cerevisiae Alpha1,2-mannosyltransferase of the Golgi involved in protein mannosylation NP_010771.1 1421149 D 4932 CDS NP_010772.1 6320692 852095 1422755..1424680 1 NC_001136.8 Vps52p; Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin 1424680 VPS52 852095 VPS52 Saccharomyces cerevisiae Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin NP_010772.1 1422755 D 4932 CDS NP_010773.2 37362638 852096 complement(1424812..1427199) 1 NC_001136.8 Vps72p; Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting 1427199 VPS72 852096 VPS72 Saccharomyces cerevisiae Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting NP_010773.2 1424812 R 4932 CDS NP_010774.2 37362639 852097 complement(1427423..1428112) 1 NC_001136.8 Vps60p; Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport; required for normal filament maturation during pseudohyphal growth; may function in targeting specific cargo proteins for degradation 1428112 VPS60 852097 VPS60 Saccharomyces cerevisiae Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport; required for normal filament maturation during pseudohyphal growth; may function in targeting specific cargo proteins for degradation NP_010774.2 1427423 R 4932 CDS NP_010775.1 6320695 852098 complement(1428346..1428972) 1 NC_001136.8 Rib3p; 3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration 1428972 RIB3 852098 RIB3 Saccharomyces cerevisiae 3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration NP_010775.1 1428346 R 4932 CDS NP_010776.1 6320696 852099 complement(1429180..1430781) 1 NC_001136.8 Pac11p; Dynein intermediate chain, acts in the cytoplasmic dynein pathway, forms cortical cytoplasmic microtubule capture site with Num1p; null mutant is defective in nuclear migration, essential in the absence of CIN8 1430781 PAC11 852099 PAC11 Saccharomyces cerevisiae Dynein intermediate chain, acts in the cytoplasmic dynein pathway, forms cortical cytoplasmic microtubule capture site with Num1p; null mutant is defective in nuclear migration, essential in the absence of CIN8 NP_010776.1 1429180 R 4932 CDS NP_010777.1 6320697 852100 1431004..1431888 1 NC_001136.8 Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery; Sld5p 1431888 SLD5 852100 SLD5 Saccharomyces cerevisiae Sld5p NP_010777.1 1431004 D 4932 CDS NP_010778.1 6320698 852101 complement(1431960..1434260) 1 NC_001136.8 Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p; Pkh1p 1434260 PKH1 852101 PKH1 Saccharomyces cerevisiae Pkh1p NP_010778.1 1431960 R 4932 CDS NP_010780.1 6320699 852102 1434916..1435866 1 NC_001136.8 Membrane protein involved in zinc metabolism, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc; Izh1p 1435866 IZH1 852102 IZH1 Saccharomyces cerevisiae Izh1p NP_010780.1 1434916 D 4932 CDS NP_010781.1 6320701 852104 1436209..1436580 1 NC_001136.8 Protein of unknown function; non-tagged protein detected in purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss and severe growth defect in minimal glycerol media; Aim8p 1436580 AIM8 852104 AIM8 Saccharomyces cerevisiae Aim8p NP_010781.1 1436209 D 4932 CDS NP_010782.2 27469362 852105 1436922..1438007 1 NC_001136.8 Rsm28p; Mitochondrial ribosomal protein of the small subunit; genetic interactions suggest a possible role in promoting translation initiation 1438007 RSM28 852105 RSM28 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the small subunit; genetic interactions suggest a possible role in promoting translation initiation NP_010782.2 1436922 D 4932 CDS NP_010783.1 6320703 852106 complement(1438107..1441142) 1 NC_001136.8 Vps3p; Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase 1441142 VPS3 852106 VPS3 Saccharomyces cerevisiae Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase NP_010783.1 1438107 R 4932 CDS NP_010784.1 6320704 852107 complement(1441425..1443395) 1 NC_001136.8 Pumilio-homology domain protein that binds ASH1 mRNA at PUF consensus sequences in the 3' UTR and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA; Puf6p 1443395 PUF6 852107 PUF6 Saccharomyces cerevisiae Puf6p NP_010784.1 1441425 R 4932 CDS NP_010785.1 6320705 852108 complement(1443705..1445459) 1 NC_001136.8 Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; Itr1p 1445459 ITR1 852108 ITR1 Saccharomyces cerevisiae Itr1p NP_010785.1 1443705 R 4932 CDS NP_010786.1 6320706 852109 complement(1445835..1446986) 1 NC_001136.8 Sec20p; Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER; forms a complex with the cytosolic Tip20p 1446986 SEC20 852109 SEC20 Saccharomyces cerevisiae Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER; forms a complex with the cytosolic Tip20p NP_010786.1 1445835 R 4932 CDS NP_010787.1 6320707 852110 1447822..1450065 1 NC_001136.8 Lcd1p; Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP 1450065 LCD1 852110 LCD1 Saccharomyces cerevisiae Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP NP_010787.1 1447822 D 4932 CDS NP_010788.1 6320708 852111 complement(join(1450190..1450449,1450839..1450845)) 1 NC_001136.8 Rpl37bp; Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Ap and to rat L37 ribosomal protein 1450845 RPL37B 852111 RPL37B Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Ap and to rat L37 ribosomal protein NP_010788.1 1450190 R 4932 CDS NP_010789.1 6320709 852112 1451345..1452910 1 NC_001136.8 Protein required for partitioning of the 2-micron plasmid; Plm2p 1452910 PLM2 852112 PLM2 Saccharomyces cerevisiae Plm2p NP_010789.1 1451345 D 4932 CDS NP_010790.1 6320710 852113 complement(1453302..1454456) 1 NC_001136.8 Sam2p; S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p) 1454456 SAM2 852113 SAM2 Saccharomyces cerevisiae S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p) NP_010790.1 1453302 R 4932 CDS NP_010791.1 6320711 852114 complement(1455034..1455858) 1 NC_001136.8 Lpp1p; Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA 1455858 LPP1 852114 LPP1 Saccharomyces cerevisiae Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA NP_010791.1 1455034 R 4932 CDS NP_010792.1 6320712 852115 complement(1456303..1456686) 1 NC_001136.8 Spg3p; Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources 1456686 SPG3 852115 SPG3 Saccharomyces cerevisiae Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources NP_010792.1 1456303 R 4932 CDS NP_010793.1 6320713 852116 complement(1456687..1459212) 1 NC_001136.8 Psp1p; Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition 1459212 PSP1 852116 PSP1 Saccharomyces cerevisiae Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition NP_010793.1 1456687 R 4932 CDS NP_010794.1 6320714 852117 complement(1459720..1461546) 1 NC_001136.8 Ydr506cp; Possible membrane-localized protein 1461546 852117 YDR506C Saccharomyces cerevisiae Possible membrane-localized protein NP_010794.1 1459720 R 4932 CDS NP_010795.1 6320715 852119 complement(1462350..1465778) 1 NC_001136.8 Protein kinase involved in bud growth and assembly of the septin ring, proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Kcc4p and Hsl1p; Gin4p 1465778 GIN4 852119 GIN4 Saccharomyces cerevisiae Gin4p NP_010795.1 1462350 R 4932 CDS NP_010796.1 6320717 852121 complement(1466445..1468436) 1 NC_001136.8 High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; Gnp1p 1468436 GNP1 852121 GNP1 Saccharomyces cerevisiae Gnp1p NP_010796.1 1466445 R 4932 CDS NP_010798.1 6320718 852122 1469392..1469697 1 NC_001136.8 Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; Smt3p 1469697 SMT3 852122 SMT3 Saccharomyces cerevisiae Smt3p NP_010798.1 1469392 D 4932 CDS NP_010799.1 6320719 852123 1470009..1470410 1 NC_001136.8 Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes; Acn9p 1470410 ACN9 852123 ACN9 Saccharomyces cerevisiae Acn9p NP_010799.1 1470009 D 4932 CDS NP_010800.1 6320721 852125 complement(1470492..1471055) 1 NC_001136.8 Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; Emi1p 1471055 EMI1 852125 EMI1 Saccharomyces cerevisiae Emi1p NP_010800.1 1470492 R 4932 CDS NP_010801.1 6320720 852124 1471009..1471440 1 NC_001136.8 Grx2p; Cytoplasmic glutaredoxin, thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress 1471440 GRX2 852124 GRX2 Saccharomyces cerevisiae Cytoplasmic glutaredoxin, thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress NP_010801.1 1471009 D 4932 CDS NP_010802.1 6320722 852126 complement(1471540..1472991) 1 NC_001136.8 Ydr514cp; Putative protein of unknown function 1472991 852126 YDR514C Saccharomyces cerevisiae Putative protein of unknown function NP_010802.1 1471540 R 4932 CDS NP_010803.1 6320723 852127 1473421..1474764 1 NC_001136.8 Slf1p; RNA binding protein that associates with polysomes; proposed to be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts 1474764 SLF1 852127 SLF1 Saccharomyces cerevisiae RNA binding protein that associates with polysomes; proposed to be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts NP_010803.1 1473421 D 4932 CDS NP_010804.1 6320724 852128 complement(1474966..1476468) 1 NC_001136.8 Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression is regulated by glucose-repression transcription factors Mig1/2p; Emi2p 1476468 EMI2 852128 EMI2 Saccharomyces cerevisiae Emi2p NP_010804.1 1474966 R 4932 CDS NP_010805.1 6320725 852129 1477231..1478349 1 NC_001136.8 Grh1p; Acetylated, cis-golgi localized protein involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes 1478349 GRH1 852129 GRH1 Saccharomyces cerevisiae Acetylated, cis-golgi localized protein involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes NP_010805.1 1477231 D 4932 CDS NP_010806.1 6320726 852130 1478600..1480153 1 NC_001136.8 Protein disulfide isomerase of the endoplasmic reticulum lumen, function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER; Eug1p 1480153 EUG1 852130 EUG1 Saccharomyces cerevisiae Eug1p NP_010806.1 1478600 D 4932 CDS NP_010807.1 6320727 852131 1480417..1480824 1 NC_001136.8 Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; Fpr2p 1480824 FPR2 852131 FPR2 Saccharomyces cerevisiae Fpr2p NP_010807.1 1480417 D 4932 CDS NP_010808.1 6320729 852133 complement(1481077..1483395) 1 NC_001136.8 Ydr520cp; Putative transcription factor; contains the (Zn(II)2Cys6 motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is viable and sensitive to caffeine 1483395 852133 YDR520C Saccharomyces cerevisiae Putative transcription factor; contains the (Zn(II)2Cys6 motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is viable and sensitive to caffeine NP_010808.1 1481077 R 4932 CDS NP_010810.1 6320730 852134 complement(1483787..1485295) 1 NC_001136.8 Sps2p; Protein expressed during sporulation, redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component 1485295 SPS2 852134 SPS2 Saccharomyces cerevisiae Protein expressed during sporulation, redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component NP_010810.1 1483787 R 4932 CDS NP_010811.1 6320731 852135 complement(1485558..1487030) 1 NC_001136.8 Sps1p; Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis 1487030 SPS1 852135 SPS1 Saccharomyces cerevisiae Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis NP_010811.1 1485558 R 4932 CDS NP_010812.1 6320732 852136 complement(1487534..1488982) 1 NC_001136.8 Age1p; ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif 1488982 AGE1 852136 AGE1 Saccharomyces cerevisiae ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif NP_010812.1 1487534 R 4932 CDS NP_878066.1 33438784 1466437 1489395..1489484 1 NC_001136.8 Ydr524w-cp; Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin 1489484 1466437 YDR524W-C Saccharomyces cerevisiae Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin NP_878066.1 1489395 D 4932 CDS NP_878067.1 33438785 1466438 complement(1489590..1489790) 1 NC_001136.8 Ydr524c-bp; Putative protein of unknown function 1489790 1466438 YDR524C-B Saccharomyces cerevisiae Putative protein of unknown function NP_878067.1 1489590 R 4932 CDS NP_010814.1 6320734 852138 1490588..1490827 1 NC_001136.8 Sna2p; Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 1490827 SNA2 852138 SNA2 Saccharomyces cerevisiae Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern NP_010814.1 1490588 D 4932 CDS NP_010816.1 6320735 852139 1491086..1492405 1 NC_001136.8 Rba50p; Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1 1492405 RBA50 852139 RBA50 Saccharomyces cerevisiae Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1 NP_010816.1 1491086 D 4932 CDS NP_010817.1 6320737 852141 1494578..1495849 1 NC_001136.8 Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A; Hlr1p 1495849 HLR1 852141 HLR1 Saccharomyces cerevisiae Hlr1p NP_010817.1 1494578 D 4932 CDS NP_010818.1 6320738 852142 complement(1496157..1496540) 1 NC_001136.8 Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly; Qcr7p 1496540 QCR7 852142 QCR7 Saccharomyces cerevisiae Qcr7p NP_010818.1 1496157 R 4932 CDS NP_010819.1 6320739 852143 complement(1496783..1497760) 1 NC_001136.8 Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase II (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa1p; Apa2p 1497760 APA2 852143 APA2 Saccharomyces cerevisiae Apa2p NP_010819.1 1496783 R 4932 CDS NP_010820.1 6320740 852144 1498224..1499327 1 NC_001136.8 Ydr531wp; Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway leading to coenzyme A1 1499327 852144 YDR531W Saccharomyces cerevisiae Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway leading to coenzyme A1 NP_010820.1 1498224 D 4932 CDS NP_010821.1 6320741 852145 complement(1499388..1500545) 1 NC_001136.8 Ydr532cp; Protein of unknown function that localizes to the nuclear side of the spindle pole body and along short spindles; deletion mutants have short telomeres; forms a complex with Spc105p 1500545 852145 YDR532C Saccharomyces cerevisiae Protein of unknown function that localizes to the nuclear side of the spindle pole body and along short spindles; deletion mutants have short telomeres; forms a complex with Spc105p NP_010821.1 1499388 R 4932 CDS NP_010822.1 6320742 852146 complement(1501439..1502152) 1 NC_001136.8 Possible chaperone and cysteine protease with similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; Hsp31p 1502152 HSP31 852146 HSP31 Saccharomyces cerevisiae Hsp31p NP_010822.1 1501439 R 4932 CDS NP_010823.1 6320743 852147 complement(1503305..1504891) 1 NC_001136.8 Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall; Fit1p 1504891 FIT1 852147 FIT1 Saccharomyces cerevisiae Fit1p NP_010823.1 1503305 R 4932 CDS NP_010825.1 6320745 852149 1507996..1509705 1 NC_001136.8 Stl1p; Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock 1509705 STL1 852149 STL1 Saccharomyces cerevisiae Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock NP_010825.1 1507996 D 4932 CDS NP_010827.1 6320746 852150 1510892..1511620 1 NC_001136.8 Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; homolog of E. coli UbiX; Pad1p 1511620 PAD1 852150 PAD1 Saccharomyces cerevisiae Pad1p NP_010827.1 1510892 D 4932 CDS NP_010828.1 6320748 852152 1512084..1513595 1 NC_001136.8 Ydr539wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR539W is not an essential gene; homolog of E. coli UbiD 1513595 852152 YDR539W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR539W is not an essential gene; homolog of E. coli UbiD NP_010828.1 1512084 D 4932 CDS NP_010829.1 6320749 852153 complement(1517120..1517659) 1 NC_001136.8 hypothetical protein; null mutant displays increased levels of spontaneous Rad52 foci; Irc4p 1517659 IRC4 852153 IRC4 Saccharomyces cerevisiae Irc4p NP_010829.1 1517120 R 4932 CDS NP_010830.1 6320750 852154 complement(1519648..1520682) 1 NC_001136.8 Ydr541cp; Putative dihydrokaempferol 4-reductase 1520682 852154 YDR541C Saccharomyces cerevisiae Putative dihydrokaempferol 4-reductase NP_010830.1 1519648 R 4932 CDS NP_010831.1 6320751 852155 1523234..1523596 1 NC_001136.8 Pau10p 1523596 PAU10 852155 PAU10 Saccharomyces cerevisiae Pau10p NP_010831.1 1523234 D 4932 CDS NP_010834.1 6320754 852158 1526306..1531696 1 NC_001136.8 Yrf1-1p; Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p 1531696 YRF1-1 852158 YRF1-1 Saccharomyces cerevisiae Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p NP_010834.1 1526306 D 4932 CDS NP_012092.1 6322017 854630 complement(join(483..4598,4987..6147)) 1 NC_001141.1 Yil177cp; Putative protein of unknown function; similarity to DNA helicases that are encoded within subtelomeric Y' elements and induced in telomerase deficient survivors 6147 854630 YIL177C Saccharomyces cerevisiae Putative protein of unknown function; similarity to DNA helicases that are encoded within subtelomeric Y' elements and induced in telomerase deficient survivors NP_012092.1 483 R 4932 CDS NP_012093.1 6322018 854631 complement(8793..9155) 1 NC_001141.1 Pau14p 9155 PAU14 854631 PAU14 Saccharomyces cerevisiae Pau14p NP_012093.1 8793 R 4932 CDS NP_012095.1 6322020 854634 11492..16141 1 NC_001141.1 Vth1p; Putative membrane glycoprotein with strong similarity to Vth2p and Pep1p/Vps10p, may be involved in vacuolar protein sorting 16141 VTH1 854634 VTH1 Saccharomyces cerevisiae Putative membrane glycoprotein with strong similarity to Vth2p and Pep1p/Vps10p, may be involved in vacuolar protein sorting NP_012095.1 11492 D 4932 CDS NP_012096.1 6322021 854635 complement(16784..18553) 1 NC_001141.1 Yil172cp; Putative protein of unknown function with similarity to glucosidases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 18553 854635 YIL172C Saccharomyces cerevisiae Putative protein of unknown function with similarity to glucosidases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm NP_012096.1 16784 R 4932 CDS NP_012097.1 6322022 854637 complement(23119..26106) 1 NC_001141.1 Yil169cp; Putative protein of unknown function; serine/threonine rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; YIL169C is a non-essential gene 26106 854637 YIL169C Saccharomyces cerevisiae Putative protein of unknown function; serine/threonine rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; YIL169C is a non-essential gene NP_012097.1 23119 R 4932 CDS NP_012100.1 6322025 854640 complement(30938..32566) 1 NC_001141.1 Yil166cp; Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene 32566 854640 YIL166C Saccharomyces cerevisiae Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene NP_012100.1 30938 R 4932 CDS NP_012101.1 6322026 854641 complement(33718..34077) 1 NC_001141.1 Yil165cp; Putative protein of unknown function; in closely related species and other S. cerevisiae strain backgrounds YIL165C and adjacent ORF, YIL164C, likely constitute a single ORF encoding a nitrilase gene 34077 854641 YIL165C Saccharomyces cerevisiae Putative protein of unknown function; in closely related species and other S. cerevisiae strain backgrounds YIL165C and adjacent ORF, YIL164C, likely constitute a single ORF encoding a nitrilase gene NP_012101.1 33718 R 4932 CDS NP_012102.1 6322027 854642 complement(34087..34686) 1 NC_001141.1 Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene; Nit1p 34686 NIT1 854642 NIT1 Saccharomyces cerevisiae Nit1p NP_012102.1 34087 R 4932 CDS NP_012104.1 6322029 854644 37385..38983 1 NC_001141.1 Suc2p; Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively 38983 SUC2 854644 SUC2 Saccharomyces cerevisiae Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively NP_012104.1 37385 D 4932 CDS NP_012105.1 6322030 854645 39433..40140 1 NC_001141.1 Yil161wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene 40140 854645 YIL161W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene NP_012105.1 39433 D 4932 CDS NP_012106.1 6322031 854646 complement(40191..41444) 1 NC_001141.1 Pot1p; 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids 41444 POT1 854646 POT1 Saccharomyces cerevisiae 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids NP_012106.1 40191 R 4932 CDS NP_012107.1 6322032 854647 41825..45952 1 NC_001141.1 Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1; Bnr1p 45952 BNR1 854647 BNR1 Saccharomyces cerevisiae Bnr1p NP_012107.1 41825 D 4932 CDS NP_012108.1 6322033 854648 46201..46815 1 NC_001141.1 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; null mutant displays increased frequency of mitochondrial genome loss (petite formation); Aim20p 46815 AIM20 854648 AIM20 Saccharomyces cerevisiae Aim20p NP_012108.1 46201 D 4932 CDS NP_012109.1 6322034 854649 complement(46949..47542) 1 NC_001141.1 Mitochondrial inner membrane protein required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assembly; Coa1p 47542 COA1 854649 COA1 Saccharomyces cerevisiae Coa1p NP_012109.1 46949 R 4932 CDS NP_001027534.1 73858744 3628034 join(47690..47698,47761..47973) 1 NC_001141.1 Yil156w-bp; Putative protein of unknown function, originally identified based on homology to Ashbya gossypii and other related yeasts 47973 3628034 YIL156W-B Saccharomyces cerevisiae Putative protein of unknown function, originally identified based on homology to Ashbya gossypii and other related yeasts NP_001027534.1 47690 D 4932 CDS NP_012110.1 6322035 854650 48091..51306 1 NC_001141.1 Ubp7p; Ubiquitin-specific protease that cleaves ubiquitin-protein fusions 51306 UBP7 854650 UBP7 Saccharomyces cerevisiae Ubiquitin-specific protease that cleaves ubiquitin-protein fusions NP_012110.1 48091 D 4932 CDS NP_012111.1 6322036 854651 complement(51759..53708) 1 NC_001141.1 Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner; Gut2p 53708 GUT2 854651 GUT2 Saccharomyces cerevisiae Gut2p NP_012111.1 51759 R 4932 CDS NP_012112.1 6322037 854652 complement(53981..55021) 1 NC_001141.1 Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat; Imp2'p 55021 IMP2' 854652 IMP2' Saccharomyces cerevisiae Imp2'p NP_012112.1 53981 R 4932 CDS NP_012113.1 6322038 854653 55198..56379 1 NC_001141.1 Rrd1p; Activator of the phosphotyrosyl phosphatase activity of PP2A, peptidyl-prolyl cis/trans-isomerase; regulates G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; subunit of the Tap42p-Sit4p-Rrd1p complex 56379 RRD1 854653 RRD1 Saccharomyces cerevisiae Activator of the phosphotyrosyl phosphatase activity of PP2A, peptidyl-prolyl cis/trans-isomerase; regulates G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; subunit of the Tap42p-Sit4p-Rrd1p complex NP_012113.1 55198 D 4932 CDS NP_012114.1 6322039 854654 56545..57252 1 NC_001141.1 Yil152wp; Putative protein of unknown function 57252 854654 YIL152W Saccharomyces cerevisiae Putative protein of unknown function NP_012114.1 56545 D 4932 CDS NP_012115.1 6322040 854655 complement(57338..60694) 1 NC_001141.1 Yil151cp; Putative protein of unknown function, predicted to contain a PINc (PilT N terminus) domain 60694 854655 YIL151C Saccharomyces cerevisiae Putative protein of unknown function, predicted to contain a PINc (PilT N terminus) domain NP_012115.1 57338 R 4932 CDS NP_012116.1 6322041 854656 complement(61013..62728) 1 NC_001141.1 Mcm10p; Essential chromatin-associated protein involved in the initiation of DNA replication; required for the association of the MCM2-7 complex with replication origins 62728 MCM10 854656 MCM10 Saccharomyces cerevisiae Essential chromatin-associated protein involved in the initiation of DNA replication; required for the association of the MCM2-7 complex with replication origins NP_012116.1 61013 R 4932 CDS NP_012117.1 6322042 854657 complement(63028..68067) 1 NC_001141.1 Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length; Mlp2p 68067 MLP2 854657 MLP2 Saccharomyces cerevisiae Mlp2p NP_012117.1 63028 R 4932 CDS NP_012118.1 6322043 854658 join(68708..68715,69150..69528) 1 NC_001141.1 Rpl40ap; Fusion protein, identical to Rpl40Bp, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes 69528 RPL40A 854658 RPL40A Saccharomyces cerevisiae Fusion protein, identical to Rpl40Bp, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes NP_012118.1 68708 D 4932 CDS NP_012119.1 6322044 854659 complement(69791..73453) 1 NC_001141.1 Sln1p; Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators 73453 SLN1 854659 SLN1 Saccharomyces cerevisiae Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators NP_012119.1 69791 R 4932 CDS NP_012120.1 6322045 854660 complement(74184..75773) 1 NC_001141.1 Non-essential protein of unknown function; Ecm37p 75773 ECM37 854660 ECM37 Saccharomyces cerevisiae Ecm37p NP_012120.1 74184 R 4932 CDS NP_012121.2 37362661 854661 complement(76354..77283) 1 NC_001141.1 Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC; Pan6p 77283 PAN6 854661 PAN6 Saccharomyces cerevisiae Pan6p NP_012121.2 76354 R 4932 CDS NP_012122.1 6322047 854662 78074..80149 1 NC_001141.1 Tid3p; Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering 80149 TID3 854662 TID3 Saccharomyces cerevisiae Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering NP_012122.1 78074 D 4932 CDS NP_012123.1 6322048 854663 complement(80510..83041) 1 NC_001141.1 Ssl2p; Component of the holoenzyme form of RNA polymerase transcription factor TFIIH, has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; involved in DNA repair; homolog of human ERCC3 83041 SSL2 854663 SSL2 Saccharomyces cerevisiae Component of the holoenzyme form of RNA polymerase transcription factor TFIIH, has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; involved in DNA repair; homolog of human ERCC3 NP_012123.1 80510 R 4932 CDS NP_012124.1 6322049 854664 83302..84885 1 NC_001141.1 Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; Cct2p 84885 CCT2 854664 CCT2 Saccharomyces cerevisiae Cct2p NP_012124.1 83302 D 4932 CDS NP_012126.1 6322051 854666 85366..87837 1 NC_001141.1 Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate; Axl2p 87837 AXL2 854666 AXL2 Saccharomyces cerevisiae Axl2p NP_012126.1 85366 D 4932 CDS NP_012127.1 6322052 854667 complement(87979..88716) 1 NC_001141.1 Rev7p; Processivity subunit of DNA polymerase zeta, which is involved in DNA repair and translesion synthesis; required for mutagenesis induced by DNA damage 88716 REV7 854667 REV7 Saccharomyces cerevisiae Processivity subunit of DNA polymerase zeta, which is involved in DNA repair and translesion synthesis; required for mutagenesis induced by DNA damage NP_012127.1 87979 R 4932 CDS NP_012128.1 6322053 854668 complement(89230..89715) 1 NC_001141.1 Tpm2p; Minor isoform of tropomyosin, binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p 89715 TPM2 854668 TPM2 Saccharomyces cerevisiae Minor isoform of tropomyosin, binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p NP_012128.1 89230 R 4932 CDS NP_012129.1 6322054 854669 complement(89948..92788) 1 NC_001141.1 Tma108p; Protein that associates with ribosomes; putative metalloprotease 92788 TMA108 854669 TMA108 Saccharomyces cerevisiae Protein that associates with ribosomes; putative metalloprotease NP_012129.1 89948 R 4932 CDS NP_012130.1 6322055 854670 93619..94800 1 NC_001141.1 Protein of unknown function, major constituent of the mitochondrial outer membrane; located on the outer (cytosolic) face of the outer membrane; Om45p 94800 OM45 854670 OM45 Saccharomyces cerevisiae Om45p NP_012130.1 93619 D 4932 CDS NP_012131.1 6322056 854671 complement(95065..96375) 1 NC_001141.1 Vhs2p; Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p 96375 VHS2 854671 VHS2 Saccharomyces cerevisiae Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p NP_012131.1 95065 R 4932 CDS NP_878096.1 33438814 1466491 complement(96522..96725) 1 NC_001141.1 Yil134c-ap; Putative protein of unknown function, identified by fungal homology and RT-PCR 96725 1466491 YIL134C-A Saccharomyces cerevisiae Putative protein of unknown function, identified by fungal homology and RT-PCR NP_878096.1 96522 R 4932 CDS NP_012132.1 6322057 854672 97395..98330 1 NC_001141.1 Protein required for transport of flavin adenine dinucleotide (FAD), a synthesis product of riboflavin, across the mitochondrial membrane; Flx1p 98330 FLX1 854672 FLX1 Saccharomyces cerevisiae Flx1p NP_012132.1 97395 D 4932 CDS NP_012133.1 6322058 854673 complement(join(98527..99095,99386..99416)) 1 NC_001141.1 Rpl16ap; N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p 99416 RPL16A 854673 RPL16A Saccharomyces cerevisiae N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p NP_012133.1 98527 R 4932 CDS NP_012134.1 6322059 854674 complement(99860..100501) 1 NC_001141.1 Protein required for accurate chromosome segregation during meiosis; Csm2p 100501 CSM2 854674 CSM2 Saccharomyces cerevisiae Csm2p NP_012134.1 99860 R 4932 CDS NP_012135.1 6322060 854675 complement(100781..102235) 1 NC_001141.1 Forkhead family transcription factor with a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; regulates donor preference during switching; Fkh1p 102235 FKH1 854675 FKH1 Saccharomyces cerevisiae Fkh1p NP_012135.1 100781 R 4932 CDS NP_012136.1 6322061 854676 102782..105676 1 NC_001141.1 Proposed transcriptional activator, member of the Gal4p family of zinc cluster proteins; Asg1p 105676 ASG1 854676 ASG1 Saccharomyces cerevisiae Asg1p NP_012136.1 102782 D 4932 CDS NP_012137.1 6322062 854677 complement(106107..113237) 1 NC_001141.1 Tao3p; Protein involved in cell morphogenesis and proliferation, associated with protein kinase Cbk1p; mutants activate OCH1 transcription 113237 TAO3 854677 TAO3 Saccharomyces cerevisiae Protein involved in cell morphogenesis and proliferation, associated with protein kinase Cbk1p; mutants activate OCH1 transcription NP_012137.1 106107 R 4932 CDS NP_012138.1 6322063 854678 113806..116904 1 NC_001141.1 Met18p; DNA repair and TFIIH regulator, required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription; involved in telomere maintenance 116904 MET18 854678 MET18 Saccharomyces cerevisiae DNA repair and TFIIH regulator, required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription; involved in telomere maintenance NP_012138.1 113806 D 4932 CDS NP_012139.1 6322064 854679 complement(117024..117644) 1 NC_001141.1 Yil127cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus 117644 854679 YIL127C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus NP_012139.1 117024 R 4932 CDS NP_012140.1 6322065 854680 117992..122071 1 NC_001141.1 Sth1p; ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p 122071 STH1 854680 STH1 Saccharomyces cerevisiae ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p NP_012140.1 117992 D 4932 CDS NP_012141.1 6322066 854681 122689..125733 1 NC_001141.1 Kgd1p; Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA 125733 KGD1 854681 KGD1 Saccharomyces cerevisiae Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA NP_012141.1 122689 D 4932 CDS NP_012142.1 6322067 854682 126204..127097 1 NC_001141.1 NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones; Ayr1p 127097 AYR1 854682 AYR1 Saccharomyces cerevisiae Ayr1p NP_012142.1 126204 D 4932 CDS NP_012143.1 6322068 854683 128151..129578 1 NC_001141.1 Sim1p; Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated 129578 SIM1 854683 SIM1 Saccharomyces cerevisiae Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated NP_012143.1 128151 D 4932 CDS NP_012144.1 6322069 854684 130607..131662 1 NC_001141.1 Putative transcriptional activator that promotes recovery from pheromone induced arrest; inhibits both alpha-factor induced G1 arrest and repression of CLN1 and CLN2 via SCB/MCB promoter elements; potential Cdc28p substrate; SBF regulated; Pog1p 131662 POG1 854684 POG1 Saccharomyces cerevisiae Pog1p NP_012144.1 130607 D 4932 CDS NP_012145.1 6322070 854685 132241..133869 1 NC_001141.1 Qdr2p; Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, barban, cisplatin, and bleomycin; may have a role in potassium uptake 133869 QDR2 854685 QDR2 Saccharomyces cerevisiae Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, barban, cisplatin, and bleomycin; may have a role in potassium uptake NP_012145.1 132241 D 4932 CDS NP_012146.1 6322071 854686 134414..136105 1 NC_001141.1 Qdr1p; Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, ketoconazole, fluconazole, and barban 136105 QDR1 854686 QDR1 Saccharomyces cerevisiae Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, ketoconazole, fluconazole, and barban NP_012146.1 134414 D 4932 CDS NP_012147.1 6322072 854687 complement(136651..137874) 1 NC_001141.1 Rpi1p; Putative transcriptional regulator; overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutation 137874 RPI1 854687 RPI1 Saccharomyces cerevisiae Putative transcriptional regulator; overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutation NP_012147.1 136651 R 4932 CDS NP_012148.1 6322073 854688 139749..140444 1 NC_001141.1 Rho3p; Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p 140444 RHO3 854688 RHO3 Saccharomyces cerevisiae Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p NP_012148.1 139749 D 4932 CDS NP_012149.1 6322074 854689 complement(140610..141566) 1 NC_001141.1 Prm5p; Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling 141566 PRM5 854689 PRM5 Saccharomyces cerevisiae Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling NP_012149.1 140610 R 4932 CDS NP_012150.1 6322075 854690 142925..144082 1 NC_001141.1 Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; His5p 144082 HIS5 854690 HIS5 Saccharomyces cerevisiae His5p NP_012150.1 142925 D 4932 CDS NP_012151.1 6322076 854691 complement(144324..148706) 1 NC_001141.1 Nup159p; Nucleoporin, subunit of the nuclear pore complex that is found exclusively on the cytoplasmic side, forms a subcomplex with Nup82p and Nsp1p, required for mRNA export 148706 NUP159 854691 NUP159 Saccharomyces cerevisiae Nucleoporin, subunit of the nuclear pore complex that is found exclusively on the cytoplasmic side, forms a subcomplex with Nup82p and Nsp1p, required for mRNA export NP_012151.1 144324 R 4932 CDS NP_012152.1 6322077 854692 complement(149140..149985) 1 NC_001141.1 Putative mitochondrial porin (voltage-dependent anion channel), related to Por1p but not required for mitochondrial membrane permeability or mitochondrial osmotic stability; Por2p 149985 POR2 854692 POR2 Saccharomyces cerevisiae Por2p NP_012152.1 149140 R 4932 CDS NP_012153.1 6322078 854693 150556..151185 1 NC_001141.1 Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock; Sdp1p 151185 SDP1 854693 SDP1 Saccharomyces cerevisiae Sdp1p NP_012153.1 150556 D 4932 CDS NP_012154.1 6322079 854694 151592..154843 1 NC_001141.1 Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate; Hos4p 154843 HOS4 854694 HOS4 Saccharomyces cerevisiae Hos4p NP_012154.1 151592 D 4932 CDS NP_012155.1 6322080 854695 join(155219,155308..155762) 1 NC_001141.1 Subunit Vb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; Cox5bp 155762 COX5B 854695 COX5B Saccharomyces cerevisiae Cox5bp NP_012155.1 155219 D 4932 CDS NP_012156.1 6322081 854696 156042..157175 1 NC_001141.1 Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; deletion mutant exhibits a weak vacuolar protein sorting defect, enhanced resistance to caspofungin, and is synthetically lethal with MEN mutants; Mni1p 157175 MNI1 854696 MNI1 Saccharomyces cerevisiae Mni1p NP_012156.1 156042 D 4932 CDS NP_012157.1 6322082 854697 complement(157382..160162) 1 NC_001141.1 Sec24p; Component of the Sec23p-Sec24p heterodimeric complex of the COPII vesicle coat; involved in ER to Golgi transport, cargo selection and autophagy; required for the binding of the Sec13 complex to ER membranes; homologous to Lst1p and Lss1p 160162 SEC24 854697 SEC24 Saccharomyces cerevisiae Component of the Sec23p-Sec24p heterodimeric complex of the COPII vesicle coat; involved in ER to Golgi transport, cargo selection and autophagy; required for the binding of the Sec13 complex to ER membranes; homologous to Lst1p and Lss1p NP_012157.1 157382 R 4932 CDS NP_012158.1 6322083 854698 160884..162974 1 NC_001141.1 Yil108wp; Putative metalloprotease 162974 854698 YIL108W Saccharomyces cerevisiae Putative metalloprotease NP_012158.1 160884 D 4932 CDS NP_012159.1 6322084 854699 complement(163275..165758) 1 NC_001141.1 Pfk26p; 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, has negligible fructose-2,6-bisphosphatase activity, transcriptional regulation involves protein kinase A 165758 PFK26 854699 PFK26 Saccharomyces cerevisiae 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, has negligible fructose-2,6-bisphosphatase activity, transcriptional regulation involves protein kinase A NP_012159.1 163275 R 4932 CDS NP_012160.2 6681848 854700 join(166412..166431,166517..167441) 1 NC_001141.1 Mob1p; Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex 167441 MOB1 854700 MOB1 Saccharomyces cerevisiae Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex NP_012160.2 166412 D 4932 CDS NP_012161.1 6322086 854701 complement(167578..169638) 1 NC_001141.1 Slm1p; Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; subunit of and phosphorylated by the TORC2 complex 169638 SLM1 854701 SLM1 Saccharomyces cerevisiae Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; subunit of and phosphorylated by the TORC2 complex NP_012161.1 167578 R 4932 CDS NP_012162.1 6322087 854702 complement(169979..171502) 1 NC_001141.1 Shq1p; Essential nuclear protein, required for accumulation of box H/ACA snoRNAs and for rRNA processing; interacts with Naf1p 171502 SHQ1 854702 SHQ1 Saccharomyces cerevisiae Essential nuclear protein, required for accumulation of box H/ACA snoRNAs and for rRNA processing; interacts with Naf1p NP_012162.1 169979 R 4932 CDS NP_012163.1 6322088 854703 171748..173025 1 NC_001141.1 Protein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11p; Dph1p 173025 DPH1 854703 DPH1 Saccharomyces cerevisiae Dph1p NP_012163.1 171748 D 4932 CDS NP_001032579.1 82795255 3799974 complement(173362..173589) 1 NC_001141.1 Yil102c-ap; Putative protein of unknown function, identified based on comparisons of the genome sequences of six Saccharomyces species 173589 3799974 YIL102C-A Saccharomyces cerevisiae Putative protein of unknown function, identified based on comparisons of the genome sequences of six Saccharomyces species NP_001032579.1 173362 R 4932 CDS NP_012164.1 6322089 854704 complement(174579..174884) 1 NC_001141.1 Yil102cp; Putative protein of unknown function 174884 854704 YIL102C Saccharomyces cerevisiae Putative protein of unknown function NP_012164.1 174579 R 4932 CDS NP_012165.1 6322090 854706 complement(175304..177247) 1 NC_001141.1 Xbp1p; Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate 177247 XBP1 854706 XBP1 Saccharomyces cerevisiae Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate NP_012165.1 175304 R 4932 CDS NP_012167.1 6322092 854708 178001..179650 1 NC_001141.1 Sga1p; Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation 179650 SGA1 854708 SGA1 Saccharomyces cerevisiae Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation NP_012167.1 178001 D 4932 CDS NP_012168.1 6322093 854709 complement(179769..180236) 1 NC_001141.1 Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p; Fmc1p 180236 FMC1 854709 FMC1 Saccharomyces cerevisiae Fmc1p NP_012168.1 179769 R 4932 CDS NP_012169.1 6322094 854710 180424..181974 1 NC_001141.1 Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains CTLH domain; Fyv10p 181974 FYV10 854710 FYV10 Saccharomyces cerevisiae Fyv10p NP_012169.1 180424 D 4932 CDS NP_012170.1 6322095 854711 complement(182114..183124) 1 NC_001141.1 Yil096cp; Putative protein of unknown function; associates with precursors of the 60S ribosomal subunit 183124 854711 YIL096C Saccharomyces cerevisiae Putative protein of unknown function; associates with precursors of the 60S ribosomal subunit NP_012170.1 182114 R 4932 CDS NP_012171.1 6322096 854713 183934..186366 1 NC_001141.1 Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton through the phosphorylation of the Pan1p-Sla1p-End3p protein complex; Prk1p 186366 PRK1 854713 PRK1 Saccharomyces cerevisiae Prk1p NP_012171.1 183934 D 4932 CDS NP_012172.1 6322097 854714 complement(186514..187629) 1 NC_001141.1 Lys12p; Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate 187629 LYS12 854714 LYS12 Saccharomyces cerevisiae Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate NP_012172.1 186514 R 4932 CDS NP_012173.1 6322098 854715 complement(187987..188781) 1 NC_001141.1 Rsm25p; Mitochondrial ribosomal protein of the small subunit 188781 RSM25 854715 RSM25 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the small subunit NP_012173.1 187987 R 4932 CDS NP_012174.1 6322099 854716 189063..190964 1 NC_001141.1 Yil092wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus 190964 854716 YIL092W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus NP_012174.1 189063 D 4932 CDS NP_012175.1 6322100 854717 complement(191027..193192) 1 NC_001141.1 Yil091cp; Protein required for cell viability 193192 854717 YIL091C Saccharomyces cerevisiae Protein required for cell viability NP_012175.1 191027 R 4932 CDS NP_012176.1 6322101 854718 193592..195067 1 NC_001141.1 Integral ER membrane protein with type-III transmembrane domains; mutations cause defects in cortical ER morphology in both the mother and daughter cells; Ice2p 195067 ICE2 854718 ICE2 Saccharomyces cerevisiae Ice2p NP_012176.1 193592 D 4932 CDS NP_012177.1 6322102 854719 195596..196213 1 NC_001141.1 Yil089wp; Putative protein of unknown function 196213 854719 YIL089W Saccharomyces cerevisiae Putative protein of unknown function NP_012177.1 195596 D 4932 CDS NP_012178.1 6322103 854721 complement(197928..199400) 1 NC_001141.1 Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; Avt7p 199400 AVT7 854721 AVT7 Saccharomyces cerevisiae Avt7p NP_012178.1 197928 R 4932 CDS NP_012179.1 6322104 854722 complement(199643..200116) 1 NC_001141.1 Putative protein of unknown function; protein is detected in purified mitochondria in high-throughput studies; null mutant displays decreased mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media; Lrc2p 200116 LRC2 854722 LRC2 Saccharomyces cerevisiae Lrc2p NP_012179.1 199643 R 4932 CDS NP_012181.1 6322106 854724 complement(200487..202040) 1 NC_001141.1 Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Ktr7p 202040 KTR7 854724 KTR7 Saccharomyces cerevisiae Ktr7p NP_012181.1 200487 R 4932 CDS NP_012182.1 6322107 854725 complement(202273..203256) 1 NC_001141.1 Sds3p; Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes 203256 SDS3 854725 SDS3 Saccharomyces cerevisiae Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes NP_012182.1 202273 R 4932 CDS NP_012183.1 6322108 854726 complement(203553..204650) 1 NC_001141.1 Yil083cp; Putative phosphopantothenoylcysteine synthetase (PPCS) that catalyzes the second step in the biosynthesis of coenzyme A from pantothenate; conserved in bacteria, humans, and plants; essential for viability 204650 854726 YIL083C Saccharomyces cerevisiae Putative phosphopantothenoylcysteine synthetase (PPCS) that catalyzes the second step in the biosynthesis of coenzyme A from pantothenate; conserved in bacteria, humans, and plants; essential for viability NP_012183.1 203553 R 4932 CDS NP_012184.1 6322110 854728 join(205632..206482,206484..210129) 1 NC_001141.1 Yil082w-ap; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 210129 854728 YIL082W-A Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_012184.1 205632 D 4932 CDS NP_012186.1 6322111 854731 complement(210920..212002) 1 NC_001141.1 RING finger protein that interacts with the arginine methyltransferase Hmt1p to regulate methylation of Npl3p, which modulates Npl3p function in mRNA processing and export; has similarity to Air2p; Air1p 212002 AIR1 854731 AIR1 Saccharomyces cerevisiae Air1p NP_012186.1 210920 R 4932 CDS NP_116578.1 14318437 854732 212496..214700 1 NC_001141.1 Ths1p; Threonyl-tRNA synthetase, essential cytoplasmic protein 214700 THS1 854732 THS1 Saccharomyces cerevisiae Threonyl-tRNA synthetase, essential cytoplasmic protein NP_116578.1 212496 D 4932 CDS NP_012188.1 6322113 854733 complement(214988..215950) 1 NC_001141.1 Yil077cp; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) 215950 854733 YIL077C Saccharomyces cerevisiae Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) NP_012188.1 214988 R 4932 CDS NP_012189.2 82795256 854734 216655..217545 1 NC_001141.1 Sec28p; Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth 217545 SEC28 854734 SEC28 Saccharomyces cerevisiae Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth NP_012189.2 216655 D 4932 CDS NP_012190.1 6322115 854735 complement(217860..220697) 1 NC_001141.1 Subunit of the 26S proteasome, substrate of the N-acetyltransferase Nat1p; Rpn2p 220697 RPN2 854735 RPN2 Saccharomyces cerevisiae Rpn2p NP_012190.1 217860 R 4932 CDS NP_012191.1 6322116 854736 complement(221078..222487) 1 NC_001141.1 Ser33p; 3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser3p 222487 SER33 854736 SER33 Saccharomyces cerevisiae 3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser3p NP_012191.1 221078 R 4932 CDS NP_012192.2 37362662 854737 complement(join(222934..225806,225897..225951)) 1 NC_001141.1 Spo22p; Meiosis-specific protein essential for chromosome synapsis, similar to phospholipase A2, involved in completion of nuclear divisions during meiosis; induced early in meiosis 225951 SPO22 854737 SPO22 Saccharomyces cerevisiae Meiosis-specific protein essential for chromosome synapsis, similar to phospholipase A2, involved in completion of nuclear divisions during meiosis; induced early in meiosis NP_012192.2 222934 R 4932 CDS NP_012193.1 6322118 854738 226599..228416 1 NC_001141.1 Meiosis-specific DNA binding protein that displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for homologous chromosome synapsis and chiasma formation; Hop1p 228416 HOP1 854738 HOP1 Saccharomyces cerevisiae Hop1p NP_012193.1 226599 D 4932 CDS NP_085069.1 13432314 854739 complement(228657..229991) 1 NC_001141.1 Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain; Pci8p 229991 PCI8 854739 PCI8 Saccharomyces cerevisiae Pci8p NP_085069.1 228657 R 4932 CDS NP_012194.1 6322119 854740 complement(230269..231069) 1 NC_001141.1 Mam33p; Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R 231069 MAM33 854740 MAM33 Saccharomyces cerevisiae Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R NP_012194.1 230269 R 4932 CDS NP_012195.1 6322120 854741 complement(join(231550..231954,232364..232366)) 1 NC_001141.1 Rps24bp; Protein component of the small (40S) ribosomal subunit; identical to Rps24Ap and has similarity to rat S24 ribosomal protein 232366 RPS24B 854741 RPS24B Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit; identical to Rps24Ap and has similarity to rat S24 ribosomal protein NP_012195.1 231550 R 4932 CDS NP_012196.1 6322121 854742 complement(233054..235471) 1 NC_001141.1 Sec6p; Essential 88kDa subunit of the exocyst complex, which mediates polarized targeting of secretory vesicles to active sites of exocytosis; dimeric form of Sec6p interacts with Sec9p in vitro and inhibits t-SNARE assembly 235471 SEC6 854742 SEC6 Saccharomyces cerevisiae Essential 88kDa subunit of the exocyst complex, which mediates polarized targeting of secretory vesicles to active sites of exocytosis; dimeric form of Sec6p interacts with Sec9p in vitro and inhibits t-SNARE assembly NP_012196.1 233054 R 4932 CDS NP_012197.1 6322122 854743 complement(235721..237757) 1 NC_001141.1 Yil067cp; Uncharacterized protein of unknown function 237757 854743 YIL067C Saccharomyces cerevisiae Uncharacterized protein of unknown function NP_012197.1 235721 R 4932 CDS NP_012198.1 6322123 854744 complement(238096..240705) 1 NC_001141.1 Rnr3p; Ribonucleotide-diphosphate reductase (RNR), large subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits 240705 RNR3 854744 RNR3 Saccharomyces cerevisiae Ribonucleotide-diphosphate reductase (RNR), large subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits NP_012198.1 238096 R 4932 CDS NP_012199.1 6322124 854745 complement(241305..241772) 1 NC_001141.1 Mitochondrial outer membrane protein involved in membrane fission, required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation; Fis1p 241772 FIS1 854745 FIS1 Saccharomyces cerevisiae Fis1p NP_012199.1 241305 R 4932 CDS NP_012200.1 6322125 854746 241940..242713 1 NC_001141.1 Yil064wp; Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family 242713 854746 YIL064W Saccharomyces cerevisiae Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family NP_012200.1 241940 D 4932 CDS NP_012201.1 6322126 854747 complement(242758..243741) 1 NC_001141.1 Yrb2p; Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essential 243741 YRB2 854747 YRB2 Saccharomyces cerevisiae Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essential NP_012201.1 242758 R 4932 CDS NP_012202.1 6322127 854748 complement(243995..244459) 1 NC_001141.1 Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; Arc15p 244459 ARC15 854748 ARC15 Saccharomyces cerevisiae Arc15p NP_012202.1 243995 R 4932 CDS NP_012203.1 6322128 854749 complement(244654..245556) 1 NC_001141.1 Snp1p; Component of U1 snRNP required for mRNA splicing via spliceosome; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein 245556 SNP1 854749 SNP1 Saccharomyces cerevisiae Component of U1 snRNP required for mRNA splicing via spliceosome; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein NP_012203.1 244654 R 4932 CDS NP_012204.1 6322129 854750 246389..246823 1 NC_001141.1 Yil060wp; Putative protein of unknown function; mutant accumulates less glycogen than does wild type; YIL060W is not an essential gene 246823 854750 YIL060W Saccharomyces cerevisiae Putative protein of unknown function; mutant accumulates less glycogen than does wild type; YIL060W is not an essential gene NP_012204.1 246389 D 4932 CDS NP_012207.1 6322132 854753 complement(247899..248393) 1 NC_001141.1 Yil057cp; Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose 248393 854753 YIL057C Saccharomyces cerevisiae Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose NP_012207.1 247899 R 4932 CDS NP_012208.1 6322133 854755 249989..251911 1 NC_001141.1 Vhr1p; Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations 251911 VHR1 854755 VHR1 Saccharomyces cerevisiae Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations NP_012208.1 249989 D 4932 CDS NP_012209.1 6322134 854756 complement(252040..253923) 1 NC_001141.1 Yil055cp; Putative protein of unknown function 253923 854756 YIL055C Saccharomyces cerevisiae Putative protein of unknown function NP_012209.1 252040 R 4932 CDS NP_012211.2 86558907 854758 255113..255865 1 NC_001141.1 Rhr2p; Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress 255865 RHR2 854758 RHR2 Saccharomyces cerevisiae Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress NP_012211.2 255113 D 4932 CDS NP_012212.1 6322137 854759 complement(join(256224..256552,257025..257061)) 1 NC_001141.1 Rpl34bp; Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Ap and has similarity to rat L34 ribosomal protein 257061 RPL34B 854759 RPL34B Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Ap and has similarity to rat L34 ribosomal protein NP_012212.1 256224 R 4932 CDS NP_012213.1 6322138 854760 complement(257842..258279) 1 NC_001141.1 Mmf1p; Mitochondrial protein involved in maintenance of the mitochondrial genome 258279 MMF1 854760 MMF1 Saccharomyces cerevisiae Mitochondrial protein involved in maintenance of the mitochondrial genome NP_012213.1 257842 R 4932 CDS NP_012214.1 6322139 854761 258912..259769 1 NC_001141.1 Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated; Pcl7p 259769 PCL7 854761 PCL7 Saccharomyces cerevisiae Pcl7p NP_012214.1 258912 D 4932 CDS NP_012215.1 6322140 854762 260157..260918 1 NC_001141.1 Protein of unknown function, involved in filamentous growth; Dfg10p 260918 DFG10 854762 DFG10 Saccharomyces cerevisiae Dfg10p NP_012215.1 260157 D 4932 CDS NP_012216.1 6322141 854763 261436..264891 1 NC_001141.1 Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus; Neo1p 264891 NEO1 854763 NEO1 Saccharomyces cerevisiae Neo1p NP_012216.1 261436 D 4932 CDS NP_012217.1 6322142 854764 complement(265114..267822) 1 NC_001141.1 Syg1p; Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency 267822 SYG1 854764 SYG1 Saccharomyces cerevisiae Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency NP_012217.1 265114 R 4932 CDS NP_878097.1 33438815 1466492 268308..268472 1 NC_001141.1 Yil046w-ap; Putative protein of unknown function; identified by expression profiling and mass spectrometry 268472 1466492 YIL046W-A Saccharomyces cerevisiae Putative protein of unknown function; identified by expression profiling and mass spectrometry NP_878097.1 268308 D 4932 CDS NP_012218.1 6322143 854765 268650..270572 1 NC_001141.1 Met30p; F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus 270572 MET30 854765 MET30 Saccharomyces cerevisiae F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus NP_012218.1 268650 D 4932 CDS NP_012219.1 6322144 854766 271160..272776 1 NC_001141.1 Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase; Pig2p 272776 PIG2 854766 PIG2 Saccharomyces cerevisiae Pig2p NP_012219.1 271160 D 4932 CDS NP_012220.1 6322145 854767 complement(272949..273845) 1 NC_001141.1 Age2p; ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif 273845 AGE2 854767 AGE2 Saccharomyces cerevisiae ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif NP_012220.1 272949 R 4932 CDS NP_012221.2 86558908 854768 complement(274071..274925) 1 NC_001141.1 Microsomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia; Cbr1p 274925 CBR1 854768 CBR1 Saccharomyces cerevisiae Cbr1p NP_012221.2 274071 R 4932 CDS NP_012222.1 6322147 854769 complement(275107..276291) 1 NC_001141.1 Pkp1p; Mitochondrial kinase, phosphorylates pyruvate dehydrogenase alpha subunit Pda1p 276291 PKP1 854769 PKP1 Saccharomyces cerevisiae Mitochondrial kinase, phosphorylates pyruvate dehydrogenase alpha subunit Pda1p NP_012222.1 275107 R 4932 CDS NP_012223.1 6322148 854770 276524..277504 1 NC_001141.1 Gvp36p; Golgi vesicle protein of unknown function; localizes to both early and late Golgi vesicles; may interact with ribosomes, based on co-purification experiments 277504 GVP36 854770 GVP36 Saccharomyces cerevisiae Golgi vesicle protein of unknown function; localizes to both early and late Golgi vesicles; may interact with ribosomes, based on co-purification experiments NP_012223.1 276524 D 4932 CDS NP_012224.1 6322149 854771 277722..278138 1 NC_001141.1 Protein involved in nucleocytoplasmic transport of mRNA; Apq12p 278138 APQ12 854771 APQ12 Saccharomyces cerevisiae Apq12p NP_012224.1 277722 D 4932 CDS NP_012225.1 6322150 854772 278425..279846 1 NC_001141.1 Ted1p; Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) 279846 TED1 854772 TED1 Saccharomyces cerevisiae Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) NP_012225.1 278425 D 4932 CDS NP_012226.1 6322151 854773 complement(280141..282651) 1 NC_001141.1 Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation; Not3p 282651 NOT3 854773 NOT3 Saccharomyces cerevisiae Not3p NP_012226.1 280141 R 4932 CDS NP_012227.1 6322152 854774 complement(283028..284998) 1 NC_001141.1 Prm2p; Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p 284998 PRM2 854774 PRM2 Saccharomyces cerevisiae Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p NP_012227.1 283028 R 4932 CDS NP_012228.1 6322153 854775 285665..287428 1 NC_001141.1 Cst6p; Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, activates transcription of genes involved in utilization of non-optimal carbon sources; involved in telomere maintenance 287428 CST6 854775 CST6 Saccharomyces cerevisiae Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, activates transcription of genes involved in utilization of non-optimal carbon sources; involved in telomere maintenance NP_012228.1 285665 D 4932 CDS NP_012229.1 6322154 854776 complement(287789..288907) 1 NC_001141.1 Cka1p; Alpha catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA2, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases 288907 CKA1 854776 CKA1 Saccharomyces cerevisiae Alpha catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA2, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases NP_012229.1 287789 R 4932 CDS NP_012230.1 6322155 854777 complement(289225..290088) 1 NC_001141.1 Cap2p; Beta subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches 290088 CAP2 854777 CAP2 Saccharomyces cerevisiae Beta subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches NP_012230.1 289225 R 4932 CDS NP_012231.1 6322156 854778 complement(290418..291668) 1 NC_001141.1 Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA), a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation; Bcy1p 291668 BCY1 854778 BCY1 Saccharomyces cerevisiae Bcy1p NP_012231.1 290418 R 4932 CDS NP_012233.1 6322158 854780 292632..295736 1 NC_001141.1 Ulp2p; Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate 295736 ULP2 854780 ULP2 Saccharomyces cerevisiae Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate NP_012233.1 292632 D 4932 CDS NP_012234.1 6322159 854781 complement(296049..300008) 1 NC_001141.1 Ubiquitin-protein ligase of the ER/nuclear envelope, required for degradation of Alpha2p and other proteins containing a Deg1 degradation signal; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation; Ssm4p 300008 SSM4 854781 SSM4 Saccharomyces cerevisiae Ssm4p NP_012234.1 296049 R 4932 CDS NP_012235.1 6322160 854783 complement(300827..301255) 1 NC_001141.1 Yil029cp; Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) 301255 854783 YIL029C Saccharomyces cerevisiae Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) NP_012235.1 300827 R 4932 CDS NP_012237.1 6322162 854785 complement(303677..304102) 1 NC_001141.1 Protein of unknown function; null mutant shows K1 killer toxin resistance; Kre27p 304102 KRE27 854785 KRE27 Saccharomyces cerevisiae Kre27p NP_012237.1 303677 R 4932 CDS NP_012238.1 6322163 854786 complement(304475..307927) 1 NC_001141.1 Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability; Irr1p 307927 IRR1 854786 IRR1 Saccharomyces cerevisiae Irr1p NP_012238.1 304475 R 4932 CDS NP_012240.1 6322165 854788 complement(308600..309169) 1 NC_001141.1 Yil024cp; Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p 309169 854788 YIL024C Saccharomyces cerevisiae Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p NP_012240.1 308600 R 4932 CDS NP_012241.1 6322166 854789 complement(309384..310424) 1 NC_001141.1 Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family; Yke4p 310424 YKE4 854789 YKE4 Saccharomyces cerevisiae Yke4p NP_012241.1 309384 R 4932 CDS NP_012242.1 6322167 854790 311163..312458 1 NC_001141.1 Tim44p; Peripheral mitochondrial membrane protein involved in mitochondrial protein import, tethers essential chaperone Ssc1p to the translocon channel at the matrix side of the inner membrane 312458 TIM44 854790 TIM44 Saccharomyces cerevisiae Peripheral mitochondrial membrane protein involved in mitochondrial protein import, tethers essential chaperone Ssc1p to the translocon channel at the matrix side of the inner membrane NP_012242.1 311163 D 4932 CDS NP_012243.1 6322168 854791 312903..313859 1 NC_001141.1 Rpb3p; RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit 313859 RPB3 854791 RPB3 Saccharomyces cerevisiae RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit NP_012243.1 312903 D 4932 CDS NP_012244.1 6322169 854792 complement(314033..314818) 1 NC_001141.1 Phosphoribosyl-5-amino-1-phosphoribosyl-4- imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; His6p 314818 HIS6 854792 HIS6 Saccharomyces cerevisiae His6p NP_012244.1 314033 R 4932 CDS NP_012245.1 6322170 854793 315091..316131 1 NC_001141.1 Protein required for pre-rRNA processing and 40S ribosomal subunit assembly; Faf1p 316131 FAF1 854793 FAF1 Saccharomyces cerevisiae Faf1p NP_012245.1 315091 D 4932 CDS NP_012246.1 6322171 854794 join(316766..316769,317170..317930) 1 NC_001141.1 Rpl2bp; Protein component of the large (60S) ribosomal subunit, identical to Rpl2Ap and has similarity to E. coli L2 and rat L8 ribosomal proteins; expression is upregulated at low temperatures 317930 RPL2B 854794 RPL2B Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, identical to Rpl2Ap and has similarity to E. coli L2 and rat L8 ribosomal proteins; expression is upregulated at low temperatures NP_012246.1 316766 D 4932 CDS NP_012247.1 6322172 854795 complement(318198..320963) 1 NC_001141.1 Vid28p; Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm 320963 VID28 854795 VID28 Saccharomyces cerevisiae Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm NP_012247.1 318198 R 4932 CDS NP_012248.1 6322173 854796 321452..321931 1 NC_001141.1 Snl1p; Protein of unknown function proposed to be involved in nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein 321931 SNL1 854796 SNL1 Saccharomyces cerevisiae Protein of unknown function proposed to be involved in nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein NP_012248.1 321452 D 4932 CDS NP_012249.1 6322174 854797 322340..324103 1 NC_001141.1 Bar1p; Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest 324103 BAR1 854797 BAR1 Saccharomyces cerevisiae Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest NP_012249.1 322340 D 4932 CDS NP_012250.1 6322175 854799 complement(325210..325524) 1 NC_001141.1 Yil014c-ap; Putative protein of unknown function 325524 854799 YIL014C-A Saccharomyces cerevisiae Putative protein of unknown function NP_012250.1 325210 R 4932 CDS NP_012251.1 6322176 854801 326101..327993 1 NC_001141.1 Mnt3p; Alpha-1,3-mannosyltransferase, adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation 327993 MNT3 854801 MNT3 Saccharomyces cerevisiae Alpha-1,3-mannosyltransferase, adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation NP_012251.1 326101 D 4932 CDS NP_012252.1 6322177 854802 complement(328205..332440) 1 NC_001141.1 Pdr11p; ATP-binding cassette (ABC) transporter, multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromisedregulated by Pdr1p; required for anaerobic growth 332440 PDR11 854802 PDR11 Saccharomyces cerevisiae ATP-binding cassette (ABC) transporter, multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromisedregulated by Pdr1p; required for anaerobic growth NP_012252.1 328205 R 4932 CDS NP_012254.1 6322179 854804 333724..334533 1 NC_001141.1 Tir3p; Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth 334533 TIR3 854804 TIR3 Saccharomyces cerevisiae Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth NP_012254.1 333724 D 4932 CDS NP_012255.1 6322180 854805 334879..335526 1 NC_001141.1 Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth; Dot5p 335526 DOT5 854805 DOT5 Saccharomyces cerevisiae Dot5p NP_012255.1 334879 D 4932 CDS NP_012256.1 6322181 854806 complement(join(335663..335932,335934..336209)) 1 NC_001141.1 Est3p; Component of the telomerase holoenzyme, involved in telomere replication 336209 EST3 854806 EST3 Saccharomyces cerevisiae Component of the telomerase holoenzyme, involved in telomere replication NP_012256.1 335663 R 4932 CDS NP_012257.1 6322182 854808 339341..341425 1 NC_001141.1 Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; Faa3p 341425 FAA3 854808 FAA3 Saccharomyces cerevisiae Faa3p NP_012257.1 339341 D 4932 CDS NP_012258.1 6322183 854809 342533..342832 1 NC_001141.1 Urm1p; Ubiquitin-like protein with weak sequence similarity to ubiquitin; depends on the E1-like activating enzyme Uba4p; molecular function of the Urm1p pathway is unknown, but it is required for normal growth, particularly at high temperature 342832 URM1 854809 URM1 Saccharomyces cerevisiae Ubiquitin-like protein with weak sequence similarity to ubiquitin; depends on the E1-like activating enzyme Uba4p; molecular function of the Urm1p pathway is unknown, but it is required for normal growth, particularly at high temperature NP_012258.1 342533 D 4932 CDS NP_012259.1 6322184 854810 complement(342991..343653) 1 NC_001141.1 Protein with similarity to the p27 subunit of mammalian proteasome modulator; not essential; interacts with Rpn4p; Nas2p 343653 NAS2 854810 NAS2 Saccharomyces cerevisiae Nas2p NP_012259.1 342991 R 4932 CDS NP_012260.1 6322185 854811 344059..345180 1 NC_001141.1 Yia6p; Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs 345180 YIA6 854811 YIA6 Saccharomyces cerevisiae Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs NP_012260.1 344059 D 4932 CDS NP_012261.1 6322186 854812 345689..347794 1 NC_001141.1 Eps1p; ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family 347794 EPS1 854812 EPS1 Saccharomyces cerevisiae ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family NP_012261.1 345689 D 4932 CDS NP_012262.1 6322187 854813 complement(join(347943..348360,348492..348502)) 1 NC_001141.1 Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins; Bet1p 348502 BET1 854813 BET1 Saccharomyces cerevisiae Bet1p NP_012262.1 347943 R 4932 CDS NP_012263.1 6322188 854814 349119..350000 1 NC_001141.1 Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol; Cfd1p 350000 CFD1 854814 CFD1 Saccharomyces cerevisiae Cfd1p NP_012263.1 349119 D 4932 CDS NP_878098.1 33438816 1466493 350298..350507 1 NC_001141.1 Yil002w-ap; Putative protein of unknown function; identified by expression profiling and mass spectrometry 350507 1466493 YIL002W-A Saccharomyces cerevisiae Putative protein of unknown function; identified by expression profiling and mass spectrometry NP_878098.1 350298 D 4932 CDS NP_012264.1 6322189 854815 complement(350588..353428) 1 NC_001141.1 Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth; Inp51p 353428 INP51 854815 INP51 Saccharomyces cerevisiae Inp51p NP_012264.1 350588 R 4932 CDS NP_012265.1 6322190 854816 353937..355478 1 NC_001141.1 Yil001wp 355478 854816 YIL001W Saccharomyces cerevisiae Yil001wp NP_012265.1 353937 D 4932 CDS NP_012266.1 6322191 854817 complement(356140..356892) 1 NC_001141.1 Sgn1p; Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation 356892 SGN1 854817 SGN1 Saccharomyces cerevisiae Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation NP_012266.1 356140 R 4932 CDS NP_012267.1 6322192 854818 complement(357412..360393) 1 NC_001141.1 Mph1p; Member of the DEAH family of helicases, functions in an error-free DNA damage bypass pathway that involves homologous recombination, mutations confer a mutator phenotype 360393 MPH1 854818 MPH1 Saccharomyces cerevisiae Member of the DEAH family of helicases, functions in an error-free DNA damage bypass pathway that involves homologous recombination, mutations confer a mutator phenotype NP_012267.1 357412 R 4932 CDS NP_012268.1 6322193 854819 360882..362921 1 NC_001141.1 Protein of unknown function; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton; null mutant displays increased frequency of mitochondrial genome loss (petite formation); Aim21p 362921 AIM21 854819 AIM21 Saccharomyces cerevisiae Aim21p NP_012268.1 360882 D 4932 CDS NP_012269.1 6322194 854820 363218..364516 1 NC_001141.1 Djp1p; Cytosolic J-domain-containing protein, required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ 364516 DJP1 854820 DJP1 Saccharomyces cerevisiae Cytosolic J-domain-containing protein, required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ NP_012269.1 363218 D 4932 CDS NP_012270.1 6322195 854821 364886..365332 1 NC_001141.1 Ist3p; Component of the U2 snRNP, required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing 365332 IST3 854821 IST3 Saccharomyces cerevisiae Component of the U2 snRNP, required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing NP_012270.1 364886 D 4932 CDS NP_012271.1 6322196 854822 complement(365463..369905) 1 NC_001141.1 Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p, associates with actin patches on the cell cortex; promotes protein-protein interactions essential for endocytosis; previously thought to be a subunit of poly(A) ribonuclease; Pan1p 369905 PAN1 854822 PAN1 Saccharomyces cerevisiae Pan1p NP_012271.1 365463 R 4932 CDS NP_012272.1 6322197 854824 370701..372995 1 NC_001141.1 Yir007wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene 372995 854824 YIR007W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene NP_012272.1 370701 D 4932 CDS NP_012273.1 6322198 854825 complement(373074..374303) 1 NC_001141.1 Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair; Pri1p 374303 PRI1 854825 PRI1 Saccharomyces cerevisiae Pri1p NP_012273.1 373074 R 4932 CDS NP_012274.1 6322199 854826 374522..374857 1 NC_001141.1 U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro; does not contain the conserved C-terminal RNA binding domain found in other family members; Msl1p 374857 MSL1 854826 MSL1 Saccharomyces cerevisiae Msl1p NP_012274.1 374522 D 4932 CDS NP_012275.1 6322200 854827 375428..377158 1 NC_001141.1 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation; Dsn1p 377158 DSN1 854827 DSN1 Saccharomyces cerevisiae Dsn1p NP_012275.1 375428 D 4932 CDS NP_012276.1 6322201 854828 complement(377284..378243) 1 NC_001141.1 Sts1p; Protein that interacts with the karyopherin Srp1p; may have a role with Srp1p in ubiquitin-mediated protein degradation 378243 STS1 854828 STS1 Saccharomyces cerevisiae Protein that interacts with the karyopherin Srp1p; may have a role with Srp1p in ubiquitin-mediated protein degradation NP_012276.1 377284 R 4932 CDS NP_012277.1 6322202 854829 378483..379778 1 NC_001141.1 Sqt1p; Essential protein involved in a late step of 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay 379778 SQT1 854829 SQT1 Saccharomyces cerevisiae Essential protein involved in a late step of 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay NP_012277.1 378483 D 4932 CDS NP_012278.1 6322203 854830 complement(380016..380381) 1 NC_001141.1 Protein containing GATA family zinc finger motifs; Gat4p 380381 GAT4 854830 GAT4 Saccharomyces cerevisiae Gat4p NP_012278.1 380016 R 4932 CDS NP_012279.2 37362663 854831 381083..381811 1 NC_001141.1 Yir014wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR014W is a non-essential gene 381811 854831 YIR014W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR014W is a non-essential gene NP_012279.2 381083 D 4932 CDS NP_012280.1 6322205 854832 381945..382379 1 NC_001141.1 Subunit of nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits; Rpr2p 382379 RPR2 854832 RPR2 Saccharomyces cerevisiae Rpr2p NP_012280.1 381945 D 4932 CDS NP_012281.1 6322206 854833 382625..383422 1 NC_001141.1 Yir016wp; Putative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR016W is a non-essential gene 383422 854833 YIR016W Saccharomyces cerevisiae Putative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR016W is a non-essential gene NP_012281.1 382625 D 4932 CDS NP_012282.1 6322207 854834 complement(383553..384116) 1 NC_001141.1 Transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism; Met28p 384116 MET28 854834 MET28 Saccharomyces cerevisiae Met28p NP_012282.1 383553 R 4932 CDS NP_012283.1 6322208 854835 384606..385343 1 NC_001141.1 Yap5p; Basic leucine zipper (bZIP) transcription factor 385343 YAP5 854835 YAP5 Saccharomyces cerevisiae Basic leucine zipper (bZIP) transcription factor NP_012283.1 384606 D 4932 CDS NP_878099.1 33438817 1466494 complement(385561..385698) 1 NC_001141.1 Yir018c-ap; Putative protein of unknown function; identified by expression profiling and mass spectrometry 385698 1466494 YIR018C-A Saccharomyces cerevisiae Putative protein of unknown function; identified by expression profiling and mass spectrometry NP_878099.1 385561 R 4932 CDS NP_012284.1 6322209 854836 complement(389569..393672) 1 NC_001141.1 Muc1p; GPI-anchored cell surface glycoprotein (flocculin) required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p) 393672 MUC1 854836 MUC1 Saccharomyces cerevisiae GPI-anchored cell surface glycoprotein (flocculin) required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p) NP_012284.1 389569 R 4932 CDS NP_012287.1 6322212 854839 397291..398382 1 NC_001141.1 Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA; Mrs1p 398382 MRS1 854839 MRS1 Saccharomyces cerevisiae Mrs1p NP_012287.1 397291 D 4932 CDS NP_878100.1 33438818 1466495 398511..398723 1 NC_001141.1 Yir021w-ap; Putative protein of unknown function; identified by expression profiling and mass spectrometry 398723 1466495 YIR021W-A Saccharomyces cerevisiae Putative protein of unknown function; identified by expression profiling and mass spectrometry NP_878100.1 398511 D 4932 CDS NP_012288.1 6322213 854840 398730..399233 1 NC_001141.1 Sec11p; 18kDa catalytic subunit of the Signal Peptidase Complex (SPC; Spc1p, Spc2p, Spc3p, and Sec11p) which cleaves the signal sequence of proteins targeted to the endoplasmic reticulum 399233 SEC11 854840 SEC11 Saccharomyces cerevisiae 18kDa catalytic subunit of the Signal Peptidase Complex (SPC; Spc1p, Spc2p, Spc3p, and Sec11p) which cleaves the signal sequence of proteins targeted to the endoplasmic reticulum NP_012288.1 398730 D 4932 CDS NP_012289.1 6322214 854841 399774..402686 1 NC_001141.1 Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism; Dal81p 402686 DAL81 854841 DAL81 Saccharomyces cerevisiae Dal81p NP_012289.1 399774 D 4932 CDS NP_012290.1 6322215 854842 complement(402838..403488) 1 NC_001141.1 Yir024cp; Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect 403488 854842 YIR024C Saccharomyces cerevisiae Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect NP_012290.1 402838 R 4932 CDS NP_012291.1 6322216 854843 403656..404762 1 NC_001141.1 Subunit of the anaphase-promoting complex (APC); needed for meiotic nuclear division; Mnd2p 404762 MND2 854843 MND2 Saccharomyces cerevisiae Mnd2p NP_012291.1 403656 D 4932 CDS NP_012292.1 6322217 854844 complement(404870..405964) 1 NC_001141.1 Yvh1p; Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; transcription induced by low temperature and nitrogen starvation; member of the dual-specificity family of protein phosphatases 405964 YVH1 854844 YVH1 Saccharomyces cerevisiae Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; transcription induced by low temperature and nitrogen starvation; member of the dual-specificity family of protein phosphatases NP_012292.1 404870 R 4932 CDS NP_012293.1 6322218 854845 complement(406257..407639) 1 NC_001141.1 Dal1p; Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression 407639 DAL1 854845 DAL1 Saccharomyces cerevisiae Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression NP_012293.1 406257 R 4932 CDS NP_012294.1 6322219 854846 408465..410372 1 NC_001141.1 Dal4p; Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation 410372 DAL4 854846 DAL4 Saccharomyces cerevisiae Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation NP_012294.1 408465 D 4932 CDS NP_012295.1 6322220 854847 410804..411835 1 NC_001141.1 Dal2p; Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation 411835 DAL2 854847 DAL2 Saccharomyces cerevisiae Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation NP_012295.1 410804 D 4932 CDS NP_012296.1 6322221 854848 complement(412033..412767) 1 NC_001141.1 Protein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain; Dcg1p 412767 DCG1 854848 DCG1 Saccharomyces cerevisiae Dcg1p NP_012296.1 412033 R 4932 CDS NP_012297.1 6322222 854849 complement(413012..414676) 1 NC_001141.1 Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; Dal7p 414676 DAL7 854849 DAL7 Saccharomyces cerevisiae Dal7p NP_012297.1 413012 R 4932 CDS NP_012298.1 6322223 854850 complement(415027..415614) 1 NC_001141.1 Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression; Dal3p 415614 DAL3 854850 DAL3 Saccharomyces cerevisiae Dal3p NP_012298.1 415027 R 4932 CDS NP_012299.1 6322224 854851 416121..419462 1 NC_001141.1 Mga2p; ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting 419462 MGA2 854851 MGA2 Saccharomyces cerevisiae ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting NP_012299.1 416121 D 4932 CDS NP_012300.1 6322225 854852 complement(419612..420733) 1 NC_001141.1 Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway; Lys1p 420733 LYS1 854852 LYS1 Saccharomyces cerevisiae Lys1p NP_012300.1 419612 R 4932 CDS NP_012301.1 6322226 854853 complement(421023..421787) 1 NC_001141.1 Yir035cp; Putative cytoplasmic protein of unknown function 421787 854853 YIR035C Saccharomyces cerevisiae Putative cytoplasmic protein of unknown function NP_012301.1 421023 R 4932 CDS NP_012302.1 6322227 854854 complement(422071..422862) 1 NC_001141.1 Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52 foci; Irc24p 422862 IRC24 854854 IRC24 Saccharomyces cerevisiae Irc24p NP_012302.1 422071 R 4932 CDS NP_012303.1 6322228 854855 423125..423616 1 NC_001141.1 Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor; Hyr1p 423616 HYR1 854855 HYR1 Saccharomyces cerevisiae Hyr1p NP_012303.1 423125 D 4932 CDS NP_012304.1 6322229 854856 complement(423806..424510) 1 NC_001141.1 Gtt1p; ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p 424510 GTT1 854856 GTT1 Saccharomyces cerevisiae ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p NP_012304.1 423806 R 4932 CDS NP_012305.1 6322230 854857 complement(430494..432107) 1 NC_001141.1 Yps6p; Putative GPI-anchored aspartic protease 432107 YPS6 854857 YPS6 Saccharomyces cerevisiae Putative GPI-anchored aspartic protease NP_012305.1 430494 R 4932 CDS NP_012307.1 6322232 854859 433925..434299 1 NC_001141.1 Pau15p 434299 PAU15 854859 PAU15 Saccharomyces cerevisiae Pau15p NP_012307.1 433925 D 4932 CDS NP_012308.1 6322233 854860 complement(435270..435980) 1 NC_001141.1 Yir042cp; Putative protein of unknown function; YIR042C is a non-essential gene 435980 854860 YIR042C Saccharomyces cerevisiae Putative protein of unknown function; YIR042C is a non-essential gene NP_012308.1 435270 R 4932 CDS NP_009305.1 6226519 854598 join(13818..13986,16435..16470,18954..18991,20508..20984,21995..22246,23612..23746,25318..25342,26229..26701) 1 NC_001224.1 Subunit I of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits; Cox1p 26701 COX1 854598 COX1 Saccharomyces cerevisiae Cox1p NP_009305.1 13818 D 4932 CDS NP_009306.1 6226524 854597 join(13818..13986,16435..16470,18954..18991,20508..20984,21995..23167) 1 NC_001224.1 Endonuclease I-SceIV, involved in intron mobility; encoded by a mobile group I intron within the mitochondrial COX1 gene; Ai5_alphap 23167 AI5_ALPHA 854597 AI5_ALPHA Saccharomyces cerevisiae Ai5_alphap NP_009306.1 13818 D 4932 CDS NP_009307.2 85666123 854596 join(13818..13986,16435..16470,18954..18991,20508..21935) 1 NC_001224.1 Endonuclease I-SceII, encoded by a mobile group I intron within the mitochondrial COX1 gene; intron is normally spliced by the BI4p maturase but AI4p can mutate to acquire the same maturase activity; Ai4p 21935 AI4 854596 AI4 Saccharomyces cerevisiae Ai4p NP_009307.2 13818 D 4932 CDS NP_009308.2 85666122 854595 join(13818..13986,16435..16470,18954..19996) 1 NC_001224.1 Endonuclease I-SceIII, encoded by a mobile group I intron within the mitochondrial COX1 gene; Ai3p 19996 AI3 854595 AI3 Saccharomyces cerevisiae Ai3p NP_009308.2 13818 D 4932 CDS NP_009309.1 6226521 854594 join(13818..13986,16435..18830) 1 NC_001224.1 Reverse transcriptase required for splicing of the COX1 pre-mRNA, encoded by a mobile group II intron within the mitochondrial COX1 gene; Ai2p 18830 AI2 854594 AI2 Saccharomyces cerevisiae Ai2p NP_009309.1 13818 D 4932 CDS NP_009310.1 6226520 854593 13818..16322 1 NC_001224.1 Reverse transcriptase required for splicing of the COX1 pre-mRNA, encoded by a mobile group II intron within the mitochondrial COX1 gene; Ai1p 16322 AI1 854593 AI1 Saccharomyces cerevisiae Ai1p NP_009310.1 13818 D 4932 CDS NP_009311.2 6381999 854599 join(24156..24870,24906..25255) 1 NC_001224.1 Protein of unknown function, encoded within an intron of the mitochondrial COX1 gene; translational initiation codon is predicted to be ATA rather than ATG; Ai5_betap 25255 AI5_BETA 854599 AI5_BETA Saccharomyces cerevisiae Ai5_betap NP_009311.2 24156 D 4932 CDS NP_009312.1 6226526 854600 27666..27812 1 NC_001224.1 Subunit 8 of the F0 sector of mitochondrial inner membrane F1-F0 ATP synthase, encoded on the mitochondrial genome; Atp8p 27812 ATP8 854600 ATP8 Saccharomyces cerevisiae Atp8p NP_009312.1 27666 D 4932 CDS NP_009313.1 6226527 854601 28487..29266 1 NC_001224.1 Mitochondrially encoded subunit 6 of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; Atp6p 29266 ATP6 854601 ATP6 Saccharomyces cerevisiae Atp6p NP_009313.1 28487 D 4932 CDS NP_009315.1 6226529 854583 join(36540..36954,37723..37736,39141..39217,40841..41090,42508..42558,43297..43647) 1 NC_001224.1 Cytochrome b, mitochondrially encoded subunit of the ubiquinol-cytochrome c reductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p; Cobp 43647 COB 854583 COB Saccharomyces cerevisiae Cobp NP_009315.1 36540 D 4932 CDS NP_009316.1 6226532 854582 join(36540..36954,37723..37736,39141..39217,40841..42251) 1 NC_001224.1 Mitochondrial mRNA maturase, forms a complex with Nam2p to mediate splicing of the bI4 intron of the COB gene; encoded by both exon and intron sequences of partially processed COB mRNA; Bi4p 42251 BI4 854582 BI4 Saccharomyces cerevisiae Bi4p NP_009316.1 36540 D 4932 CDS NP_009317.1 6226531 854605 join(36540..36954,37723..37736,39141..40265) 1 NC_001224.1 Mitochondrial mRNA maturase, forms a complex with Mrs1p to mediate splicing of the bI3 intron of the COB gene; encoded by both exon and intron sequences of partially processed COB mRNA; Bi3p 40265 BI3 854605 BI3 Saccharomyces cerevisiae Bi3p NP_009317.1 36540 D 4932 CDS NP_009318.1 6226530 854604 join(36540..36954,37723..38579) 1 NC_001224.1 Mitochondrial mRNA maturase with a role in splicing, encoded by both exon and intron sequences of partially processed COB mRNA; Bi2p 38579 BI2 854604 BI2 Saccharomyces cerevisiae Bi2p NP_009318.1 36540 D 4932 CDS NP_009319.1 6226533 854584 46723..46953 1 NC_001224.1 Oli1p; F0-ATP synthase subunit 9 (ATPase-associated proteolipid), encoded on the mitochondrial genome; mutation confers oligomycin resistance; expression is specifically dependent on the nuclear genes AEP1 and AEP2 46953 OLI1 854584 OLI1 Saccharomyces cerevisiae F0-ATP synthase subunit 9 (ATPase-associated proteolipid), encoded on the mitochondrial genome; mutation confers oligomycin resistance; expression is specifically dependent on the nuclear genes AEP1 and AEP2 NP_009319.1 46723 D 4932 CDS NP_009320.1 6226534 854586 48901..50097 1 NC_001224.1 Var1p; Mitochondrial ribosomal protein of the small subunit, mitochondrially-encoded; polymorphic in different strains due to variation in number of AAT (asparagine) codons; translated near the mitochondrial inner membrane 50097 VAR1 854586 VAR1 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the small subunit, mitochondrially-encoded; polymorphic in different strains due to variation in number of AAT (asparagine) codons; translated near the mitochondrial inner membrane NP_009320.1 48901 D 4932 CDS NP_009324.1 6226538 854590 61022..61729 1 NC_001224.1 Sceip; I-SceI DNA endonuclease, encoded by the mitochondrial group I intron of the 21S_rRNA gene; mediates gene conversion that propagates the intron into intron-less copies of the 21S_rRNA gene 61729 SCEI 854590 SCEI Saccharomyces cerevisiae I-SceI DNA endonuclease, encoded by the mitochondrial group I intron of the 21S_rRNA gene; mediates gene conversion that propagates the intron into intron-less copies of the 21S_rRNA gene NP_009324.1 61022 D 4932 CDS NP_009326.1 6226540 854622 73758..74513 1 NC_001224.1 Subunit II of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits; Cox2p 74513 COX2 854622 COX2 Saccharomyces cerevisiae Cox2p NP_009326.1 73758 D 4932 CDS NP_009327.1 6226541 854623 join(74495..75622,75663..75872,75904..75984) 1 NC_001224.1 Q0255p; Maturase-like protein 75984 854623 Q0255 Saccharomyces cerevisiae Maturase-like protein NP_009327.1 74495 D 4932 CDS NP_009328.1 6226542 854627 79213..80022 1 NC_001224.1 Subunit III of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits; Cox3p 80022 COX3 854627 COX3 Saccharomyces cerevisiae Cox3p NP_009328.1 79213 D 4932 CDS NP_010835.1 6320756 856630 complement(264..4097) 1 NC_001137.2 Yel077cp; Helicase-like protein encoded within the telomeric Y' element 4097 856630 YEL077C Saccharomyces cerevisiae Helicase-like protein encoded within the telomeric Y' element NP_010835.1 264 R 4932 CDS NP_010836.1 6320759 856632 complement(join(4185..4322,4602..5114)) 1 NC_001137.2 Yel076c-ap; Putative protein of unknown function 5114 856632 YEL076C-A Saccharomyces cerevisiae Putative protein of unknown function NP_010836.1 4185 R 4932 CDS NP_010837.1 6320758 856633 complement(4464..5114) 1 NC_001137.2 Yel076cp; Putative protein of unknown function 5114 856633 YEL076C Saccharomyces cerevisiae Putative protein of unknown function NP_010837.1 4464 R 4932 CDS NP_010839.1 6320760 856634 complement(5345..5713) 1 NC_001137.2 Yel075cp; Putative protein of unknown function 5713 856634 YEL075C Saccharomyces cerevisiae Putative protein of unknown function NP_010839.1 5345 R 4932 CDS NP_010841.1 6320762 856636 complement(7230..7553) 1 NC_001137.2 Yel073cp; Putative protein of unknown function; located adjacent to ARS503 and the telomere on the left arm of chromosome V; regulated by inositol/choline 7553 856636 YEL073C Saccharomyces cerevisiae Putative protein of unknown function; located adjacent to ARS503 and the telomere on the left arm of chromosome V; regulated by inositol/choline NP_010841.1 7230 R 4932 CDS NP_010842.1 6320763 856637 13720..14415 1 NC_001137.2 Rmd6p; Protein required for sporulation 14415 RMD6 856637 RMD6 Saccharomyces cerevisiae Protein required for sporulation NP_010842.1 13720 D 4932 CDS NP_010843.1 6320764 856638 16355..17845 1 NC_001137.2 Dld3p; D-lactate dehydrogenase, part of the retrograde regulon which consists of genes whose expression is stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source, located in the cytoplasm 17845 DLD3 856638 DLD3 Saccharomyces cerevisiae D-lactate dehydrogenase, part of the retrograde regulon which consists of genes whose expression is stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source, located in the cytoplasm NP_010843.1 16355 D 4932 CDS NP_010844.1 6320765 856639 19589..21097 1 NC_001137.2 Dsf1p; Deletion suppressor of mpt5 mutation 21097 DSF1 856639 DSF1 Saccharomyces cerevisiae Deletion suppressor of mpt5 mutation NP_010844.1 19589 D 4932 CDS NP_010845.1 6320766 856640 complement(21537..23231) 1 NC_001137.2 Hxt13p; Hexose transporter, induced in the presence of non-fermentable carbon sources, induced by low levels of glucose, repressed by high levels of glucose 23231 HXT13 856640 HXT13 Saccharomyces cerevisiae Hexose transporter, induced in the presence of non-fermentable carbon sources, induced by low levels of glucose, repressed by high levels of glucose NP_010845.1 21537 R 4932 CDS NP_010847.1 6320769 856643 complement(26189..26776) 1 NC_001137.2 Yel067cp; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 26776 856643 YEL067C Saccharomyces cerevisiae Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_010847.1 26189 R 4932 CDS NP_010848.1 6320768 856642 26667..27206 1 NC_001137.2 Hpa3p; D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro 27206 HPA3 856642 HPA3 Saccharomyces cerevisiae D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro NP_010848.1 26667 D 4932 CDS NP_010849.1 6320770 856644 27657..29543 1 NC_001137.2 Sit1p; Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p 29543 SIT1 856644 SIT1 Saccharomyces cerevisiae Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p NP_010849.1 27657 D 4932 CDS NP_010850.1 6320771 856645 complement(29797..31239) 1 NC_001137.2 Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; Avt2p 31239 AVT2 856645 AVT2 Saccharomyces cerevisiae Avt2p NP_010850.1 29797 R 4932 CDS NP_010851.1 6320772 856646 complement(31694..33466) 1 NC_001137.2 Plasma membrane arginine permease, requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; Can1p 33466 CAN1 856646 CAN1 Saccharomyces cerevisiae Can1p NP_010851.1 31694 R 4932 CDS NP_010852.2 37362640 856647 34407..36254 1 NC_001137.2 Protein with a possible role in regulating expression of nitrogen permeases; transcription is induced in response to proline and urea; contains two PEST sequences; null mutant is resistant to cisplatin and doxorubicin; Npr2p 36254 NPR2 856647 NPR2 Saccharomyces cerevisiae Npr2p NP_010852.2 34407 D 4932 CDS NP_010853.2 37362641 856648 complement(36535..39537) 1 NC_001137.2 Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation; Cin8p 39537 CIN8 856648 CIN8 Saccharomyces cerevisiae Cin8p NP_010853.2 36535 R 4932 CDS NP_010854.1 6320775 856649 complement(40046..41953) 1 NC_001137.2 Vacuolar proteinase B (yscB), a serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; Prb1p 41953 PRB1 856649 PRB1 Saccharomyces cerevisiae Prb1p NP_010854.1 40046 R 4932 CDS NP_058154.1 7839166 856650 complement(42400..42624) 1 NC_001137.2 Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; Som1p 42624 SOM1 856650 SOM1 Saccharomyces cerevisiae Som1p NP_058154.1 42400 R 4932 CDS NP_010856.1 6320777 856652 43252..44925 1 NC_001137.2 Pcm1p; Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors 44925 PCM1 856652 PCM1 Saccharomyces cerevisiae Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors NP_010856.1 43252 D 4932 CDS NP_010857.1 6320778 856653 complement(45020..45721) 1 NC_001137.2 Yel057cp; Protein of unknown function involved in telomere maintenance; target of UME6 regulation 45721 856653 YEL057C Saccharomyces cerevisiae Protein of unknown function involved in telomere maintenance; target of UME6 regulation NP_010857.1 45020 R 4932 CDS NP_010858.1 6320779 856654 47168..48373 1 NC_001137.2 Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing; Hat2p 48373 HAT2 856654 HAT2 Saccharomyces cerevisiae Hat2p NP_010858.1 47168 D 4932 CDS NP_010859.1 6320780 856655 complement(48471..51539) 1 NC_001137.2 Pol5p; DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA 51539 POL5 856655 POL5 Saccharomyces cerevisiae DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA NP_010859.1 48471 R 4932 CDS NP_010860.1 6320781 856656 complement(52721..53218) 1 NC_001137.2 Rpl12ap; Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Bp; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins 53218 RPL12A 856656 RPL12A Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Bp; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins NP_010860.1 52721 R 4932 CDS NP_010861.1 6320782 856657 complement(53901..56102) 1 NC_001137.2 Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible; Mak10p 56102 MAK10 856657 MAK10 Saccharomyces cerevisiae Mak10p NP_010861.1 53901 R 4932 CDS NP_010862.1 6320783 856658 56571..58100 1 NC_001137.2 Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain; Afg1p 58100 AFG1 856658 AFG1 Saccharomyces cerevisiae Afg1p NP_010862.1 56571 D 4932 CDS NP_010863.1 6320784 856659 58378..59148 1 NC_001137.2 Vma8p; Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis 59148 VMA8 856659 VMA8 Saccharomyces cerevisiae Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis NP_010863.1 58378 D 4932 CDS NP_010864.1 6320785 856660 complement(59670..60851) 1 NC_001137.2 Rml2p; Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor 60851 RML2 856660 RML2 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor NP_010864.1 59670 R 4932 CDS NP_010865.1 6320786 856662 63728..64090 1 NC_001137.2 Pau2p; Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme 64090 PAU2 856662 PAU2 Saccharomyces cerevisiae Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme NP_010865.1 63728 D 4932 CDS NP_010866.1 6320787 856663 complement(64709..65167) 1 NC_001137.2 Yel048cp; Putative protein of unknown function; synthetic lethal with gcs1delta 65167 856663 YEL048C Saccharomyces cerevisiae Putative protein of unknown function; synthetic lethal with gcs1delta NP_010866.1 64709 R 4932 CDS NP_010867.1 6320788 856664 complement(65385..66797) 1 NC_001137.2 Yel047cp; Soluble fumarate reductase, required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies 66797 856664 YEL047C Saccharomyces cerevisiae Soluble fumarate reductase, required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies NP_010867.1 65385 R 4932 CDS NP_010868.1 6320789 856665 complement(67629..68792) 1 NC_001137.2 Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis; Gly1p 68792 GLY1 856665 GLY1 Saccharomyces cerevisiae Gly1p NP_010868.1 67629 R 4932 CDS NP_010870.1 6320791 856667 69757..70257 1 NC_001137.2 Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; Ies6p 70257 IES6 856667 IES6 Saccharomyces cerevisiae Ies6p NP_010870.1 69757 D 4932 CDS NP_010871.1 6320792 856668 70478..73348 1 NC_001137.2 Yel043wp; Predicted cytoskeleton protein involved in intracellular signalling based on quantitative analysis of protein-protein interaction maps; may interact with ribosomes, based on co-purification studies; contains fibronectin type III domain fold 73348 856668 YEL043W Saccharomyces cerevisiae Predicted cytoskeleton protein involved in intracellular signalling based on quantitative analysis of protein-protein interaction maps; may interact with ribosomes, based on co-purification studies; contains fibronectin type III domain fold NP_010871.1 70478 D 4932 CDS NP_010872.1 6320793 856669 73771..75327 1 NC_001137.2 Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate; Gda1p 75327 GDA1 856669 GDA1 Saccharomyces cerevisiae Gda1p NP_010872.1 73771 D 4932 CDS NP_010873.1 6320794 856670 75944..77431 1 NC_001137.2 Yef1p; ATP-NADH kinase; phosophorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; sequence similarity to Utr1p and Pos5p; overexpression complements certain pos5 phenotypes 77431 YEF1 856670 YEF1 Saccharomyces cerevisiae ATP-NADH kinase; phosophorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; sequence similarity to Utr1p and Pos5p; overexpression complements certain pos5 phenotypes NP_010873.1 75944 D 4932 CDS NP_010874.1 6320795 856671 78053..79456 1 NC_001137.2 Utr2p; Cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; putative chitin transglycosidase; glycosylphosphatidylinositol (GPI)-anchored protein localized to the bud neck; has a role in cell wall maintenance 79456 UTR2 856671 UTR2 Saccharomyces cerevisiae Cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; putative chitin transglycosidase; glycosylphosphatidylinositol (GPI)-anchored protein localized to the bud neck; has a role in cell wall maintenance NP_010874.1 78053 D 4932 CDS NP_010875.1 6320796 856672 complement(79636..79977) 1 NC_001137.2 Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; Cyc7p 79977 CYC7 856672 CYC7 Saccharomyces cerevisiae Cyc7p NP_010875.1 79636 R 4932 CDS NP_010876.2 99030924 856673 80462..81145 1 NC_001137.2 Utr4p; Protein of unknown function with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, found in both the cytoplasm and nucleus 81145 UTR4 856673 UTR4 Saccharomyces cerevisiae Protein of unknown function with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, found in both the cytoplasm and nucleus NP_010876.2 80462 D 4932 CDS NP_010877.1 6320798 856674 complement(81407..82603) 1 NC_001137.2 Rad23p; Protein with ubiquitin-like N terminus, recognizes and binds damaged DNA (with Rad4p) during nucleotide excision repair; regulates Rad4p levels, subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human HR23A and HR23B proteins 82603 RAD23 856674 RAD23 Saccharomyces cerevisiae Protein with ubiquitin-like N terminus, recognizes and binds damaged DNA (with Rad4p) during nucleotide excision repair; regulates Rad4p levels, subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human HR23A and HR23B proteins NP_010877.1 81407 R 4932 CDS NP_010878.1 6320799 856675 complement(83050..84552) 1 NC_001137.2 Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol; Anp1p 84552 ANP1 856675 ANP1 Saccharomyces cerevisiae Anp1p NP_010878.1 83050 R 4932 CDS NP_010879.1 6320800 856676 complement(85045..85545) 1 NC_001137.2 Utr5p; Protein of unknown function; transcription may be regulated by Gcr1p 85545 UTR5 856676 UTR5 Saccharomyces cerevisiae Protein of unknown function; transcription may be regulated by Gcr1p NP_010879.1 85045 R 4932 CDS NP_010880.1 6320801 856677 85676..86149 1 NC_001137.2 Translation initiation factor eIF-5A, promotes formation of the first peptide bond; similar to and functionally redundant with Anb1p; possible role in translation elongation; undergoes an essential hypusination modification; Hyp2p 86149 HYP2 856677 HYP2 Saccharomyces cerevisiae Hyp2p NP_010880.1 85676 D 4932 CDS NP_010882.1 6320803 856680 86937..89852 1 NC_001137.2 Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; Mcm3p 89852 MCM3 856680 MCM3 Saccharomyces cerevisiae Mcm3p NP_010882.1 86937 D 4932 CDS NP_010883.1 6320804 856681 90258..93905 1 NC_001137.2 Spf1p; P-type ATPase, ion transporter of the ER membrane involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1 93905 SPF1 856681 SPF1 Saccharomyces cerevisiae P-type ATPase, ion transporter of the ER membrane involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1 NP_010883.1 90258 D 4932 CDS NP_010884.1 6320805 856682 94644..96578 1 NC_001137.2 Heat shock protein of the Hsp70 family, localized in mitochondrial nucleoids, plays a role in protein translocation, interacts with Mge1p in an ATP-dependent manner; overexpression induces extensive mitochondrial DNA aggregations; Ecm10p 96578 ECM10 856682 ECM10 Saccharomyces cerevisiae Ecm10p NP_010884.1 94644 D 4932 CDS NP_010885.1 6320806 856683 complement(96858..97796) 1 NC_001137.2 Putative pyridoxal kinase, key enzyme in vitamin B6 metabolism; involved in maintaining levels of pyridoxal 5'-phosphate, the active form of vitamin B6; required for genome integrity; homolog of E. coli PdxK; involved in bud-site selection; Bud16p 97796 BUD16 856683 BUD16 Saccharomyces cerevisiae Bud16p NP_010885.1 96858 R 4932 CDS NP_010887.1 6320808 856686 100769..101251 1 NC_001137.2 Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis; Cup5p 101251 CUP5 856686 CUP5 Saccharomyces cerevisiae Cup5p NP_010887.1 100769 D 4932 CDS NP_010888.1 6320809 856687 101943..102323 1 NC_001137.2 Snu13p; RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein 102323 SNU13 856687 SNU13 Saccharomyces cerevisiae RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein NP_010888.1 101943 D 4932 CDS NP_010889.1 6320810 856688 complement(102581..106147) 1 NC_001137.2 Yel025cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus 106147 856688 YEL025C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus NP_010889.1 102581 R 4932 CDS NP_010890.1 6320811 856689 107260..107907 1 NC_001137.2 Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration; Rip1p 107907 RIP1 856689 RIP1 Saccharomyces cerevisiae Rip1p NP_010890.1 107260 D 4932 CDS NP_010891.1 6320812 856690 complement(108504..110552) 1 NC_001137.2 Yel023cp; Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene 110552 856690 YEL023C Saccharomyces cerevisiae Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene NP_010891.1 108504 R 4932 CDS NP_010892.1 6320813 856691 111421..115800 1 NC_001137.2 Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs), involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; similar to but not functionally redundant with Gea1p; Gea2p 115800 GEA2 856691 GEA2 Saccharomyces cerevisiae Gea2p NP_010892.1 111421 D 4932 CDS NP_010893.1 6320814 856692 116167..116970 1 NC_001137.2 Ura3p; Orotidine-5'-phosphate (OMP) decarboxylase, catalyzes the sixth enzymatic step in the de novo biosynthesis of pyrimidines, converting OMP into uridine monophosphate (UMP); converts 5-FOA into 5-fluorouracil, a toxic compound 116970 URA3 856692 URA3 Saccharomyces cerevisiae Orotidine-5'-phosphate (OMP) decarboxylase, catalyzes the sixth enzymatic step in the de novo biosynthesis of pyrimidines, converting OMP into uridine monophosphate (UMP); converts 5-FOA into 5-fluorouracil, a toxic compound NP_010893.1 116167 D 4932 CDS NP_010894.1 6320815 856693 117211..117474 1 NC_001137.2 Tim9p; Mitochondrial intermembrane space protein, forms a complex with Mrs11p/Tim10p that mediates import and insertion of a subset of polytopic inner membrane proteins; may prevent aggregation of incoming proteins in a chaperone-like manner 117474 TIM9 856693 TIM9 Saccharomyces cerevisiae Mitochondrial intermembrane space protein, forms a complex with Mrs11p/Tim10p that mediates import and insertion of a subset of polytopic inner membrane proteins; may prevent aggregation of incoming proteins in a chaperone-like manner NP_010894.1 117211 D 4932 CDS NP_010895.1 6320816 856694 complement(118617..120299) 1 NC_001137.2 hypothetical protein with low sequence identity to Pdc1p; Yel020cp 120299 856694 YEL020C Saccharomyces cerevisiae Yel020cp NP_010895.1 118617 R 4932 CDS NP_010896.1 6320817 856695 complement(120498..121301) 1 NC_001137.2 SUMO ligase involved in chromosomal organization and DNA repair; essential subunit of the Mms21-Smc5-Smc6 complex; mutants are sensitive to methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination; Mms21p 121301 MMS21 856695 MMS21 Saccharomyces cerevisiae Mms21p NP_010896.1 120498 R 4932 CDS NP_010897.1 6320818 856696 121471..122310 1 NC_001137.2 Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex; Eaf5p 122310 EAF5 856696 EAF5 Saccharomyces cerevisiae Eaf5p NP_010897.1 121471 D 4932 CDS NP_010898.1 6320819 856697 complement(122798..122929) 1 NC_001137.2 Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; nearly identical to PMP1; Pmp2p 122929 PMP2 856697 PMP2 Saccharomyces cerevisiae Pmp2p NP_010898.1 122798 R 4932 CDS NP_010899.1 6320820 856698 123657..124670 1 NC_001137.2 Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery; Gtt3p 124670 GTT3 856698 GTT3 Saccharomyces cerevisiae Gtt3p NP_010899.1 123657 D 4932 CDS NP_010900.1 6320821 856699 complement(124737..126218) 1 NC_001137.2 Nucleotide pyrophosphatase/phosphodiesterase family member; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; Npp2p 126218 NPP2 856699 NPP2 Saccharomyces cerevisiae Npp2p NP_010900.1 124737 R 4932 CDS NP_010901.1 6320822 856700 126629..128284 1 NC_001137.2 Non-essential conserved protein of unknown function, plays a role in mRNA decapping by specifically affecting the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies; Edc3p 128284 EDC3 856700 EDC3 Saccharomyces cerevisiae Edc3p NP_010901.1 126629 D 4932 CDS NP_010903.1 6320824 856702 128825..130561 1 NC_001137.2 Vac8p; Phosphorylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions 130561 VAC8 856702 VAC8 Saccharomyces cerevisiae Phosphorylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions NP_010903.1 128825 D 4932 CDS NP_010904.2 6579192 856704 join(131772..131776,131900..132551) 1 NC_001137.2 Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro; Ubc8p 132551 UBC8 856704 UBC8 Saccharomyces cerevisiae Ubc8p NP_010904.2 131772 D 4932 CDS NP_010905.1 6320826 856705 133120..135234 1 NC_001137.2 Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; Glc3p 135234 GLC3 856705 GLC3 Saccharomyces cerevisiae Glc3p NP_010905.1 133120 D 4932 CDS NP_010907.1 6320828 856709 complement(138918..139763) 1 NC_001137.2 Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels; Gcn4p 139763 GCN4 856709 GCN4 Saccharomyces cerevisiae Gcn4p NP_010907.1 138918 R 4932 CDS NP_010909.1 6320830 856711 141891..143891 1 NC_001137.2 Yel007wp; Putative protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) 143891 856711 YEL007W Saccharomyces cerevisiae Putative protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) NP_010909.1 141891 D 4932 CDS NP_010910.1 6320831 856712 144326..145333 1 NC_001137.2 Yea6p; Putative mitochondrial NAD+ transporter, member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog 145333 YEA6 856712 YEA6 Saccharomyces cerevisiae Putative mitochondrial NAD+ transporter, member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog NP_010910.1 144326 D 4932 CDS NP_010911.1 6320832 856713 complement(145906..146754) 1 NC_001137.2 Vab2p; Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 146754 VAB2 856713 VAB2 Saccharomyces cerevisiae Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern NP_010911.1 145906 R 4932 CDS NP_010912.1 6320833 856714 146950..147978 1 NC_001137.2 Yea4p; Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER 147978 YEA4 856714 YEA4 Saccharomyces cerevisiae Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER NP_010912.1 146950 D 4932 CDS NP_010913.2 154199604 856715 join(148175..148193,148282..148598) 1 NC_001137.2 Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it; Gim4p 148598 GIM4 856715 GIM4 Saccharomyces cerevisiae Gim4p NP_010913.2 148175 D 4932 CDS NP_010914.1 6320835 856716 complement(148721..150013) 1 NC_001137.2 Wbp1p; Beta subunit of the oligosaccharyl transferase (OST) glycoprotein complex; required for N-linked glycosylation of proteins in the endoplasmic reticulum 150013 WBP1 856716 WBP1 Saccharomyces cerevisiae Beta subunit of the oligosaccharyl transferase (OST) glycoprotein complex; required for N-linked glycosylation of proteins in the endoplasmic reticulum NP_010914.1 148721 R 4932 CDS NP_010915.1 6320836 856717 complement(150300..150977) 1 NC_001137.2 Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52 foci; Irc22p 150977 IRC22 856717 IRC22 Saccharomyces cerevisiae Irc22p NP_010915.1 150300 R 4932 CDS NP_010916.1 6320837 856718 153519..155807 1 NC_001137.2 Mnn1p; Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family 155807 MNN1 856718 MNN1 Saccharomyces cerevisiae Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family NP_010916.1 153519 D 4932 CDS NP_010917.1 6320838 856719 156802..157497 1 NC_001137.2 Nop16p; Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis 157497 NOP16 856719 NOP16 Saccharomyces cerevisiae Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis NP_010917.1 156802 D 4932 CDS NP_010918.1 6320839 856720 complement(join(157735..158993,159087..159117)) 1 NC_001137.2 Pmi40p; Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation 159117 PMI40 856720 PMI40 Saccharomyces cerevisiae Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation NP_010918.1 157735 R 4932 CDS NP_010919.1 6320840 856721 159579..160274 1 NC_001137.2 Protein of unknown function, localized to the mitochondrial outer membrane; Fmp52p 160274 FMP52 856721 FMP52 Saccharomyces cerevisiae Fmp52p NP_010919.1 159579 D 4932 CDS NP_010920.1 6320841 856722 160549..162441 1 NC_001137.2 Ynd1p; Apyrase with wide substrate specificity, involved in preventing the inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates which are inhibitors of glycotransferases; partially redundant with Gda1p 162441 YND1 856722 YND1 Saccharomyces cerevisiae Apyrase with wide substrate specificity, involved in preventing the inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates which are inhibitors of glycotransferases; partially redundant with Gda1p NP_010920.1 160549 D 4932 CDS NP_010921.1 6320842 856723 162722..164284 1 NC_001137.2 Nug1p; GTPase that associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits from the nucleus 164284 NUG1 856723 NUG1 Saccharomyces cerevisiae GTPase that associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits from the nucleus NP_010921.1 162722 D 4932 CDS NP_010922.1 6320843 856724 164526..166082 1 NC_001137.2 Pac2p; Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl 166082 PAC2 856724 PAC2 Saccharomyces cerevisiae Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl NP_010922.1 164526 D 4932 CDS NP_010923.1 6320844 856725 complement(join(166236..166770,166874..166884)) 1 NC_001137.2 Tma20p; Protein of unknown function that associates with ribosomes and has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1 166884 TMA20 856725 TMA20 Saccharomyces cerevisiae Protein of unknown function that associates with ribosomes and has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1 NP_010923.1 166236 R 4932 CDS NP_010924.1 6320845 856726 complement(167807..171817) 1 NC_001137.2 Sec3p; Non-essential subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, Exo84p) which mediates targeting of post-Golgi vesicles to sites of active exocytosis; Sec3p specifically is a spatial landmark for secretion 171817 SEC3 856726 SEC3 Saccharomyces cerevisiae Non-essential subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, Exo84p) which mediates targeting of post-Golgi vesicles to sites of active exocytosis; Sec3p specifically is a spatial landmark for secretion NP_010924.1 167807 R 4932 CDS NP_010925.1 6320846 856727 172114..172491 1 NC_001137.2 Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport; Ntf2p 172491 NTF2 856727 NTF2 Saccharomyces cerevisiae Ntf2p NP_010925.1 172114 D 4932 CDS NP_010926.1 6320847 856728 complement(172633..173337) 1 NC_001137.2 Yer010cp; Protein of unknown function, forms a ring-shaped homotrimer; has similarity to members of the prokaryotic rraA family; possibly involved in a phosphotransfer reaction 173337 856728 YER010C Saccharomyces cerevisiae Protein of unknown function, forms a ring-shaped homotrimer; has similarity to members of the prokaryotic rraA family; possibly involved in a phosphotransfer reaction NP_010926.1 172633 R 4932 CDS NP_010927.1 6320848 856729 175247..176011 1 NC_001137.2 Tir1p; Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking 176011 TIR1 856729 TIR1 Saccharomyces cerevisiae Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking NP_010927.1 175247 D 4932 CDS NP_010928.1 6320849 856731 177834..178430 1 NC_001137.2 Pre1p; 20S proteasome beta-type subunit; localizes to the nucleus throughout the cell cycle 178430 PRE1 856731 PRE1 Saccharomyces cerevisiae 20S proteasome beta-type subunit; localizes to the nucleus throughout the cell cycle NP_010928.1 177834 D 4932 CDS NP_010929.1 6320850 856732 178840..182277 1 NC_001137.2 Prp22p; DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes 182277 PRP22 856732 PRP22 Saccharomyces cerevisiae DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes NP_010929.1 178840 D 4932 CDS NP_010930.1 6320851 856733 182599..184218 1 NC_001137.2 Protoporphyrinogen oxidase, a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX; Hem14p 184218 HEM14 856733 HEM14 Saccharomyces cerevisiae Hem14p NP_010930.1 182599 D 4932 CDS NP_076437.1 13112038 856735 complement(join(183730..184168,184677..184699)) 1 NC_001137.2 Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; Bud25p 184699 BUD25 856735 BUD25 Saccharomyces cerevisiae Bud25p NP_076437.1 183730 R 4932 CDS NP_010931.1 6320852 856734 184540..186774 1 NC_001137.2 Long chain fatty acyl-CoA synthetase; accepts a wider range of acyl chain lengths than Faa1p, preferring C9:0-C13:0; involved in the activation of endogenous pools of fatty acids; Faa2p 186774 FAA2 856734 FAA2 Saccharomyces cerevisiae Faa2p NP_010931.1 184540 D 4932 CDS NP_010932.1 6320853 856736 188276..189310 1 NC_001137.2 Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally; Bim1p 189310 BIM1 856736 BIM1 Saccharomyces cerevisiae Bim1p NP_010932.1 188276 D 4932 CDS NP_010933.1 6320854 856737 complement(189502..191787) 1 NC_001137.2 Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes; Afg3p 191787 AFG3 856737 AFG3 Saccharomyces cerevisiae Afg3p NP_010933.1 189502 R 4932 CDS NP_010934.1 6320855 856738 complement(191958..192623) 1 NC_001137.2 Spc25p; Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering 192623 SPC25 856738 SPC25 Saccharomyces cerevisiae Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering NP_010934.1 191958 R 4932 CDS NP_010935.1 6320856 856739 192796..194229 1 NC_001137.2 Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance; Isc1p 194229 ISC1 856739 ISC1 Saccharomyces cerevisiae Isc1p NP_010935.1 192796 D 4932 CDS NP_010936.1 6320857 856740 complement(194272..194538) 1 NC_001137.2 Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p; Sbh2p 194538 SBH2 856740 SBH2 Saccharomyces cerevisiae Sbh2p NP_010936.1 194272 R 4932 CDS NP_010937.1 6320858 856741 195167..196516 1 NC_001137.2 Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; Gpa2p 196516 GPA2 856741 GPA2 Saccharomyces cerevisiae Gpa2p NP_010937.1 195167 D 4932 CDS NP_010938.1 6320859 856742 196947..198518 1 NC_001137.2 Rpn3p; Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control 198518 RPN3 856742 RPN3 Saccharomyces cerevisiae Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control NP_010938.1 196947 D 4932 CDS NP_010939.1 6320860 856743 198811..200874 1 NC_001137.2 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; Srb4p 200874 SRB4 856743 SRB4 Saccharomyces cerevisiae Srb4p NP_010939.1 198811 D 4932 CDS NP_010940.1 6320861 856744 201075..201935 1 NC_001137.2 Pro3p; Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis 201935 PRO3 856744 PRO3 Saccharomyces cerevisiae Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis NP_010940.1 201075 D 4932 CDS NP_010941.1 6320862 856745 202191..204962 1 NC_001137.2 Yat2p; Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane 204962 YAT2 856745 YAT2 Saccharomyces cerevisiae Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane NP_010941.1 202191 D 4932 CDS NP_010942.1 6320863 856746 205250..206833 1 NC_001137.2 Gcd11p; Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met 206833 GCD11 856746 GCD11 Saccharomyces cerevisiae Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met NP_010942.1 205250 D 4932 CDS NP_010943.1 6320864 856748 complement(207643..208473) 1 NC_001137.2 Phosphatidylserine synthase, functions in phospholipid biosynthesis; catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine, transcriptionally repressed by myo-inositol and choline; Cho1p 208473 CHO1 856748 CHO1 Saccharomyces cerevisiae Cho1p NP_010943.1 207643 R 4932 CDS NP_010944.1 6320865 856749 complement(208978..210231) 1 NC_001137.2 One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain; Gal83p 210231 GAL83 856749 GAL83 Saccharomyces cerevisiae Gal83p NP_010944.1 208978 R 4932 CDS NP_010945.1 6320866 856750 complement(210691..211875) 1 NC_001137.2 Probable transcriptional repressor involved in response to toxic agents such as hydroxyurea that inhibit ribonucleotide reductase; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; Mig3p 211875 MIG3 856750 MIG3 Saccharomyces cerevisiae Mig3p NP_010945.1 210691 R 4932 CDS NP_010946.1 6320867 856751 complement(212586..213176) 1 NC_001137.2 Smb1p; Core Sm protein Sm B; part of heteroheptameric complex (with Smd1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm B and Sm B' 213176 SMB1 856751 SMB1 Saccharomyces cerevisiae Core Sm protein Sm B; part of heteroheptameric complex (with Smd1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm B and Sm B' NP_010946.1 212586 R 4932 CDS NP_010947.2 83578097 856752 213436..213897 1 NC_001137.2 Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; Chz1p 213897 CHZ1 856752 CHZ1 Saccharomyces cerevisiae Chz1p NP_010947.2 213436 D 4932 CDS NP_010948.1 6320869 856753 complement(214075..214746) 1 NC_001137.2 Ypt31p; GTPase of the Ypt/Rab family, very similar to Ypt32p; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi 214746 YPT31 856753 YPT31 Saccharomyces cerevisiae GTPase of the Ypt/Rab family, very similar to Ypt32p; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi NP_010948.1 214075 R 4932 CDS NP_010949.2 37362642 856754 215062..217692 1 NC_001137.2 Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate; Fir1p 217692 FIR1 856754 FIR1 Saccharomyces cerevisiae Fir1p NP_010949.2 215062 D 4932 CDS NP_010950.1 6320871 856755 complement(218056..221286) 1 NC_001137.2 Zrg8p; Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency 221286 ZRG8 856755 ZRG8 Saccharomyces cerevisiae Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency NP_010950.1 218056 R 4932 CDS NP_010951.1 6320872 856756 221845..222402 1 NC_001137.2 Yer034wp; Putative protein of unknown function; non-essential gene; expression induced upon calcium shortage 222402 856756 YER034W Saccharomyces cerevisiae Putative protein of unknown function; non-essential gene; expression induced upon calcium shortage NP_010951.1 221845 D 4932 CDS NP_010952.1 6320873 856757 222638..223075 1 NC_001137.2 RNA-binding protein, activates mRNA decapping directly by binding to the mRNA substrate and enhancing the activity of the decapping proteins Dcp1p and Dcp2p; Edc2p 223075 EDC2 856757 EDC2 Saccharomyces cerevisiae Edc2p NP_010952.1 222638 D 4932 CDS NP_010953.1 6320874 856758 complement(223366..225198) 1 NC_001137.2 Arb1p; ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p 225198 ARB1 856758 ARB1 Saccharomyces cerevisiae ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p NP_010953.1 223366 R 4932 CDS NP_010954.1 6320875 856759 225888..226853 1 NC_001137.2 Protein of unknown function, expression is induced by low phosphate levels and by inactivation of Pho85p; Phm8p 226853 PHM8 856759 PHM8 Saccharomyces cerevisiae Phm8p NP_010954.1 225888 D 4932 CDS NP_010955.1 6320876 856760 complement(226857..228251) 1 NC_001137.2 Kre29p; Essential subunit of the Mms21-Smc5-Smc6 complex; protein of unknown function; required for growth and DNA repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance 228251 KRE29 856760 KRE29 Saccharomyces cerevisiae Essential subunit of the Mms21-Smc5-Smc6 complex; protein of unknown function; required for growth and DNA repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance NP_010955.1 226857 R 4932 CDS NP_010956.1 6320877 856761 complement(228455..229204) 1 NC_001137.2 Protein of unknown function, has homology to Vrg4p; Hvg1p 229204 HVG1 856761 HVG1 Saccharomyces cerevisiae Hvg1p NP_010956.1 228455 R 4932 CDS NP_010957.1 6320878 856762 complement(229262..229480) 1 NC_001137.2 Yer039c-ap; Putative protein of unknown function; YER039C-A is not an essential gene 229480 856762 YER039C-A Saccharomyces cerevisiae Putative protein of unknown function; YER039C-A is not an essential gene NP_010957.1 229262 R 4932 CDS NP_010958.1 6320879 856763 229794..231986 1 NC_001137.2 Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source; Gln3p 231986 GLN3 856763 GLN3 Saccharomyces cerevisiae Gln3p NP_010958.1 229794 D 4932 CDS NP_010959.1 6320880 856764 232460..234739 1 NC_001137.2 Yen1p; Protein of unknown function, has similarity to endonuclease Rth1p; potentially phosphorylated by Cdc28p 234739 YEN1 856764 YEN1 Saccharomyces cerevisiae Protein of unknown function, has similarity to endonuclease Rth1p; potentially phosphorylated by Cdc28p NP_010959.1 232460 D 4932 CDS NP_010960.1 6320881 856765 234936..235490 1 NC_001137.2 Peptide methionine sulfoxide reductase, reverses the oxidation of methionine residues; involved in oxidative damage repair, providing resistance to oxidative stress and regulation of lifespan; Mxr1p 235490 MXR1 856765 MXR1 Saccharomyces cerevisiae Mxr1p NP_010960.1 234936 D 4932 CDS NP_010961.1 6320882 856766 complement(235769..237118) 1 NC_001137.2 Sah1p; S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor 237118 SAH1 856766 SAH1 Saccharomyces cerevisiae S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor NP_010961.1 235769 R 4932 CDS NP_010962.1 6320883 856767 complement(237569..238015) 1 NC_001137.2 Erg28p; Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p 238015 ERG28 856767 ERG28 Saccharomyces cerevisiae Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p NP_010962.1 237569 R 4932 CDS NP_010963.1 6320884 856768 complement(join(238459..239622,239711..239773)) 1 NC_001137.2 Meiosis-specific protein involved in recombination; required for chromosome synapsis; required for production of viable spores; Mei4p 239773 MEI4 856768 MEI4 Saccharomyces cerevisiae Mei4p NP_010963.1 238459 R 4932 CDS NP_010964.1 6320885 856769 complement(240031..241500) 1 NC_001137.2 Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, may regulate transcription of genes involved in utilization of non-optimal carbon sources; Aca1p 241500 ACA1 856769 ACA1 Saccharomyces cerevisiae Aca1p NP_010964.1 240031 R 4932 CDS NP_010965.1 6320886 856770 243179..243610 1 NC_001137.2 Spo73p; Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis 243610 SPO73 856770 SPO73 Saccharomyces cerevisiae Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis NP_010965.1 243179 D 4932 CDS NP_010966.1 6320887 856771 complement(243809..246502) 1 NC_001137.2 Sap1p; Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system 246502 SAP1 856771 SAP1 Saccharomyces cerevisiae Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system NP_010966.1 243809 R 4932 CDS NP_010967.1 6320888 856772 complement(246981..248156) 1 NC_001137.2 Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly; Caj1p 248156 CAJ1 856772 CAJ1 Saccharomyces cerevisiae Caj1p NP_010967.1 246981 R 4932 CDS NP_010968.1 6320889 856774 250717..251001 1 NC_001137.2 Protein required for mitochondrial iron-sulfur cluster biosynthesis; Isd11p 251001 ISD11 856774 ISD11 Saccharomyces cerevisiae Isd11p NP_010968.1 250717 D 4932 CDS NP_010969.1 6320890 856775 251727..253661 1 NC_001137.2 Tpa1p; Protein of unknown function; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; has a role in translation termination efficiency, mRNA poly(A) tail length and mRNA stability 253661 TPA1 856775 TPA1 Saccharomyces cerevisiae Protein of unknown function; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; has a role in translation termination efficiency, mRNA poly(A) tail length and mRNA stability NP_010969.1 251727 D 4932 CDS NP_010970.2 83578098 856776 complement(253970..254386) 1 NC_001137.2 Rsm18p; Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein 254386 RSM18 856776 RSM18 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein NP_010970.2 253970 R 4932 CDS NP_010971.1 6320892 856777 254655..256133 1 NC_001137.2 JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe; Jhd1p 256133 JHD1 856777 JHD1 Saccharomyces cerevisiae Jhd1p NP_010971.1 254655 D 4932 CDS NP_010972.1 6320893 856778 complement(256374..257957) 1 NC_001137.2 Hom3p; Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis 257957 HOM3 856778 HOM3 Saccharomyces cerevisiae Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis NP_010972.1 256374 R 4932 CDS NP_010973.1 6320894 856779 complement(258736..259638) 1 NC_001137.2 Pic2p; Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature 259638 PIC2 856779 PIC2 Saccharomyces cerevisiae Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature NP_010973.1 258736 R 4932 CDS NP_061492.1 9755330 856780 complement(260932..261045) 1 NC_001137.2 Yer053c-ap; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum 261045 856780 YER053C-A Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum NP_061492.1 260932 R 4932 CDS NP_010974.1 6320895 856781 complement(262051..263697) 1 NC_001137.2 Putative regulatory subunit of the protein phosphatase Glc7p, involved in glycogen metabolism; contains a conserved motif (GVNK motif) that is also found in Gac1p, Pig1p, and Pig2p; Gip2p 263697 GIP2 856781 GIP2 Saccharomyces cerevisiae Gip2p NP_010974.1 262051 R 4932 CDS NP_010975.1 6320896 856782 complement(264891..265784) 1 NC_001137.2 His1p; ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control 265784 HIS1 856782 HIS1 Saccharomyces cerevisiae ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control NP_010975.1 264891 R 4932 CDS NP_010976.1 6320897 856783 complement(266511..268112) 1 NC_001137.2 Purine-cytosine permease, mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation; Fcy2p 268112 FCY2 856783 FCY2 Saccharomyces cerevisiae Fcy2p NP_010976.1 266511 R 4932 CDS NP_010977.2 9755331 856784 complement(join(269421..269749,270147..270183)) 1 NC_001137.2 Rpl34ap; Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Bp and has similarity to rat L34 ribosomal protein 270183 RPL34A 856784 RPL34A Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Bp and has similarity to rat L34 ribosomal protein NP_010977.2 269421 R 4932 CDS NP_010978.1 6320899 856785 complement(270735..271124) 1 NC_001137.2 Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro; Hmf1p 271124 HMF1 856785 HMF1 Saccharomyces cerevisiae Hmf1p NP_010978.1 270735 R 4932 CDS NP_010979.1 6320900 856786 271766..272089 1 NC_001137.2 Protein required for assembly of cytochrome c oxidase; Pet117p 272089 PET117 856786 PET117 Saccharomyces cerevisiae Pet117p NP_010979.1 271766 D 4932 CDS NP_010980.1 6320901 856787 272622..273884 1 NC_001137.2 Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; involved in the control of glycogen storage by Pho85p; stabilized by Elongin C binding; Pcl6p 273884 PCL6 856787 PCL6 Saccharomyces cerevisiae Pcl6p NP_010980.1 272622 D 4932 CDS NP_010981.1 6320902 856788 274565..276151 1 NC_001137.2 Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function; Fcy21p 276151 FCY21 856788 FCY21 Saccharomyces cerevisiae Fcy21p NP_010981.1 274565 D 4932 CDS NP_010982.1 6320903 856789 276570..278162 1 NC_001137.2 Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function; Fcy22p 278162 FCY22 856789 FCY22 Saccharomyces cerevisiae Fcy22p NP_010982.1 276570 D 4932 CDS NP_010983.1 6320904 856790 complement(278296..279624) 1 NC_001137.2 Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration; Cem1p 279624 CEM1 856790 CEM1 Saccharomyces cerevisiae Cem1p NP_010983.1 278296 R 4932 CDS NP_010984.1 6320905 856791 complement(279928..280680) 1 NC_001137.2 One of two redundant DL-glycerol-3-phosphatases (RHR2/GPP1 encodes the other) involved in glycerol biosynthesis; induced in response to hyperosmotic stress and oxidative stress, and during the diauxic transition; Hor2p 280680 HOR2 856791 HOR2 Saccharomyces cerevisiae Hor2p NP_010984.1 279928 R 4932 CDS NP_010985.1 6320906 856792 281708..282364 1 NC_001137.2 Tho1p; Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation 282364 THO1 856792 THO1 Saccharomyces cerevisiae Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation NP_010985.1 281708 D 4932 CDS NP_010986.1 6320907 856793 complement(282703..284220) 1 NC_001137.2 Yer064cp; Non-essential nuclear protein; null mutation has global effects on transcription 284220 856793 YER064C Saccharomyces cerevisiae Non-essential nuclear protein; null mutation has global effects on transcription NP_010986.1 282703 R 4932 CDS NP_010987.1 6320908 856794 complement(285239..286912) 1 NC_001137.2 Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose; Icl1p 286912 ICL1 856794 ICL1 Saccharomyces cerevisiae Icl1p NP_010987.1 285239 R 4932 CDS NP_010988.1 6320909 856796 290240..290797 1 NC_001137.2 Yer066wp; Putative protein of unknown function; YER066W is not an essential gene 290797 856796 YER066W Saccharomyces cerevisiae Putative protein of unknown function; YER066W is not an essential gene NP_010988.1 290240 D 4932 CDS NP_010990.1 6320910 856797 292064..292549 1 NC_001137.2 Yer067wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YER067W is not an essential gene 292549 856797 YER067W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YER067W is not an essential gene NP_010990.1 292064 D 4932 CDS NP_010991.1 6320912 856799 293048..294811 1 NC_001137.2 Mot2p; Component of the CCR4-NOT complex, which has multiple roles in transcription regulation, mRNA degradation, and post-transcriptional modifications; with Ubc4p, ubiquitylates subunits of the nascent polypeptide-associated complex (NAC) 294811 MOT2 856799 MOT2 Saccharomyces cerevisiae Component of the CCR4-NOT complex, which has multiple roles in transcription regulation, mRNA degradation, and post-transcriptional modifications; with Ubc4p, ubiquitylates subunits of the nascent polypeptide-associated complex (NAC) NP_010991.1 293048 D 4932 CDS NP_010992.1 6320913 856800 295408..297999 1 NC_001137.2 Protein that is processed in the mitochondrion to yield acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase, which catalyze the 2nd and 3rd steps in arginine biosynthesis; enzymes form a complex with Arg2p; Arg5,6p 297999 ARG5,6 856800 ARG5,6 Saccharomyces cerevisiae Arg5,6p NP_010992.1 295408 D 4932 CDS NP_010993.1 6320914 856801 298948..301614 1 NC_001137.2 Rnr1p; Ribonucleotide-diphosphate reductase (RNR), large subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits 301614 RNR1 856801 RNR1 Saccharomyces cerevisiae Ribonucleotide-diphosphate reductase (RNR), large subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits NP_010993.1 298948 D 4932 CDS NP_010994.1 6320915 856802 complement(301945..302325) 1 NC_001137.2 Yer071cp; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 302325 856802 YER071C Saccharomyces cerevisiae Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern NP_010994.1 301945 R 4932 CDS NP_010995.1 6320916 856803 302804..303193 1 NC_001137.2 Vtc1p; Vacuolar transporter chaperon (VTC) involved in distributing V-ATPase and other membrane proteins; together with other VTC proteins, forms a heterotetrameric complex that associates with the SNARE Nyv1p and the V0 sector of the V-ATPase 303193 VTC1 856803 VTC1 Saccharomyces cerevisiae Vacuolar transporter chaperon (VTC) involved in distributing V-ATPase and other membrane proteins; together with other VTC proteins, forms a heterotetrameric complex that associates with the SNARE Nyv1p and the V0 sector of the V-ATPase NP_010995.1 302804 D 4932 CDS NP_010996.1 6320917 856804 304027..305589 1 NC_001137.2 Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed; Ald5p 305589 ALD5 856804 ALD5 Saccharomyces cerevisiae Ald5p NP_010996.1 304027 D 4932 CDS NP_010997.1 6320918 856805 join(306319..306321,306788..307192) 1 NC_001137.2 Rps24ap; Protein component of the small (40S) ribosomal subunit; identical to Rps24Bp and has similarity to rat S24 ribosomal protein 307192 RPS24A 856805 RPS24A Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit; identical to Rps24Bp and has similarity to rat S24 ribosomal protein NP_010997.1 306319 D 4932 CDS NP_219496.2 41629682 856806 join(307649..307742,307845..307952,308064..308119) 1 NC_001137.2 Yos1p; Integral membrane protein required for ER to Golgi transport; localized to the Golgi, the ER, and COPII vesicles; interacts with Yip1p and Yif1p 308119 YOS1 856806 YOS1 Saccharomyces cerevisiae Integral membrane protein required for ER to Golgi transport; localized to the Golgi, the ER, and COPII vesicles; interacts with Yip1p and Yif1p NP_219496.2 307649 D 4932 CDS NP_010998.1 6320919 856807 complement(308409..311195) 1 NC_001137.2 Ptp3p; Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm 311195 PTP3 856807 PTP3 Saccharomyces cerevisiae Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm NP_010998.1 308409 R 4932 CDS NP_010999.1 6320920 856809 complement(312586..313494) 1 NC_001137.2 Yer076cp; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization 313494 856809 YER076C Saccharomyces cerevisiae Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization NP_010999.1 312586 R 4932 CDS NP_011000.1 6320921 856810 complement(314530..316596) 1 NC_001137.2 Yer077cp 316596 856810 YER077C Saccharomyces cerevisiae Yer077cp NP_011000.1 314530 R 4932 CDS NP_011001.1 6320922 856811 complement(316803..318338) 1 NC_001137.2 Yer078cp; Metallopeptidase, localized to the mitochondrial matrix 318338 856811 YER078C Saccharomyces cerevisiae Metallopeptidase, localized to the mitochondrial matrix NP_011001.1 316803 R 4932 CDS NP_878068.1 33438786 1466536 318642..318806 1 NC_001137.2 Yer078w-ap; Putative protein of unknown function; identified by fungal homology and RT-PCR 318806 1466536 YER078W-A Saccharomyces cerevisiae Putative protein of unknown function; identified by fungal homology and RT-PCR NP_878068.1 318642 D 4932 CDS NP_011002.1 6320923 856812 318916..319548 1 NC_001137.2 Yer079wp; Putative protein of unknown function 319548 856812 YER079W Saccharomyces cerevisiae Putative protein of unknown function NP_011002.1 318916 D 4932 CDS NP_011003.1 6320924 856813 319959..321842 1 NC_001137.2 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss (petite formation); Aim9p 321842 AIM9 856813 AIM9 Saccharomyces cerevisiae Aim9p NP_011003.1 319959 D 4932 CDS NP_011004.1 6320925 856814 322682..324091 1 NC_001137.2 Ser3p; 3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser33p 324091 SER3 856814 SER3 Saccharomyces cerevisiae 3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser33p NP_011004.1 322682 D 4932 CDS NP_011005.1 6320926 856815 complement(324268..325932) 1 NC_001137.2 Utp7p; Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA 325932 UTP7 856815 UTP7 Saccharomyces cerevisiae Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA NP_011005.1 324268 R 4932 CDS NP_011006.2 37362643 856817 complement(326170..327027) 1 NC_001137.2 Subunit of the GET complex; required for meiotic nuclear division and for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion; may be involved in cell wall function; Get2p 327027 GET2 856817 GET2 Saccharomyces cerevisiae Get2p NP_011006.2 326170 R 4932 CDS NP_011008.1 6320929 856818 complement(327615..328136) 1 NC_001137.2 Yer085cp; Putative protein of unknown function 328136 856818 YER085C Saccharomyces cerevisiae Putative protein of unknown function NP_011008.1 327615 R 4932 CDS NP_011009.1 6320930 856819 328473..330203 1 NC_001137.2 Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation; Ilv1p 330203 ILV1 856819 ILV1 Saccharomyces cerevisiae Ilv1p NP_011009.1 328473 D 4932 CDS NP_011010.1 6320931 856820 330572..332302 1 NC_001137.2 Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant displays decreased frequency of mitochondrial genome loss (petite formation), severe growth defect in minimal glycerol media; Aim10p 332302 AIM10 856820 AIM10 Saccharomyces cerevisiae Aim10p NP_011010.1 330572 D 4932 CDS NP_011011.1 6320932 856821 complement(332578..332826) 1 NC_001137.2 Sbh1p; Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; homologous to Sbh2p 332826 SBH1 856821 SBH1 Saccharomyces cerevisiae Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; homologous to Sbh2p NP_011011.1 332578 R 4932 CDS NP_011012.1 6320933 856822 complement(333172..335184) 1 NC_001137.2 Protein of unknown function, involved in telomeric gene silencing and filamentation; Dot6p 335184 DOT6 856822 DOT6 Saccharomyces cerevisiae Dot6p NP_011012.1 333172 R 4932 CDS NP_011013.1 6320934 856823 complement(335942..337336) 1 NC_001137.2 Type 2C protein phosphatase; dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; role in DNA checkpoint inactivation; Ptc2p 337336 PTC2 856823 PTC2 Saccharomyces cerevisiae Ptc2p NP_011013.1 335942 R 4932 CDS NP_011014.1 6320935 856824 337945..339468 1 NC_001137.2 Trp2p; Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p 339468 TRP2 856824 TRP2 Saccharomyces cerevisiae Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p NP_011014.1 337945 D 4932 CDS NP_011015.1 6320936 856825 complement(339860..342163) 1 NC_001137.2 Met6p; Cobalamin-independent methionine synthase, involved in amino acid biosynthesis; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs 342163 MET6 856825 MET6 Saccharomyces cerevisiae Cobalamin-independent methionine synthase, involved in amino acid biosynthesis; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs NP_011015.1 339860 R 4932 CDS NP_011017.1 6320938 856827 342851..343228 1 NC_001137.2 Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; Ies5p 343228 IES5 856827 IES5 Saccharomyces cerevisiae Ies5p NP_011017.1 342851 D 4932 CDS NP_011018.1 6320939 856828 complement(343316..347608) 1 NC_001137.2 Tsc11p; Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain 347608 TSC11 856828 TSC11 Saccharomyces cerevisiae Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain NP_011018.1 343316 R 4932 CDS NP_011019.1 6320940 856829 complement(join(347908..348197,348273..348396)) 1 NC_001137.2 Putative protein of unknown function; YER093C-A contains an intron; null mutant displays increased frequency of mitochondrial genome loss (petite formation); Aim11p 348396 AIM11 856829 AIM11 Saccharomyces cerevisiae Aim11p NP_011019.1 347908 R 4932 CDS NP_011020.1 6320941 856830 complement(348725..349342) 1 NC_001137.2 Pup3p; Beta subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10 349342 PUP3 856830 PUP3 Saccharomyces cerevisiae Beta subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10 NP_011020.1 348725 R 4932 CDS NP_011021.1 6320942 856831 349976..351178 1 NC_001137.2 Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein; Rad51p 351178 RAD51 856831 RAD51 Saccharomyces cerevisiae Rad51p NP_011021.1 349976 D 4932 CDS NP_011022.1 6320943 856832 351694..353232 1 NC_001137.2 Sporulation-specific activator of Chs3p (chitin synthase III), required for the synthesis of the chitosan layer of ascospores; has similarity to Skt5p, which activates Chs3p during vegetative growth; transcriptionally induced at alkaline pH; Shc1p 353232 SHC1 856832 SHC1 Saccharomyces cerevisiae Shc1p NP_011022.1 351694 D 4932 CDS NP_011024.1 6320945 856835 355462..357726 1 NC_001137.2 Ubp9p; Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease that cleaves ubiquitin-protein fusions 357726 UBP9 856835 UBP9 Saccharomyces cerevisiae Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease that cleaves ubiquitin-protein fusions NP_011024.1 355462 D 4932 CDS NP_011025.1 6320946 856836 complement(358101..359057) 1 NC_001137.2 Prs2p; 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involved in nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes 359057 PRS2 856836 PRS2 Saccharomyces cerevisiae 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involved in nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes NP_011025.1 358101 R 4932 CDS NP_011026.1 6320947 856837 359558..360310 1 NC_001137.2 Ubiquitin-conjugating enzyme involved in ER-associated protein degradation; located at the cytosolic side of the ER membrane; tail region contains a transmembrane segment at the C-terminus; substrate of the ubiquitin-proteasome pathway; Ubc6p 360310 UBC6 856837 UBC6 Saccharomyces cerevisiae Ubc6p NP_011026.1 359558 D 4932 CDS NP_011027.1 6320948 856838 complement(360498..361790) 1 NC_001137.2 Protein that may have a role in targeting of plasma membrane [H+]ATPase (Pma1p) to the plasma membrane, as suggested by analysis of genetic interactions; Ast2p 361790 AST2 856838 AST2 Saccharomyces cerevisiae Ast2p NP_011027.1 360498 R 4932 CDS NP_011028.1 6320949 856839 363096..363698 1 NC_001137.2 Rps8bp; Protein component of the small (40S) ribosomal subunit; identical to Rps8Ap and has similarity to rat S8 ribosomal protein 363698 RPS8B 856839 RPS8B Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit; identical to Rps8Ap and has similarity to rat S8 ribosomal protein NP_011028.1 363096 D 4932 CDS NP_011029.1 6320950 856840 364585..366513 1 NC_001137.2 Ssa4p; Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation 366513 SSA4 856840 SSA4 Saccharomyces cerevisiae Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation NP_011029.1 364585 D 4932 CDS NP_011030.1 6320951 856841 366798..367424 1 NC_001137.2 Rtt105p; Protein with a role in regulation of Ty1 transposition 367424 RTT105 856841 RTT105 Saccharomyces cerevisiae Protein with a role in regulation of Ty1 transposition NP_011030.1 366798 D 4932 CDS NP_011031.1 6320952 856842 complement(367834..372009) 1 NC_001137.2 Nup157p; Abundant subunit of the nuclear pore complex (NPC), present on both sides of the NPC, has similarity to Nup170p 372009 NUP157 856842 NUP157 Saccharomyces cerevisiae Abundant subunit of the nuclear pore complex (NPC), present on both sides of the NPC, has similarity to Nup170p NP_011031.1 367834 R 4932 CDS NP_011032.1 6320953 856843 372322..373230 1 NC_001137.2 Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle; Mam1p 373230 MAM1 856843 MAM1 Saccharomyces cerevisiae Mam1p NP_011032.1 372322 D 4932 CDS NP_011033.1 6320954 856844 complement(373444..374541) 1 NC_001137.2 Gle2p; Component of the nuclear pore complex required for polyadenylated RNA export but not for protein import, homologous to S. pombe Rae1p 374541 GLE2 856844 GLE2 Saccharomyces cerevisiae Component of the nuclear pore complex required for polyadenylated RNA export but not for protein import, homologous to S. pombe Rae1p NP_011033.1 373444 R 4932 CDS NP_011034.1 6320955 856845 complement(375211..377610) 1 NC_001137.2 Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene; Flo8p 377610 FLO8 856845 FLO8 Saccharomyces cerevisiae Flo8p NP_011034.1 375211 R 4932 CDS NP_011035.1 6320956 856846 complement(378758..382099) 1 NC_001137.2 Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1; Kap123p 382099 KAP123 856846 KAP123 Saccharomyces cerevisiae Kap123p NP_011035.1 378758 R 4932 CDS NP_011036.1 6320957 856847 complement(382591..385872) 1 NC_001137.2 Swi4p; DNA binding component of the SBF complex (Swi4p-Swi6p), a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair 385872 SWI4 856847 SWI4 Saccharomyces cerevisiae DNA binding component of the SBF complex (Swi4p-Swi6p), a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair NP_011036.1 382591 R 4932 CDS NP_011037.1 6320958 856848 387228..387791 1 NC_001137.2 Lsm4p; Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA 387791 LSM4 856848 LSM4 Saccharomyces cerevisiae Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA NP_011037.1 387228 D 4932 CDS NP_011038.1 6320959 856849 complement(387928..390048) 1 NC_001137.2 Tmn3p; Non-essential golgi localized protein of unknown function; contains niine potential transmembrane domains and has similarity to the endosomal protein, Emp70p 390048 TMN3 856849 TMN3 Saccharomyces cerevisiae Non-essential golgi localized protein of unknown function; contains niine potential transmembrane domains and has similarity to the endosomal protein, Emp70p NP_011038.1 387928 R 4932 CDS NP_011039.1 6320960 856850 complement(390586..393708) 1 NC_001137.2 Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; Boi2p 393708 BOI2 856850 BOI2 Saccharomyces cerevisiae Boi2p NP_011039.1 390586 R 4932 CDS NP_011040.1 6320961 856851 complement(394288..394863) 1 NC_001137.2 Spr6p; Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation 394863 SPR6 856851 SPR6 Saccharomyces cerevisiae Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation NP_011040.1 394288 R 4932 CDS NP_011041.1 6320962 856852 complement(395344..396168) 1 NC_001137.2 Subunit of the Slx5-Slx8 substrate-specific ubiquitin ligase complex; stimulated by prior attachment of SUMO to the substrate; Slx8p 396168 SLX8 856852 SLX8 Saccharomyces cerevisiae Slx8p NP_011041.1 395344 R 4932 CDS NP_011042.1 6320963 856853 join(396765..396806,397278..397649) 1 NC_001137.2 Rpl23bp; Protein component of the large (60S) ribosomal subunit, identical to Rpl23Ap and has similarity to E. coli L14 and rat L23 ribosomal proteins 397649 RPL23B 856853 RPL23B Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, identical to Rpl23Ap and has similarity to E. coli L14 and rat L23 ribosomal proteins NP_011042.1 396765 D 4932 CDS NP_011043.1 6320964 856854 complement(397948..399051) 1 NC_001137.2 Transmembrane osmosensor, participates in activation of both the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; Sho1p 399051 SHO1 856854 SHO1 Saccharomyces cerevisiae Sho1p NP_011043.1 397948 R 4932 CDS NP_011044.1 6320965 856855 complement(399492..400838) 1 NC_001137.2 Vacuolar amino acid transporter, exports aspartate and glutamate from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; Avt6p 400838 AVT6 856855 AVT6 Saccharomyces cerevisiae Avt6p NP_011044.1 399492 R 4932 CDS NP_011046.1 6320966 856856 401131..401865 1 NC_001137.2 Scs2p; Integral ER membrane protein that regulates phospholipid metabolism via an interaction with the FFAT motif of Opi1p, also involved in telomeric silencing, disruption causes inositol auxotrophy above 34 degrees C, VAP homolog 401865 SCS2 856856 SCS2 Saccharomyces cerevisiae Integral ER membrane protein that regulates phospholipid metabolism via an interaction with the FFAT motif of Opi1p, also involved in telomeric silencing, disruption causes inositol auxotrophy above 34 degrees C, VAP homolog NP_011046.1 401131 D 4932 CDS NP_011047.1 6320968 856858 402371..402715 1 NC_001137.2 Yer121wp; Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy 402715 856858 YER121W Saccharomyces cerevisiae Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy NP_011047.1 402371 D 4932 CDS NP_011048.1 6320969 856859 complement(402867..404348) 1 NC_001137.2 Glo3p; ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p 404348 GLO3 856859 GLO3 Saccharomyces cerevisiae ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p NP_011048.1 402867 R 4932 CDS NP_011049.2 7276233 856860 404809..406383 1 NC_001137.2 Yck3p; Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of the HOPS complex subunit, Vps41p; shares overlapping essential functions with Hrr25p 406383 YCK3 856860 YCK3 Saccharomyces cerevisiae Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of the HOPS complex subunit, Vps41p; shares overlapping essential functions with Hrr25p NP_011049.2 404809 D 4932 CDS NP_011050.1 6320971 856861 complement(407338..409059) 1 NC_001137.2 Dse1p; Daughter cell-specific protein, may participate in pathways regulating cell wall metabolism; deletion affects cell separation after division and sensitivity to drugs targeted against the cell wall 409059 DSE1 856861 DSE1 Saccharomyces cerevisiae Daughter cell-specific protein, may participate in pathways regulating cell wall metabolism; deletion affects cell separation after division and sensitivity to drugs targeted against the cell wall NP_011050.1 407338 R 4932 CDS NP_011051.1 6320972 856862 410185..412614 1 NC_001137.2 Ubiquitin-protein ligase involved in ubiquitin-mediated protein degradation; functions in multivesicular body sorting, heat shock response and ubiquitylation of arrested RNAPII; contains a hect (homologous to E6-AP carboxyl terminus) domain; Rsp5p 412614 RSP5 856862 RSP5 Saccharomyces cerevisiae Rsp5p NP_011051.1 410185 D 4932 CDS NP_011052.1 6320973 856863 complement(413390..414175) 1 NC_001137.2 Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA; Nsa2p 414175 NSA2 856863 NSA2 Saccharomyces cerevisiae Nsa2p NP_011052.1 413390 R 4932 CDS NP_011053.1 6320974 856864 414477..415550 1 NC_001137.2 Lcp5p; Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus 415550 LCP5 856864 LCP5 Saccharomyces cerevisiae Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus NP_011053.1 414477 D 4932 CDS NP_011054.1 6320975 856865 415855..416466 1 NC_001137.2 Yer128wp; Putative protein of unknown function 416466 856865 YER128W Saccharomyces cerevisiae Putative protein of unknown function NP_011054.1 415855 D 4932 CDS NP_011055.1 6320976 856866 417277..420705 1 NC_001137.2 Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome; Sak1p 420705 SAK1 856866 SAK1 Saccharomyces cerevisiae Sak1p NP_011055.1 417277 D 4932 CDS NP_011056.1 6320977 856867 complement(421111..422442) 1 NC_001137.2 Yer130cp 422442 856867 YER130C Saccharomyces cerevisiae Yer130cp NP_011056.1 421111 R 4932 CDS NP_011057.1 6320978 856868 423948..424307 1 NC_001137.2 Rps26bp; Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein 424307 RPS26B 856868 RPS26B Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein NP_011057.1 423948 D 4932 CDS NP_011058.1 6320979 856869 complement(425184..430445) 1 NC_001137.2 Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Mds3p, for growth under alkaline conditions; Pmd1p 430445 PMD1 856869 PMD1 Saccharomyces cerevisiae Pmd1p NP_011058.1 425184 R 4932 CDS NP_011059.1 6320980 856870 join(432491..432667,433193..433954) 1 NC_001137.2 Glc7p; Catalytic subunit of type 1 serine/threonine protein phosphatase, involved in many processes including glycogen metabolism, sporulation, and mitosis; interacts with multiple regulatory subunits; predominantly isolated with Sds22p 433954 GLC7 856870 GLC7 Saccharomyces cerevisiae Catalytic subunit of type 1 serine/threonine protein phosphatase, involved in many processes including glycogen metabolism, sporulation, and mitosis; interacts with multiple regulatory subunits; predominantly isolated with Sds22p NP_011059.1 432491 D 4932 CDS NP_011060.1 6320981 856873 complement(437263..437799) 1 NC_001137.2 Yer134cp; Putative protein of unknown function; non-essential gene 437799 856873 YER134C Saccharomyces cerevisiae Putative protein of unknown function; non-essential gene NP_011060.1 437263 R 4932 CDS NP_011062.1 6320983 856876 439612..440967 1 NC_001137.2 Gdi1p; GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins 440967 GDI1 856876 GDI1 Saccharomyces cerevisiae GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins NP_011062.1 439612 D 4932 CDS NP_011063.1 6320984 856877 complement(441369..441815) 1 NC_001137.2 Yer137cp; Putative protein of unknown function 441815 856877 YER137C Saccharomyces cerevisiae Putative protein of unknown function NP_011063.1 441369 R 4932 CDS NP_011064.1 6320985 856879 complement(join(443752..447717,447719..449020)) 1 NC_001137.2 Yer138cp; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 449020 856879 YER138C Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_011064.1 443752 R 4932 CDS NP_058155.1 7839167 856880 complement(447698..449020) 1 NC_001137.2 Yer137c-ap; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 449020 856880 YER137C-A Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_058155.1 447698 R 4932 CDS NP_011065.1 6320986 856881 449470..449574 1 NC_001137.2 Yer138w-ap; Putative protein of unknown function 449574 856881 YER138W-A Saccharomyces cerevisiae Putative protein of unknown function NP_011065.1 449470 D 4932 CDS NP_011066.1 6320987 856882 complement(450558..451238) 1 NC_001137.2 Rtr1p; Putative protein of unknown function; YER139C has been shown to be required for growth at high temperatures; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 451238 RTR1 856882 RTR1 Saccharomyces cerevisiae Putative protein of unknown function; YER139C has been shown to be required for growth at high temperatures; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm NP_011066.1 450558 R 4932 CDS NP_011067.1 6320988 856883 451560..453230 1 NC_001137.2 Yer140wp; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 453230 856883 YER140W Saccharomyces cerevisiae Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_011067.1 451560 D 4932 CDS NP_011068.1 6320989 856884 453454..454914 1 NC_001137.2 Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase; Cox15p 454914 COX15 856884 COX15 Saccharomyces cerevisiae Cox15p NP_011068.1 453454 D 4932 CDS NP_011069.1 6320990 856885 complement(455141..456031) 1 NC_001137.2 Mag1p; 3-methyl-adenine DNA glycosylase involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired 456031 MAG1 856885 MAG1 Saccharomyces cerevisiae 3-methyl-adenine DNA glycosylase involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired NP_011069.1 455141 R 4932 CDS NP_011070.1 6320991 856886 456314..457600 1 NC_001137.2 Ddi1p; DNA damage-inducible v-SNARE binding protein, contains a ubiquitin-associated (UBA) domain, may act as a negative regulator of constitutive exocytosis, may play a role in S-phase checkpoint control 457600 DDI1 856886 DDI1 Saccharomyces cerevisiae DNA damage-inducible v-SNARE binding protein, contains a ubiquitin-associated (UBA) domain, may act as a negative regulator of constitutive exocytosis, may play a role in S-phase checkpoint control NP_011070.1 456314 D 4932 CDS NP_011071.1 6320992 856887 complement(457801..460218) 1 NC_001137.2 Ubp5p; Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concentrates at the bud neck 460218 UBP5 856887 UBP5 Saccharomyces cerevisiae Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concentrates at the bud neck NP_011071.1 457801 R 4932 CDS NP_011072.1 6320993 856888 complement(460521..461735) 1 NC_001137.2 High affinity iron permease involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; Ftr1p 461735 FTR1 856888 FTR1 Saccharomyces cerevisiae Ftr1p NP_011072.1 460521 R 4932 CDS NP_011073.1 6320994 856889 462580..462861 1 NC_001137.2 Lsm5p; Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA 462861 LSM5 856889 LSM5 Saccharomyces cerevisiae Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA NP_011073.1 462580 D 4932 CDS NP_011074.1 6320995 856890 complement(462963..464837) 1 NC_001137.2 Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX; Scc4p 464837 SCC4 856890 SCC4 Saccharomyces cerevisiae Scc4p NP_011074.1 462963 R 4932 CDS NP_011075.1 6320996 856891 465298..466020 1 NC_001137.2 TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability; Spt15p 466020 SPT15 856891 SPT15 Saccharomyces cerevisiae Spt15p NP_011075.1 465298 D 4932 CDS NP_011076.1 6320997 856892 complement(466203..467465) 1 NC_001137.2 Pea2p; Coiled-coil polarisome protein required for polarized morphogenesis, cell fusion, and low affinity Ca2+ influx; forms polarisome complex with Bni1p, Bud6p, and Spa2p; localizes to sites of polarized growth 467465 PEA2 856892 PEA2 Saccharomyces cerevisiae Coiled-coil polarisome protein required for polarized morphogenesis, cell fusion, and low affinity Ca2+ influx; forms polarisome complex with Bni1p, Bud6p, and Spa2p; localizes to sites of polarized growth NP_011076.1 466203 R 4932 CDS NP_011077.1 6320998 856893 468365..468811 1 NC_001137.2 Spi1p; GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p 468811 SPI1 856893 SPI1 Saccharomyces cerevisiae GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p NP_011077.1 468365 D 4932 CDS NP_011078.1 6320999 856895 complement(469681..472419) 1 NC_001137.2 Ubp3p; Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between endoplasmic reticulum and Golgi compartments; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin 472419 UBP3 856895 UBP3 Saccharomyces cerevisiae Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between endoplasmic reticulum and Golgi compartments; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin NP_011078.1 469681 R 4932 CDS NP_011079.1 6321000 856896 complement(472652..473983) 1 NC_001137.2 Yer152cp; Putative protein of unknown function; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene 473983 856896 YER152C Saccharomyces cerevisiae Putative protein of unknown function; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene NP_011079.1 472652 R 4932 CDS NP_011080.1 6321001 856897 complement(474036..474800) 1 NC_001137.2 Pet122p; Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane 474800 PET122 856897 PET122 Saccharomyces cerevisiae Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane NP_011080.1 474036 R 4932 CDS NP_011081.1 6321002 856898 475015..476223 1 NC_001137.2 Oxa1p; Mitochondrial inner membrane insertase, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; conserved from bacteria to animals 476223 OXA1 856898 OXA1 Saccharomyces cerevisiae Mitochondrial inner membrane insertase, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; conserved from bacteria to animals NP_011081.1 475015 D 4932 CDS NP_011082.1 6321003 856899 complement(476340..482843) 1 NC_001137.2 Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence; Bem2p 482843 BEM2 856899 BEM2 Saccharomyces cerevisiae Bem2p NP_011082.1 476340 R 4932 CDS NP_011083.1 6321004 856900 complement(483320..484336) 1 NC_001137.2 Yer156cp; Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus 484336 856900 YER156C Saccharomyces cerevisiae Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus NP_011083.1 483320 R 4932 CDS NP_011084.1 6321005 856901 484783..487188 1 NC_001137.2 Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; Cog3p 487188 COG3 856901 COG3 Saccharomyces cerevisiae Cog3p NP_011084.1 484783 D 4932 CDS NP_011085.1 6321006 856903 complement(488852..490573) 1 NC_001137.2 Yer158cp; Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p 490573 856903 YER158C Saccharomyces cerevisiae Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p NP_011085.1 488852 R 4932 CDS NP_011086.1 6321007 856904 complement(491525..491953) 1 NC_001137.2 Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha; Bur6p 491953 BUR6 856904 BUR6 Saccharomyces cerevisiae Bur6p NP_011086.1 491525 R 4932 CDS NP_011087.1 6321008 856906 complement(join(492851..496816,496818..498119)) 1 NC_001137.2 Yer160cp; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 498119 856906 YER160C Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_011087.1 492851 R 4932 CDS NP_058156.1 7839168 856907 complement(496797..498119) 1 NC_001137.2 Yer159c-ap; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 498119 856907 YER159C-A Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_058156.1 496797 R 4932 CDS NP_011088.1 6321009 856908 complement(499342..500343) 1 NC_001137.2 Spt2p; Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins 500343 SPT2 856908 SPT2 Saccharomyces cerevisiae Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins NP_011088.1 499342 R 4932 CDS NP_011089.1 6321010 856909 complement(500625..502889) 1 NC_001137.2 Rad4p; Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human XPC protein 502889 RAD4 856909 RAD4 Saccharomyces cerevisiae Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human XPC protein NP_011089.1 500625 R 4932 CDS NP_011090.1 6321011 856910 complement(503079..503777) 1 NC_001137.2 Yer163cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus 503777 856910 YER163C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus NP_011090.1 503079 R 4932 CDS NP_011091.1 6321012 856911 505387..509793 1 NC_001137.2 Nucleosome remodeling factor that functions in regulation of transcription elongation; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SILK complexes; Chd1p 509793 CHD1 856911 CHD1 Saccharomyces cerevisiae Chd1p NP_011091.1 505387 D 4932 CDS NP_011092.1 6321013 856912 510368..512101 1 NC_001137.2 Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G; Pab1p 512101 PAB1 856912 PAB1 Saccharomyces cerevisiae Pab1p NP_011092.1 510368 D 4932 CDS NP_011093.1 6321014 856913 512739..517454 1 NC_001137.2 Dnf1p; Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase 517454 DNF1 856913 DNF1 Saccharomyces cerevisiae Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase NP_011093.1 512739 D 4932 CDS NP_011094.1 6321015 856914 518211..520766 1 NC_001137.2 Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations; Bck2p 520766 BCK2 856914 BCK2 Saccharomyces cerevisiae Bck2p NP_011094.1 518211 D 4932 CDS NP_011095.1 6321016 856915 complement(521024..522664) 1 NC_001137.2 Cca1p; ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites 522664 CCA1 856915 CCA1 Saccharomyces cerevisiae ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites NP_011095.1 521024 R 4932 CDS NP_011096.1 6321017 856916 523364..525754 1 NC_001137.2 Rph1p; JmjC domain-containing histone demethylase which can specifically demethylate H3K36 tri- and dimethyl modification states; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway 525754 RPH1 856916 RPH1 Saccharomyces cerevisiae JmjC domain-containing histone demethylase which can specifically demethylate H3K36 tri- and dimethyl modification states; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway NP_011096.1 523364 D 4932 CDS NP_011097.1 6321018 856917 525969..526646 1 NC_001137.2 Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background; Adk2p 526646 ADK2 856917 ADK2 Saccharomyces cerevisiae Adk2p NP_011097.1 525969 D 4932 CDS NP_011098.1 6321019 856918 527077..529413 1 NC_001137.2 Rad3p; 5' to 3' DNA helicase, involved in nucleotide excision repair and transcription; subunit of RNA polymerase II transcription initiation factor TFIIH; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein 529413 RAD3 856918 RAD3 Saccharomyces cerevisiae 5' to 3' DNA helicase, involved in nucleotide excision repair and transcription; subunit of RNA polymerase II transcription initiation factor TFIIH; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein NP_011098.1 527077 D 4932 CDS NP_011099.1 6321020 856919 complement(529525..536016) 1 NC_001137.2 RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD; Brr2p 536016 BRR2 856919 BRR2 Saccharomyces cerevisiae Brr2p NP_011099.1 529525 R 4932 CDS NP_011100.1 6321021 856920 536295..538274 1 NC_001137.2 Rad24p; Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein 538274 RAD24 856920 RAD24 Saccharomyces cerevisiae Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein NP_011100.1 536295 D 4932 CDS NP_011101.1 6321022 856921 complement(538429..539163) 1 NC_001137.2 Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage; Grx4p 539163 GRX4 856921 GRX4 Saccharomyces cerevisiae Grx4p NP_011101.1 538429 R 4932 CDS NP_011102.1 6321023 856922 complement(539459..540358) 1 NC_001137.2 Trans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle; Tmt1p 540358 TMT1 856922 TMT1 Saccharomyces cerevisiae Tmt1p NP_011102.1 539459 R 4932 CDS NP_878069.1 33438787 1466537 540645..540809 1 NC_001137.2 Yer175w-ap; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 540809 1466537 YER175W-A Saccharomyces cerevisiae Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching NP_878069.1 540645 D 4932 CDS NP_011103.1 6321024 856923 541685..545050 1 NC_001137.2 Ecm32p; DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes 545050 ECM32 856923 ECM32 Saccharomyces cerevisiae DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes NP_011103.1 541685 D 4932 CDS NP_011104.1 6321025 856924 545606..546409 1 NC_001137.2 Bmh1p; 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling 546409 BMH1 856924 BMH1 Saccharomyces cerevisiae 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling NP_011104.1 545606 D 4932 CDS NP_011105.2 37362644 856925 546812..548074 1 NC_001137.2 Pda1p; E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose 548074 PDA1 856925 PDA1 Saccharomyces cerevisiae E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose NP_011105.2 546812 D 4932 CDS NP_011106.1 6321027 856926 join(548416..548547,548640..549512) 1 NC_001137.2 Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein; Dmc1p 549512 DMC1 856926 DMC1 Saccharomyces cerevisiae Dmc1p NP_011106.1 548416 D 4932 CDS NP_011107.1 6321028 856927 complement(549719..550522) 1 NC_001137.2 Protein required for sporulation, transcript is induced 7.5 hours after induction of meiosis, expected to play significant role in the formation of reproductive cells; Isc10p 550522 ISC10 856927 ISC10 Saccharomyces cerevisiae Isc10p NP_011107.1 549719 R 4932 CDS NP_796378.1 28913320 856928 complement(550860..551117) 1 NC_001137.2 Slo1p; Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO 551117 SLO1 856928 SLO1 Saccharomyces cerevisiae Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO NP_796378.1 550860 R 4932 CDS NP_011109.1 6321030 856931 552520..553254 1 NC_001137.2 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Fmp10p 553254 FMP10 856931 FMP10 Saccharomyces cerevisiae Fmp10p NP_011109.1 552520 D 4932 CDS NP_011110.1 6321031 856932 complement(553329..553964) 1 NC_001137.2 Fau1p; 5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis 553964 FAU1 856932 FAU1 Saccharomyces cerevisiae 5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis NP_011110.1 553329 R 4932 CDS NP_011111.1 6321032 856933 complement(556291..558675) 1 NC_001137.2 Yer184cp; Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source 558675 856933 YER184C Saccharomyces cerevisiae Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source NP_011111.1 556291 R 4932 CDS NP_011112.1 6321033 856934 559449..560360 1 NC_001137.2 Pug1p; Plasma membrane protein involved in protoporphyrin uptake; similar in sequence to RSB1, which is involved in sphingoid long-chain base release 560360 PUG1 856934 PUG1 Saccharomyces cerevisiae Plasma membrane protein involved in protoporphyrin uptake; similar in sequence to RSB1, which is involved in sphingoid long-chain base release NP_011112.1 559449 D 4932 CDS NP_011113.1 6321034 856935 complement(561700..562620) 1 NC_001137.2 Yer186cp; Putative protein of unknown function 562620 856935 YER186C Saccharomyces cerevisiae Putative protein of unknown function NP_011113.1 561700 R 4932 CDS NP_011114.1 6321035 856937 566225..566650 1 NC_001137.2 Yer187wp; Putative protein of unknown function; induced in respiratory-deficient cells 566650 856937 YER187W Saccharomyces cerevisiae Putative protein of unknown function; induced in respiratory-deficient cells NP_011114.1 566225 D 4932 CDS NP_878070.1 33438788 1466538 complement(569603..569902) 1 NC_001137.2 Yer188c-ap; Putative protein of unknown function 569902 1466538 YER188C-A Saccharomyces cerevisiae Putative protein of unknown function NP_878070.1 569603 R 4932 CDS NP_011116.1 6321037 856939 571150..571518 1 NC_001137.2 Yer189wp; Putative protein of unknown function 571518 856939 YER189W Saccharomyces cerevisiae Putative protein of unknown function NP_011116.1 571150 D 4932 CDS NP_011117.1 6321038 856940 571475..576520 1 NC_001137.2 Yrf1-2p; Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p 576520 YRF1-2 856940 YRF1-2 Saccharomyces cerevisiae Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p NP_011117.1 571475 D 4932 CDS NP_001073292.1 119524037 4594642 complement(575675..576157) 1 NC_001137.2 Yer190c-bp; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 576157 4594642 YER190C-B Saccharomyces cerevisiae Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching NP_001073292.1 575675 R 4932 CDS NP_116587.1 14318451 850476 53..535 1 NC_001138.4 Yfl068wp; Putative protein of unknown function 535 850476 YFL068W Saccharomyces cerevisiae Putative protein of unknown function NP_116587.1 53 D 4932 CDS NP_116588.1 14318452 850477 836..1363 1 NC_001138.4 Yfl067wp; Protein of unknown function, down-regulated at low calcium levels 1363 850477 YFL067W Saccharomyces cerevisiae Protein of unknown function, down-regulated at low calcium levels NP_116588.1 836 D 4932 CDS NP_116589.1 14318453 850478 complement(1437..2615) 1 NC_001138.4 Yfl066cp; Helicase-like protein encoded within the telomeric Y' element 2615 850478 YFL066C Saccharomyces cerevisiae Helicase-like protein encoded within the telomeric Y' element NP_116589.1 1437 R 4932 CDS NP_116590.1 14318454 850479 complement(3030..3338) 1 NC_001138.4 Yfl065cp; Putative protein of unknown function 3338 850479 YFL065C Saccharomyces cerevisiae Putative protein of unknown function NP_116590.1 3030 R 4932 CDS NP_116591.1 14318455 850480 complement(3322..3846) 1 NC_001138.4 Yfl064cp; Putative protein of unknown function 3846 850480 YFL064C Saccharomyces cerevisiae Putative protein of unknown function NP_116591.1 3322 R 4932 CDS NP_116593.1 14318457 850482 6426..7565 1 NC_001138.4 Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; Cos4p 7565 COS4 850482 COS4 Saccharomyces cerevisiae Cos4p NP_116593.1 6426 D 4932 CDS NP_116594.1 14318458 850483 9545..10222 1 NC_001138.4 Protein whose expression is induced by DNA damage; Ddi2p 10222 DDI2 850483 DDI2 Saccharomyces cerevisiae Ddi2p NP_116594.1 9545 D 4932 CDS NP_116595.1 14318459 850484 complement(10301..10969) 1 NC_001138.4 Sno3p; Protein of unknown function, nearly identical to Sno2p; expression is induced before the diauxic shift and also in the absence of thiamin 10969 SNO3 850484 SNO3 Saccharomyces cerevisiae Protein of unknown function, nearly identical to Sno2p; expression is induced before the diauxic shift and also in the absence of thiamin NP_116595.1 10301 R 4932 CDS NP_116596.1 14318460 850485 11363..12259 1 NC_001138.4 Snz3p; Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO3 12259 SNZ3 850485 SNZ3 Saccharomyces cerevisiae Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO3 NP_116596.1 11363 D 4932 CDS NP_116597.1 14318461 850486 12929..13951 1 NC_001138.4 Thi5p; Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13 13951 THI5 850486 THI5 Saccharomyces cerevisiae Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13 NP_116597.1 12929 D 4932 CDS NP_116598.1 14318462 850487 complement(14305..14763) 1 NC_001138.4 Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; Aad16p 14763 AAD16 850487 AAD16 Saccharomyces cerevisiae Aad16p NP_116598.1 14305 R 4932 CDS NP_116599.1 14318463 850488 complement(14793..15431) 1 NC_001138.4 Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase, involved in the oxidative stress response; Aad6p 15431 AAD6 850488 AAD6 Saccharomyces cerevisiae Aad6p NP_116599.1 14793 R 4932 CDS NP_116600.1 14318464 850489 17004..18680 1 NC_001138.4 Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; Agp3p 18680 AGP3 850489 AGP3 Saccharomyces cerevisiae Agp3p NP_116600.1 17004 D 4932 CDS NP_116601.1 14318465 850490 complement(20847..22787) 1 NC_001138.4 Yfl054cp; Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol 22787 850490 YFL054C Saccharomyces cerevisiae Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol NP_116601.1 20847 R 4932 CDS NP_116602.1 14318466 850491 23423..25198 1 NC_001138.4 Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation; Dak2p 25198 DAK2 850491 DAK2 Saccharomyces cerevisiae Dak2p NP_116602.1 23423 D 4932 CDS NP_116603.1 14318467 850492 28232..29629 1 NC_001138.4 Yfl052wp; Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity 29629 850492 YFL052W Saccharomyces cerevisiae Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity NP_116603.1 28232 D 4932 CDS NP_116576.1 14318468 850493 complement(30058..30540) 1 NC_001138.4 Yfl051cp; Putative protein of unknown function; YFL051C is not an essential gene 30540 850493 YFL051C Saccharomyces cerevisiae Putative protein of unknown function; YFL051C is not an essential gene NP_116576.1 30058 R 4932 CDS NP_116604.1 14318469 850494 complement(33272..35848) 1 NC_001138.4 Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; Alr2p 35848 ALR2 850494 ALR2 Saccharomyces cerevisiae Alr2p NP_116604.1 33272 R 4932 CDS NP_116605.1 14318470 850495 36803..38674 1 NC_001138.4 Swp82p; Member of the SWI/SNF chromatin remodeling complex in which it plays an as yet unidentified role; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p 38674 SWP82 850495 SWP82 Saccharomyces cerevisiae Member of the SWI/SNF chromatin remodeling complex in which it plays an as yet unidentified role; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p NP_116605.1 36803 D 4932 CDS NP_116606.1 14318471 850496 complement(38843..40180) 1 NC_001138.4 Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport; Emp47p 40180 EMP47 850496 EMP47 Saccharomyces cerevisiae Emp47p NP_116606.1 38843 R 4932 CDS NP_428268.1 16198342 850497 40421..42565 1 NC_001138.4 Rgd2p; GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p 42565 RGD2 850497 RGD2 Saccharomyces cerevisiae GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p NP_428268.1 40421 D 4932 CDS NP_116608.1 14318473 850498 42815..43438 1 NC_001138.4 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Fmp32p 43438 FMP32 850498 FMP32 Saccharomyces cerevisiae Fmp32p NP_116608.1 42815 D 4932 CDS NP_116609.1 14318474 850499 complement(43628..44392) 1 NC_001138.4 Sec53p; Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen 44392 SEC53 850499 SEC53 Saccharomyces cerevisiae Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen NP_116609.1 43628 R 4932 CDS NP_116610.1 14318475 850500 complement(44655..45560) 1 NC_001138.4 Otu1p; Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family 45560 OTU1 850500 OTU1 Saccharomyces cerevisiae Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family NP_116610.1 44655 R 4932 CDS NP_116611.1 14318476 850501 complement(45720..47744) 1 NC_001138.4 Yfl042cp; Putative protein of unknown function; YFL042C is not an essential gene 47744 850501 YFL042C Saccharomyces cerevisiae Putative protein of unknown function; YFL042C is not an essential gene NP_116611.1 45720 R 4932 CDS NP_878071.1 33438789 1466401 48734..48925 1 NC_001138.4 Yfl041w-ap; Putative protein of unknown function; identified by fungal homology and RT-PCR 48925 1466401 YFL041W-A Saccharomyces cerevisiae Putative protein of unknown function; identified by fungal homology and RT-PCR NP_878071.1 48734 D 4932 CDS NP_116612.1 14318477 850502 49139..51007 1 NC_001138.4 Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport; Fet5p 51007 FET5 850502 FET5 Saccharomyces cerevisiae Fet5p NP_116612.1 49139 D 4932 CDS NP_116613.1 14318478 850503 51350..52972 1 NC_001138.4 Yfl040wp; Putative transporter, member of the sugar porter family; YFL040W is not an essential gene 52972 850503 YFL040W Saccharomyces cerevisiae Putative transporter, member of the sugar porter family; YFL040W is not an essential gene NP_116613.1 51350 D 4932 CDS NP_116614.1 14318479 850504 complement(join(53260..54377,54686..54695)) 1 NC_001138.4 Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions; Act1p 54695 ACT1 850504 ACT1 Saccharomyces cerevisiae Act1p NP_116614.1 53260 R 4932 CDS NP_116615.1 14318480 850505 complement(55365..55985) 1 NC_001138.4 Ypt1p; Ras-like small GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p) 55985 YPT1 850505 YPT1 Saccharomyces cerevisiae Ras-like small GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p) NP_116615.1 55365 R 4932 CDS NP_116616.1 14318481 850506 56335..57708 1 NC_001138.4 Tub2p; Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules 57708 TUB2 850506 TUB2 Saccharomyces cerevisiae Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules NP_116616.1 56335 D 4932 CDS NP_116617.1 14318482 850507 58781..62836 1 NC_001138.4 Rpo41p; Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition 62836 RPO41 850507 RPO41 Saccharomyces cerevisiae Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition NP_116617.1 58781 D 4932 CDS NP_116618.1 14318483 850508 complement(join(63015..63858,63973..63992)) 1 NC_001138.4 Mob2p; Component of the RAM signaling network, localizes and activates the Ace2p in the daughter cell nucleus to direct daughter cell-specific transcription of several genes involved in cell separation; Mob1p-like protein 63992 MOB2 850508 MOB2 Saccharomyces cerevisiae Component of the RAM signaling network, localizes and activates the Ace2p in the daughter cell nucleus to direct daughter cell-specific transcription of several genes involved in cell separation; Mob1p-like protein NP_116618.1 63015 R 4932 CDS NP_116619.1 14318484 850509 complement(join(64242..64598,64920..64931)) 1 NC_001138.4 Rpl22bp; Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Ap and to rat L22 ribosomal protein 64931 RPL22B 850509 RPL22B Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Ap and to rat L22 ribosomal protein NP_116619.1 64242 R 4932 CDS NP_116583.1 14318485 850510 65475..68696 1 NC_001138.4 Yfl034wp; Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk 68696 850510 YFL034W Saccharomyces cerevisiae Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk NP_116583.1 65475 D 4932 CDS NP_116620.1 14318486 850511 complement(69113..74425) 1 NC_001138.4 Rim15p; Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase 74425 RIM15 850511 RIM15 Saccharomyces cerevisiae Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase NP_116620.1 69113 R 4932 CDS NP_116622.1 14318488 850513 join(75177..75837,76090..76145) 1 NC_001138.4 bZIP transcription factor (ATF/CREB1 homolog) that regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway utilizing Ire1p, Trl1p and Ada5p facilitates efficient Hac1p synthesis; Hac1p 76145 HAC1 850513 HAC1 Saccharomyces cerevisiae Hac1p NP_116622.1 75177 D 4932 CDS NP_116623.1 14318489 850514 76829..77986 1 NC_001138.4 Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases; Agx1p 77986 AGX1 850514 AGX1 Saccharomyces cerevisiae Agx1p NP_116623.1 76829 D 4932 CDS NP_116624.1 14318490 850515 complement(78053..79159) 1 NC_001138.4 Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases; Cak1p 79159 CAK1 850515 CAK1 Saccharomyces cerevisiae Cak1p NP_116624.1 78053 R 4932 CDS NP_116625.1 14318491 850516 complement(79342..80211) 1 NC_001138.4 Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation; putative ABC ATPase; interacts with Ssn2p, Ssn3p, and Ssn8p; Caf16p 80211 CAF16 850516 CAF16 Saccharomyces cerevisiae Caf16p NP_116625.1 79342 R 4932 CDS NP_444296.1 16740526 850517 complement(80417..81910) 1 NC_001138.4 Gyp8p; GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport 81910 GYP8 850517 GYP8 Saccharomyces cerevisiae GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport NP_444296.1 80417 R 4932 CDS NP_116627.1 14318493 850518 82578..83873 1 NC_001138.4 Ste2p; Receptor for alpha-factor pheromone; seven transmembrane-domain GPCR that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells 83873 STE2 850518 STE2 Saccharomyces cerevisiae Receptor for alpha-factor pheromone; seven transmembrane-domain GPCR that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells NP_116627.1 82578 D 4932 CDS NP_116628.1 14318494 850519 complement(84143..87232) 1 NC_001138.4 GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules; Bst1p 87232 BST1 850519 BST1 Saccharomyces cerevisiae Bst1p NP_116628.1 84143 R 4932 CDS NP_116629.1 14318495 850520 complement(87845..90343) 1 NC_001138.4 Epl1p; Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb 90343 EPL1 850520 EPL1 Saccharomyces cerevisiae Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb NP_116629.1 87845 R 4932 CDS NP_683715.1 22532997 850521 90984..93374 1 NC_001138.4 Protein involved in bud-site selection, nutrient signaling, and gene expression controlled by the TOR kinase; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; Bud27p 93374 BUD27 850521 BUD27 Saccharomyces cerevisiae Bud27p NP_683715.1 90984 D 4932 CDS NP_116631.1 14318497 850522 complement(93497..95008) 1 NC_001138.4 Frs2p; Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar 95008 FRS2 850522 FRS2 Saccharomyces cerevisiae Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar NP_116631.1 93497 R 4932 CDS NP_116632.1 14318498 850523 95964..97496 1 NC_001138.4 Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p; Gat1p 97496 GAT1 850523 GAT1 Saccharomyces cerevisiae Gat1p NP_116632.1 95964 D 4932 CDS NP_116633.1 14318499 850524 complement(99225..99593) 1 NC_001138.4 Pau5p; Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme 99593 PAU5 850524 PAU5 Saccharomyces cerevisiae Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme NP_116633.1 99225 R 4932 CDS NP_116635.1 14318501 850527 complement(101622..103121) 1 NC_001138.4 Lpd1p; Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes 103121 LPD1 850527 LPD1 Saccharomyces cerevisiae Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes NP_116635.1 101622 R 4932 CDS NP_116636.1 14318502 850528 103693..103926 1 NC_001138.4 Smx2p; Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G 103926 SMX2 850528 SMX2 Saccharomyces cerevisiae Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G NP_116636.1 103693 D 4932 CDS NP_116637.1 14318503 850529 complement(103977..104456) 1 NC_001138.4 Gna1p; Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA 104456 GNA1 850529 GNA1 Saccharomyces cerevisiae Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA NP_116637.1 103977 R 4932 CDS NP_116638.1 14318504 850530 complement(104695..106230) 1 NC_001138.4 Protein involved in folding of mitochondrially synthesized proteins in the mitochondrial matrix; localizes to the mitochondrial inner membrane; member of the DnaJ family of molecular chaperones; Mdj1p 106230 MDJ1 850530 MDJ1 Saccharomyces cerevisiae Mdj1p NP_116638.1 104695 R 4932 CDS NP_116640.1 14318506 850532 107250..107579 1 NC_001138.4 Plasma membrane localized protein that protects membranes from desiccation; induced by heat shock, oxidative stress, osmostress, stationary phase entry, glucose depletion, oleate and alcohol; regulated by the HOG and Ras-Pka pathways; Hsp12p 107579 HSP12 850532 HSP12 Saccharomyces cerevisiae Hsp12p NP_116640.1 107250 D 4932 CDS NP_116641.1 14318508 850534 complement(107846..109924) 1 NC_001138.4 Subunit of the INO80 chromatin remodeling complex; Ies1p 109924 IES1 850534 IES1 Saccharomyces cerevisiae Ies1p NP_116641.1 107846 R 4932 CDS NP_116643.1 14318509 850535 110641..111087 1 NC_001138.4 Yfl012wp; Putative protein of unknown function; transcribed during sporulation; null mutant exhibits increased resistance to rapamycin 111087 850535 YFL012W Saccharomyces cerevisiae Putative protein of unknown function; transcribed during sporulation; null mutant exhibits increased resistance to rapamycin NP_116643.1 110641 D 4932 CDS NP_116644.1 14318510 850536 112339..113979 1 NC_001138.4 Putative hexose transporter, expressed at low levels and expression is repressed by glucose; Hxt10p 113979 HXT10 850536 HXT10 Saccharomyces cerevisiae Hxt10p NP_116644.1 112339 D 4932 CDS NP_116645.1 14318511 850537 114984..115268 1 NC_001138.4 Protein required for the negative regulation by ammonia of Gap1p, which is a general amino acid permease; Aua1p 115268 AUA1 850537 AUA1 Saccharomyces cerevisiae Aua1p NP_116645.1 114984 D 4932 CDS NP_570898.1 18702303 850538 complement(115102..115737) 1 NC_001138.4 Wwm1p; WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes Gi phase growth arrest and clonal death that is suppressed by overexpression of MCA1 115737 WWM1 850538 WWM1 Saccharomyces cerevisiae WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes Gi phase growth arrest and clonal death that is suppressed by overexpression of MCA1 NP_570898.1 115102 R 4932 CDS NP_116585.1 14318513 850539 116139..118478 1 NC_001138.4 F-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p; Cdc4p 118478 CDC4 850539 CDC4 Saccharomyces cerevisiae Cdc4p NP_116585.1 116139 D 4932 CDS NP_116647.1 14318514 850540 119424..123101 1 NC_001138.4 Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure; Smc1p 123101 SMC1 850540 SMC1 Saccharomyces cerevisiae Smc1p NP_116647.1 119424 D 4932 CDS NP_116648.2 37362646 850541 123474..129905 1 NC_001138.4 Proteosome activator subunit; found in association with core particles, with and without the 19S regulatory particle; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200; Blm10p 129905 BLM10 850541 BLM10 Saccharomyces cerevisiae Blm10p NP_116648.2 123474 D 4932 CDS NP_116650.1 14318517 850543 130329..130976 1 NC_001138.4 Secretory vesicle-associated Rab GTPase essential for exocytosis; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane; Sec4p 130976 SEC4 850543 SEC4 Saccharomyces cerevisiae Sec4p NP_116650.1 130329 D 4932 CDS NP_116651.1 14318518 850544 131805..134291 1 NC_001138.4 Vtc2p; Vacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in protein localization and non-autophagic vacuolar fusion 134291 VTC2 850544 VTC2 Saccharomyces cerevisiae Vacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in protein localization and non-autophagic vacuolar fusion NP_116651.1 131805 D 4932 CDS NP_116652.1 14318519 850545 complement(134516..137152) 1 NC_001138.4 Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein; Msh4p 137152 MSH4 850545 MSH4 Saccharomyces cerevisiae Msh4p NP_116652.1 134516 R 4932 CDS NP_116653.1 14318520 850548 join(138199..139491,139493..143512) 1 NC_001138.4 Yfl002w-ap; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 143512 850548 YFL002W-A Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_116653.1 138199 D 4932 CDS NP_058157.1 7839169 850547 138199..139515 1 NC_001138.4 Yfl002w-bp; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 139515 850547 YFL002W-B Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_058157.1 138199 D 4932 CDS NP_116654.1 14318521 850549 complement(145109..146929) 1 NC_001138.4 Spb4p; Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients 146929 SPB4 850549 SPB4 Saccharomyces cerevisiae Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients NP_116654.1 145109 R 4932 CDS NP_116655.1 14318522 850550 147126..148454 1 NC_001138.4 Non-essential tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; Deg1p 148454 DEG1 850550 DEG1 Saccharomyces cerevisiae Deg1p NP_116655.1 147126 D 4932 CDS NP_116656.1 14318523 850551 149105..149719 1 NC_001138.4 Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particles; Loc1p 149719 LOC1 850551 LOC1 Saccharomyces cerevisiae Loc1p NP_116656.1 149105 D 4932 CDS NP_116657.1 14318524 850552 150011..152530 1 NC_001138.4 Nic96p; Component of the nuclear pore complex, required for nuclear pore formation; forms a subcomplex with Nsp1p, Nup57p, and Nup49p 152530 NIC96 850552 NIC96 Saccharomyces cerevisiae Component of the nuclear pore complex, required for nuclear pore formation; forms a subcomplex with Nsp1p, Nup57p, and Nup49p NP_116657.1 150011 D 4932 CDS NP_116658.1 14318525 850553 complement(152652..153119) 1 NC_001138.4 Ypi1p; Inhibitor of the type I protein phosphatase Glc7p, which is involved in regulation of a variety of metabolic processes; overproduction causes decreased cellular content of glycogen 153119 YPI1 850553 YPI1 Saccharomyces cerevisiae Inhibitor of the type I protein phosphatase Glc7p, which is involved in regulation of a variety of metabolic processes; overproduction causes decreased cellular content of glycogen NP_116658.1 152652 R 4932 CDS NP_116659.1 14318526 850554 153388..154308 1 NC_001138.4 Rpn11p; Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates 154308 RPN11 850554 RPN11 Saccharomyces cerevisiae Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates NP_116659.1 153388 D 4932 CDS NP_116660.1 14318527 850555 complement(154522..155868) 1 NC_001138.4 Sad1p; Conserved zinc-finger domain protein involved in pre-mRNA splicing, required for assembly of U4 snRNA into the U4/U6 particle 155868 SAD1 850555 SAD1 Saccharomyces cerevisiae Conserved zinc-finger domain protein involved in pre-mRNA splicing, required for assembly of U4 snRNA into the U4/U6 particle NP_116660.1 154522 R 4932 CDS NP_116661.1 14318528 850556 156139..157746 1 NC_001138.4 Yfr006wp; Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene 157746 850556 YFR006W Saccharomyces cerevisiae Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene NP_116661.1 156139 D 4932 CDS NP_116662.1 14318529 850558 159293..160354 1 NC_001138.4 Yfh7p; Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) 160354 YFH7 850558 YFH7 Saccharomyces cerevisiae Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) NP_116662.1 159293 D 4932 CDS NP_116663.1 14318530 850559 160529..161194 1 NC_001138.4 Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; Far7p 161194 FAR7 850559 FAR7 Saccharomyces cerevisiae Far7p NP_116663.1 160529 D 4932 CDS NP_116664.1 14318531 850561 162482..164740 1 NC_001138.4 Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA; Gcn20p 164740 GCN20 850561 GCN20 Saccharomyces cerevisiae Gcn20p NP_116664.1 162482 D 4932 CDS NP_116665.1 14318532 850562 165060..166559 1 NC_001138.4 Ubp6p; Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; deletion causes hypersensitivity to cycloheximide and other toxic compounds 166559 UBP6 850562 UBP6 Saccharomyces cerevisiae Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; deletion causes hypersensitivity to cycloheximide and other toxic compounds NP_116665.1 165060 D 4932 CDS NP_116666.1 14318533 850563 complement(166739..167251) 1 NC_001138.4 Putative protein of unknown function; non-tagged protein is detected in highly purified mitochondria; null mutant displays increased frequency of mitochondrial genome loss (petite formation) and reduced growth rate in minimal glycerol media; Aim13p 167251 AIM13 850563 AIM13 Saccharomyces cerevisiae Aim13p NP_116666.1 166739 R 4932 CDS NP_116667.1 14318534 850565 167881..168489 1 NC_001138.4 Yfr012wp; Putative protein of unknown function 168489 850565 YFR012W Saccharomyces cerevisiae Putative protein of unknown function NP_116667.1 167881 D 4932 CDS NP_076889.1 13129167 850566 169216..169302 1 NC_001138.4 Yfr012w-ap; Putative protein of unknown function; identified by homology 169302 850566 YFR012W-A Saccharomyces cerevisiae Putative protein of unknown function; identified by homology NP_076889.1 169216 D 4932 CDS NP_116668.1 14318535 850567 169914..172277 1 NC_001138.4 Member of a complex (Isw1a) with Isw1p that has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; has homology to Esc8p, which is involved in silencing; Ioc3p 172277 IOC3 850567 IOC3 Saccharomyces cerevisiae Ioc3p NP_116668.1 169914 D 4932 CDS NP_116669.1 14318536 850568 complement(172529..173869) 1 NC_001138.4 Cmk1p; Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk2p and mammalian Cam Kinase II 173869 CMK1 850568 CMK1 Saccharomyces cerevisiae Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk2p and mammalian Cam Kinase II NP_116669.1 172529 R 4932 CDS NP_116670.1 14318537 850569 complement(174257..176383) 1 NC_001138.4 Gsy1p; Glycogen synthase with similarity to Gsy2p, the more highly expressed yeast homolog; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase 176383 GSY1 850569 GSY1 Saccharomyces cerevisiae Glycogen synthase with similarity to Gsy2p, the more highly expressed yeast homolog; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase NP_116670.1 174257 R 4932 CDS NP_116671.1 14318538 850570 complement(177034..180735) 1 NC_001138.4 Yfr016cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene 180735 850570 YFR016C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene NP_116671.1 177034 R 4932 CDS NP_116672.1 14318539 850572 complement(182262..182849) 1 NC_001138.4 Yfr017cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YFR017C is not an essential gene 182849 850572 YFR017C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YFR017C is not an essential gene NP_116672.1 182262 R 4932 CDS NP_116673.1 14318540 850573 complement(183119..184210) 1 NC_001138.4 Yfr018cp; Putative protein of unknown function 184210 850573 YFR018C Saccharomyces cerevisiae Putative protein of unknown function NP_116673.1 183119 R 4932 CDS NP_116674.1 14318541 850574 184490..191326 1 NC_001138.4 Fab1p; 1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis 191326 FAB1 850574 FAB1 Saccharomyces cerevisiae 1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis NP_116674.1 184490 D 4932 CDS NP_444297.1 16740527 850577 194800..196302 1 NC_001138.4 Phosphoinositide binding protein required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein; Atg18p 196302 ATG18 850577 ATG18 Saccharomyces cerevisiae Atg18p NP_444297.1 194800 D 4932 CDS NP_116677.1 14318544 850578 196821..199022 1 NC_001138.4 Rog3p; Protein that binds to Rsp5p, which is a hect-type ubiquitin ligase, via its 2 PY motifs; has similarity to Rod1p; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant 199022 ROG3 850578 ROG3 Saccharomyces cerevisiae Protein that binds to Rsp5p, which is a hect-type ubiquitin ligase, via its 2 PY motifs; has similarity to Rod1p; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant NP_116677.1 196821 D 4932 CDS NP_116678.1 14318545 850579 199862..201697 1 NC_001138.4 Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation, similar to Mip6p; Pes4p 201697 PES4 850579 PES4 Saccharomyces cerevisiae Pes4p NP_116678.1 199862 D 4932 CDS NP_219497.1 15530184 850580 complement(join(201948..203256,203375..203421)) 1 NC_001138.4 Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; Lsb3p 203421 LSB3 850580 LSB3 Saccharomyces cerevisiae Lsb3p NP_219497.1 201948 R 4932 CDS NP_116681.1 14318548 850581 complement(203731..204738) 1 NC_001138.4 Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control; His2p 204738 HIS2 850581 HIS2 Saccharomyces cerevisiae His2p NP_116681.1 203731 R 4932 CDS NP_116682.1 14318549 850583 complement(205736..206245) 1 NC_001138.4 Yfr026cp; Putative protein of unknown function 206245 850583 YFR026C Saccharomyces cerevisiae Putative protein of unknown function NP_116682.1 205736 R 4932 CDS NP_116683.1 14318550 850584 207440..208285 1 NC_001138.4 Eco1p; Acetyltransferase required for the establishment of sister chromatid cohesion during DNA replication and in response to double-strand breaks; also required for postreplicative double-strand break repair 208285 ECO1 850584 ECO1 Saccharomyces cerevisiae Acetyltransferase required for the establishment of sister chromatid cohesion during DNA replication and in response to double-strand breaks; also required for postreplicative double-strand break repair NP_116683.1 207440 D 4932 CDS NP_116684.1 14318551 850585 complement(208401..210056) 1 NC_001138.4 Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit; Cdc14p 210056 CDC14 850585 CDC14 Saccharomyces cerevisiae Cdc14p NP_116684.1 208401 R 4932 CDS NP_116685.1 14318552 850587 210925..212961 1 NC_001138.4 Ptr3p; Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes 212961 PTR3 850587 PTR3 Saccharomyces cerevisiae Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes NP_116685.1 210925 D 4932 CDS NP_116686.1 14318553 850588 213300..216407 1 NC_001138.4 Subunit alpha of assimilatory sulfite reductase, which is responsible for the conversion of sulfite into sulfide; Met10p 216407 MET10 850588 MET10 Saccharomyces cerevisiae Met10p NP_116686.1 213300 D 4932 CDS NP_116687.1 14318554 850589 complement(216582..220094) 1 NC_001138.4 Smc2p; Component of the condensin complex, essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA, possibly in the cleft formed by the coiled-coil of the folded dimer 220094 SMC2 850589 SMC2 Saccharomyces cerevisiae Component of the condensin complex, essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA, possibly in the cleft formed by the coiled-coil of the folded dimer NP_116687.1 216582 R 4932 CDS NP_116688.1 14318555 850590 complement(join(220495..221255,221403..221406)) 1 NC_001138.4 Rpl2ap; Protein component of the large (60S) ribosomal subunit, identical to Rpl2Bp and has similarity to E. coli L2 and rat L8 ribosomal proteins 221406 RPL2A 850590 RPL2A Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, identical to Rpl2Bp and has similarity to E. coli L2 and rat L8 ribosomal proteins NP_116688.1 220495 R 4932 CDS NP_116689.1 14318556 850591 complement(222078..222947) 1 NC_001138.4 Yfr032cp; Putative protein of unknown function; transcribed during sporulation; YFR032C is not an essential gene 222947 850591 YFR032C Saccharomyces cerevisiae Putative protein of unknown function; transcribed during sporulation; YFR032C is not an essential gene NP_116689.1 222078 R 4932 CDS NP_116690.1 14318557 850592 complement(223246..223425) 1 NC_001138.4 Rpl29p; Protein component of the large (60S) ribosomal subunit, has similarity to rat L29 ribosomal protein; not essential for translation, but required for proper joining of the large and small ribosomal subunits and for normal translation rate 223425 RPL29 850592 RPL29 Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, has similarity to rat L29 ribosomal protein; not essential for translation, but required for proper joining of the large and small ribosomal subunits and for normal translation rate NP_116690.1 223246 R 4932 CDS NP_878072.1 33438790 1466402 complement(223698..223961) 1 NC_001138.4 Yfr032c-bp; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 223961 1466402 YFR032C-B Saccharomyces cerevisiae Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching NP_878072.1 223698 R 4932 CDS NP_116691.1 14318558 850593 complement(224314..224757) 1 NC_001138.4 Subunit 6 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; Qcr6p 224757 QCR6 850593 QCR6 Saccharomyces cerevisiae Qcr6p NP_116691.1 224314 R 4932 CDS NP_116692.1 14318559 850594 complement(225008..225946) 1 NC_001138.4 Pho4p; Basic helix-loop-helix (bHLH) transcription factor of the myc-family; binds cooperatively with Pho2p to the PHO5 promoter; function is regulated by phosphorylation at multiple sites and by phosphate availability 225946 PHO4 850594 PHO4 Saccharomyces cerevisiae Basic helix-loop-helix (bHLH) transcription factor of the myc-family; binds cooperatively with Pho2p to the PHO5 promoter; function is regulated by phosphorylation at multiple sites and by phosphate availability NP_116692.1 225008 R 4932 CDS NP_116693.1 14318560 850595 complement(226109..226453) 1 NC_001138.4 Yfr035cp; Putative protein of unknown function, deletion mutant exhibits synthetic phenotype with alpha-synuclein 226453 850595 YFR035C Saccharomyces cerevisiae Putative protein of unknown function, deletion mutant exhibits synthetic phenotype with alpha-synuclein NP_116693.1 226109 R 4932 CDS NP_116694.1 14318561 850597 226950..227324 1 NC_001138.4 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; Cdc26p 227324 CDC26 850597 CDC26 Saccharomyces cerevisiae Cdc26p NP_116694.1 226950 D 4932 CDS NP_116695.1 14318562 850598 complement(227500..229173) 1 NC_001138.4 Rsc8p; Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters 229173 RSC8 850598 RSC8 Saccharomyces cerevisiae Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters NP_116695.1 227500 R 4932 CDS NP_116696.2 42742173 850599 229367..231928 1 NC_001138.4 Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52 foci; Irc5p 231928 IRC5 850599 IRC5 Saccharomyces cerevisiae Irc5p NP_116696.2 229367 D 4932 CDS NP_116697.1 14318564 850600 complement(231999..233531) 1 NC_001138.4 Yfr039cp; Putative protein of unknown function; YFR039C is not an essential gene 233531 850600 YFR039C Saccharomyces cerevisiae Putative protein of unknown function; YFR039C is not an essential gene NP_116697.1 231999 R 4932 CDS NP_116698.2 37362647 850601 234229..237237 1 NC_001138.4 Sap155p; Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p 237237 SAP155 850601 SAP155 Saccharomyces cerevisiae Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p NP_116698.2 234229 D 4932 CDS NP_116699.1 14318566 850602 complement(237355..238242) 1 NC_001138.4 Type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response; Erj5p 238242 ERJ5 850602 ERJ5 Saccharomyces cerevisiae Erj5p NP_116699.1 237355 R 4932 CDS NP_116700.1 14318567 850603 238445..239047 1 NC_001138.4 Protein of unknown function required for cell viability; localizes to the endoplasmic reticulum membrane; Keg1p 239047 KEG1 850603 KEG1 Saccharomyces cerevisiae Keg1p NP_116700.1 238445 D 4932 CDS NP_116701.1 14318568 850604 complement(239101..239814) 1 NC_001138.4 hypothetical protein; null mutant displays increased levels of spontaneous Rad52 foci; Irc6p 239814 IRC6 850604 IRC6 Saccharomyces cerevisiae Irc6p NP_116701.1 239101 R 4932 CDS NP_116702.1 14318569 850605 complement(239979..241424) 1 NC_001138.4 Probable di- and tri-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p); Dug1p 241424 DUG1 850605 DUG1 Saccharomyces cerevisiae Dug1p NP_116702.1 239979 R 4932 CDS NP_116703.3 144228167 850606 join(241985..241996,242069..242986) 1 NC_001138.4 Yfr045wp; Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white 242986 850606 YFR045W Saccharomyces cerevisiae Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white NP_116703.3 241985 D 4932 CDS NP_116704.1 14318571 850607 complement(243061..244146) 1 NC_001138.4 Kinetochore protein of unknown function; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by both Clb5-Cdk1 and, to a lesser extent, Clb2-Cdk1.; Cnn1p 244146 CNN1 850607 CNN1 Saccharomyces cerevisiae Cnn1p NP_116704.1 243061 R 4932 CDS NP_602317.1 19705600 850608 complement(244266..245153) 1 NC_001138.4 Quinolinate phosphoribosyl transferase, required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway; Bna6p 245153 BNA6 850608 BNA6 Saccharomyces cerevisiae Bna6p NP_602317.1 244266 R 4932 CDS NP_683716.1 22532998 850609 246133..248121 1 NC_001138.4 Rmd8p; Cytosolic protein required for sporulation 248121 RMD8 850609 RMD8 Saccharomyces cerevisiae Cytosolic protein required for sporulation NP_683716.1 246133 D 4932 CDS NP_116707.1 14318574 850610 248510..248881 1 NC_001138.4 Ymr31p; Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36 248881 YMR31 850610 YMR31 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36 NP_116707.1 248510 D 4932 CDS NP_116708.1 14318575 850611 complement(249053..249853) 1 NC_001138.4 Pre4p; 20S proteasome beta-type subunit 249853 PRE4 850611 PRE4 Saccharomyces cerevisiae 20S proteasome beta-type subunit NP_116708.1 249053 R 4932 CDS NP_116709.1 14318576 850612 complement(250150..251790) 1 NC_001138.4 Ret2p; Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER 251790 RET2 850612 RET2 Saccharomyces cerevisiae Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER NP_116709.1 250150 R 4932 CDS NP_116710.1 14318577 850613 252492..253316 1 NC_001138.4 Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p; Rpn12p 253316 RPN12 850613 RPN12 Saccharomyces cerevisiae Rpn12p NP_116710.1 252492 D 4932 CDS NP_116711.1 14318578 850614 complement(253579..255036) 1 NC_001138.4 Hxk1p; Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p 255036 HXK1 850614 HXK1 Saccharomyces cerevisiae Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p NP_116711.1 253579 R 4932 CDS NP_116714.1 14318580 850616 264191..265213 1 NC_001138.4 Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52 foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner; Irc7p 265213 IRC7 850616 IRC7 Saccharomyces cerevisiae Irc7p NP_116714.1 264191 D 4932 CDS NP_116715.1 14318582 850618 269048..269503 1 NC_001138.4 Yfr057wp; Putative protein of unknown function 269503 850618 YFR057W Saccharomyces cerevisiae Putative protein of unknown function NP_116715.1 269048 D 4932 CDS NP_011251.1 6321174 852628 2790..3932 1 NC_001139.8 Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; Cos12p 3932 COS12 852628 COS12 Saccharomyces cerevisiae Cos12p NP_011251.1 2790 D 4932 CDS NP_011252.1 6321175 852629 5312..5839 1 NC_001139.8 Ygl262wp; Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene 5839 852629 YGL262W Saccharomyces cerevisiae Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene NP_011252.1 5312 D 4932 CDS NP_011253.1 6321176 852630 complement(6290..6652) 1 NC_001139.8 Putative protein of unknown function; mRNA expression appears to be regulated by SUT1 and UPC2; Pau11p 6652 PAU11 852630 PAU11 Saccharomyces cerevisiae Pau11p NP_011253.1 6290 R 4932 CDS NP_011254.1 6321177 852631 6860..7090 1 NC_001139.8 Ygl260wp; Putative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium 7090 852631 YGL260W Saccharomyces cerevisiae Putative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium NP_011254.1 6860 D 4932 CDS NP_011255.1 6321178 852632 8470..8967 1 NC_001139.8 Yps5p; Protein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p 8967 YPS5 852632 YPS5 Saccharomyces cerevisiae Protein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p NP_011255.1 8470 D 4932 CDS NP_076890.1 13129168 852633 9162..9395 1 NC_001139.8 Ygl258w-ap; Putative protein of unknown function 9395 852633 YGL258W-A Saccharomyces cerevisiae Putative protein of unknown function NP_076890.1 9162 D 4932 CDS NP_011256.1 6321179 852634 11110..11730 1 NC_001139.8 Vel1p; Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants 11730 VEL1 852634 VEL1 Saccharomyces cerevisiae Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants NP_011256.1 11110 D 4932 CDS NP_011257.1 6321180 852635 complement(12481..14157) 1 NC_001139.8 Mnt2p; Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans 14157 MNT2 852635 MNT2 Saccharomyces cerevisiae Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans NP_011257.1 12481 R 4932 CDS NP_011258.1 6321181 852636 14910..16307 1 NC_001139.8 Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency; Adh4p 16307 ADH4 852636 ADH4 Saccharomyces cerevisiae Adh4p NP_011258.1 14910 D 4932 CDS NP_011259.1 6321182 852637 20978..22108 1 NC_001139.8 Zrt1p; High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor 22108 ZRT1 852637 ZRT1 Saccharomyces cerevisiae High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor NP_011259.1 20978 D 4932 CDS NP_011260.1 6321183 852638 22304..23203 1 NC_001139.8 Transcription factor involved in sulfite metabolism, sole identified regulatory target is SSU1, overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers; Fzf1p 23203 FZF1 852638 FZF1 Saccharomyces cerevisiae Fzf1p NP_011260.1 22304 D 4932 CDS NP_011261.1 6321184 852639 23935..25395 1 NC_001139.8 Hxk2p; Hexokinase isoenzyme 2 that catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene 25395 HXK2 852639 HXK2 Saccharomyces cerevisiae Hexokinase isoenzyme 2 that catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene NP_011261.1 23935 D 4932 CDS NP_011262.1 6321185 852640 complement(25718..27484) 1 NC_001139.8 Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p; Rtg2p 27484 RTG2 852640 RTG2 Saccharomyces cerevisiae Rtg2p NP_011262.1 25718 R 4932 CDS NP_011263.2 9755332 852641 complement(join(27921..31426,31579..31636)) 1 NC_001139.8 Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity; Hfm1p 31636 HFM1 852641 HFM1 Saccharomyces cerevisiae Hfm1p NP_011263.2 27921 R 4932 CDS NP_011264.2 37362648 852642 31910..32635 1 NC_001139.8 Rmr1p; Putative protein of unknown function; deletion mutant results in reduced PIS1 expression and has growth defects on non-fermentable carbon sources and on minimal media; GFP-fusion protein localizes to both the cytoplasm and the nucleus 32635 RMR1 852642 RMR1 Saccharomyces cerevisiae Putative protein of unknown function; deletion mutant results in reduced PIS1 expression and has growth defects on non-fermentable carbon sources and on minimal media; GFP-fusion protein localizes to both the cytoplasm and the nucleus NP_011264.2 31910 D 4932 CDS NP_011265.1 6321188 852643 33098..35212 1 NC_001139.8 Zip2p; Meiosis-specific protein involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis 35212 ZIP2 852643 ZIP2 Saccharomyces cerevisiae Meiosis-specific protein involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis NP_011265.1 33098 D 4932 CDS NP_011266.1 6321189 852644 35653..36762 1 NC_001139.8 Pde1p; Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation 36762 PDE1 852644 PDE1 Saccharomyces cerevisiae Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation NP_011266.1 35653 D 4932 CDS NP_011267.1 6321190 852645 36933..37526 1 NC_001139.8 Essential nuclear envelope integral membrane protein required for nuclear transport; depletion alters nucleoporin distribution and nuclear envelope morphology, suggesting a role in the spatial organization of nuclear pores; Brr6p 37526 BRR6 852645 BRR6 Saccharomyces cerevisiae Brr6p NP_011267.1 36933 D 4932 CDS NP_011268.1 6321191 852646 complement(37617..38780) 1 NC_001139.8 Rai1p; Nuclear protein that binds to and stabilizes the exoribonuclease Rat1p, required for pre-rRNA processing 38780 RAI1 852646 RAI1 Saccharomyces cerevisiae Nuclear protein that binds to and stabilizes the exoribonuclease Rat1p, required for pre-rRNA processing NP_011268.1 37617 R 4932 CDS NP_011269.2 37362649 852606 39023..41149 1 NC_001139.8 Gus1p; Glutamyl-tRNA synthetase (GluRS), forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm 41149 GUS1 852606 GUS1 Saccharomyces cerevisiae Glutamyl-tRNA synthetase (GluRS), forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm NP_011269.2 39023 D 4932 CDS NP_011270.1 6321193 852607 41498..43174 1 NC_001139.8 Subunit of the RNA polymerase II-associated Paf1 complex; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in telomere maintenance; Rtf1p 43174 RTF1 852607 RTF1 Saccharomyces cerevisiae Rtf1p NP_011270.1 41498 D 4932 CDS NP_011271.1 6321194 852608 43307..44509 1 NC_001139.8 tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala; Tad1p 44509 TAD1 852608 TAD1 Saccharomyces cerevisiae Tad1p NP_011271.1 43307 D 4932 CDS NP_011272.1 6321195 852609 complement(44652..45197) 1 NC_001139.8 Ygl242cp; Putative protein of unknown function; deletion mutant is viable 45197 852609 YGL242C Saccharomyces cerevisiae Putative protein of unknown function; deletion mutant is viable NP_011272.1 44652 R 4932 CDS NP_011273.1 6321196 852610 45445..48459 1 NC_001139.8 Karyopherin, responsible for nuclear import of Spt15p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear; Kap114p 48459 KAP114 852610 KAP114 Saccharomyces cerevisiae Kap114p NP_011273.1 45445 D 4932 CDS NP_011274.2 37362650 852611 48613..49365 1 NC_001139.8 Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis; Doc1p 49365 DOC1 852611 DOC1 Saccharomyces cerevisiae Doc1p NP_011274.2 48613 D 4932 CDS NP_011276.1 6321198 852612 49552..52434 1 NC_001139.8 Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation; Cse1p 52434 CSE1 852612 CSE1 Saccharomyces cerevisiae Cse1p NP_011276.1 49552 D 4932 CDS NP_011277.1 6321200 852614 complement(52731..53528) 1 NC_001139.8 Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding; Hap2p 53528 HAP2 852614 HAP2 Saccharomyces cerevisiae Hap2p NP_011277.1 52731 R 4932 CDS NP_011278.2 50593214 852616 complement(53787..55796) 1 NC_001139.8 Mto1p; Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants 55796 MTO1 852616 MTO1 Saccharomyces cerevisiae Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants NP_011278.2 53787 R 4932 CDS NP_011279.1 6321201 852615 55279..55815 1 NC_001139.8 Ygl235wp; Putative protein of unknown function; potential Cdc28p substrate 55815 852615 YGL235W Saccharomyces cerevisiae Putative protein of unknown function; potential Cdc28p substrate NP_011279.1 55279 D 4932 CDS NP_011280.1 6321203 852617 56482..58890 1 NC_001139.8 Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities; Ade5,7p 58890 ADE5,7 852617 ADE5,7 Saccharomyces cerevisiae Ade5,7p NP_011280.1 56482 D 4932 CDS NP_011281.1 6321204 852618 59122..61854 1 NC_001139.8 Sec15p; Essential 113kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which mediates polarized targeting of vesicles to active sites of exocytosis; Sec15p associates with Sec4p and vesicles 61854 SEC15 852618 SEC15 Saccharomyces cerevisiae Essential 113kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which mediates polarized targeting of vesicles to active sites of exocytosis; Sec15p associates with Sec4p and vesicles NP_011281.1 59122 D 4932 CDS NP_011282.1 6321205 852619 join(62075..62131,62190..63002) 1 NC_001139.8 Tan1p; Putative tRNA acetyltransferase, RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA 63002 TAN1 852619 TAN1 Saccharomyces cerevisiae Putative tRNA acetyltransferase, RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA NP_011282.1 62075 D 4932 CDS NP_011283.1 6321206 852620 complement(63048..63620) 1 NC_001139.8 Ygl231cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum 63620 852620 YGL231C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum NP_011283.1 63048 R 4932 CDS NP_011284.1 6321207 852621 complement(63772..64215) 1 NC_001139.8 Ygl230cp; Putative protein of unknown function; non-essential gene 64215 852621 YGL230C Saccharomyces cerevisiae Putative protein of unknown function; non-essential gene NP_011284.1 63772 R 4932 CDS NP_011285.1 6321208 852622 complement(64503..66959) 1 NC_001139.8 Sap4p; Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p 66959 SAP4 852622 SAP4 Saccharomyces cerevisiae Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p NP_011285.1 64503 R 4932 CDS NP_011286.1 6321209 852623 67598..69331 1 NC_001139.8 She10p; Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function; overexpression causes growth arrest 69331 SHE10 852623 SHE10 Saccharomyces cerevisiae Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function; overexpression causes growth arrest NP_011286.1 67598 D 4932 CDS NP_011287.1 6321210 852624 69671..72547 1 NC_001139.8 Vid30p; Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); shifts the balance of nitrogen metabolism toward the production of glutamate; localized to the nucleus and the cytoplasm 72547 VID30 852624 VID30 Saccharomyces cerevisiae Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); shifts the balance of nitrogen metabolism toward the production of glutamate; localized to the nucleus and the cytoplasm NP_011287.1 69671 D 4932 CDS NP_011288.1 6321211 852625 complement(join(72748..72987,73137..73157)) 1 NC_001139.8 Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost5p 73157 OST5 852625 OST5 Saccharomyces cerevisiae Ost5p NP_011288.1 72748 R 4932 CDS NP_011289.1 6321212 852626 73339..73710 1 NC_001139.8 Ygl226wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion 73710 852626 YGL226W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion NP_011289.1 73339 D 4932 CDS NP_011290.1 6321213 852647 76893..77906 1 NC_001139.8 Vrg4p; Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi 77906 VRG4 852647 VRG4 Saccharomyces cerevisiae Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi NP_011290.1 76893 D 4932 CDS NP_011291.1 6321214 852648 complement(78014..78856) 1 NC_001139.8 Sdt1p; Pyrimidine nucleotidase; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives 78856 SDT1 852648 SDT1 Saccharomyces cerevisiae Pyrimidine nucleotidase; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives NP_011291.1 78014 R 4932 CDS NP_011292.1 6321215 852649 complement(79111..80364) 1 NC_001139.8 Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; Cog1p 80364 COG1 852649 COG1 Saccharomyces cerevisiae Cog1p NP_011292.1 79111 R 4932 CDS NP_011293.1 6321216 852650 complement(80658..81185) 1 NC_001139.8 RNA-binding protein, activates mRNA decapping directly by binding to the mRNA substrate and enhancing the activity of the decapping proteins Dcp1p and Dcp2p; Edc1p 81185 EDC1 852650 EDC1 Saccharomyces cerevisiae Edc1p NP_011293.1 80658 R 4932 CDS NP_011294.1 6321217 852651 complement(81425..82291) 1 NC_001139.8 Protein of unknown function, similar to Listeria monocytogenes major sigma factor (rpoD gene product); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Nif3p 82291 NIF3 852651 NIF3 Saccharomyces cerevisiae Nif3p NP_011294.1 81425 R 4932 CDS NP_011295.1 6321218 852652 82373..82735 1 NC_001139.8 Putative protein of unknown function; (GFP)-fusion protein localizes to the cytoplasm and the nucleus; null mutant displays decreased mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media; Aim15p 82735 AIM15 852652 AIM15 Saccharomyces cerevisiae Aim15p NP_011295.1 82373 D 4932 CDS NP_011296.1 6321220 852654 complement(82877..84256) 1 NC_001139.8 Mitochondrial outer membrane protein, required for normal mitochondrial morphology and inheritance; localizes to dots on the mitochondrial surface near mtDNA nucleoids; interacts genetically with MDM31 and MDM32; Mdm34p 84256 MDM34 852654 MDM34 Saccharomyces cerevisiae Mdm34p NP_011296.1 82877 R 4932 CDS NP_011299.1 6321221 852655 84884..87301 1 NC_001139.8 Kip3p; Kinesin-related motor protein involved in mitotic spindle positioning 87301 KIP3 852655 KIP3 Saccharomyces cerevisiae Kinesin-related motor protein involved in mitotic spindle positioning NP_011299.1 84884 D 4932 CDS NP_011300.1 6321223 852657 87980..89338 1 NC_001139.8 Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2; Clg1p 89338 CLG1 852657 CLG1 Saccharomyces cerevisiae Clg1p NP_011300.1 87980 D 4932 CDS NP_011302.1 6321225 852659 complement(90058..91251) 1 NC_001139.8 Ski8p; Protein involved in exosome mediated 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs as well as double-strand break formation during meiotic recombination; required for repressing propagation of dsRNA viruses 91251 SKI8 852659 SKI8 Saccharomyces cerevisiae Protein involved in exosome mediated 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs as well as double-strand break formation during meiotic recombination; required for repressing propagation of dsRNA viruses NP_011302.1 90058 R 4932 CDS NP_011303.1 6321226 852660 91436..92386 1 NC_001139.8 Vam7p; Component of the vacuole SNARE complex involved in vacuolar morphogenesis; SNAP-25 homolog; functions with a syntaxin homolog Vam3p in vacuolar protein trafficking 92386 VAM7 852660 VAM7 Saccharomyces cerevisiae Component of the vacuole SNARE complex involved in vacuolar morphogenesis; SNAP-25 homolog; functions with a syntaxin homolog Vam3p in vacuolar protein trafficking NP_011303.1 91436 D 4932 CDS NP_011304.2 50593215 852661 92516..93595 1 NC_001139.8 Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae; Ncs6p 93595 NCS6 852661 NCS6 Saccharomyces cerevisiae Ncs6p NP_011304.2 92516 D 4932 CDS NP_011305.1 6321228 852662 93797..94465 1 NC_001139.8 Ypt32p; GTPase of the Ypt/Rab family, very similar to Ypt31p; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi 94465 YPT32 852662 YPT32 Saccharomyces cerevisiae GTPase of the Ypt/Rab family, very similar to Ypt31p; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi NP_011305.1 93797 D 4932 CDS NP_011306.1 6321229 852663 95862..97010 1 NC_001139.8 Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter; Mig2p 97010 MIG2 852663 MIG2 Saccharomyces cerevisiae Mig2p NP_011306.1 95862 D 4932 CDS NP_011307.1 6321230 852664 97342..98589 1 NC_001139.8 Sip2p; One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane 98589 SIP2 852664 SIP2 Saccharomyces cerevisiae One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane NP_011307.1 97342 D 4932 CDS NP_011308.1 6321231 852665 98973..102080 1 NC_001139.8 Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), facilitates RNA Polymerase II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structure; Spt16p 102080 SPT16 852665 SPT16 Saccharomyces cerevisiae Spt16p NP_011308.1 98973 D 4932 CDS NP_011309.1 6321232 852666 complement(102547..107508) 1 NC_001139.8 Clathrin heavy chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; two heavy chains form the clathrin triskelion structural component; the light chain (CLC1) is thought to regulate function; Chc1p 107508 CHC1 852666 CHC1 Saccharomyces cerevisiae Chc1p NP_011309.1 102547 R 4932 CDS NP_011310.1 6321233 852667 108162..110408 1 NC_001139.8 Pox1p; Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix 110408 POX1 852667 POX1 Saccharomyces cerevisiae Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix NP_011310.1 108162 D 4932 CDS NP_011312.1 6321235 852670 complement(112479..114668) 1 NC_001139.8 Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins; Kex1p 114668 KEX1 852670 KEX1 Saccharomyces cerevisiae Kex1p NP_011312.1 112479 R 4932 CDS NP_011313.1 6321236 852672 116063..117565 1 NC_001139.8 Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis; Aro8p 117565 ARO8 852672 ARO8 Saccharomyces cerevisiae Aro8p NP_011313.1 116063 D 4932 CDS NP_011314.2 41629691 852673 complement(117858..120911) 1 NC_001139.8 Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; Mcm6p 120911 MCM6 852673 MCM6 Saccharomyces cerevisiae Mcm6p NP_011314.2 117858 R 4932 CDS NP_011315.1 6321238 852675 complement(122699..123310) 1 NC_001139.8 Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport; Emp24p 123310 EMP24 852675 EMP24 Saccharomyces cerevisiae Emp24p NP_011315.1 122699 R 4932 CDS NP_011317.2 41629692 852676 123596..124303 1 NC_001139.8 Yip4p; Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport 124303 YIP4 852676 YIP4 Saccharomyces cerevisiae Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport NP_011317.2 123596 D 4932 CDS NP_011318.1 6321241 852678 124703..129166 1 NC_001139.8 Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions; Mds3p 129166 MDS3 852678 MDS3 Saccharomyces cerevisiae Mds3p NP_011318.1 124703 D 4932 CDS NP_011319.2 50593216 852679 129888..131174 1 NC_001139.8 Dsd1p; D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia; specifc for D-serine, unlike the bacterial enzyme which recognizes both D-serine and L-serine as substrates 131174 DSD1 852679 DSD1 Saccharomyces cerevisiae D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia; specifc for D-serine, unlike the bacterial enzyme which recognizes both D-serine and L-serine as substrates NP_011319.2 129888 D 4932 CDS NP_011320.1 6321243 852680 131531..139549 1 NC_001139.8 Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn20p; proposed to stimulate Gcn2p activation by an uncharged tRNA; Gcn1p 139549 GCN1 852680 GCN1 Saccharomyces cerevisiae Gcn1p NP_011320.1 131531 D 4932 CDS NP_001032578.1 82795250 3799973 complement(139725..139967) 1 NC_001139.8 Ygl194c-ap; Putative protein of unknown function, identified based on comparisons of the genome sequences of six Saccharomyces species 139967 3799973 YGL194C-A Saccharomyces cerevisiae Putative protein of unknown function, identified based on comparisons of the genome sequences of six Saccharomyces species NP_001032578.1 139725 R 4932 CDS NP_011321.1 6321244 852681 complement(140374..141732) 1 NC_001139.8 Hos2p; Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity 141732 HOS2 852681 HOS2 Saccharomyces cerevisiae Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity NP_011321.1 140374 R 4932 CDS NP_011322.1 6321245 852682 complement(141922..142233) 1 NC_001139.8 Ygl193cp; Haploid-specific gene repressed by a1-alpha2, turned off in sir3 null strains, absence enhances the sensitivity of rad52-327 cells to campothecin almost 100-fold 142233 852682 YGL193C Saccharomyces cerevisiae Haploid-specific gene repressed by a1-alpha2, turned off in sir3 null strains, absence enhances the sensitivity of rad52-327 cells to campothecin almost 100-fold NP_011322.1 141922 R 4932 CDS NP_011323.1 6321246 852683 142252..144054 1 NC_001139.8 Probable mRNA N6-adenosine methyltransferase that is required for IME1 transcript accumulation and for sporulation; expression is induced in starved MATa/MAT alpha diploid cells; Ime4p 144054 IME4 852683 IME4 Saccharomyces cerevisiae Ime4p NP_011323.1 142252 D 4932 CDS NP_011324.1 6321247 852684 144814..145203 1 NC_001139.8 Subunit VIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; Cox13p 145203 COX13 852684 COX13 Saccharomyces cerevisiae Cox13p NP_011324.1 144814 D 4932 CDS NP_011325.1 6321248 852685 complement(145815..147395) 1 NC_001139.8 Non-essential regulatory subunit B of protein phosphatase 2A, which has multiple roles in mitosis and protein biosynthesis; involved in regulation of mitotic exit; found in the nucleus of most cells, also at the bud neck and at the bud tip; Cdc55p 147395 CDC55 852685 CDC55 Saccharomyces cerevisiae Cdc55p NP_011325.1 145815 R 4932 CDS NP_011326.1 6321249 852686 complement(148235..148594) 1 NC_001139.8 Rps26ap; Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Bp and has similarity to rat S26 ribosomal protein 148594 RPS26A 852686 RPS26A Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Bp and has similarity to rat S26 ribosomal protein NP_011326.1 148235 R 4932 CDS NP_878073.1 33438791 1466453 complement(148830..148970) 1 NC_001139.8 Ygl188c-ap; Putative protein of unknown function 148970 1466453 YGL188C-A Saccharomyces cerevisiae Putative protein of unknown function NP_878073.1 148830 R 4932 CDS NP_011328.1 6321251 852688 complement(149710..150177) 1 NC_001139.8 Subunit IV of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; N-terminal 25 residues of precursor are cleaved during mitochondrial import; phosphorylated; Cox4p 150177 COX4 852688 COX4 Saccharomyces cerevisiae Cox4p NP_011328.1 149710 R 4932 CDS NP_011329.1 6321252 852689 complement(151043..152782) 1 NC_001139.8 Tpn1p; Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p 152782 TPN1 852689 TPN1 Saccharomyces cerevisiae Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p NP_011329.1 151043 R 4932 CDS NP_011330.1 6321253 852690 complement(153173..154312) 1 NC_001139.8 Ygl185cp; Putative protein with sequence similarity to hydroxyacid dehydrogenases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 154312 852690 YGL185C Saccharomyces cerevisiae Putative protein with sequence similarity to hydroxyacid dehydrogenases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm NP_011330.1 153173 R 4932 CDS NP_011331.1 6321254 852691 complement(154621..156018) 1 NC_001139.8 Str3p; Cystathionine beta-lyase, converts cystathionine into homocysteine 156018 STR3 852691 STR3 Saccharomyces cerevisiae Cystathionine beta-lyase, converts cystathionine into homocysteine NP_011331.1 154621 R 4932 CDS NP_011332.2 27808704 852692 complement(join(156549..157205,157289..157291)) 1 NC_001139.8 Protein required for recombination and meiotic nuclear division; forms a complex with Hop2p, which is involved in chromosome pairing and repair of meiotic double-strand breaks; Mnd1p 157291 MND1 852692 MND1 Saccharomyces cerevisiae Mnd1p NP_011332.2 156549 R 4932 CDS NP_011334.1 6321257 852694 157912..159102 1 NC_001139.8 Protein containing a zinc-finger in the N-terminus and a long Gln-rich region in the C-terminus; regulates ultradian rhythm, cell size, cell cycle, lifespan, sporulation, heat tolerance, and multidrug transport; Gts1p 159102 GTS1 852694 GTS1 Saccharomyces cerevisiae Gts1p NP_011334.1 157912 D 4932 CDS NP_011335.1 6321258 852695 160071..162764 1 NC_001139.8 Protein serine/threonine kinase, required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for pre-autophagosome formation; forms a complex with Atg13p and Atg17p; Atg1p 162764 ATG1 852695 ATG1 Saccharomyces cerevisiae Atg1p NP_011335.1 160071 D 4932 CDS NP_011336.1 6321259 852696 complement(163415..165097) 1 NC_001139.8 Tos3p; Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome 165097 TOS3 852696 TOS3 Saccharomyces cerevisiae Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome NP_011336.1 163415 R 4932 CDS NP_011337.1 6321260 852697 join(167358..167360,168001..170577) 1 NC_001139.8 Mpt5p; Member of the Puf family of RNA-binding proteins; binds to mRNAs encoding chromatin modifiers and spindle pole body components; involved in longevity, maintenance of cell wall integrity, and sensitivity to and recovery from pheromone arrest 170577 MPT5 852697 MPT5 Saccharomyces cerevisiae Member of the Puf family of RNA-binding proteins; binds to mRNAs encoding chromatin modifiers and spindle pole body components; involved in longevity, maintenance of cell wall integrity, and sensitivity to and recovery from pheromone arrest NP_011337.1 167358 D 4932 CDS NP_011339.1 6321262 852699 complement(171421..173085) 1 NC_001139.8 Ygl176cp; Putative protein of unknown function; deletion mutant is viable and has no detectable phenotype 173085 852699 YGL176C Saccharomyces cerevisiae Putative protein of unknown function; deletion mutant is viable and has no detectable phenotype NP_011339.1 171421 R 4932 CDS NP_011340.1 6321263 852700 complement(173291..174328) 1 NC_001139.8 Sae2p; Protein with a role in accurate meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents 174328 SAE2 852700 SAE2 Saccharomyces cerevisiae Protein with a role in accurate meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents NP_011340.1 173291 R 4932 CDS NP_011341.1 6321264 852701 174551..175351 1 NC_001139.8 Subunit of the RES complex, which is required for nuclear pre-mRNA retention and splicing; involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern; Bud13p 175351 BUD13 852701 BUD13 Saccharomyces cerevisiae Bud13p NP_011341.1 174551 D 4932 CDS NP_011342.1 6321265 852702 complement(175533..180119) 1 NC_001139.8 Kem1p; Evolutionarily-conserved 5'-3' exonuclease component of cytoplasmic processing (P) bodies involved in mRNA decay; plays a role in microtubule-mediated processes, filamentous growth, ribosomal RNA maturation, and telomere maintenance 180119 KEM1 852702 KEM1 Saccharomyces cerevisiae Evolutionarily-conserved 5'-3' exonuclease component of cytoplasmic processing (P) bodies involved in mRNA decay; plays a role in microtubule-mediated processes, filamentous growth, ribosomal RNA maturation, and telomere maintenance NP_011342.1 175533 R 4932 CDS NP_011343.1 6321266 852703 180706..182124 1 NC_001139.8 Subunit of the Nsp1p-Nup57p-Nup49p-Nic96p subcomplex of the nuclear pore complex (NPC), required for nuclear export of ribosomes; Nup49p 182124 NUP49 852703 NUP49 Saccharomyces cerevisiae Nup49p NP_011343.1 180706 D 4932 CDS NP_011344.1 6321267 852704 182396..184090 1 NC_001139.8 Rok1p; ATP-dependent RNA helicase of the DEAD box family; required for 18S rRNA synthesis 184090 ROK1 852704 ROK1 Saccharomyces cerevisiae ATP-dependent RNA helicase of the DEAD box family; required for 18S rRNA synthesis NP_011344.1 182396 D 4932 CDS NP_011345.1 6321268 852705 complement(184159..185400) 1 NC_001139.8 Spo74p; Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation 185400 SPO74 852705 SPO74 Saccharomyces cerevisiae Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation NP_011345.1 184159 R 4932 CDS NP_011346.1 6321269 852707 186065..187345 1 NC_001139.8 Sua5p; Protein required for respiratory growth; null mutation suppresses the Cyc1p translation defect caused by the presence of an aberrant ATG codon upstream of the correct start 187345 SUA5 852707 SUA5 Saccharomyces cerevisiae Protein required for respiratory growth; null mutation suppresses the Cyc1p translation defect caused by the presence of an aberrant ATG codon upstream of the correct start NP_011346.1 186065 D 4932 CDS NP_011347.1 6321270 852708 187470..187802 1 NC_001139.8 Protein required for hydroxyurea resistance; has possible roles in DNA replication and maintenance of proper telomere length; Hur1p 187802 HUR1 852708 HUR1 Saccharomyces cerevisiae Hur1p NP_011347.1 187470 D 4932 CDS NP_011348.1 6321271 852709 complement(187622..190474) 1 NC_001139.8 Pmr1p; High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease 190474 PMR1 852709 PMR1 Saccharomyces cerevisiae High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease NP_011348.1 187622 R 4932 CDS NP_011349.1 6321272 852710 191135..191812 1 NC_001139.8 Cup2p; Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations 191812 CUP2 852710 CUP2 Saccharomyces cerevisiae Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations NP_011349.1 191135 D 4932 CDS NP_011351.1 6321274 852712 complement(191984..193306) 1 NC_001139.8 Yrb30p; RanGTP-binding protein, inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes 193306 YRB30 852712 YRB30 Saccharomyces cerevisiae RanGTP-binding protein, inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes NP_011351.1 191984 R 4932 CDS NP_011352.1 6321275 852713 complement(193713..196409) 1 NC_001139.8 Rad54p; DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family 196409 RAD54 852713 RAD54 Saccharomyces cerevisiae DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family NP_011352.1 193713 R 4932 CDS NP_011353.1 6321276 852714 198144..199043 1 NC_001139.8 Transcription factor of the Zn[II]2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression; Sut1p 199043 SUT1 852714 SUT1 Saccharomyces cerevisiae Sut1p NP_011353.1 198144 D 4932 CDS NP_011354.1 6321277 852715 complement(199216..200148) 1 NC_001139.8 Yip5p; Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport 200148 YIP5 852715 YIP5 Saccharomyces cerevisiae Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport NP_011354.1 199216 R 4932 CDS NP_011355.1 6321278 852716 200567..202279 1 NC_001139.8 Putative protein of unknown function; similar to iron/copper reductases (FRE1-8), possibly involved in iron homeostasis; may interact with ribosomes, null mutant displays increased frequency of mitochondrial genome loss (petite formation); Aim14p 202279 AIM14 852716 AIM14 Saccharomyces cerevisiae Aim14p NP_011355.1 200567 D 4932 CDS NP_011356.1 6321279 852717 202727..203839 1 NC_001139.8 Ygl159wp; Putative protein of unknown function; deletion mutant has no detectable phenotype 203839 852717 YGL159W Saccharomyces cerevisiae Putative protein of unknown function; deletion mutant has no detectable phenotype NP_011356.1 202727 D 4932 CDS NP_011357.1 6321280 852719 207038..208576 1 NC_001139.8 Rck1p; Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations 208576 RCK1 852719 RCK1 Saccharomyces cerevisiae Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations NP_011357.1 207038 D 4932 CDS NP_011358.1 6321281 852720 209011..210054 1 NC_001139.8 Ygl157wp; Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol) 210054 852720 YGL157W Saccharomyces cerevisiae Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol) NP_011358.1 209011 D 4932 CDS NP_011359.1 6321282 852721 210421..213672 1 NC_001139.8 Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway; Ams1p 213672 AMS1 852721 AMS1 Saccharomyces cerevisiae Ams1p NP_011359.1 210421 D 4932 CDS NP_011360.1 6321283 852722 214086..215216 1 NC_001139.8 Cdc43p; Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis 215216 CDC43 852722 CDC43 Saccharomyces cerevisiae Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis NP_011360.1 214086 D 4932 CDS NP_011361.1 6321284 852723 complement(215283..216101) 1 NC_001139.8 Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine; Lys5p 216101 LYS5 852723 LYS5 Saccharomyces cerevisiae Lys5p NP_011361.1 215283 R 4932 CDS NP_011362.1 6321285 852724 216278..217303 1 NC_001139.8 Pex14p; Peroxisomal membrane peroxin that is a central component of the peroxisomal protein import machinery; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p), peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p 217303 PEX14 852724 PEX14 Saccharomyces cerevisiae Peroxisomal membrane peroxin that is a central component of the peroxisomal protein import machinery; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p), peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p NP_011362.1 216278 D 4932 CDS NP_011364.1 6321287 852726 217529..220927 1 NC_001139.8 Nut1p; Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription 220927 NUT1 852726 NUT1 Saccharomyces cerevisiae Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription NP_011364.1 217529 D 4932 CDS NP_011365.1 6321289 852728 complement(221109..225578) 1 NC_001139.8 Ino80p; ATPase that forms a large complex, containing actin and several actin-related proteins, that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; shows similarity to the Snf2p family of ATPases 225578 INO80 852728 INO80 Saccharomyces cerevisiae ATPase that forms a large complex, containing actin and several actin-related proteins, that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; shows similarity to the Snf2p family of ATPases NP_011365.1 221109 R 4932 CDS NP_011367.1 6321290 852729 226404..227534 1 NC_001139.8 Bifunctional chorismate synthase and flavin reductase, catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; Aro2p 227534 ARO2 852729 ARO2 Saccharomyces cerevisiae Aro2p NP_011367.1 226404 D 4932 CDS NP_011368.1 6321291 852730 complement(227759..228334) 1 NC_001139.8 Rpl9ap; Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins 228334 RPL9A 852730 RPL9A Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins NP_011368.1 227759 R 4932 CDS NP_011369.1 6321292 852731 complement(228756..229691) 1 NC_001139.8 Ygl146cp; Putative protein of unknown function, contains two putative transmembrane spans, shows no significant homology to any other known protein sequence, YGL146C is not an essential gene 229691 852731 YGL146C Saccharomyces cerevisiae Putative protein of unknown function, contains two putative transmembrane spans, shows no significant homology to any other known protein sequence, YGL146C is not an essential gene NP_011369.1 228756 R 4932 CDS NP_116577.1 14318435 852732 230248..232353 1 NC_001139.8 Tip20p; Peripheral membrane protein required for fusion of COPI vesicles with the ER, prohibits back-fusion of COPII vesicles with the ER, may act as a sensor for vesicles at the ER membrane; interacts with Sec20p 232353 TIP20 852732 TIP20 Saccharomyces cerevisiae Peripheral membrane protein required for fusion of COPI vesicles with the ER, prohibits back-fusion of COPII vesicles with the ER, may act as a sensor for vesicles at the ER membrane; interacts with Sec20p NP_116577.1 230248 D 4932 CDS NP_011371.1 6321294 852733 complement(232455..234512) 1 NC_001139.8 Rog1p; Protein with putative serine active lipase domain 234512 ROG1 852733 ROG1 Saccharomyces cerevisiae Protein with putative serine active lipase domain NP_011371.1 232455 R 4932 CDS NP_011372.1 6321295 852734 complement(234722..235963) 1 NC_001139.8 Mrf1p; Mitochondrial translation release factor, involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability 235963 MRF1 852734 MRF1 Saccharomyces cerevisiae Mitochondrial translation release factor, involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability NP_011372.1 234722 R 4932 CDS NP_011373.1 6321296 852735 complement(236274..238124) 1 NC_001139.8 Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the GPI core structure; human PIG-Bp is a functional homolog; Gpi10p 238124 GPI10 852735 GPI10 Saccharomyces cerevisiae Gpi10p NP_011373.1 236274 R 4932 CDS NP_011374.1 6321297 852736 238358..241090 1 NC_001139.8 Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability; Hul5p 241090 HUL5 852736 HUL5 Saccharomyces cerevisiae Hul5p NP_011374.1 238358 D 4932 CDS NP_011375.1 6321298 852737 complement(241358..245017) 1 NC_001139.8 Ygl140cp; Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains 245017 852737 YGL140C Saccharomyces cerevisiae Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains NP_011375.1 241358 R 4932 CDS NP_011376.1 6321299 852738 245721..248129 1 NC_001139.8 Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER; Flc3p 248129 FLC3 852738 FLC3 Saccharomyces cerevisiae Flc3p NP_011376.1 245721 D 4932 CDS NP_011377.1 6321300 852739 complement(248499..249536) 1 NC_001139.8 Ygl138cp; Putative protein of unknown function; has no significant sequence similarity to any known protein 249536 852739 YGL138C Saccharomyces cerevisiae Putative protein of unknown function; has no significant sequence similarity to any known protein NP_011377.1 248499 R 4932 CDS NP_011378.1 6321301 852740 join(249874..249891,250092..252743) 1 NC_001139.8 Sec27p; Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP 252743 SEC27 852740 SEC27 Saccharomyces cerevisiae Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP NP_011378.1 249874 D 4932 CDS NP_011379.1 6321302 852741 complement(252902..253864) 1 NC_001139.8 Mrm2p; Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ 253864 MRM2 852741 MRM2 Saccharomyces cerevisiae Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ NP_011379.1 252902 R 4932 CDS NP_011380.1 6321303 852742 254646..255299 1 NC_001139.8 Rpl1bp; N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Ap and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal 255299 RPL1B 852742 RPL1B Saccharomyces cerevisiae N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Ap and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal NP_011380.1 254646 D 4932 CDS NP_011381.1 6321304 852743 255668..256969 1 NC_001139.8 Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate; Pcl10p 256969 PCL10 852743 PCL10 Saccharomyces cerevisiae Pcl10p NP_011381.1 255668 D 4932 CDS NP_011382.1 6321305 852744 257712..261506 1 NC_001139.8 Itc1p; Component of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1 261506 ITC1 852744 ITC1 Saccharomyces cerevisiae Component of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1 NP_011382.1 257712 D 4932 CDS NP_011384.1 6321307 852746 complement(261653..265864) 1 NC_001139.8 Snt2p; DNA binding protein with similarity to the S. pombe Snt2 protein 265864 SNT2 852746 SNT2 Saccharomyces cerevisiae DNA binding protein with similarity to the S. pombe Snt2 protein NP_011384.1 261653 R 4932 CDS NP_011385.1 6321308 852747 266150..267529 1 NC_001139.8 Ceg1p; Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphophatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide 267529 CEG1 852747 CEG1 Saccharomyces cerevisiae Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphophatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide NP_011385.1 266150 D 4932 CDS NP_011386.1 6321309 852748 complement(267728..269194) 1 NC_001139.8 Rsm23p; Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p 269194 RSM23 852748 RSM23 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p NP_011386.1 267728 R 4932 CDS NP_011387.2 37362651 852749 complement(269299..270150) 1 NC_001139.8 Cwc23p; Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p 270150 CWC23 852749 CWC23 Saccharomyces cerevisiae Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p NP_011387.2 269299 R 4932 CDS NP_011388.1 6321311 852750 complement(270398..270781) 1 NC_001139.8 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits; Soh1p 270781 SOH1 852750 SOH1 Saccharomyces cerevisiae Soh1p NP_011388.1 270398 R 4932 CDS NP_011389.1 6321312 852751 271003..272145 1 NC_001139.8 Scs3p; Protein required for inositol prototrophy, identified as an ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis; disputed role in the synthesis of inositol phospholipids from inositol 272145 SCS3 852751 SCS3 Saccharomyces cerevisiae Protein required for inositol prototrophy, identified as an ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis; disputed role in the synthesis of inositol phospholipids from inositol NP_011389.1 271003 D 4932 CDS NP_011390.2 27808705 852752 272526..274328 1 NC_001139.8 Met13p; Isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway 274328 MET13 852752 MET13 Saccharomyces cerevisiae Isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway NP_011390.2 272526 D 4932 CDS NP_011391.1 6321314 852753 complement(274786..276720) 1 NC_001139.8 Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate; Mon1p 276720 MON1 852753 MON1 Saccharomyces cerevisiae Mon1p NP_011391.1 274786 R 4932 CDS NP_011392.1 6321315 852754 277623..278387 1 NC_001139.8 Rps2p; Protein component of the small (40S) subunit, essential for control of translational accuracy; has similarity to E. coli S5 and rat S2 ribosomal proteins 278387 RPS2 852754 RPS2 Saccharomyces cerevisiae Protein component of the small (40S) subunit, essential for control of translational accuracy; has similarity to E. coli S5 and rat S2 ribosomal proteins NP_011392.1 277623 D 4932 CDS NP_011393.1 6321316 852755 complement(278952..280529) 1 NC_001139.8 Nuclear polyadenylated RNA-binding protein; autoregulates mRNA levels; related to human hnRNPs; has nuclear localization signal sequence that binds to Kap104p; required for poly(A) tail length control and nuclear mRNA export; Nab2p 280529 NAB2 852755 NAB2 Saccharomyces cerevisiae Nab2p NP_011393.1 278952 R 4932 CDS NP_011394.1 6321317 852756 complement(280783..281163) 1 NC_001139.8 Proposed gamma subunit of the heterotrimeric G protein that interacts with the receptor Grp1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p; Gpg1p 281163 GPG1 852756 GPG1 Saccharomyces cerevisiae Gpg1p NP_011394.1 280783 R 4932 CDS NP_011395.1 6321318 852757 complement(281640..283943) 1 NC_001139.8 RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome; Prp43p 283943 PRP43 852757 PRP43 Saccharomyces cerevisiae Prp43p NP_011395.1 281640 R 4932 CDS NP_011396.1 6321319 852758 284448..285953 1 NC_001139.8 Protein required for ubiquinone (coenzyme Q) biosynthesis and for respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; Abc1p 285953 ABC1 852758 ABC1 Saccharomyces cerevisiae Abc1p NP_011396.1 284448 D 4932 CDS NP_011398.1 6321321 852761 288518..289315 1 NC_001139.8 Ygl117wp; Putative protein of unknown function 289315 852761 YGL117W Saccharomyces cerevisiae Putative protein of unknown function NP_011398.1 288518 D 4932 CDS NP_011399.1 6321322 852762 289812..291644 1 NC_001139.8 Cell-cycle regulated activator of anaphase-promoting complex/cyclosome (APC/C), which is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; potential Cdc28p substrate; Cdc20p 291644 CDC20 852762 CDC20 Saccharomyces cerevisiae Cdc20p NP_011399.1 289812 D 4932 CDS NP_011400.1 6321323 852763 292036..293004 1 NC_001139.8 Snf4p; Activating gamma subunit of the AMP-activated Snf1p kinase complex (contains Snf1p and a Sip1p/Sip2p/Gal83p family member); activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis 293004 SNF4 852763 SNF4 Saccharomyces cerevisiae Activating gamma subunit of the AMP-activated Snf1p kinase complex (contains Snf1p and a Sip1p/Sip2p/Gal83p family member); activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis NP_011400.1 292036 D 4932 CDS NP_011401.1 6321324 852764 293463..295640 1 NC_001139.8 Ygl114wp; Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters 295640 852764 YGL114W Saccharomyces cerevisiae Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters NP_011401.1 293463 D 4932 CDS NP_011402.1 6321325 852765 295935..297941 1 NC_001139.8 Sld3p; Protein involved in the initiation of DNA replication, required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p 297941 SLD3 852765 SLD3 Saccharomyces cerevisiae Protein involved in the initiation of DNA replication, required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p NP_011402.1 295935 D 4932 CDS NP_011403.1 6321326 852766 complement(298181..299731) 1 NC_001139.8 Taf6p; Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4 299731 TAF6 852766 TAF6 Saccharomyces cerevisiae Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4 NP_011403.1 298181 R 4932 CDS NP_011404.1 6321327 852767 299981..301372 1 NC_001139.8 Nsa1p; Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis 301372 NSA1 852767 NSA1 Saccharomyces cerevisiae Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis NP_011404.1 299981 D 4932 CDS NP_011405.1 6321328 852768 complement(301540..303414) 1 NC_001139.8 Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; Cue3p 303414 CUE3 852768 CUE3 Saccharomyces cerevisiae Cue3p NP_011405.1 301540 R 4932 CDS NP_011407.1 6321330 852770 complement(303652..304074) 1 NC_001139.8 Ygl108cp; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery 304074 852770 YGL108C Saccharomyces cerevisiae Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery NP_011407.1 303652 R 4932 CDS NP_011408.1 6321331 852771 complement(304336..306276) 1 NC_001139.8 Rmd9p; Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes 306276 RMD9 852771 RMD9 Saccharomyces cerevisiae Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes NP_011408.1 304336 R 4932 CDS NP_011409.1 6321332 852772 306563..307012 1 NC_001139.8 Mlc1p; Essential light chain for Myo1p, light chain for Myo2p; stabilizes Myo2p by binding to the neck region; interacts with Myo1p, Iqg1p, and Myo2p to coordinate formation and contraction of the actomyosin ring with targeted membrane deposition 307012 MLC1 852772 MLC1 Saccharomyces cerevisiae Essential light chain for Myo1p, light chain for Myo2p; stabilizes Myo2p by binding to the neck region; interacts with Myo1p, Iqg1p, and Myo2p to coordinate formation and contraction of the actomyosin ring with targeted membrane deposition NP_011409.1 306563 D 4932 CDS NP_011410.1 6321333 852773 307440..308570 1 NC_001139.8 Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids; Arc1p 308570 ARC1 852773 ARC1 Saccharomyces cerevisiae Arc1p NP_011410.1 307440 D 4932 CDS NP_011411.1 6321334 852774 complement(308716..310176) 1 NC_001139.8 Vps73p; Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family 310176 VPS73 852774 VPS73 Saccharomyces cerevisiae Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family NP_011411.1 308716 R 4932 CDS NP_011412.1 6321335 852775 join(310970..311018,311530..311930) 1 NC_001139.8 Rpl28p; Ribosomal protein of the large (60S) ribosomal subunit, has similarity to E. coli L15 and rat L27a ribosomal proteins; may have peptidyl transferase activity; can mutate to cycloheximide resistance 311930 RPL28 852775 RPL28 Saccharomyces cerevisiae Ribosomal protein of the large (60S) ribosomal subunit, has similarity to E. coli L15 and rat L27a ribosomal proteins; may have peptidyl transferase activity; can mutate to cycloheximide resistance NP_011412.1 310970 D 4932 CDS NP_011414.1 6321337 852777 312196..312843 1 NC_001139.8 Ygl101wp; Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p 312843 852777 YGL101W Saccharomyces cerevisiae Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p NP_011414.1 312196 D 4932 CDS NP_011415.1 6321338 852778 313237..314286 1 NC_001139.8 Seh1p; Nuclear pore protein that is part of the evolutionarily conserved Nup84p complex (Nup84p, Nup85p, Nup120p, Nup145p, and Seh1p); homologous to Sec13p 314286 SEH1 852778 SEH1 Saccharomyces cerevisiae Nuclear pore protein that is part of the evolutionarily conserved Nup84p complex (Nup84p, Nup85p, Nup120p, Nup145p, and Seh1p); homologous to Sec13p NP_011415.1 313237 D 4932 CDS NP_011416.1 6321339 852779 314634..316556 1 NC_001139.8 Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm; Lsg1p 316556 LSG1 852779 LSG1 Saccharomyces cerevisiae Lsg1p NP_011416.1 314634 D 4932 CDS NP_011417.1 6321340 852780 317345..318082 1 NC_001139.8 Use1p; Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p 318082 USE1 852780 USE1 Saccharomyces cerevisiae Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p NP_011417.1 317345 D 4932 CDS NP_011418.1 6321341 852782 321785..323233 1 NC_001139.8 Srm1p; Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p 323233 SRM1 852782 SRM1 Saccharomyces cerevisiae Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p NP_011418.1 321785 D 4932 CDS NP_011419.1 6321342 852783 325334..326164 1 NC_001139.8 Tos8p; Homeodomain-containing transcription factor; SBF regulated target gene that in turn regulates expression of genes involved in G1/S phase events such as bud site selection, bud emergence and cell cycle progression; similarity to Cup9p 326164 TOS8 852783 TOS8 Saccharomyces cerevisiae Homeodomain-containing transcription factor; SBF regulated target gene that in turn regulates expression of genes involved in G1/S phase events such as bud site selection, bud emergence and cell cycle progression; similarity to Cup9p NP_011419.1 325334 D 4932 CDS NP_011420.1 6321343 852785 complement(328877..330610) 1 NC_001139.8 Vps45p; Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment 330610 VPS45 852785 VPS45 Saccharomyces cerevisiae Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment NP_011420.1 328877 R 4932 CDS NP_011421.1 6321344 852786 complement(331121..334468) 1 NC_001139.8 Pan2p; Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes 334468 PAN2 852786 PAN2 Saccharomyces cerevisiae Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes NP_011421.1 331121 R 4932 CDS NP_011422.1 6321345 852787 334889..337642 1 NC_001139.8 Spc105p; Protein required for accurate chromosome segregation, localizes to the nuclear side of the spindle pole body; forms a complex with Ydr532cp 337642 SPC105 852787 SPC105 Saccharomyces cerevisiae Protein required for accurate chromosome segregation, localizes to the nuclear side of the spindle pole body; forms a complex with Ydr532cp NP_011422.1 334889 D 4932 CDS NP_011423.1 6321346 852788 337909..341862 1 NC_001139.8 Nup145p; Essential nucleoporin, catalyzes its own cleavage in vivo to generate a C-terminal fragment that assembles into the Nup84p subcomplex of the nuclear pore complex, and an N-terminal fragment of unknown function that is homologous to Nup100p 341862 NUP145 852788 NUP145 Saccharomyces cerevisiae Essential nucleoporin, catalyzes its own cleavage in vivo to generate a C-terminal fragment that assembles into the Nup84p subcomplex of the nuclear pore complex, and an N-terminal fragment of unknown function that is homologous to Nup100p NP_011423.1 337909 D 4932 CDS NP_011424.1 6321347 852789 complement(342059..343045) 1 NC_001139.8 Nbp35p; Essential iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases 343045 NBP35 852789 NBP35 Saccharomyces cerevisiae Essential iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases NP_011424.1 342059 R 4932 CDS NP_011425.1 6321348 852790 343322..344587 1 NC_001139.8 Lif1p; Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein 344587 LIF1 852790 LIF1 Saccharomyces cerevisiae Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein NP_011425.1 343322 D 4932 CDS NP_011426.1 6321349 852791 complement(344794..345156) 1 NC_001139.8 Mf(alpha)2p; Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2 345156 MF(ALPHA)2 852791 MF(ALPHA)2 Saccharomyces cerevisiae Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2 NP_011426.1 344794 R 4932 CDS NP_011428.1 6321351 852793 complement(join(346409..346811,346897..346907)) 1 NC_001139.8 Protein involved in error-free postreplication DNA repair; forms a heteromeric complex with Ubc13p that has a ubiquitin-conjugating activity; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p; Mms2p 346907 MMS2 852793 MMS2 Saccharomyces cerevisiae Mms2p NP_011428.1 346409 R 4932 CDS NP_011429.1 6321352 852794 347122..349371 1 NC_001139.8 Mad1p; Coiled-coil protein involved in the spindle-assembly checkpoint; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p 349371 MAD1 852794 MAD1 Saccharomyces cerevisiae Coiled-coil protein involved in the spindle-assembly checkpoint; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p NP_011429.1 347122 D 4932 CDS NP_011430.1 6321353 852795 349619..350443 1 NC_001139.8 Ygl085wp; Putative protein of unknown function, has homology to Staphylococcus aureus nuclease; green fluorescent protein (GFP)-fusion protein localizes to mitochondria and is induced in response to the DNA-damaging agent MMS 350443 852795 YGL085W Saccharomyces cerevisiae Putative protein of unknown function, has homology to Staphylococcus aureus nuclease; green fluorescent protein (GFP)-fusion protein localizes to mitochondria and is induced in response to the DNA-damaging agent MMS NP_011430.1 349619 D 4932 CDS NP_011431.1 6321354 852796 complement(350619..352301) 1 NC_001139.8 Plasma membrane protein with a possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases; Gup1p 352301 GUP1 852796 GUP1 Saccharomyces cerevisiae Gup1p NP_011431.1 350619 R 4932 CDS NP_011432.1 6321355 852797 353061..355475 1 NC_001139.8 Scy1p; Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase 355475 SCY1 852797 SCY1 Saccharomyces cerevisiae Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase NP_011432.1 353061 D 4932 CDS NP_011433.1 6321356 852798 355830..356975 1 NC_001139.8 Ygl082wp; Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene 356975 852798 YGL082W Saccharomyces cerevisiae Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene NP_011433.1 355830 D 4932 CDS NP_011434.1 6321357 852799 357380..358342 1 NC_001139.8 Ygl081wp; Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis 358342 852799 YGL081W Saccharomyces cerevisiae Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis NP_011434.1 357380 D 4932 CDS NP_011435.1 6321358 852800 358639..359031 1 NC_001139.8 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Fmp37p 359031 FMP37 852800 FMP37 Saccharomyces cerevisiae Fmp37p NP_011435.1 358639 D 4932 CDS NP_011436.1 6321359 852801 359447..360103 1 NC_001139.8 Ygl079wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endosome; identified as a transcriptional activator in a high-throughput yeast one-hybrid assay 360103 852801 YGL079W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endosome; identified as a transcriptional activator in a high-throughput yeast one-hybrid assay NP_011436.1 359447 D 4932 CDS NP_011437.1 6321360 852802 complement(360291..361862) 1 NC_001139.8 Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis; Dbp3p 361862 DBP3 852802 DBP3 Saccharomyces cerevisiae Dbp3p NP_011437.1 360291 R 4932 CDS NP_011438.1 6321361 852803 complement(362228..363919) 1 NC_001139.8 Hnm1p; Choline/ethanolamine transporter (permease) that also controls the uptake of nitrogen mustard; expression is co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol 363919 HNM1 852803 HNM1 Saccharomyces cerevisiae Choline/ethanolamine transporter (permease) that also controls the uptake of nitrogen mustard; expression is co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol NP_011438.1 362228 R 4932 CDS NP_011439.1 6321362 852804 complement(join(364338..364967,365436..365529,365989..365999)) 1 NC_001139.8 Rpl7ap; Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Bp and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2) 365999 RPL7A 852804 RPL7A Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Bp and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2) NP_011439.1 364338 R 4932 CDS NP_011440.1 6321363 852805 complement(366928..368091) 1 NC_001139.8 Mps2p; Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p 368091 MPS2 852805 MPS2 Saccharomyces cerevisiae Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p NP_011440.1 366928 R 4932 CDS NP_011442.1 6321364 852806 368756..371257 1 NC_001139.8 Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated; Hsf1p 371257 HSF1 852806 HSF1 Saccharomyces cerevisiae Hsf1p NP_011442.1 368756 D 4932 CDS NP_011444.1 6321367 852809 372015..374087 1 NC_001139.8 Transcription factor involved in iron utilization and homeostasis; binds the consensus site PyPuCACCCPu and activates the expression of target genes in response to changes in iron availability; Aft1p 374087 AFT1 852809 AFT1 Saccharomyces cerevisiae Aft1p NP_011444.1 372015 D 4932 CDS NP_011445.1 6321368 852810 complement(374462..374830) 1 NC_001139.8 Rpb9p; RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site; involved in telomere maintenance 374830 RPB9 852810 RPB9 Saccharomyces cerevisiae RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site; involved in telomere maintenance NP_011445.1 374462 R 4932 CDS NP_011447.1 6321369 852811 375090..375674 1 NC_001139.8 Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth; Mnp1p 375674 MNP1 852811 MNP1 Saccharomyces cerevisiae Mnp1p NP_011447.1 375090 D 4932 CDS NP_011448.1 6321371 852813 376104..377258 1 NC_001139.8 Npy1p; NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes 377258 NPY1 852813 NPY1 Saccharomyces cerevisiae NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes NP_011448.1 376104 D 4932 CDS NP_011449.1 6321372 852814 377612..379585 1 NC_001139.8 Sgf73p; 73 kDa subunit of SAGA histone acetyltransferase complex; involved in formation of the preinitiation complex assembly at promoters 379585 SGF73 852814 SGF73 Saccharomyces cerevisiae 73 kDa subunit of SAGA histone acetyltransferase complex; involved in formation of the preinitiation complex assembly at promoters NP_011449.1 377612 D 4932 CDS NP_011450.1 6321373 852815 complement(379763..381274) 1 NC_001139.8 Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol; Alg2p 381274 ALG2 852815 ALG2 Saccharomyces cerevisiae Alg2p NP_011450.1 379763 R 4932 CDS NP_011451.1 6321374 852816 complement(381526..383211) 1 NC_001139.8 Mrh4p; Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function 383211 MRH4 852816 MRH4 Saccharomyces cerevisiae Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function NP_011451.1 381526 R 4932 CDS NP_011452.1 6321375 852817 383657..384769 1 NC_001139.8 Pus2p; Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification 384769 PUS2 852817 PUS2 Saccharomyces cerevisiae Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification NP_011452.1 383657 D 4932 CDS NP_011453.1 6321376 852818 385199..388735 1 NC_001139.8 Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc2p but differentially regulated; mutations in the human homolog are associated with lactic acidosis; Pyc1p 388735 PYC1 852818 PYC1 Saccharomyces cerevisiae Pyc1p NP_011453.1 385199 D 4932 CDS NP_011454.1 6321377 852819 complement(388971..389714) 1 NC_001139.8 Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis; Duo1p 389714 DUO1 852819 DUO1 Saccharomyces cerevisiae Duo1p NP_011454.1 388971 R 4932 CDS NP_011455.1 6321378 852820 390070..391995 1 NC_001139.8 Ybp2p; Protein with a role in resistance to oxidative stress; has similarity to Ybp1p, which is involved in regulation of the transcription factor Yap1p via oxidation of specific cysteine residues 391995 YBP2 852820 YBP2 Saccharomyces cerevisiae Protein with a role in resistance to oxidative stress; has similarity to Ybp1p, which is involved in regulation of the transcription factor Yap1p via oxidation of specific cysteine residues NP_011455.1 390070 D 4932 CDS NP_011456.2 27808706 852821 392228..393703 1 NC_001139.8 Ygl059wp; Protein kinase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 393703 852821 YGL059W Saccharomyces cerevisiae Protein kinase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_011456.2 392228 D 4932 CDS NP_011457.1 6321380 852822 393992..394510 1 NC_001139.8 Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (with Rad18p), sporulation, telomere silencing, and ubiquitin-mediated N-end rule protein degradation (with Ubr1p); Rad6p 394510 RAD6 852822 RAD6 Saccharomyces cerevisiae Rad6p NP_011457.1 393992 D 4932 CDS NP_011458.1 6321381 852823 complement(394972..395835) 1 NC_001139.8 Ygl057cp; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant exhibits a growth defect on a non-fermentable (respiratory) carbon source 395835 852823 YGL057C Saccharomyces cerevisiae Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant exhibits a growth defect on a non-fermentable (respiratory) carbon source NP_011458.1 394972 R 4932 CDS NP_011459.1 6321382 852824 complement(396041..397624) 1 NC_001139.8 Sds23p; One of two S. cerevisiae homologs (Sds23p and Sds24p) of the Schizosaccharomyces pombe Sds23 protein, which genetic studies have implicated in APC/cyclosome regulation 397624 SDS23 852824 SDS23 Saccharomyces cerevisiae One of two S. cerevisiae homologs (Sds23p and Sds24p) of the Schizosaccharomyces pombe Sds23 protein, which genetic studies have implicated in APC/cyclosome regulation NP_011459.1 396041 R 4932 CDS NP_011460.1 6321383 852825 398631..400163 1 NC_001139.8 Ole1p; Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria 400163 OLE1 852825 OLE1 Saccharomyces cerevisiae Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria NP_011460.1 398631 D 4932 CDS NP_011461.1 6321384 852826 complement(400874..401290) 1 NC_001139.8 Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; Erv14p 401290 ERV14 852826 ERV14 Saccharomyces cerevisiae Erv14p NP_011461.1 400874 R 4932 CDS NP_011462.1 6321385 852828 402592..403305 1 NC_001139.8 Prm8p; Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family 403305 PRM8 852828 PRM8 Saccharomyces cerevisiae Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family NP_011462.1 402592 D 4932 CDS NP_011464.1 6321387 852830 403690..404394 1 NC_001139.8 Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles; Mst27p 404394 MST27 852830 MST27 Saccharomyces cerevisiae Mst27p NP_011464.1 403690 D 4932 CDS NP_011465.1 6321388 852832 405779..406600 1 NC_001139.8 Tyw3p; Protein required for the synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions 406600 TYW3 852832 TYW3 Saccharomyces cerevisiae Protein required for the synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions NP_011465.1 405779 D 4932 CDS NP_011466.1 6321389 852833 complement(406863..409607) 1 NC_001139.8 Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); homologous to Tif4631p; Tif4632p 409607 TIF4632 852833 TIF4632 Saccharomyces cerevisiae Tif4632p NP_011466.1 406863 R 4932 CDS NP_011467.1 6321390 852834 complement(410072..411289) 1 NC_001139.8 Rpt6p; One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle 411289 RPT6 852834 RPT6 Saccharomyces cerevisiae One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle NP_011467.1 410072 R 4932 CDS NP_011468.1 6321391 852835 411555..412163 1 NC_001139.8 Catalytic component of UDP-GlcNAc transferase, required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER membrane via interaction with Alg14p; similar to bacterial and human glycosyltransferases; Alg13p 412163 ALG13 852835 ALG13 Saccharomyces cerevisiae Alg13p NP_011468.1 411555 D 4932 CDS NP_011470.2 27808707 852837 414106..415734 1 NC_001139.8 Rim8p; Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalF 415734 RIM8 852837 RIM8 Saccharomyces cerevisiae Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalF NP_011470.2 414106 D 4932 CDS NP_011471.1 6321394 852838 complement(416150..417040) 1 NC_001139.8 Rna15p; Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p 417040 RNA15 852838 RNA15 Saccharomyces cerevisiae Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p NP_011471.1 416150 R 4932 CDS NP_011472.1 6321395 852839 417487..418416 1 NC_001139.8 General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; Dst1p 418416 DST1 852839 DST1 Saccharomyces cerevisiae Dst1p NP_011472.1 417487 D 4932 CDS NP_878074.1 33438792 1466454 complement(418709..418891) 1 NC_001139.8 Ygl041c-bp; Putative protein of unknown function; identified by fungal homology and RT-PCR 418891 1466454 YGL041C-B Saccharomyces cerevisiae Putative protein of unknown function; identified by fungal homology and RT-PCR NP_878074.1 418709 R 4932 CDS NP_001106172.1 162949219 5814844 419047..419295 1 NC_001139.8 Ygl041w-ap; Putative protein of unknown function, conserved in fungi; identified by expression profiling and mass spectrometry 419295 5814844 YGL041W-A Saccharomyces cerevisiae Putative protein of unknown function, conserved in fungi; identified by expression profiling and mass spectrometry NP_001106172.1 419047 D 4932 CDS NP_011475.1 6321398 852842 complement(419533..420561) 1 NC_001139.8 Hem2p; Delta-aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of delta-aminolevulinic acid to porphobilinogen, the second step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus 420561 HEM2 852842 HEM2 Saccharomyces cerevisiae Delta-aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of delta-aminolevulinic acid to porphobilinogen, the second step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus NP_011475.1 419533 R 4932 CDS NP_011476.1 6321399 852844 423967..425013 1 NC_001139.8 Ygl039wp; Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol) 425013 852844 YGL039W Saccharomyces cerevisiae Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol) NP_011476.1 423967 D 4932 CDS NP_011477.1 6321400 852845 complement(425368..426810) 1 NC_001139.8 Och1p; Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins 426810 OCH1 852845 OCH1 Saccharomyces cerevisiae Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins NP_011477.1 425368 R 4932 CDS NP_011478.1 6321401 852846 complement(427303..427953) 1 NC_001139.8 Pnc1p; Nicotinamidase that converts nicotinamide to nicotinic acid as part of the NAD(+) salvage pathway, required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span 427953 PNC1 852846 PNC1 Saccharomyces cerevisiae Nicotinamidase that converts nicotinamide to nicotinic acid as part of the NAD(+) salvage pathway, required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span NP_011478.1 427303 R 4932 CDS NP_011479.1 6321402 852847 428606..431335 1 NC_001139.8 Ygl036wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YGL036W is not an essential gene 431335 852847 YGL036W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YGL036W is not an essential gene NP_011479.1 428606 D 4932 CDS NP_011480.1 6321403 852848 complement(431553..433067) 1 NC_001139.8 Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; Mig1p 433067 MIG1 852848 MIG1 Saccharomyces cerevisiae Mig1p NP_011480.1 431553 R 4932 CDS NP_011482.2 9755333 852850 join(435630..435684,435755..436356) 1 NC_001139.8 Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair; Hop2p 436356 HOP2 852850 HOP2 Saccharomyces cerevisiae Hop2p NP_011482.2 435630 D 4932 CDS NP_011483.1 6321406 852851 complement(436575..436838) 1 NC_001139.8 Aga2p; Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds 436838 AGA2 852851 AGA2 Saccharomyces cerevisiae Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds NP_011483.1 436575 R 4932 CDS NP_011484.1 6321407 852852 complement(437472..437939) 1 NC_001139.8 Rpl24ap; Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Bp and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate 437939 RPL24A 852852 RPL24A Saccharomyces cerevisiae Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Bp and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate NP_011484.1 437472 R 4932 CDS NP_011485.1 6321408 852853 join(439096..439098,439329..439643) 1 NC_001139.8 Rpl30p; Protein component of the large (60S) ribosomal subunit, has similarity to rat L30 ribosomal protein; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript 439643 RPL30 852853 RPL30 Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, has similarity to rat L30 ribosomal protein; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript NP_011485.1 439096 D 4932 CDS NP_011486.1 6321409 852854 440068..440430 1 NC_001139.8 Protein involved in nucleolar integrity and processing of the pre-rRNA for the 60S ribosome subunit; transcript is induced in response to cytotoxic stress but not genotoxic stress; Cgr1p 440430 CGR1 852854 CGR1 Saccharomyces cerevisiae Cgr1p NP_011486.1 440068 D 4932 CDS NP_011487.1 6321410 852856 complement(441286..442914) 1 NC_001139.8 Scw11p; Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p 442914 SCW11 852856 SCW11 Saccharomyces cerevisiae Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p NP_011487.1 441286 R 4932 CDS NP_011488.1 6321411 852857 complement(443647..446148) 1 NC_001139.8 Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress; Cwh41p 446148 CWH41 852857 CWH41 Saccharomyces cerevisiae Cwh41p NP_011488.1 443647 R 4932 CDS NP_011489.1 6321412 852858 complement(446417..448540) 1 NC_001139.8 Tryptophan synthase involved in tryptophan biosynthesis, regulated by the general control system of amino acid biosynthesis; Trp5p 448540 TRP5 852858 TRP5 Saccharomyces cerevisiae Trp5p NP_011489.1 446417 R 4932 CDS NP_011490.2 37362652 852860 complement(448769..449962) 1 NC_001139.8 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor; Pgd1p 449962 PGD1 852860 PGD1 Saccharomyces cerevisiae Pgd1p NP_011490.2 448769 R 4932 CDS NP_011492.1 6321415 852861 complement(450202..452109) 1 NC_001139.8 Protein binding phosphatidylinositol 3-phosphate, involved in telomere-proximal repression of gene expression; similar to Fab1 and Vps27; Pib2p 452109 PIB2 852861 PIB2 Saccharomyces cerevisiae Pib2p NP_011492.1 450202 R 4932 CDS NP_011493.1 6321416 852862 452409..454565 1 NC_001139.8 Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; forms a subcomplex with Ost3p and Ost4p and is directly involved in catalysis; Stt3p 454565 STT3 852862 STT3 Saccharomyces cerevisiae Stt3p NP_011493.1 452409 D 4932 CDS NP_011494.1 6321417 852863 454790..457072 1 NC_001139.8 Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; similar to Alk2p and to mammalian haspins; Alk1p 457072 ALK1 852863 ALK1 Saccharomyces cerevisiae Alk1p NP_011494.1 454790 D 4932 CDS NP_011495.1 6321418 852864 complement(457168..457875) 1 NC_001139.8 Subunit of the GET complex; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance; Get1p 457875 GET1 852864 GET1 Saccharomyces cerevisiae Get1p NP_011495.1 457168 R 4932 CDS NP_011496.1 6321419 852865 458161..458997 1 NC_001139.8 Ckb1p; Beta regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB2, the many substrates include transcription factors and all RNA polymerases 458997 CKB1 852865 CKB1 Saccharomyces cerevisiae Beta regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB2, the many substrates include transcription factors and all RNA polymerases NP_011496.1 458161 D 4932 CDS NP_011497.1 6321420 852866 complement(459115..459669) 1 NC_001139.8 Specialized J-protein that functions with Hsp70 in Fe-S cluster biogenesis in mitochondria, involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix; Jac1p 459669 JAC1 852866 JAC1 Saccharomyces cerevisiae Jac1p NP_011497.1 459115 R 4932 CDS NP_011498.1 6321421 852867 459859..461370 1 NC_001139.8 Ate1p; Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway 461370 ATE1 852867 ATE1 Saccharomyces cerevisiae Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway NP_011498.1 459859 D 4932 CDS NP_011499.1 6321422 852868 461671..464916 1 NC_001139.8 Karyopherin beta, responsible for import of the Toa1p-Toa2p complex into the nucleus; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance; Kap122p 464916 KAP122 852868 KAP122 Saccharomyces cerevisiae Kap122p NP_011499.1 461671 D 4932 CDS NP_011500.1 6321423 852869 complement(465048..465440) 1 NC_001139.8 Ygl015cp 465440 852869 YGL015C Saccharomyces cerevisiae Ygl015cp NP_011500.1 465048 R 4932 CDS NP_011501.1 6321424 852870 466146..468812 1 NC_001139.8 Puf4p; Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors 468812 PUF4 852870 PUF4 Saccharomyces cerevisiae Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors NP_011501.1 466146 D 4932 CDS NP_011502.1 6321425 852871 complement(469097..472303) 1 NC_001139.8 Zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; Pdr1p 472303 PDR1 852871 PDR1 Saccharomyces cerevisiae Pdr1p NP_011502.1 469097 R 4932 CDS NP_011503.1 6321426 852872 472860..474281 1 NC_001139.8 Erg4p; C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol 474281 ERG4 852872 ERG4 Saccharomyces cerevisiae C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol NP_011503.1 472860 D 4932 CDS NP_011504.1 6321427 852873 complement(474494..475252) 1 NC_001139.8 Scl1p; Alpha subunit of the 20S core complex of the 26S proteasome involved in the degradation of ubiquitinated substrates; essential for growth; detected in the mitochondria 475252 SCL1 852873 SCL1 Saccharomyces cerevisiae Alpha subunit of the 20S core complex of the 26S proteasome involved in the degradation of ubiquitinated substrates; essential for growth; detected in the mitochondria NP_011504.1 474494 R 4932 CDS NP_011505.1 6321428 852874 475550..476074 1 NC_001139.8 Ygl010wp; Putative protein of unknown function; YGL010W is not an essential gene 476074 852874 YGL010W Saccharomyces cerevisiae Putative protein of unknown function; YGL010W is not an essential gene NP_011505.1 475550 D 4932 CDS NP_011506.1 6321429 852875 complement(476318..478657) 1 NC_001139.8 Leu1p; Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway 478657 LEU1 852875 LEU1 Saccharomyces cerevisiae Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway NP_011506.1 476318 R 4932 CDS NP_011507.1 6321430 852876 complement(479915..482671) 1 NC_001139.8 Pma1p; Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; part of the P2 subgroup of cation-transporting ATPases 482671 PMA1 852876 PMA1 Saccharomyces cerevisiae Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; part of the P2 subgroup of cation-transporting ATPases NP_011507.1 479915 R 4932 CDS NP_878075.1 33438793 1466455 complement(482946..483032) 1 NC_001139.8 Ygl007c-ap; Putative protein of unknown function, identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; haploid deletion strain exhibits a slow-growth phenotype 483032 1466455 YGL007C-A Saccharomyces cerevisiae Putative protein of unknown function, identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; haploid deletion strain exhibits a slow-growth phenotype NP_878075.1 482946 R 4932 CDS NP_878076.1 33438794 1466456 485428..485538 1 NC_001139.8 Ygl006w-ap; Putative protein of unknown function; identified by SAGE 485538 1466456 YGL006W-A Saccharomyces cerevisiae Putative protein of unknown function; identified by SAGE NP_878076.1 485428 D 4932 CDS NP_011509.1 6321432 852878 485925..489446 1 NC_001139.8 Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a; Pmc1p 489446 PMC1 852878 PMC1 Saccharomyces cerevisiae Pmc1p NP_011509.1 485925 D 4932 CDS NP_011510.1 6321433 852879 complement(489712..490551) 1 NC_001139.8 Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; Cog7p 490551 COG7 852879 COG7 Saccharomyces cerevisiae Cog7p NP_011510.1 489712 R 4932 CDS NP_011511.1 6321434 852880 complement(490707..491960) 1 NC_001139.8 Rpn14p; Putative non-ATPase subunit of the 19S regulatory particle of the 26S proteasome; localized to the cytoplasm 491960 RPN14 852880 RPN14 Saccharomyces cerevisiae Putative non-ATPase subunit of the 19S regulatory particle of the 26S proteasome; localized to the cytoplasm NP_011511.1 490707 R 4932 CDS NP_011512.1 6321435 852881 complement(492478..494178) 1 NC_001139.8 Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including CDC20, ASE1, CIN8 and FIN1; Cdh1p 494178 CDH1 852881 CDH1 Saccharomyces cerevisiae Cdh1p NP_011512.1 492478 R 4932 CDS NP_011513.1 6321436 852882 494521..495171 1 NC_001139.8 Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Erp6p 495171 ERP6 852882 ERP6 Saccharomyces cerevisiae Erp6p NP_011513.1 494521 D 4932 CDS NP_011514.1 6321437 852883 complement(495457..496506) 1 NC_001139.8 Erg26p; C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis 496506 ERG26 852883 ERG26 Saccharomyces cerevisiae C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis NP_011514.1 495457 R 4932 CDS NP_011515.2 9755334 852884 complement(join(497137..497369,497463..497941,498004..498038)) 1 NC_001139.8 Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae; Aml1p 498038 AML1 852884 AML1 Saccharomyces cerevisiae Aml1p NP_011515.2 497137 R 4932 CDS NP_011516.1 6321439 852885 complement(498480..499910) 1 NC_001139.8 Swc4p; Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex 499910 SWC4 852885 SWC4 Saccharomyces cerevisiae Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex NP_011516.1 498480 R 4932 CDS NP_011517.1 6321440 852886 500136..502370 1 NC_001139.8 Ubiquitin-protein ligase, member of the cullin family with similarity to Cdc53p and human CUL3; required for ubiquitin-dependent degredation of the RNA Polymerase II subunit RPO21; Cul3p 502370 CUL3 852886 CUL3 Saccharomyces cerevisiae Cul3p NP_011517.1 500136 D 4932 CDS NP_011518.1 6321441 852887 502942..504330 1 NC_001139.8 Pex31p; Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p 504330 PEX31 852887 PEX31 Saccharomyces cerevisiae Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p NP_011518.1 502942 D 4932 CDS NP_011519.1 6321442 852888 complement(504661..505863) 1 NC_001139.8 Tfg2p; TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30 505863 TFG2 852888 TFG2 Saccharomyces cerevisiae TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30 NP_011519.1 504661 R 4932 CDS NP_011520.2 41629693 852889 506074..506829 1 NC_001139.8 Splicing factor involved in the positioning of the 3' splice site during the second catalytic step of splicing, part of snRNP U5, interacts with Slu7p; Prp18p 506829 PRP18 852889 PRP18 Saccharomyces cerevisiae Prp18p NP_011520.2 506074 D 4932 CDS NP_011521.1 6321444 852890 506973..507944 1 NC_001139.8 Muq1p; Choline phosphate cytidylyltransferase, catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases 507944 MUQ1 852890 MUQ1 Saccharomyces cerevisiae Choline phosphate cytidylyltransferase, catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases NP_011521.1 506973 D 4932 CDS NP_011522.1 6321445 852891 complement(508114..508368) 1 NC_001139.8 Stf2p; Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein 508368 STF2 852891 STF2 Saccharomyces cerevisiae Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein NP_011522.1 508114 R 4932 CDS NP_011523.1 6321446 852892 complement(509051..511006) 1 NC_001139.8 t-SNARE protein important for fusion of secretory vesicles with the plasma membrane; similar to but not functionally redundant with Spo20p; SNAP-25 homolog; Sec9p 511006 SEC9 852892 SEC9 Saccharomyces cerevisiae Sec9p NP_011523.1 509051 R 4932 CDS NP_011524.1 6321447 852893 511549..512736 1 NC_001139.8 Nma2p; Nicotinic acid mononucleotide adenylyltransferase, involved in NAD(+) salvage pathway 512736 NMA2 852893 NMA2 Saccharomyces cerevisiae Nicotinic acid mononucleotide adenylyltransferase, involved in NAD(+) salvage pathway NP_011524.1 511549 D 4932 CDS NP_011526.1 6321449 852895 513163..514344 1 NC_001139.8 Ygr012wp; Putative cysteine synthase, localized to the mitochondrial outer membrane 514344 852895 YGR012W Saccharomyces cerevisiae Putative cysteine synthase, localized to the mitochondrial outer membrane NP_011526.1 513163 D 4932 CDS NP_011527.1 6321450 852896 514558..516420 1 NC_001139.8 Snu71p; Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart 516420 SNU71 852896 SNU71 Saccharomyces cerevisiae Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart NP_011527.1 514558 D 4932 CDS NP_011528.1 6321451 852897 516947..520867 1 NC_001139.8 Mucin family member involved in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate; Msb2p 520867 MSB2 852897 MSB2 Saccharomyces cerevisiae Msb2p NP_011528.1 516947 D 4932 CDS NP_011529.1 6321452 852898 complement(521094..522080) 1 NC_001139.8 Ygr015cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion 522080 852898 YGR015C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion NP_011529.1 521094 R 4932 CDS NP_011530.1 6321453 852899 522265..522837 1 NC_001139.8 Ygr016wp; Putative protein of unknown function 522837 852899 YGR016W Saccharomyces cerevisiae Putative protein of unknown function NP_011530.1 522265 D 4932 CDS NP_011531.1 6321454 852900 523791..524684 1 NC_001139.8 Ygr017wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm 524684 852900 YGR017W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm NP_011531.1 523791 D 4932 CDS NP_011533.1 6321456 852902 525233..526648 1 NC_001139.8 Uga1p; Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization 526648 UGA1 852902 UGA1 Saccharomyces cerevisiae Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization NP_011533.1 525233 D 4932 CDS NP_011534.1 6321457 852903 complement(526977..527333) 1 NC_001139.8 Vma7p; Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane 527333 VMA7 852903 VMA7 Saccharomyces cerevisiae Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane NP_011534.1 526977 R 4932 CDS NP_011535.1 6321458 852904 527636..528508 1 NC_001139.8 Ygr021wp; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 528508 852904 YGR021W Saccharomyces cerevisiae Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_011535.1 527636 D 4932 CDS NP_011537.1 6321459 852905 529268..530923 1 NC_001139.8 Protein with both structural and functional similarity to Mid2p, which is a plasma membrane sensor required for cell integrity signaling during pheromone-induced morphogenesis; suppresses rgd1 null mutations; Mtl1p 530923 MTL1 852905 MTL1 Saccharomyces cerevisiae Mtl1p NP_011537.1 529268 D 4932 CDS NP_011538.1 6321461 852908 complement(531887..532600) 1 NC_001139.8 tRNAHis guanylyltransferase, adds a guanosine residue to the 5' end of tRNAHis after transcription and RNase P cleavage; couples nuclear division and migration to cell budding and cytokinesis; essential enzyme conserved among eukaryotes; Thg1p 532600 THG1 852908 THG1 Saccharomyces cerevisiae Thg1p NP_011538.1 531887 R 4932 CDS NP_011540.1 6321463 852910 532989..533825 1 NC_001139.8 Ygr026wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery 533825 852910 YGR026W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery NP_011540.1 532989 D 4932 CDS NP_011541.1 6321464 852911 complement(534136..534462) 1 NC_001139.8 Rps25ap; Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Bp and has similarity to rat S25 ribosomal protein 534462 RPS25A 852911 RPS25A Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Bp and has similarity to rat S25 ribosomal protein NP_011541.1 534136 R 4932 CDS NP_058158.1 7839171 852913 join(536061..537365,537367..541329) 1 NC_001139.8 Ygr027w-bp; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 541329 852913 YGR027W-B Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_058158.1 536061 D 4932 CDS NP_058159.1 7839170 852912 536061..537383 1 NC_001139.8 Ygr027w-ap; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 537383 852912 YGR027W-A Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_058159.1 536061 D 4932 CDS NP_011542.1 6321465 852915 542207..543295 1 NC_001139.8 Msp1p; Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase 543295 MSP1 852915 MSP1 Saccharomyces cerevisiae Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase NP_011542.1 542207 D 4932 CDS NP_011543.2 6681846 852916 join(543557..543642,543726..544209) 1 NC_001139.8 Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as part of a disulfide relay system that promotes IMS retention of imported proteins; ortholog of human hepatopoietin (ALR); Erv1p 544209 ERV1 852916 ERV1 Saccharomyces cerevisiae Erv1p NP_011543.2 543557 D 4932 CDS NP_011544.1 6321467 852918 complement(545685..546161) 1 NC_001139.8 Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; Pop6p 546161 POP6 852918 POP6 Saccharomyces cerevisiae Pop6p NP_011544.1 545685 R 4932 CDS NP_011545.1 6321468 852919 546445..547473 1 NC_001139.8 Ygr031wp; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 547473 852919 YGR031W Saccharomyces cerevisiae Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_011545.1 546445 D 4932 CDS NP_011546.1 6321469 852920 548268..553955 1 NC_001139.8 Gsc2p; Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p) 553955 GSC2 852920 GSC2 Saccharomyces cerevisiae Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p) NP_011546.1 548268 D 4932 CDS NP_011547.1 6321470 852921 complement(554252..554971) 1 NC_001139.8 Tim21p; Constituent of the mitochondrial inner membrane presequence translocase (TIM23 complex); may regulate protein import by binding to both the translocase of the outer membrane (TOM) and presequence-associated motor (PAM) complexes 554971 TIM21 852921 TIM21 Saccharomyces cerevisiae Constituent of the mitochondrial inner membrane presequence translocase (TIM23 complex); may regulate protein import by binding to both the translocase of the outer membrane (TOM) and presequence-associated motor (PAM) complexes NP_011547.1 554252 R 4932 CDS NP_011548.2 116006491 852922 join(555816..555834,556312..556676) 1 NC_001139.8 Rpl26bp; Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Ap and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA 556676 RPL26B 852922 RPL26B Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Ap and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA NP_011548.2 555816 D 4932 CDS NP_011549.1 6321472 852923 complement(557076..557426) 1 NC_001139.8 Ygr035cp; Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance 557426 852923 YGR035C Saccharomyces cerevisiae Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance NP_011549.1 557076 R 4932 CDS NP_878077.1 33438795 1466457 557569..557790 1 NC_001139.8 Ygr035w-ap; Putative protein of unknown function 557790 1466457 YGR035W-A Saccharomyces cerevisiae Putative protein of unknown function NP_878077.1 557569 D 4932 CDS NP_011550.1 6321473 852924 complement(558153..558872) 1 NC_001139.8 Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation; Cax4p 558872 CAX4 852924 CAX4 Saccharomyces cerevisiae Cax4p NP_011550.1 558153 R 4932 CDS NP_011551.1 6321474 852925 complement(559735..559998) 1 NC_001139.8 Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; Acb1p 559998 ACB1 852925 ACB1 Saccharomyces cerevisiae Acb1p NP_011551.1 559735 R 4932 CDS NP_011552.1 6321475 852926 560686..561354 1 NC_001139.8 Orm1p; Evolutionarily conserved protein with similarity to Orm2p, required for resistance to agents that induce the unfolded protein response; human ortholog is located in the endoplasmic reticulum 561354 ORM1 852926 ORM1 Saccharomyces cerevisiae Evolutionarily conserved protein with similarity to Orm2p, required for resistance to agents that induce the unfolded protein response; human ortholog is located in the endoplasmic reticulum NP_011552.1 560686 D 4932 CDS NP_058160.1 7839173 852928 complement(join(562203..566165,566167..567471)) 1 NC_001139.8 Ygr038c-bp; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 567471 852928 YGR038C-B Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_058160.1 562203 R 4932 CDS NP_058161.1 7839172 852929 complement(566149..567471) 1 NC_001139.8 Ygr038c-ap; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 567471 852929 YGR038C-A Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_058161.1 566149 R 4932 CDS NP_011554.1 6321477 852931 575402..576508 1 NC_001139.8 Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains; Kss1p 576508 KSS1 852931 KSS1 Saccharomyces cerevisiae Kss1p NP_011554.1 575402 D 4932 CDS NP_011555.1 6321478 852932 577491..579134 1 NC_001139.8 Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole; Bud9p 579134 BUD9 852932 BUD9 Saccharomyces cerevisiae Bud9p NP_011555.1 577491 D 4932 CDS NP_011556.1 6321479 852933 579480..580295 1 NC_001139.8 Ygr042wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus 580295 852933 YGR042W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus NP_011556.1 579480 D 4932 CDS NP_011557.1 6321480 852934 complement(580439..581440) 1 NC_001139.8 Protein of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; null mutant non-quiescent cells exhibit reduced reproductive capacity; Nqm1p 581440 NQM1 852934 NQM1 Saccharomyces cerevisiae Nqm1p NP_011557.1 580439 R 4932 CDS NP_011558.1 6321481 852935 complement(582994..583896) 1 NC_001139.8 Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-a2 regulator; mediates cell type control of sporulation; Rme1p 583896 RME1 852935 RME1 Saccharomyces cerevisiae Rme1p NP_011558.1 582994 R 4932 CDS NP_011560.1 6321483 852937 584899..586056 1 NC_001139.8 Tam41p; Mitochondrial protein involved in protein import into the mitochondrial matrix; maintains the functional integrity of the TIM23 protein translocator complex; viability of null mutant is strain-dependent; mRNA is targeted to the bud 586056 TAM41 852937 TAM41 Saccharomyces cerevisiae Mitochondrial protein involved in protein import into the mitochondrial matrix; maintains the functional integrity of the TIM23 protein translocator complex; viability of null mutant is strain-dependent; mRNA is targeted to the bud NP_011560.1 584899 D 4932 CDS NP_011561.1 6321484 852938 complement(586396..589473) 1 NC_001139.8 Tfc4p; One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102 589473 TFC4 852938 TFC4 Saccharomyces cerevisiae One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102 NP_011561.1 586396 R 4932 CDS NP_011562.1 6321485 852939 589830..590915 1 NC_001139.8 Ufd1p; Protein that interacts with Cdc48p and Npl4p, involved in recognition of polyubiquitinated proteins and their presentation to the 26S proteasome for degradation; involved in transporting proteins from the ER to the cytosol 590915 UFD1 852939 UFD1 Saccharomyces cerevisiae Protein that interacts with Cdc48p and Npl4p, involved in recognition of polyubiquitinated proteins and their presentation to the 26S proteasome for degradation; involved in transporting proteins from the ER to the cytosol NP_011562.1 589830 D 4932 CDS NP_011563.1 6321486 852940 591318..591881 1 NC_001139.8 Scm4p; Potential regulatory effector of CDC4 function, suppresses a temperature-sensitive allele of CDC4, tripartite protein structure in which a charged region separates two uncharged domains, not essential for mitosis or meiosis 591881 SCM4 852940 SCM4 Saccharomyces cerevisiae Potential regulatory effector of CDC4 function, suppresses a temperature-sensitive allele of CDC4, tripartite protein structure in which a charged region separates two uncharged domains, not essential for mitosis or meiosis NP_011563.1 591318 D 4932 CDS NP_011566.1 6321489 852943 593600..594709 1 NC_001139.8 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Fmp48p 594709 FMP48 852943 FMP48 Saccharomyces cerevisiae Fmp48p NP_011566.1 593600 D 4932 CDS NP_011567.1 6321490 852944 complement(594990..595841) 1 NC_001139.8 Ygr053cp; Putative protein of unknown function 595841 852944 YGR053C Saccharomyces cerevisiae Putative protein of unknown function NP_011567.1 594990 R 4932 CDS NP_011568.1 6321491 852945 596697..598625 1 NC_001139.8 Ygr054wp; Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A 598625 852945 YGR054W Saccharomyces cerevisiae Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A NP_011568.1 596697 D 4932 CDS NP_011569.1 6321492 852946 599421..601145 1 NC_001139.8 Mup1p; High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake 601145 MUP1 852946 MUP1 Saccharomyces cerevisiae High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake NP_011569.1 599421 D 4932 CDS NP_011570.1 6321493 852947 601665..604451 1 NC_001139.8 Rsc1p; Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook 604451 RSC1 852947 RSC1 Saccharomyces cerevisiae Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook NP_011570.1 601665 D 4932 CDS NP_011571.2 37362653 852948 complement(604777..605505) 1 NC_001139.8 Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface; Lst7p 605505 LST7 852948 LST7 Saccharomyces cerevisiae Lst7p NP_011571.2 604777 R 4932 CDS NP_011572.1 6321495 852949 606140..607147 1 NC_001139.8 Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; Pef1p 607147 PEF1 852949 PEF1 Saccharomyces cerevisiae Pef1p NP_011572.1 606140 D 4932 CDS NP_011573.1 6321496 852950 607567..609105 1 NC_001139.8 Spr3p; Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI 609105 SPR3 852950 SPR3 Saccharomyces cerevisiae Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI NP_011573.1 607567 D 4932 CDS NP_011574.1 6321497 852951 610568..611497 1 NC_001139.8 Erg25p; C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol 611497 ERG25 852951 ERG25 Saccharomyces cerevisiae C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol NP_011574.1 610568 D 4932 CDS NP_011575.1 6321498 852952 complement(611893..615969) 1 NC_001139.8 Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; Ade6p 615969 ADE6 852952 ADE6 Saccharomyces cerevisiae Ade6p NP_011575.1 611893 R 4932 CDS NP_011576.1 6321499 852953 complement(616332..617282) 1 NC_001139.8 Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC; Cox18p 617282 COX18 852953 COX18 Saccharomyces cerevisiae Cox18p NP_011576.1 616332 R 4932 CDS NP_011577.1 6321501 852955 complement(617520..617828) 1 NC_001139.8 Spt4p; Protein that forms a complex with Spt5p and mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing; in addition, Spt4p is involved in kinetochore function and gene silencing 617828 SPT4 852955 SPT4 Saccharomyces cerevisiae Protein that forms a complex with Spt5p and mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing; in addition, Spt4p is involved in kinetochore function and gene silencing NP_011577.1 617520 R 4932 CDS NP_011579.1 6321502 852956 complement(618081..619862) 1 NC_001139.8 Vht1p; High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin 619862 VHT1 852956 VHT1 Saccharomyces cerevisiae High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin NP_011579.1 618081 R 4932 CDS NP_011580.1 6321503 852957 complement(620925..621803) 1 NC_001139.8 Ygr066cp; Putative protein of unknown function 621803 852957 YGR066C Saccharomyces cerevisiae Putative protein of unknown function NP_011580.1 620925 R 4932 CDS NP_011581.1 6321504 852958 complement(622406..624790) 1 NC_001139.8 Ygr067cp; Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p 624790 852958 YGR067C Saccharomyces cerevisiae Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p NP_011581.1 622406 R 4932 CDS NP_011582.1 6321506 852960 complement(625328..627088) 1 NC_001139.8 Ygr068cp; Putative protein of unknown function; YGR068C is not an essential gene. 627088 852960 YGR068C Saccharomyces cerevisiae Putative protein of unknown function; YGR068C is not an essential gene. NP_011582.1 625328 R 4932 CDS NP_011584.1 6321507 852961 627810..631277 1 NC_001139.8 Rom1p; GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP 631277 ROM1 852961 ROM1 Saccharomyces cerevisiae GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP NP_011584.1 627810 D 4932 CDS NP_011585.1 6321508 852962 complement(631485..634067) 1 NC_001139.8 Ygr071cp; Putative protein of unknown function; deletion mutant has increased glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the nucleus 634067 852962 YGR071C Saccharomyces cerevisiae Putative protein of unknown function; deletion mutant has increased glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the nucleus NP_011585.1 631485 R 4932 CDS NP_011586.1 6321509 852963 634308..635471 1 NC_001139.8 Upf3p; Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance 635471 UPF3 852963 UPF3 Saccharomyces cerevisiae Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance NP_011586.1 634308 D 4932 CDS NP_011588.1 6321510 852964 635716..636156 1 NC_001139.8 Smd1p; Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D1 636156 SMD1 852964 SMD1 Saccharomyces cerevisiae Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D1 NP_011588.1 635716 D 4932 CDS NP_011589.1 6321512 852966 complement(636151..636879) 1 NC_001139.8 Unique component of the U4/U6.U5 tri-snRNP particle, required for conformational changes which result in the catalytic activation of the spliceosome; dispensible for spliceosome assembly; Prp38p 636879 PRP38 852966 PRP38 Saccharomyces cerevisiae Prp38p NP_011589.1 636151 R 4932 CDS NP_011590.1 6321513 852967 complement(637108..637581) 1 NC_001139.8 Mrpl25p; Mitochondrial ribosomal protein of the large subunit 637581 MRPL25 852967 MRPL25 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit NP_011590.1 637108 R 4932 CDS NP_011591.1 6321514 852968 complement(637748..639517) 1 NC_001139.8 Pex8p; Intraperoxisomal organizer of the peroxisomal import machinery, tightly associated with the lumenal face of the peroxisomal membrane, essential for peroxisome biogenesis, binds PTS1-signal receptor Pex5p 639517 PEX8 852968 PEX8 Saccharomyces cerevisiae Intraperoxisomal organizer of the peroxisomal import machinery, tightly associated with the lumenal face of the peroxisomal membrane, essential for peroxisome biogenesis, binds PTS1-signal receptor Pex5p NP_011591.1 637748 R 4932 CDS NP_011592.1 6321515 852969 complement(639776..640375) 1 NC_001139.8 Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding; Pac10p 640375 PAC10 852969 PAC10 Saccharomyces cerevisiae Pac10p NP_011592.1 639776 R 4932 CDS NP_011593.1 6321516 852970 640724..641836 1 NC_001139.8 Ygr079wp; Putative protein of unknown function; YGR079W is not an essential gene 641836 852970 YGR079W Saccharomyces cerevisiae Putative protein of unknown function; YGR079W is not an essential gene NP_011593.1 640724 D 4932 CDS NP_011594.1 6321517 852971 642014..643012 1 NC_001139.8 Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly; Twf1p 643012 TWF1 852971 TWF1 Saccharomyces cerevisiae Twf1p NP_011594.1 642014 D 4932 CDS NP_011595.1 6321518 852972 complement(643152..643784) 1 NC_001139.8 Slx9p; Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant 643784 SLX9 852972 SLX9 Saccharomyces cerevisiae Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant NP_011595.1 643152 R 4932 CDS NP_011596.1 6321519 852973 644048..644599 1 NC_001139.8 Tom20p; Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins 644599 TOM20 852973 TOM20 Saccharomyces cerevisiae Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins NP_011596.1 644048 D 4932 CDS NP_011597.1 6321520 852974 complement(644864..646819) 1 NC_001139.8 Gcd2p; Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression 646819 GCD2 852974 GCD2 Saccharomyces cerevisiae Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression NP_011597.1 644864 R 4932 CDS NP_011598.1 6321521 852975 complement(647127..648146) 1 NC_001139.8 Mrp13p; Mitochondrial ribosomal protein of the small subunit 648146 MRP13 852975 MRP13 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the small subunit NP_011598.1 647127 R 4932 CDS NP_011599.1 6321522 852976 complement(648387..648911) 1 NC_001139.8 Rpl11bp; Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11 648911 RPL11B 852976 RPL11B Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11 NP_011599.1 648387 R 4932 CDS NP_011600.1 6321523 852977 complement(649602..650621) 1 NC_001139.8 Primary component of eisosomes, which are large immobile cell cortex structures associated with endocytosis; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria; Pil1p 650621 PIL1 852977 PIL1 Saccharomyces cerevisiae Pil1p NP_011600.1 649602 R 4932 CDS NP_011601.1 6321524 852978 complement(651294..652985) 1 NC_001139.8 Pdc6p; Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation 652985 PDC6 852978 PDC6 Saccharomyces cerevisiae Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation NP_011601.1 651294 R 4932 CDS NP_011602.2 86559466 852979 654638..656326 1 NC_001139.8 Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide; Ctt1p 656326 CTT1 852979 CTT1 Saccharomyces cerevisiae Ctt1p NP_011602.2 654638 D 4932 CDS NP_011603.1 6321526 852980 656964..659774 1 NC_001139.8 Protein that exhibits physical and genetic interactions with Rpb8p, which is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation; Nnf2p 659774 NNF2 852980 NNF2 Saccharomyces cerevisiae Nnf2p NP_011603.1 656964 D 4932 CDS NP_011604.1 6321527 852982 662362..666075 1 NC_001139.8 Utp22p; Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data 666075 UTP22 852982 UTP22 Saccharomyces cerevisiae Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data NP_011604.1 662362 D 4932 CDS NP_011605.1 6321528 852983 666345..667829 1 NC_001139.8 Splicing factor, component of the U4/U6-U5 snRNP complex; Prp31p 667829 PRP31 852983 PRP31 Saccharomyces cerevisiae Prp31p NP_011605.1 666345 D 4932 CDS NP_011606.1 6321529 852984 668193..669911 1 NC_001139.8 Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; Dbf2p 669911 DBF2 852984 DBF2 Saccharomyces cerevisiae Dbf2p NP_011606.1 668193 D 4932 CDS NP_011607.1 6321530 852985 670392..671915 1 NC_001139.8 Putative debranching enzyme associated ribonuclease; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; Drn1p 671915 DRN1 852985 DRN1 Saccharomyces cerevisiae Drn1p NP_011607.1 670392 D 4932 CDS NP_011608.1 6321531 852986 672190..675504 1 NC_001139.8 Vas1p; Mitochondrial and cytoplasmic valyl-tRNA synthetase 675504 VAS1 852986 VAS1 Saccharomyces cerevisiae Mitochondrial and cytoplasmic valyl-tRNA synthetase NP_011608.1 672190 D 4932 CDS NP_011609.2 37362654 852987 complement(675675..676346) 1 NC_001139.8 Rrp46p; Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex 676346 RRP46 852987 RRP46 Saccharomyces cerevisiae Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex NP_011609.2 675675 R 4932 CDS NP_011610.1 6321533 852988 676625..677569 1 NC_001139.8 Tpc1p; Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family 677569 TPC1 852988 TPC1 Saccharomyces cerevisiae Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family NP_011610.1 676625 D 4932 CDS NP_011611.1 6321534 852989 678699..682139 1 NC_001139.8 Component of the RNA polymerase II holoenzyme, phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p, which relieves repression of stress-response genes; Ask10p 682139 ASK10 852989 ASK10 Saccharomyces cerevisiae Ask10p NP_011611.1 678699 D 4932 CDS NP_011612.1 6321535 852990 complement(682570..687462) 1 NC_001139.8 Separase, a caspase-like cysteine protease that promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p; Esp1p 687462 ESP1 852990 ESP1 Saccharomyces cerevisiae Esp1p NP_011612.1 682570 R 4932 CDS NP_011613.1 6321536 852991 687903..689969 1 NC_001139.8 Tel2p; Essential DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect 689969 TEL2 852991 TEL2 Saccharomyces cerevisiae Essential DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect NP_011613.1 687903 D 4932 CDS NP_011614.1 6321537 852992 690249..693101 1 NC_001139.8 Mdr1p; Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function 693101 MDR1 852992 MDR1 Saccharomyces cerevisiae Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function NP_011614.1 690249 D 4932 CDS NP_011615.1 6321538 852993 693367..694407 1 NC_001139.8 Pcp1p; Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases 694407 PCP1 852993 PCP1 Saccharomyces cerevisiae Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases NP_011615.1 693367 D 4932 CDS NP_011616.1 6321539 852994 complement(694588..695139) 1 NC_001139.8 Ygr102cp; Putative protein of unknown function; transposon insertion mutant is salt sensitive and deletion mutant has growth defects; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 695139 852994 YGR102C Saccharomyces cerevisiae Putative protein of unknown function; transposon insertion mutant is salt sensitive and deletion mutant has growth defects; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_011616.1 694588 R 4932 CDS NP_011617.1 6321540 852995 695421..697238 1 NC_001139.8 Nucleolar protein involved in rRNA processing and 60S ribosomal subunit biogenesis; constituent of several different pre-ribosomal particles; required for exit from G0 and the initiation of cell proliferation; Nop7p 697238 NOP7 852995 NOP7 Saccharomyces cerevisiae Nop7p NP_011617.1 695421 D 4932 CDS NP_011618.1 6321541 852996 complement(697449..698372) 1 NC_001139.8 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in telomere maintenance; Srb5p 698372 SRB5 852996 SRB5 Saccharomyces cerevisiae Srb5p NP_011618.1 697449 R 4932 CDS NP_011619.1 6321542 852997 698603..698836 1 NC_001139.8 Vma21p; Integral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER) 698836 VMA21 852997 VMA21 Saccharomyces cerevisiae Integral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER) NP_011619.1 698603 D 4932 CDS NP_011620.1 6321543 852998 complement(698993..699790) 1 NC_001139.8 Ygr106cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar memebrane 699790 852998 YGR106C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar memebrane NP_011620.1 698993 R 4932 CDS NP_011622.1 6321545 853002 703640..705055 1 NC_001139.8 Clb1p; B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome 705055 CLB1 853002 CLB1 Saccharomyces cerevisiae B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome NP_011622.1 703640 D 4932 CDS NP_011623.1 6321546 853003 complement(705363..706505) 1 NC_001139.8 Clb6p; B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 706505 CLB6 853003 CLB6 Saccharomyces cerevisiae B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 NP_011623.1 705363 R 4932 CDS NP_011624.1 6321547 853006 join(707614..708463,708465..712258) 1 NC_001139.8 Ygr109w-bp; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 712258 853006 YGR109W-B Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_011624.1 707614 D 4932 CDS NP_058162.1 7839174 853005 707614..708486 1 NC_001139.8 Ygr109w-ap; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 708486 853005 YGR109W-A Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_058162.1 707614 D 4932 CDS NP_011625.1 6321548 853007 713713..715050 1 NC_001139.8 Ygr110wp; Putative protein of unknown function; transcription is increased in response to genotoxic stress 715050 853007 YGR110W Saccharomyces cerevisiae Putative protein of unknown function; transcription is increased in response to genotoxic stress NP_011625.1 713713 D 4932 CDS NP_011626.1 6321549 853008 715832..717034 1 NC_001139.8 Ygr111wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus 717034 853008 YGR111W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus NP_011626.1 715832 D 4932 CDS NP_011627.1 6321550 853009 717362..718531 1 NC_001139.8 Shy1p; Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome 718531 SHY1 853009 SHY1 Saccharomyces cerevisiae Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome NP_011627.1 717362 D 4932 CDS NP_011628.2 14318436 853010 718897..719928 1 NC_001139.8 Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments; Dam1p 719928 DAM1 853010 DAM1 Saccharomyces cerevisiae Dam1p NP_011628.2 718897 D 4932 CDS NP_011631.1 6321552 853011 720413..724768 1 NC_001139.8 Spt6p; Essential protein that interacts with histones and is involved in nucleosome disassembly and reassembly during transcription elongation 724768 SPT6 853011 SPT6 Saccharomyces cerevisiae Essential protein that interacts with histones and is involved in nucleosome disassembly and reassembly during transcription elongation NP_011631.1 720413 D 4932 CDS NP_011632.1 6321555 853014 complement(725053..726483) 1 NC_001139.8 Ygr117cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 726483 853014 YGR117C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm NP_011632.1 725053 R 4932 CDS NP_011633.1 6321556 853015 join(726978..727042,727363..727735) 1 NC_001139.8 Rps23ap; Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; nearly identical to Rps23Bp and similar to E. coli S12 and rat S23 ribosomal proteins; deletion of both RPS23A and RPS23B is lethal 727735 RPS23A 853015 RPS23A Saccharomyces cerevisiae Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; nearly identical to Rps23Bp and similar to E. coli S12 and rat S23 ribosomal proteins; deletion of both RPS23A and RPS23B is lethal NP_011633.1 726978 D 4932 CDS NP_011634.1 6321557 853016 complement(728051..729676) 1 NC_001139.8 Nup57p; Nucleoporin, essential subunit of the nuclear pore complex (NPC), functions as the organizing center of an NPC subcomplex containing Nsp1p, Nup49p, Nup57p, and Nic96p 729676 NUP57 853016 NUP57 Saccharomyces cerevisiae Nucleoporin, essential subunit of the nuclear pore complex (NPC), functions as the organizing center of an NPC subcomplex containing Nsp1p, Nup49p, Nup57p, and Nic96p NP_011634.1 728051 R 4932 CDS NP_011635.2 37362655 853017 complement(730038..730826) 1 NC_001139.8 Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; Cog2p 730826 COG2 853017 COG2 Saccharomyces cerevisiae Cog2p NP_011635.2 730038 R 4932 CDS NP_011636.1 6321559 853019 complement(731454..732932) 1 NC_001139.8 Mep1p; Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation 732932 MEP1 853019 MEP1 Saccharomyces cerevisiae Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation NP_011636.1 731454 R 4932 CDS NP_878078.1 33438796 1466458 733417..733632 1 NC_001139.8 Ygr121w-ap; Putative protein of unknown function 733632 1466458 YGR121W-A Saccharomyces cerevisiae Putative protein of unknown function NP_878078.1 733417 D 4932 CDS NP_011637.1 6321560 853020 733940..735148 1 NC_001139.8 Ygr122wp; Putative protein of unknown function; deletion mutants do not properly process Rim101p and have decreased resistance to rapamycin; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 735148 853020 YGR122W Saccharomyces cerevisiae Putative protein of unknown function; deletion mutants do not properly process Rim101p and have decreased resistance to rapamycin; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm NP_011637.1 733940 D 4932 CDS NP_011639.1 6321562 853023 complement(736667..738208) 1 NC_001139.8 Protein serine/threonine phosphatase with similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth; computational analyses suggest roles in phosphate metabolism and rRNA processing; Ppt1p 738208 PPT1 853023 PPT1 Saccharomyces cerevisiae Ppt1p NP_011639.1 736667 R 4932 CDS NP_011640.1 6321563 853025 739949..741667 1 NC_001139.8 Asparagine synthetase, isozyme of Asn1p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; Asn2p 741667 ASN2 853025 ASN2 Saccharomyces cerevisiae Asn2p NP_011640.1 739949 D 4932 CDS NP_011641.1 6321564 853026 742330..745440 1 NC_001139.8 Ygr125wp; Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole 745440 853026 YGR125W Saccharomyces cerevisiae Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole NP_011641.1 742330 D 4932 CDS NP_011642.1 6321565 853027 745840..746532 1 NC_001139.8 Ygr126wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS 746532 853027 YGR126W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS NP_011642.1 745840 D 4932 CDS NP_011643.1 6321566 853028 746803..747741 1 NC_001139.8 Ygr127wp; Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response 747741 853028 YGR127W Saccharomyces cerevisiae Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response NP_011643.1 746803 D 4932 CDS NP_011644.1 6321567 853029 complement(747955..750096) 1 NC_001139.8 Utp8p; Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA 750096 UTP8 853029 UTP8 Saccharomyces cerevisiae Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA NP_011644.1 747955 R 4932 CDS NP_011645.1 6321568 853030 750405..751052 1 NC_001139.8 Syf2p; Component of the spliceosome complex involved in pre-mRNA splicing; involved in regulation of cell cycle progression 751052 SYF2 853030 SYF2 Saccharomyces cerevisiae Component of the spliceosome complex involved in pre-mRNA splicing; involved in regulation of cell cycle progression NP_011645.1 750405 D 4932 CDS NP_011646.1 6321569 853031 complement(751399..753849) 1 NC_001139.8 Ygr130cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7) 753849 853031 YGR130C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7) NP_011646.1 751399 R 4932 CDS NP_011647.1 6321570 853032 754731..755255 1 NC_001139.8 Ygr131wp; Protein of unknown function; expression induced in response to ketoconazole; promoter region contains a sterol regulatory element motif, which has been identified as a Upc2p-binding site 755255 853032 YGR131W Saccharomyces cerevisiae Protein of unknown function; expression induced in response to ketoconazole; promoter region contains a sterol regulatory element motif, which has been identified as a Upc2p-binding site NP_011647.1 754731 D 4932 CDS NP_011648.1 6321571 853033 complement(755594..756457) 1 NC_001139.8 Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation; Phb1p 756457 PHB1 853033 PHB1 Saccharomyces cerevisiae Phb1p NP_011648.1 755594 R 4932 CDS NP_011649.1 6321572 853034 756901..757452 1 NC_001139.8 Pex4p; Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis 757452 PEX4 853034 PEX4 Saccharomyces cerevisiae Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis NP_011649.1 756901 D 4932 CDS NP_011650.1 6321573 853035 757775..761143 1 NC_001139.8 Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation; Caf130p 761143 CAF130 853035 CAF130 Saccharomyces cerevisiae Caf130p NP_011650.1 757775 D 4932 CDS NP_011651.1 6321574 853036 761397..762173 1 NC_001139.8 Pre9p; 20S proteasome beta-type subunit; the only nonessential 20S subunit 762173 PRE9 853036 PRE9 Saccharomyces cerevisiae 20S proteasome beta-type subunit; the only nonessential 20S subunit NP_011651.1 761397 D 4932 CDS NP_011652.1 6321575 853037 762433..763158 1 NC_001139.8 Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; Lsb1p 763158 LSB1 853037 LSB1 Saccharomyces cerevisiae Lsb1p NP_011652.1 762433 D 4932 CDS NP_011654.1 6321577 853039 complement(763767..765611) 1 NC_001139.8 Tpo2p; Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily 765611 TPO2 853039 TPO2 Saccharomyces cerevisiae Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily NP_011654.1 763767 R 4932 CDS NP_011656.1 6321579 853041 767434..770304 1 NC_001139.8 Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo; Cbf2p 770304 CBF2 853041 CBF2 Saccharomyces cerevisiae Cbf2p NP_011656.1 767434 D 4932 CDS NP_011657.1 6321580 853042 770574..771977 1 NC_001139.8 Vps62p; Vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins 771977 VPS62 853042 VPS62 Saccharomyces cerevisiae Vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins NP_011657.1 770574 D 4932 CDS NP_011658.1 6321581 853043 772459..773691 1 NC_001139.8 v-SNARE binding protein that facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase; Btn2p 773691 BTN2 853043 BTN2 Saccharomyces cerevisiae Btn2p NP_011658.1 772459 D 4932 CDS NP_011659.1 6321582 853045 775198..777513 1 NC_001139.8 Skn1p; Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p 777513 SKN1 853045 SKN1 Saccharomyces cerevisiae Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p NP_011659.1 775198 D 4932 CDS NP_011660.1 6321583 853047 780404..781384 1 NC_001139.8 Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability; Thi4p 781384 THI4 853047 THI4 Saccharomyces cerevisiae Thi4p NP_011660.1 780404 D 4932 CDS NP_011661.1 6321584 853048 781772..783895 1 NC_001139.8 Essential nucleolar protein of unknown function; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p; Enp2p 783895 ENP2 853048 ENP2 Saccharomyces cerevisiae Enp2p NP_011661.1 781772 D 4932 CDS NP_011662.1 6321585 853049 complement(784228..784863) 1 NC_001139.8 Ygr146cp; Putative protein of unknown function; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of a temperature sensitive hsf1 mutant 784863 853049 YGR146C Saccharomyces cerevisiae Putative protein of unknown function; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of a temperature sensitive hsf1 mutant NP_011662.1 784228 R 4932 CDS NP_878079.1 33438797 1466459 complement(785281..785442) 1 NC_001139.8 Ygr146c-ap; Putative protein of unknown function 785442 1466459 YGR146C-A Saccharomyces cerevisiae Putative protein of unknown function NP_878079.1 785281 R 4932 CDS NP_011663.1 6321586 853050 complement(786059..786925) 1 NC_001139.8 Nat2p; N alpha-acetyl-transferase, transfers acetyl group from acetyl coenzyme A to the N-terminal methionine residues of proteins 786925 NAT2 853050 NAT2 Saccharomyces cerevisiae N alpha-acetyl-transferase, transfers acetyl group from acetyl coenzyme A to the N-terminal methionine residues of proteins NP_011663.1 786059 R 4932 CDS NP_011664.1 6321587 853051 complement(787317..787784) 1 NC_001139.8 Rpl24bp; Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Ap and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate 787784 RPL24B 853051 RPL24B Saccharomyces cerevisiae Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Ap and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate NP_011664.1 787317 R 4932 CDS NP_011665.1 6321588 853052 789036..790334 1 NC_001139.8 Ygr149wp; Putative protein of unknown function; predicted to be an integal membrane protein 790334 853052 YGR149W Saccharomyces cerevisiae Putative protein of unknown function; predicted to be an integal membrane protein NP_011665.1 789036 D 4932 CDS NP_011666.1 6321589 853053 complement(790464..793058) 1 NC_001139.8 Protein of unknown function, contains PPR motifs; mutant has growth defects on both non-fermentable carbon sources and rich medium; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Dmr1p 793058 DMR1 853053 DMR1 Saccharomyces cerevisiae Dmr1p NP_011666.1 790464 R 4932 CDS NP_011668.1 6321591 853056 complement(794679..795497) 1 NC_001139.8 Rsr1p; GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases 795497 RSR1 853056 RSR1 Saccharomyces cerevisiae GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases NP_011668.1 794679 R 4932 CDS NP_011669.1 6321592 853057 796097..796750 1 NC_001139.8 Ygr153wp; Putative protein of unknown function 796750 853057 YGR153W Saccharomyces cerevisiae Putative protein of unknown function NP_011669.1 796097 D 4932 CDS NP_011670.1 6321593 853058 complement(796803..797873) 1 NC_001139.8 Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization; Gto1p 797873 GTO1 853058 GTO1 Saccharomyces cerevisiae Gto1p NP_011670.1 796803 R 4932 CDS NP_011671.1 6321594 853059 798548..800071 1 NC_001139.8 Cystathionine beta-synthase, catalyzes the synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; Cys4p 800071 CYS4 853059 CYS4 Saccharomyces cerevisiae Cys4p NP_011671.1 798548 D 4932 CDS NP_011672.1 6321595 853060 800551..801828 1 NC_001139.8 Pti1p; Pta1p Interacting protein 801828 PTI1 853060 PTI1 Saccharomyces cerevisiae Pta1p Interacting protein NP_011672.1 800551 D 4932 CDS NP_011673.1 6321596 853061 802445..805054 1 NC_001139.8 Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis; Cho2p 805054 CHO2 853061 CHO2 Saccharomyces cerevisiae Cho2p NP_011673.1 802445 D 4932 CDS NP_011674.1 6321597 853062 complement(805274..806026) 1 NC_001139.8 Mtr3p; 3'5' exoribonuclease, exosome subunit; nucleolar protein involved in export of mRNA and ribosomal subunits; homologous to the E. coli exonuclease RNase PH 806026 MTR3 853062 MTR3 Saccharomyces cerevisiae 3'5' exoribonuclease, exosome subunit; nucleolar protein involved in export of mRNA and ribosomal subunits; homologous to the E. coli exonuclease RNase PH NP_011674.1 805274 R 4932 CDS NP_011675.1 6321599 853064 complement(806417..807661) 1 NC_001139.8 Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis; Nsr1p 807661 NSR1 853064 NSR1 Saccharomyces cerevisiae Nsr1p NP_011675.1 806417 R 4932 CDS NP_011677.1 6321600 853065 complement(808634..809425) 1 NC_001139.8 Rts3p; Putative component of the protein phosphatase type 2A complex 809425 RTS3 853065 RTS3 Saccharomyces cerevisiae Putative component of the protein phosphatase type 2A complex NP_011677.1 808634 R 4932 CDS NP_001018033.1 63148620 3077355 810232..810510 1 NC_001139.8 Ygr161w-cp; Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species 810510 3077355 YGR161W-C Saccharomyces cerevisiae Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species NP_001018033.1 810232 D 4932 CDS NP_058163.1 7839176 853067 join(811743..813035,813037..817056) 1 NC_001139.8 Ygr161w-bp; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 817056 853067 YGR161W-B Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_058163.1 811743 D 4932 CDS NP_058164.1 7839175 853066 811743..813059 1 NC_001139.8 Ygr161w-ap; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 813059 853066 YGR161W-A Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_058164.1 811743 D 4932 CDS NP_058165.1 7839178 853068 complement(join(817752..821714,821716..823020)) 1 NC_001139.8 Ygr161c-dp; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 823020 853068 YGR161C-D Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_058165.1 817752 R 4932 CDS NP_058166.1 7839177 853069 complement(821698..823020) 1 NC_001139.8 Ygr161c-cp; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 823020 853069 YGR161C-C Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_058166.1 821698 R 4932 CDS NP_011678.1 6321601 853071 824064..826922 1 NC_001139.8 Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); homologous to Tif4632p; Tif4631p 826922 TIF4631 853071 TIF4631 Saccharomyces cerevisiae Tif4631p NP_011678.1 824064 D 4932 CDS NP_011679.1 6321602 853072 827557..828582 1 NC_001139.8 Gtr2p; Cytoplasmic GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; subunit of EGO complex, which is involved in microautophagy regulation, and of GSE complex, required for sorting of Gap1p; homolog of human RagC and RagD 828582 GTR2 853072 GTR2 Saccharomyces cerevisiae Cytoplasmic GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; subunit of EGO complex, which is involved in microautophagy regulation, and of GSE complex, required for sorting of Gap1p; homolog of human RagC and RagD NP_011679.1 827557 D 4932 CDS NP_011681.1 6321604 853075 829121..830158 1 NC_001139.8 Mrps35p; Mitochondrial ribosomal protein of the small subunit 830158 MRPS35 853075 MRPS35 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the small subunit NP_011681.1 829121 D 4932 CDS NP_011682.1 6321605 853076 830520..832202 1 NC_001139.8 Protein involved in biosynthesis of cell wall beta-glucans; subunit of the TRAPP (transport protein particle) complex, which is involved in the late steps of endoplasmic reticulum to Golgi transport; Kre11p 832202 KRE11 853076 KRE11 Saccharomyces cerevisiae Kre11p NP_011682.1 830520 D 4932 CDS NP_011683.1 6321606 853077 832461..833162 1 NC_001139.8 Clc1p; Clathrin light chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function, two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component 833162 CLC1 853077 CLC1 Saccharomyces cerevisiae Clathrin light chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function, two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component NP_011683.1 832461 D 4932 CDS NP_011684.1 6321607 853078 complement(833357..834487) 1 NC_001139.8 Ygr168cp; Putative protein of unknown function; YGR168C is not an essential gene 834487 853078 YGR168C Saccharomyces cerevisiae Putative protein of unknown function; YGR168C is not an essential gene NP_011684.1 833357 R 4932 CDS NP_011685.1 6321608 853079 complement(834694..835908) 1 NC_001139.8 Pus6p; Pseudouridine synthase responsible for modification of cytoplasmic and mitochondrial tRNAs at position 31; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability 835908 PUS6 853079 PUS6 Saccharomyces cerevisiae Pseudouridine synthase responsible for modification of cytoplasmic and mitochondrial tRNAs at position 31; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability NP_011685.1 834694 R 4932 CDS NP_878080.1 33438798 1466460 complement(836392..836670) 1 NC_001139.8 Ygr169c-ap; Putative protein of unknown function 836670 1466460 YGR169C-A Saccharomyces cerevisiae Putative protein of unknown function NP_878080.1 836392 R 4932 CDS NP_011686.1 6321609 853080 837147..840563 1 NC_001139.8 Psd2p; Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine 840563 PSD2 853080 PSD2 Saccharomyces cerevisiae Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine NP_011686.1 837147 D 4932 CDS NP_011687.1 6321610 853081 complement(840829..842556) 1 NC_001139.8 Msm1p; Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p 842556 MSM1 853081 MSM1 Saccharomyces cerevisiae Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p NP_011687.1 840829 R 4932 CDS NP_011688.1 6321611 853082 complement(842850..843596) 1 NC_001139.8 Yip1p; Integral membrane protein required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles 843596 YIP1 853082 YIP1 Saccharomyces cerevisiae Integral membrane protein required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles NP_011688.1 842850 R 4932 CDS NP_011689.1 6321612 853083 843859..844965 1 NC_001139.8 Rbg2p; Protein with similarity to mammalian developmentally regulated GTP-binding protein 844965 RBG2 853083 RBG2 Saccharomyces cerevisiae Protein with similarity to mammalian developmentally regulated GTP-binding protein NP_011689.1 843859 D 4932 CDS NP_011690.1 6321613 853085 complement(845898..846410) 1 NC_001139.8 Mitochondrial protein required for assembly of ubiquinol cytochrome-c reductase complex (cytochrome bc1 complex); interacts with Cbp3p and function is partially redundant with that of Cbp3p; Cbp4p 846410 CBP4 853085 CBP4 Saccharomyces cerevisiae Cbp4p NP_011690.1 845898 R 4932 CDS NP_878081.1 33438799 1466461 846660..846746 1 NC_001139.8 Ygr174w-ap; Putative protein of unknown function 846746 1466461 YGR174W-A Saccharomyces cerevisiae Putative protein of unknown function NP_878081.1 846660 D 4932 CDS NP_011691.1 6321614 853086 complement(846938..848428) 1 NC_001139.8 Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine; Erg1p 848428 ERG1 853086 ERG1 Saccharomyces cerevisiae Erg1p NP_011691.1 846938 R 4932 CDS NP_011693.1 6321616 853088 complement(848834..850441) 1 NC_001139.8 Atf2p; Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important in brewing 850441 ATF2 853088 ATF2 Saccharomyces cerevisiae Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important in brewing NP_011693.1 848834 R 4932 CDS NP_011694.1 6321617 853089 complement(851052..853220) 1 NC_001139.8 Protein interacting with poly(A)-binding protein Pab1p; likely involved in controlling the extent of mRNA polyadenylation; forms a complex with Mkt1p that may regulate HO translation; interacts with Lsm12p in a copurification assay; Pbp1p 853220 PBP1 853089 PBP1 Saccharomyces cerevisiae Pbp1p NP_011694.1 851052 R 4932 CDS NP_011695.1 6321618 853090 complement(853680..854900) 1 NC_001139.8 Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly; Okp1p 854900 OKP1 853090 OKP1 Saccharomyces cerevisiae Okp1p NP_011695.1 853680 R 4932 CDS NP_011696.1 6321619 853091 complement(855269..856306) 1 NC_001139.8 Rnr4p; Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits 856306 RNR4 853091 RNR4 Saccharomyces cerevisiae Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits NP_011696.1 855269 R 4932 CDS NP_011697.1 6321620 853093 858292..858609 1 NC_001139.8 Tim13p; Mitochondrial intermembrane space protein, forms a complex with TIm8p that mediates import and insertion of a subset of polytopic inner membrane proteins; may prevent aggregation of incoming proteins in a chaperone-like manner 858609 TIM13 853093 TIM13 Saccharomyces cerevisiae Mitochondrial intermembrane space protein, forms a complex with TIm8p that mediates import and insertion of a subset of polytopic inner membrane proteins; may prevent aggregation of incoming proteins in a chaperone-like manner NP_011697.1 858292 D 4932 CDS NP_011699.1 6321622 853095 complement(join(859068..859265,859479..859481)) 1 NC_001139.8 Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex; Qcr9p 859481 QCR9 853095 QCR9 Saccharomyces cerevisiae Qcr9p NP_011699.1 859068 R 4932 CDS NP_011700.1 6321623 853096 complement(859906..865758) 1 NC_001139.8 Ubr1p; Ubiquitin-protein ligase (E3) that interacts with Rad6p/Ubc2p to ubiquitinate substrates of the N-end rule pathway; binds to the Rpn2p, Rpt1p, and Rpt6p proteins of the 19S particle of the 26S proteasome 865758 UBR1 853096 UBR1 Saccharomyces cerevisiae Ubiquitin-protein ligase (E3) that interacts with Rad6p/Ubc2p to ubiquitinate substrates of the N-end rule pathway; binds to the Rpn2p, Rpt1p, and Rpt6p proteins of the 19S particle of the 26S proteasome NP_011700.1 859906 R 4932 CDS NP_011701.1 6321624 853097 complement(866341..867525) 1 NC_001139.8 Tys1p; Cytoplasmic tyrosyl-tRNA synthetase, class I aminoacyl-tRNA synthetase that aminoacylates tRNA(Tyr), required for cytoplasmic protein synthesis, interacts with positions 34 and 35 of the anticodon of tRNATyr 867525 TYS1 853097 TYS1 Saccharomyces cerevisiae Cytoplasmic tyrosyl-tRNA synthetase, class I aminoacyl-tRNA synthetase that aminoacylates tRNA(Tyr), required for cytoplasmic protein synthesis, interacts with positions 34 and 35 of the anticodon of tRNATyr NP_011701.1 866341 R 4932 CDS NP_011702.1 6321625 853098 867779..869986 1 NC_001139.8 Tfg1p; TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74 869986 TFG1 853098 TFG1 Saccharomyces cerevisiae TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74 NP_011702.1 867779 D 4932 CDS NP_011703.1 6321626 853099 complement(870237..871421) 1 NC_001139.8 Protein of unknown function with similarity to human HMG1 and HMG2; localizes to the cytoplasm; Hgh1p 871421 HGH1 853099 HGH1 Saccharomyces cerevisiae Hgh1p NP_011703.1 870237 R 4932 CDS NP_011704.1 6321627 853100 complement(872049..875114) 1 NC_001139.8 Protein kinase that forms a complex with Mad1p and Bub3p that is crucial in the checkpoint mechanism required to prevent cell cycle progression into anaphase in the presence of spindle damage, associates with centromere DNA via Skp1p; Bub1p 875114 BUB1 853100 BUB1 Saccharomyces cerevisiae Bub1p NP_011704.1 872049 R 4932 CDS NP_011705.1 6321628 853102 complement(876674..878197) 1 NC_001139.8 Crh1p; Cell wall protein that functions in the transfer of chitin to beta(1-6)glucan, putative chitin transglycosidase 878197 CRH1 853102 CRH1 Saccharomyces cerevisiae Cell wall protein that functions in the transfer of chitin to beta(1-6)glucan, putative chitin transglycosidase NP_011705.1 876674 R 4932 CDS NP_011707.1 6321629 853104 880425..882236 1 NC_001139.8 Hip1p; High-affinity histidine permease, also involved in the transport of manganese ions 882236 HIP1 853104 HIP1 Saccharomyces cerevisiae High-affinity histidine permease, also involved in the transport of manganese ions NP_011707.1 880425 D 4932 CDS NP_011708.1 6321631 853106 complement(882817..883815) 1 NC_001139.8 Tdh3p; Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall 883815 TDH3 853106 TDH3 Saccharomyces cerevisiae Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall NP_011708.1 882817 R 4932 CDS NP_011709.1 6321632 853107 complement(884514..885746) 1 NC_001139.8 Pdx1p; Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core 885746 PDX1 853107 PDX1 Saccharomyces cerevisiae Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core NP_011709.1 884514 R 4932 CDS NP_011710.1 6321633 853108 complement(886078..887880) 1 NC_001139.8 Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains; Xks1p 887880 XKS1 853108 XKS1 Saccharomyces cerevisiae Xks1p NP_011710.1 886078 R 4932 CDS NP_011711.1 6321634 853109 888887..889627 1 NC_001139.8 Ski6p; 3'-to-5' phosphorolytic exoribonuclease that is a subunit of the exosome; required for 3' processing of the 5.8S rRNA; involved in 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs 889627 SKI6 853109 SKI6 Saccharomyces cerevisiae 3'-to-5' phosphorolytic exoribonuclease that is a subunit of the exosome; required for 3' processing of the 5.8S rRNA; involved in 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs NP_011711.1 888887 D 4932 CDS NP_011712.1 6321635 853110 complement(889738..892191) 1 NC_001139.8 Protein of unknown function, required for survival upon exposure to K1 killer toxin; Fyv8p 892191 FYV8 853110 FYV8 Saccharomyces cerevisiae Fyv8p NP_011712.1 889738 R 4932 CDS NP_011713.1 6321636 853111 complement(892502..894145) 1 NC_001139.8 Sng1p; Protein involved in nitrosoguanidine (MNNG) resistance; expression is regulated by transcription factors involved in multidrug resistance 894145 SNG1 853111 SNG1 Saccharomyces cerevisiae Protein involved in nitrosoguanidine (MNNG) resistance; expression is regulated by transcription factors involved in multidrug resistance NP_011713.1 892502 R 4932 CDS NP_011714.1 6321637 853112 894698..897151 1 NC_001139.8 Ypp1p; Cargo-transport protein involved in endocytosis; may interact with ribosomes, based on co-purification experiments; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene 897151 YPP1 853112 YPP1 Saccharomyces cerevisiae Cargo-transport protein involved in endocytosis; may interact with ribosomes, based on co-purification experiments; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene NP_011714.1 894698 D 4932 CDS NP_011715.1 6321638 853113 897507..899786 1 NC_001139.8 Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases; Pmt6p 899786 PMT6 853113 PMT6 Saccharomyces cerevisiae Pmt6p NP_011715.1 897507 D 4932 CDS NP_011716.1 6321639 853114 complement(899909..902275) 1 NC_001139.8 Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin; Elp2p 902275 ELP2 853114 ELP2 Saccharomyces cerevisiae Elp2p NP_011716.1 899909 R 4932 CDS NP_011717.2 37362656 853115 complement(902525..903202) 1 NC_001139.8 Ygr201cp; Putative protein of unknown function 903202 853115 YGR201C Saccharomyces cerevisiae Putative protein of unknown function NP_011717.2 902525 R 4932 CDS NP_011718.1 6321641 853116 complement(903479..904753) 1 NC_001139.8 Pct1p; Cholinephosphate cytidylyltransferase, also known as CTP:phosphocholine cytidylyltransferase, rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding 904753 PCT1 853116 PCT1 Saccharomyces cerevisiae Cholinephosphate cytidylyltransferase, also known as CTP:phosphocholine cytidylyltransferase, rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding NP_011718.1 903479 R 4932 CDS NP_011719.1 6321642 853117 905242..905688 1 NC_001139.8 Ygr203wp; Putative protein with sequence similarity to protein tyrosine phosphatases of the CDC25-like phosphatase family; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus 905688 853117 YGR203W Saccharomyces cerevisiae Putative protein with sequence similarity to protein tyrosine phosphatases of the CDC25-like phosphatase family; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus NP_011719.1 905242 D 4932 CDS NP_011720.1 6321643 853118 905939..908779 1 NC_001139.8 Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; Ade3p 908779 ADE3 853118 ADE3 Saccharomyces cerevisiae Ade3p NP_011720.1 905939 D 4932 CDS NP_878082.1 33438800 1466462 complement(909066..909179) 1 NC_001139.8 Ygr204c-ap; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 909179 1466462 YGR204C-A Saccharomyces cerevisiae Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching NP_878082.1 909066 R 4932 CDS NP_011721.1 6321644 853119 909218..910090 1 NC_001139.8 Ygr205wp; ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases 910090 853119 YGR205W Saccharomyces cerevisiae ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases NP_011721.1 909218 D 4932 CDS NP_011722.1 6321645 853120 910437..910742 1 NC_001139.8 Mvb12p; ESCRT-I subunit necessary for the efficient transport of cargo proteins to the vacuolar lumen; deletion mutant sensitive to rapamycin and nystatin; green fluorescent protein (GFP)-fusion protein localizes to endosome 910742 MVB12 853120 MVB12 Saccharomyces cerevisiae ESCRT-I subunit necessary for the efficient transport of cargo proteins to the vacuolar lumen; deletion mutant sensitive to rapamycin and nystatin; green fluorescent protein (GFP)-fusion protein localizes to endosome NP_011722.1 910437 D 4932 CDS NP_011723.1 6321646 853121 complement(910848..911633) 1 NC_001139.8 Ygr207cp; Protein that interacts with frataxin (Yfh1p); putative homolog of mammalian electron transfer flavoprotein complex subunit ETF-beta; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 911633 853121 YGR207C Saccharomyces cerevisiae Protein that interacts with frataxin (Yfh1p); putative homolog of mammalian electron transfer flavoprotein complex subunit ETF-beta; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_011723.1 910848 R 4932 CDS NP_011724.1 6321647 853122 911888..912817 1 NC_001139.8 Ser2p; Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source 912817 SER2 853122 SER2 Saccharomyces cerevisiae Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source NP_011724.1 911888 D 4932 CDS NP_011725.1 6321648 853123 complement(912918..913232) 1 NC_001139.8 Trx2p; Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance 913232 TRX2 853123 TRX2 Saccharomyces cerevisiae Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance NP_011725.1 912918 R 4932 CDS NP_011726.1 6321649 853124 complement(913508..914743) 1 NC_001139.8 Ygr210cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 914743 853124 YGR210C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm NP_011726.1 913508 R 4932 CDS NP_011727.1 6321650 853125 915246..916706 1 NC_001139.8 Zpr1p; Essential protein with two zinc fingers, present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p; binds to translation elongation factor eEF-1 (Tef1p) 916706 ZPR1 853125 ZPR1 Saccharomyces cerevisiae Essential protein with two zinc fingers, present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p; binds to translation elongation factor eEF-1 (Tef1p) NP_011727.1 915246 D 4932 CDS NP_011728.1 6321651 853126 917045..918451 1 NC_001139.8 Sli1p; N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin 918451 SLI1 853126 SLI1 Saccharomyces cerevisiae N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin NP_011728.1 917045 D 4932 CDS NP_011729.1 6321652 853127 complement(918517..919470) 1 NC_001139.8 Rta1p; Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions 919470 RTA1 853127 RTA1 Saccharomyces cerevisiae Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions NP_011729.1 918517 R 4932 CDS NP_011730.1 6321653 853128 join(920580..920669,921125..921793) 1 NC_001139.8 Rps0ap; Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal 921793 RPS0A 853128 RPS0A Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal NP_011730.1 920580 D 4932 CDS NP_011731.1 6321654 853129 922180..922512 1 NC_001139.8 Rsm27p; Mitochondrial ribosomal protein of the small subunit 922512 RSM27 853129 RSM27 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the small subunit NP_011731.1 922180 D 4932 CDS NP_011732.1 6321655 853130 complement(922638..924467) 1 NC_001139.8 Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs; Gpi1p 924467 GPI1 853130 GPI1 Saccharomyces cerevisiae Gpi1p NP_011732.1 922638 R 4932 CDS NP_011733.1 6321656 853131 924699..930818 1 NC_001139.8 Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together; Cch1p 930818 CCH1 853131 CCH1 Saccharomyces cerevisiae Cch1p NP_011733.1 924699 D 4932 CDS NP_011734.1 6321657 853133 932544..935798 1 NC_001139.8 Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; Crm1p 935798 CRM1 853133 CRM1 Saccharomyces cerevisiae Crm1p NP_011734.1 932544 D 4932 CDS NP_011736.1 6321659 853135 complement(936077..936886) 1 NC_001139.8 Mrpl9p; Mitochondrial ribosomal protein of the large subunit 936886 MRPL9 853135 MRPL9 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit NP_011736.1 936077 R 4932 CDS NP_011737.1 6321660 853136 complement(937127..938995) 1 NC_001139.8 Tos2p; Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p 938995 TOS2 853136 TOS2 Saccharomyces cerevisiae Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p NP_011737.1 937127 R 4932 CDS NP_011738.1 6321661 853137 939926..940807 1 NC_001139.8 Pet54p; Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet122p and Pet494p; also required for splicing of the COX1 intron AI5 beta; located in the mitochondrial inner membrane 940807 PET54 853137 PET54 Saccharomyces cerevisiae Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet122p and Pet494p; also required for splicing of the COX1 intron AI5 beta; located in the mitochondrial inner membrane NP_011738.1 939926 D 4932 CDS NP_011739.1 6321662 853138 complement(940872..942218) 1 NC_001139.8 Phosphatidylinositol 3,5-bisphosphate-binding protein, predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization; Hsv2p 942218 HSV2 853138 HSV2 Saccharomyces cerevisiae Hsv2p NP_011739.1 940872 R 4932 CDS NP_011740.1 6321663 853139 942809..944650 1 NC_001139.8 Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole; Azr1p 944650 AZR1 853139 AZR1 Saccharomyces cerevisiae Azr1p NP_011740.1 942809 D 4932 CDS NP_011741.3 83578100 853140 join(945148..946330,946424..947022) 1 NC_001139.8 Ama1p; Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis 947022 AMA1 853140 AMA1 Saccharomyces cerevisiae Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis NP_011741.3 945148 D 4932 CDS NP_011743.1 6321666 853142 947423..949000 1 NC_001139.8 Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase of the ER, functions in the pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1; Die2p 949000 DIE2 853142 DIE2 Saccharomyces cerevisiae Die2p NP_011743.1 947423 D 4932 CDS NP_011745.1 6321668 853144 complement(949385..950902) 1 NC_001139.8 Smi1p; Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity 950902 SMI1 853144 SMI1 Saccharomyces cerevisiae Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity NP_011745.1 949385 R 4932 CDS NP_011746.1 6321669 853145 951897..952310 1 NC_001139.8 Protein with some similarity to Spo12p; overexpression bypasses need for Spo12p, but not required for meiosis; Bns1p 952310 BNS1 853145 BNS1 Saccharomyces cerevisiae Bns1p NP_011746.1 951897 D 4932 CDS NP_011747.2 50593217 853146 complement(952551..953483) 1 NC_001139.8 Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation; Phb2p 953483 PHB2 853146 PHB2 Saccharomyces cerevisiae Phb2p NP_011747.2 952551 R 4932 CDS NP_011748.1 6321671 853147 953963..954649 1 NC_001139.8 Regulatory, non-ATPase subunit of the 26S proteasome; homolog of the human oncoprotein gankyrin, which interacts with the retinoblastoma tumor suppressor (Rb) and cyclin-dependent kinase 4/6; Nas6p 954649 NAS6 853147 NAS6 Saccharomyces cerevisiae Nas6p NP_011748.1 953963 D 4932 CDS NP_011749.1 6321672 853148 complement(954677..958213) 1 NC_001139.8 Pho81p; Cyclin-dependent kinase (CDK) inhibitor, regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p 958213 PHO81 853148 PHO81 Saccharomyces cerevisiae Cyclin-dependent kinase (CDK) inhibitor, regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p NP_011749.1 954677 R 4932 CDS NP_011750.1 6321673 853149 959908..961107 1 NC_001139.8 Yhb1p; Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses 961107 YHB1 853149 YHB1 Saccharomyces cerevisiae Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses NP_011750.1 959908 D 4932 CDS NP_011751.1 6321674 853150 complement(961364..962065) 1 NC_001139.8 Ygr235cp; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 962065 853150 YGR235C Saccharomyces cerevisiae Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_011751.1 961364 R 4932 CDS NP_011752.2 82795251 853151 complement(962534..962821) 1 NC_001139.8 Spg1p; Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 962821 SPG1 853151 SPG1 Saccharomyces cerevisiae Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_011752.2 962534 R 4932 CDS NP_011753.1 6321676 853152 complement(963303..965660) 1 NC_001139.8 Ygr237cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 965660 853152 YGR237C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm NP_011753.1 963303 R 4932 CDS NP_011754.1 6321677 853153 complement(966044..968692) 1 NC_001139.8 Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate; Kel2p 968692 KEL2 853153 KEL2 Saccharomyces cerevisiae Kel2p NP_011754.1 966044 R 4932 CDS NP_011755.1 6321678 853154 complement(969192..970058) 1 NC_001139.8 Pex21p; Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex18p 970058 PEX21 853154 PEX21 Saccharomyces cerevisiae Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex18p NP_011755.1 969192 R 4932 CDS NP_011756.1 6321679 853155 complement(970776..973739) 1 NC_001139.8 Pfk1p; Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes 973739 PFK1 853155 PFK1 Saccharomyces cerevisiae Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes NP_011756.1 970776 R 4932 CDS NP_878083.1 33438801 1466463 complement(974582..974782) 1 NC_001139.8 Ygr240c-ap; Putative protein of unknown function; identified by fungal homology and RT-PCR 974782 1466463 YGR240C-A Saccharomyces cerevisiae Putative protein of unknown function; identified by fungal homology and RT-PCR NP_878083.1 974582 R 4932 CDS NP_011757.1 6321681 853157 complement(974880..976586) 1 NC_001139.8 Yap1802p; Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1801p, member of the AP180 protein family 976586 YAP1802 853157 YAP1802 Saccharomyces cerevisiae Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1801p, member of the AP180 protein family NP_011757.1 974880 R 4932 CDS NP_011759.1 6321682 853158 977341..977781 1 NC_001139.8 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Fmp43p 977781 FMP43 853158 FMP43 Saccharomyces cerevisiae Fmp43p NP_011759.1 977341 D 4932 CDS NP_011760.1 6321683 853159 complement(978041..979324) 1 NC_001139.8 Lsc2p; Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate 979324 LSC2 853159 LSC2 Saccharomyces cerevisiae Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate NP_011760.1 978041 R 4932 CDS NP_011761.1 6321684 853160 complement(979770..982073) 1 NC_001139.8 Sda1p; Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis 982073 SDA1 853160 SDA1 Saccharomyces cerevisiae Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis NP_011761.1 979770 R 4932 CDS NP_011762.1 6321685 853161 complement(982487..984277) 1 NC_001139.8 TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB; Brf1p 984277 BRF1 853161 BRF1 Saccharomyces cerevisiae Brf1p NP_011762.1 982487 R 4932 CDS NP_011763.1 6321686 853162 984971..985690 1 NC_001139.8 Cyclic nucleotide phosphodiesterase, hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression; Cpd1p 985690 CPD1 853162 CPD1 Saccharomyces cerevisiae Cpd1p NP_011763.1 984971 D 4932 CDS NP_011764.1 6321687 853163 985977..986744 1 NC_001139.8 Sol4p; 6-phosphogluconolactonase with similarity to Sol3p 986744 SOL4 853163 SOL4 Saccharomyces cerevisiae 6-phosphogluconolactonase with similarity to Sol3p NP_011764.1 985977 D 4932 CDS NP_011765.1 6321688 853164 988054..989424 1 NC_001139.8 Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants; Mga1p 989424 MGA1 853164 MGA1 Saccharomyces cerevisiae Mga1p NP_011765.1 988054 D 4932 CDS NP_011766.1 6321689 853165 complement(991181..993526) 1 NC_001139.8 Ygr250cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 993526 853165 YGR250C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm NP_011766.1 991181 R 4932 CDS NP_011767.1 6321690 853166 995644..996234 1 NC_001139.8 Ygr251wp; Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene 996234 853166 YGR251W Saccharomyces cerevisiae Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene NP_011767.1 995644 D 4932 CDS NP_011768.1 6321691 853167 996874..998193 1 NC_001139.8 Histone acetyltransferase, acetylates N-terminal lysines on histones H2B and H3; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; founding member of the Gcn5p-related N-acetyltransferase superfamily; Gcn5p 998193 GCN5 853167 GCN5 Saccharomyces cerevisiae Gcn5p NP_011768.1 996874 D 4932 CDS NP_011769.1 6321692 853168 complement(998363..999145) 1 NC_001139.8 Pup2p; Alpha subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta 999145 PUP2 853168 PUP2 Saccharomyces cerevisiae Alpha subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta NP_011769.1 998363 R 4932 CDS NP_011770.1 6321693 853169 1000932..1002245 1 NC_001139.8 Enolase I, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose; Eno1p 1002245 ENO1 853169 ENO1 Saccharomyces cerevisiae Eno1p NP_011770.1 1000932 D 4932 CDS NP_011771.1 6321694 853170 complement(1002528..1003967) 1 NC_001139.8 Putative flavin-dependent monooxygenase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; Coq6p 1003967 COQ6 853170 COQ6 Saccharomyces cerevisiae Coq6p NP_011771.1 1002528 R 4932 CDS NP_011772.1 6321695 853172 1004630..1006108 1 NC_001139.8 Gnd2p; 6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone 1006108 GND2 853172 GND2 Saccharomyces cerevisiae 6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone NP_011772.1 1004630 D 4932 CDS NP_011773.1 6321696 853173 complement(1006211..1007311) 1 NC_001139.8 Mtm1p; Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor 1007311 MTM1 853173 MTM1 Saccharomyces cerevisiae Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor NP_011773.1 1006211 R 4932 CDS NP_011774.1 6321697 853174 complement(1007677..1010772) 1 NC_001139.8 Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein; Rad2p 1010772 RAD2 853174 RAD2 Saccharomyces cerevisiae Rad2p NP_011774.1 1007677 R 4932 CDS NP_011776.1 6321698 853175 1012491..1014095 1 NC_001139.8 Tna1p; High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA) 1014095 TNA1 853175 TNA1 Saccharomyces cerevisiae High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA) NP_011776.1 1012491 D 4932 CDS NP_011777.1 6321700 853177 complement(1014327..1016756) 1 NC_001139.8 Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools; Apl6p 1016756 APL6 853177 APL6 Saccharomyces cerevisiae Apl6p NP_011777.1 1014327 R 4932 CDS NP_011778.1 6321701 853178 complement(1016980..1017765) 1 NC_001139.8 Protein kinase proposed to be involved in bud-site selection, telomere uncapping and elongation, and transcription; component of the EKC/KEOPS protein complex with Kae1p, Cgi121p, Pcc1p, and Gon7p; Bud32p 1017765 BUD32 853178 BUD32 Saccharomyces cerevisiae Bud32p NP_011778.1 1016980 R 4932 CDS NP_011779.1 6321702 853179 complement(1017973..1019247) 1 NC_001139.8 Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; Say1p 1019247 SAY1 853179 SAY1 Saccharomyces cerevisiae Say1p NP_011779.1 1017973 R 4932 CDS NP_011780.1 6321704 853181 complement(1019604..1021859) 1 NC_001139.8 Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs; Mes1p 1021859 MES1 853181 MES1 Saccharomyces cerevisiae Mes1p NP_011780.1 1019604 R 4932 CDS NP_011782.1 6321705 853182 1022662..1024767 1 NC_001139.8 Ygr266wp; Protein of unknown function, predicted to contain a single transmembrane domain; localized to both the mitochondrial outer membrane and the plasma membrane 1024767 853182 YGR266W Saccharomyces cerevisiae Protein of unknown function, predicted to contain a single transmembrane domain; localized to both the mitochondrial outer membrane and the plasma membrane NP_011782.1 1022662 D 4932 CDS NP_011783.1 6321706 853183 complement(1025010..1025741) 1 NC_001139.8 GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway; Fol2p 1025741 FOL2 853183 FOL2 Saccharomyces cerevisiae Fol2p NP_011783.1 1025010 R 4932 CDS NP_011784.1 6321708 853185 complement(1026063..1026659) 1 NC_001139.8 Hua1p; Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly 1026659 HUA1 853185 HUA1 Saccharomyces cerevisiae Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly NP_011784.1 1026063 R 4932 CDS NP_011786.1 6321709 853186 1027376..1031515 1 NC_001139.8 Yta7p; Protein of unknown function, member of CDC48/PAS1/SEC18 family of ATPases, potentially phosphorylated by Cdc28p 1031515 YTA7 853186 YTA7 Saccharomyces cerevisiae Protein of unknown function, member of CDC48/PAS1/SEC18 family of ATPases, potentially phosphorylated by Cdc28p NP_011786.1 1027376 D 4932 CDS NP_011787.1 6321710 853187 1031797..1037700 1 NC_001139.8 Slh1p; Putative RNA helicase related to Ski2p, involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses 1037700 SLH1 853187 SLH1 Saccharomyces cerevisiae Putative RNA helicase related to Ski2p, involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses NP_011787.1 1031797 D 4932 CDS NP_076891.2 162949220 853188 complement(1037806..1038507) 1 NC_001139.8 Protein of unknown function; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; Efg1p 1038507 EFG1 853188 EFG1 Saccharomyces cerevisiae Efg1p NP_076891.2 1037806 R 4932 CDS NP_011789.1 6321712 853190 complement(1038721..1039245) 1 NC_001139.8 Ygr273cp; Putative protein of unknown function; deletion mutant has no readily detectable phenotype 1039245 853190 YGR273C Saccharomyces cerevisiae Putative protein of unknown function; deletion mutant has no readily detectable phenotype NP_011789.1 1038721 R 4932 CDS NP_011790.1 6321713 853191 complement(1039902..1043102) 1 NC_001139.8 Taf1p; TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation, has histone acetyltransferase activity, involved in promoter binding and G1/S progression 1043102 TAF1 853191 TAF1 Saccharomyces cerevisiae TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation, has histone acetyltransferase activity, involved in promoter binding and G1/S progression NP_011790.1 1039902 R 4932 CDS NP_011791.2 37362657 853192 1043283..1043756 1 NC_001139.8 Rtt102p; Component of both the SWI/SNF and RSC chromatin remodeling complexes, suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition 1043756 RTT102 853192 RTT102 Saccharomyces cerevisiae Component of both the SWI/SNF and RSC chromatin remodeling complexes, suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition NP_011791.2 1043283 D 4932 CDS NP_011792.1 6321715 853193 complement(1043826..1045487) 1 NC_001139.8 Rnh70p; 3' exoribonuclease, required for 5S rRNA and tRNA-Arg3 maturation 1045487 RNH70 853193 RNH70 Saccharomyces cerevisiae 3' exoribonuclease, required for 5S rRNA and tRNA-Arg3 maturation NP_011792.1 1043826 R 4932 CDS NP_011793.1 6321716 853194 complement(1045651..1046568) 1 NC_001139.8 Ygr277cp; Putative pantetheine-phosphate adenylyltransferase (PPAT) that catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; conserved in bacteria, humans, and plants; essential for viability 1046568 853194 YGR277C Saccharomyces cerevisiae Putative pantetheine-phosphate adenylyltransferase (PPAT) that catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; conserved in bacteria, humans, and plants; essential for viability NP_011793.1 1045651 R 4932 CDS NP_011794.1 6321717 853195 1046738..1048471 1 NC_001139.8 Essential protein, component of a complex containing Cef1p, has similarity to S. pombe Cwf22p; putative spliceosomal component, based on computational analysis of large-scale protein-protein interaction data; Cwc22p 1048471 CWC22 853195 CWC22 Saccharomyces cerevisiae Cwc22p NP_011794.1 1046738 D 4932 CDS NP_011795.1 6321718 853196 complement(1048805..1049965) 1 NC_001139.8 Scw4p; Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating 1049965 SCW4 853196 SCW4 Saccharomyces cerevisiae Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating NP_011795.1 1048805 R 4932 CDS NP_011796.1 6321719 853197 complement(1050917..1051732) 1 NC_001139.8 Pxr1p; Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain 1051732 PXR1 853197 PXR1 Saccharomyces cerevisiae Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain NP_011796.1 1050917 R 4932 CDS NP_011797.1 6321720 853198 1052831..1057264 1 NC_001139.8 Yor1p; Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin 1057264 YOR1 853198 YOR1 Saccharomyces cerevisiae Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin NP_011797.1 1052831 D 4932 CDS NP_011798.1 6321721 853199 complement(1057790..1058731) 1 NC_001139.8 Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance; Bgl2p 1058731 BGL2 853199 BGL2 Saccharomyces cerevisiae Bgl2p NP_011798.1 1057790 R 4932 CDS NP_011799.1 6321722 853200 complement(1059022..1060047) 1 NC_001139.8 Ygr283cp; Protein of unknown function; may interact with ribosomes, based on co-purification experiments; deletion mutant is resistant to fluconazole; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus 1060047 853200 YGR283C Saccharomyces cerevisiae Protein of unknown function; may interact with ribosomes, based on co-purification experiments; deletion mutant is resistant to fluconazole; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus NP_011799.1 1059022 R 4932 CDS NP_011800.1 6321723 853201 complement(1060665..1061597) 1 NC_001139.8 Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo; Erv29p 1061597 ERV29 853201 ERV29 Saccharomyces cerevisiae Erv29p NP_011800.1 1060665 R 4932 CDS NP_011801.1 6321724 853202 complement(1061859..1063160) 1 NC_001139.8 Zuo1p; Cytosolic ribosome-associated chaperone that acts, together with Ssz1p and the Ssb proteins, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p 1063160 ZUO1 853202 ZUO1 Saccharomyces cerevisiae Cytosolic ribosome-associated chaperone that acts, together with Ssz1p and the Ssb proteins, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p NP_011801.1 1061859 R 4932 CDS NP_011802.1 6321725 853203 complement(1063820..1064947) 1 NC_001139.8 Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant; Bio2p 1064947 BIO2 853203 BIO2 Saccharomyces cerevisiae Bio2p NP_011802.1 1063820 R 4932 CDS NP_011803.1 6321726 853204 complement(1067229..1068998) 1 NC_001139.8 Ygr287cp; Protein of unknown function that may interact with ribosomes, based on co-purification experiments; has similarity to alpha-D-glucosidase (maltase); authentic, non-tagged protein detected in purified mitochondria in high-throughput studies 1068998 853204 YGR287C Saccharomyces cerevisiae Protein of unknown function that may interact with ribosomes, based on co-purification experiments; has similarity to alpha-D-glucosidase (maltase); authentic, non-tagged protein detected in purified mitochondria in high-throughput studies NP_011803.1 1067229 R 4932 CDS NP_011804.1 6321727 853205 1070300..1071721 1 NC_001139.8 Mal13p; MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C 1071721 MAL13 853205 MAL13 Saccharomyces cerevisiae MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C NP_011804.1 1070300 D 4932 CDS NP_011805.1 6321729 853207 complement(1073970..1075820) 1 NC_001139.8 Maltose permease, inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; Mal11p 1075820 MAL11 853207 MAL11 Saccharomyces cerevisiae Mal11p NP_011805.1 1073970 R 4932 CDS NP_011808.1 6321731 853209 1076606..1078360 1 NC_001139.8 Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; Mal12p 1078360 MAL12 853209 MAL12 Saccharomyces cerevisiae Mal12p NP_011808.1 1076606 D 4932 CDS NP_011810.1 6321732 853210 1080313..1080675 1 NC_001139.8 Pau12p 1080675 PAU12 853210 PAU12 Saccharomyces cerevisiae Pau12p NP_011810.1 1080313 D 4932 CDS NP_011811.1 6321734 853212 complement(1081591..1082736) 1 NC_001139.8 Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; Cos6p 1082736 COS6 853212 COS6 Saccharomyces cerevisiae Cos6p NP_011811.1 1081591 R 4932 CDS NP_011812.1 6321735 853213 join(1084871..1084889,1085038..1090598) 1 NC_001139.8 Yrf1-3p; Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p 1090598 YRF1-3 853213 YRF1-3 Saccharomyces cerevisiae Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p NP_011812.1 1084871 D 4932 CDS NP_011813.1 6321737 856335 complement(join(445..1897,2670..3310)) 1 NC_001140.5 Yhl050cp; Putative protein of unknown function, potential Cdc28p substrate 3310 856335 YHL050C Saccharomyces cerevisiae Putative protein of unknown function, potential Cdc28p substrate NP_011813.1 445 R 4932 CDS NP_011814.1 6321738 856336 complement(3725..4540) 1 NC_001140.5 Yhl049cp; Putative protein of unknown function 4540 856336 YHL049C Saccharomyces cerevisiae Putative protein of unknown function NP_011814.1 3725 R 4932 CDS NP_878084.1 33438802 1466524 complement(5662..5796) 1 NC_001140.5 Yhl048c-ap; Putative protein of unknown function; identified by expression profiling and mass spectrometry 5796 1466524 YHL048C-A Saccharomyces cerevisiae Putative protein of unknown function; identified by expression profiling and mass spectrometry NP_878084.1 5662 R 4932 CDS NP_011815.1 6321739 856337 6400..7545 1 NC_001140.5 Nuclear membrane protein, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; regulation suggests a potential role in the unfolded protein response; Cos8p 7545 COS8 856337 COS8 Saccharomyces cerevisiae Cos8p NP_011815.1 6400 D 4932 CDS NP_011816.1 6321740 856338 complement(8298..10211) 1 NC_001140.5 Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C; Arn2p 10211 ARN2 856338 ARN2 Saccharomyces cerevisiae Arn2p NP_011816.1 8298 R 4932 CDS NP_011817.1 6321741 856339 complement(11921..12283) 1 NC_001140.5 Putative protein of unknown function; not an essential gene; Pau13p 12283 PAU13 856339 PAU13 Saccharomyces cerevisiae Pau13p NP_011817.1 11921 R 4932 CDS NP_011819.1 6321743 856341 13563..14270 1 NC_001140.5 Yhl044wp; Putative integral membrane protein, member of DUP240 gene family; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane in a punctate pattern 14270 856341 YHL044W Saccharomyces cerevisiae Putative integral membrane protein, member of DUP240 gene family; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane in a punctate pattern NP_011819.1 13563 D 4932 CDS NP_011820.1 6321744 856342 14899..15411 1 NC_001140.5 Putative protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; Ecm34p 15411 ECM34 856342 ECM34 Saccharomyces cerevisiae Ecm34p NP_011820.1 14899 D 4932 CDS NP_011821.1 6321745 856343 15665..16117 1 NC_001140.5 Yhl042wp; Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins 16117 856343 YHL042W Saccharomyces cerevisiae Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins NP_011821.1 15665 D 4932 CDS NP_011823.1 6321747 856345 complement(19085..20968) 1 NC_001140.5 Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; Arn1p 20968 ARN1 856345 ARN1 Saccharomyces cerevisiae Arn1p NP_011823.1 19085 R 4932 CDS NP_011824.1 6321748 856346 21780..23537 1 NC_001140.5 Yhl039wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 23537 856346 YHL039W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm NP_011824.1 21780 D 4932 CDS NP_011825.1 6321749 856347 complement(23614..25506) 1 NC_001140.5 Mitochondrial protein required for splicing of the group I intron aI5 of the COB pre-mRNA, binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene; Cbp2p 25506 CBP2 856347 CBP2 Saccharomyces cerevisiae Cbp2p NP_011825.1 23614 R 4932 CDS NP_011827.1 6321751 856349 26239..27879 1 NC_001140.5 Mup3p; Low affinity methionine permease, similar to Mup1p 27879 MUP3 856349 MUP3 Saccharomyces cerevisiae Low affinity methionine permease, similar to Mup1p NP_011827.1 26239 D 4932 CDS NP_011828.1 6321752 856350 complement(27976..32754) 1 NC_001140.5 Vmr1p; Protein of unknown function that may interact with ribosomes, based on co-purification experiments; member of the ATP-binding cassette (ABC) family; potential Cdc28p substrate; detected in purified mitochondria in high-throughput studies 32754 VMR1 856350 VMR1 Saccharomyces cerevisiae Protein of unknown function that may interact with ribosomes, based on co-purification experiments; member of the ATP-binding cassette (ABC) family; potential Cdc28p substrate; detected in purified mitochondria in high-throughput studies NP_011828.1 27976 R 4932 CDS NP_011829.1 6321753 856351 complement(33191..34075) 1 NC_001140.5 Sbp1p; Putative RNA binding protein; involved in translational repression and found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11 34075 SBP1 856351 SBP1 Saccharomyces cerevisiae Putative RNA binding protein; involved in translational repression and found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11 NP_011829.1 33191 R 4932 CDS NP_011830.1 6321754 856352 complement(35253..36023) 1 NC_001140.5 Rpl8ap; Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Bp and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits 36023 RPL8A 856352 RPL8A Saccharomyces cerevisiae Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Bp and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits NP_011830.1 35253 R 4932 CDS NP_011831.1 6321755 856353 complement(36377..38506) 1 NC_001140.5 Gut1p; Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p 38506 GUT1 856353 GUT1 Saccharomyces cerevisiae Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p NP_011831.1 36377 R 4932 CDS NP_011832.1 6321756 856354 complement(38813..39484) 1 NC_001140.5 v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28; Gos1p 39484 GOS1 856354 GOS1 Saccharomyces cerevisiae Gos1p NP_011832.1 38813 R 4932 CDS NP_011833.1 6321757 856355 40082..45688 1 NC_001140.5 Major component of the proteasome; tethers the proteasome core particle to the regulatory particle, and enhances the stability of the proteasome; Ecm29p 45688 ECM29 856355 ECM29 Saccharomyces cerevisiae Ecm29p NP_011833.1 40082 D 4932 CDS NP_011834.1 6321758 856356 complement(45927..47966) 1 NC_001140.5 Oca5p; Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts 47966 OCA5 856356 OCA5 Saccharomyces cerevisiae Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts NP_011834.1 45927 R 4932 CDS NP_011835.1 6321759 856357 48761..50578 1 NC_001140.5 Wsc4p; ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3 50578 WSC4 856357 WSC4 Saccharomyces cerevisiae ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3 NP_011835.1 48761 D 4932 CDS NP_011836.1 6321760 856358 51109..52986 1 NC_001140.5 Transcriptional repressor involved in response to pH and in cell wall construction; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by proteolytic processing; similar to A. nidulans PacC; Rim101p 52986 RIM101 856358 RIM101 Saccharomyces cerevisiae Rim101p NP_011836.1 51109 D 4932 CDS NP_011837.2 82795253 856359 complement(53217..54164) 1 NC_001140.5 Yhl026cp; Putative protein of unknown function; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History) 54164 856359 YHL026C Saccharomyces cerevisiae Putative protein of unknown function; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History) NP_011837.2 53217 R 4932 CDS NP_011838.1 6321762 856360 54849..55847 1 NC_001140.5 Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p; Snf6p 55847 SNF6 856360 SNF6 Saccharomyces cerevisiae Snf6p NP_011838.1 54849 D 4932 CDS NP_011839.1 6321763 856361 56647..58788 1 NC_001140.5 Rim4p; Putative RNA-binding protein required for the expression of early and middle sporulation genes 58788 RIM4 856361 RIM4 Saccharomyces cerevisiae Putative RNA-binding protein required for the expression of early and middle sporulation genes NP_011839.1 56647 D 4932 CDS NP_011840.1 6321764 856362 complement(59121..62561) 1 NC_001140.5 Rmd11p; Protein required for sporulation 62561 RMD11 856362 RMD11 Saccharomyces cerevisiae Protein required for sporulation NP_011840.1 59121 R 4932 CDS NP_011841.1 6321765 856364 complement(62959..64155) 1 NC_001140.5 Spo11p; Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation 64155 SPO11 856364 SPO11 Saccharomyces cerevisiae Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation NP_011841.1 62959 R 4932 CDS NP_011842.1 6321766 856365 complement(64459..65856) 1 NC_001140.5 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss (petite formation); Aim17p 65856 AIM17 856365 AIM17 Saccharomyces cerevisiae Aim17p NP_011842.1 64459 R 4932 CDS NP_011843.1 6321767 856366 complement(66239..67453) 1 NC_001140.5 Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance; Opi1p 67453 OPI1 856366 OPI1 Saccharomyces cerevisiae Opi1p NP_011843.1 66239 R 4932 CDS NP_011844.1 6321768 856367 complement(67728..69545) 1 NC_001140.5 Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport; Apm2p 69545 APM2 856367 APM2 Saccharomyces cerevisiae Apm2p NP_011844.1 67728 R 4932 CDS NP_011845.1 6321769 856368 69705..70067 1 NC_001140.5 Yhl018wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria and is induced in response to the DNA-damaging agent MMS 70067 856368 YHL018W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria and is induced in response to the DNA-damaging agent MMS NP_011845.1 69705 D 4932 CDS NP_011846.1 6321770 856369 70273..71871 1 NC_001140.5 Yhl017wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles 71871 856369 YHL017W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles NP_011846.1 70273 D 4932 CDS NP_011847.1 6321771 856370 complement(72034..74241) 1 NC_001140.5 Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway; Dur3p 74241 DUR3 856370 DUR3 Saccharomyces cerevisiae Dur3p NP_011847.1 72034 R 4932 CDS NP_878085.1 33438803 1466525 74696..74779 1 NC_001140.5 Yhl015w-ap; Putative protein of unknown function 74779 1466525 YHL015W-A Saccharomyces cerevisiae Putative protein of unknown function NP_878085.1 74696 D 4932 CDS NP_011848.1 6321772 856371 75409..75774 1 NC_001140.5 Rps20p; Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; has similarity to E. coli S10 and rat S20 ribosomal proteins 75774 RPS20 856371 RPS20 Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; has similarity to E. coli S10 and rat S20 ribosomal proteins NP_011848.1 75409 D 4932 CDS NP_011849.1 6321773 856372 complement(76094..77311) 1 NC_001140.5 Ylf2p; Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 77311 YLF2 856372 YLF2 Saccharomyces cerevisiae Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_011849.1 76094 R 4932 CDS NP_011850.1 6321774 856373 complement(77427..78350) 1 NC_001140.5 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization; Otu2p 78350 OTU2 856373 OTU2 Saccharomyces cerevisiae Otu2p NP_011850.1 77427 R 4932 CDS NP_011851.1 6321775 856374 78932..80413 1 NC_001140.5 Yhl012wp; Putative protein of unknown function, has some homology to Ugp1p, which encodes UDP-glucose pyrophosphorylase 80413 856374 YHL012W Saccharomyces cerevisiae Putative protein of unknown function, has some homology to Ugp1p, which encodes UDP-glucose pyrophosphorylase NP_011851.1 78932 D 4932 CDS NP_011852.1 6321776 856375 complement(80650..81612) 1 NC_001140.5 Prs3p; 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involved in nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes 81612 PRS3 856375 PRS3 Saccharomyces cerevisiae 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involved in nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes NP_011852.1 80650 R 4932 CDS NP_011853.1 6321777 856376 complement(81960..83717) 1 NC_001140.5 Yhl010cp; Putative protein of unknown function, contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences 83717 856376 YHL010C Saccharomyces cerevisiae Putative protein of unknown function, contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences NP_011853.1 81960 R 4932 CDS NP_011854.1 6321778 856377 complement(84064..85056) 1 NC_001140.5 Yap3p; Basic leucine zipper (bZIP) transcription factor 85056 YAP3 856377 YAP3 Saccharomyces cerevisiae Basic leucine zipper (bZIP) transcription factor NP_011854.1 84064 R 4932 CDS NP_058133.1 7839180 856380 join(85905..86990,86992..91314) 1 NC_001140.5 Yhl009w-bp; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 91314 856380 YHL009W-B Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_058133.1 85905 D 4932 CDS NP_058134.1 7839179 856379 85905..87146 1 NC_001140.5 Yhl009w-ap; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 87146 856379 YHL009W-A Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_058134.1 85905 D 4932 CDS NP_011855.1 6321779 856381 complement(92623..94506) 1 NC_001140.5 Yhl008cp; Putative protein of unknown function, does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole 94506 856381 YHL008C Saccharomyces cerevisiae Putative protein of unknown function, does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole NP_011855.1 92623 R 4932 CDS NP_011856.1 6321780 856382 complement(95114..97933) 1 NC_001140.5 Ste20p; Signal transducing kinase of the PAK (p21-activated kinase) family, involved in pheromone response and pseudohyphal/invasive growth pathways, activated by Cdc42p; binds Ste4p at a GBB motif present in noncatalytic domains of PAK kinases 97933 STE20 856382 STE20 Saccharomyces cerevisiae Signal transducing kinase of the PAK (p21-activated kinase) family, involved in pheromone response and pseudohyphal/invasive growth pathways, activated by Cdc42p; binds Ste4p at a GBB motif present in noncatalytic domains of PAK kinases NP_011856.1 95114 R 4932 CDS NP_011857.2 41629684 856383 complement(98339..98791) 1 NC_001140.5 Shu1p; Protein of unassigned function involved in mutation suppression, important for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation; associates with Shu2p, Psy3p, and Csm2p 98791 SHU1 856383 SHU1 Saccharomyces cerevisiae Protein of unassigned function involved in mutation suppression, important for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation; associates with Shu2p, Psy3p, and Csm2p NP_011857.2 98339 R 4932 CDS NP_011859.1 6321782 856384 99215..100399 1 NC_001140.5 Mrp4p; Mitochondrial ribosomal protein of the small subunit 100399 MRP4 856384 MRP4 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the small subunit NP_011859.1 99215 D 4932 CDS NP_011860.1 6321784 856386 complement(100644..101879) 1 NC_001140.5 Lag1p; Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p 101879 LAG1 856386 LAG1 Saccharomyces cerevisiae Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p NP_011860.1 100644 R 4932 CDS NP_011861.1 6321785 856387 102607..103965 1 NC_001140.5 Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes; Hse1p 103965 HSE1 856387 HSE1 Saccharomyces cerevisiae Hse1p NP_011861.1 102607 D 4932 CDS NP_011862.1 6321786 856388 join(104272..104400,104799..105086) 1 NC_001140.5 Rpl14bp; Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl14Ap and has similarity to rat L14 ribosomal protein 105086 RPL14B 856388 RPL14B Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl14Ap and has similarity to rat L14 ribosomal protein NP_011862.1 104272 D 4932 CDS NP_011863.1 6321787 856389 106050..107363 1 NC_001140.5 Osh7p; Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability 107363 OSH7 856389 OSH7 Saccharomyces cerevisiae Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability NP_011863.1 106050 D 4932 CDS NP_011864.1 6321788 856390 join(107821..107826,107890..108117) 1 NC_001140.5 Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain; Qcr10p 108117 QCR10 856390 QCR10 Saccharomyces cerevisiae Qcr10p NP_011864.1 107821 D 4932 CDS NP_011865.1 6321789 856391 108807..109880 1 NC_001140.5 Mitochondrial carrier protein involved in the accumulation of CoA in the mitochondrial matrix; homolog of human Graves disease protein; does not encode an isozyme of Leu4p, as first hypothesized; Leu5p 109880 LEU5 856391 LEU5 Saccharomyces cerevisiae Leu5p NP_011865.1 108807 D 4932 CDS NP_011866.1 6321790 856392 complement(110023..111312) 1 NC_001140.5 Yhr003cp; Protein of unknown function, localized to the mitochondrial outer membrane 111312 856392 YHR003C Saccharomyces cerevisiae Protein of unknown function, localized to the mitochondrial outer membrane NP_011866.1 110023 R 4932 CDS NP_011867.1 6321791 856393 complement(111749..113089) 1 NC_001140.5 Nem1p; Catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme, which regulates nuclear growth by controlling recruitment of Pah1p onto promoters of phospholipid biosynthetic genes; required for normal nuclear envelope morphology and sporulation 113089 NEM1 856393 NEM1 Saccharomyces cerevisiae Catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme, which regulates nuclear growth by controlling recruitment of Pah1p onto promoters of phospholipid biosynthetic genes; required for normal nuclear envelope morphology and sporulation NP_011867.1 111749 R 4932 CDS NP_011868.1 6321792 856394 complement(113494..114912) 1 NC_001140.5 Gpa1p; GTP-binding alpha subunit of the heterotrimeric G protein that couples to pheromone receptors; negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response; activates Vps34p at the endosome 114912 GPA1 856394 GPA1 Saccharomyces cerevisiae GTP-binding alpha subunit of the heterotrimeric G protein that couples to pheromone receptors; negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response; activates Vps34p at the endosome NP_011868.1 113494 R 4932 CDS NP_011869.1 6321793 856395 complement(115615..115896) 1 NC_001140.5 Mrs11p; Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that mediates insertion of hydrophobic proteins at the inner membrane, has homology to Mrs5p, which is also involved in this process 115896 MRS11 856395 MRS11 Saccharomyces cerevisiae Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that mediates insertion of hydrophobic proteins at the inner membrane, has homology to Mrs5p, which is also involved in this process NP_011869.1 115615 R 4932 CDS NP_011870.1 6321794 856397 117809..119434 1 NC_001140.5 Transcription factor, activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; Stp2p 119434 STP2 856397 STP2 Saccharomyces cerevisiae Stp2p NP_011870.1 117809 D 4932 CDS NP_011871.1 6321795 856398 complement(120086..121678) 1 NC_001140.5 Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; Erg11p 121678 ERG11 856398 ERG11 Saccharomyces cerevisiae Erg11p NP_011871.1 120086 R 4932 CDS NP_878086.1 33438804 1466526 complement(122545..122760) 1 NC_001140.5 Yhr007c-ap; Putative protein of unknown function; identified by expression profiling and mass spectrometry 122760 1466526 YHR007C-A Saccharomyces cerevisiae Putative protein of unknown function; identified by expression profiling and mass spectrometry NP_878086.1 122545 R 4932 CDS NP_011872.1 6321796 856399 complement(122884..123585) 1 NC_001140.5 Sod2p; Mitochondrial superoxide dismutase, protects cells against oxygen toxicity; phosphorylated 123585 SOD2 856399 SOD2 Saccharomyces cerevisiae Mitochondrial superoxide dismutase, protects cells against oxygen toxicity; phosphorylated NP_011872.1 122884 R 4932 CDS NP_011873.1 6321797 856400 complement(124104..125675) 1 NC_001140.5 Yhr009cp; Putative protein of unknown function; not an essential gene 125675 856400 YHR009C Saccharomyces cerevisiae Putative protein of unknown function; not an essential gene NP_011873.1 124104 R 4932 CDS NP_011874.1 6321798 856401 join(126515..126545,127107..127486) 1 NC_001140.5 Rpl27ap; Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Bp and has similarity to rat L27 ribosomal protein 127486 RPL27A 856401 RPL27A Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Bp and has similarity to rat L27 ribosomal protein NP_011874.1 126515 D 4932 CDS NP_011875.1 6321799 856402 127774..129114 1 NC_001140.5 Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth; Dia4p 129114 DIA4 856402 DIA4 Saccharomyces cerevisiae Dia4p NP_011875.1 127774 D 4932 CDS NP_011876.1 6321800 856403 join(129475..129522,129642..130442) 1 NC_001140.5 Vps29p; Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval 130442 VPS29 856403 VPS29 Saccharomyces cerevisiae Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval NP_011876.1 129475 D 4932 CDS NP_011877.1 6321801 856404 complement(130724..131440) 1 NC_001140.5 Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing; Ard1p 131440 ARD1 856404 ARD1 Saccharomyces cerevisiae Ard1p NP_011877.1 130724 R 4932 CDS NP_011878.1 6321802 856405 132040..132915 1 NC_001140.5 Spo13p; Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II 132915 SPO13 856405 SPO13 Saccharomyces cerevisiae Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II NP_011878.1 132040 D 4932 CDS NP_011879.1 6321803 856408 134547..136526 1 NC_001140.5 Putative RNA-binding protein, interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export; Mip6p 136526 MIP6 856408 MIP6 Saccharomyces cerevisiae Mip6p NP_011879.1 134547 D 4932 CDS NP_011880.1 6321804 856409 complement(join(136874..138233,138402..138448)) 1 NC_001140.5 Ysc84p; Protein involved in the organization of the actin cytoskeleton; contains SH3 domain similar to Rvs167p 138448 YSC84 856409 YSC84 Saccharomyces cerevisiae Protein involved in the organization of the actin cytoskeleton; contains SH3 domain similar to Rvs167p NP_011880.1 136874 R 4932 CDS NP_011881.1 6321805 856410 138687..139844 1 NC_001140.5 Ysc83p; Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83 139844 YSC83 856410 YSC83 Saccharomyces cerevisiae Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83 NP_011881.1 138687 D 4932 CDS NP_011882.1 6321806 856411 complement(140004..141395) 1 NC_001140.5 Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway; Arg4p 141395 ARG4 856411 ARG4 Saccharomyces cerevisiae Arg4p NP_011882.1 140004 R 4932 CDS NP_011883.1 6321807 856412 complement(141887..143551) 1 NC_001140.5 Ded81p; Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA 143551 DED81 856412 DED81 Saccharomyces cerevisiae Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA NP_011883.1 141887 R 4932 CDS NP_011884.1 6321808 856413 143989..146055 1 NC_001140.5 Yhr020wp; Protein of unknown function that may interact with ribosomes, based on co-purification experiments; has similarity to proline-tRNA ligase; YHR020W is an essential gene 146055 856413 YHR020W Saccharomyces cerevisiae Protein of unknown function that may interact with ribosomes, based on co-purification experiments; has similarity to proline-tRNA ligase; YHR020W is an essential gene NP_011884.1 143989 D 4932 CDS NP_011885.1 6321809 856415 complement(join(147864..148109,148660..148662)) 1 NC_001140.5 Rps27bp; Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Ap and has similarity to rat S27 ribosomal protein 148662 RPS27B 856415 RPS27B Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Ap and has similarity to rat S27 ribosomal protein NP_011885.1 147864 R 4932 CDS NP_011886.1 6321810 856416 149218..149673 1 NC_001140.5 Non-essential protein of unknown function; Ecm12p 149673 ECM12 856416 ECM12 Saccharomyces cerevisiae Ecm12p NP_011886.1 149218 D 4932 CDS NP_011887.1 6321811 856417 complement(149568..150338) 1 NC_001140.5 Yhr022cp; Putative protein of unknown function; YHR022C is not an essential gene. 150338 856417 YHR022C Saccharomyces cerevisiae Putative protein of unknown function; YHR022C is not an essential gene. NP_011887.1 149568 R 4932 CDS NP_878087.1 33438805 1466527 complement(151210..151299) 1 NC_001140.5 Yhr022c-ap; Putative protein of unknown function, identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 151299 1466527 YHR022C-A Saccharomyces cerevisiae Putative protein of unknown function, identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching NP_878087.1 151210 R 4932 CDS NP_011888.1 6321812 856418 151659..157445 1 NC_001140.5 Type II myosin heavy chain, required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively; Myo1p 157445 MYO1 856418 MYO1 Saccharomyces cerevisiae Myo1p NP_011888.1 151659 D 4932 CDS NP_011889.1 6321813 856419 complement(157737..159185) 1 NC_001140.5 Mas2p; Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins 159185 MAS2 856419 MAS2 Saccharomyces cerevisiae Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins NP_011889.1 157737 R 4932 CDS NP_011890.1 6321814 856420 159431..160504 1 NC_001140.5 Thr1p; Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway 160504 THR1 856420 THR1 Saccharomyces cerevisiae Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway NP_011890.1 159431 D 4932 CDS NP_011891.1 6321815 856421 160837..161478 1 NC_001140.5 Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain; Ppa1p 161478 PPA1 856421 PPA1 Saccharomyces cerevisiae Ppa1p NP_011891.1 160837 D 4932 CDS NP_011892.1 6321816 856422 complement(161723..164704) 1 NC_001140.5 Rpn1p; Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat (LRR) domain, a site for protein?protein interactions 164704 RPN1 856422 RPN1 Saccharomyces cerevisiae Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat (LRR) domain, a site for protein?protein interactions NP_011892.1 161723 R 4932 CDS NP_011893.1 6321817 856423 complement(164971..167427) 1 NC_001140.5 Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p; Dap2p 167427 DAP2 856423 DAP2 Saccharomyces cerevisiae Dap2p NP_011893.1 164971 R 4932 CDS NP_011894.1 6321818 856424 complement(167670..168554) 1 NC_001140.5 Yhi9p; Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production 168554 YHI9 856424 YHI9 Saccharomyces cerevisiae Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production NP_011894.1 167670 R 4932 CDS NP_011895.1 6321819 856425 complement(168883..170337) 1 NC_001140.5 Slt2p; Serine/threonine MAP kinase involved in regulating the maintenance of cell wall integrity and progression through the cell cycle; regulated by the PKC1-mediated signaling pathway 170337 SLT2 856425 SLT2 Saccharomyces cerevisiae Serine/threonine MAP kinase involved in regulating the maintenance of cell wall integrity and progression through the cell cycle; regulated by the PKC1-mediated signaling pathway NP_011895.1 168883 R 4932 CDS NP_011896.1 6321820 856426 complement(170792..172963) 1 NC_001140.5 Rrm3p; DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p 172963 RRM3 856426 RRM3 Saccharomyces cerevisiae DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p NP_011896.1 170792 R 4932 CDS NP_011897.1 6321821 856427 173337..175082 1 NC_001140.5 Yhr032wp; Putative protein of unknown function; putative substrate of the cAMP-dependent protein kinase (PKA) 175082 856427 YHR032W Saccharomyces cerevisiae Putative protein of unknown function; putative substrate of the cAMP-dependent protein kinase (PKA) NP_011897.1 173337 D 4932 CDS NP_011898.1 6321822 856428 175541..176812 1 NC_001140.5 Yhr033wp; Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm 176812 856428 YHR033W Saccharomyces cerevisiae Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm NP_011898.1 175541 D 4932 CDS NP_011899.1 6321823 856429 complement(176958..177992) 1 NC_001140.5 Protein of unresolved function; may function in protein folding and/or rRNA processing, interacts with a chaperone (Hsp82p), two chromatin remodeling factors (Rvb1p, Rvb2p) and two rRNA processing factors (Rrp43p, Nop58p); Pih1p 177992 PIH1 856429 PIH1 Saccharomyces cerevisiae Pih1p NP_011899.1 176958 R 4932 CDS NP_011900.1 6321824 856430 178212..180104 1 NC_001140.5 Yhr035wp; Putative protein of unknown function; not an essential gene 180104 856430 YHR035W Saccharomyces cerevisiae Putative protein of unknown function; not an essential gene NP_011900.1 178212 D 4932 CDS NP_011901.1 6321825 856431 180338..181753 1 NC_001140.5 Essential nuclear envelope integral membrane protein identified as a suppressor of a cold-sensitive mutant of CRM1, a karyopherin; homologous to and interacts with Brr6p, which is a nuclear envelope protein involved in nuclear export; Brl1p 181753 BRL1 856431 BRL1 Saccharomyces cerevisiae Brl1p NP_011901.1 180338 D 4932 CDS NP_011902.1 6321826 856432 181970..183697 1 NC_001140.5 Put2p; Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism 183697 PUT2 856432 PUT2 Saccharomyces cerevisiae Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism NP_011902.1 181970 D 4932 CDS NP_011903.1 6321827 856433 184059..184751 1 NC_001140.5 Rrf1p; Mitochondrial ribosome recycling factor, essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria 184751 RRF1 856433 RRF1 Saccharomyces cerevisiae Mitochondrial ribosome recycling factor, essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria NP_011903.1 184059 D 4932 CDS NP_011904.1 6321828 856434 complement(184868..186802) 1 NC_001140.5 Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids; Msc7p 186802 MSC7 856434 MSC7 Saccharomyces cerevisiae Msc7p NP_011904.1 184868 R 4932 CDS NP_011905.1 6321829 856435 complement(join(187166..187507,187670..187672)) 1 NC_001140.5 Vma10p; Vacuolar H+ ATPase subunit G of the catalytic (V1) sector, involved in vacuolar acidification 187672 VMA10 856435 VMA10 Saccharomyces cerevisiae Vacuolar H+ ATPase subunit G of the catalytic (V1) sector, involved in vacuolar acidification NP_011905.1 187166 R 4932 CDS NP_011906.1 6321830 856436 187917..189017 1 NC_001140.5 Essential protein required for the accumulation of box C/D snoRNA; Bcd1p 189017 BCD1 856436 BCD1 Saccharomyces cerevisiae Bcd1p NP_011906.1 187917 D 4932 CDS NP_011907.1 6321831 856437 complement(join(189124..189742,189844..189857)) 1 NC_001140.5 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance; Srb2p 189857 SRB2 856437 SRB2 Saccharomyces cerevisiae Srb2p NP_011907.1 189124 R 4932 CDS NP_011908.1 6321832 856438 190536..192611 1 NC_001140.5 Ncp1p; NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p 192611 NCP1 856438 NCP1 Saccharomyces cerevisiae NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p NP_011908.1 190536 D 4932 CDS NP_011909.1 6321833 856439 complement(192798..193538) 1 NC_001140.5 Dog2p; 2-deoxyglucose-6-phosphate phosphatase, member of a family of low molecular weight phosphatases, similar to Dog1p, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed 193538 DOG2 856439 DOG2 Saccharomyces cerevisiae 2-deoxyglucose-6-phosphate phosphatase, member of a family of low molecular weight phosphatases, similar to Dog1p, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed NP_011909.1 192798 R 4932 CDS NP_011910.1 6321834 856440 complement(194061..194801) 1 NC_001140.5 Dog1p; 2-deoxyglucose-6-phosphate phosphatase, similar to Dog2p, member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified 194801 DOG1 856440 DOG1 Saccharomyces cerevisiae 2-deoxyglucose-6-phosphate phosphatase, similar to Dog2p, member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified NP_011910.1 194061 R 4932 CDS NP_011911.1 6321835 856441 195544..197226 1 NC_001140.5 Yhr045wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum 197226 856441 YHR045W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum NP_011911.1 195544 D 4932 CDS NP_011912.1 6321836 856442 complement(197391..198278) 1 NC_001140.5 Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate; Inm1p 198278 INM1 856442 INM1 Saccharomyces cerevisiae Inm1p NP_011912.1 197391 R 4932 CDS NP_011913.1 6321837 856443 complement(198733..201303) 1 NC_001140.5 Arginine/alanine aminopeptidase, overproduction stimulates glycogen accumulation; Aap1p 201303 AAP1 856443 AAP1 Saccharomyces cerevisiae Aap1p NP_011913.1 198733 R 4932 CDS NP_011914.1 6321838 856444 204600..206144 1 NC_001140.5 Yhk8p; Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles 206144 YHK8 856444 YHK8 Saccharomyces cerevisiae Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles NP_011914.1 204600 D 4932 CDS NP_011915.1 6321839 856445 206455..207186 1 NC_001140.5 Serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to Fsh2p and Fsh3p; Fsh1p 207186 FSH1 856445 FSH1 Saccharomyces cerevisiae Fsh1p NP_011915.1 206455 D 4932 CDS NP_011917.1 6321841 856447 207648..209297 1 NC_001140.5 Smf2p; Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins 209297 SMF2 856447 SMF2 Saccharomyces cerevisiae Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins NP_011917.1 207648 D 4932 CDS NP_878088.1 33438806 1466528 209469..209639 1 NC_001140.5 Yhr050w-ap; Protein of unknown function; identified by expression profiling and mass spectrometry 209639 1466528 YHR050W-A Saccharomyces cerevisiae Protein of unknown function; identified by expression profiling and mass spectrometry NP_878088.1 209469 D 4932 CDS NP_011918.1 6321842 856448 209699..210145 1 NC_001140.5 Subunit VI of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels; Cox6p 210145 COX6 856448 COX6 Saccharomyces cerevisiae Cox6p NP_011918.1 209699 D 4932 CDS NP_011919.1 6321843 856449 210842..211972 1 NC_001140.5 Essential protein that interacts with proteasome components and has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles; Cic1p 211972 CIC1 856449 CIC1 Saccharomyces cerevisiae Cic1p NP_011919.1 210842 D 4932 CDS NP_011920.1 6321844 856450 complement(212537..212722) 1 NC_001140.5 Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C; Cup1-1p 212722 CUP1-1 856450 CUP1-1 Saccharomyces cerevisiae Cup1-1p NP_011920.1 212537 R 4932 CDS NP_011921.1 6321845 856451 complement(213187..214251) 1 NC_001140.5 Yhr054cp; Putative protein of unknown function 214251 856451 YHR054C Saccharomyces cerevisiae Putative protein of unknown function NP_011921.1 213187 R 4932 CDS NP_011922.1 6321846 856452 complement(214535..214720) 1 NC_001140.5 Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C; Cup1-2p 214720 CUP1-2 856452 CUP1-2 Saccharomyces cerevisiae Cup1-2p NP_011922.1 214535 R 4932 CDS NP_011923.2 41629685 856453 complement(215185..217836) 1 NC_001140.5 Rsc30p; Component of the RSC chromatin remodeling complex; non-essential gene required for regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc3p; null mutants are osmosensitive 217836 RSC30 856453 RSC30 Saccharomyces cerevisiae Component of the RSC chromatin remodeling complex; non-essential gene required for regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc3p; null mutants are osmosensitive NP_011923.2 215185 R 4932 CDS NP_011924.1 6321848 856454 complement(218228..218845) 1 NC_001140.5 Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway; Cpr2p 218845 CPR2 856454 CPR2 Saccharomyces cerevisiae Cpr2p NP_011924.1 218228 R 4932 CDS NP_011925.1 6321849 856455 complement(218999..219886) 1 NC_001140.5 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; Med6p 219886 MED6 856455 MED6 Saccharomyces cerevisiae Med6p NP_011925.1 218999 R 4932 CDS NP_011926.1 6321850 856456 220110..220502 1 NC_001140.5 Protein of unknown function, required for survival upon exposure to K1 killer toxin; Fyv4p 220502 FYV4 856456 FYV4 Saccharomyces cerevisiae Fyv4p NP_011926.1 220110 D 4932 CDS NP_011927.1 6321851 856457 220727..221272 1 NC_001140.5 Vma22p; Integral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER) 221272 VMA22 856457 VMA22 Saccharomyces cerevisiae Integral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER) NP_011927.1 220727 D 4932 CDS NP_011928.1 6321852 856458 complement(221536..222480) 1 NC_001140.5 Protein of unknown function involved in initiation of budding and cellular polarization, interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain; Gic1p 222480 GIC1 856458 GIC1 Saccharomyces cerevisiae Gic1p NP_011928.1 221536 R 4932 CDS NP_011929.1 6321853 856459 complement(222879..223760) 1 NC_001140.5 Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; Rpp1p 223760 RPP1 856459 RPP1 Saccharomyces cerevisiae Rpp1p NP_011929.1 222879 R 4932 CDS NP_011930.1 6321854 856460 complement(224032..225171) 1 NC_001140.5 Pan5p; 2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE 225171 PAN5 856460 PAN5 Saccharomyces cerevisiae 2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE NP_011930.1 224032 R 4932 CDS NP_011931.2 37362658 856461 complement(225527..227143) 1 NC_001140.5 Ssz1p; Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP 227143 SSZ1 856461 SSZ1 Saccharomyces cerevisiae Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP NP_011931.2 225527 R 4932 CDS NP_011932.2 37362659 856462 complement(227534..229039) 1 NC_001140.5 Rrp3p; Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity 229039 RRP3 856462 RRP3 Saccharomyces cerevisiae Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity NP_011932.2 227534 R 4932 CDS NP_011933.1 6321857 856463 229337..230698 1 NC_001140.5 Ssf1p; Constituent of 66S pre-ribosomal particles, required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family 230698 SSF1 856463 SSF1 Saccharomyces cerevisiae Constituent of 66S pre-ribosomal particles, required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family NP_011933.1 229337 D 4932 CDS NP_011934.1 6321858 856464 230972..231814 1 NC_001140.5 Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology; Htd2p 231814 HTD2 856464 HTD2 Saccharomyces cerevisiae Htd2p NP_011934.1 230972 D 4932 CDS NP_011935.1 6321859 856465 232135..233298 1 NC_001140.5 Dys1p; Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric 233298 DYS1 856465 DYS1 Saccharomyces cerevisiae Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric NP_011935.1 232135 D 4932 CDS NP_011936.1 6321860 856466 complement(233581..234660) 1 NC_001140.5 Rrp4p; 3'-5' exoribonuclease involved in rRNA processing; component of the exosome 3->5 exonuclease complex with Rrp41p, Rrp42p, Rrp43p and Dis3p 234660 RRP4 856466 RRP4 Saccharomyces cerevisiae 3'-5' exoribonuclease involved in rRNA processing; component of the exosome 3->5 exonuclease complex with Rrp41p, Rrp42p, Rrp43p and Dis3p NP_011936.1 233581 R 4932 CDS NP_011937.1 6321861 856467 234883..236382 1 NC_001140.5 tRNA(m(1)G37)methyltransferase, methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; highly conserved across Archaea, Bacteria, and Eukarya; Trm5p 236382 TRM5 856467 TRM5 Saccharomyces cerevisiae Trm5p NP_011937.1 234883 D 4932 CDS NP_011938.1 6321862 856468 237006..237695 1 NC_001140.5 Pcl5p; Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity 237695 PCL5 856468 PCL5 Saccharomyces cerevisiae Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity NP_011938.1 237006 D 4932 CDS NP_011939.1 6321863 856470 239100..241295 1 NC_001140.5 Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis; Erg7p 241295 ERG7 856470 ERG7 Saccharomyces cerevisiae Erg7p NP_011939.1 239100 D 4932 CDS NP_058135.1 7839181 856471 241666..241842 1 NC_001140.5 Nop10p; Constituent of small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs, which are required for pseudouridylation and processing of pre-18S rRNA 241842 NOP10 856471 NOP10 Saccharomyces cerevisiae Constituent of small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs, which are required for pseudouridylation and processing of pre-18S rRNA NP_058135.1 241666 D 4932 CDS NP_011940.1 6321864 856472 242584..245574 1 NC_001140.5 Osh3p; Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability 245574 OSH3 856472 OSH3 Saccharomyces cerevisiae Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability NP_011940.1 242584 D 4932 CDS NP_011941.1 6321865 856473 246195..248339 1 NC_001140.5 Qns1p; Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide 248339 QNS1 856473 QNS1 Saccharomyces cerevisiae Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide NP_011941.1 246195 D 4932 CDS NP_011942.1 6321866 856474 complement(248441..249643) 1 NC_001140.5 Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein; Ppe1p 249643 PPE1 856474 PPE1 Saccharomyces cerevisiae Ppe1p NP_011942.1 248441 R 4932 CDS NP_011943.2 154199605 856475 join(251103..251157,251251..252227) 1 NC_001140.5 Ptc7p; Mitochondrially localized type 2C protein phosphatase; expression induced by growth on ethanol and by sustained osmotic stress; possible role in carbon source utilization in low oxygen environments 252227 PTC7 856475 PTC7 Saccharomyces cerevisiae Mitochondrially localized type 2C protein phosphatase; expression induced by growth on ethanol and by sustained osmotic stress; possible role in carbon source utilization in low oxygen environments NP_011943.2 251103 D 4932 CDS NP_011944.2 6579193 856476 complement(join(252376..255639,255753..255758)) 1 NC_001140.5 Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance; Nmd2p 255758 NMD2 856476 NMD2 Saccharomyces cerevisiae Nmd2p NP_011944.2 252376 R 4932 CDS NP_011945.1 6321869 856477 256362..258020 1 NC_001140.5 Yhr078wp; High osmolarity-regulated gene of unknown function 258020 856477 YHR078W Saccharomyces cerevisiae High osmolarity-regulated gene of unknown function NP_011945.1 256362 D 4932 CDS NP_011946.1 6321870 856478 complement(258246..261593) 1 NC_001140.5 Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress; Ire1p 261593 IRE1 856478 IRE1 Saccharomyces cerevisiae Ire1p NP_011946.1 258246 R 4932 CDS NP_011947.2 81357323 856479 complement(join(262194..262356,262443..262555)) 1 NC_001140.5 Sae3p; Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p 262555 SAE3 856479 SAE3 Saccharomyces cerevisiae Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p NP_011947.2 262194 R 4932 CDS NP_011948.1 6321872 856480 complement(262803..266840) 1 NC_001140.5 Yhr080cp; Protein of unknown function that may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 266840 856480 YHR080C Saccharomyces cerevisiae Protein of unknown function that may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_011948.1 262803 R 4932 CDS NP_011949.1 6321873 856481 267540..268094 1 NC_001140.5 Substrate-specific nuclear cofactor for exosome activity in the processing of stable RNAs; required for telomere length maintenance; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination; Lrp1p 268094 LRP1 856481 LRP1 Saccharomyces cerevisiae Lrp1p NP_011949.1 267540 D 4932 CDS NP_011950.1 6321874 856482 complement(268461..271550) 1 NC_001140.5 Nonessential putative serine/threonine protein kinase of unknown cellular role; overproduction causes allele-specific suppression of the prp20-10 mutation; Ksp1p 271550 KSP1 856482 KSP1 Saccharomyces cerevisiae Ksp1p NP_011950.1 268461 R 4932 CDS NP_011951.1 6321875 856483 272629..273618 1 NC_001140.5 Sam35p; Essential component of the sorting and assembly machinery (SAM complex or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane 273618 SAM35 856483 SAM35 Saccharomyces cerevisiae Essential component of the sorting and assembly machinery (SAM complex or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane NP_011951.1 272629 D 4932 CDS NP_011952.1 6321876 856484 274176..276242 1 NC_001140.5 Transcription factor that is activated by a MAP kinase signaling cascade, activates genes involved in mating or pseudohyphal/invasive growth pathways; cooperates with Tec1p transcription factor to regulate genes specific for invasive growth; Ste12p 276242 STE12 856484 STE12 Saccharomyces cerevisiae Ste12p NP_011952.1 274176 D 4932 CDS NP_011953.1 6321877 856485 276766..277770 1 NC_001140.5 Ipi1p; Essential component of the Rix1 complex (with Rix1p and Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles 277770 IPI1 856485 IPI1 Saccharomyces cerevisiae Essential component of the Rix1 complex (with Rix1p and Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles NP_011953.1 276766 D 4932 CDS NP_011954.1 6321878 856486 278155..279726 1 NC_001140.5 RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of MER2 pre-mRNA; Nam8p 279726 NAM8 856486 NAM8 Saccharomyces cerevisiae Nam8p NP_011954.1 278155 D 4932 CDS NP_878089.1 33438807 1466529 280233..280394 1 NC_001140.5 Yhr086w-ap; Putative protein of unknown function; identified by fungal homology and RT-PCR 280394 1466529 YHR086W-A Saccharomyces cerevisiae Putative protein of unknown function; identified by fungal homology and RT-PCR NP_878089.1 280233 D 4932 CDS NP_011955.1 6321879 856487 280822..281157 1 NC_001140.5 Yhr087wp; Protein of unknown function involved in RNA metabolism; this single domain protein has structural similarity to the N-terminal domain of SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1/YLR022C) 281157 856487 YHR087W Saccharomyces cerevisiae Protein of unknown function involved in RNA metabolism; this single domain protein has structural similarity to the N-terminal domain of SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1/YLR022C) NP_011955.1 280822 D 4932 CDS NP_011956.1 6321880 856488 281497..282384 1 NC_001140.5 Rpf1p; Nucleolar protein involved in the assembly of the large ribosomal subunit; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA 282384 RPF1 856488 RPF1 Saccharomyces cerevisiae Nucleolar protein involved in the assembly of the large ribosomal subunit; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA NP_011956.1 281497 D 4932 CDS NP_011957.1 6321881 856489 complement(282683..283300) 1 NC_001140.5 Protein component of the H/ACA snoRNP pseudouridylase complex, involved in the modification and cleavage of the 18S pre-rRNA; Gar1p 283300 GAR1 856489 GAR1 Saccharomyces cerevisiae Gar1p NP_011957.1 282683 R 4932 CDS NP_011958.1 6321882 856490 complement(283779..284627) 1 NC_001140.5 Yng2p; Subunit of the NuA4 histone acetyltransferase complex that acetylates histone H4 and H2A; has similarity to the human tumor suppressor ING1 284627 YNG2 856490 YNG2 Saccharomyces cerevisiae Subunit of the NuA4 histone acetyltransferase complex that acetylates histone H4 and H2A; has similarity to the human tumor suppressor ING1 NP_011958.1 283779 R 4932 CDS NP_011959.1 6321883 856491 complement(284841..286772) 1 NC_001140.5 Msr1p; Mitochondrial arginyl-tRNA synthetase 286772 MSR1 856491 MSR1 Saccharomyces cerevisiae Mitochondrial arginyl-tRNA synthetase NP_011959.1 284841 R 4932 CDS NP_011960.1 6321884 856492 complement(287132..288814) 1 NC_001140.5 Hxt4p; High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose 288814 HXT4 856492 HXT4 Saccharomyces cerevisiae High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose NP_011960.1 287132 R 4932 CDS NP_011962.1 6321886 856494 complement(290916..292628) 1 NC_001140.5 Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; Hxt1p 292628 HXT1 856494 HXT1 Saccharomyces cerevisiae Hxt1p NP_011962.1 290916 R 4932 CDS NP_011964.1 6321888 856496 complement(294672..296450) 1 NC_001140.5 Hxt5p; Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs 296450 HXT5 856496 HXT5 Saccharomyces cerevisiae Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs NP_011964.1 294672 R 4932 CDS NP_011965.1 6321889 856497 complement(join(297388..298363,298488..298612)) 1 NC_001140.5 Yhr097cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus 298612 856497 YHR097C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus NP_011965.1 297388 R 4932 CDS NP_011966.1 6321890 856498 complement(299148..301937) 1 NC_001140.5 Sfb3p; Member of the Sec24p family; forms a complex, with Sec23p, that is involved in sorting of Pma1p into COPII vesicles; peripheral ER membrane protein; potential Cdc28p substrate 301937 SFB3 856498 SFB3 Saccharomyces cerevisiae Member of the Sec24p family; forms a complex, with Sec23p, that is involved in sorting of Pma1p into COPII vesicles; peripheral ER membrane protein; potential Cdc28p substrate NP_011966.1 299148 R 4932 CDS NP_011967.1 6321891 856499 302764..313998 1 NC_001140.5 Tra1p; Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation 313998 TRA1 856499 TRA1 Saccharomyces cerevisiae Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation NP_011967.1 302764 D 4932 CDS NP_011968.1 6321892 856500 complement(314119..314676) 1 NC_001140.5 Yhr100cp; Putative protein of unknown function, required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 314676 856500 YHR100C Saccharomyces cerevisiae Putative protein of unknown function, required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_011968.1 314119 R 4932 CDS NP_011969.1 6321893 856501 complement(join(314877..315774,315862..315971)) 1 NC_001140.5 Integral membrane protein of the endoplasmic reticulum, required for normal content of cell wall beta-1,6-glucan; Big1p 315971 BIG1 856501 BIG1 Saccharomyces cerevisiae Big1p NP_011969.1 314877 R 4932 CDS NP_011970.1 6321894 856502 316575..319817 1 NC_001140.5 Protein kinase of the PAK/Ste20 kinase family, required for cell integrity possibly through regulating 1,6-beta-glucan levels in the wall; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; Kic1p 319817 KIC1 856502 KIC1 Saccharomyces cerevisiae Kic1p NP_011970.1 316575 D 4932 CDS NP_011971.1 6321895 856503 320417..322975 1 NC_001140.5 Sbe22p; Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth 322975 SBE22 856503 SBE22 Saccharomyces cerevisiae Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth NP_011971.1 320417 D 4932 CDS NP_011972.1 6321896 856504 323412..324395 1 NC_001140.5 Gre3p; Aldose reductase involved in methylglyoxal, d-xylose and arabinose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway 324395 GRE3 856504 GRE3 Saccharomyces cerevisiae Aldose reductase involved in methylglyoxal, d-xylose and arabinose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway NP_011972.1 323412 D 4932 CDS NP_011973.1 6321897 856505 324769..325413 1 NC_001140.5 Ypt35p; Endosomal protein of unknown function that contains a phox (PX) homology domain and binds to both phosphatidylinositol-3-phosphate (PtdIns(3)P) and proteins involved in ER-Golgi or vesicular transport 325413 YPT35 856505 YPT35 Saccharomyces cerevisiae Endosomal protein of unknown function that contains a phox (PX) homology domain and binds to both phosphatidylinositol-3-phosphate (PtdIns(3)P) and proteins involved in ER-Golgi or vesicular transport NP_011973.1 324769 D 4932 CDS NP_011974.1 6321898 856506 325601..326629 1 NC_001140.5 Trr2p; Mitochondrial thioredoxin reductase involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD 326629 TRR2 856506 TRR2 Saccharomyces cerevisiae Mitochondrial thioredoxin reductase involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD NP_011974.1 325601 D 4932 CDS NP_011975.1 6321899 856507 complement(326816..328039) 1 NC_001140.5 Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM; Cdc12p 328039 CDC12 856507 CDC12 Saccharomyces cerevisiae Cdc12p NP_011975.1 326816 R 4932 CDS NP_011976.1 6321900 856508 328306..330063 1 NC_001140.5 Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi; Gga2p 330063 GGA2 856508 GGA2 Saccharomyces cerevisiae Gga2p NP_011976.1 328306 D 4932 CDS NP_011977.1 6321901 856509 330313..332070 1 NC_001140.5 Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth; Ctm1p 332070 CTM1 856509 CTM1 Saccharomyces cerevisiae Ctm1p NP_011977.1 330313 D 4932 CDS NP_011978.1 6321902 856510 332285..332923 1 NC_001140.5 Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport; Erp5p 332923 ERP5 856510 ERP5 Saccharomyces cerevisiae Erp5p NP_011978.1 332285 D 4932 CDS NP_011979.1 6321903 856511 333075..334397 1 NC_001140.5 Uba4p; Protein that activates Urm1p before its conjugation to proteins (urmylation); one target is the thioredoxin peroxidase Ahp1p, suggesting a role of urmylation in the oxidative stress response 334397 UBA4 856511 UBA4 Saccharomyces cerevisiae Protein that activates Urm1p before its conjugation to proteins (urmylation); one target is the thioredoxin peroxidase Ahp1p, suggesting a role of urmylation in the oxidative stress response NP_011979.1 333075 D 4932 CDS NP_011980.1 6321904 856512 complement(334530..335666) 1 NC_001140.5 Yhr112cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 335666 856512 YHR112C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm NP_011980.1 334530 R 4932 CDS NP_011981.1 6321905 856513 336340..337812 1 NC_001140.5 Yhr113wp; Cytoplasmic aspartyl aminopeptidase; cleaves unblocked N-terminal acidic amino acid residues from peptide substrates; forms a 12 subunit homo-oligomeric complex; M18 metalloprotease family member; may interact with ribosomes 337812 856513 YHR113W Saccharomyces cerevisiae Cytoplasmic aspartyl aminopeptidase; cleaves unblocked N-terminal acidic amino acid residues from peptide substrates; forms a 12 subunit homo-oligomeric complex; M18 metalloprotease family member; may interact with ribosomes NP_011981.1 336340 D 4932 CDS NP_011982.1 6321906 856514 338086..339987 1 NC_001140.5 SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins; Bzz1p 339987 BZZ1 856514 BZZ1 Saccharomyces cerevisiae Bzz1p NP_011982.1 338086 D 4932 CDS NP_011983.1 6321907 856515 complement(340112..341362) 1 NC_001140.5 Protein involved in regulating spindle position and orientation, functionally redundant with Dma2p; homolog of S. pombe Dma1 and H. sapiens Chfr; Dma1p 341362 DMA1 856515 DMA1 Saccharomyces cerevisiae Dma1p NP_011983.1 340112 R 4932 CDS NP_011984.1 6321908 856516 341668..342123 1 NC_001140.5 Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; Cox23p 342123 COX23 856516 COX23 Saccharomyces cerevisiae Cox23p NP_011984.1 341668 D 4932 CDS NP_011985.1 6321909 856517 342352..344271 1 NC_001140.5 Tom71p; Mitochondrial outer membrane protein with similarity to Tom70p; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins 344271 TOM71 856517 TOM71 Saccharomyces cerevisiae Mitochondrial outer membrane protein with similarity to Tom70p; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins NP_011985.1 342352 D 4932 CDS NP_011986.1 6321910 856518 complement(344324..345631) 1 NC_001140.5 Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p; Orc6p 345631 ORC6 856518 ORC6 Saccharomyces cerevisiae Orc6p NP_011986.1 344324 R 4932 CDS NP_011987.1 6321911 856519 346046..349288 1 NC_001140.5 Set1p; Histone methyltransferase, subunit of the COMPASS (Set1C) complex which methylates histone H3 on lysine 4; required in transcriptional silencing near telomeres and at the silent mating type loci; contains a SET domain 349288 SET1 856519 SET1 Saccharomyces cerevisiae Histone methyltransferase, subunit of the COMPASS (Set1C) complex which methylates histone H3 on lysine 4; required in transcriptional silencing near telomeres and at the silent mating type loci; contains a SET domain NP_011987.1 346046 D 4932 CDS NP_011988.1 6321912 856520 349577..352456 1 NC_001140.5 Msh1p; DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis 352456 MSH1 856520 MSH1 Saccharomyces cerevisiae DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis NP_011988.1 349577 D 4932 CDS NP_011989.1 6321913 856521 352759..353322 1 NC_001140.5 Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS; Lsm12p 353322 LSM12 856521 LSM12 Saccharomyces cerevisiae Lsm12p NP_011989.1 352759 D 4932 CDS NP_011990.1 6321914 856522 353628..354323 1 NC_001140.5 Yhr122wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; may be involved in transcription; YHR122W is an essential gene 354323 856522 YHR122W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; may be involved in transcription; YHR122W is an essential gene NP_011990.1 353628 D 4932 CDS NP_011991.1 6321915 856523 join(354818..354867,354959..356084) 1 NC_001140.5 sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability; Ept1p 356084 EPT1 856523 EPT1 Saccharomyces cerevisiae Ept1p NP_011991.1 354818 D 4932 CDS NP_011992.1 6321916 856524 356564..358447 1 NC_001140.5 Ndt80p; Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE) 358447 NDT80 856524 NDT80 Saccharomyces cerevisiae Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE) NP_011992.1 356564 D 4932 CDS NP_011994.1 6321918 856527 complement(359705..360184) 1 NC_001140.5 Yhr126cp; Putative protein of unknown function; transcription dependent upon Azf1p 360184 856527 YHR126C Saccharomyces cerevisiae Putative protein of unknown function; transcription dependent upon Azf1p NP_011994.1 359705 R 4932 CDS NP_011995.1 6321919 856528 360916..361647 1 NC_001140.5 Yhr127wp; Protein of unknown function; localizes to the nucleus 361647 856528 YHR127W Saccharomyces cerevisiae Protein of unknown function; localizes to the nucleus NP_011995.1 360916 D 4932 CDS NP_011996.2 37362660 856529 362118..362768 1 NC_001140.5 Uracil phosphoribosyltransferase, synthesizes UMP from uracil; involved in the pyrimidine salvage pathway; Fur1p 362768 FUR1 856529 FUR1 Saccharomyces cerevisiae Fur1p NP_011996.2 362118 D 4932 CDS NP_011997.1 6321921 856530 complement(363002..364156) 1 NC_001140.5 Arp1p; Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin 364156 ARP1 856530 ARP1 Saccharomyces cerevisiae Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin NP_011997.1 363002 R 4932 CDS NP_011999.2 50882584 856532 complement(365343..367895) 1 NC_001140.5 Yhr131cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 367895 856532 YHR131C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm NP_011999.2 365343 R 4932 CDS NP_012000.1 6321924 856533 complement(368505..369797) 1 NC_001140.5 Putative metalloprotease with similarity to the zinc carboxypeptidase family, required for normal cell wall assembly; Ecm14p 369797 ECM14 856533 ECM14 Saccharomyces cerevisiae Ecm14p NP_012000.1 368505 R 4932 CDS NP_036194.1 6862571 856534 370057..370452 1 NC_001140.5 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; Igo2p 370452 IGO2 856534 IGO2 Saccharomyces cerevisiae Igo2p NP_036194.1 370057 D 4932 CDS NP_012001.1 6321925 856535 complement(370725..371600) 1 NC_001140.5 Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins; Nsg1p 371600 NSG1 856535 NSG1 Saccharomyces cerevisiae Nsg1p NP_012001.1 370725 R 4932 CDS NP_012002.1 6321926 856536 371752..372561 1 NC_001140.5 Wss1p; Sumoylated protein of unknown function, identified based on genetic interactions with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response, processing stalled or collapsed replication forks 372561 WSS1 856536 WSS1 Saccharomyces cerevisiae Sumoylated protein of unknown function, identified based on genetic interactions with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response, processing stalled or collapsed replication forks NP_012002.1 371752 D 4932 CDS NP_012003.1 6321927 856537 complement(372697..374313) 1 NC_001140.5 Yck1p; Palmitoylated, plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck2p 374313 YCK1 856537 YCK1 Saccharomyces cerevisiae Palmitoylated, plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck2p NP_012003.1 372697 R 4932 CDS NP_012004.1 6321928 856538 complement(374657..375103) 1 NC_001140.5 Spl2p; Protein with similarity to cyclin-dependent kinase inhibitors, overproduction suppresses a plc1 null mutation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 375103 SPL2 856538 SPL2 Saccharomyces cerevisiae Protein with similarity to cyclin-dependent kinase inhibitors, overproduction suppresses a plc1 null mutation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern NP_012004.1 374657 R 4932 CDS NP_012005.1 6321929 856539 375712..377253 1 NC_001140.5 Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism; Aro9p 377253 ARO9 856539 ARO9 Saccharomyces cerevisiae Aro9p NP_012005.1 375712 D 4932 CDS NP_012006.1 6321930 856540 complement(377358..377702) 1 NC_001140.5 Yhr138cp; Putative protein of unknown function; has similarity to Pbi2p; double null mutant lacking Pbi2p and Yhr138p exhibits highly fragmented vacuoles 377702 856540 YHR138C Saccharomyces cerevisiae Putative protein of unknown function; has similarity to Pbi2p; double null mutant lacking Pbi2p and Yhr138p exhibits highly fragmented vacuoles NP_012006.1 377358 R 4932 CDS NP_012007.1 6321931 856541 complement(378222..379202) 1 NC_001140.5 Sps100p; Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall 379202 SPS100 856541 SPS100 Saccharomyces cerevisiae Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall NP_012007.1 378222 R 4932 CDS NP_012009.1 6321933 856543 380575..381294 1 NC_001140.5 Yhr140wp; Putative integral membrane protein of unknown function 381294 856543 YHR140W Saccharomyces cerevisiae Putative integral membrane protein of unknown function NP_012009.1 380575 D 4932 CDS NP_012010.1 6321934 856544 complement(join(381993..382309,382751..382754)) 1 NC_001140.5 Rpl42bp; Protein component of the large (60S) ribosomal subunit, identical to Rpl42Ap and has similarity to rat L44; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus 382754 RPL42B 856544 RPL42B Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, identical to Rpl42Ap and has similarity to rat L44; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus NP_012010.1 381993 R 4932 CDS NP_012011.1 6321935 856545 383541..384491 1 NC_001140.5 Protein of unknown function, involved in chitin biosynthesis by regulating Chs3p export from the ER; Chs7p 384491 CHS7 856545 CHS7 Saccharomyces cerevisiae Chs7p NP_012011.1 383541 D 4932 CDS NP_012012.1 6321936 856546 385513..386490 1 NC_001140.5 Dse2p; Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP 386490 DSE2 856546 DSE2 Saccharomyces cerevisiae Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP NP_012012.1 385513 D 4932 CDS NP_012013.1 6321937 856547 387236..387448 1 NC_001140.5 Rpc10p; RNA polymerase subunit, found in RNA polymerase complexes I, II, and III 387448 RPC10 856547 RPC10 Saccharomyces cerevisiae RNA polymerase subunit, found in RNA polymerase complexes I, II, and III NP_012013.1 387236 D 4932 CDS NP_012014.1 6321938 856548 complement(387791..388729) 1 NC_001140.5 Deoxycytidine monophosphate (dCMP) deaminase required for dCTP and dTTP synthesis; expression is NOT cell cycle regulated; Dcd1p 388729 DCD1 856548 DCD1 Saccharomyces cerevisiae Dcd1p NP_012014.1 387791 R 4932 CDS NP_012016.1 6321940 856551 390303..391700 1 NC_001140.5 Protein that binds to cruciform DNA structures; Crp1p 391700 CRP1 856551 CRP1 Saccharomyces cerevisiae Crp1p NP_012016.1 390303 D 4932 CDS NP_012017.1 6321941 856552 complement(392642..393286) 1 NC_001140.5 Mrpl6p; Mitochondrial ribosomal protein of the large subunit 393286 MRPL6 856552 MRPL6 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit NP_012017.1 392642 R 4932 CDS NP_012018.1 6321942 856553 393537..394088 1 NC_001140.5 Imp3p; Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA 394088 IMP3 856553 IMP3 Saccharomyces cerevisiae Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA NP_012018.1 393537 D 4932 CDS NP_012019.1 6321943 856554 complement(394458..396662) 1 NC_001140.5 Skg6p; Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p 396662 SKG6 856554 SKG6 Saccharomyces cerevisiae Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p NP_012019.1 394458 R 4932 CDS NP_012020.1 6321944 856555 397254..398993 1 NC_001140.5 Pex28p; Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p 398993 PEX28 856555 PEX28 Saccharomyces cerevisiae Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p NP_012020.1 397254 D 4932 CDS NP_012021.1 6321945 856556 complement(399271..400851) 1 NC_001140.5 Yhr151cp; Putative protein of unknown function 400851 856556 YHR151C Saccharomyces cerevisiae Putative protein of unknown function NP_012021.1 399271 R 4932 CDS NP_012022.1 6321946 856557 401437..401958 1 NC_001140.5 Spo12p; Nucleolar protein of unknown function, positive regulator of exit from mitosis; involved in regulating the release of Cdc14p from the nucleolus in early anaphase; proposed to play similar role in meiosis 401958 SPO12 856557 SPO12 Saccharomyces cerevisiae Nucleolar protein of unknown function, positive regulator of exit from mitosis; involved in regulating the release of Cdc14p from the nucleolus in early anaphase; proposed to play similar role in meiosis NP_012022.1 401437 D 4932 CDS NP_012023.1 6321947 856558 complement(402089..402685) 1 NC_001140.5 Spo16p; Protein of unknown function, required for spore formation 402685 SPO16 856558 SPO16 Saccharomyces cerevisiae Protein of unknown function, required for spore formation NP_012023.1 402089 R 4932 CDS NP_012024.1 6321948 856559 402969..406181 1 NC_001140.5 Rtt107p; Protein implicated in Mms22-dependent DNA repair during S phase, DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition 406181 RTT107 856559 RTT107 Saccharomyces cerevisiae Protein implicated in Mms22-dependent DNA repair during S phase, DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition NP_012024.1 402969 D 4932 CDS NP_012025.1 6321949 856560 407106..410792 1 NC_001140.5 Ysp1p; Mitochondrial protein with a potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone 410792 YSP1 856560 YSP1 Saccharomyces cerevisiae Mitochondrial protein with a potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone NP_012025.1 407106 D 4932 CDS NP_012026.1 6321950 856561 complement(411387..412409) 1 NC_001140.5 Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication; Lin1p 412409 LIN1 856561 LIN1 Saccharomyces cerevisiae Lin1p NP_012026.1 411387 R 4932 CDS NP_012027.1 6321951 856562 412910..413458 1 NC_001140.5 Rec104p; Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination 413458 REC104 856562 REC104 Saccharomyces cerevisiae Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination NP_012027.1 412910 D 4932 CDS NP_012028.1 6321952 856563 complement(413688..417182) 1 NC_001140.5 Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate; Kel1p 417182 KEL1 856563 KEL1 Saccharomyces cerevisiae Kel1p NP_012028.1 413688 R 4932 CDS NP_012029.1 6321953 856564 417552..419066 1 NC_001140.5 Yhr159wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; potential Cdc28p substrate 419066 856564 YHR159W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; potential Cdc28p substrate NP_012029.1 417552 D 4932 CDS NP_012030.1 6321954 856565 complement(419224..420075) 1 NC_001140.5 Pex18p; Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p 420075 PEX18 856565 PEX18 Saccharomyces cerevisiae Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p NP_012030.1 419224 R 4932 CDS NP_012031.1 6321955 856566 complement(420376..422289) 1 NC_001140.5 Yap1801p; Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1802p, member of the AP180 protein family 422289 YAP1801 856566 YAP1801 Saccharomyces cerevisiae Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1802p, member of the AP180 protein family NP_012031.1 420376 R 4932 CDS NP_012032.1 6321956 856567 423075..423464 1 NC_001140.5 Yhr162wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion 423464 856567 YHR162W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion NP_012032.1 423075 D 4932 CDS NP_012033.2 82795254 856568 423726..424475 1 NC_001140.5 Sol3p; 6-phosphogluconolactonase, catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p 424475 SOL3 856568 SOL3 Saccharomyces cerevisiae 6-phosphogluconolactonase, catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p NP_012033.2 423726 D 4932 CDS NP_012034.1 6321958 856569 complement(424612..429180) 1 NC_001140.5 Essential tripartite DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair pathways; potential Cdc28p substrate; Dna2p 429180 DNA2 856569 DNA2 Saccharomyces cerevisiae Dna2p NP_012034.1 424612 R 4932 CDS NP_012035.1 6321959 856570 complement(429709..436950) 1 NC_001140.5 Prp8p; Component of the U4/U6-U5 snRNP complex, involved in the second catalytic step of splicing; mutations of human Prp8 cause retinitis pigmentosa 436950 PRP8 856570 PRP8 Saccharomyces cerevisiae Component of the U4/U6-U5 snRNP complex, involved in the second catalytic step of splicing; mutations of human Prp8 cause retinitis pigmentosa NP_012035.1 429709 R 4932 CDS NP_012036.1 6321960 856571 complement(437172..439052) 1 NC_001140.5 Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; Cdc23p 439052 CDC23 856571 CDC23 Saccharomyces cerevisiae Cdc23p NP_012036.1 437172 R 4932 CDS NP_012037.1 6321961 856572 439344..440129 1 NC_001140.5 Thp2p; Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance 440129 THP2 856572 THP2 Saccharomyces cerevisiae Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance NP_012037.1 439344 D 4932 CDS NP_012038.1 6321962 856573 440379..441878 1 NC_001140.5 Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly; Mtg2p 441878 MTG2 856573 MTG2 Saccharomyces cerevisiae Mtg2p NP_012038.1 440379 D 4932 CDS NP_012039.1 6321963 856574 442182..443477 1 NC_001140.5 Putative ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 40S ribosomal subunit; Dbp8p 443477 DBP8 856574 DBP8 Saccharomyces cerevisiae Dbp8p NP_012039.1 442182 D 4932 CDS NP_012040.1 6321964 856575 443829..445385 1 NC_001140.5 Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex; Nmd3p 445385 NMD3 856575 NMD3 Saccharomyces cerevisiae Nmd3p NP_012040.1 443829 D 4932 CDS NP_012041.1 6321965 856576 445713..447605 1 NC_001140.5 Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation; Atg7p 447605 ATG7 856576 ATG7 Saccharomyces cerevisiae Atg7p NP_012041.1 445713 D 4932 CDS NP_012042.1 6321966 856577 448335..450806 1 NC_001140.5 Spc97p; Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque 450806 SPC97 856577 SPC97 Saccharomyces cerevisiae Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque NP_012042.1 448335 D 4932 CDS NP_012044.1 6321968 856579 451327..452640 1 NC_001140.5 Enolase II, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is induced in response to glucose; Eno2p 452640 ENO2 856579 ENO2 Saccharomyces cerevisiae Eno2p NP_012044.1 451327 D 4932 CDS NP_012045.1 6321969 856580 452872..453441 1 NC_001140.5 Putative low-affinity copper transporter of the vacuolar membrane; mutation confers resistance to toxic copper concentrations, while overexpression confers resistance to copper starvation; Ctr2p 453441 CTR2 856580 CTR2 Saccharomyces cerevisiae Ctr2p NP_012045.1 452872 D 4932 CDS NP_878090.1 33438808 1466530 453558..453707 1 NC_001140.5 Yhr175w-ap; Putative protein of unknown function; identified by fungal homology and RT-PCR 453707 1466530 YHR175W-A Saccharomyces cerevisiae Putative protein of unknown function; identified by fungal homology and RT-PCR NP_878090.1 453558 D 4932 CDS NP_012046.2 41629686 856581 454229..455527 1 NC_001140.5 Fmo1p; Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins 455527 FMO1 856581 FMO1 Saccharomyces cerevisiae Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins NP_012046.2 454229 D 4932 CDS NP_012047.1 6321971 856582 456591..457952 1 NC_001140.5 Yhr177wp; Putative protein of unknown function 457952 856582 YHR177W Saccharomyces cerevisiae Putative protein of unknown function NP_012047.1 456591 D 4932 CDS NP_012048.1 6321972 856583 459299..461530 1 NC_001140.5 Stb5p; Activator of multidrug resistance genes, forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a PDRE (pleotropic drug resistance element) in vitro; binds Sin3p in a two-hybrid assay 461530 STB5 856583 STB5 Saccharomyces cerevisiae Activator of multidrug resistance genes, forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a PDRE (pleotropic drug resistance element) in vitro; binds Sin3p in a two-hybrid assay NP_012048.1 459299 D 4932 CDS NP_012049.1 6321973 856584 462502..463704 1 NC_001140.5 Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye3p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism; Oye2p 463704 OYE2 856584 OYE2 Saccharomyces cerevisiae Oye2p NP_012049.1 462502 D 4932 CDS NP_012051.1 6321975 856587 467228..467914 1 NC_001140.5 Svp26p; Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment 467914 SVP26 856587 SVP26 Saccharomyces cerevisiae Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment NP_012051.1 467228 D 4932 CDS NP_012052.1 6321976 856588 468219..470576 1 NC_001140.5 Yhr182wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm 470576 856588 YHR182W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm NP_012052.1 468219 D 4932 CDS NP_012053.1 6321977 856589 470960..472429 1 NC_001140.5 Gnd1p; 6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress 472429 GND1 856589 GND1 Saccharomyces cerevisiae 6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress NP_012053.1 470960 D 4932 CDS NP_012054.1 6321978 856590 472744..474459 1 NC_001140.5 Ssp1p; Protein involved in the control of meiotic nuclear division and coordination of meiosis with spore formation; transcription is induced midway through meiosis 474459 SSP1 856590 SSP1 Saccharomyces cerevisiae Protein involved in the control of meiotic nuclear division and coordination of meiosis with spore formation; transcription is induced midway through meiosis NP_012054.1 472744 D 4932 CDS NP_012055.1 6321979 856591 complement(474627..475340) 1 NC_001140.5 Sporulation protein required for prospore membrane formation at selected spindle poles, ensures functionality of all four spindle pole bodies during meiosis II; not required for meiotic recombination or meiotic chromosome segregation; Pfs1p 475340 PFS1 856591 PFS1 Saccharomyces cerevisiae Pfs1p NP_012055.1 474627 R 4932 CDS NP_012056.1 6321980 856593 complement(475999..480672) 1 NC_001140.5 Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors; Kog1p 480672 KOG1 856593 KOG1 Saccharomyces cerevisiae Kog1p NP_012056.1 475999 R 4932 CDS NP_012057.1 6321981 856594 480990..481919 1 NC_001140.5 Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin; Iki1p 481919 IKI1 856594 IKI1 Saccharomyces cerevisiae Iki1p NP_012057.1 480990 D 4932 CDS NP_012058.1 6321982 856595 complement(482005..483837) 1 NC_001140.5 Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog; Gpi16p 483837 GPI16 856595 GPI16 Saccharomyces cerevisiae Gpi16p NP_012058.1 482005 R 4932 CDS NP_012059.1 6321983 856596 484028..484600 1 NC_001140.5 Pth1p; One of two (see also PTH2) mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for cell growth and for mitochondrial respiration 484600 PTH1 856596 PTH1 Saccharomyces cerevisiae One of two (see also PTH2) mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for cell growth and for mitochondrial respiration NP_012059.1 484028 D 4932 CDS NP_012060.1 6321984 856597 484845..486179 1 NC_001140.5 Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway; Erg9p 486179 ERG9 856597 ERG9 Saccharomyces cerevisiae Erg9p NP_012060.1 484845 D 4932 CDS NP_012061.1 6321985 856598 complement(486230..486631) 1 NC_001140.5 Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; Ctf8p 486631 CTF8 856598 CTF8 Saccharomyces cerevisiae Ctf8p NP_012061.1 486230 R 4932 CDS NP_012062.1 6321986 856599 486826..487662 1 NC_001140.5 Yhr192wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS 487662 856599 YHR192W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS NP_012062.1 486826 D 4932 CDS NP_012063.1 6321987 856600 complement(487712..488236) 1 NC_001140.5 Egd2p; Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes 488236 EGD2 856600 EGD2 Saccharomyces cerevisiae Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes NP_012063.1 487712 R 4932 CDS NP_012064.1 6321988 856601 488657..490396 1 NC_001140.5 Mitochondrial inner membrane protein with similarity to Mdm32p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34; Mdm31p 490396 MDM31 856601 MDM31 Saccharomyces cerevisiae Mdm31p NP_012064.1 488657 D 4932 CDS NP_012065.1 6321989 856602 490747..491712 1 NC_001140.5 Nvj1p; Nuclear envelope protein that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN) 491712 NVJ1 856602 NVJ1 Saccharomyces cerevisiae Nuclear envelope protein that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN) NP_012065.1 490747 D 4932 CDS NP_012066.1 6321990 856603 491931..493658 1 NC_001140.5 Utp9p; Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA 493658 UTP9 856603 UTP9 Saccharomyces cerevisiae Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA NP_012066.1 491931 D 4932 CDS NP_012067.1 6321991 856604 493896..496187 1 NC_001140.5 Rix1p; Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles 496187 RIX1 856604 RIX1 Saccharomyces cerevisiae Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles NP_012067.1 493896 D 4932 CDS NP_012068.1 6321992 856605 complement(496315..497280) 1 NC_001140.5 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays increased frequency of mitochondrial genome loss (petite formation); Aim18p 497280 AIM18 856605 AIM18 Saccharomyces cerevisiae Aim18p NP_012068.1 496315 R 4932 CDS NP_012069.1 6321993 856606 complement(497490..498422) 1 NC_001140.5 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays increased frequency of mitochondrial genome loss (petite formation); Aim46p 498422 AIM46 856606 AIM46 Saccharomyces cerevisiae Aim46p NP_012069.1 497490 R 4932 CDS NP_976247.1 42759857 2746858 complement(join(498571..498719,498787..498859)) 1 NC_001140.5 Yhr199c-ap; Putative protein of unknown function; transcribed sequence appears to contain an intron 498859 2746858 YHR199C-A Saccharomyces cerevisiae Putative protein of unknown function; transcribed sequence appears to contain an intron NP_976247.1 498571 R 4932 CDS NP_012070.1 6321994 856607 499079..499885 1 NC_001140.5 Rpn10p; Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein 499885 RPN10 856607 RPN10 Saccharomyces cerevisiae Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein NP_012070.1 499079 D 4932 CDS NP_012071.1 6321995 856608 complement(499950..501143) 1 NC_001140.5 Ppx1p; Exopolyphosphatase, hydrolyzes inorganic polyphosphate (poly P) into Pi residues; located in the cytosol, plasma membrane, and mitochondrial matrix 501143 PPX1 856608 PPX1 Saccharomyces cerevisiae Exopolyphosphatase, hydrolyzes inorganic polyphosphate (poly P) into Pi residues; located in the cytosol, plasma membrane, and mitochondrial matrix NP_012071.1 499950 R 4932 CDS NP_012072.1 6321996 856609 502388..504196 1 NC_001140.5 Yhr202wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization 504196 856609 YHR202W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization NP_012072.1 502388 D 4932 CDS NP_012073.1 6321997 856610 complement(join(504476..505247,505517..505530)) 1 NC_001140.5 Rps4bp; Protein component of the small (40S) ribosomal subunit; identical to Rps4Ap and has similarity to rat S4 ribosomal protein 505530 RPS4B 856610 RPS4B Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit; identical to Rps4Ap and has similarity to rat S4 ribosomal protein NP_012073.1 504476 R 4932 CDS NP_012074.1 6321998 856611 506319..508709 1 NC_001140.5 Mnl1p; Alpha mannosidase-like protein of the endoplasmic reticulum required for degradation of glycoproteins but not for processing of N-linked oligosaccharides 508709 MNL1 856611 MNL1 Saccharomyces cerevisiae Alpha mannosidase-like protein of the endoplasmic reticulum required for degradation of glycoproteins but not for processing of N-linked oligosaccharides NP_012074.1 506319 D 4932 CDS NP_012075.1 6321999 856612 509363..511837 1 NC_001140.5 Sch9p; Protein kinase involved in transcriptional activation of osmostress-responsive genes; regulates G1 progression, cAPK activity, nitrogen activation of the FGM pathway; involved in life span regulation; homologous to mammalian Akt/PKB 511837 SCH9 856612 SCH9 Saccharomyces cerevisiae Protein kinase involved in transcriptional activation of osmostress-responsive genes; regulates G1 progression, cAPK activity, nitrogen activation of the FGM pathway; involved in life span regulation; homologous to mammalian Akt/PKB NP_012075.1 509363 D 4932 CDS NP_012076.1 6322000 856613 512732..514600 1 NC_001140.5 Skn7p; Nuclear response regulator and transcription factor, part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation 514600 SKN7 856613 SKN7 Saccharomyces cerevisiae Nuclear response regulator and transcription factor, part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation NP_012076.1 512732 D 4932 CDS NP_012077.1 6322001 856614 complement(514905..516485) 1 NC_001140.5 Zinc-finger protein of unknown function, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus; Set5p 516485 SET5 856614 SET5 Saccharomyces cerevisiae Set5p NP_012077.1 514905 R 4932 CDS NP_012078.1 6322002 856615 517532..518713 1 NC_001140.5 Mitochondrial branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during logarithmic phase and repressed during stationary phase; Bat1p 518713 BAT1 856615 BAT1 Saccharomyces cerevisiae Bat1p NP_012078.1 517532 D 4932 CDS NP_012079.1 6322003 856616 519437..520312 1 NC_001140.5 Putative S-adenosylmethionine-dependent methyltransferase; mediates cantharidin resistance; Crg1p 520312 CRG1 856616 CRG1 Saccharomyces cerevisiae Crg1p NP_012079.1 519437 D 4932 CDS NP_012080.1 6322004 856617 complement(520712..521737) 1 NC_001140.5 Yhr210cp; Putative protein of unknown function; non-essential gene; highly expressed under anaeorbic conditions; sequence similarity to aldose 1-epimerases such as GAL10 521737 856617 YHR210C Saccharomyces cerevisiae Putative protein of unknown function; non-essential gene; highly expressed under anaeorbic conditions; sequence similarity to aldose 1-epimerases such as GAL10 NP_012080.1 520712 R 4932 CDS NP_012081.1 6322005 856618 525392..528619 1 NC_001140.5 Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p; Flo5p 528619 FLO5 856618 FLO5 Saccharomyces cerevisiae Flo5p NP_012081.1 525392 D 4932 CDS NP_878091.1 33438809 1466531 538742..538945 1 NC_001140.5 Yhr212w-ap; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 538945 1466531 YHR212W-A Saccharomyces cerevisiae Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching NP_878091.1 538742 D 4932 CDS NP_012083.1 6322007 856620 539151..539747 1 NC_001140.5 Yhr213wp; Putative protein of unknown function 539747 856620 YHR213W Saccharomyces cerevisiae Putative protein of unknown function NP_012083.1 539151 D 4932 CDS NP_878092.1 33438810 1466532 540549..540782 1 NC_001140.5 Yhr213w-ap; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 540782 1466532 YHR213W-A Saccharomyces cerevisiae Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching NP_878092.1 540549 D 4932 CDS NP_878093.1 33438811 1466533 540800..541099 1 NC_001140.5 Yhr213w-bp; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 541099 1466533 YHR213W-B Saccharomyces cerevisiae Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching NP_878093.1 540800 D 4932 CDS NP_012084.1 6322008 856621 541651..542262 1 NC_001140.5 Yhr214wp; Putative protein of unknown function; predicted to be a glycosylphosphatidylinositol-modified (GPI) protein 542262 856621 YHR214W Saccharomyces cerevisiae Putative protein of unknown function; predicted to be a glycosylphosphatidylinositol-modified (GPI) protein NP_012084.1 541651 D 4932 CDS NP_012086.1 6322010 856623 complement(join(543964..547929,547931..549346)) 1 NC_001140.5 Yhr214c-bp; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 549346 856623 YHR214C-B Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_012086.1 543964 R 4932 CDS NP_036195.1 6862572 856624 complement(547910..549346) 1 NC_001140.5 Yhr214c-cp; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 549346 856624 YHR214C-C Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_036195.1 547910 R 4932 CDS NP_878094.1 33438812 1466534 complement(550648..550941) 1 NC_001140.5 Yhr214c-dp; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 550941 1466534 YHR214C-D Saccharomyces cerevisiae Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching NP_878094.1 550648 R 4932 CDS NP_878095.1 33438813 1466535 complement(551200..551499) 1 NC_001140.5 Yhr214c-ep; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 551499 1466535 YHR214C-E Saccharomyces cerevisiae Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching NP_878095.1 551200 R 4932 CDS NP_012087.1 6322011 856625 552099..553502 1 NC_001140.5 Pho12p; One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway; nearly identical to Pho11p; upregulated by phosphate starvation 553502 PHO12 856625 PHO12 Saccharomyces cerevisiae One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway; nearly identical to Pho11p; upregulated by phosphate starvation NP_012087.1 552099 D 4932 CDS NP_012088.1 6322012 856626 554396..555967 1 NC_001140.5 Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation; Imd2p 555967 IMD2 856626 IMD2 Saccharomyces cerevisiae Imd2p NP_012088.1 554396 D 4932 CDS NP_012090.1 6322014 856628 join(558014..558615,558715..559924) 1 NC_001140.5 Yhr218wp; Helicase-like protein encoded within the telomeric Y' element 559924 856628 YHR218W Saccharomyces cerevisiae Helicase-like protein encoded within the telomeric Y' element NP_012090.1 558014 D 4932 CDS NP_012091.1 6322015 856629 560173..562047 1 NC_001140.5 Yhr219wp; Putative protein of unknown function with similarity to helicases; located in the telomere region on the right arm of chromosome VIII 562047 856629 YHR219W Saccharomyces cerevisiae Putative protein of unknown function with similarity to helicases; located in the telomere region on the right arm of chromosome VIII NP_012091.1 560173 D 4932 CDS NP_012311.1 6322237 853231 complement(join(466..4581,4970..6130)) 1 NC_001142.7 Yjl225cp; Putative protein of unknown function; similarity to DNA helicases that are also encoded within subtelomeric Y' elements and induced in telomerase deficient survivors 6130 853231 YJL225C Saccharomyces cerevisiae Putative protein of unknown function; similarity to DNA helicases that are also encoded within subtelomeric Y' elements and induced in telomerase deficient survivors NP_012311.1 466 R 4932 CDS NP_012312.1 6322238 853232 complement(8776..9138) 1 NC_001142.7 Pau1p; Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme 9138 PAU1 853232 PAU1 Saccharomyces cerevisiae Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme NP_012312.1 8776 R 4932 CDS NP_012313.1 6322239 853233 11475..16124 1 NC_001142.7 Vth2p; Putative membrane glycoprotein with strong similarity to Vth1p and Pep1p/Vps10p, may be involved in vacuolar protein sorting 16124 VTH2 853233 VTH2 Saccharomyces cerevisiae Putative membrane glycoprotein with strong similarity to Vth1p and Pep1p/Vps10p, may be involved in vacuolar protein sorting NP_012313.1 11475 D 4932 CDS NP_012314.1 6322241 853235 complement(16767..18536) 1 NC_001142.7 Protein of unknown function, expression is induced during nitrogen limitation; Fsp2p 18536 FSP2 853235 FSP2 Saccharomyces cerevisiae Fsp2p NP_012314.1 16767 R 4932 CDS NP_012316.1 6322242 853236 19497..21200 1 NC_001142.7 Putative hexose transporter that is nearly identical to Hxt11p, has similarity to major facilitator superfamily (MFS) transporters, expression of HXT9 is regulated by transcription factors Pdr1p and Pdr3p; Hxt9p 21200 HXT9 853236 HXT9 Saccharomyces cerevisiae Hxt9p NP_012316.1 19497 D 4932 CDS NP_012317.1 6322243 853237 21973..22563 1 NC_001142.7 Yjl218wp; Putative protein of unknown function, similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene 22563 853237 YJL218W Saccharomyces cerevisiae Putative protein of unknown function, similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene NP_012317.1 21973 D 4932 CDS NP_012318.1 6322244 853238 23133..23729 1 NC_001142.7 Yjl217wp; Cytoplasmic protein of unknown function; expression induced by calcium shortage and via the copper sensing transciption factor Mac1p during conditons of copper deficiency; mRNA is cell cycle regulated, peaking in G1 phase 23729 853238 YJL217W Saccharomyces cerevisiae Cytoplasmic protein of unknown function; expression induced by calcium shortage and via the copper sensing transciption factor Mac1p during conditons of copper deficiency; mRNA is cell cycle regulated, peaking in G1 phase NP_012318.1 23133 D 4932 CDS NP_012319.1 6322245 853214 complement(24341..26086) 1 NC_001142.7 Yjl216cp; Protein of unknown function, similar to alpha-D-glucosidases; transcriptionally activated by both Pdr8p and Yrm1p, along with transporters and other genes involved in the pleiotropic drug resistance (PDR) phenomenon 26086 853214 YJL216C Saccharomyces cerevisiae Protein of unknown function, similar to alpha-D-glucosidases; transcriptionally activated by both Pdr8p and Yrm1p, along with transporters and other genes involved in the pleiotropic drug resistance (PDR) phenomenon NP_012319.1 24341 R 4932 CDS NP_012321.1 6322247 853216 26887..28596 1 NC_001142.7 Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose; Hxt8p 28596 HXT8 853216 HXT8 Saccharomyces cerevisiae Hxt8p NP_012321.1 26887 D 4932 CDS NP_012322.1 6322248 853217 32163..33158 1 NC_001142.7 Yjl213wp; Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p 33158 853217 YJL213W Saccharomyces cerevisiae Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p NP_012322.1 32163 D 4932 CDS NP_012323.1 6322249 853218 complement(33850..36249) 1 NC_001142.7 Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family; Opt1p 36249 OPT1 853218 OPT1 Saccharomyces cerevisiae Opt1p NP_012323.1 33850 R 4932 CDS NP_012325.1 6322250 853219 36919..37734 1 NC_001142.7 RING-finger peroxin, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import; Pex2p 37734 PEX2 853219 PEX2 Saccharomyces cerevisiae Pex2p NP_012325.1 36919 D 4932 CDS NP_012326.1 6322252 853221 38005..39969 1 NC_001142.7 Mitochondrial protein that interacts with the 5'-untranslated region of the COB mRNA and has a role in its stability and translation; found in a complex at the inner membrane along with Pet309p; Cbp1p 39969 CBP1 853221 CBP1 Saccharomyces cerevisiae Cbp1p NP_012326.1 38005 D 4932 CDS NP_012327.1 6322253 853222 complement(40194..41183) 1 NC_001142.7 Nuc1p; Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy 41183 NUC1 853222 NUC1 Saccharomyces cerevisiae Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy NP_012327.1 40194 R 4932 CDS NP_012328.1 6322254 853223 complement(41389..47433) 1 NC_001142.7 Laa1p; AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene 47433 LAA1 853223 LAA1 Saccharomyces cerevisiae AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene NP_012328.1 41389 R 4932 CDS NP_012329.1 6322255 853224 complement(47659..49935) 1 NC_001142.7 Yjl206cp; Putative protein of unknown function; similar to transcriptional regulators from the Zn[2]-Cys[6] binuclear cluster protein family; mRNA is weakly cell cycle regulated, peaking in S phase; induced rapidly upon MMS treatment 49935 853224 YJL206C Saccharomyces cerevisiae Putative protein of unknown function; similar to transcriptional regulators from the Zn[2]-Cys[6] binuclear cluster protein family; mRNA is weakly cell cycle regulated, peaking in S phase; induced rapidly upon MMS treatment NP_012329.1 47659 R 4932 CDS NP_012330.1 6322256 853225 complement(join(50139..50268,50412..50443)) 1 NC_001142.7 Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences; Nce101p 50443 NCE101 853225 NCE101 Saccharomyces cerevisiae Nce101p NP_012330.1 50139 R 4932 CDS NP_012331.1 6322257 853226 complement(50629..53151) 1 NC_001142.7 Rcy1p; F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth 53151 RCY1 853226 RCY1 Saccharomyces cerevisiae F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth NP_012331.1 50629 R 4932 CDS NP_012332.1 6322258 853227 53341..54183 1 NC_001142.7 Subunit of the SF3a splicing factor complex, required for spliceosome assembly; Prp21p 54183 PRP21 853227 PRP21 Saccharomyces cerevisiae Prp21p NP_012332.1 53341 D 4932 CDS NP_012334.1 6322260 853229 54379..56178 1 NC_001142.7 Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p; Ecm25p 56178 ECM25 853229 ECM25 Saccharomyces cerevisiae Ecm25p NP_012334.1 54379 D 4932 CDS NP_012335.1 6322261 853230 complement(56444..58813) 1 NC_001142.7 Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol; Aco2p 58813 ACO2 853230 ACO2 Saccharomyces cerevisiae Aco2p NP_012335.1 56444 R 4932 CDS NP_012337.1 6322263 853241 60843..63488 1 NC_001142.7 Pho90p; Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth 63488 PHO90 853241 PHO90 Saccharomyces cerevisiae Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth NP_012337.1 60843 D 4932 CDS NP_012338.1 6322264 853242 63804..67568 1 NC_001142.7 Ubp12p; Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease present in the nucleus and cytoplasm that cleaves ubiquitin from ubiquitinated proteins 67568 UBP12 853242 UBP12 Saccharomyces cerevisiae Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease present in the nucleus and cytoplasm that cleaves ubiquitin from ubiquitinated proteins NP_012338.1 63804 D 4932 CDS NP_012339.1 6322265 853243 complement(67849..68781) 1 NC_001142.7 Elongase I, medium-chain acyl elongase, catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids; Elo1p 68781 ELO1 853243 ELO1 Saccharomyces cerevisiae Elo1p NP_012339.1 67849 R 4932 CDS NP_012341.1 6322266 853244 69337..70878 1 NC_001142.7 Essential ATP-binding protein required for DNA replication, component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; Cdc6p 70878 CDC6 853244 CDC6 Saccharomyces cerevisiae Cdc6p NP_012341.1 69337 D 4932 CDS NP_012342.1 6322268 853246 71365..72573 1 NC_001142.7 Yjl193wp; Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect 72573 853246 YJL193W Saccharomyces cerevisiae Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect NP_012342.1 71365 D 4932 CDS NP_012343.1 6322269 853247 complement(72709..73413) 1 NC_001142.7 Sop4p; ER-membrane protein; suppressor of pma1-7, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ER 73413 SOP4 853247 SOP4 Saccharomyces cerevisiae ER-membrane protein; suppressor of pma1-7, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ER NP_012343.1 72709 R 4932 CDS NP_012344.1 6322270 853248 join(73786..73795,74204..74610) 1 NC_001142.7 Rps14bp; Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Ap and similar to E. coli S11 and rat S14 ribosomal proteins 74610 RPS14B 853248 RPS14B Saccharomyces cerevisiae Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Ap and similar to E. coli S11 and rat S14 ribosomal proteins NP_012344.1 73786 D 4932 CDS NP_012345.1 6322271 853249 complement(74909..75301) 1 NC_001142.7 Rps22ap; Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Bp and has similarity to E. coli S8 and rat S15a ribosomal proteins 75301 RPS22A 853249 RPS22A Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Bp and has similarity to E. coli S8 and rat S15a ribosomal proteins NP_012345.1 74909 R 4932 CDS NP_012346.1 6322272 853250 join(75932..75937,76324..76473) 1 NC_001142.7 Rpl39p; Protein component of the large (60S) ribosomal subunit, has similarity to rat L39 ribosomal protein; required for ribosome biogenesis; exhibits genetic interactions with SIS1 and PAB1 76473 RPL39 853250 RPL39 Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, has similarity to rat L39 ribosomal protein; required for ribosome biogenesis; exhibits genetic interactions with SIS1 and PAB1 NP_012346.1 75932 D 4932 CDS NP_012348.1 6322274 853252 complement(76802..79261) 1 NC_001142.7 Swe1p; Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate 79261 SWE1 853252 SWE1 Saccharomyces cerevisiae Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate NP_012348.1 76802 R 4932 CDS NP_012349.1 6322275 853253 80153..81913 1 NC_001142.7 Mnn5p; Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment 81913 MNN5 853253 MNN5 Saccharomyces cerevisiae Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment NP_012349.1 80153 D 4932 CDS NP_012350.1 6322276 853254 complement(82093..82974) 1 NC_001142.7 Yjl185cp; Putative protein of unknown function; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene 82974 853254 YJL185C Saccharomyces cerevisiae Putative protein of unknown function; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene NP_012350.1 82093 R 4932 CDS NP_012351.1 6322277 853255 83446..83817 1 NC_001142.7 Protein proposed to be involved in the modification of N-linked oligosaccharides, osmotic stress response, telomere uncapping and elongation, transcription; component of the EKC/KEOPS protein complex with Kae1p, Cgi121p, Pcc1p, and Bud32p; Gon7p 83817 GON7 853255 GON7 Saccharomyces cerevisiae Gon7p NP_012351.1 83446 D 4932 CDS NP_012352.1 6322278 853256 84066..85334 1 NC_001142.7 Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p; Mnn11p 85334 MNN11 853256 MNN11 Saccharomyces cerevisiae Mnn11p NP_012352.1 84066 D 4932 CDS NP_012354.1 6322279 853257 85658..87493 1 NC_001142.7 Yjl181wp; Putative protein of unknown function; expression is cell-cycle regulated as shown by microarray analysis 87493 853257 YJL181W Saccharomyces cerevisiae Putative protein of unknown function; expression is cell-cycle regulated as shown by microarray analysis NP_012354.1 85658 D 4932 CDS NP_012355.1 6322281 853259 complement(87581..88558) 1 NC_001142.7 Conserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency; Atp12p 88558 ATP12 853259 ATP12 Saccharomyces cerevisiae Atp12p NP_012355.1 87581 R 4932 CDS NP_012356.1 6322282 853260 88785..89114 1 NC_001142.7 Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin; Pfd1p 89114 PFD1 853260 PFD1 Saccharomyces cerevisiae Pfd1p NP_012356.1 88785 D 4932 CDS NP_012357.2 42742253 853261 complement(89280..90095) 1 NC_001142.7 Type II membrane protein involved in autophagy; binds phosphatidylinositol 3-phosphate, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; Atg27p 90095 ATG27 853261 ATG27 Saccharomyces cerevisiae Atg27p NP_012357.2 89280 R 4932 CDS NP_012358.1 6322284 853262 join(90784..91092,91410..91655) 1 NC_001142.7 Rpl17bp; Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Ap and has similarity to E. coli L22 and rat L17 ribosomal proteins 91655 RPL17B 853262 RPL17B Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Ap and has similarity to E. coli L22 and rat L17 ribosomal proteins NP_012358.1 90784 D 4932 CDS NP_012359.1 6322286 853264 complement(92051..94528) 1 NC_001142.7 Swi3p; Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2 94528 SWI3 853264 SWI3 Saccharomyces cerevisiae Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2 NP_012359.1 92051 R 4932 CDS NP_012361.1 6322287 853265 95090..95920 1 NC_001142.7 Kre9p; Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects 95920 KRE9 853265 KRE9 Saccharomyces cerevisiae Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects NP_012361.1 95090 D 4932 CDS NP_012362.1 6322288 853266 complement(96159..96527) 1 NC_001142.7 Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; Rfa3p 96527 RFA3 853266 RFA3 Saccharomyces cerevisiae Rfa3p NP_012362.1 96159 R 4932 CDS NP_012363.1 6322289 853267 97731..99461 1 NC_001142.7 Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions; Cps1p 99461 CPS1 853267 CPS1 Saccharomyces cerevisiae Cps1p NP_012363.1 97731 D 4932 CDS NP_012364.1 6322290 853268 complement(99698..100888) 1 NC_001142.7 Yjl171cp; GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein 100888 853268 YJL171C Saccharomyces cerevisiae GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein NP_012364.1 99698 R 4932 CDS NP_012365.2 85666117 853269 complement(101144..101773) 1 NC_001142.7 Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell; specific to a-cells and induced by alpha-factor; Asg7p 101773 ASG7 853269 ASG7 Saccharomyces cerevisiae Asg7p NP_012365.2 101144 R 4932 CDS NP_012367.1 6322293 853271 complement(102221..104422) 1 NC_001142.7 Set2p; Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of histone H3; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p 104422 SET2 853271 SET2 Saccharomyces cerevisiae Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of histone H3; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p NP_012367.1 102221 R 4932 CDS NP_012368.1 6322294 853272 105008..106066 1 NC_001142.7 Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis; Erg20p 106066 ERG20 853272 ERG20 Saccharomyces cerevisiae Erg20p NP_012368.1 105008 D 4932 CDS NP_012369.1 6322295 853273 106428..106712 1 NC_001142.7 Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p; Qcr8p 106712 QCR8 853273 QCR8 Saccharomyces cerevisiae Qcr8p NP_012369.1 106428 D 4932 CDS NP_012370.1 6322296 853274 complement(106888..109455) 1 NC_001142.7 Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; Hal5p 109455 HAL5 853274 HAL5 Saccharomyces cerevisiae Hal5p NP_012370.1 106888 R 4932 CDS NP_012371.1 6322297 853275 complement(109960..111153) 1 NC_001142.7 cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk2p and Tpk3p; Tpk1p 111153 TPK1 853275 TPK1 Saccharomyces cerevisiae Tpk1p NP_012371.1 109960 R 4932 CDS NP_012372.1 6322298 853276 complement(111662..113329) 1 NC_001142.7 Yjl163cp; Putative protein of unknown function 113329 853276 YJL163C Saccharomyces cerevisiae Putative protein of unknown function NP_012372.1 111662 R 4932 CDS NP_012373.2 85666118 853277 complement(113874..115625) 1 NC_001142.7 Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein; Jjj2p 115625 JJJ2 853277 JJJ2 Saccharomyces cerevisiae Jjj2p NP_012373.2 113874 R 4932 CDS NP_012374.1 6322300 853279 117241..117783 1 NC_001142.7 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Fmp33p 117783 FMP33 853279 FMP33 Saccharomyces cerevisiae Fmp33p NP_012374.1 117241 D 4932 CDS NP_012375.2 42742254 853280 complement(117958..118821) 1 NC_001142.7 Yjl160cp; Putative protein of unknown function; member of the PIR (proteins with internal repeats) family of cell wall proteins; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis 118821 853280 YJL160C Saccharomyces cerevisiae Putative protein of unknown function; member of the PIR (proteins with internal repeats) family of cell wall proteins; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis NP_012375.2 117958 R 4932 CDS NP_012376.3 116006493 853281 120445..121686 1 NC_001142.7 O-mannosylated heat shock protein that is secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; Hsp150p 121686 HSP150 853281 HSP150 Saccharomyces cerevisiae Hsp150p NP_012376.3 120445 D 4932 CDS NP_012377.1 6322303 853282 complement(122261..122944) 1 NC_001142.7 Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family; Cis3p 122944 CIS3 853282 CIS3 Saccharomyces cerevisiae Cis3p NP_012377.1 122261 R 4932 CDS NP_012378.1 6322304 853283 complement(123832..126324) 1 NC_001142.7 Far1p; Cyclin-dependent kinase inhibitor that mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate 126324 FAR1 853283 FAR1 Saccharomyces cerevisiae Cyclin-dependent kinase inhibitor that mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate NP_012378.1 123832 R 4932 CDS NP_012379.1 6322305 853285 complement(126886..128949) 1 NC_001142.7 Ssy5p; Probable serine protease of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that regulate expression of amino acid permease genes 128949 SSY5 853285 SSY5 Saccharomyces cerevisiae Probable serine protease of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that regulate expression of amino acid permease genes NP_012379.1 126886 R 4932 CDS NP_012380.1 6322306 853286 complement(129282..130640) 1 NC_001142.7 Fructose-2,6-bisphosphatase, required for glucose metabolism; Fbp26p 130640 FBP26 853286 FBP26 Saccharomyces cerevisiae Fbp26p NP_012380.1 129282 R 4932 CDS NP_012381.1 6322307 853287 complement(131098..133932) 1 NC_001142.7 Vps35p; Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval 133932 VPS35 853287 VPS35 Saccharomyces cerevisiae Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval NP_012381.1 131098 R 4932 CDS NP_012382.2 37362665 853288 complement(134329..135930) 1 NC_001142.7 Inositol 1-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element; Ino1p 135930 INO1 853288 INO1 Saccharomyces cerevisiae Ino1p NP_012382.2 134329 R 4932 CDS NP_012384.1 6322310 853290 complement(136369..136770) 1 NC_001142.7 Sna3p; Integral membrane protein localized to vacuolar intralumenal vesicles, computational analysis of large-scale protein-protein interaction data suggests a possible role in either cell wall synthesis or protein-vacuolar targeting 136770 SNA3 853290 SNA3 Saccharomyces cerevisiae Integral membrane protein localized to vacuolar intralumenal vesicles, computational analysis of large-scale protein-protein interaction data suggests a possible role in either cell wall synthesis or protein-vacuolar targeting NP_012384.1 136369 R 4932 CDS NP_012386.1 6322312 853292 137376..139367 1 NC_001142.7 Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C; null mutant suppresses dst1delta sensitivity for 6-azauracil; Das1p 139367 DAS1 853292 DAS1 Saccharomyces cerevisiae Das1p NP_012386.1 137376 D 4932 CDS NP_012387.1 6322313 853293 140434..141135 1 NC_001142.7 Rpa34p; RNA polymerase I subunit A34.5 141135 RPA34 853293 RPA34 Saccharomyces cerevisiae RNA polymerase I subunit A34.5 NP_012387.1 140434 D 4932 CDS NP_012388.1 6322314 853294 complement(141416..142564) 1 NC_001142.7 Yjl147cp; Mitochondrial protein of unknown function; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene 142564 853294 YJL147C Saccharomyces cerevisiae Mitochondrial protein of unknown function; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene NP_012388.1 141416 R 4932 CDS NP_012389.1 6322315 853295 143289..144698 1 NC_001142.7 Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation; Ids2p 144698 IDS2 853295 IDS2 Saccharomyces cerevisiae Ids2p NP_012389.1 143289 D 4932 CDS NP_012390.1 6322316 853296 145157..146041 1 NC_001142.7 Sfh5p; Putative phosphatidylinositol transfer protein (PITP), exhibits phosphatidylinositol- but not phosphatidylcholine-transfer activity, localized to cytosol and microsomes, similar to Sec14p; may be PITP regulator rather than actual PITP 146041 SFH5 853296 SFH5 Saccharomyces cerevisiae Putative phosphatidylinositol transfer protein (PITP), exhibits phosphatidylinositol- but not phosphatidylcholine-transfer activity, localized to cytosol and microsomes, similar to Sec14p; may be PITP regulator rather than actual PITP NP_012390.1 145157 D 4932 CDS NP_012391.1 6322317 853297 146356..146670 1 NC_001142.7 Yjl144wp; Cytoplasmic hydrophilin of unknown function, possibly involved in the dessication response; expression induced by osmotic stress, starvation and during stationary phase; GFP-fusion protein is induced by the DNA-damaging agent MMS 146670 853297 YJL144W Saccharomyces cerevisiae Cytoplasmic hydrophilin of unknown function, possibly involved in the dessication response; expression induced by osmotic stress, starvation and during stationary phase; GFP-fusion protein is induced by the DNA-damaging agent MMS NP_012391.1 146356 D 4932 CDS NP_012392.1 6322318 853298 147098..147574 1 NC_001142.7 Tim17p; Essential constituent of the mitochondrial inner membrane presequence translocase; interacts with Pam18p to recruit the presequence translocase-associated motor (PAM complex) and also required for protein sorting during import 147574 TIM17 853298 TIM17 Saccharomyces cerevisiae Essential constituent of the mitochondrial inner membrane presequence translocase; interacts with Pam18p to recruit the presequence translocase-associated motor (PAM complex) and also required for protein sorting during import NP_012392.1 147098 D 4932 CDS NP_012394.1 6322320 853300 complement(147964..150387) 1 NC_001142.7 Yak1p; Serine-threonine protein kinase that is part of a glucose-sensing system involved in growth control in response to glucose availability; translocates from the cytoplasm to the nucleus and phosphorylates Pop2p in response to a glucose signal 150387 YAK1 853300 YAK1 Saccharomyces cerevisiae Serine-threonine protein kinase that is part of a glucose-sensing system involved in growth control in response to glucose availability; translocates from the cytoplasm to the nucleus and phosphorylates Pop2p in response to a glucose signal NP_012394.1 147964 R 4932 CDS NP_012395.1 6322321 853301 150958..151623 1 NC_001142.7 Rpb4p; RNA polymerase II subunit B32; forms two subunit dissociable complex with Rpb7p; dispensable under some environmental conditions; involved in export of mRNA to cytoplasm under stress conditions; involved in telomere maintenance 151623 RPB4 853301 RPB4 Saccharomyces cerevisiae RNA polymerase II subunit B32; forms two subunit dissociable complex with Rpb7p; dispensable under some environmental conditions; involved in export of mRNA to cytoplasm under stress conditions; involved in telomere maintenance NP_012395.1 150958 D 4932 CDS NP_012396.1 6322322 853302 complement(151710..152996) 1 NC_001142.7 Yur1p; Mannosyltransferase of the KTR1 family, involved in protein N-glycosylation; located in the Golgi apparatus 152996 YUR1 853302 YUR1 Saccharomyces cerevisiae Mannosyltransferase of the KTR1 family, involved in protein N-glycosylation; located in the Golgi apparatus NP_012396.1 151710 R 4932 CDS NP_012397.1 6322323 853303 complement(153501..154688) 1 NC_001142.7 Translation initiation factor eIF4A, identical to Tif1p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; Tif2p 154688 TIF2 853303 TIF2 Saccharomyces cerevisiae Tif2p NP_012397.1 153501 R 4932 CDS NP_012398.1 6322324 853304 complement(154982..156124) 1 NC_001142.7 Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; Glg2p 156124 GLG2 853304 GLG2 Saccharomyces cerevisiae Glg2p NP_012398.1 154982 R 4932 CDS NP_878101.1 33438819 1466464 156166..156249 1 NC_001142.7 Yjl136w-ap; Identified by SAGE 156249 1466464 YJL136W-A Saccharomyces cerevisiae Identified by SAGE NP_878101.1 156166 D 4932 CDS NP_012399.1 6322325 853305 complement(join(156547..156786,157247..157270)) 1 NC_001142.7 Rps21bp; Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Ap and has similarity to rat S21 ribosomal protein 157270 RPS21B 853305 RPS21B Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Ap and has similarity to rat S21 ribosomal protein NP_012399.1 156547 R 4932 CDS NP_012401.1 6322327 853307 158185..159414 1 NC_001142.7 Long-chain base-1-phosphate phosphatase with specificity for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; Lcb3p 159414 LCB3 853307 LCB3 Saccharomyces cerevisiae Lcb3p NP_012401.1 158185 D 4932 CDS NP_878102.1 33438820 1466465 complement(159620..159844) 1 NC_001142.7 Yjl133c-ap; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 159844 1466465 YJL133C-A Saccharomyces cerevisiae Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_878102.1 159620 R 4932 CDS NP_012402.1 6322328 853308 160616..161560 1 NC_001142.7 Mrs3p; Mitochondrial iron transporter of the mitochondrial carrier family (MCF), very similar to and functionally redundant with Mrs4p; functions under low-iron conditions; may transport other cations in addition to iron 161560 MRS3 853308 MRS3 Saccharomyces cerevisiae Mitochondrial iron transporter of the mitochondrial carrier family (MCF), very similar to and functionally redundant with Mrs4p; functions under low-iron conditions; may transport other cations in addition to iron NP_012402.1 160616 D 4932 CDS NP_012403.1 6322329 853309 161911..164163 1 NC_001142.7 Yjl132wp; Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene 164163 853309 YJL132W Saccharomyces cerevisiae Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene NP_012403.1 161911 D 4932 CDS NP_012404.1 6322330 853310 complement(164275..165345) 1 NC_001142.7 Putative protein of unknown function; the authentic non-tagged protein is detected in highly purified mitochondria; null mutant is viable, displays increased frequency of mitochondrial genome loss (petite formation); Aim23p 165345 AIM23 853310 AIM23 Saccharomyces cerevisiae Aim23p NP_012404.1 164275 R 4932 CDS NP_012405.1 6322331 853311 complement(165720..172364) 1 NC_001142.7 Ura2p; Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP 172364 URA2 853311 URA2 Saccharomyces cerevisiae Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP NP_012405.1 165720 R 4932 CDS NP_012406.1 6322332 853312 complement(173596..177303) 1 NC_001142.7 Trk1p; Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation 177303 TRK1 853312 TRK1 Saccharomyces cerevisiae Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation NP_012406.1 173596 R 4932 CDS NP_012407.1 6322333 853313 complement(178094..180100) 1 NC_001142.7 Pbs2p; MAP kinase kinase that plays a pivotal role in the osmosensing signal-transduction pathway, activated under severe osmotic stress 180100 PBS2 853313 PBS2 Saccharomyces cerevisiae MAP kinase kinase that plays a pivotal role in the osmosensing signal-transduction pathway, activated under severe osmotic stress NP_012407.1 178094 R 4932 CDS NP_878103.1 33438821 1466466 complement(181549..181707) 1 NC_001142.7 Yjl127c-bp; Putative protein of unknown function; identified based on homology to the filamentous fungus, Ashbya gossypii 181707 1466466 YJL127C-B Saccharomyces cerevisiae Putative protein of unknown function; identified based on homology to the filamentous fungus, Ashbya gossypii NP_878103.1 181549 R 4932 CDS NP_012408.1 6322334 853315 complement(182296..184218) 1 NC_001142.7 Spt10p; Putative histone acetylase, sequence-specific activator of histone genes, binds specifically and highly cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box 184218 SPT10 853315 SPT10 Saccharomyces cerevisiae Putative histone acetylase, sequence-specific activator of histone genes, binds specifically and highly cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box NP_012408.1 182296 R 4932 CDS NP_012409.1 6322335 853316 184499..185422 1 NC_001142.7 Nit2p; Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member 185422 NIT2 853316 NIT2 Saccharomyces cerevisiae Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member NP_012409.1 184499 D 4932 CDS NP_012410.1 6322336 853317 complement(185526..186677) 1 NC_001142.7 Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression; Gcd14p 186677 GCD14 853317 GCD14 Saccharomyces cerevisiae Gcd14p NP_012410.1 185526 R 4932 CDS NP_012411.1 6322337 853318 complement(187125..187643) 1 NC_001142.7 Lsm1p; Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs 187643 LSM1 853318 LSM1 Saccharomyces cerevisiae Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs NP_012411.1 187125 R 4932 CDS NP_012412.1 6322338 853319 complement(188003..189439) 1 NC_001142.7 Yjl123cp; Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); YJL123C is a non-essential gene 189439 853319 YJL123C Saccharomyces cerevisiae Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); YJL123C is a non-essential gene NP_012412.1 188003 R 4932 CDS NP_012413.1 6322339 853320 189715..190242 1 NC_001142.7 Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p; Alb1p 190242 ALB1 853320 ALB1 Saccharomyces cerevisiae Alb1p NP_012413.1 189715 D 4932 CDS NP_012414.1 6322341 853322 complement(190373..191089) 1 NC_001142.7 Rpe1p; D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress 191089 RPE1 853322 RPE1 Saccharomyces cerevisiae D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress NP_012414.1 190373 R 4932 CDS NP_012417.1 6322342 853323 191638..192297 1 NC_001142.7 Yjl118wp; Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; YJL18W is a non-essential gene; deletion enhances the toxicity of heterologously expressed human alpha-synuclein 192297 853323 YJL118W Saccharomyces cerevisiae Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; YJL18W is a non-essential gene; deletion enhances the toxicity of heterologously expressed human alpha-synuclein NP_012417.1 191638 D 4932 CDS NP_012418.1 6322344 853325 192530..193465 1 NC_001142.7 Pho86p; Endoplasmic reticulum (ER) resident protein required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles 193465 PHO86 853325 PHO86 Saccharomyces cerevisiae Endoplasmic reticulum (ER) resident protein required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles NP_012418.1 192530 D 4932 CDS NP_012419.1 6322345 853326 complement(193859..194872) 1 NC_001142.7 Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family; Nca3p 194872 NCA3 853326 NCA3 Saccharomyces cerevisiae Nca3p NP_012419.1 193859 R 4932 CDS NP_012420.1 6322346 853327 196285..197124 1 NC_001142.7 Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; Asf1p 197124 ASF1 853327 ASF1 Saccharomyces cerevisiae Asf1p NP_012420.1 196285 D 4932 CDS NP_012421.1 6322347 853330 join(197913..198998,199000..203325) 1 NC_001142.7 Yjl113wp; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 203325 853330 YJL113W Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_012421.1 197913 D 4932 CDS NP_012422.1 6322348 853329 197913..199157 1 NC_001142.7 Yjl114wp; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 199157 853329 YJL114W Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_012422.1 197913 D 4932 CDS NP_012423.1 6322349 853332 205301..207445 1 NC_001142.7 Peripheral protein of the cytosolic face of the mitochondrial outer membrane, required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats; Mdv1p 207445 MDV1 853332 MDV1 Saccharomyces cerevisiae Mdv1p NP_012423.1 205301 D 4932 CDS NP_012424.1 6322350 853333 207873..209525 1 NC_001142.7 Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; Cct7p 209525 CCT7 853333 CCT7 Saccharomyces cerevisiae Cct7p NP_012424.1 207873 D 4932 CDS NP_012425.1 6322351 853334 complement(209918..211573) 1 NC_001142.7 Gzf3p; GATA zinc finger protein and Dal80p homolog that negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p 211573 GZF3 853334 GZF3 Saccharomyces cerevisiae GATA zinc finger protein and Dal80p homolog that negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p NP_012425.1 209918 R 4932 CDS NP_012426.1 6322352 853335 complement(211996..217305) 1 NC_001142.7 Utp10p; Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA 217305 UTP10 853335 UTP10 Saccharomyces cerevisiae Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA NP_012426.1 211996 R 4932 CDS NP_012427.1 6322353 853336 complement(217701..218852) 1 NC_001142.7 Prm10p; Pheromone-regulated protein, predicted to have 5 transmembrane segments 218852 PRM10 853336 PRM10 Saccharomyces cerevisiae Pheromone-regulated protein, predicted to have 5 transmembrane segments NP_012427.1 217701 R 4932 CDS NP_012428.1 6322354 853337 complement(218849..220012) 1 NC_001142.7 Yjl107cp; Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi 220012 853337 YJL107C Saccharomyces cerevisiae Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi NP_012428.1 218849 R 4932 CDS NP_012429.1 6322355 853338 221386..223323 1 NC_001142.7 Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p; Ime2p 223323 IME2 853338 IME2 Saccharomyces cerevisiae Ime2p NP_012429.1 221386 D 4932 CDS NP_012430.1 6322356 853339 225051..226733 1 NC_001142.7 Set4p; Protein of unknown function, contains a SET domain 226733 SET4 853339 SET4 Saccharomyces cerevisiae Protein of unknown function, contains a SET domain NP_012430.1 225051 D 4932 CDS NP_012431.1 6322357 853340 227323..227772 1 NC_001142.7 Pam16p; Constituent of the mitochondrial import motor associated with the presequence translocase, along with Ssc1p, Tim44p, Mge1p, and Pam18p; forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains J-like domain 227772 PAM16 853340 PAM16 Saccharomyces cerevisiae Constituent of the mitochondrial import motor associated with the presequence translocase, along with Ssc1p, Tim44p, Mge1p, and Pam18p; forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains J-like domain NP_012431.1 227323 D 4932 CDS NP_012432.1 6322358 853341 complement(229021..230877) 1 NC_001142.7 Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis; Gsm1p 230877 GSM1 853341 GSM1 Saccharomyces cerevisiae Gsm1p NP_012432.1 229021 R 4932 CDS NP_012433.1 6322359 853342 231297..233756 1 NC_001142.7 Mitochondrial elongation factor involved in translational elongation; Mef2p 233756 MEF2 853342 MEF2 Saccharomyces cerevisiae Mef2p NP_012433.1 231297 D 4932 CDS NP_012434.1 6322360 853344 complement(234316..236352) 1 NC_001142.7 Gsh1p; Gamma glutamylcysteine synthetase catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury 236352 GSH1 853344 GSH1 Saccharomyces cerevisiae Gamma glutamylcysteine synthetase catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury NP_012434.1 234316 R 4932 CDS NP_012435.1 6322361 853345 237259..239082 1 NC_001142.7 Phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; Lsb6p 239082 LSB6 853345 LSB6 Saccharomyces cerevisiae Lsb6p NP_012435.1 237259 D 4932 CDS NP_012436.1 6322362 853346 239410..241650 1 NC_001142.7 Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; Chs6p 241650 CHS6 853346 CHS6 Saccharomyces cerevisiae Chs6p NP_012436.1 239410 D 4932 CDS NP_012437.1 6322363 853347 242078..245254 1 NC_001142.7 Sap185p; Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p 245254 SAP185 853347 SAP185 Saccharomyces cerevisiae Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p NP_012437.1 242078 D 4932 CDS NP_012438.1 6322364 853348 245587..246240 1 NC_001142.7 Protein of unknown function; homolog of mammalian PTPLA; involved in sphingolipid biosynthesis, protein trafficking; required for cell viability; Phs1p 246240 PHS1 853348 PHS1 Saccharomyces cerevisiae Phs1p NP_012438.1 245587 D 4932 CDS NP_012439.2 37362666 853349 246486..246971 1 NC_001142.7 Mrpl49p; Mitochondrial ribosomal protein of the large subunit 246971 MRPL49 853349 MRPL49 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit NP_012439.2 246486 D 4932 CDS NP_012440.1 6322366 853350 247250..251686 1 NC_001142.7 Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p; Bck1p 251686 BCK1 853350 BCK1 Saccharomyces cerevisiae Bck1p NP_012440.1 247250 D 4932 CDS NP_012441.1 6322367 853351 complement(251816..254437) 1 NC_001142.7 Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies; Kha1p 254437 KHA1 853351 KHA1 Saccharomyces cerevisiae Kha1p NP_012441.1 251816 R 4932 CDS NP_012442.1 6322368 853352 complement(254732..256807) 1 NC_001142.7 Tok1p; Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin 256807 TOK1 853352 TOK1 Saccharomyces cerevisiae Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin NP_012442.1 254732 R 4932 CDS NP_012443.1 6322369 853353 257418..260942 1 NC_001142.7 Srs2p; DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; affects genome stability by suppressing unscheduled homologous recombination 260942 SRS2 853353 SRS2 Saccharomyces cerevisiae DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; affects genome stability by suppressing unscheduled homologous recombination NP_012443.1 257418 D 4932 CDS NP_012444.2 37362667 853354 complement(261075..262547) 1 NC_001142.7 Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors; Gwt1p 262547 GWT1 853354 GWT1 Saccharomyces cerevisiae Gwt1p NP_012444.2 261075 R 4932 CDS NP_012445.1 6322371 853355 complement(262752..265046) 1 NC_001142.7 Subunit of DNA Polymerase II Epsilon complex; has BRCT domain, required on the prereplicative complex at replication origins for loading DNA polymerases to initiate DNA synthesis, also required for S/M checkpoint control; Dpb11p 265046 DPB11 853355 DPB11 Saccharomyces cerevisiae Dpb11p NP_012445.1 262752 R 4932 CDS NP_012446.1 6322372 853356 265921..268410 1 NC_001142.7 Sip4p; C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus 268410 SIP4 853356 SIP4 Saccharomyces cerevisiae C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus NP_012446.1 265921 D 4932 CDS NP_012447.1 6322373 853357 268794..269810 1 NC_001142.7 Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine; Arg3p 269810 ARG3 853357 ARG3 Saccharomyces cerevisiae Arg3p NP_012447.1 268794 D 4932 CDS NP_012448.1 6322374 853358 complement(269997..272480) 1 NC_001142.7 tRNA ligase, required for tRNA splicing; composed of three essential domains containing the phosphodiesterase, polynucleotide kinase, and ligase activities required for ligation; localized at the inner membrane of the nuclear envelope; Trl1p 272480 TRL1 853358 TRL1 Saccharomyces cerevisiae Trl1p NP_012448.1 269997 R 4932 CDS NP_012450.1 6322375 853359 272822..274693 1 NC_001142.7 Exo70p; Essential 70kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis 274693 EXO70 853359 EXO70 Saccharomyces cerevisiae Essential 70kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis NP_012450.1 272822 D 4932 CDS NP_012451.1 6322377 853361 complement(274857..277997) 1 NC_001142.7 Cytoplasmic protein of unknown function that interacts with the cyclin Pcl7p; phosphorylated in vitro by the cyclin-CDK complex, Pcl7p-Pho85p; identified as a potential Cdc28p substrate; mRNA is cell cycle regulated, peaking in M phase; Aly2p 277997 ALY2 853361 ALY2 Saccharomyces cerevisiae Aly2p NP_012451.1 274857 R 4932 CDS NP_012452.1 6322378 853362 278836..280650 1 NC_001142.7 Tax4p; Protein involved in regulation of phosphatidylinositol 4,5-bisphosphate concentrations; Irs4p and Tax4p bind and activate the phosphatase Inp51p 280650 TAX4 853362 TAX4 Saccharomyces cerevisiae Protein involved in regulation of phosphatidylinositol 4,5-bisphosphate concentrations; Irs4p and Tax4p bind and activate the phosphatase Inp51p NP_012452.1 278836 D 4932 CDS NP_012453.1 6322379 853363 281180..283375 1 NC_001142.7 Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Iml2p 283375 IML2 853363 IML2 Saccharomyces cerevisiae Iml2p NP_012453.1 281180 D 4932 CDS NP_012454.1 6322380 853364 complement(283797..285266) 1 NC_001142.7 Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; Arp4p 285266 ARP4 853364 ARP4 Saccharomyces cerevisiae Arp4p NP_012454.1 283797 R 4932 CDS NP_012455.1 6322381 853365 complement(285553..289221) 1 NC_001142.7 Scp160p; Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins 289221 SCP160 853365 SCP160 Saccharomyces cerevisiae Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins NP_012455.1 285553 R 4932 CDS NP_012456.1 6322382 853366 complement(289870..290769) 1 NC_001142.7 Pry1p; Protein of unknown function, has similarity to Pry2p and Pry3p and to the plant PR-1 class of pathogen related proteins 290769 PRY1 853366 PRY1 Saccharomyces cerevisiae Protein of unknown function, has similarity to Pry2p and Pry3p and to the plant PR-1 class of pathogen related proteins NP_012456.1 289870 R 4932 CDS NP_012457.1 6322383 853367 complement(291331..293976) 1 NC_001142.7 Pry3p; Protein of unknown function, has similarity to Pry1p and Pry2p and to the plant PR-1 class of pathogen related proteins 293976 PRY3 853367 PRY3 Saccharomyces cerevisiae Protein of unknown function, has similarity to Pry1p and Pry2p and to the plant PR-1 class of pathogen related proteins NP_012457.1 291331 R 4932 CDS NP_878104.1 33438822 1466467 294042..294140 1 NC_001142.7 Yjl077w-bp; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 294140 1466467 YJL077W-B Saccharomyces cerevisiae Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching NP_878104.1 294042 D 4932 CDS NP_012458.1 6322384 853368 complement(294661..295056) 1 NC_001142.7 Ics3p 295056 ICS3 853368 ICS3 Saccharomyces cerevisiae Ics3p NP_012458.1 294661 R 4932 CDS NP_012459.1 6322385 853369 295240..298809 1 NC_001142.7 Net1p; Core subunit of the RENT complex, which is a complex involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure 298809 NET1 853369 NET1 Saccharomyces cerevisiae Core subunit of the RENT complex, which is a complex involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure NP_012459.1 295240 D 4932 CDS NP_012461.1 6322387 853371 complement(299152..302844) 1 NC_001142.7 Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member; Smc3p 302844 SMC3 853371 SMC3 Saccharomyces cerevisiae Smc3p NP_012461.1 299152 R 4932 CDS NP_012462.1 6322388 853372 303176..305113 1 NC_001142.7 Jem1p; DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2 305113 JEM1 853372 JEM1 Saccharomyces cerevisiae DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2 NP_012462.1 303176 D 4932 CDS NP_012463.1 6322389 853373 complement(305216..305857) 1 NC_001142.7 Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery; Psf2p 305857 PSF2 853373 PSF2 Saccharomyces cerevisiae Psf2p NP_012463.1 305216 R 4932 CDS NP_012464.1 6322390 853374 306127..307851 1 NC_001142.7 Arg2p; Acetylglutamate synthase (glutamate N-acetyltransferase), mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p 307851 ARG2 853374 ARG2 Saccharomyces cerevisiae Acetylglutamate synthase (glutamate N-acetyltransferase), mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p NP_012464.1 306127 D 4932 CDS NP_012465.1 6322391 853375 complement(307966..310632) 1 NC_001142.7 Yjl070cp; Putative protein of unknown function with similarity to AMP deaminases; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YJL070C is a non-essential gene 310632 853375 YJL070C Saccharomyces cerevisiae Putative protein of unknown function with similarity to AMP deaminases; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YJL070C is a non-essential gene NP_012465.1 307966 R 4932 CDS NP_012466.1 6322392 853376 complement(310917..312701) 1 NC_001142.7 Utp18p; Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data 312701 UTP18 853376 UTP18 Saccharomyces cerevisiae Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data NP_012466.1 310917 R 4932 CDS NP_012467.1 6322393 853377 complement(313011..313910) 1 NC_001142.7 Yjl068cp; Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D 313910 853377 YJL068C Saccharomyces cerevisiae Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D NP_012467.1 313011 R 4932 CDS NP_012469.1 6322395 853379 complement(314109..314867) 1 NC_001142.7 Mpm1p; Mitochondrial membrane protein of unknown function, contains no hydrophobic stretches 314867 MPM1 853379 MPM1 Saccharomyces cerevisiae Mitochondrial membrane protein of unknown function, contains no hydrophobic stretches NP_012469.1 314109 R 4932 CDS NP_012470.1 6322397 853381 complement(315049..315552) 1 NC_001142.7 Subunit of ISW2/yCHRAC chromatin accessibility complex along with Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing; Dls1p 315552 DLS1 853381 DLS1 Saccharomyces cerevisiae Dls1p NP_012470.1 315049 R 4932 CDS NP_012472.1 6322398 853382 complement(315754..316470) 1 NC_001142.7 Mrpl8p; Mitochondrial ribosomal protein of the large subunit 316470 MRPL8 853382 MRPL8 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit NP_012472.1 315754 R 4932 CDS NP_076894.1 13129172 853383 316718..316975 1 NC_001142.7 Yjl062w-ap; Putative protein of unknown function, identified based on comparison to related yeast species; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 316975 853383 YJL062W-A Saccharomyces cerevisiae Putative protein of unknown function, identified based on comparison to related yeast species; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_076894.1 316718 D 4932 CDS NP_012473.1 6322399 853384 317279..319771 1 NC_001142.7 Las21p; Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity 319771 LAS21 853384 LAS21 Saccharomyces cerevisiae Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity NP_012473.1 317279 D 4932 CDS NP_012474.1 6322400 853385 320011..322152 1 NC_001142.7 Nup82p; Nucleoporin, subunit of the nuclear pore complex (NPC); forms a subcomplex with Nup159p and Nsp1p, interacts with Nup116p and is required for proper localization of Nup116p in the NPC 322152 NUP82 853385 NUP82 Saccharomyces cerevisiae Nucleoporin, subunit of the nuclear pore complex (NPC); forms a subcomplex with Nup159p and Nsp1p, interacts with Nup116p and is required for proper localization of Nup116p in the NPC NP_012474.1 320011 D 4932 CDS NP_012475.1 6322401 853386 323381..324715 1 NC_001142.7 Bna3p; Arylformamidase, involved in biosynthesis of nicotinic acid from tryptophan via kynurenine pathway; potential Cdc28p substrate 324715 BNA3 853386 BNA3 Saccharomyces cerevisiae Arylformamidase, involved in biosynthesis of nicotinic acid from tryptophan via kynurenine pathway; potential Cdc28p substrate NP_012475.1 323381 D 4932 CDS NP_012476.1 6322402 853387 324959..326185 1 NC_001142.7 Yhc3p; Vacuolar membrane protein involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; homolog of human CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis) 326185 YHC3 853387 YHC3 Saccharomyces cerevisiae Vacuolar membrane protein involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; homolog of human CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis) NP_012476.1 324959 D 4932 CDS NP_012477.1 6322403 853388 complement(326237..327868) 1 NC_001142.7 Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p-Slm1p-Slm2p), a membrane-associated complex that regulates cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; Bit61p 327868 BIT61 853388 BIT61 Saccharomyces cerevisiae Bit61p NP_012477.1 326237 R 4932 CDS NP_012478.1 6322404 853389 complement(328113..330116) 1 NC_001142.7 Putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p; Iks1p 330116 IKS1 853389 IKS1 Saccharomyces cerevisiae Iks1p NP_012478.1 328113 R 4932 CDS NP_012479.1 6322405 853390 complement(330426..333068) 1 NC_001142.7 Zinc-regulated transcription factor, binds to zinc-responsive promoter elements to induce transcription of certain genes in the presence of zinc; regulates its own transcription; contains seven zinc-finger domains; Zap1p 333068 ZAP1 853390 ZAP1 Saccharomyces cerevisiae Zap1p NP_012479.1 330426 R 4932 CDS NP_012480.1 6322406 853391 333352..334089 1 NC_001142.7 Yjl055wp; Putative protein of unknown function, proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA; overexpression confers resistance to 5-FOA and 5-FU 334089 853391 YJL055W Saccharomyces cerevisiae Putative protein of unknown function, proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA; overexpression confers resistance to 5-FOA and 5-FU NP_012480.1 333352 D 4932 CDS NP_012481.1 6322407 853392 334260..335696 1 NC_001142.7 Tim54p; Component of the mitochondrial Tim54p-Tim22p complex involved in insertion of polytopic proteins into the inner membrane 335696 TIM54 853392 TIM54 Saccharomyces cerevisiae Component of the mitochondrial Tim54p-Tim22p complex involved in insertion of polytopic proteins into the inner membrane NP_012481.1 334260 D 4932 CDS NP_012482.1 6322408 853393 335893..337032 1 NC_001142.7 Vacuolar protein sorting protein that forms part of the multimeric membrane-associated retromer complex along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; Pep8p 337032 PEP8 853393 PEP8 Saccharomyces cerevisiae Pep8p NP_012482.1 335893 D 4932 CDS NP_076895.1 13129173 853394 complement(337879..337998) 1 NC_001142.7 Yjl052c-ap; Putative protein of unknown function, identified based on comparison to related yeast species 337998 853394 YJL052C-A Saccharomyces cerevisiae Putative protein of unknown function, identified based on comparison to related yeast species NP_076895.1 337879 R 4932 CDS NP_012483.1 6322409 853395 338266..339264 1 NC_001142.7 Tdh1p; Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall 339264 TDH1 853395 TDH1 Saccharomyces cerevisiae Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall NP_012483.1 338266 D 4932 CDS NP_012484.1 6322410 853396 339782..342250 1 NC_001142.7 Irc8p; Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52 foci 342250 IRC8 853396 IRC8 Saccharomyces cerevisiae Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52 foci NP_012484.1 339782 D 4932 CDS NP_012485.1 6322411 853397 342517..345738 1 NC_001142.7 Mtr4p; Dead-box family ATP dependent helicase required for mRNA export from the nucleus; co-factor of the exosome complex, required for 3' end formation of 5.8S rRNA 345738 MTR4 853397 MTR4 Saccharomyces cerevisiae Dead-box family ATP dependent helicase required for mRNA export from the nucleus; co-factor of the exosome complex, required for 3' end formation of 5.8S rRNA NP_012485.1 342517 D 4932 CDS NP_012486.1 6322412 853398 345968..347320 1 NC_001142.7 Yjl049wp; Putative protein of unknown function; YJL049W is a non-essential gene 347320 853398 YJL049W Saccharomyces cerevisiae Putative protein of unknown function; YJL049W is a non-essential gene NP_012486.1 345968 D 4932 CDS NP_012487.1 6322413 853399 complement(347442..348632) 1 NC_001142.7 Ubx6p; UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline 348632 UBX6 853399 UBX6 Saccharomyces cerevisiae UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline NP_012487.1 347442 R 4932 CDS NP_878105.1 33438823 1466468 complement(349039..349173) 1 NC_001142.7 Yjl047c-ap; Putative protein of unknown function 349173 1466468 YJL047C-A Saccharomyces cerevisiae Putative protein of unknown function NP_878105.1 349039 R 4932 CDS NP_012488.1 6322414 853400 complement(349575..352103) 1 NC_001142.7 Rtt101p; Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex; deletion phenotype suggests a role in anaphase progression; interacts with Mms22p and implicated in Mms22-dependent DNA repair; modified by the ubiquitin-like protein, Rub1p 352103 RTT101 853400 RTT101 Saccharomyces cerevisiae Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex; deletion phenotype suggests a role in anaphase progression; interacts with Mms22p and implicated in Mms22-dependent DNA repair; modified by the ubiquitin-like protein, Rub1p NP_012488.1 349575 R 4932 CDS NP_012489.2 83578101 853401 352381..353610 1 NC_001142.7 Putative lipoate-protein ligase A family member; null mutant displays respiratory growth defect, decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media; Aim22p 353610 AIM22 853401 AIM22 Saccharomyces cerevisiae Aim22p NP_012489.2 352381 D 4932 CDS NP_012490.1 6322416 853405 356019..357923 1 NC_001142.7 Yjl045wp; Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner 357923 853405 YJL045W Saccharomyces cerevisiae Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner NP_012490.1 356019 D 4932 CDS NP_012491.1 6322417 853406 complement(358295..359671) 1 NC_001142.7 Gyp6p; GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated protein transport 359671 GYP6 853406 GYP6 Saccharomyces cerevisiae GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated protein transport NP_012491.1 358295 R 4932 CDS NP_012492.1 6322418 853407 360125..360898 1 NC_001142.7 Yjl043wp; Putative protein of unknown function; YJL043W is a non-essential gene 360898 853407 YJL043W Saccharomyces cerevisiae Putative protein of unknown function; YJL043W is a non-essential gene NP_012492.1 360125 D 4932 CDS NP_012493.1 6322419 853408 361244..365440 1 NC_001142.7 Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins; Mhp1p 365440 MHP1 853408 MHP1 Saccharomyces cerevisiae Mhp1p NP_012493.1 361244 D 4932 CDS NP_012494.1 6322420 853409 join(365779,365898..368368) 1 NC_001142.7 Nsp1p; Essential component of the nuclear pore complex, which mediates nuclear import and export 368368 NSP1 853409 NSP1 Saccharomyces cerevisiae Essential component of the nuclear pore complex, which mediates nuclear import and export NP_012494.1 365779 D 4932 CDS NP_012495.1 6322421 853410 complement(368743..373794) 1 NC_001142.7 Nup192p; Essential structural subunit of the nuclear pore complex (NPC), localizes to the nuclear periphery of nuclear pores, homologous to human p205 373794 NUP192 853410 NUP192 Saccharomyces cerevisiae Essential structural subunit of the nuclear pore complex (NPC), localizes to the nuclear periphery of nuclear pores, homologous to human p205 NP_012495.1 368743 R 4932 CDS NP_012496.1 6322422 853413 complement(375110..375769) 1 NC_001142.7 Yjl038cp; Putative protein of unknown function; expression induced during sporulation and repressed during vegetative growth by Sum1p and Hst1p; similar to adjacent open reading frame, YJL037W 375769 853413 YJL038C Saccharomyces cerevisiae Putative protein of unknown function; expression induced during sporulation and repressed during vegetative growth by Sum1p and Hst1p; similar to adjacent open reading frame, YJL037W NP_012496.1 375110 R 4932 CDS NP_012497.1 6322423 853414 376657..377331 1 NC_001142.7 Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52 foci; Irc18p 377331 IRC18 853414 IRC18 Saccharomyces cerevisiae Irc18p NP_012497.1 376657 D 4932 CDS NP_012498.1 6322424 853416 378820..380091 1 NC_001142.7 Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX domain; forms complex with Snx41p and Atg20p; Snx4p 380091 SNX4 853416 SNX4 Saccharomyces cerevisiae Snx4p NP_012498.1 378820 D 4932 CDS NP_012499.1 6322425 853417 complement(380244..380996) 1 NC_001142.7 Tad2p; Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs 380996 TAD2 853417 TAD2 Saccharomyces cerevisiae Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs NP_012499.1 380244 R 4932 CDS NP_012500.1 6322426 853418 381322..383370 1 NC_001142.7 Kar2p; ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p 383370 KAR2 853418 KAR2 Saccharomyces cerevisiae ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p NP_012500.1 381322 D 4932 CDS NP_012501.1 6322427 853419 383832..386144 1 NC_001142.7 Putative nucleolar DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis; Hca4p 386144 HCA4 853419 HCA4 Saccharomyces cerevisiae Hca4p NP_012501.1 383832 D 4932 CDS NP_012503.2 41629687 853421 complement(join(386363..387343,387431..387433)) 1 NC_001142.7 Bet4p; Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p 387433 BET4 853421 BET4 Saccharomyces cerevisiae Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p NP_012503.2 386363 R 4932 CDS NP_012504.1 6322430 853422 387652..388242 1 NC_001142.7 Mad2p; Component of the spindle-assembly checkpoint complex, which delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p 388242 MAD2 853422 MAD2 Saccharomyces cerevisiae Component of the spindle-assembly checkpoint complex, which delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p NP_012504.1 387652 D 4932 CDS NP_012505.1 6322431 853423 complement(388380..390848) 1 NC_001142.7 Vps53p; Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting 390848 VPS53 853423 VPS53 Saccharomyces cerevisiae Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting NP_012505.1 388380 R 4932 CDS NP_012506.1 6322432 853425 391306..391641 1 NC_001142.7 Yjl028wp; Protein of unknown function; may interact with ribosomes, based on co-purification experiments 391641 853425 YJL028W Saccharomyces cerevisiae Protein of unknown function; may interact with ribosomes, based on co-purification experiments NP_012506.1 391306 D 4932 CDS NP_012507.1 6322433 853426 complement(391828..392244) 1 NC_001142.7 Yjl027cp; Putative protein of unknown function 392244 853426 YJL027C Saccharomyces cerevisiae Putative protein of unknown function NP_012507.1 391828 R 4932 CDS NP_012508.1 6322434 853427 392399..393598 1 NC_001142.7 Rnr2p; Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits 393598 RNR2 853427 RNR2 Saccharomyces cerevisiae Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits NP_012508.1 392399 D 4932 CDS NP_012509.1 6322435 853428 393962..395506 1 NC_001142.7 Rrn7p; Protein involved in the transcription of 35S rRNA genes by RNA polymerase I; component of the core factor (CF) complex also composed of Rrn11p, Rrn6p and TATA-binding protein 395506 RRN7 853428 RRN7 Saccharomyces cerevisiae Protein involved in the transcription of 35S rRNA genes by RNA polymerase I; component of the core factor (CF) complex also composed of Rrn11p, Rrn6p and TATA-binding protein NP_012509.1 393962 D 4932 CDS NP_012510.1 6322436 853429 complement(join(395926..396488,396566..396587)) 1 NC_001142.7 Small subunit of the clathrin-associated adaptor complex AP-3, which is involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; Aps3p 396587 APS3 853429 APS3 Saccharomyces cerevisiae Aps3p NP_012510.1 395926 R 4932 CDS NP_012511.1 6322438 853432 complement(397350..398393) 1 NC_001142.7 Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Pet130p 398393 PET130 853432 PET130 Saccharomyces cerevisiae Pet130p NP_012511.1 397350 R 4932 CDS NP_012514.2 14627173 853433 complement(398932..402405) 1 NC_001142.7 Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches; Bbc1p 402405 BBC1 853433 BBC1 Saccharomyces cerevisiae Bbc1p NP_012514.2 398932 R 4932 CDS NP_012515.2 27808709 853434 402892..404940 1 NC_001142.7 Mps3p; Essential integral membrane protein required for spindle pole body duplication and for nuclear fusion, localizes to the spindle pole body half bridge, interacts with DnaJ-like chaperone Jem1p and with centrin homolog Cdc31p 404940 MPS3 853434 MPS3 Saccharomyces cerevisiae Essential integral membrane protein required for spindle pole body duplication and for nuclear fusion, localizes to the spindle pole body half bridge, interacts with DnaJ-like chaperone Jem1p and with centrin homolog Cdc31p NP_012515.2 402892 D 4932 CDS NP_012518.2 37362668 853436 405583..407268 1 NC_001142.7 Yjl016wp; Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; conserved in closely related Saccharomyces species 407268 853436 YJL016W Saccharomyces cerevisiae Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; conserved in closely related Saccharomyces species NP_012518.2 405583 D 4932 CDS NP_012520.1 6322446 853438 407552..409156 1 NC_001142.7 Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; Cct3p 409156 CCT3 853438 CCT3 Saccharomyces cerevisiae Cct3p NP_012520.1 407552 D 4932 CDS NP_012521.1 6322447 853439 complement(409487..411034) 1 NC_001142.7 Subunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover; Mad3p 411034 MAD3 853439 MAD3 Saccharomyces cerevisiae Mad3p NP_012521.1 409487 R 4932 CDS NP_012522.2 42742256 853441 complement(411228..413393) 1 NC_001142.7 Vtc4p; Vacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in non-autophagic vacuolar fusion 413393 VTC4 853441 VTC4 Saccharomyces cerevisiae Vacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in non-autophagic vacuolar fusion NP_012522.2 411228 R 4932 CDS NP_012523.1 6322449 853442 complement(414279..414764) 1 NC_001142.7 Rpc17p; RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex 414764 RPC17 853442 RPC17 Saccharomyces cerevisiae RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex NP_012523.1 414279 R 4932 CDS NP_012524.1 6322450 853445 complement(417556..419556) 1 NC_001142.7 Nop9p; Essential component of pre-40S ribosomes that is required for early cleavages of 35S pre-rRNA and hence formation of 18S rRNA; binds RNA in vitro and contains multiple pumilio-like repeats 419556 NOP9 853445 NOP9 Saccharomyces cerevisiae Essential component of pre-40S ribosomes that is required for early cleavages of 35S pre-rRNA and hence formation of 18S rRNA; binds RNA in vitro and contains multiple pumilio-like repeats NP_012524.1 417556 R 4932 CDS NP_012526.1 6322452 853447 complement(419951..421657) 1 NC_001142.7 Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; Cct8p 421657 CCT8 853447 CCT8 Saccharomyces cerevisiae Cct8p NP_012526.1 419951 R 4932 CDS NP_012528.1 6322454 853450 complement(423132..424103) 1 NC_001142.7 Ctk2p; Beta subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing; has similarity to cyclins 424103 CTK2 853450 CTK2 Saccharomyces cerevisiae Beta subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing; has similarity to cyclins NP_012528.1 423132 R 4932 CDS NP_012529.1 6322455 853452 425151..431231 1 NC_001142.7 Cyr1p; Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation 431231 CYR1 853452 CYR1 Saccharomyces cerevisiae Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation NP_012529.1 425151 D 4932 CDS NP_012530.1 6322456 853453 complement(431583..432194) 1 NC_001142.7 Sys1p; Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation 432194 SYS1 853453 SYS1 Saccharomyces cerevisiae Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation NP_012530.1 431583 R 4932 CDS NP_012531.1 6322457 853454 432638..432994 1 NC_001142.7 Mitochondrial inner membrane protein, required for assembly of cytochrome c oxidase; Cox16p 432994 COX16 853454 COX16 Saccharomyces cerevisiae Cox16p NP_012531.1 432638 D 4932 CDS NP_012532.1 6322458 853455 complement(433215..434645) 1 NC_001142.7 Ost1p; Alpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins 434645 OST1 853455 OST1 Saccharomyces cerevisiae Alpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins NP_012532.1 433215 R 4932 CDS NP_012533.1 6322459 853456 join(435157..435221,435338..435920) 1 NC_001142.7 Pre3p; 20S proteasome beta-type subunit, responsible for cleavage after acidic residues in peptides 435920 PRE3 853456 PRE3 Saccharomyces cerevisiae 20S proteasome beta-type subunit, responsible for cleavage after acidic residues in peptides NP_012533.1 435157 D 4932 CDS NP_012534.1 6322460 853457 436796..438604 1 NC_001142.7 Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; Avt1p 438604 AVT1 853457 AVT1 Saccharomyces cerevisiae Avt1p NP_012534.1 436796 D 4932 CDS NP_012535.1 6322461 853458 438858..440639 1 NC_001142.7 Mpp10p; Component of the SSU processome, which is required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p 440639 MPP10 853458 MPP10 Saccharomyces cerevisiae Component of the SSU processome, which is required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p NP_012535.1 438858 D 4932 CDS NP_012536.2 99030925 853459 complement(440987..442546) 1 NC_001142.7 Yjr003cp; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 442546 853459 YJR003C Saccharomyces cerevisiae Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_012536.2 440987 R 4932 CDS NP_012537.1 6322463 853460 complement(442902..444854) 1 NC_001142.7 Sag1p; Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor 444854 SAG1 853460 SAG1 Saccharomyces cerevisiae Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor NP_012537.1 442902 R 4932 CDS NP_012538.1 6322464 853461 445916..448018 1 NC_001142.7 Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex; Apl1p 448018 APL1 853461 APL1 Saccharomyces cerevisiae Apl1p NP_012538.1 445916 D 4932 CDS NP_878106.1 33438824 1466469 complement(448470..448751) 1 NC_001142.7 Yjr005c-ap; Putative protein of unknown function, originally identified as a syntenic homolog of an Ashbya gossypii gene 448751 1466469 YJR005C-A Saccharomyces cerevisiae Putative protein of unknown function, originally identified as a syntenic homolog of an Ashbya gossypii gene NP_878106.1 448470 R 4932 CDS NP_012539.1 6322465 853462 449195..450658 1 NC_001142.7 Pol31p; DNA polymerase III (delta) subunit, essential for cell viability; involved in DNA replication and DNA repair 450658 POL31 853462 POL31 Saccharomyces cerevisiae DNA polymerase III (delta) subunit, essential for cell viability; involved in DNA replication and DNA repair NP_012539.1 449195 D 4932 CDS NP_012540.1 6322466 853463 451013..451927 1 NC_001142.7 Sui2p; Alpha subunit of the translation initiation factor eIF2, involved in the identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP 451927 SUI2 853463 SUI2 Saccharomyces cerevisiae Alpha subunit of the translation initiation factor eIF2, involved in the identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP NP_012540.1 451013 D 4932 CDS NP_012541.1 6322467 853464 452423..453439 1 NC_001142.7 Yjr008wp; Putative protein of unknown function; expression repressed by inosine and choline in an Opi1p-dependent manner; expression induced by mild heat-stress on a non-fermentable carbon source. 453439 853464 YJR008W Saccharomyces cerevisiae Putative protein of unknown function; expression repressed by inosine and choline in an Opi1p-dependent manner; expression induced by mild heat-stress on a non-fermentable carbon source. NP_012541.1 452423 D 4932 CDS NP_012542.1 6322468 853465 complement(453676..454674) 1 NC_001142.7 Tdh2p; Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall 454674 TDH2 853465 TDH2 Saccharomyces cerevisiae Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall NP_012542.1 453676 R 4932 CDS NP_012543.1 6322469 853466 456232..457767 1 NC_001142.7 Met3p; ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism 457767 MET3 853466 MET3 Saccharomyces cerevisiae ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism NP_012543.1 456232 D 4932 CDS NP_012544.1 6322470 853467 complement(458070..458354) 1 NC_001142.7 Subunit of the signal peptidase complex (SPC), which cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER), homolog of the SPC12 subunit of mammalian signal peptidase complex; Spc1p 458354 SPC1 853467 SPC1 Saccharomyces cerevisiae Spc1p NP_012544.1 458070 R 4932 CDS NP_012545.1 6322471 853468 complement(458634..459419) 1 NC_001142.7 Yjr011cp; Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS 459419 853468 YJR011C Saccharomyces cerevisiae Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS NP_012545.1 458634 R 4932 CDS NP_012546.1 6322472 853469 complement(459788..460411) 1 NC_001142.7 Yjr012cp; Putative protein of unknown function; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; partially overlaps neighboring ORF, GPI14/YJR013W 460411 853469 YJR012C Saccharomyces cerevisiae Putative protein of unknown function; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; partially overlaps neighboring ORF, GPI14/YJR013W NP_012546.1 459788 R 4932 CDS NP_012547.2 42742257 853470 460375..461586 1 NC_001142.7 Gpi14p; Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M 461586 GPI14 853470 GPI14 Saccharomyces cerevisiae Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M NP_012547.2 460375 D 4932 CDS NP_012548.1 6322474 853471 461822..462418 1 NC_001142.7 Tma22p; Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1 462418 TMA22 853471 TMA22 Saccharomyces cerevisiae Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1 NP_012548.1 461822 D 4932 CDS NP_012549.1 6322475 853472 462714..464246 1 NC_001142.7 Yjr015wp; Putative protein of unknown function; localizes to the endoplasmic reticulum and cytoplasm; predicted to encode a membrane transporter based on phylogenetic analysis; YJR015W is a non-essential gene 464246 853472 YJR015W Saccharomyces cerevisiae Putative protein of unknown function; localizes to the endoplasmic reticulum and cytoplasm; predicted to encode a membrane transporter based on phylogenetic analysis; YJR015W is a non-essential gene NP_012549.1 462714 D 4932 CDS NP_012550.1 6322476 853473 complement(464444..466201) 1 NC_001142.7 Ilv3p; Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids 466201 ILV3 853473 ILV3 Saccharomyces cerevisiae Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids NP_012550.1 464444 R 4932 CDS NP_012551.2 37362669 853475 complement(466514..467026) 1 NC_001142.7 Peptidylprolyl-cis/trans-isomerase (PPIase) specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNA polymerase II large subunit (Rpo21p) C-terminal domain; Ess1p 467026 ESS1 853475 ESS1 Saccharomyces cerevisiae Ess1p NP_012551.2 466514 R 4932 CDS NP_012553.1 6322480 853477 complement(467225..468274) 1 NC_001142.7 Tes1p; Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids 468274 TES1 853477 TES1 Saccharomyces cerevisiae Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids NP_012553.1 467225 R 4932 CDS NP_012555.1 6322481 853478 complement(join(468548..469176,469257..469572)) 1 NC_001142.7 Rec107p; Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formation 469572 REC107 853478 REC107 Saccharomyces cerevisiae Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formation NP_012555.1 468548 R 4932 CDS NP_012556.2 37362670 853479 469777..470106 1 NC_001142.7 Lsm8p; Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA 470106 LSM8 853479 LSM8 Saccharomyces cerevisiae Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA NP_012556.2 469777 D 4932 CDS NP_012558.1 6322484 853481 complement(470223..470957) 1 NC_001142.7 Putative methylthio-ribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant; Mde1p 470957 MDE1 853481 MDE1 Saccharomyces cerevisiae Mde1p NP_012558.1 470223 R 4932 CDS NP_012559.1 6322485 853482 complement(471131..471664) 1 NC_001142.7 Bna1p; 3-hydroxyanthranilic acid dioxygenase, required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway 471664 BNA1 853482 BNA1 Saccharomyces cerevisiae 3-hydroxyanthranilic acid dioxygenase, required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway NP_012559.1 471131 R 4932 CDS NP_012560.1 6322487 853484 join(472753..474054,474056..478021) 1 NC_001142.7 Yjr027wp; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 478021 853484 YJR027W Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_012560.1 472753 D 4932 CDS NP_012561.1 6322486 853483 472753..474075 1 NC_001142.7 Yjr026wp; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 474075 853483 YJR026W Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_012561.1 472753 D 4932 CDS NP_012562.1 6322489 853486 join(478337..479637,479639..483605) 1 NC_001142.7 Yjr029wp; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 483605 853486 YJR029W Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_012562.1 478337 D 4932 CDS NP_012563.1 6322488 853485 478337..479659 1 NC_001142.7 Yjr028wp; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 479659 853485 YJR028W Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_012563.1 478337 D 4932 CDS NP_012564.1 6322490 853487 complement(483952..486189) 1 NC_001142.7 Yjr030cp; Putative protein of unknown function; expression repressed in carbon limited vs carbon replete chemostat cultures; YJR030C is a non-essential gene 486189 853487 YJR030C Saccharomyces cerevisiae Putative protein of unknown function; expression repressed in carbon limited vs carbon replete chemostat cultures; YJR030C is a non-essential gene NP_012564.1 483952 R 4932 CDS NP_012565.1 6322491 853488 complement(486579..490805) 1 NC_001142.7 Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs), involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; similar to but not functionally redundant with Gea2p; Gea1p 490805 GEA1 853488 GEA1 Saccharomyces cerevisiae Gea1p NP_012565.1 486579 R 4932 CDS NP_012566.1 6322492 853489 491074..492255 1 NC_001142.7 Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; Cpr7p 492255 CPR7 853489 CPR7 Saccharomyces cerevisiae Cpr7p NP_012566.1 491074 D 4932 CDS NP_012567.1 6322493 853490 complement(492371..496444) 1 NC_001142.7 Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate; Rav1p 496444 RAV1 853490 RAV1 Saccharomyces cerevisiae Rav1p NP_012567.1 492371 R 4932 CDS NP_012568.1 6322494 853491 496676..497002 1 NC_001142.7 Protein required for assembly of cytochrome c oxidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Pet191p 497002 PET191 853491 PET191 Saccharomyces cerevisiae Pet191p NP_012568.1 496676 D 4932 CDS NP_012569.1 6322495 853492 497348..500605 1 NC_001142.7 Rad26p; Protein involved in transcription-coupled repair nucleotide excision repair of UV-induced DNA lesions; homolog of human CSB protein 500605 RAD26 853492 RAD26 Saccharomyces cerevisiae Protein involved in transcription-coupled repair nucleotide excision repair of UV-induced DNA lesions; homolog of human CSB protein NP_012569.1 497348 D 4932 CDS NP_012570.1 6322497 853494 complement(500706..503384) 1 NC_001142.7 Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability; Hul4p 503384 HUL4 853494 HUL4 Saccharomyces cerevisiae Hul4p NP_012570.1 500706 R 4932 CDS NP_012573.1 6322498 853495 503929..507294 1 NC_001142.7 Yjr039wp; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 507294 853495 YJR039W Saccharomyces cerevisiae Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_012573.1 503929 D 4932 CDS NP_012574.1 6322500 853497 507739..510078 1 NC_001142.7 Gef1p; Chloride channel localized to late- or post-Golgi vesicles, involved in iron metabolism; highly homologous to voltage-gated chloride channels in vertebrates 510078 GEF1 853497 GEF1 Saccharomyces cerevisiae Chloride channel localized to late- or post-Golgi vesicles, involved in iron metabolism; highly homologous to voltage-gated chloride channels in vertebrates NP_012574.1 507739 D 4932 CDS NP_012575.1 6322501 853498 complement(510232..513756) 1 NC_001142.7 Urb2p; Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis 513756 URB2 853498 URB2 Saccharomyces cerevisiae Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis NP_012575.1 510232 R 4932 CDS NP_012576.1 6322502 853499 514048..516282 1 NC_001142.7 Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), required for assembly of the subcomplex and also for formation of the nucleocytoplasmic Gsp1p concentration gradient that plays a role in nuclear trafficking; Nup85p 516282 NUP85 853499 NUP85 Saccharomyces cerevisiae Nup85p NP_012576.1 514048 D 4932 CDS NP_012577.1 6322503 853500 complement(516454..517506) 1 NC_001142.7 Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p; Pol32p 517506 POL32 853500 POL32 Saccharomyces cerevisiae Pol32p NP_012577.1 516454 R 4932 CDS NP_012578.1 6322504 853502 complement(518756..519178) 1 NC_001142.7 Vps55p; Late endosomal protein involved in late endosome to vacuole trafficking; functional homolog of human obesity receptor gene-related protein (OB-RGRP) 519178 VPS55 853502 VPS55 Saccharomyces cerevisiae Late endosomal protein involved in late endosome to vacuole trafficking; functional homolog of human obesity receptor gene-related protein (OB-RGRP) NP_012578.1 518756 R 4932 CDS NP_012579.1 6322505 853503 complement(519631..521595) 1 NC_001142.7 Ssc1p; Mitochondrial matrix ATPase, subunit of the presequence translocase-associated protein import motor (PAM) and of SceI endonuclease; involved in protein folding and translocation into the matrix; phosphorylated; member of HSP70 family 521595 SSC1 853503 SSC1 Saccharomyces cerevisiae Mitochondrial matrix ATPase, subunit of the presequence translocase-associated protein import motor (PAM) and of SceI endonuclease; involved in protein folding and translocation into the matrix; phosphorylated; member of HSP70 family NP_012579.1 519631 R 4932 CDS NP_012580.1 6322506 853504 522041..523855 1 NC_001142.7 Tah11p; DNA replication licensing factor, required for pre-replication complex assembly 523855 TAH11 853504 TAH11 Saccharomyces cerevisiae DNA replication licensing factor, required for pre-replication complex assembly NP_012580.1 522041 D 4932 CDS NP_012581.1 6322507 853506 complement(524901..525374) 1 NC_001142.7 Translation initiation factor eIF-5A, promotes formation of the first peptide bond; similar to and functionally redundant with Hyp2p; undergoes an essential hypusination modification; expressed under anaerobic conditions; Anb1p 525374 ANB1 853506 ANB1 Saccharomyces cerevisiae Anb1p NP_012581.1 524901 R 4932 CDS NP_012582.1 6322508 853507 526328..526657 1 NC_001142.7 Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; Cyc1p 526657 CYC1 853507 CYC1 Saccharomyces cerevisiae Cyc1p NP_012582.1 526328 D 4932 CDS NP_012583.1 6322509 853508 complement(526877..528469) 1 NC_001142.7 Utr1p; ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p) 528469 UTR1 853508 UTR1 Saccharomyces cerevisiae ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p) NP_012583.1 526877 R 4932 CDS NP_012584.1 6322510 853509 528690..529397 1 NC_001142.7 Isy1p; Component of the spliceosome complex involved in pre-mRNA splicing, auxiliary splicing factor that may modulate Syf1p activity and help optimize splicing; isy1 syf2 double mutation activates the spindle checkpoint, causing cell cycle arrest 529397 ISY1 853509 ISY1 Saccharomyces cerevisiae Component of the spliceosome complex involved in pre-mRNA splicing, auxiliary splicing factor that may modulate Syf1p activity and help optimize splicing; isy1 syf2 double mutation activates the spindle checkpoint, causing cell cycle arrest NP_012584.1 528690 D 4932 CDS NP_012585.1 6322511 853510 529854..531359 1 NC_001142.7 Osm1p; Fumarate reductase, catalyzes the reduction of fumarate to succinate, required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity 531359 OSM1 853510 OSM1 Saccharomyces cerevisiae Fumarate reductase, catalyzes the reduction of fumarate to succinate, required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity NP_012585.1 529854 D 4932 CDS NP_012586.1 6322512 853512 532055..533752 1 NC_001142.7 Rad7p; Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex 533752 RAD7 853512 RAD7 Saccharomyces cerevisiae Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex NP_012586.1 532055 D 4932 CDS NP_012587.1 6322513 853513 534020..535744 1 NC_001142.7 Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis; Bfa1p 535744 BFA1 853513 BFA1 Saccharomyces cerevisiae Bfa1p NP_012587.1 534020 D 4932 CDS NP_012588.1 6322514 853514 536049..537542 1 NC_001142.7 Yjr054wp; Vacuolar protein of unknown function; potential Cdc28p substrate 537542 853514 YJR054W Saccharomyces cerevisiae Vacuolar protein of unknown function; potential Cdc28p substrate NP_012588.1 536049 D 4932 CDS NP_012589.1 6322515 853516 538765..539259 1 NC_001142.7 Protein of unknown function, required for growth at high temperature; Hit1p 539259 HIT1 853516 HIT1 Saccharomyces cerevisiae Hit1p NP_012589.1 538765 D 4932 CDS NP_012590.1 6322516 853518 complement(541785..542495) 1 NC_001142.7 Yjr056cp 542495 853518 YJR056C Saccharomyces cerevisiae Yjr056cp NP_012590.1 541785 R 4932 CDS NP_012591.1 6322517 853520 544055..544705 1 NC_001142.7 Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p; Cdc8p 544705 CDC8 853520 CDC8 Saccharomyces cerevisiae Cdc8p NP_012591.1 544055 D 4932 CDS NP_012592.1 6322518 853521 complement(544725..545168) 1 NC_001142.7 Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex; Aps2p 545168 APS2 853521 APS2 Saccharomyces cerevisiae Aps2p NP_012592.1 544725 R 4932 CDS NP_012593.1 6322519 853522 545780..548236 1 NC_001142.7 Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake; Ptk2p 548236 PTK2 853522 PTK2 Saccharomyces cerevisiae Ptk2p NP_012593.1 545780 D 4932 CDS NP_012594.1 6322520 853523 548752..549807 1 NC_001142.7 Helix-loop-helix protein that binds the motif CACRTG, which is present at several sites including MET gene promoters and centromere DNA element I (CDEI); required for nucleosome positioning at this motif; targets Isw1p to DNA; Cbf1p 549807 CBF1 853523 CBF1 Saccharomyces cerevisiae Cbf1p NP_012594.1 548752 D 4932 CDS NP_012595.1 6322521 853524 550504..553311 1 NC_001142.7 Yjr061wp; Putative protein of unknown function; non-essential gene with similarity to Mnn4, a putative membrane protein involved in glycosylation; transcription repressed by Rm101p 553311 853524 YJR061W Saccharomyces cerevisiae Putative protein of unknown function; non-essential gene with similarity to Mnn4, a putative membrane protein involved in glycosylation; transcription repressed by Rm101p NP_012595.1 550504 D 4932 CDS NP_012596.1 6322522 853525 complement(553469..554842) 1 NC_001142.7 Nta1p; Amidase, removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation 554842 NTA1 853525 NTA1 Saccharomyces cerevisiae Amidase, removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation NP_012596.1 553469 R 4932 CDS NP_012597.1 6322523 853526 555188..555565 1 NC_001142.7 Rpa12p; RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex 555565 RPA12 853526 RPA12 Saccharomyces cerevisiae RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex NP_012597.1 555188 D 4932 CDS NP_012598.1 6322524 853527 555907..557595 1 NC_001142.7 Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; Cct5p 557595 CCT5 853527 CCT5 Saccharomyces cerevisiae Cct5p NP_012598.1 555907 D 4932 CDS NP_012599.1 6322525 853528 complement(557802..559151) 1 NC_001142.7 Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity; Arp3p 559151 ARP3 853528 ARP3 Saccharomyces cerevisiae Arp3p NP_012599.1 557802 R 4932 CDS NP_012600.1 6322526 853529 559409..566821 1 NC_001142.7 Tor1p; PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis 566821 TOR1 853529 TOR1 Saccharomyces cerevisiae PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis NP_012600.1 559409 D 4932 CDS NP_012601.1 6322527 853530 complement(567012..567437) 1 NC_001142.7 Yae1p; Essential protein of unknown function 567437 YAE1 853530 YAE1 Saccharomyces cerevisiae Essential protein of unknown function NP_012601.1 567012 R 4932 CDS NP_012602.1 6322528 853531 567636..568697 1 NC_001142.7 Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; Rfc2p 568697 RFC2 853531 RFC2 Saccharomyces cerevisiae Rfc2p NP_012602.1 567636 D 4932 CDS NP_012603.1 6322529 853532 complement(568799..569392) 1 NC_001142.7 Ham1p; Conserved protein with deoxyribonucleoside triphosphate pyrophosphohydrolase activity, mediates exclusion of noncanonical purines from deoxyribonucleoside triphosphate pools; mutant is sensitive to the base analog 6-N-hydroxylaminopurine 569392 HAM1 853532 HAM1 Saccharomyces cerevisiae Conserved protein with deoxyribonucleoside triphosphate pyrophosphohydrolase activity, mediates exclusion of noncanonical purines from deoxyribonucleoside triphosphate pools; mutant is sensitive to the base analog 6-N-hydroxylaminopurine NP_012603.1 568799 R 4932 CDS NP_012604.1 6322531 853534 complement(569614..570591) 1 NC_001142.7 Lia1p; Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyses hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning 570591 LIA1 853534 LIA1 Saccharomyces cerevisiae Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyses hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning NP_012604.1 569614 R 4932 CDS NP_012606.1 6322532 853535 complement(570960..572117) 1 NC_001142.7 Npa3p; Essential, conserved, cytoplasmic ATPase; phosphorylated by the Pcl1p-Pho85p kinase complex 572117 NPA3 853535 NPA3 Saccharomyces cerevisiae Essential, conserved, cytoplasmic ATPase; phosphorylated by the Pcl1p-Pho85p kinase complex NP_012606.1 570960 R 4932 CDS NP_012607.1 6322533 853536 complement(572308..572928) 1 NC_001142.7 Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis; Opi3p 572928 OPI3 853536 OPI3 Saccharomyces cerevisiae Opi3p NP_012607.1 572308 R 4932 CDS NP_012608.1 6322534 853537 573088..573744 1 NC_001142.7 Mog1p; Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p 573744 MOG1 853537 MOG1 Saccharomyces cerevisiae Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p NP_012608.1 573088 D 4932 CDS NP_012609.1 6322535 853538 573974..575164 1 NC_001142.7 Hoc1p; Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele 575164 HOC1 853538 HOC1 Saccharomyces cerevisiae Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele NP_012609.1 573974 D 4932 CDS NP_012610.1 6322536 853539 complement(575347..576594) 1 NC_001142.7 Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM; Cdc11p 576594 CDC11 853539 CDC11 Saccharomyces cerevisiae Cdc11p NP_012610.1 575347 R 4932 CDS NP_012611.1 6322537 853540 complement(577248..578183) 1 NC_001142.7 Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated; Mir1p 578183 MIR1 853540 MIR1 Saccharomyces cerevisiae Mir1p NP_012611.1 577248 R 4932 CDS NP_012612.1 6322538 853541 578853..580214 1 NC_001142.7 Tryptophan 2,3-dioxygenase, required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway; Bna2p 580214 BNA2 853541 BNA2 Saccharomyces cerevisiae Bna2p NP_012612.1 578853 D 4932 CDS NP_012613.1 6322539 853542 join(580198..580340,581046..581232) 1 NC_001142.7 Yjr079wp; Putative protein of unknown function; mutation results in impaired mitochondrial respiration 581232 853542 YJR079W Saccharomyces cerevisiae Putative protein of unknown function; mutation results in impaired mitochondrial respiration NP_012613.1 580198 D 4932 CDS NP_012614.1 6322540 853543 complement(580425..581609) 1 NC_001142.7 Protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays increased frequency of mitochondrial genome loss and reduced growth rate in minimal glycerol media; Aim24p 581609 AIM24 853543 AIM24 Saccharomyces cerevisiae Aim24p NP_012614.1 580425 R 4932 CDS NP_012615.1 6322541 853544 complement(581907..582248) 1 NC_001142.7 Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3; Eaf6p 582248 EAF6 853544 EAF6 Saccharomyces cerevisiae Eaf6p NP_012615.1 581907 R 4932 CDS NP_012616.1 6322542 853545 complement(582601..583530) 1 NC_001142.7 Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate; Acf4p 583530 ACF4 853545 ACF4 Saccharomyces cerevisiae Acf4p NP_012616.1 582601 R 4932 CDS NP_012617.1 6322543 853546 583726..584997 1 NC_001142.7 Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; Csn12p 584997 CSN12 853546 CSN12 Saccharomyces cerevisiae Csn12p NP_012617.1 583726 D 4932 CDS NP_012618.1 6322544 853547 complement(585113..585430) 1 NC_001142.7 Yjr085cp; Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 585430 853547 YJR085C Saccharomyces cerevisiae Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_012618.1 585113 R 4932 CDS NP_012619.1 6322545 853548 586061..586393 1 NC_001142.7 Ste18p; G protein gamma subunit, forms a dimer with Ste4p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste4p to dampen signaling; C-terminus is palmitoylated and farnesylated, which are required for normal signaling 586393 STE18 853548 STE18 Saccharomyces cerevisiae G protein gamma subunit, forms a dimer with Ste4p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste4p to dampen signaling; C-terminus is palmitoylated and farnesylated, which are required for normal signaling NP_012619.1 586061 D 4932 CDS NP_012621.1 6322547 853550 complement(586488..587366) 1 NC_001142.7 Yjr088cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum 587366 853550 YJR088C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum NP_012621.1 586488 R 4932 CDS NP_012622.1 6322548 853551 587711..590575 1 NC_001142.7 Essential chromosomal passenger protein involved in coordinating cell cycle events for proper chromosome segregation; C-terminal region binds Sli15p, and the middle region, upon phosphorylation, localizes Cbf2p to the spindle at anaphase; Bir1p 590575 BIR1 853551 BIR1 Saccharomyces cerevisiae Bir1p NP_012622.1 587711 D 4932 CDS NP_012623.1 6322549 853552 complement(590865..594320) 1 NC_001142.7 Grr1p; F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification 594320 GRR1 853552 GRR1 Saccharomyces cerevisiae F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification NP_012623.1 590865 R 4932 CDS NP_012624.1 6322550 853553 complement(595054..598329) 1 NC_001142.7 Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; overexpression suppresses a tub2-150 mutation and causes increased sensitivity to benomyl in wild-type cells; Jsn1p 598329 JSN1 853553 JSN1 Saccharomyces cerevisiae Jsn1p NP_012624.1 595054 R 4932 CDS NP_012625.2 46562091 853554 598728..603074 1 NC_001142.7 Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding; potential Cdc28p substrate; Bud4p 603074 BUD4 853554 BUD4 Saccharomyces cerevisiae Bud4p NP_012625.2 598728 D 4932 CDS NP_012626.1 6322552 853555 complement(603216..604199) 1 NC_001142.7 Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; Fip1p 604199 FIP1 853555 FIP1 Saccharomyces cerevisiae Fip1p NP_012626.1 603216 R 4932 CDS NP_012627.1 6322553 853556 complement(604565..605647) 1 NC_001142.7 Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p; Ime1p 605647 IME1 853556 IME1 Saccharomyces cerevisiae Ime1p NP_012627.1 604565 R 4932 CDS NP_012628.1 6322554 853557 join(608301..608302,608578..608854) 1 NC_001142.7 Rpl43bp; Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein 608854 RPL43B 853557 RPL43B Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein NP_012628.1 608301 D 4932 CDS NP_012629.1 6322555 853558 609769..610737 1 NC_001142.7 Sfc1p; Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization 610737 SFC1 853558 SFC1 Saccharomyces cerevisiae Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization NP_012629.1 609769 D 4932 CDS NP_012630.1 6322556 853559 611191..612039 1 NC_001142.7 Yjr096wp; Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS 612039 853559 YJR096W Saccharomyces cerevisiae Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS NP_012630.1 611191 D 4932 CDS NP_012631.1 6322557 853560 612409..612927 1 NC_001142.7 Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein; Jjj3p 612927 JJJ3 853560 JJJ3 Saccharomyces cerevisiae Jjj3p NP_012631.1 612409 D 4932 CDS NP_012632.1 6322558 853561 complement(613182..615149) 1 NC_001142.7 Yjr098cp; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 615149 853561 YJR098C Saccharomyces cerevisiae Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_012632.1 613182 R 4932 CDS NP_012633.1 6322559 853562 615569..616279 1 NC_001142.7 Yuh1p; Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p 616279 YUH1 853562 YUH1 Saccharomyces cerevisiae Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p NP_012633.1 615569 D 4932 CDS NP_012634.1 6322560 853563 complement(616344..617327) 1 NC_001142.7 Putative protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays increased frequency of mitochondrial genome loss (petite formation); similar to murine NOR1; Aim25p 617327 AIM25 853563 AIM25 Saccharomyces cerevisiae Aim25p NP_012634.1 616344 R 4932 CDS NP_012635.1 6322561 853565 618227..619027 1 NC_001142.7 Rsm26p; Mitochondrial ribosomal protein of the small subunit 619027 RSM26 853565 RSM26 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the small subunit NP_012635.1 618227 D 4932 CDS NP_012636.1 6322562 853566 complement(619150..619758) 1 NC_001142.7 Vps25p; Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome 619758 VPS25 853566 VPS25 Saccharomyces cerevisiae Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome NP_012636.1 619150 R 4932 CDS NP_012637.1 6322563 853567 620747..622441 1 NC_001142.7 Ura8p; Minor CTP synthase isozyme (see also URA7), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis 622441 URA8 853567 URA8 Saccharomyces cerevisiae Minor CTP synthase isozyme (see also URA7), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis NP_012637.1 620747 D 4932 CDS NP_012638.1 6322564 853568 complement(622542..623006) 1 NC_001142.7 Sod1p; Cytosolic superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans 623006 SOD1 853568 SOD1 Saccharomyces cerevisiae Cytosolic superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans NP_012638.1 622542 R 4932 CDS NP_012639.1 6322565 853569 623573..624595 1 NC_001142.7 Ado1p; Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle 624595 ADO1 853569 ADO1 Saccharomyces cerevisiae Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle NP_012639.1 623573 D 4932 CDS NP_012640.1 6322566 853570 624830..627007 1 NC_001142.7 Non-essential protein of unknown function; Ecm27p 627007 ECM27 853570 ECM27 Saccharomyces cerevisiae Ecm27p NP_012640.1 624830 D 4932 CDS NP_012641.1 6322567 853571 627333..628319 1 NC_001142.7 Yjr107wp; Putative protein of unknown function; has sequence or structural similarity to lipases 628319 853571 YJR107W Saccharomyces cerevisiae Putative protein of unknown function; has sequence or structural similarity to lipases NP_012641.1 627333 D 4932 CDS NP_012642.1 6322568 853572 628706..629077 1 NC_001142.7 Protein of unknown function, required for normal microtubule organization; Abm1p 629077 ABM1 853572 ABM1 Saccharomyces cerevisiae Abm1p NP_012642.1 628706 D 4932 CDS NP_012643.1 6322569 853573 complement(629579..632935) 1 NC_001142.7 Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; Cpa2p 632935 CPA2 853573 CPA2 Saccharomyces cerevisiae Cpa2p NP_012643.1 629579 R 4932 CDS NP_012644.1 6322570 853574 633609..635675 1 NC_001142.7 Ymr1p; Phosphatidylinositol 3-phosphate [PI(3)P] phosphatase, regulates the localization and levels of PI(3)P; involved in cytoplasm to vacuole (CVT) transport; has similarity to the conserved myotubularin dual specificity phosphatase family 635675 YMR1 853574 YMR1 Saccharomyces cerevisiae Phosphatidylinositol 3-phosphate [PI(3)P] phosphatase, regulates the localization and levels of PI(3)P; involved in cytoplasm to vacuole (CVT) transport; has similarity to the conserved myotubularin dual specificity phosphatase family NP_012644.1 633609 D 4932 CDS NP_012645.1 6322571 853575 complement(635849..636700) 1 NC_001142.7 Yjr111cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria 636700 853575 YJR111C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria NP_012645.1 635849 R 4932 CDS NP_012646.1 6322572 853576 637024..637629 1 NC_001142.7 Nnf1p; Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation 637629 NNF1 853576 NNF1 Saccharomyces cerevisiae Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation NP_012646.1 637024 D 4932 CDS NP_878107.1 33438825 1466470 join(637784..637803,637853..638162) 1 NC_001142.7 Yjr112w-ap; Putative protein of unknown function; identified based on homology to Ashbya gossypii 638162 1466470 YJR112W-A Saccharomyces cerevisiae Putative protein of unknown function; identified based on homology to Ashbya gossypii NP_878107.1 637784 D 4932 CDS NP_012647.1 6322574 853578 complement(638226..638969) 1 NC_001142.7 Rsm7p; Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein 638969 RSM7 853578 RSM7 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein NP_012647.1 638226 R 4932 CDS NP_012649.1 6322575 853579 639936..640445 1 NC_001142.7 Yjr115wp; Putative protein of unknown function 640445 853579 YJR115W Saccharomyces cerevisiae Putative protein of unknown function NP_012649.1 639936 D 4932 CDS NP_012650.1 6322576 853580 640819..641658 1 NC_001142.7 Yjr116wp; Putative protein of unknown function 641658 853580 YJR116W Saccharomyces cerevisiae Putative protein of unknown function NP_012650.1 640819 D 4932 CDS NP_012651.1 6322577 853581 642001..643362 1 NC_001142.7 Ste24p; Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans 643362 STE24 853581 STE24 Saccharomyces cerevisiae Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans NP_012651.1 642001 D 4932 CDS NP_012652.1 6322578 853582 complement(643484..644095) 1 NC_001142.7 Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth; Ilm1p 644095 ILM1 853582 ILM1 Saccharomyces cerevisiae Ilm1p NP_012652.1 643484 R 4932 CDS NP_012653.1 6322579 853583 complement(644298..646484) 1 NC_001142.7 JmjC domain family histone demethylase specific for H3-K4 (lysine at position 4 of the histone H3 protein); removes methyl groups specifically added by Set1p methyltransferase; Jhd2p 646484 JHD2 853583 JHD2 Saccharomyces cerevisiae Jhd2p NP_012653.1 644298 R 4932 CDS NP_012654.1 6322580 853584 647120..647470 1 NC_001142.7 Yjr120wp; Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p 647470 853584 YJR120W Saccharomyces cerevisiae Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p NP_012654.1 647120 D 4932 CDS NP_012655.1 6322581 853585 647601..649136 1 NC_001142.7 Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated; Atp2p 649136 ATP2 853585 ATP2 Saccharomyces cerevisiae Atp2p NP_012655.1 647601 D 4932 CDS NP_012656.1 6322582 853586 649770..651263 1 NC_001142.7 Mitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system; Iba57p 651263 IBA57 853586 IBA57 Saccharomyces cerevisiae Iba57p NP_012656.1 649770 D 4932 CDS NP_012657.1 6322583 853587 651895..652572 1 NC_001142.7 Rps5p; Protein component of the small (40S) ribosomal subunit, the least basic of the non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; has similarity to E. coli S7 and rat S5 ribosomal proteins 652572 RPS5 853587 RPS5 Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit, the least basic of the non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; has similarity to E. coli S7 and rat S5 ribosomal proteins NP_012657.1 651895 D 4932 CDS NP_012658.1 6322584 853588 complement(652886..654232) 1 NC_001142.7 Yjr124cp; Putative protein of unknown function; expression induced under calcium shortage 654232 853588 YJR124C Saccharomyces cerevisiae Putative protein of unknown function; expression induced under calcium shortage NP_012658.1 652886 R 4932 CDS NP_012659.1 6322585 853589 complement(654731..655957) 1 NC_001142.7 Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p; Ent3p 655957 ENT3 853589 ENT3 Saccharomyces cerevisiae Ent3p NP_012659.1 654731 R 4932 CDS NP_012660.1 6322586 853590 complement(656248..658683) 1 NC_001142.7 Vps70p; Protein of unknown function involved in vacuolar protein sorting 658683 VPS70 853590 VPS70 Saccharomyces cerevisiae Protein of unknown function involved in vacuolar protein sorting NP_012660.1 656248 R 4932 CDS NP_012661.1 6322588 853592 complement(658911..663053) 1 NC_001142.7 Zinc-finger protein involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; Rsf2p 663053 RSF2 853592 RSF2 Saccharomyces cerevisiae Rsf2p NP_012661.1 658911 R 4932 CDS NP_012663.1 6322589 853593 complement(663994..665013) 1 NC_001142.7 Yjr129cp; Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 665013 853593 YJR129C Saccharomyces cerevisiae Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm NP_012663.1 663994 R 4932 CDS NP_012664.1 6322590 853594 complement(665212..667131) 1 NC_001142.7 Str2p; Cystathionine gamma-synthase, converts cysteine into cystathionine 667131 STR2 853594 STR2 Saccharomyces cerevisiae Cystathionine gamma-synthase, converts cysteine into cystathionine NP_012664.1 665212 R 4932 CDS NP_012665.1 6322591 853595 667638..669287 1 NC_001142.7 Mns1p; Alpha-1,2-mannosidase involved in ER quality control; catalyzes the removal of one mannose residue from Man9GlcNAc to produce a single isomer of Man8GlcNAc in N-linked oligosaccharide biosynthesis; integral to ER membrane 669287 MNS1 853595 MNS1 Saccharomyces cerevisiae Alpha-1,2-mannosidase involved in ER quality control; catalyzes the removal of one mannose residue from Man9GlcNAc to produce a single isomer of Man8GlcNAc in N-linked oligosaccharide biosynthesis; integral to ER membrane NP_012665.1 667638 D 4932 CDS NP_012666.1 6322592 853596 669516..672662 1 NC_001142.7 Nmd5p; Karyopherin, a carrier protein involved in nuclear import of proteins; importin beta homolog 672662 NMD5 853596 NMD5 Saccharomyces cerevisiae Karyopherin, a carrier protein involved in nuclear import of proteins; importin beta homolog NP_012666.1 669516 D 4932 CDS NP_012667.1 6322593 853597 672985..673614 1 NC_001142.7 Xpt1p; Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine 673614 XPT1 853597 XPT1 Saccharomyces cerevisiae Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine NP_012667.1 672985 D 4932 CDS NP_012668.1 6322594 853598 complement(673723..675846) 1 NC_001142.7 Sgm1p; Protein of unknown function, required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus 675846 SGM1 853598 SGM1 Saccharomyces cerevisiae Protein of unknown function, required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus NP_012668.1 673723 R 4932 CDS NP_012669.1 6322595 853599 complement(676053..676772) 1 NC_001142.7 Protein involved in minichromosome maintenance; component of the kinetochore; binds to centromeric DNA in a Ctf19p-dependent manner; Mcm22p 676772 MCM22 853599 MCM22 Saccharomyces cerevisiae Mcm22p NP_012669.1 676053 R 4932 CDS NP_058168.1 7839183 853600 676965..677228 1 NC_001142.7 Tim8p; Mitochondrial intermembrane space protein mediating import and insertion of polytopic inner membrane proteins; homolog of human DDP1 (deafness dystonia peptide 1) which is mutated in the X-linked Mohr-Tranebjaerg syndrome 677228 TIM8 853600 TIM8 Saccharomyces cerevisiae Mitochondrial intermembrane space protein mediating import and insertion of polytopic inner membrane proteins; homolog of human DDP1 (deafness dystonia peptide 1) which is mutated in the X-linked Mohr-Tranebjaerg syndrome NP_058168.1 676965 D 4932 CDS NP_012670.1 6322596 853601 complement(677435..678700) 1 NC_001142.7 Yjr136cp; Putative protein of unknown function; may interact with mitochondrial ribosomal protein Rsm23p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 678700 853601 YJR136C Saccharomyces cerevisiae Putative protein of unknown function; may interact with mitochondrial ribosomal protein Rsm23p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm NP_012670.1 677435 R 4932 CDS NP_116579.1 14318438 853602 complement(678951..683279) 1 NC_001142.7 Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine; Ecm17p 683279 ECM17 853602 ECM17 Saccharomyces cerevisiae Ecm17p NP_116579.1 678951 R 4932 CDS NP_012672.1 6322598 853603 684561..689315 1 NC_001142.7 Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; Iml1p 689315 IML1 853603 IML1 Saccharomyces cerevisiae Iml1p NP_012672.1 684561 D 4932 CDS NP_012673.1 6322599 853604 complement(689439..690518) 1 NC_001142.7 Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions; Hom6p 690518 HOM6 853604 HOM6 Saccharomyces cerevisiae Hom6p NP_012673.1 689439 R 4932 CDS NP_012674.1 6322600 853605 complement(690744..695690) 1 NC_001142.7 Transcriptional corepressor involved in the cell cycle-regulated transcription of histone genes HTA1, HTB1, HHT1, and HHT2; involved in position-dependent gene silencing and nucleosome reassembly; Hir3p 695690 HIR3 853605 HIR3 Saccharomyces cerevisiae Hir3p NP_012674.1 690744 R 4932 CDS NP_012675.1 6322601 853606 695900..696943 1 NC_001142.7 Yjr141wp; Putative protein of unknown function; may be involved in mRNA processing; YJR141W is an essential gene 696943 853606 YJR141W Saccharomyces cerevisiae Putative protein of unknown function; may be involved in mRNA processing; YJR141W is an essential gene NP_012675.1 695900 D 4932 CDS NP_012676.1 6322602 853607 697135..698163 1 NC_001142.7 Yjr142wp; Putative protein of unknown function; GST fusion protein is a Dbf2-Mob1 phosphoylation target in a proteome chip analysis; synthetic lethal with PH085 deletion 698163 853607 YJR142W Saccharomyces cerevisiae Putative protein of unknown function; GST fusion protein is a Dbf2-Mob1 phosphoylation target in a proteome chip analysis; synthetic lethal with PH085 deletion NP_012676.1 697135 D 4932 CDS NP_012677.1 6322603 853608 complement(698320..700608) 1 NC_001142.7 Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; appears to form homodimers in vivo and does not complex with other Pmt proteins; target for new antifungals; Pmt4p 700608 PMT4 853608 PMT4 Saccharomyces cerevisiae Pmt4p NP_012677.1 698320 R 4932 CDS NP_012678.1 6322604 853609 700876..701685 1 NC_001142.7 Protein involved in mitochondrial genome maintenance; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage; Mgm101p 701685 MGM101 853609 MGM101 Saccharomyces cerevisiae Mgm101p NP_012678.1 700876 D 4932 CDS NP_012679.1 6322605 853610 complement(join(702021..702792,703049..703062)) 1 NC_001142.7 Rps4ap; Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; identical to Rps4Bp and has similarity to rat S4 ribosomal protein 703062 RPS4A 853610 RPS4A Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; identical to Rps4Bp and has similarity to rat S4 ribosomal protein NP_012679.1 702021 R 4932 CDS NP_012681.1 6322607 853612 704190..705266 1 NC_001142.7 Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; Hms2p 705266 HMS2 853612 HMS2 Saccharomyces cerevisiae Hms2p NP_012681.1 704190 D 4932 CDS NP_012682.1 6322608 853613 705738..706868 1 NC_001142.7 Cytosolic branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase; Bat2p 706868 BAT2 853613 BAT2 Saccharomyces cerevisiae Bat2p NP_012682.1 705738 D 4932 CDS NP_012683.1 6322609 853614 707154..708368 1 NC_001142.7 Yjr149wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 708368 853614 YJR149W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm NP_012683.1 707154 D 4932 CDS NP_012684.1 6322610 853615 complement(708805..709701) 1 NC_001142.7 Dan1p; Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth 709701 DAN1 853615 DAN1 Saccharomyces cerevisiae Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth NP_012684.1 708805 R 4932 CDS NP_012685.1 6322611 853616 complement(712249..715734) 1 NC_001142.7 Dan4p; Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth 715734 DAN4 853616 DAN4 Saccharomyces cerevisiae Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth NP_012685.1 712249 R 4932 CDS NP_878108.1 33438826 1466471 717574..717624 1 NC_001142.7 Yjr151w-ap; Putative protein of unknown function; identified by fungal homology and RT-PCR 717624 1466471 YJR151W-A Saccharomyces cerevisiae Putative protein of unknown function; identified by fungal homology and RT-PCR NP_878108.1 717574 D 4932 CDS NP_012686.1 6322612 853617 719660..721291 1 NC_001142.7 Dal5p; Allantoin permease; ureidosuccinate permease; expression is constitutive but sensitive to nitrogen catabolite repression 721291 DAL5 853617 DAL5 Saccharomyces cerevisiae Allantoin permease; ureidosuccinate permease; expression is constitutive but sensitive to nitrogen catabolite repression NP_012686.1 719660 D 4932 CDS NP_012687.1 6322613 853618 722809..723894 1 NC_001142.7 Pgu1p; Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins 723894 PGU1 853618 PGU1 Saccharomyces cerevisiae Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins NP_012687.1 722809 D 4932 CDS NP_012688.1 6322614 853619 725778..726818 1 NC_001142.7 Yjr154wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 726818 853619 YJR154W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm NP_012688.1 725778 D 4932 CDS NP_012689.1 6322615 853620 727399..728265 1 NC_001142.7 Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; Aad10p 728265 AAD10 853620 AAD10 Saccharomyces cerevisiae Aad10p NP_012689.1 727399 D 4932 CDS NP_012690.1 6322616 853621 complement(728568..729590) 1 NC_001142.7 Thi11p; Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13 729590 THI11 853621 THI11 Saccharomyces cerevisiae Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13 NP_012690.1 728568 R 4932 CDS NP_012692.1 6322618 853623 732434..734137 1 NC_001142.7 Protein of unknown function with similarity to hexose transporter family members, expression is repressed by high levels of glucose; Hxt16p 734137 HXT16 853623 HXT16 Saccharomyces cerevisiae Hxt16p NP_012692.1 732434 D 4932 CDS NP_012693.1 6322619 853624 736038..737111 1 NC_001142.7 Sorbitol dehydrogenase; expression is induced in the presence of sorbitol; Sor1p 737111 SOR1 853624 SOR1 Saccharomyces cerevisiae Sor1p NP_012693.1 736038 D 4932 CDS NP_012694.1 6322620 853625 complement(738002..739810) 1 NC_001142.7 Mph3p; Alpha-glucoside permease, transports maltose, maltotriose, alpha-methylglucoside, and turanose; identical to Mph2p; encoded in a subtelomeric position in a region likely to have undergone duplication 739810 MPH3 853625 MPH3 Saccharomyces cerevisiae Alpha-glucoside permease, transports maltose, maltotriose, alpha-methylglucoside, and turanose; identical to Mph2p; encoded in a subtelomeric position in a region likely to have undergone duplication NP_012694.1 738002 R 4932 CDS NP_012695.1 6322621 853626 complement(742842..743993) 1 NC_001142.7 Protein of unknown function, member the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; Cos5p 743993 COS5 853626 COS5 Saccharomyces cerevisiae Cos5p NP_012695.1 742842 R 4932 CDS NP_012698.1 6322625 853656 complement(1811..2182) 1 NC_001143.7 Putative protein of unknown function; Pau16p 2182 PAU16 853656 PAU16 Saccharomyces cerevisiae Pau16p NP_012698.1 1811 R 4932 CDS NP_012700.1 6322627 853658 complement(3504..5621) 1 NC_001143.7 Ykl222cp; Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine 5621 853658 YKL222C Saccharomyces cerevisiae Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine NP_012700.1 3504 R 4932 CDS NP_012701.1 6322628 853659 6108..7529 1 NC_001143.7 Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport; Mch2p 7529 MCH2 853659 MCH2 Saccharomyces cerevisiae Mch2p NP_012701.1 6108 D 4932 CDS NP_012702.1 6322629 853660 complement(9092..11227) 1 NC_001143.7 Fre2p; Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels 11227 FRE2 853660 FRE2 Saccharomyces cerevisiae Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels NP_012702.1 9092 R 4932 CDS NP_012703.1 6322630 853661 14485..15708 1 NC_001143.7 Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; Cos9p 15708 COS9 853661 COS9 Saccharomyces cerevisiae Cos9p NP_012703.1 14485 D 4932 CDS NP_012704.1 6322631 853662 complement(17359..18339) 1 NC_001143.7 Sry1p; 3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate 18339 SRY1 853662 SRY1 Saccharomyces cerevisiae 3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate NP_012704.1 17359 R 4932 CDS NP_012705.1 6322632 853663 22234..24084 1 NC_001143.7 Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose; Jen1p 24084 JEN1 853663 JEN1 Saccharomyces cerevisiae Jen1p NP_012705.1 22234 D 4932 CDS NP_012706.1 6322633 853664 25216..26160 1 NC_001143.7 Ura1p; Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid 26160 URA1 853664 URA1 Saccharomyces cerevisiae Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid NP_012706.1 25216 D 4932 CDS NP_012707.1 6322634 853665 complement(26828..30688) 1 NC_001143.7 Ykl215cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 30688 853665 YKL215C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm NP_012707.1 26828 R 4932 CDS NP_012708.1 6322635 853666 complement(31083..31694) 1 NC_001143.7 Yra2p; Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleus 31694 YRA2 853666 YRA2 Saccharomyces cerevisiae Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleus NP_012708.1 31083 R 4932 CDS NP_012709.1 6322636 853667 complement(31961..34108) 1 NC_001143.7 WD repeat protein required for ubiquitin-mediated protein degradation, forms complex with Cdc48p, plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; Doa1p 34108 DOA1 853667 DOA1 Saccharomyces cerevisiae Doa1p NP_012709.1 31961 R 4932 CDS NP_012710.1 6322637 853668 34544..36415 1 NC_001143.7 Sac1p; Phosphatidylinositol (PI) phosphatase, involved in hydrolysis of PI 3-phosphate, PI 4-phosphate and PI 3,5-bisphosphate to PI; membrane protein localizes to ER and Golgi; involved in protein trafficking, secretion and inositol metabolism 36415 SAC1 853668 SAC1 Saccharomyces cerevisiae Phosphatidylinositol (PI) phosphatase, involved in hydrolysis of PI 3-phosphate, PI 4-phosphate and PI 3,5-bisphosphate to PI; membrane protein localizes to ER and Golgi; involved in protein trafficking, secretion and inositol metabolism NP_012710.1 34544 D 4932 CDS NP_012711.1 6322638 853669 complement(36700..38154) 1 NC_001143.7 Trp3p; Bifunctional enzyme exhibiting both indole-3-glycerol-phosphate synthase and anthranilate synthase activities, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p 38154 TRP3 853669 TRP3 Saccharomyces cerevisiae Bifunctional enzyme exhibiting both indole-3-glycerol-phosphate synthase and anthranilate synthase activities, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p NP_012711.1 36700 R 4932 CDS NP_012712.1 6322639 853670 39164..42238 1 NC_001143.7 Ubiquitin activating enzyme (E1), involved in ubiquitin-mediated protein degradation and essential for viability; Uba1p 42238 UBA1 853670 UBA1 Saccharomyces cerevisiae Uba1p NP_012712.1 39164 D 4932 CDS NP_012713.1 6322640 853671 complement(42424..46296) 1 NC_001143.7 Ste6p; Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells 46296 STE6 853671 STE6 Saccharomyces cerevisiae Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells NP_012713.1 42424 R 4932 CDS NP_012714.1 6322641 853673 47158..47973 1 NC_001143.7 Protein involved in 5' end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p; Cbt1p 47973 CBT1 853673 CBT1 Saccharomyces cerevisiae Cbt1p NP_012714.1 47158 D 4932 CDS NP_012715.3 99030926 853628 48195..48956 1 NC_001143.7 Putative protein of unknown function; non-essential gene; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media; Lrc3p 48956 LRC3 853628 LRC3 Saccharomyces cerevisiae Lrc3p NP_012715.3 48195 D 4932 CDS NP_012716.1 6322643 853629 complement(49007..49810) 1 NC_001143.7 Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly; Add66p 49810 ADD66 853629 ADD66 Saccharomyces cerevisiae Add66p NP_012716.1 49007 R 4932 CDS NP_012717.1 6322644 853630 50052..53354 1 NC_001143.7 Nuclear pore protein involved in nuclear export of pre-tRNA; Los1p 53354 LOS1 853630 LOS1 Saccharomyces cerevisiae Los1p NP_012717.1 50052 D 4932 CDS NP_012718.1 6322645 853631 53705..55603 1 NC_001143.7 eIF4E-associated protein, binds eIF4E and inhibits cap-dependent translation, also functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade; Eap1p 55603 EAP1 853631 EAP1 Saccharomyces cerevisiae Eap1p NP_012718.1 53705 D 4932 CDS NP_012719.2 42759860 853632 complement(55936..63360) 1 NC_001143.7 Tor2p; PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis 63360 TOR2 853632 TOR2 Saccharomyces cerevisiae PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis NP_012719.2 55936 R 4932 CDS NP_012721.1 6322648 853634 complement(63931..67467) 1 NC_001143.7 Putative positive regulator of mannosylphosphate transferase (Mnn6p), involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; Mnn4p 67467 MNN4 853634 MNN4 Saccharomyces cerevisiae Mnn4p NP_012721.1 63931 R 4932 CDS NP_012723.2 27808711 853635 complement(68274..70223) 1 NC_001143.7 Putative serine/threonine protein kinase that regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein; Ptk1p 70223 PTK1 853635 PTK1 Saccharomyces cerevisiae Ptk1p NP_012723.2 68274 R 4932 CDS NP_012724.1 6322651 853636 complement(70739..73870) 1 NC_001143.7 Pex1p; AAA-peroxin that heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis 73870 PEX1 853636 PEX1 Saccharomyces cerevisiae AAA-peroxin that heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis NP_012724.1 70739 R 4932 CDS NP_012725.1 6322652 853638 complement(74937..75539) 1 NC_001143.7 Ykt6p; Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus 75539 YKT6 853638 YKT6 Saccharomyces cerevisiae Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus NP_012725.1 74937 R 4932 CDS NP_012726.2 37362671 853639 75826..77037 1 NC_001143.7 Mia40p; Essential protein of the mitochondrial intermembrane space (IMS); promotes retention of newly imported proteins; may do so by stabilizing client protein folding as part of a disulfide relay system or transferring metal to client proteins 77037 MIA40 853639 MIA40 Saccharomyces cerevisiae Essential protein of the mitochondrial intermembrane space (IMS); promotes retention of newly imported proteins; may do so by stabilizing client protein folding as part of a disulfide relay system or transferring metal to client proteins NP_012726.2 75826 D 4932 CDS NP_012727.1 6322654 853640 complement(77263..78651) 1 NC_001143.7 Mst1p; Mitochondrial threonyl-tRNA synthetase 78651 MST1 853640 MST1 Saccharomyces cerevisiae Mitochondrial threonyl-tRNA synthetase NP_012727.1 77263 R 4932 CDS NP_012728.1 6322655 853641 complement(78871..79887) 1 NC_001143.7 Sds22p; Conserved nuclear regulatory subunit of Glc7p type 1 protein serine-threonine phosphatase (PP1), functions positively with Glc7p to promote dephosphorylation of nuclear substrates required for chromosome transmission during mitosis 79887 SDS22 853641 SDS22 Saccharomyces cerevisiae Conserved nuclear regulatory subunit of Glc7p type 1 protein serine-threonine phosphatase (PP1), functions positively with Glc7p to promote dephosphorylation of nuclear substrates required for chromosome transmission during mitosis NP_012728.1 78871 R 4932 CDS NP_012729.1 6322656 853642 complement(80165..80542) 1 NC_001143.7 Mitochondrial matrix acyl carrier protein, involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p; Acp1p 80542 ACP1 853642 ACP1 Saccharomyces cerevisiae Acp1p NP_012729.1 80165 R 4932 CDS NP_012730.1 6322657 853643 81040..82644 1 NC_001143.7 Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p; Dph2p 82644 DPH2 853643 DPH2 Saccharomyces cerevisiae Dph2p NP_012730.1 81040 D 4932 CDS NP_012731.1 6322658 853644 join(82952..83003,83080..83555) 1 NC_001143.7 Cnb1p; Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1 83555 CNB1 853644 CNB1 Saccharomyces cerevisiae Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1 NP_012731.1 82952 D 4932 CDS NP_012732.1 6322659 853646 84709..85908 1 NC_001143.7 Hym1p; Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response 85908 HYM1 853646 HYM1 Saccharomyces cerevisiae Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response NP_012732.1 84709 D 4932 CDS NP_012733.1 6322660 853647 complement(86230..88791) 1 NC_001143.7 Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins; Pxa2p 88791 PXA2 853647 PXA2 Saccharomyces cerevisiae Pxa2p NP_012733.1 86230 R 4932 CDS NP_012734.1 6322661 853648 complement(89289..91541) 1 NC_001143.7 Ykl187cp; Putative protein of unknown function; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies 91541 853648 YKL187C Saccharomyces cerevisiae Putative protein of unknown function; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies NP_012734.1 89289 R 4932 CDS NP_012735.1 6322662 853649 complement(92749..93303) 1 NC_001143.7 mRNA transport regulator, essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA; Mtr2p 93303 MTR2 853649 MTR2 Saccharomyces cerevisiae Mtr2p NP_012735.1 92749 R 4932 CDS NP_012736.1 6322663 853650 94504..96270 1 NC_001143.7 Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate; Ash1p 96270 ASH1 853650 ASH1 Saccharomyces cerevisiae Ash1p NP_012736.1 94504 D 4932 CDS NP_012737.1 6322664 853651 96762..98162 1 NC_001143.7 Spe1p; Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines 98162 SPE1 853651 SPE1 Saccharomyces cerevisiae Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines NP_012737.1 96762 D 4932 CDS NP_878109.1 33578046 1500485 complement(98400..98612) 1 NC_001143.7 Ykl183c-ap; Putative protein of unknown function; identified by fungal homology and RT-PCR 98612 1500485 YKL183C-A Saccharomyces cerevisiae Putative protein of unknown function; identified by fungal homology and RT-PCR NP_878109.1 98400 R 4932 CDS NP_012738.1 6322665 853652 98726..99646 1 NC_001143.7 Protein of unknown function; gene expression increases in cultures shifted to a lower temperature; Lot5p 99646 LOT5 853652 LOT5 Saccharomyces cerevisiae Lot5p NP_012738.1 98726 D 4932 CDS NP_012739.1 6322666 853653 100676..106831 1 NC_001143.7 Fas1p; Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities 106831 FAS1 853653 FAS1 Saccharomyces cerevisiae Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities NP_012739.1 100676 D 4932 CDS NP_012740.1 6322667 853654 107321..108604 1 NC_001143.7 Prs1p; 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involved in nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes 108604 PRS1 853654 PRS1 Saccharomyces cerevisiae 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involved in nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes NP_012740.1 107321 D 4932 CDS NP_012741.1 6322668 853674 join(109274..109582,109889..110134) 1 NC_001143.7 Rpl17ap; Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Bp and has similarity to E. coli L22 and rat L17 ribosomal proteins; copurifies with the Dam1 complex (aka DASH complex) 110134 RPL17A 853674 RPL17A Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Bp and has similarity to E. coli L22 and rat L17 ribosomal proteins; copurifies with the Dam1 complex (aka DASH complex) NP_012741.1 109274 D 4932 CDS NP_012742.1 6322669 853675 complement(110469..112508) 1 NC_001143.7 Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function; Coy1p 112508 COY1 853675 COY1 Saccharomyces cerevisiae Coy1p NP_012742.1 110469 R 4932 CDS NP_012743.1 6322671 853677 complement(113220..114632) 1 NC_001143.7 Ste3p; Receptor for a factor receptor, transcribed in alpha cells and required for mating by alpha cells, couples to MAP kinase cascade to mediate pheromone response; ligand bound receptors are endocytosed and recycled to the plasma membrane; GPCR 114632 STE3 853677 STE3 Saccharomyces cerevisiae Receptor for a factor receptor, transcribed in alpha cells and required for mating by alpha cells, couples to MAP kinase cascade to mediate pheromone response; ligand bound receptors are endocytosed and recycled to the plasma membrane; GPCR NP_012743.1 113220 R 4932 CDS NP_012745.1 6322672 853678 complement(115505..117991) 1 NC_001143.7 Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface; Lst4p 117991 LST4 853678 LST4 Saccharomyces cerevisiae Lst4p NP_012745.1 115505 R 4932 CDS NP_012746.1 6322673 853679 118798..120309 1 NC_001143.7 Zrt3p; Vacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency 120309 ZRT3 853679 ZRT3 Saccharomyces cerevisiae Vacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency NP_012746.1 118798 D 4932 CDS NP_012747.1 6322674 853680 complement(120385..122241) 1 NC_001143.7 Tpo5p; Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles 122241 TPO5 853680 TPO5 Saccharomyces cerevisiae Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles NP_012747.1 120385 R 4932 CDS NP_012748.1 6322675 853681 122522..125548 1 NC_001143.7 Snu114p; GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2 125548 SNU114 853681 SNU114 Saccharomyces cerevisiae GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2 NP_012748.1 122522 D 4932 CDS NP_012749.1 6322676 853682 125764..127047 1 NC_001143.7 Essential protein required for the maturation of 25S rRNA and 60S ribosomal subunit assembly, localizes to the nucleolus; constituent of 66S pre-ribosomal particles; Ebp2p 127047 EBP2 853682 EBP2 Saccharomyces cerevisiae Ebp2p NP_012749.1 125764 D 4932 CDS NP_012750.1 6322677 853683 127480..130266 1 NC_001143.7 Ykl171wp; Putative protein of unknown function; predicted protein kinase; implicated in proteasome function; epitope-tagged protein localizes to the cytoplasm 130266 853683 YKL171W Saccharomyces cerevisiae Putative protein of unknown function; predicted protein kinase; implicated in proteasome function; epitope-tagged protein localizes to the cytoplasm NP_012750.1 127480 D 4932 CDS NP_012751.1 6322678 853684 130639..131055 1 NC_001143.7 Mrpl38p; Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels 131055 MRPL38 853684 MRPL38 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels NP_012751.1 130639 D 4932 CDS NP_012753.2 99030927 853686 complement(131293..133467) 1 NC_001143.7 Putative serine/threonine protein kinase with unknown cellular role; Kkq8p 133467 KKQ8 853686 KKQ8 Saccharomyces cerevisiae Kkq8p NP_012753.2 131293 R 4932 CDS NP_012754.1 6322681 853687 complement(133726..134139) 1 NC_001143.7 Mrp49p; Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation 134139 MRP49 853687 MRP49 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation NP_012754.1 133726 R 4932 CDS NP_012755.1 6322682 853688 complement(134514..135710) 1 NC_001143.7 cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk1p and Tpk2p; Tpk3p 135710 TPK3 853688 TPK3 Saccharomyces cerevisiae Tpk3p NP_012755.1 134514 R 4932 CDS NP_012756.1 6322683 853690 complement(137937..140696) 1 NC_001143.7 Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes; Mcd4p 140696 MCD4 853690 MCD4 Saccharomyces cerevisiae Mcd4p NP_012756.1 137937 R 4932 CDS NP_012757.1 6322684 853692 complement(141799..142824) 1 NC_001143.7 Pir1p; O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle 142824 PIR1 853692 PIR1 Saccharomyces cerevisiae O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle NP_012757.1 141799 R 4932 CDS NP_012758.1 6322685 853693 144406..145383 1 NC_001143.7 Pir3p; O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway 145383 PIR3 853693 PIR3 Saccharomyces cerevisiae O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway NP_012758.1 144406 D 4932 CDS NP_012760.1 6322687 853695 complement(147635..148843) 1 NC_001143.7 Ykl162cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion 148843 853695 YKL162C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion NP_012760.1 147635 R 4932 CDS NP_012761.1 6322688 853696 complement(149391..150692) 1 NC_001143.7 Ykl161cp; Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; associates with Rlm1p 150692 853696 YKL161C Saccharomyces cerevisiae Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; associates with Rlm1p NP_012761.1 149391 R 4932 CDS NP_012762.1 6322689 853697 153274..153711 1 NC_001143.7 Transcription elongation factor that contains a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression; Elf1p 153711 ELF1 853697 ELF1 Saccharomyces cerevisiae Elf1p NP_012762.1 153274 D 4932 CDS NP_012763.1 6322690 853698 complement(153821..154456) 1 NC_001143.7 Rcn1p; Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region 154456 RCN1 853698 RCN1 Saccharomyces cerevisiae Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region NP_012763.1 153821 R 4932 CDS NP_012765.2 9755335 853699 join(154996..155276,155660..158186) 1 NC_001143.7 Zinc-dependent metallopeptidase yscII, may have a role in obtaining leucine from dipeptide substrates; sequence coordinates have changed since RT-PCR analysis showed that the adjacent ORF YKL158W comprises the 5' exon of APE2/YKL157W; Ape2p 158186 APE2 853699 APE2 Saccharomyces cerevisiae Ape2p NP_012765.2 154996 D 4932 CDS NP_012766.1 6322693 853700 join(158619..158621,158972..159217) 1 NC_001143.7 Rps27ap; Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Bp and has similarity to rat S27 ribosomal protein 159217 RPS27A 853700 RPS27A Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Bp and has similarity to rat S27 ribosomal protein NP_012766.1 158619 D 4932 CDS NP_012767.1 6322694 853701 complement(159461..161347) 1 NC_001143.7 Rsm22p; Mitochondrial ribosomal protein of the small subunit 161347 RSM22 853701 RSM22 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the small subunit NP_012767.1 159461 R 4932 CDS NP_012768.1 6322695 853702 161606..162340 1 NC_001143.7 Srp102p; Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors Srp101p to the ER membrane 162340 SRP102 853702 SRP102 Saccharomyces cerevisiae Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors Srp101p to the ER membrane NP_012768.1 161606 D 4932 CDS NP_012770.1 6322697 853705 complement(163647..164390) 1 NC_001143.7 Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis; Gpm1p 164390 GPM1 853705 GPM1 Saccharomyces cerevisiae Gpm1p NP_012770.1 163647 R 4932 CDS NP_012771.1 6322698 853706 complement(164922..165935) 1 NC_001143.7 Ykl151cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 165935 853706 YKL151C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm NP_012771.1 164922 R 4932 CDS NP_012772.1 6322699 853707 166549..167457 1 NC_001143.7 Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis; Mcr1p 167457 MCR1 853707 MCR1 Saccharomyces cerevisiae Mcr1p NP_012772.1 166549 D 4932 CDS NP_012773.1 6322700 853708 complement(167617..168834) 1 NC_001143.7 RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition; Dbr1p 168834 DBR1 853708 DBR1 Saccharomyces cerevisiae Dbr1p NP_012773.1 167617 R 4932 CDS NP_012774.1 6322701 853709 complement(169212..171134) 1 NC_001143.7 Sdh1p; Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone 171134 SDH1 853709 SDH1 Saccharomyces cerevisiae Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone NP_012774.1 169212 R 4932 CDS NP_012776.1 6322702 853710 171788..173866 1 NC_001143.7 Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; Avt3p 173866 AVT3 853710 AVT3 Saccharomyces cerevisiae Avt3p NP_012776.1 171788 D 4932 CDS NP_012777.1 6322704 853712 174218..175621 1 NC_001143.7 Rpt1p; One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and the E3 ubiquitin-protein ligase Ubr1p 175621 RPT1 853712 RPT1 Saccharomyces cerevisiae One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and the E3 ubiquitin-protein ligase Ubr1p NP_012777.1 174218 D 4932 CDS NP_012778.1 6322705 853713 complement(175848..176486) 1 NC_001143.7 Rpc25p; RNA polymerase III subunit C25 176486 RPC25 853713 RPC25 Saccharomyces cerevisiae RNA polymerase III subunit C25 NP_012778.1 175848 R 4932 CDS NP_012779.1 6322706 853714 176786..178177 1 NC_001143.7 Ltv1p; Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature 178177 LTV1 853714 LTV1 Saccharomyces cerevisiae Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature NP_012779.1 176786 D 4932 CDS NP_012780.1 6322707 853715 178520..179179 1 NC_001143.7 Putative mitochondrial ribosomal protein, has similarity to E. coli ribosomal protein S2; Mrp8p 179179 MRP8 853715 MRP8 Saccharomyces cerevisiae Mrp8p NP_012780.1 178520 D 4932 CDS NP_012781.1 6322708 853716 179672..180268 1 NC_001143.7 Sdh3p; Cytochrome b subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone 180268 SDH3 853716 SDH3 Saccharomyces cerevisiae Cytochrome b subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone NP_012781.1 179672 D 4932 CDS NP_012782.1 6322709 853717 180784..182430 1 NC_001143.7 Tgl1p; Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes 182430 TGL1 853717 TGL1 Saccharomyces cerevisiae Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes NP_012782.1 180784 D 4932 CDS NP_012783.1 6322710 853718 182963..184549 1 NC_001143.7 Ctk1p; Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing 184549 CTK1 853718 CTK1 Saccharomyces cerevisiae Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing NP_012783.1 182963 D 4932 CDS NP_690844.1 23270398 853719 complement(184808..185017) 1 NC_001143.7 Hsk3p; Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis 185017 HSK3 853719 HSK3 Saccharomyces cerevisiae Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis NP_690844.1 184808 R 4932 CDS NP_012784.1 6322711 853720 complement(185291..185686) 1 NC_001143.7 Mrpl31p; Mitochondrial ribosomal protein of the large subunit 185686 MRPL31 853720 MRPL31 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit NP_012784.1 185291 R 4932 CDS NP_012785.2 83722563 853721 185962..186297 1 NC_001143.7 Putative protein of unknown function; mutation results in growth defect on a non-fermentable (respiratory) carbon source; Cmc1p 186297 CMC1 853721 CMC1 Saccharomyces cerevisiae Cmc1p NP_012785.2 185962 D 4932 CDS NP_012787.1 6322714 853723 complement(186465..188645) 1 NC_001143.7 Beta-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; Apl2p 188645 APL2 853723 APL2 Saccharomyces cerevisiae Apl2p NP_012787.1 186465 R 4932 CDS NP_012788.1 6322715 853724 complement(189129..191441) 1 NC_001143.7 Oct1p; Mitochondrial intermediate peptidase, cleaves N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis 191441 OCT1 853724 OCT1 Saccharomyces cerevisiae Mitochondrial intermediate peptidase, cleaves N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis NP_012788.1 189129 R 4932 CDS NP_012789.1 6322716 853725 complement(191678..193069) 1 NC_001143.7 Ykl133cp; Putative protein of unknown function 193069 853725 YKL133C Saccharomyces cerevisiae Putative protein of unknown function NP_012789.1 191678 R 4932 CDS NP_012790.1 6322718 853727 complement(193573..194865) 1 NC_001143.7 Rma1p; Putative dihydrofolate synthetase; has similarity to Fol3p and to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 194865 RMA1 853727 RMA1 Saccharomyces cerevisiae Putative dihydrofolate synthetase; has similarity to Fol3p and to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_012790.1 193573 R 4932 CDS NP_012792.1 6322719 853728 complement(195287..196027) 1 NC_001143.7 She2p; RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud 196027 SHE2 853728 SHE2 Saccharomyces cerevisiae RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud NP_012792.1 195287 R 4932 CDS NP_012793.1 6322720 853729 complement(196348..200163) 1 NC_001143.7 One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization; Myo3p 200163 MYO3 853729 MYO3 Saccharomyces cerevisiae Myo3p NP_012793.1 196348 R 4932 CDS NP_012794.1 6322721 853730 complement(200528..201415) 1 NC_001143.7 Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant; Pmu1p 201415 PMU1 853730 PMU1 Saccharomyces cerevisiae Pmu1p NP_012794.1 200528 R 4932 CDS NP_012795.1 6322722 853732 203185..204897 1 NC_001143.7 Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; Pgm1p 204897 PGM1 853732 PGM1 Saccharomyces cerevisiae Pgm1p NP_012795.1 203185 D 4932 CDS NP_012796.1 6322723 853733 205351..207393 1 NC_001143.7 Ypk1p; Serine/threonine protein kinase required for receptor-mediated endocytosis; involved in sphingolipid-mediated and cell integrity signaling pathways; localized to the bud neck, cytosol and plasma membrane; homolog of mammalian kinase SGK 207393 YPK1 853733 YPK1 Saccharomyces cerevisiae Serine/threonine protein kinase required for receptor-mediated endocytosis; involved in sphingolipid-mediated and cell integrity signaling pathways; localized to the bud neck, cytosol and plasma membrane; homolog of mammalian kinase SGK NP_012796.1 205351 D 4932 CDS NP_012797.1 6322724 853734 207891..209774 1 NC_001143.7 Rrn3p; Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA 209774 RRN3 853734 RRN3 Saccharomyces cerevisiae Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA NP_012797.1 207891 D 4932 CDS NP_012798.1 6322725 853735 210237..211976 1 NC_001143.7 Vacuolar protein that presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; Ssh4p 211976 SSH4 853735 SSH4 Saccharomyces cerevisiae Ssh4p NP_012798.1 210237 D 4932 CDS NP_012800.1 6322727 853737 complement(212139..212642) 1 NC_001143.7 Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm; Srp21p 212642 SRP21 853737 SRP21 Saccharomyces cerevisiae Srp21p NP_012800.1 212139 R 4932 CDS NP_012801.1 6322728 853738 213786..216344 1 NC_001143.7 Ykl121wp; Putative protein of unknown function 216344 853738 YKL121W Saccharomyces cerevisiae Putative protein of unknown function NP_012801.1 213786 D 4932 CDS NP_012802.1 6322729 853739 216988..217962 1 NC_001143.7 Oac1p; Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, and thiosulfate; member of the mitochondrial carrier family 217962 OAC1 853739 OAC1 Saccharomyces cerevisiae Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, and thiosulfate; member of the mitochondrial carrier family NP_012802.1 216988 D 4932 CDS NP_012803.1 6322731 853741 complement(218214..218861) 1 NC_001143.7 Vph2p; Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER) 218861 VPH2 853741 VPH2 Saccharomyces cerevisiae Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER) NP_012803.1 218214 R 4932 CDS NP_012805.1 6322732 853743 219968..220618 1 NC_001143.7 Sba1p; Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins and like p23 can regulate telomerase activity 220618 SBA1 853743 SBA1 Saccharomyces cerevisiae Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins and like p23 can regulate telomerase activity NP_012805.1 219968 D 4932 CDS NP_012806.1 6322733 853744 complement(220988..222544) 1 NC_001143.7 Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; Prr1p 222544 PRR1 853744 PRR1 Saccharomyces cerevisiae Prr1p NP_012806.1 220988 R 4932 CDS NP_012808.1 6322735 853746 complement(222996..224099) 1 NC_001143.7 Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine; Apn1p 224099 APN1 853746 APN1 Saccharomyces cerevisiae Apn1p NP_012808.1 222996 R 4932 CDS NP_012809.1 6322736 853747 complement(224371..225519) 1 NC_001143.7 Rad27p; 5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family 225519 RAD27 853747 RAD27 Saccharomyces cerevisiae 5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family NP_012809.1 224371 R 4932 CDS NP_012810.1 6322737 853748 226214..228409 1 NC_001143.7 DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair; Abf1p 228409 ABF1 853748 ABF1 Saccharomyces cerevisiae Abf1p NP_012810.1 226214 D 4932 CDS NP_012812.1 6322739 853750 complement(228583..229524) 1 NC_001143.7 Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p; Kti12p 229524 KTI12 853750 KTI12 Saccharomyces cerevisiae Kti12p NP_012812.1 228583 R 4932 CDS NP_012813.1 6322740 853751 231871..233535 1 NC_001143.7 Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex; Hap4p 233535 HAP4 853751 HAP4 Saccharomyces cerevisiae Hap4p NP_012813.1 231871 D 4932 CDS NP_012814.1 6322741 853752 234070..235431 1 NC_001143.7 Sld2p; Protein required for DNA replication, phosphorylated in S phase by S-phase cyclin-dependent kinases (Cdks), phosphorylation is essential for DNA replication and for complex formation with Dpb11p; potential Cdc28p substrate 235431 SLD2 853752 SLD2 Saccharomyces cerevisiae Protein required for DNA replication, phosphorylated in S phase by S-phase cyclin-dependent kinases (Cdks), phosphorylation is essential for DNA replication and for complex formation with Dpb11p; potential Cdc28p substrate NP_012814.1 234070 D 4932 CDS NP_012815.1 6322742 853753 235785..236714 1 NC_001143.7 Ykl107wp; Putative protein of unknown function 236714 853753 YKL107W Saccharomyces cerevisiae Putative protein of unknown function NP_012815.1 235785 D 4932 CDS NP_076898.1 13129176 853754 complement(236791..236910) 1 NC_001143.7 Ykl106c-ap; Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi 236910 853754 YKL106C-A Saccharomyces cerevisiae Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi NP_076898.1 236791 R 4932 CDS NP_012816.1 6322743 853755 237180..238535 1 NC_001143.7 Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis; Aat1p 238535 AAT1 853755 AAT1 Saccharomyces cerevisiae Aat1p NP_012816.1 237180 D 4932 CDS NP_012817.1 6322744 853756 complement(238829..242227) 1 NC_001143.7 Ykl105cp; Putative protein of unknown function 242227 853756 YKL105C Saccharomyces cerevisiae Putative protein of unknown function NP_012817.1 238829 R 4932 CDS NP_012818.1 6322745 853757 complement(242864..245017) 1 NC_001143.7 Glutamine-fructose-6-phosphate amidotransferase, catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; Gfa1p 245017 GFA1 853757 GFA1 Saccharomyces cerevisiae Gfa1p NP_012818.1 242864 R 4932 CDS NP_012819.1 6322746 853758 complement(245782..247326) 1 NC_001143.7 Vacuolar aminopeptidase, often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway; Lap4p 247326 LAP4 853758 LAP4 Saccharomyces cerevisiae Lap4p NP_012819.1 245782 R 4932 CDS NP_012821.1 6322748 853760 248564..253120 1 NC_001143.7 Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p; Hsl1p 253120 HSL1 853760 HSL1 Saccharomyces cerevisiae Hsl1p NP_012821.1 248564 D 4932 CDS NP_012822.1 6322749 853761 complement(253341..255104) 1 NC_001143.7 Ykl100cp; Putative protein of unknown function with similarity to a human minor histocompatibility antigen; YKL100C is not an essential gene 255104 853761 YKL100C Saccharomyces cerevisiae Putative protein of unknown function with similarity to a human minor histocompatibility antigen; YKL100C is not an essential gene NP_012822.1 253341 R 4932 CDS NP_012823.2 83722564 853762 complement(255364..256116) 1 NC_001143.7 Utp11p; Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA 256116 UTP11 853762 UTP11 Saccharomyces cerevisiae Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA NP_012823.2 255364 R 4932 CDS NP_012824.1 6322751 853763 256414..257487 1 NC_001143.7 Ykl098wp; Putative protein of unknown function 257487 853763 YKL098W Saccharomyces cerevisiae Putative protein of unknown function NP_012824.1 256414 D 4932 CDS NP_878110.1 33578047 1500486 complement(258717..258866) 1 NC_001143.7 Ykl096c-bp; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 258866 1500486 YKL096C-B Saccharomyces cerevisiae Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching NP_878110.1 258717 R 4932 CDS NP_012826.1 6322753 853765 258897..259175 1 NC_001143.7 Cwp2p; Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored 259175 CWP2 853765 CWP2 Saccharomyces cerevisiae Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored NP_012826.1 258897 D 4932 CDS NP_012827.1 6322754 853766 260776..261495 1 NC_001143.7 Cwp1p; Cell wall mannoprotein, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; involved in cell wall organization 261495 CWP1 853766 CWP1 Saccharomyces cerevisiae Cell wall mannoprotein, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; involved in cell wall organization NP_012827.1 260776 D 4932 CDS NP_012828.1 6322755 853767 261921..262757 1 NC_001143.7 Yju2p; Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC ('nineteen complex') and acts after Prp2p to promote the first catalytic reaction of splicing 262757 YJU2 853767 YJU2 Saccharomyces cerevisiae Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC ('nineteen complex') and acts after Prp2p to promote the first catalytic reaction of splicing NP_012828.1 261921 D 4932 CDS NP_012829.1 6322756 853768 262993..263934 1 NC_001143.7 Yju3p; Serine hydrolase with sequence similarity to monoglyceride lipase (MGL), localizes to lipid particles 263934 YJU3 853768 YJU3 Saccharomyces cerevisiae Serine hydrolase with sequence similarity to monoglyceride lipase (MGL), localizes to lipid particles NP_012829.1 262993 D 4932 CDS NP_012830.1 6322757 853769 264433..265452 1 NC_001143.7 Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; Mbr1p 265452 MBR1 853769 MBR1 Saccharomyces cerevisiae Mbr1p NP_012830.1 264433 D 4932 CDS NP_012831.1 6322758 853770 complement(265789..269103) 1 NC_001143.7 GTPase activating factor for Rsr1p/Bud1p required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types; Bud2p 269103 BUD2 853770 BUD2 Saccharomyces cerevisiae Bud2p NP_012831.1 265789 R 4932 CDS NP_012832.1 6322759 853771 complement(269362..270294) 1 NC_001143.7 Ykl091cp; Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus 270294 853771 YKL091C Saccharomyces cerevisiae Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus NP_012832.1 269362 R 4932 CDS NP_012833.1 6322760 853772 271522..272853 1 NC_001143.7 Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination; Cue2p 272853 CUE2 853772 CUE2 Saccharomyces cerevisiae Cue2p NP_012833.1 271522 D 4932 CDS NP_012834.1 6322761 853773 273038..274687 1 NC_001143.7 Mif2p; Kinetochore protein with homology to human CENP-C, required for structural integrity of the spindle during anaphase spindle elongation, interacts with histones H2A, H2B, and H4, phosphorylated by Ipl1p 274687 MIF2 853773 MIF2 Saccharomyces cerevisiae Kinetochore protein with homology to human CENP-C, required for structural integrity of the spindle during anaphase spindle elongation, interacts with histones H2A, H2B, and H4, phosphorylated by Ipl1p NP_012834.1 273038 D 4932 CDS NP_012835.1 6322762 853774 274927..276642 1 NC_001143.7 Ykl088wp; Predicted phosphopantothenoylcysteine decarboxylase, may be involved in coenzyme A biosynthesis; interacts with Sis2p and Vhs3p 276642 853774 YKL088W Saccharomyces cerevisiae Predicted phosphopantothenoylcysteine decarboxylase, may be involved in coenzyme A biosynthesis; interacts with Sis2p and Vhs3p NP_012835.1 274927 D 4932 CDS NP_012836.1 6322763 853775 complement(276833..277507) 1 NC_001143.7 Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1; Cyt2p 277507 CYT2 853775 CYT2 Saccharomyces cerevisiae Cyt2p NP_012836.1 276833 R 4932 CDS NP_012837.1 6322764 853776 277925..278308 1 NC_001143.7 Sulfiredoxin, contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxins Tsa1p and Ahp1p that are formed upon exposure to oxidants; conserved in higher eukaryotes; Srx1p 278308 SRX1 853776 SRX1 Saccharomyces cerevisiae Srx1p NP_012837.1 277925 D 4932 CDS NP_012838.1 6322765 853777 278767..279771 1 NC_001143.7 Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated; Mdh1p 279771 MDH1 853777 MDH1 Saccharomyces cerevisiae Mdh1p NP_012838.1 278767 D 4932 CDS NP_012839.1 6322766 853778 280153..280503 1 NC_001143.7 Mitochondrial intermembrane space protein, first component of a pathway mediating assembly of small TIM (Translocase of the Inner Membrane) complexes which escort hydrophobic inner membrane proteins en route to the TIM22 complex; Hot13p 280503 HOT13 853778 HOT13 Saccharomyces cerevisiae Hot13p NP_012839.1 280153 D 4932 CDS NP_012841.1 6322768 853780 complement(280669..281973) 1 NC_001143.7 Rrp14p; Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family 281973 RRP14 853780 RRP14 Saccharomyces cerevisiae Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family NP_012841.1 280669 R 4932 CDS NP_012842.1 6322769 853781 join(282535..282739,283066..284099) 1 NC_001143.7 Translation elongation factor EF-1 gamma; Tef4p 284099 TEF4 853781 TEF4 Saccharomyces cerevisiae Tef4p NP_012842.1 282535 D 4932 CDS NP_012843.1 6322770 853782 284674..285852 1 NC_001143.7 Vma5p; Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane 285852 VMA5 853782 VMA5 Saccharomyces cerevisiae Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane NP_012843.1 284674 D 4932 CDS NP_012844.1 6322771 853783 286247..288217 1 NC_001143.7 Smy1p; Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is related to the motor domain of kinesins 288217 SMY1 853783 SMY1 Saccharomyces cerevisiae Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is related to the motor domain of kinesins NP_012844.1 286247 D 4932 CDS NP_012845.1 6322772 853784 288489..290696 1 NC_001143.7 Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis; Dhr2p 290696 DHR2 853784 DHR2 Saccharomyces cerevisiae Dhr2p NP_012845.1 288489 D 4932 CDS NP_012846.1 6322773 853785 291097..292275 1 NC_001143.7 Ykl077wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole 292275 853785 YKL077W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole NP_012846.1 291097 D 4932 CDS NP_012848.1 6322775 853787 complement(292600..293952) 1 NC_001143.7 Ykl075cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin 293952 853787 YKL075C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin NP_012848.1 292600 R 4932 CDS NP_012849.1 6322776 853788 complement(294254..295837) 1 NC_001143.7 Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65; Mud2p 295837 MUD2 853788 MUD2 Saccharomyces cerevisiae Mud2p NP_012849.1 294254 R 4932 CDS NP_012850.1 6322777 853789 296074..298719 1 NC_001143.7 Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; member of the Hsp70 family; localizes to the lumen of the ER; regulated by the unfolded protein response pathway; Lhs1p 298719 LHS1 853789 LHS1 Saccharomyces cerevisiae Lhs1p NP_012850.1 296074 D 4932 CDS NP_012851.1 6322778 853790 299226..301526 1 NC_001143.7 Stb6p; Protein that binds Sin3p in a two-hybrid assay 301526 STB6 853790 STB6 Saccharomyces cerevisiae Protein that binds Sin3p in a two-hybrid assay NP_012851.1 299226 D 4932 CDS NP_012852.1 6322779 853792 304758..305528 1 NC_001143.7 Ykl071wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 305528 853792 YKL071W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm NP_012852.1 304758 D 4932 CDS NP_012853.1 6322780 853793 305855..306364 1 NC_001143.7 Ykl070wp; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 306364 853793 YKL070W Saccharomyces cerevisiae Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_012853.1 305855 D 4932 CDS NP_012854.1 6322781 853794 306929..307471 1 NC_001143.7 Ykl069wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus 307471 853794 YKL069W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus NP_012854.1 306929 D 4932 CDS NP_878111.1 33578048 1500487 308850..309086 1 NC_001143.7 Ykl068w-ap; Putative protein of unknown function; identified by homology to Ashbya gossypii 309086 1500487 YKL068W-A Saccharomyces cerevisiae Putative protein of unknown function; identified by homology to Ashbya gossypii NP_878111.1 308850 D 4932 CDS NP_012855.1 6322782 853796 309843..312722 1 NC_001143.7 Subunit of the nuclear pore complex (NPC) that is localized to both sides of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup116p; Nup100p 312722 NUP100 853796 NUP100 Saccharomyces cerevisiae Nup100p NP_012855.1 309843 D 4932 CDS NP_012856.1 6322783 853798 314456..314917 1 NC_001143.7 Ynk1p; Nucleoside diphosphate kinase, catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate 314917 YNK1 853798 YNK1 Saccharomyces cerevisiae Nucleoside diphosphate kinase, catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate NP_012856.1 314456 D 4932 CDS NP_001032580.1 82795257 3799975 315598..315819 1 NC_001143.7 Ykl065w-ap; Putative protein of unknown function 315819 3799975 YKL065W-A Saccharomyces cerevisiae Putative protein of unknown function NP_001032580.1 315598 D 4932 CDS NP_012858.1 6322785 853800 complement(316081..316701) 1 NC_001143.7 Yet1p; Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein 316701 YET1 853800 YET1 Saccharomyces cerevisiae Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein NP_012858.1 316081 R 4932 CDS NP_012859.1 6322786 853801 317408..320317 1 NC_001143.7 Putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations; Mnr2p 320317 MNR2 853801 MNR2 Saccharomyces cerevisiae Mnr2p NP_012859.1 317408 D 4932 CDS NP_012860.1 6322787 853802 complement(320659..321162) 1 NC_001143.7 Ykl063cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi 321162 853802 YKL063C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi NP_012860.1 320659 R 4932 CDS NP_012861.1 6322788 853803 322872..324764 1 NC_001143.7 Transcriptional activator related to Msn2p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; Msn4p 324764 MSN4 853803 MSN4 Saccharomyces cerevisiae Msn4p NP_012861.1 322872 D 4932 CDS NP_012862.1 6322789 853804 325415..325756 1 NC_001143.7 Ykl061wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endosome 325756 853804 YKL061W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endosome NP_012862.1 325415 D 4932 CDS NP_012863.1 6322790 853805 complement(326052..327131) 1 NC_001143.7 Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress; Fba1p 327131 FBA1 853805 FBA1 Saccharomyces cerevisiae Fba1p NP_012863.1 326052 R 4932 CDS NP_012864.1 6322791 853806 complement(327762..329087) 1 NC_001143.7 Mpe1p; Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif 329087 MPE1 853806 MPE1 Saccharomyces cerevisiae Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif NP_012864.1 327762 R 4932 CDS NP_012865.1 6322792 853807 329810..330178 1 NC_001143.7 Toa2p; TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA 330178 TOA2 853807 TOA2 Saccharomyces cerevisiae TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA NP_012865.1 329810 D 4932 CDS NP_012866.1 6322793 853808 complement(330500..333613) 1 NC_001143.7 Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), required for even distribution of NPCs around the nuclear envelope, involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; Nup120p 333613 NUP120 853808 NUP120 Saccharomyces cerevisiae Nup120p NP_012866.1 330500 R 4932 CDS NP_012867.1 6322794 853809 complement(334056..334559) 1 NC_001143.7 Tma19p; Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress 334559 TMA19 853809 TMA19 Saccharomyces cerevisiae Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress NP_012867.1 334056 R 4932 CDS NP_012868.1 6322795 853810 complement(334965..335801) 1 NC_001143.7 Oar1p; Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase, may comprise a type II mitochondrial fatty acid synthase along with Mct1p 335801 OAR1 853810 OAR1 Saccharomyces cerevisiae Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase, may comprise a type II mitochondrial fatty acid synthase along with Mct1p NP_012868.1 334965 R 4932 CDS NP_012869.1 6322796 853811 complement(336181..338397) 1 NC_001143.7 RNAPII degradation factor, forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; Def1p 338397 DEF1 853811 DEF1 Saccharomyces cerevisiae Def1p NP_012869.1 336181 R 4932 CDS NP_012870.1 6322797 853812 complement(338826..339086) 1 NC_001143.7 Mitochondrial intermembrane space cysteine motif protein; mutation affects mitochondrial distribution and morphology; Mdm35p 339086 MDM35 853812 MDM35 Saccharomyces cerevisiae Mdm35p NP_012870.1 338826 R 4932 CDS NP_012872.1 6322799 853814 complement(339312..340190) 1 NC_001143.7 Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases; Ask1p 340190 ASK1 853814 ASK1 Saccharomyces cerevisiae Ask1p NP_012872.1 339312 R 4932 CDS NP_012873.1 6322800 853815 340956..342017 1 NC_001143.7 Sfk1p; Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane 342017 SFK1 853815 SFK1 Saccharomyces cerevisiae Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane NP_012873.1 340956 D 4932 CDS NP_012874.1 6322801 853816 complement(342496..345264) 1 NC_001143.7 Ykl050cp; Protein of unknown function; the YKL050W protein is a target of the SCFCdc4 ubiquitin ligase complex and YKL050W transcription is regulated by Azf1p 345264 853816 YKL050C Saccharomyces cerevisiae Protein of unknown function; the YKL050W protein is a target of the SCFCdc4 ubiquitin ligase complex and YKL050W transcription is regulated by Azf1p NP_012874.1 342496 R 4932 CDS NP_012875.2 27808712 853817 complement(345719..346408) 1 NC_001143.7 Cse4p; Centromere protein that resembles histones, required for proper kinetochore function; homolog of human CENP-A 346408 CSE4 853817 CSE4 Saccharomyces cerevisiae Centromere protein that resembles histones, required for proper kinetochore function; homolog of human CENP-A NP_012875.2 345719 R 4932 CDS NP_012876.1 6322803 853818 complement(346858..348780) 1 NC_001143.7 Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases; forms part of the bud neck ring; Elm1p 348780 ELM1 853818 ELM1 Saccharomyces cerevisiae Elm1p NP_012876.1 346858 R 4932 CDS NP_012877.1 6322804 853819 349107..350657 1 NC_001143.7 Ykl047wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 350657 853819 YKL047W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm NP_012877.1 349107 D 4932 CDS NP_012878.1 6322805 853820 complement(350919..352268) 1 NC_001143.7 Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p; Dcw1p 352268 DCW1 853820 DCW1 Saccharomyces cerevisiae Dcw1p NP_012878.1 350919 R 4932 CDS NP_012879.1 6322806 853821 353137..354723 1 NC_001143.7 Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair; Pri2p 354723 PRI2 853821 PRI2 Saccharomyces cerevisiae Pri2p NP_012879.1 353137 D 4932 CDS NP_012881.1 6322808 853823 356392..357492 1 NC_001143.7 Transcriptional activator that enhances pseudohyphal growth; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate; Phd1p 357492 PHD1 853823 PHD1 Saccharomyces cerevisiae Phd1p NP_012881.1 356392 D 4932 CDS NP_012882.1 6322809 853824 358119..359210 1 NC_001143.7 Spc42p; Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane 359210 SPC42 853824 SPC42 Saccharomyces cerevisiae Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane NP_012882.1 358119 D 4932 CDS NP_012883.1 6322810 853825 359786..360460 1 NC_001143.7 Vps24p; One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway 360460 VPS24 853825 VPS24 Saccharomyces cerevisiae One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway NP_012883.1 359786 D 4932 CDS NP_012884.1 6322811 853826 complement(360701..361471) 1 NC_001143.7 Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria; Nfu1p 361471 NFU1 853826 NFU1 Saccharomyces cerevisiae Nfu1p NP_012884.1 360701 R 4932 CDS NP_012885.2 83722565 853827 362265..363836 1 NC_001143.7 Ptm1p; Protein of unknown function, copurifies with late Golgi vesicles containing the v-SNARE Tlg2p 363836 PTM1 853827 PTM1 Saccharomyces cerevisiae Protein of unknown function, copurifies with late Golgi vesicles containing the v-SNARE Tlg2p NP_012885.2 362265 D 4932 CDS NP_012886.1 6322813 853828 365248..368760 1 NC_001143.7 Rgt1p; Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor 368760 RGT1 853828 RGT1 Saccharomyces cerevisiae Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor NP_012886.1 365248 D 4932 CDS NP_012887.1 6322814 853829 369008..369364 1 NC_001143.7 Putative protein of unknown function; null mutant is viable and displays increased frequency of mitochondrial genome loss (petite formation); Aim26p 369364 AIM26 853829 AIM26 Saccharomyces cerevisiae Aim26p NP_012887.1 369008 D 4932 CDS NP_012889.1 6322815 853830 369534..371033 1 NC_001143.7 Ugp1p; UDP-glucose pyrophosphorylase (UGPase), catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p 371033 UGP1 853830 UGP1 Saccharomyces cerevisiae UDP-glucose pyrophosphorylase (UGPase), catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p NP_012889.1 369534 D 4932 CDS NP_012890.1 6322817 853832 371472..373748 1 NC_001143.7 Tul1p; Golgi-localized RING-finger ubiquitin ligase (E3), involved in ubiquitinating and sorting membrane proteins that contain polar transmembrane domains to multivesicular bodies for delivery to the vacuole for quality control purposes 373748 TUL1 853832 TUL1 Saccharomyces cerevisiae Golgi-localized RING-finger ubiquitin ligase (E3), involved in ubiquitinating and sorting membrane proteins that contain polar transmembrane domains to multivesicular bodies for delivery to the vacuole for quality control purposes NP_012890.1 371472 D 4932 CDS NP_012891.2 42759861 853833 374148..374858 1 NC_001143.7 Ykl033w-ap; Putative protein of unknown function; similar to uncharacterized proteins from other fungi 374858 853833 YKL033W-A Saccharomyces cerevisiae Putative protein of unknown function; similar to uncharacterized proteins from other fungi NP_012891.2 374148 D 4932 CDS NP_012892.1 6322819 853834 375099..378215 1 NC_001143.7 Ykl033wp; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YKL033W is an essential gene 378215 853834 YKL033W Saccharomyces cerevisiae Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YKL033W is an essential gene NP_012892.1 375099 D 4932 CDS NP_012893.1 6322820 853836 complement(379708..381501) 1 NC_001143.7 Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b; Ixr1p 381501 IXR1 853836 IXR1 Saccharomyces cerevisiae Ixr1p NP_012893.1 379708 R 4932 CDS NP_012896.1 6322823 853839 complement(382359..384368) 1 NC_001143.7 Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids; Mae1p 384368 MAE1 853839 MAE1 Saccharomyces cerevisiae Mae1p NP_012896.1 382359 R 4932 CDS NP_012897.1 6322824 853840 385401..386849 1 NC_001143.7 Tfa1p; TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening 386849 TFA1 853840 TFA1 Saccharomyces cerevisiae TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening NP_012897.1 385401 D 4932 CDS NP_012898.1 6322825 853841 387205..388548 1 NC_001143.7 Ykl027wp; Protein of unknown function, localized to the mitochondrial outer membrane 388548 853841 YKL027W Saccharomyces cerevisiae Protein of unknown function, localized to the mitochondrial outer membrane NP_012898.1 387205 D 4932 CDS NP_012899.1 6322826 853842 complement(389023..389526) 1 NC_001143.7 Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; Gpx1p 389526 GPX1 853842 GPX1 Saccharomyces cerevisiae Gpx1p NP_012899.1 389023 R 4932 CDS NP_012900.1 6322827 853843 complement(389883..391922) 1 NC_001143.7 Pan3p; Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes 391922 PAN3 853843 PAN3 Saccharomyces cerevisiae Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes NP_012900.1 389883 R 4932 CDS NP_012901.1 6322828 853844 complement(392169..392783) 1 NC_001143.7 Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP); Ura6p 392783 URA6 853844 URA6 Saccharomyces cerevisiae Ura6p NP_012901.1 392169 R 4932 CDS NP_001032581.1 82795258 3799976 complement(392789..393016) 1 NC_001143.7 Ykl023c-ap; Putative protein of unknown function 393016 3799976 YKL023C-A Saccharomyces cerevisiae Putative protein of unknown function NP_001032581.1 392789 R 4932 CDS NP_012902.1 6322829 853845 393364..394197 1 NC_001143.7 Ykl023wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 394197 853845 YKL023W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm NP_012902.1 393364 D 4932 CDS NP_012903.1 6322830 853846 complement(394369..396891) 1 NC_001143.7 Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation; Cdc16p 396891 CDC16 853846 CDC16 Saccharomyces cerevisiae Cdc16p NP_012903.1 394369 R 4932 CDS NP_012904.1 6322831 853847 complement(396987..398393) 1 NC_001143.7 Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats; Mak11p 398393 MAK11 853847 MAK11 Saccharomyces cerevisiae Mak11p NP_012904.1 396987 R 4932 CDS NP_012905.1 6322832 853848 complement(398475..401723) 1 NC_001143.7 Spt23p; ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Mga2p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting 401723 SPT23 853848 SPT23 Saccharomyces cerevisiae ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Mga2p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting NP_012905.1 398475 R 4932 CDS NP_012906.1 6322833 853849 402211..403161 1 NC_001143.7 Ram2p; Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor 403161 RAM2 853849 RAM2 Saccharomyces cerevisiae Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor NP_012906.1 402211 D 4932 CDS NP_076899.1 13129177 853850 complement(403223..403522) 1 NC_001143.7 Ykl018c-ap; Putative protein of unknown function; identified by homology; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 403522 853850 YKL018C-A Saccharomyces cerevisiae Putative protein of unknown function; identified by homology; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm NP_076899.1 403223 R 4932 CDS NP_012907.1 6322834 853851 403745..404734 1 NC_001143.7 Swd2p; Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination 404734 SWD2 853851 SWD2 Saccharomyces cerevisiae Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination NP_012907.1 403745 D 4932 CDS NP_012908.1 6322835 853852 complement(404833..406884) 1 NC_001143.7 Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities; Hcs1p 406884 HCS1 853852 HCS1 Saccharomyces cerevisiae Hcs1p NP_012908.1 404833 R 4932 CDS NP_012909.1 6322836 853853 complement(407108..407632) 1 NC_001143.7 Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; Atp7p 407632 ATP7 853853 ATP7 Saccharomyces cerevisiae Atp7p NP_012909.1 407108 R 4932 CDS NP_012910.1 6322837 853854 408187..411126 1 NC_001143.7 Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences and undergoes a conformational change to form the active state; has a Zn(2)-Cys(6) binuclear cluster domain; Put3p 411126 PUT3 853854 PUT3 Saccharomyces cerevisiae Put3p NP_012910.1 408187 D 4932 CDS NP_012911.1 6322838 853855 complement(411262..416556) 1 NC_001143.7 Urb1p; Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit 416556 URB1 853855 URB1 Saccharomyces cerevisiae Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit NP_012911.1 411262 R 4932 CDS NP_012912.1 6322839 853856 complement(417151..417666) 1 NC_001143.7 Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; Arc19p 417666 ARC19 853856 ARC19 Saccharomyces cerevisiae Arc19p NP_012912.1 417151 R 4932 CDS NP_012913.1 6322840 853857 417953..419704 1 NC_001143.7 U1 snRNP protein involved in splicing, interacts with the branchpoint-binding protein during the formation of the second commitment complex; Prp40p 419704 PRP40 853857 PRP40 Saccharomyces cerevisiae Prp40p NP_012913.1 417953 D 4932 CDS NP_012914.1 6322841 853858 complement(419798..420859) 1 NC_001143.7 Mitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA; Cce1p 420859 CCE1 853858 CCE1 Saccharomyces cerevisiae Cce1p NP_012914.1 419798 R 4932 CDS NP_012915.1 6322842 853859 complement(421067..425518) 1 NC_001143.7 Ufd4p; Ubiquitin-protein ligase (E3) that interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins 425518 UFD4 853859 UFD4 Saccharomyces cerevisiae Ubiquitin-protein ligase (E3) that interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins NP_012915.1 421067 R 4932 CDS NP_012916.1 6322843 853860 425885..426595 1 NC_001143.7 Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus; Mrt4p 426595 MRT4 853860 MRT4 Saccharomyces cerevisiae Mrt4p NP_012916.1 425885 D 4932 CDS NP_012917.1 6322844 853861 complement(426938..428194) 1 NC_001143.7 Lac1p; Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p 428194 LAC1 853861 LAC1 Saccharomyces cerevisiae Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p NP_012917.1 426938 R 4932 CDS NP_012918.1 6322845 853862 428945..429751 1 NC_001143.7 Cap1p; Alpha subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches 429751 CAP1 853862 CAP1 Saccharomyces cerevisiae Alpha subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches NP_012918.1 428945 D 4932 CDS NP_012919.1 6322846 853863 complement(join(429841..430098,430240..430275)) 1 NC_001143.7 Sft1p; Intra-Golgi v-SNARE, required for transport of proteins between an early and a later Golgi compartment 430275 SFT1 853863 SFT1 Saccharomyces cerevisiae Intra-Golgi v-SNARE, required for transport of proteins between an early and a later Golgi compartment NP_012919.1 429841 R 4932 CDS NP_012920.1 6322847 853864 join(431549..431677,432076..432363) 1 NC_001143.7 Rpl14ap; N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl14Bp and has similarity to rat L14 ribosomal protein; rpl14a csh5 double null mutant exhibits synthetic slow growth 432363 RPL14A 853864 RPL14A Saccharomyces cerevisiae N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl14Bp and has similarity to rat L14 ribosomal protein; rpl14a csh5 double null mutant exhibits synthetic slow growth NP_012920.1 431549 D 4932 CDS NP_012921.1 6322848 853865 complement(432736..434520) 1 NC_001143.7 Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit; Bye1p 434520 BYE1 853865 BYE1 Saccharomyces cerevisiae Bye1p NP_012921.1 432736 R 4932 CDS NP_012922.1 6322849 853866 435223..436428 1 NC_001143.7 Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance; Aur1p 436428 AUR1 853866 AUR1 Saccharomyces cerevisiae Aur1p NP_012922.1 435223 D 4932 CDS NP_012923.1 6322850 853867 complement(436740..437135) 1 NC_001143.7 Mrp17p; Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator 437135 MRP17 853867 MRP17 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator NP_012923.1 436740 R 4932 CDS NP_012924.2 9755336 853868 join(437421..437480,437549..438187) 1 NC_001143.7 Did4p; Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis 438187 DID4 853868 DID4 Saccharomyces cerevisiae Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis NP_012924.2 437421 D 4932 CDS NP_012925.1 6322852 853869 complement(438420..439028) 1 NC_001143.7 Met14p; Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism 439028 MET14 853869 MET14 Saccharomyces cerevisiae Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism NP_012925.1 438420 R 4932 CDS NP_012926.1 6322853 853870 complement(440251..442365) 1 NC_001143.7 Vps1p; Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, late Golgi-retention of some proteins, regulating peroxisome biogenesis 442365 VPS1 853870 VPS1 Saccharomyces cerevisiae Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, late Golgi-retention of some proteins, regulating peroxisome biogenesis NP_012926.1 440251 R 4932 CDS NP_012927.1 6322854 853871 442875..444581 1 NC_001143.7 Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; Pap1p 444581 PAP1 853871 PAP1 Saccharomyces cerevisiae Pap1p NP_012927.1 442875 D 4932 CDS NP_012928.1 6322855 853872 445024..446370 1 NC_001143.7 Osh6p; Member of an oxysterol-binding protein family with overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery 446370 OSH6 853872 OSH6 Saccharomyces cerevisiae Member of an oxysterol-binding protein family with overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery NP_012928.1 445024 D 4932 CDS NP_012929.2 37362672 853873 complement(join(446442..447349,447454..447679)) 1 NC_001143.7 Non-essential protein of unknown function; Ecm9p 447679 ECM9 853873 ECM9 Saccharomyces cerevisiae Ecm9p NP_012929.2 446442 R 4932 CDS NP_012930.2 157285914 853874 complement(join(448164..449594,449664..449810)) 1 NC_001143.7 Ykr005cp; Putative protein of unknown function 449810 853874 YKR005C Saccharomyces cerevisiae Putative protein of unknown function NP_012930.2 448164 R 4932 CDS NP_012931.2 37362673 853875 complement(450066..450860) 1 NC_001143.7 Mrpl13p; Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation 450860 MRPL13 853875 MRPL13 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation NP_012931.2 450066 R 4932 CDS NP_012932.1 6322859 853876 451077..451631 1 NC_001143.7 Meh1p; Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification 451631 MEH1 853876 MEH1 Saccharomyces cerevisiae Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification NP_012932.1 451077 D 4932 CDS NP_012933.1 6322860 853877 451844..453721 1 NC_001143.7 Rsc4p; Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling 453721 RSC4 853877 RSC4 Saccharomyces cerevisiae Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling NP_012933.1 451844 D 4932 CDS NP_012934.1 6322861 853878 complement(453995..456697) 1 NC_001143.7 Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities; Fox2p 456697 FOX2 853878 FOX2 Saccharomyces cerevisiae Fox2p NP_012934.1 453995 R 4932 CDS NP_012935.1 6322862 853880 complement(458567..460882) 1 NC_001143.7 Tof2p; Nonessential mitochondrial protein of unknown function with sequence similarity to Net1p; identified as a topoisomerase I (Top1p) binding protein; displays synthetic genetic interactions with TOP1 and HPR1 460882 TOF2 853880 TOF2 Saccharomyces cerevisiae Nonessential mitochondrial protein of unknown function with sequence similarity to Net1p; identified as a topoisomerase I (Top1p) binding protein; displays synthetic genetic interactions with TOP1 and HPR1 NP_012935.1 458567 R 4932 CDS NP_012936.1 6322863 853881 complement(461278..462339) 1 NC_001143.7 Ykr011cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus 462339 853881 YKR011C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus NP_012936.1 461278 R 4932 CDS NP_012938.1 6322864 853882 463602..464591 1 NC_001143.7 Pry2p; Protein of unknown function, has similarity to Pry1p and Pry3p and to the plant PR-1 class of pathogen related proteins 464591 PRY2 853882 PRY2 Saccharomyces cerevisiae Protein of unknown function, has similarity to Pry1p and Pry3p and to the plant PR-1 class of pathogen related proteins NP_012938.1 463602 D 4932 CDS NP_012939.1 6322866 853884 complement(465010..465714) 1 NC_001143.7 Ypt52p; GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis 465714 YPT52 853884 YPT52 Saccharomyces cerevisiae GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis NP_012939.1 465010 R 4932 CDS NP_012940.1 6322867 853885 complement(466604..468310) 1 NC_001143.7 Ykr015cp; Putative protein of unknown function 468310 853885 YKR015C Saccharomyces cerevisiae Putative protein of unknown function NP_012940.1 466604 R 4932 CDS NP_012941.1 6322868 853886 469360..470982 1 NC_001143.7 Protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss and severe growth defect in minimal glycerol media; Aim28p 470982 AIM28 853886 AIM28 Saccharomyces cerevisiae Aim28p NP_012941.1 469360 D 4932 CDS NP_012942.1 6322869 853887 complement(471337..472992) 1 NC_001143.7 Ykr017cp; Putative protein of unknown function; contains a RING finger motif 472992 853887 YKR017C Saccharomyces cerevisiae Putative protein of unknown function; contains a RING finger motif NP_012942.1 471337 R 4932 CDS NP_012943.1 6322870 853888 complement(473366..475543) 1 NC_001143.7 Ykr018cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus 475543 853888 YKR018C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus NP_012943.1 473366 R 4932 CDS NP_012944.1 6322871 853889 complement(475859..477706) 1 NC_001143.7 Protein involved in regulation of phosphatidylinositol 4,5-bisphosphate concentrations; Irs4p and Tax4p bind and activate the phosphatase Inp51p; mutation confers an increase in rDNA silencing; Irs4p 477706 IRS4 853889 IRS4 Saccharomyces cerevisiae Irs4p NP_012944.1 475859 R 4932 CDS NP_012945.1 6322872 853890 477981..478475 1 NC_001143.7 Vps51p; Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p 478475 VPS51 853890 VPS51 Saccharomyces cerevisiae Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p NP_012945.1 477981 D 4932 CDS NP_012946.1 6322873 853891 478877..481624 1 NC_001143.7 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; Aly1p 481624 ALY1 853891 ALY1 Saccharomyces cerevisiae Aly1p NP_012946.1 478877 D 4932 CDS NP_012947.1 6322874 853892 complement(481814..482782) 1 NC_001143.7 Ntr2p; Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly 482782 NTR2 853892 NTR2 Saccharomyces cerevisiae Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly NP_012947.1 481814 R 4932 CDS NP_012948.1 6322875 853893 483062..484654 1 NC_001143.7 Ykr023wp; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 484654 853893 YKR023W Saccharomyces cerevisiae Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_012948.1 483062 D 4932 CDS NP_012949.1 6322876 853894 complement(484787..487015) 1 NC_001143.7 Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis; Dbp7p 487015 DBP7 853894 DBP7 Saccharomyces cerevisiae Dbp7p NP_012949.1 484787 R 4932 CDS NP_012950.1 6322877 853895 487413..488261 1 NC_001143.7 Rpc37p; RNA polymerase III subunit C37 488261 RPC37 853895 RPC37 Saccharomyces cerevisiae RNA polymerase III subunit C37 NP_012950.1 487413 D 4932 CDS NP_012951.1 6322878 853896 complement(488381..489298) 1 NC_001143.7 Gcn3p; Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression 489298 GCN3 853896 GCN3 Saccharomyces cerevisiae Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression NP_012951.1 488381 R 4932 CDS NP_012952.1 6322879 853898 491007..493304 1 NC_001143.7 Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; Bch2p 493304 BCH2 853898 BCH2 Saccharomyces cerevisiae Bch2p NP_012952.1 491007 D 4932 CDS NP_012953.1 6322880 853899 493900..497196 1 NC_001143.7 Sap190p; Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p 497196 SAP190 853899 SAP190 Saccharomyces cerevisiae Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p NP_012953.1 493900 D 4932 CDS NP_012954.1 6322881 853900 complement(497220..499475) 1 NC_001143.7 Set3p; Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains 499475 SET3 853900 SET3 Saccharomyces cerevisiae Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains NP_012954.1 497220 R 4932 CDS NP_012955.1 6322882 853901 499924..500745 1 NC_001143.7 Golgi membrane protein of unknown function, interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting; Gmh1p 500745 GMH1 853901 GMH1 Saccharomyces cerevisiae Gmh1p NP_012955.1 499924 D 4932 CDS NP_012956.1 6322883 853902 complement(500986..506037) 1 NC_001143.7 Spo14p; Phospholipase D, catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis 506037 SPO14 853902 SPO14 Saccharomyces cerevisiae Phospholipase D, catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis NP_012956.1 500986 R 4932 CDS NP_012959.1 6322885 853904 506540..507349 1 NC_001143.7 Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Deh1p; Dal80p 507349 DAL80 853904 DAL80 Saccharomyces cerevisiae Dal80p NP_012959.1 506540 D 4932 CDS NP_012961.1 6322887 853906 507581..508195 1 NC_001143.7 Did2p; Class E protein of the vacuolar protein-sorting (Vps) pathway, associates reversibly with the late endosome, has human ortholog that may be altered in breast tumors 508195 DID2 853906 DID2 Saccharomyces cerevisiae Class E protein of the vacuolar protein-sorting (Vps) pathway, associates reversibly with the late endosome, has human ortholog that may be altered in breast tumors NP_012961.1 507581 D 4932 CDS NP_012962.2 99030928 853908 complement(508344..510275) 1 NC_001143.7 WD40 repeat-containing protein associated with the CCR4-NOT complex, interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission; Caf4p 510275 CAF4 853908 CAF4 Saccharomyces cerevisiae Caf4p NP_012962.2 508344 R 4932 CDS NP_012963.1 6322890 853909 complement(510552..511439) 1 NC_001143.7 Spc34p; Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body 511439 SPC34 853909 SPC34 Saccharomyces cerevisiae Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body NP_012963.1 510552 R 4932 CDS NP_012964.2 37362674 853910 complement(511641..512801) 1 NC_001143.7 Putative glycoprotease proposed to be in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex; Kae1p 512801 KAE1 853910 KAE1 Saccharomyces cerevisiae Kae1p NP_012964.2 511641 R 4932 CDS NP_012965.1 6322892 853912 514705..516513 1 NC_001143.7 General amino acid permease; localization to the plasma membrane is regulated by nitrogen source; Gap1p 516513 GAP1 853912 GAP1 Saccharomyces cerevisiae Gap1p NP_012965.1 514705 D 4932 CDS NP_012967.1 6322893 853914 517840..518592 1 NC_001143.7 Ykr041wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus 518592 853914 YKR041W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus NP_012967.1 517840 D 4932 CDS NP_012968.2 81358765 853916 519169..520266 1 NC_001143.7 Uth1p; Mitochondrial outer membrane and cell wall localized SUN family member required for mitochondrial autophagy; involved in the oxidative stress response, life span during starvation, mitochondrial biogenesis, and cell death 520266 UTH1 853916 UTH1 Saccharomyces cerevisiae Mitochondrial outer membrane and cell wall localized SUN family member required for mitochondrial autophagy; involved in the oxidative stress response, life span during starvation, mitochondrial biogenesis, and cell death NP_012968.2 519169 D 4932 CDS NP_012969.1 6322896 853917 complement(520539..521354) 1 NC_001143.7 Ykr043cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus 521354 853917 YKR043C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus NP_012969.1 520539 R 4932 CDS NP_012970.1 6322897 853918 521657..522988 1 NC_001143.7 Uip5p; Protein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates 522988 UIP5 853918 UIP5 Saccharomyces cerevisiae Protein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates NP_012970.1 521657 D 4932 CDS NP_012971.2 37362675 853919 complement(523060..523611) 1 NC_001143.7 Ykr045cp; Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm 523611 853919 YKR045C Saccharomyces cerevisiae Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm NP_012971.2 523060 R 4932 CDS NP_012972.1 6322899 853920 complement(523865..524716) 1 NC_001143.7 Protein of unknown function that co-purifies with lipid particles; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange; Pet10p 524716 PET10 853920 PET10 Saccharomyces cerevisiae Pet10p NP_012972.1 523865 R 4932 CDS NP_012974.1 6322901 853922 complement(525029..526282) 1 NC_001143.7 Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus; Nap1p 526282 NAP1 853922 NAP1 Saccharomyces cerevisiae Nap1p NP_012974.1 525029 R 4932 CDS NP_012975.1 6322902 853923 complement(526472..526873) 1 NC_001143.7 Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Fmp46p 526873 FMP46 853923 FMP46 Saccharomyces cerevisiae Fmp46p NP_012975.1 526472 R 4932 CDS NP_012976.1 6322903 853924 527457..530126 1 NC_001143.7 Trk2p; Component of the Trk1p-Trk2p potassium transport system 530126 TRK2 853924 TRK2 Saccharomyces cerevisiae Component of the Trk1p-Trk2p potassium transport system NP_012976.1 527457 D 4932 CDS NP_012977.1 6322904 853925 530588..531844 1 NC_001143.7 Ykr051wp; Putative protein of unknown function 531844 853925 YKR051W Saccharomyces cerevisiae Putative protein of unknown function NP_012977.1 530588 D 4932 CDS NP_012978.1 6322905 853926 complement(532192..533106) 1 NC_001143.7 Mrs4p; Mitochondrial iron transporter of the mitochondrial carrier family (MCF), very similar to and functionally redundant with Mrs3p; functions under low-iron conditions; may transport other cations in addition to iron 533106 MRS4 853926 MRS4 Saccharomyces cerevisiae Mitochondrial iron transporter of the mitochondrial carrier family (MCF), very similar to and functionally redundant with Mrs3p; functions under low-iron conditions; may transport other cations in addition to iron NP_012978.1 532192 R 4932 CDS NP_012979.1 6322906 853927 complement(533709..534923) 1 NC_001143.7 Ysr3p; Dihydrosphingosine 1-phosphate phosphatase, membrane protein involved in sphingolipid metabolism; has similarity to Lcb3p 534923 YSR3 853927 YSR3 Saccharomyces cerevisiae Dihydrosphingosine 1-phosphate phosphatase, membrane protein involved in sphingolipid metabolism; has similarity to Lcb3p NP_012979.1 533709 R 4932 CDS NP_012980.1 6322907 853928 complement(535289..547567) 1 NC_001143.7 Dyn1p; Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p 547567 DYN1 853928 DYN1 Saccharomyces cerevisiae Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p NP_012980.1 535289 R 4932 CDS NP_012981.1 6322908 853929 547858..548733 1 NC_001143.7 Rho4p; Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity 548733 RHO4 853929 RHO4 Saccharomyces cerevisiae Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity NP_012981.1 547858 D 4932 CDS NP_012982.2 42759862 853930 549090..551009 1 NC_001143.7 tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair; Trm2p 551009 TRM2 853930 TRM2 Saccharomyces cerevisiae Trm2p NP_012982.2 549090 D 4932 CDS NP_012983.1 6322910 853931 join(551299..551322,551645..551884) 1 NC_001143.7 Rps21ap; Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Bp and has similarity to rat S21 ribosomal protein 551884 RPS21A 853931 RPS21A Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Bp and has similarity to rat S21 ribosomal protein NP_012983.1 551299 D 4932 CDS NP_012984.2 83578103 853932 552412..554262 1 NC_001143.7 Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; Glg1p 554262 GLG1 853932 GLG1 Saccharomyces cerevisiae Glg1p NP_012984.2 552412 D 4932 CDS NP_012985.1 6322912 853933 554629..555816 1 NC_001143.7 Translation initiation factor eIF4A, identical to Tif2p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; Tif1p 555816 TIF1 853933 TIF1 Saccharomyces cerevisiae Tif1p NP_012985.1 554629 D 4932 CDS NP_012986.1 6322913 853934 556160..556984 1 NC_001143.7 Utp30p; Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data 556984 UTP30 853934 UTP30 Saccharomyces cerevisiae Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data NP_012986.1 556160 D 4932 CDS NP_012987.1 6322914 853935 557319..558596 1 NC_001143.7 Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Ktr2p 558596 KTR2 853935 KTR2 Saccharomyces cerevisiae Ktr2p NP_012987.1 557319 D 4932 CDS NP_012988.1 6322915 853936 559308..560294 1 NC_001143.7 Tfa2p; TFIIE small subunit, involved in RNA polymerase II transcription initiation 560294 TFA2 853936 TFA2 Saccharomyces cerevisiae TFIIE small subunit, involved in RNA polymerase II transcription initiation NP_012988.1 559308 D 4932 CDS NP_012989.1 6322916 853937 complement(560431..561939) 1 NC_001143.7 Las1p; Essential nuclear protein possibly involved in bud formation and morphogenesis; mutants require the SSD1-v allele for viability 561939 LAS1 853937 LAS1 Saccharomyces cerevisiae Essential nuclear protein possibly involved in bud formation and morphogenesis; mutants require the SSD1-v allele for viability NP_012989.1 560431 R 4932 CDS NP_012990.1 6322917 853938 562189..564780 1 NC_001143.7 Zinc cluster protein; regulates transcription in response to oleate levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Oaf3p 564780 OAF3 853938 OAF3 Saccharomyces cerevisiae Oaf3p NP_012990.1 562189 D 4932 CDS NP_012991.1 6322918 853939 complement(564941..565534) 1 NC_001143.7 Presequence translocase-associated motor subunit, required for stable complex formation between cochaperones Pam16p and Pam18p, promotes association of Pam16p-Pam18p with the presequence translocase; Pam17p 565534 PAM17 853939 PAM17 Saccharomyces cerevisiae Pam17p NP_012991.1 564941 R 4932 CDS NP_012992.1 6322919 853940 complement(565755..566840) 1 NC_001143.7 Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress; Ccp1p 566840 CCP1 853940 CCP1 Saccharomyces cerevisiae Ccp1p NP_012992.1 565755 R 4932 CDS NP_012993.1 6322920 853941 567560..569791 1 NC_001143.7 Gpt2p; Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis 569791 GPT2 853941 GPT2 Saccharomyces cerevisiae Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis NP_012993.1 567560 D 4932 CDS NP_012994.1 6322921 853942 complement(569970..570551) 1 NC_001143.7 Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles; component of the TRAPP (transport protein particle) complex; Bet3p 570551 BET3 853942 BET3 Saccharomyces cerevisiae Bet3p NP_012994.1 569970 R 4932 CDS NP_012995.1 6322922 853943 571254..573035 1 NC_001143.7 S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis; Met1p 573035 MET1 853943 MET1 Saccharomyces cerevisiae Met1p NP_012995.1 571254 D 4932 CDS NP_012996.1 6322923 853944 573216..574274 1 NC_001143.7 Ykr070wp; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 574274 853944 YKR070W Saccharomyces cerevisiae Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_012996.1 573216 D 4932 CDS NP_012997.1 6322924 853945 complement(574576..575622) 1 NC_001143.7 Protein of unknown function; mutation displays synthetic lethal interaction with the pol3-13 allele of CDC2; Dre2p 575622 DRE2 853945 DRE2 Saccharomyces cerevisiae Dre2p NP_012997.1 574576 R 4932 CDS NP_012998.1 6322925 853946 complement(576077..577765) 1 NC_001143.7 Sis2p; Negative regulatory subunit of the protein phosphatase 1 Ppz1p; involved in ion homeostasis and cell cycle progression 577765 SIS2 853946 SIS2 Saccharomyces cerevisiae Negative regulatory subunit of the protein phosphatase 1 Ppz1p; involved in ion homeostasis and cell cycle progression NP_012998.1 576077 R 4932 CDS NP_013000.1 6322927 853949 578851..579318 1 NC_001143.7 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; null mutant displays increased frequency of mitochondrial genome loss (petite formation); Aim29p 579318 AIM29 853949 AIM29 Saccharomyces cerevisiae Aim29p NP_013000.1 578851 D 4932 CDS NP_013001.1 6322928 853950 complement(579469..580392) 1 NC_001143.7 Ykr075cp; Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS 580392 853950 YKR075C Saccharomyces cerevisiae Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS NP_013001.1 579469 R 4932 CDS NP_013002.1 6322929 853951 581925..583037 1 NC_001143.7 Omega class glutathione transferase; not essential; similar to Ygr154cp; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; Ecm4p 583037 ECM4 853951 ECM4 Saccharomyces cerevisiae Ecm4p NP_013002.1 581925 D 4932 CDS NP_013003.1 6322930 853952 583295..584386 1 NC_001143.7 Putative transcriptional activator, that interacts with G1-specific transcription factor, MBF and G1-specific promoters; ortholog of Msa2p, an MBF and SBF activator that regulates G1-specific transcription and cell cycle initiation; Msa2p 584386 MSA2 853952 MSA2 Saccharomyces cerevisiae Msa2p NP_013003.1 583295 D 4932 CDS NP_013004.1 6322931 853953 584594..586351 1 NC_001143.7 Ykr078wp; Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P) 586351 853953 YKR078W Saccharomyces cerevisiae Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P) NP_013004.1 584594 D 4932 CDS NP_013005.1 6322932 853954 complement(586431..588947) 1 NC_001143.7 tRNase Z, involved in RNA processing, has two putative nucleotide triphosphate-binding motifs (P-loop) and a conserved histidine motif, homolog of the human candidate prostate cancer susceptibility gene ELAC2; Trz1p 588947 TRZ1 853954 TRZ1 Saccharomyces cerevisiae Trz1p NP_013005.1 586431 R 4932 CDS NP_013006.1 6322933 853955 590037..590999 1 NC_001143.7 NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline; Mtd1p 590999 MTD1 853955 MTD1 Saccharomyces cerevisiae Mtd1p NP_013006.1 590037 D 4932 CDS NP_013007.1 6322934 853956 complement(591148..592182) 1 NC_001143.7 Rpf2p; Essential protein involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles 592182 RPF2 853956 RPF2 Saccharomyces cerevisiae Essential protein involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles NP_013007.1 591148 R 4932 CDS NP_013008.1 6322935 853957 592467..595940 1 NC_001143.7 Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), localizes to both sides of the NPC, required to establish a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; Nup133p 595940 NUP133 853957 NUP133 Saccharomyces cerevisiae Nup133p NP_013008.1 592467 D 4932 CDS NP_013009.1 6322936 853958 complement(596063..596464) 1 NC_001143.7 Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis; Dad2p 596464 DAD2 853958 DAD2 Saccharomyces cerevisiae Dad2p NP_013009.1 596063 R 4932 CDS NP_013010.1 6322937 853959 complement(596697..598532) 1 NC_001143.7 Hbs1p; GTP binding protein with sequence similarity to the elongation factor class of G proteins, EF-1alpha and Sup35p; associates with Dom34p, and shares a similar genetic relationship with genes that encode ribosomal protein components 598532 HBS1 853959 HBS1 Saccharomyces cerevisiae GTP binding protein with sequence similarity to the elongation factor class of G proteins, EF-1alpha and Sup35p; associates with Dom34p, and shares a similar genetic relationship with genes that encode ribosomal protein components NP_013010.1 596697 R 4932 CDS NP_013011.1 6322938 853960 complement(598736..599323) 1 NC_001143.7 Mrpl20p; Mitochondrial ribosomal protein of the large subunit 599323 MRPL20 853960 MRPL20 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit NP_013011.1 598736 R 4932 CDS NP_013012.1 6322939 853961 599499..602714 1 NC_001143.7 RNA helicase in the DEAH-box family involved in the second catalytic step of splicing, exhibits ATP-dependent RNA unwinding activity; Prp16p 602714 PRP16 853961 PRP16 Saccharomyces cerevisiae Prp16p NP_013012.1 599499 D 4932 CDS NP_013013.2 50593425 853962 complement(602837..603874) 1 NC_001143.7 Oma1p; Metalloendopeptidase of the mitochondrial inner membrane, involved in turnover of membrane-embedded proteins; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes 603874 OMA1 853962 OMA1 Saccharomyces cerevisiae Metalloendopeptidase of the mitochondrial inner membrane, involved in turnover of membrane-embedded proteins; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes NP_013013.2 602837 R 4932 CDS NP_013014.1 6322941 853963 complement(604047..605060) 1 NC_001143.7 Tvp38p; Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 605060 TVP38 853963 TVP38 Saccharomyces cerevisiae Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern NP_013014.1 604047 R 4932 CDS NP_013015.1 6322942 853964 complement(605275..608007) 1 NC_001143.7 Triacylglycerol lipase involved in triacylglycerol mobilization and degradation; found in lipid particles; potential Cdc28p substrate; Tgl4p 608007 TGL4 853964 TGL4 Saccharomyces cerevisiae Tgl4p NP_013015.1 605275 R 4932 CDS NP_013016.1 6322943 853965 608588..610708 1 NC_001143.7 Pxl1p; LIM domain-containing protein that localizes to sites of polarized growth, required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; has similarity to metazoan paxillin 610708 PXL1 853965 PXL1 Saccharomyces cerevisiae LIM domain-containing protein that localizes to sites of polarized growth, required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; has similarity to metazoan paxillin NP_013016.1 608588 D 4932 CDS NP_013017.2 50593426 853966 611167..611907 1 NC_001143.7 Srl3p; Cytoplasmic protein that, when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate 611907 SRL3 853966 SRL3 Saccharomyces cerevisiae Cytoplasmic protein that, when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate NP_013017.2 611167 D 4932 CDS NP_013018.1 6322945 853967 complement(612307..613527) 1 NC_001143.7 Srp40p; Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140 613527 SRP40 853967 SRP40 Saccharomyces cerevisiae Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140 NP_013018.1 612307 R 4932 CDS NP_013019.1 6322946 853968 615372..617177 1 NC_001143.7 Ptr2p; Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p 617177 PTR2 853968 PTR2 Saccharomyces cerevisiae Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p NP_013019.1 615372 D 4932 CDS NP_013020.1 6322947 853969 complement(join(617638..618016,618385..618392)) 1 NC_001143.7 Rpl40bp; Fusion protein, identical to Rpl40Ap, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes 618392 RPL40B 853969 RPL40B Saccharomyces cerevisiae Fusion protein, identical to Rpl40Ap, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes NP_013020.1 617638 R 4932 CDS NP_013021.1 6322948 853970 619447..625074 1 NC_001143.7 Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs; Mlp1p 625074 MLP1 853970 MLP1 Saccharomyces cerevisiae Mlp1p NP_013021.1 619447 D 4932 CDS NP_878113.2 41629697 1500489 join(625506..625543,625619..625847) 1 NC_001143.7 Proposed transcription factor involved in the expression of genes regulated by alpha-factor and galactose; component of the EKC/KEOPS protein complex with Kae1p, Gon7p, Bud32p, and Cgi121p; related to human cancer-testis antigens; Pcc1p 625847 PCC1 1500489 PCC1 Saccharomyces cerevisiae Pcc1p NP_878113.2 625506 D 4932 CDS NP_013022.1 6322949 853971 626435..630022 1 NC_001143.7 Ykr096wp; Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; predicted to contain a PINc (PilT N terminus) domain 630022 853971 YKR096W Saccharomyces cerevisiae Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; predicted to contain a PINc (PilT N terminus) domain NP_013022.1 626435 D 4932 CDS NP_013023.1 6322950 853972 630790..632439 1 NC_001143.7 Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol; Pck1p 632439 PCK1 853972 PCK1 Saccharomyces cerevisiae Pck1p NP_013023.1 630790 D 4932 CDS NP_013024.1 6322951 853973 complement(632664..634817) 1 NC_001143.7 Ubp11p; Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins 634817 UBP11 853973 UBP11 Saccharomyces cerevisiae Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins NP_013024.1 632664 R 4932 CDS NP_013025.1 6322952 853974 635489..637924 1 NC_001143.7 Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes; Bas1p 637924 BAS1 853974 BAS1 Saccharomyces cerevisiae Bas1p NP_013025.1 635489 D 4932 CDS NP_013026.2 42759863 853975 complement(638539..639606) 1 NC_001143.7 Transmembrane protein with a role in cell wall polymer composition; localizes on the inner surface of the plasma membrane at the bud and in the daughter cell; Skg1p 639606 SKG1 853975 SKG1 Saccharomyces cerevisiae Skg1p NP_013026.2 638539 R 4932 CDS NP_013027.1 6322954 853976 640106..642142 1 NC_001143.7 Sir1p; Protein involved in repression of transcription at the silent mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin 642142 SIR1 853976 SIR1 Saccharomyces cerevisiae Protein involved in repression of transcription at the silent mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin NP_013027.1 640106 D 4932 CDS NP_013028.1 6322955 853977 645994..649503 1 NC_001143.7 Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation; Flo10p 649503 FLO10 853977 FLO10 Saccharomyces cerevisiae Flo10p NP_013028.1 645994 D 4932 CDS NP_013029.1 6322956 853978 652718..656374 1 NC_001143.7 Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds.; Nft1p 656374 NFT1 853978 NFT1 Saccharomyces cerevisiae Nft1p NP_013029.1 652718 D 4932 CDS NP_013030.1 6322957 853979 656474..657394 1 NC_001143.7 Ykr104wp; Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds 657394 853979 YKR104W Saccharomyces cerevisiae Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds NP_013030.1 656474 D 4932 CDS NP_013031.1 6322958 853980 complement(658354..660102) 1 NC_001143.7 Ykr105cp; Putative transporter of the Major Facilitator Superfamily (MFS) 660102 853980 YKR105C Saccharomyces cerevisiae Putative transporter of the Major Facilitator Superfamily (MFS) NP_013031.1 658354 R 4932 CDS NP_013032.1 6322959 853981 661080..662927 1 NC_001143.7 Ykr106wp; Protein of unconfirmed function; displays a topology characteristic of the Major Facilitators Superfamily of membrane proteins; coding sequence 98% identical to that of YCL073C 662927 853981 YKR106W Saccharomyces cerevisiae Protein of unconfirmed function; displays a topology characteristic of the Major Facilitators Superfamily of membrane proteins; coding sequence 98% identical to that of YCL073C NP_013032.1 661080 D 4932 CDS NP_013033.1 6322961 850659 complement(join(585..3915,4015..4301)) 1 NC_001144.4 Yll067cp; Putative protein of unknown function with similarity to helicases 4301 850659 YLL067C Saccharomyces cerevisiae Putative protein of unknown function with similarity to helicases NP_013033.1 585 R 4932 CDS NP_878115.1 33438827 1466404 5605..5775 1 NC_001144.4 Yll066w-bp; Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data 5775 1466404 YLL066W-B Saccharomyces cerevisiae Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data NP_878115.1 5605 D 4932 CDS NP_013034.1 6322962 850660 complement(join(6120..9450,9550..9836)) 1 NC_001144.4 Yll066cp; Putative protein of unknown function with similarity to helicases; YLL066C is not an essential gene 9836 850660 YLL066C Saccharomyces cerevisiae Putative protein of unknown function with similarity to helicases; YLL066C is not an essential gene NP_013034.1 6120 R 4932 CDS NP_013036.1 6322964 850662 complement(13083..13445) 1 NC_001144.4 Pau18p 13445 PAU18 850662 PAU18 Saccharomyces cerevisiae Pau18p NP_013036.1 13083 R 4932 CDS NP_013037.1 6322965 850663 complement(14648..16072) 1 NC_001144.4 Ayt1p; Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis 16072 AYT1 850663 AYT1 Saccharomyces cerevisiae Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis NP_013037.1 14648 R 4932 CDS NP_013038.1 6322966 850664 complement(16639..17613) 1 NC_001144.4 S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio; Mht1p 17613 MHT1 850664 MHT1 Saccharomyces cerevisiae Mht1p NP_013038.1 16639 R 4932 CDS NP_013039.1 6322967 850665 17956..19707 1 NC_001144.4 Mmp1p; High-affinity S-methylmethionine permease, required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p 19707 MMP1 850665 MMP1 Saccharomyces cerevisiae High-affinity S-methylmethionine permease, required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p NP_013039.1 17956 D 4932 CDS NP_013040.1 6322968 850666 complement(21138..21839) 1 NC_001144.4 Gtt2p; Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p 21839 GTT2 850666 GTT2 Saccharomyces cerevisiae Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p NP_013040.1 21138 R 4932 CDS NP_013042.1 6322970 850668 23569..25296 1 NC_001144.4 Yll058wp; Putative protein of unknown function with similarity to Str2p, which is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene 25296 850668 YLL058W Saccharomyces cerevisiae Putative protein of unknown function with similarity to Str2p, which is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene NP_013042.1 23569 D 4932 CDS NP_013043.1 6322971 850669 complement(25756..26994) 1 NC_001144.4 Jlp1p; Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein) 26994 JLP1 850669 JLP1 Saccharomyces cerevisiae Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein) NP_013043.1 25756 R 4932 CDS NP_013044.1 6322972 850670 complement(27409..28305) 1 NC_001144.4 Yll056cp; Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in pleiotropic drug resistance (PDR) phenomenon; YLL056C is not an essential gene 28305 850670 YLL056C Saccharomyces cerevisiae Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in pleiotropic drug resistance (PDR) phenomenon; YLL056C is not an essential gene NP_013044.1 27409 R 4932 CDS NP_013045.1 6322973 850671 30109..31704 1 NC_001144.4 Yct1p; High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene 31704 YCT1 850671 YCT1 Saccharomyces cerevisiae High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene NP_013045.1 30109 D 4932 CDS NP_013046.1 6322974 850672 complement(32894..35203) 1 NC_001144.4 Yll054cp; Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene 35203 850672 YLL054C Saccharomyces cerevisiae Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene NP_013046.1 32894 R 4932 CDS NP_013047.1 6322975 850673 complement(35502..35960) 1 NC_001144.4 Yll053cp; Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin 35960 850673 YLL053C Saccharomyces cerevisiae Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin NP_013047.1 35502 R 4932 CDS NP_013048.1 6322976 850674 complement(35911..36360) 1 NC_001144.4 Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains; Aqy2p 36360 AQY2 850674 AQY2 Saccharomyces cerevisiae Aqy2p NP_013048.1 35911 R 4932 CDS NP_013049.1 6322977 850675 complement(37332..39470) 1 NC_001144.4 Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; Fre6p 39470 FRE6 850675 FRE6 Saccharomyces cerevisiae Fre6p NP_013049.1 37332 R 4932 CDS NP_013050.1 6322978 850676 complement(join(39803..40220,40400..40413)) 1 NC_001144.4 Cofilin, promotes actin filament depolarization in a pH-dependent manner; binds both actin monomers and filaments and severs filaments , thought to be regulated by phosphorylation at SER4, ubiquitous and essential in eukaryotes; Cof1p 40413 COF1 850676 COF1 Saccharomyces cerevisiae Cof1p NP_013050.1 39803 R 4932 CDS NP_013051.1 6322979 850677 40665..41204 1 NC_001144.4 Protein of unknown function; null mutant shows a reduced affinity for the alcian blue dye suggesting a decreased net negative charge of the cell surface; Ldb18p 41204 LDB18 850677 LDB18 Saccharomyces cerevisiae Ldb18p NP_013051.1 40665 D 4932 CDS NP_013052.1 6322980 850678 complement(41279..46264) 1 NC_001144.4 Ybt1p; Transporter of the ATP-binding cassette (ABC) family involved in bile acid transport; similar to mammalian bile transporters 46264 YBT1 850678 YBT1 Saccharomyces cerevisiae Transporter of the ATP-binding cassette (ABC) family involved in bile acid transport; similar to mammalian bile transporters NP_013052.1 41279 R 4932 CDS NP_013054.1 6322982 850680 complement(46713..47462) 1 NC_001144.4 Rnp1p; Ribonucleoprotein that contains two RNA recognition motifs (RRM) 47462 RNP1 850680 RNP1 Saccharomyces cerevisiae Ribonucleoprotein that contains two RNA recognition motifs (RRM) NP_013054.1 46713 R 4932 CDS NP_013055.1 6322984 850682 complement(47858..48628) 1 NC_001144.4 Rpl8bp; Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits 48628 RPL8B 850682 RPL8B Saccharomyces cerevisiae Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits NP_013055.1 47858 R 4932 CDS NP_013057.1 6322985 850683 49937..51946 1 NC_001144.4 Plasma membrane glycerol channel, member of the major intrinsic protein (MIP) family of channel proteins; involved in efflux of glycerol and in uptake of the trivalent metalloids arsenite and antimonite; Fps1p 51946 FPS1 850683 FPS1 Saccharomyces cerevisiae Fps1p NP_013057.1 49937 D 4932 CDS NP_013058.1 6322986 850684 complement(52086..52589) 1 NC_001144.4 E2-like conjugating enzyme that mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy; Atg10p 52589 ATG10 850684 ATG10 Saccharomyces cerevisiae Atg10p NP_013058.1 52086 R 4932 CDS NP_013059.1 6322987 850685 complement(53130..53930) 1 NC_001144.4 Sdh2p; Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone 53930 SDH2 850685 SDH2 Saccharomyces cerevisiae Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone NP_013059.1 53130 R 4932 CDS NP_013060.1 6322988 850619 complement(54210..63644) 1 NC_001144.4 Vps13p; Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; homologous to human COH1; involved in sporulation, vacuolar protein sorting and protein-Golgi retention 63644 VPS13 850619 VPS13 Saccharomyces cerevisiae Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; homologous to human COH1; involved in sporulation, vacuolar protein sorting and protein-Golgi retention NP_013060.1 54210 R 4932 CDS NP_013061.1 6322989 850620 complement(64061..65206) 1 NC_001144.4 Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; Ubi4p 65206 UBI4 850620 UBI4 Saccharomyces cerevisiae Ubi4p NP_013061.1 64061 R 4932 CDS NP_013062.1 6322990 850621 complement(65774..66517) 1 NC_001144.4 Protein of unknown function, contains an N-terminal epsin-like domain; Ent4p 66517 ENT4 850621 ENT4 Saccharomyces cerevisiae Ent4p NP_013062.1 65774 R 4932 CDS NP_013064.1 6322992 850623 complement(66744..68255) 1 NC_001144.4 Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases; Prp19p 68255 PRP19 850623 PRP19 Saccharomyces cerevisiae Prp19p NP_013064.1 66744 R 4932 CDS NP_013065.1 6322993 850624 68579..70477 1 NC_001144.4 Protein of unknown function, required for cell growth and possibly involved in rRNA processing; mRNA is cell cycle regulated; Grc3p 70477 GRC3 850624 GRC3 Saccharomyces cerevisiae Grc3p NP_013065.1 68579 D 4932 CDS NP_013066.1 6322994 850625 complement(70632..73145) 1 NC_001144.4 Rix7p; Putative ATPase of the AAA family, required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions 73145 RIX7 850625 RIX7 Saccharomyces cerevisiae Putative ATPase of the AAA family, required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions NP_013066.1 70632 R 4932 CDS NP_013067.1 6322995 850626 73408..74100 1 NC_001144.4 Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52 foci; Irc19p 74100 IRC19 850626 IRC19 Saccharomyces cerevisiae Irc19p NP_013067.1 73408 D 4932 CDS NP_013068.1 6322996 850627 complement(74269..76746) 1 NC_001144.4 Yll032cp; Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene 76746 850627 YLL032C Saccharomyces cerevisiae Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene NP_013068.1 74269 R 4932 CDS NP_013069.1 6322997 850628 complement(77151..80204) 1 NC_001144.4 Gpi13p; ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein 80204 GPI13 850628 GPI13 Saccharomyces cerevisiae ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein NP_013069.1 77151 R 4932 CDS NP_013071.1 6322999 850630 81460..83709 1 NC_001144.4 Rup2p; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL029W is not an essential gene but mutant is defective in spore formation 83709 RUP2 850630 RUP2 Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL029W is not an essential gene but mutant is defective in spore formation NP_013071.1 81460 D 4932 CDS NP_013072.1 6323000 850631 84803..86563 1 NC_001144.4 Tpo1p; Polyamine transporter that recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane 86563 TPO1 850631 TPO1 Saccharomyces cerevisiae Polyamine transporter that recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane NP_013072.1 84803 D 4932 CDS NP_013073.1 6323001 850632 87402..88154 1 NC_001144.4 Mitochondrial matrix protein involved in biogenesis of the iron-sulfur (Fe/S) cluster of Fe/S proteins, isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources; Isa1p 88154 ISA1 850632 ISA1 Saccharomyces cerevisiae Isa1p NP_013073.1 87402 D 4932 CDS NP_013074.1 6323002 850633 88622..91348 1 NC_001144.4 Hsp104p; Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation 91348 HSP104 850633 HSP104 Saccharomyces cerevisiae Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation NP_013074.1 88622 D 4932 CDS NP_013075.1 6323003 850635 94746..95120 1 NC_001144.4 Putative protein of unknown function; YLL025W is not an essential gene; Pau17p 95120 PAU17 850635 PAU17 Saccharomyces cerevisiae Pau17p NP_013075.1 94746 D 4932 CDS NP_013076.1 6323004 850636 complement(95565..97484) 1 NC_001144.4 Ssa2p; ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall 97484 SSA2 850636 SSA2 Saccharomyces cerevisiae ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall NP_013076.1 95565 R 4932 CDS NP_013077.1 6323005 850637 complement(97996..98835) 1 NC_001144.4 Yll023cp; Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum 98835 850637 YLL023C Saccharomyces cerevisiae Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum NP_013077.1 97996 R 4932 CDS NP_013078.1 6323006 850638 complement(99043..100200) 1 NC_001144.4 Non-essential component of the HAT-B histone acetyltransferase complex (Hat1p-Hat2p-Hif1p), localized to the nucleus; has a role in telomeric silencing; Hif1p 100200 HIF1 850638 HIF1 Saccharomyces cerevisiae Hif1p NP_013078.1 99043 R 4932 CDS NP_013079.1 6323007 850639 100946..105346 1 NC_001144.4 Spa2p; Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate 105346 SPA2 850639 SPA2 Saccharomyces cerevisiae Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate NP_013079.1 100946 D 4932 CDS NP_013081.1 6323009 850641 complement(105685..107898) 1 NC_001144.4 Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; Kns1p 107898 KNS1 850641 KNS1 Saccharomyces cerevisiae Kns1p NP_013081.1 105685 R 4932 CDS NP_013082.1 6323010 850642 complement(108675..108971) 1 NC_001144.4 Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase; Cox19p 108971 COX19 850642 COX19 Saccharomyces cerevisiae Cox19p NP_013082.1 108675 R 4932 CDS NP_013083.1 6323011 850643 complement(109901..111574) 1 NC_001144.4 Dps1p; Cytoplasmic aspartyl-tRNA synthetase, homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation 111574 DPS1 850643 DPS1 Saccharomyces cerevisiae Cytoplasmic aspartyl-tRNA synthetase, homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation NP_013083.1 109901 R 4932 CDS NP_013086.1 6323014 850645 116431..121110 1 NC_001144.4 Bpt1p; ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p 121110 BPT1 850645 BPT1 Saccharomyces cerevisiae ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p NP_013086.1 116431 D 4932 CDS NP_013087.1 6323015 850646 121321..121647 1 NC_001144.4 Yll014wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLL014W is not an essential gene 121647 850646 YLL014W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLL014W is not an essential gene NP_013087.1 121321 D 4932 CDS NP_013088.1 6323016 850647 complement(122074..124713) 1 NC_001144.4 Puf3p; Protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins 124713 PUF3 850647 PUF3 Saccharomyces cerevisiae Protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins NP_013088.1 122074 R 4932 CDS NP_013089.1 6323017 850648 125533..127254 1 NC_001144.4 Yeh1p; Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes 127254 YEH1 850648 YEH1 Saccharomyces cerevisiae Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes NP_013089.1 125533 D 4932 CDS NP_013090.1 6323018 850649 127522..128991 1 NC_001144.4 Sof1p; Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p 128991 SOF1 850649 SOF1 Saccharomyces cerevisiae Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p NP_013090.1 127522 D 4932 CDS NP_013091.1 6323019 850650 complement(129329..130612) 1 NC_001144.4 Psr1p; Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p 130612 PSR1 850650 PSR1 Saccharomyces cerevisiae Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p NP_013091.1 129329 R 4932 CDS NP_013092.1 6323020 850651 complement(131204..131413) 1 NC_001144.4 Cox17p; Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase 131413 COX17 850651 COX17 Saccharomyces cerevisiae Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase NP_013092.1 131204 R 4932 CDS NP_013093.1 6323021 850652 131728..133986 1 NC_001144.4 Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles; Drs1p 133986 DRS1 850652 DRS1 Saccharomyces cerevisiae Drs1p NP_013093.1 131728 D 4932 CDS NP_013094.1 6323022 850653 complement(134301..136298) 1 NC_001144.4 Yll007cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL007C is not an essential gene 136298 850653 YLL007C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL007C is not an essential gene NP_013094.1 134301 R 4932 CDS NP_878116.1 33438828 1466403 136344..136520 1 NC_001144.4 Yll006w-ap; Putative protein of unknown function; identified by fungal homology and RT-PCR 136520 1466403 YLL006W-A Saccharomyces cerevisiae Putative protein of unknown function; identified by fungal homology and RT-PCR NP_878116.1 136344 D 4932 CDS NP_013095.1 6323023 850654 136585..137865 1 NC_001144.4 Mmm1p; Mitochondrial outer membrane protein, component of the Mdm10-Mdm12-Mmm1 complex involved in import and assembly of outer membrane beta-barrel proteins 137865 MMM1 850654 MMM1 Saccharomyces cerevisiae Mitochondrial outer membrane protein, component of the Mdm10-Mdm12-Mmm1 complex involved in import and assembly of outer membrane beta-barrel proteins NP_013095.1 136585 D 4932 CDS NP_013096.1 6323024 850655 complement(137939..140545) 1 NC_001144.4 Spo75p; Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis 140545 SPO75 850655 SPO75 Saccharomyces cerevisiae Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis NP_013096.1 137939 R 4932 CDS NP_013097.1 6323025 850656 141072..142922 1 NC_001144.4 Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; Orc3p 142922 ORC3 850656 ORC3 Saccharomyces cerevisiae Orc3p NP_013097.1 141072 D 4932 CDS NP_013098.1 6323026 850657 143200..146040 1 NC_001144.4 Sfi1p; Centrin (Cdc31p)-binding protein required for spindle pole body (SPB) duplication, localizes to the half-bridge of the SPB, required for progression through G(2)-M transition, has similarity to Xenopus laevis XCAP-C 146040 SFI1 850657 SFI1 Saccharomyces cerevisiae Centrin (Cdc31p)-binding protein required for spindle pole body (SPB) duplication, localizes to the half-bridge of the SPB, required for progression through G(2)-M transition, has similarity to Xenopus laevis XCAP-C NP_013098.1 143200 D 4932 CDS NP_013099.1 6323027 850658 146290..147600 1 NC_001144.4 Rtt109p; Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase, acetylates H3-K56; plays a role in regulation of Ty1 transposition 147600 RTT109 850658 RTT109 Saccharomyces cerevisiae Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase, acetylates H3-K56; plays a role in regulation of Ty1 transposition NP_013099.1 146290 D 4932 CDS NP_013100.1 6323028 850686 147889..150162 1 NC_001144.4 Dynamin-related GTPase required for mitochondrial fission and the maintenance of mitochondrial morphology, assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis; Dnm1p 150162 DNM1 850686 DNM1 Saccharomyces cerevisiae Dnm1p NP_013100.1 147889 D 4932 CDS NP_013101.1 6323029 850687 complement(151388..153976) 1 NC_001144.4 Ylr001cp; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR001C is not an essential gene 153976 850687 YLR001C Saccharomyces cerevisiae Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR001C is not an essential gene NP_013101.1 151388 R 4932 CDS NP_013102.1 6323030 850688 complement(154342..156333) 1 NC_001144.4 Protein that forms a nuclear complex with Noc2p that binds to 66S ribosomal precursors to mediate their intranuclear transport; also binds to chromatin to promote the association of DNA replication factors and replication initiation; Noc3p 156333 NOC3 850688 NOC3 Saccharomyces cerevisiae Noc3p NP_013102.1 154342 R 4932 CDS NP_013103.1 6323031 850689 complement(156854..157729) 1 NC_001144.4 Ylr003cp; Putative protein of unknown function that may participate in DNA replication; green fluorescent protein (GFP)-fusion protein is localized to the nucleus; YLR003C is not an essential gene 157729 850689 YLR003C Saccharomyces cerevisiae Putative protein of unknown function that may participate in DNA replication; green fluorescent protein (GFP)-fusion protein is localized to the nucleus; YLR003C is not an essential gene NP_013103.1 156854 R 4932 CDS NP_013104.1 6323032 850690 complement(157933..159504) 1 NC_001144.4 Thi73p; Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs 159504 THI73 850690 THI73 Saccharomyces cerevisiae Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs NP_013104.1 157933 R 4932 CDS NP_013105.1 6323033 850691 160048..161433 1 NC_001144.4 Ssl1p; Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p 161433 SSL1 850691 SSL1 Saccharomyces cerevisiae Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p NP_013105.1 160048 D 4932 CDS NP_013106.1 6323034 850692 complement(161754..163892) 1 NC_001144.4 Ssk1p; Cytoplasmic response regulator, part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate 163892 SSK1 850692 SSK1 Saccharomyces cerevisiae Cytoplasmic response regulator, part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate NP_013106.1 161754 R 4932 CDS NP_013107.1 6323035 850693 164391..165401 1 NC_001144.4 Nse1p; Essential subunit of the Mms21-Smc5-Smc6 complex; nuclear protein required for DNA repair and growth 165401 NSE1 850693 NSE1 Saccharomyces cerevisiae Essential subunit of the Mms21-Smc5-Smc6 complex; nuclear protein required for DNA repair and growth NP_013107.1 164391 D 4932 CDS NP_013108.1 6323036 850694 complement(165576..166082) 1 NC_001144.4 Pam18p; J-protein co-chaperone of the mitochondrial import motor associated with the presequence translocase, with Ssc1p, Tim44p, Mge1p, and Pam16p; stimulates ATPase activity of Ssc1p to drive mitochondrial import; activity is inhibited by Pam16p 166082 PAM18 850694 PAM18 Saccharomyces cerevisiae J-protein co-chaperone of the mitochondrial import motor associated with the presequence translocase, with Ssc1p, Tim44p, Mge1p, and Pam16p; stimulates ATPase activity of Ssc1p to drive mitochondrial import; activity is inhibited by Pam16p NP_013108.1 165576 R 4932 CDS NP_013109.1 6323037 850695 166536..167135 1 NC_001144.4 Rlp24p; Essential protein with similarity to Rpl24Ap and Rpl24Bp, associated with pre-60S ribosomal subunits and required for ribosomal large subunit biogenesis 167135 RLP24 850695 RLP24 Saccharomyces cerevisiae Essential protein with similarity to Rpl24Ap and Rpl24Bp, associated with pre-60S ribosomal subunits and required for ribosomal large subunit biogenesis NP_013109.1 166536 D 4932 CDS NP_013110.1 6323038 850696 complement(167319..167801) 1 NC_001144.4 Ten1p; Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p 167801 TEN1 850696 TEN1 Saccharomyces cerevisiae Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p NP_013110.1 167319 R 4932 CDS NP_013111.1 6323039 850698 169102..169677 1 NC_001144.4 Lot6p; FMN-dependent NAD(P)H:quinone reductase that may be involved in quinone detoxification; gene expression increases in cultures shifted to a lower temperature 169677 LOT6 850698 LOT6 Saccharomyces cerevisiae FMN-dependent NAD(P)H:quinone reductase that may be involved in quinone detoxification; gene expression increases in cultures shifted to a lower temperature NP_013111.1 169102 D 4932 CDS NP_013112.2 37362676 850699 complement(169981..170280) 1 NC_001144.4 Ylr012cp; Putative protein of unknown function; YLR012C is not an essential gene 170280 850699 YLR012C Saccharomyces cerevisiae Putative protein of unknown function; YLR012C is not an essential gene NP_013112.2 169981 R 4932 CDS NP_013113.1 6323041 850700 171338..171763 1 NC_001144.4 Protein containing GATA family zinc finger motifs; Gat3p 171763 GAT3 850700 GAT3 Saccharomyces cerevisiae Gat3p NP_013113.1 171338 D 4932 CDS NP_013114.1 6323042 850701 complement(172267..174981) 1 NC_001144.4 Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of genes involved in uracil biosynthesis; activity may be modulated by interaction with Tup1p; Ppr1p 174981 PPR1 850701 PPR1 Saccharomyces cerevisiae Ppr1p NP_013114.1 172267 R 4932 CDS NP_013115.1 6323043 850702 175226..176743 1 NC_001144.4 Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; involved in telomere maintenance; similar to trithorax-group protein ASH2L; Bre2p 176743 BRE2 850702 BRE2 Saccharomyces cerevisiae Bre2p NP_013115.1 175226 D 4932 CDS NP_013116.1 6323044 850703 complement(176801..177415) 1 NC_001144.4 Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p; Pml1p 177415 PML1 850703 PML1 Saccharomyces cerevisiae Pml1p NP_013116.1 176801 R 4932 CDS NP_013117.1 6323045 850704 177607..178620 1 NC_001144.4 Meu1p; Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression 178620 MEU1 850704 MEU1 Saccharomyces cerevisiae Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression NP_013117.1 177607 D 4932 CDS NP_013118.1 6323046 850705 complement(178706..179605) 1 NC_001144.4 Pom34p; Integral membrane protein of the nuclear pore; has an important role in maintaining the architecture of the pore complex 179605 POM34 850705 POM34 Saccharomyces cerevisiae Integral membrane protein of the nuclear pore; has an important role in maintaining the architecture of the pore complex NP_013118.1 178706 R 4932 CDS NP_013119.1 6323047 850706 180287..181480 1 NC_001144.4 Psr2p; Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p 181480 PSR2 850706 PSR2 Saccharomyces cerevisiae Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p NP_013119.1 180287 D 4932 CDS NP_013120.1 6323048 850707 complement(181788..183404) 1 NC_001144.4 Yeh2p; Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism 183404 YEH2 850707 YEH2 Saccharomyces cerevisiae Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism NP_013120.1 181788 R 4932 CDS NP_013121.1 6323049 850708 183622..184161 1 NC_001144.4 Irc25p; Chaperone component involved in 20S proteasome assembly; forms a heterodimer with Poc4p; IRC25 is a non-essential gene; null mutant displays increased levels of spontaneous Rad52 foci 184161 IRC25 850708 IRC25 Saccharomyces cerevisiae Chaperone component involved in 20S proteasome assembly; forms a heterodimer with Poc4p; IRC25 is a non-essential gene; null mutant displays increased levels of spontaneous Rad52 foci NP_013121.1 183622 D 4932 CDS NP_013122.1 6323050 850709 complement(184173..184925) 1 NC_001144.4 Sdo1p; Essential protein involved in 60S ribosome maturation; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archae and eukaryotes 184925 SDO1 850709 SDO1 Saccharomyces cerevisiae Essential protein involved in 60S ribosome maturation; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archae and eukaryotes NP_013122.1 184173 R 4932 CDS NP_013123.1 6323051 850710 complement(185497..187128) 1 NC_001144.4 Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity; Izh3p 187128 IZH3 850710 IZH3 Saccharomyces cerevisiae Izh3p NP_013123.1 185497 R 4932 CDS NP_013124.1 6323052 850711 complement(187664..193282) 1 NC_001144.4 Ubr2p; Cytoplasmic ubiquitin-protein ligase (E3) 193282 UBR2 850711 UBR2 Saccharomyces cerevisiae Cytoplasmic ubiquitin-protein ligase (E3) NP_013124.1 187664 R 4932 CDS NP_013125.1 6323053 850712 194453..195175 1 NC_001144.4 Snf7p; One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes 195175 SNF7 850712 SNF7 Saccharomyces cerevisiae One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes NP_013125.1 194453 D 4932 CDS NP_013126.1 6323054 850713 complement(195451..196473) 1 NC_001144.4 cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins; Sed5p 196473 SED5 850713 SED5 Saccharomyces cerevisiae Sed5p NP_013126.1 195451 R 4932 CDS NP_013127.2 37362677 850714 complement(196830..198086) 1 NC_001144.4 Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells; Aat2p 198086 AAT2 850714 AAT2 Saccharomyces cerevisiae Aat2p NP_013127.2 196830 R 4932 CDS NP_013128.1 6323056 850715 complement(199541..201316) 1 NC_001144.4 Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade17p; ade16 ade17 mutants require adenine and histidine; Ade16p 201316 ADE16 850715 ADE16 Saccharomyces cerevisiae Ade16p NP_013128.1 199541 R 4932 CDS NP_013129.1 6323057 850716 complement(201977..202591) 1 NC_001144.4 Rpl15ap; Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Bp and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA 202591 RPL15A 850716 RPL15A Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Bp and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA NP_013129.1 201977 R 4932 CDS NP_013130.1 6323058 850717 203291..204082 1 NC_001144.4 Ylr030wp; Putative protein of unknown function 204082 850717 YLR030W Saccharomyces cerevisiae Putative protein of unknown function NP_013130.1 203291 D 4932 CDS NP_013131.1 6323059 850718 204226..204786 1 NC_001144.4 Ylr031wp; Putative protein of unknown function 204786 850718 YLR031W Saccharomyces cerevisiae Putative protein of unknown function NP_013131.1 204226 D 4932 CDS NP_013132.1 6323060 850719 204992..208501 1 NC_001144.4 Rad5p; DNA helicase proposed to promote replication fork regression during postreplication repair by template switching; contains RING finger domain 208501 RAD5 850719 RAD5 Saccharomyces cerevisiae DNA helicase proposed to promote replication fork regression during postreplication repair by template switching; contains RING finger domain NP_013132.1 204992 D 4932 CDS NP_013133.1 6323061 850720 208762..210270 1 NC_001144.4 Rsc58p; Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance58KDa subunit 210270 RSC58 850720 RSC58 Saccharomyces cerevisiae Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance58KDa subunit NP_013133.1 208762 D 4932 CDS NP_013134.1 6323062 850721 complement(210513..211934) 1 NC_001144.4 Smf3p; Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins 211934 SMF3 850721 SMF3 Saccharomyces cerevisiae Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins NP_013134.1 210513 R 4932 CDS NP_013135.1 6323063 850722 complement(212370..214457) 1 NC_001144.4 Protein involved in the mismatch repair of certain frameshift intermediates and involved in meiotic recombination; forms a complex with Mlh1p; Mlh2p 214457 MLH2 850722 MLH2 Saccharomyces cerevisiae Mlh2p NP_013135.1 212370 R 4932 CDS NP_013136.1 6323064 850724 complement(215441..218908) 1 NC_001144.4 Ylr035c-ap; Retrotransposon TYA Gag and TYB Pol genes; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); YLR035C-A is part of a mutant retrotransposon 218908 850724 YLR035C-A Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); YLR035C-A is part of a mutant retrotransposon NP_013136.1 215441 R 4932 CDS NP_013137.1 6323065 850725 complement(221522..222133) 1 NC_001144.4 Ylr036cp; Putative protein of unknown function predicted to have transmembrane domains; interacts with HSP90 by yeast two-hybrid analysis; YLR036C is not an essential protein 222133 850725 YLR036C Saccharomyces cerevisiae Putative protein of unknown function predicted to have transmembrane domains; interacts with HSP90 by yeast two-hybrid analysis; YLR036C is not an essential protein NP_013137.1 221522 R 4932 CDS NP_013138.1 6323066 850726 complement(222686..223060) 1 NC_001144.4 Dan2p; Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth 223060 DAN2 850726 DAN2 Saccharomyces cerevisiae Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth NP_013138.1 222686 R 4932 CDS NP_013139.1 6323067 850727 complement(224922..225173) 1 NC_001144.4 Subunit VIb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; Cox12p 225173 COX12 850727 COX12 Saccharomyces cerevisiae Cox12p NP_013139.1 224922 R 4932 CDS NP_013140.1 6323068 850728 complement(225427..228597) 1 NC_001144.4 Ric1p; Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes 228597 RIC1 850728 RIC1 Saccharomyces cerevisiae Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes NP_013140.1 225427 R 4932 CDS NP_013141.1 6323070 850730 complement(228909..229583) 1 NC_001144.4 Ylr040cp; Putative protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; YLR040C is not essential 229583 850730 YLR040C Saccharomyces cerevisiae Putative protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; YLR040C is not essential NP_013141.1 228909 R 4932 CDS NP_013143.1 6323071 850731 complement(229967..230452) 1 NC_001144.4 Ylr042cp; Protein of unknown function; localizes to the cytoplasm; YLL042C is not an essential gene 230452 850731 YLR042C Saccharomyces cerevisiae Protein of unknown function; localizes to the cytoplasm; YLL042C is not an essential gene NP_013143.1 229967 R 4932 CDS NP_013144.1 6323072 850732 complement(231703..232014) 1 NC_001144.4 Trx1p; Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance 232014 TRX1 850732 TRX1 Saccharomyces cerevisiae Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance NP_013144.1 231703 R 4932 CDS NP_013145.1 6323073 850733 complement(232391..234082) 1 NC_001144.4 Pdc1p; Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism 234082 PDC1 850733 PDC1 Saccharomyces cerevisiae Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism NP_013145.1 232391 R 4932 CDS NP_013146.1 6323074 850734 complement(235038..237704) 1 NC_001144.4 Stu2p; Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p 237704 STU2 850734 STU2 Saccharomyces cerevisiae Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p NP_013146.1 235038 R 4932 CDS NP_013147.1 6323075 850735 complement(238002..238814) 1 NC_001144.4 Rla1p; Putative membrane protein, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance 238814 RLA1 850735 RLA1 Saccharomyces cerevisiae Putative membrane protein, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance NP_013147.1 238002 R 4932 CDS NP_013148.1 6323076 850736 complement(239348..241408) 1 NC_001144.4 Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p; Fre8p 241408 FRE8 850736 FRE8 Saccharomyces cerevisiae Fre8p NP_013148.1 239348 R 4932 CDS NP_013149.1 6323077 850737 join(242233..242322,242682..243350) 1 NC_001144.4 Rps0bp; Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Ap; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal 243350 RPS0B 850737 RPS0B Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Ap; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal NP_013149.1 242233 D 4932 CDS NP_013150.1 6323078 850738 complement(243887..245173) 1 NC_001144.4 Ylr049cp; Putative protein of unknown function 245173 850738 YLR049C Saccharomyces cerevisiae Putative protein of unknown function NP_013150.1 243887 R 4932 CDS NP_013151.1 6323079 850739 complement(245588..246073) 1 NC_001144.4 Ylr050cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR050C is not an essential gene 246073 850739 YLR050C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR050C is not an essential gene NP_013151.1 245588 R 4932 CDS NP_013152.1 6323080 850740 complement(246325..246978) 1 NC_001144.4 Fcf2p; Essential nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon 246978 FCF2 850740 FCF2 Saccharomyces cerevisiae Essential nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon NP_013152.1 246325 R 4932 CDS NP_013153.1 6323081 850741 247202..247954 1 NC_001144.4 Subunit of the INO80 chromatin remodeling complex; Ies3p 247954 IES3 850741 IES3 Saccharomyces cerevisiae Ies3p NP_013153.1 247202 D 4932 CDS NP_013154.1 6323082 850742 complement(248101..248427) 1 NC_001144.4 Ylr053cp; Putative protein of unknown function 248427 850742 YLR053C Saccharomyces cerevisiae Putative protein of unknown function NP_013154.1 248101 R 4932 CDS NP_013155.2 37362678 850743 complement(join(248718..250861,250949..250979)) 1 NC_001144.4 Protein of unknown function proposed to be involved in the assembly of the spore wall; Osw2p 250979 OSW2 850743 OSW2 Saccharomyces cerevisiae Osw2p NP_013155.2 248718 R 4932 CDS NP_013156.1 6323084 850744 complement(251273..253081) 1 NC_001144.4 Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters; Spt8p 253081 SPT8 850744 SPT8 Saccharomyces cerevisiae Spt8p NP_013156.1 251273 R 4932 CDS NP_013157.1 6323085 850745 253862..254959 1 NC_001144.4 Erg3p; C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources 254959 ERG3 850745 ERG3 Saccharomyces cerevisiae C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources NP_013157.1 253862 D 4932 CDS NP_013158.1 6323086 850746 255307..257856 1 NC_001144.4 Ylr057wp; Putative protein of unknown function; YLR050C is not an essential gene 257856 850746 YLR057W Saccharomyces cerevisiae Putative protein of unknown function; YLR050C is not an essential gene NP_013158.1 255307 D 4932 CDS NP_013159.1 6323087 850747 complement(257993..259402) 1 NC_001144.4 Shm2p; Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis 259402 SHM2 850747 SHM2 Saccharomyces cerevisiae Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis NP_013159.1 257993 R 4932 CDS NP_013160.1 6323088 850748 complement(259739..260548) 1 NC_001144.4 Rex2p; RNA exonuclease, required for U4 snRNA maturation; functions redundantly with Rnh70p in 5.8S rRNA maturation, and with Rnh70p and Rex3p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases 260548 REX2 850748 REX2 Saccharomyces cerevisiae RNA exonuclease, required for U4 snRNA maturation; functions redundantly with Rnh70p in 5.8S rRNA maturation, and with Rnh70p and Rex3p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases NP_013160.1 259739 R 4932 CDS NP_013161.1 6323089 850749 260980..262767 1 NC_001144.4 Frs1p; Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; sequence is evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase (Msf1p), but substrate binding is similar 262767 FRS1 850749 FRS1 Saccharomyces cerevisiae Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; sequence is evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase (Msf1p), but substrate binding is similar NP_013161.1 260980 D 4932 CDS NP_013162.1 6323090 850750 join(263195..263206,263596..263949) 1 NC_001144.4 Rpl22ap; Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Bp and to rat L22 ribosomal protein 263949 RPL22A 850750 RPL22A Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Bp and to rat L22 ribosomal protein NP_013162.1 263195 D 4932 CDS NP_013164.1 6323092 850752 264158..265255 1 NC_001144.4 Ylr063wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene 265255 850752 YLR063W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene NP_013164.1 264158 D 4932 CDS NP_013165.1 6323093 850753 265457..266278 1 NC_001144.4 Ylr064wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR064W is not an essential gene 266278 850753 YLR064W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR064W is not an essential gene NP_013165.1 265457 D 4932 CDS NP_013166.1 6323094 850754 complement(266374..266919) 1 NC_001144.4 Ylr065cp; Putative protein of unknown function; YLR065C is not an essential gene 266919 850754 YLR065C Saccharomyces cerevisiae Putative protein of unknown function; YLR065C is not an essential gene NP_013166.1 266374 R 4932 CDS NP_013167.1 6323095 850755 267170..267724 1 NC_001144.4 Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23; Spc3p 267724 SPC3 850755 SPC3 Saccharomyces cerevisiae Spc3p NP_013167.1 267170 D 4932 CDS NP_013168.1 6323096 850756 complement(267814..270711) 1 NC_001144.4 Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; located in the mitochondrial inner membrane; Pet309p 270711 PET309 850756 PET309 Saccharomyces cerevisiae Pet309p NP_013168.1 267814 R 4932 CDS NP_013169.1 6323097 850757 271009..271464 1 NC_001144.4 Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in processing the 35S rRNA primary transcript to generate the 20S and 27SA2 pre-rRNA transcripts; Fyv7p 271464 FYV7 850757 FYV7 Saccharomyces cerevisiae Fyv7p NP_013169.1 271009 D 4932 CDS NP_013170.1 6323098 850758 complement(271631..273916) 1 NC_001144.4 Mitochondrial elongation factor involved in translational elongation; Mef1p 273916 MEF1 850758 MEF1 Saccharomyces cerevisiae Mef1p NP_013170.1 271631 R 4932 CDS NP_013171.1 6323099 850759 complement(274142..275212) 1 NC_001144.4 Xylitol dehydrogenase, converts xylitol to D-xylulose in the endogenous xylose utilization pathway; Xyl2p 275212 XYL2 850759 XYL2 Saccharomyces cerevisiae Xyl2p NP_013171.1 274142 R 4932 CDS NP_013172.1 6323100 850760 complement(275379..278627) 1 NC_001144.4 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation; Rgr1p 278627 RGR1 850760 RGR1 Saccharomyces cerevisiae Rgr1p NP_013172.1 275379 R 4932 CDS NP_013173.1 6323101 850761 278863..280944 1 NC_001144.4 Ylr072wp; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YLR072W is not an esssential gene 280944 850761 YLR072W Saccharomyces cerevisiae Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YLR072W is not an esssential gene NP_013173.1 278863 D 4932 CDS NP_013174.1 6323102 850762 complement(281020..281622) 1 NC_001144.4 Ylr073cp; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to endosomes; YLR073C is not an esssential gene 281622 850762 YLR073C Saccharomyces cerevisiae Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to endosomes; YLR073C is not an esssential gene NP_013174.1 281020 R 4932 CDS NP_013175.1 6323103 850763 complement(281957..282457) 1 NC_001144.4 Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; Bud20p 282457 BUD20 850763 BUD20 Saccharomyces cerevisiae Bud20p NP_013175.1 281957 R 4932 CDS NP_013176.1 6323104 850764 282928..283593 1 NC_001144.4 Rpl10p; Protein component of the large (60S) ribosomal subunit, responsible for joining the 40S and 60S subunits; regulates translation initiation; has similarity to rat L10 ribosomal protein and to members of the QM gene family 283593 RPL10 850764 RPL10 Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, responsible for joining the 40S and 60S subunits; regulates translation initiation; has similarity to rat L10 ribosomal protein and to members of the QM gene family NP_013176.1 282928 D 4932 CDS NP_013178.1 6323106 850766 283873..285624 1 NC_001144.4 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Fmp25p 285624 FMP25 850766 FMP25 Saccharomyces cerevisiae Fmp25p NP_013178.1 283873 D 4932 CDS NP_013179.1 6323107 850767 complement(join(285737..286468,286558..286560)) 1 NC_001144.4 v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi; Bos1p 286560 BOS1 850767 BOS1 Saccharomyces cerevisiae Bos1p NP_013179.1 285737 R 4932 CDS NP_013180.1 6323108 850768 286821..287675 1 NC_001144.4 Sic1p; Inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1 287675 SIC1 850768 SIC1 Saccharomyces cerevisiae Inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1 NP_013180.1 286821 D 4932 CDS NP_013181.1 6323109 850769 287917..289251 1 NC_001144.4 Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport; Emp46p 289251 EMP46 850769 EMP46 Saccharomyces cerevisiae Emp46p NP_013181.1 287917 D 4932 CDS NP_013182.1 6323110 850770 290213..291937 1 NC_001144.4 Galactose permease, required for utilization of galactose; also able to transport glucose; Gal2p 291937 GAL2 850770 GAL2 Saccharomyces cerevisiae Gal2p NP_013182.1 290213 D 4932 CDS NP_013183.1 6323111 850771 complement(292395..293573) 1 NC_001144.4 Srl2p; Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation 293573 SRL2 850771 SRL2 Saccharomyces cerevisiae Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation NP_013183.1 292395 R 4932 CDS NP_013184.1 6323112 850772 complement(294092..296095) 1 NC_001144.4 Protein whose 24kDa cleavage product is found in endosome-enriched membrane fractions, predicted to be a transmembrane protein; Emp70p 296095 EMP70 850772 EMP70 Saccharomyces cerevisiae Emp70p NP_013184.1 294092 R 4932 CDS NP_013185.1 6323113 850773 complement(296590..300252) 1 NC_001144.4 Rax2p; N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p 300252 RAX2 850773 RAX2 Saccharomyces cerevisiae N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p NP_013185.1 296590 R 4932 CDS NP_013186.1 6323114 850774 complement(300674..301990) 1 NC_001144.4 Arp6p; Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A 301990 ARP6 850774 ARP6 Saccharomyces cerevisiae Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A NP_013186.1 300674 R 4932 CDS NP_013187.1 6323115 850775 302244..306500 1 NC_001144.4 Subunit of the condensin complex, which reorganizes chromosomes during cell division, forms a stable complex with Smc2p that has ATP-hydrolyzing and DNA-binding activity and promotes knotting of circular DNA; potential Cdc28p substrate; Smc4p 306500 SMC4 850775 SMC4 Saccharomyces cerevisiae Smc4p NP_013187.1 302244 D 4932 CDS NP_013188.1 6323116 850776 complement(306856..315732) 1 NC_001144.4 Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Csf1p 315732 CSF1 850776 CSF1 Saccharomyces cerevisiae Csf1p NP_013188.1 306856 R 4932 CDS NP_013189.1 6323117 850777 316108..317952 1 NC_001144.4 Subunit of the GPI (glycosylphosphatidylinositol):protein transamidase complex, removes the GPI-anchoring signal and attaches GPI to proteins in the ER; Gaa1p 317952 GAA1 850777 GAA1 Saccharomyces cerevisiae Gaa1p NP_013189.1 316108 D 4932 CDS NP_013190.1 6323118 850778 complement(318238..320016) 1 NC_001144.4 Putative alanine transaminase (glutamic pyruvic transaminase); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Alt1p 320016 ALT1 850778 ALT1 Saccharomyces cerevisiae Alt1p NP_013190.1 318238 R 4932 CDS NP_013191.1 6323119 850779 320702..322081 1 NC_001144.4 Xdj1p; Putative chaperone, homolog of E. coli DnaJ, closely related to Ydj1p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 322081 XDJ1 850779 XDJ1 Saccharomyces cerevisiae Putative chaperone, homolog of E. coli DnaJ, closely related to Ydj1p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_013191.1 320702 D 4932 CDS NP_013192.1 6323120 850780 322298..323179 1 NC_001144.4 Ylr091wp; Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR091W is not an esssential gene 323179 850780 YLR091W Saccharomyces cerevisiae Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR091W is not an esssential gene NP_013192.1 322298 D 4932 CDS NP_013193.1 6323121 850781 323545..326226 1 NC_001144.4 Sul2p; High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates 326226 SUL2 850781 SUL2 Saccharomyces cerevisiae High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates NP_013193.1 323545 D 4932 CDS NP_013194.2 9755337 850782 complement(join(326514..327259,327401..327416)) 1 NC_001144.4 v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane; Nyv1p 327416 NYV1 850782 NYV1 Saccharomyces cerevisiae Nyv1p NP_013194.2 326514 R 4932 CDS NP_013195.1 6323123 850783 complement(327731..329239) 1 NC_001144.4 Gis3p 329239 GIS3 850783 GIS3 Saccharomyces cerevisiae Gis3p NP_013195.1 327731 R 4932 CDS NP_013196.1 6323124 850784 complement(329678..332116) 1 NC_001144.4 Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif; Ioc2p 332116 IOC2 850784 IOC2 Saccharomyces cerevisiae Ioc2p NP_013196.1 329678 R 4932 CDS NP_013197.1 6323125 850785 332591..336034 1 NC_001144.4 Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin1p; Kin2p 336034 KIN2 850785 KIN2 Saccharomyces cerevisiae Kin2p NP_013197.1 332591 D 4932 CDS NP_013198.1 6323126 850786 complement(336232..337266) 1 NC_001144.4 Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies; Hrt3p 337266 HRT3 850786 HRT3 Saccharomyces cerevisiae Hrt3p NP_013198.1 336232 R 4932 CDS NP_013199.1 6323127 850787 complement(337528..339474) 1 NC_001144.4 DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain; Cha4p 339474 CHA4 850787 CHA4 Saccharomyces cerevisiae Cha4p NP_013199.1 337528 R 4932 CDS NP_013200.1 6323128 850788 complement(339745..340929) 1 NC_001144.4 Protein of unknown function, null mutation leads to an increase in sensitivity to Calcofluor white; expression of the gene is induced in the presence of isooctane; Ict1p 340929 ICT1 850788 ICT1 Saccharomyces cerevisiae Ict1p NP_013200.1 339745 R 4932 CDS NP_076901.1 13129179 850789 341326..341589 1 NC_001144.4 Ylr099w-ap; Putative protein of unknown function 341589 850789 YLR099W-A Saccharomyces cerevisiae Putative protein of unknown function NP_076901.1 341326 D 4932 CDS NP_013201.1 6323129 850790 341811..342854 1 NC_001144.4 Erg27p; 3-keto sterol reductase, catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs 342854 ERG27 850790 ERG27 Saccharomyces cerevisiae 3-keto sterol reductase, catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs NP_013201.1 341811 D 4932 CDS NP_013203.1 6323131 850792 complement(342971..343768) 1 NC_001144.4 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; Apc9p 343768 APC9 850792 APC9 Saccharomyces cerevisiae Apc9p NP_013203.1 342971 R 4932 CDS NP_013204.1 6323132 850793 complement(343990..345942) 1 NC_001144.4 DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes; Cdc45p 345942 CDC45 850793 CDC45 Saccharomyces cerevisiae Cdc45p NP_013204.1 343990 R 4932 CDS NP_013205.1 6323133 850794 346586..346981 1 NC_001144.4 Ylr104wp; Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate 346981 850794 YLR104W Saccharomyces cerevisiae Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate NP_013205.1 346586 D 4932 CDS NP_013206.1 6323134 850795 complement(347048..348181) 1 NC_001144.4 Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease; Sen2p 348181 SEN2 850795 SEN2 Saccharomyces cerevisiae Sen2p NP_013206.1 347048 R 4932 CDS NP_013207.1 6323135 850796 complement(349007..363739) 1 NC_001144.4 Mdn1p; Huge dynein-related AAA-type ATPase (midasin), forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p), may mediate ATP-dependent remodeling of 60S subunits and subsequent export from nucleoplasm to cytoplasm 363739 MDN1 850796 MDN1 Saccharomyces cerevisiae Huge dynein-related AAA-type ATPase (midasin), forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p), may mediate ATP-dependent remodeling of 60S subunits and subsequent export from nucleoplasm to cytoplasm NP_013207.1 349007 R 4932 CDS NP_013208.1 6323136 850797 364117..365331 1 NC_001144.4 Rex3p; RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases 365331 REX3 850797 REX3 Saccharomyces cerevisiae RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases NP_013208.1 364117 D 4932 CDS NP_013209.1 6323137 850798 complement(366668..368125) 1 NC_001144.4 Ylr108cp; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene 368125 850798 YLR108C Saccharomyces cerevisiae Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene NP_013209.1 366668 R 4932 CDS NP_013210.1 6323138 850799 368782..369312 1 NC_001144.4 Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p; Ahp1p 369312 AHP1 850799 AHP1 Saccharomyces cerevisiae Ahp1p NP_013210.1 368782 D 4932 CDS NP_013211.1 6323139 850800 complement(369698..370099) 1 NC_001144.4 Cell wall mannoprotein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor; Ccw12p 370099 CCW12 850800 CCW12 Saccharomyces cerevisiae Ccw12p NP_013211.1 369698 R 4932 CDS NP_013214.1 6323142 850803 371621..372928 1 NC_001144.4 Mitogen-activated protein kinase involved in osmoregulation via three independent osmosensors; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p; Hog1p 372928 HOG1 850803 HOG1 Saccharomyces cerevisiae Hog1p NP_013214.1 371621 D 4932 CDS NP_013215.1 6323143 850805 complement(374945..377239) 1 NC_001144.4 Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; Avl9p 377239 AVL9 850805 AVL9 Saccharomyces cerevisiae Avl9p NP_013215.1 374945 R 4932 CDS NP_013216.1 6323144 850806 377986..380565 1 NC_001144.4 Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein.; Cft2p 380565 CFT2 850806 CFT2 Saccharomyces cerevisiae Cft2p NP_013216.1 377986 D 4932 CDS NP_013217.1 6323145 850807 380823..382253 1 NC_001144.4 Msl5p; Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA 382253 MSL5 850807 MSL5 Saccharomyces cerevisiae Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA NP_013217.1 380823 D 4932 CDS NP_013218.1 6323146 850808 complement(382472..384535) 1 NC_001144.4 Essential splicesome assembly factor; contains multiple tetratricopeptide repeat (TPR) protein-binding motifs and interacts specifically with many spliceosome components, may serve as a scaffold during splicesome assembly; Clf1p 384535 CLF1 850808 CLF1 Saccharomyces cerevisiae Clf1p NP_013218.1 382472 R 4932 CDS NP_013219.1 6323147 850809 complement(384726..385409) 1 NC_001144.4 Ylr118cp; Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS 385409 850809 YLR118C Saccharomyces cerevisiae Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS NP_013219.1 384726 R 4932 CDS NP_013220.1 6323148 850810 385535..386176 1 NC_001144.4 Srn2p; Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus 386176 SRN2 850810 SRN2 Saccharomyces cerevisiae Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus NP_013220.1 385535 D 4932 CDS NP_013221.1 6323149 850811 complement(386512..388221) 1 NC_001144.4 Yps1p; Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor 388221 YPS1 850811 YPS1 Saccharomyces cerevisiae Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor NP_013221.1 386512 R 4932 CDS NP_013222.1 6323150 850812 complement(388745..390271) 1 NC_001144.4 Yps3p; Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor 390271 YPS3 850812 YPS3 Saccharomyces cerevisiae Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor NP_013222.1 388745 R 4932 CDS NP_013226.1 6323154 850816 393485..393895 1 NC_001144.4 Ylr125wp; Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene 393895 850816 YLR125W Saccharomyces cerevisiae Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene NP_013226.1 393485 D 4932 CDS NP_013227.1 6323155 850817 complement(394766..395521) 1 NC_001144.4 Ylr126cp; Putative protein of unknown function with similarity to glutamine amidotransferase proteins; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein 395521 850817 YLR126C Saccharomyces cerevisiae Putative protein of unknown function with similarity to glutamine amidotransferase proteins; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein NP_013227.1 394766 R 4932 CDS NP_013228.1 6323156 850818 complement(395759..398320) 1 NC_001144.4 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; similar to cullin Cdc53p; Apc2p 398320 APC2 850818 APC2 Saccharomyces cerevisiae Apc2p NP_013228.1 395759 R 4932 CDS NP_013229.1 6323157 850819 join(398531..398533,398628..399434) 1 NC_001144.4 Putative Nedd8 ligase; binds Nedd8; involved in cullin neddylation; not essential; similar to C.elegans DCN-1; contains UBA-like ubiquitin-binding domain and a DUF298 domain; Dcn1p 399434 DCN1 850819 DCN1 Saccharomyces cerevisiae Dcn1p NP_013229.1 398531 D 4932 CDS NP_013230.1 6323158 850820 399658..402489 1 NC_001144.4 Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex; Dip2p 402489 DIP2 850820 DIP2 Saccharomyces cerevisiae Dip2p NP_013230.1 399658 D 4932 CDS NP_013231.1 6323159 850821 complement(402795..404063) 1 NC_001144.4 Zrt2p; Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor 404063 ZRT2 850821 ZRT2 Saccharomyces cerevisiae Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor NP_013231.1 402795 R 4932 CDS NP_013232.1 6323160 850822 complement(404511..406823) 1 NC_001144.4 Transcription factor that activates expression of early G1-specific genes, localizes to daughter cell nuclei after cytokinesis and delays G1 progression in daughters, localization is regulated by phosphorylation; potential Cdc28p substrate; Ace2p 406823 ACE2 850822 ACE2 Saccharomyces cerevisiae Ace2p NP_013232.1 404511 R 4932 CDS NP_013233.1 6323161 850823 complement(407284..408156) 1 NC_001144.4 Ylr132cp; Protein of unknown function; green fluorescent protein (GFP)-tagged protein localizes to mitochondria and nucleus; YLR132C is an essential gene 408156 850823 YLR132C Saccharomyces cerevisiae Protein of unknown function; green fluorescent protein (GFP)-tagged protein localizes to mitochondria and nucleus; YLR132C is an essential gene NP_013233.1 407284 R 4932 CDS NP_013234.1 6323162 850824 408446..410194 1 NC_001144.4 Cki1p; Choline kinase, catalyzing the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway 410194 CKI1 850824 CKI1 Saccharomyces cerevisiae Choline kinase, catalyzing the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway NP_013234.1 408446 D 4932 CDS NP_013235.1 6323163 850825 410724..412415 1 NC_001144.4 Pdc5p; Minor isoform of pyruvate decarboxylase, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, repressed by thiamine, involved in amino acid catabolism 412415 PDC5 850825 PDC5 Saccharomyces cerevisiae Minor isoform of pyruvate decarboxylase, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, repressed by thiamine, involved in amino acid catabolism NP_013235.1 410724 D 4932 CDS NP_013236.1 6323164 850826 413282..415528 1 NC_001144.4 Subunit of a complex, with Slx1p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p; Slx4p 415528 SLX4 850826 SLX4 Saccharomyces cerevisiae Slx4p NP_013236.1 413282 D 4932 CDS NP_013237.1 6323165 850827 complement(415802..416659) 1 NC_001144.4 mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; Tis11p 416659 TIS11 850827 TIS11 Saccharomyces cerevisiae Tis11p NP_013237.1 415802 R 4932 CDS NP_013238.1 6323166 850828 417007..418110 1 NC_001144.4 Ylr137wp; Putative protein of unknown function 418110 850828 YLR137W Saccharomyces cerevisiae Putative protein of unknown function NP_013238.1 417007 D 4932 CDS NP_013239.1 6323167 850829 418438..421395 1 NC_001144.4 Nha1p; Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH 421395 NHA1 850829 NHA1 Saccharomyces cerevisiae Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH NP_013239.1 418438 D 4932 CDS NP_013240.1 6323168 850830 complement(421543..423474) 1 NC_001144.4 Sls1p; Mitochondrial membrane protein that coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery 423474 SLS1 850830 SLS1 Saccharomyces cerevisiae Mitochondrial membrane protein that coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery NP_013240.1 421543 R 4932 CDS NP_013242.1 6323170 850832 423684..424775 1 NC_001144.4 Rrn5p; Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p 424775 RRN5 850832 RRN5 Saccharomyces cerevisiae Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p NP_013242.1 423684 D 4932 CDS NP_013243.1 6323171 850833 425187..426617 1 NC_001144.4 Put1p; Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source 426617 PUT1 850833 PUT1 Saccharomyces cerevisiae Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source NP_013243.1 425187 D 4932 CDS NP_013244.1 6323172 850835 427330..429387 1 NC_001144.4 Ylr143wp; Putative protein of unknown function; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; YLR143W is not an essential gene 429387 850835 YLR143W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; YLR143W is not an essential gene NP_013244.1 427330 D 4932 CDS NP_013245.1 6323173 850836 complement(429678..432017) 1 NC_001144.4 Intracellular beta-1,3-endoglucanase, expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; Acf2p 432017 ACF2 850836 ACF2 Saccharomyces cerevisiae Acf2p NP_013245.1 429678 R 4932 CDS NP_013246.1 6323174 850837 432169..432774 1 NC_001144.4 Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P; Rmp1p 432774 RMP1 850837 RMP1 Saccharomyces cerevisiae Rmp1p NP_013246.1 432169 D 4932 CDS NP_013247.1 6323175 850838 complement(432824..433726) 1 NC_001144.4 Spermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid; Spe4p 433726 SPE4 850838 SPE4 Saccharomyces cerevisiae Spe4p NP_013247.1 432824 R 4932 CDS NP_001032582.1 82795259 3799977 433871..434059 1 NC_001144.4 Ylr146w-ap; Putative protein of unknown function 434059 3799977 YLR146W-A Saccharomyces cerevisiae Putative protein of unknown function NP_001032582.1 433871 D 4932 CDS NP_013248.1 6323176 850839 complement(434159..434464) 1 NC_001144.4 Smd3p; Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3 434464 SMD3 850839 SMD3 Saccharomyces cerevisiae Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3 NP_013248.1 434159 R 4932 CDS NP_013249.1 6323177 850840 434642..437398 1 NC_001144.4 Pep3p; Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis 437398 PEP3 850840 PEP3 Saccharomyces cerevisiae Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis NP_013249.1 434642 D 4932 CDS NP_013250.1 6323178 850841 complement(437632..439824) 1 NC_001144.4 Ylr149cp; Putative protein of unknown function; YLR149C is not an essential gene 439824 850841 YLR149C Saccharomyces cerevisiae Putative protein of unknown function; YLR149C is not an essential gene NP_013250.1 437632 R 4932 CDS NP_013251.1 6323179 850843 440468..441289 1 NC_001144.4 Stm1p; Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppressor of tom1 and pop2 mutations 441289 STM1 850843 STM1 Saccharomyces cerevisiae Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppressor of tom1 and pop2 mutations NP_013251.1 440468 D 4932 CDS NP_013252.1 6323180 850844 complement(441716..442738) 1 NC_001144.4 Peroxisomal nudix pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; Pcd1p 442738 PCD1 850844 PCD1 Saccharomyces cerevisiae Pcd1p NP_013252.1 441716 R 4932 CDS NP_013253.1 6323181 850845 complement(442959..444689) 1 NC_001144.4 Ylr152cp; Putative protein of unknown function; YLR152C is not an essential gene 444689 850845 YLR152C Saccharomyces cerevisiae Putative protein of unknown function; YLR152C is not an essential gene NP_013253.1 442959 R 4932 CDS NP_013254.1 6323182 850846 complement(445525..447576) 1 NC_001144.4 Acs2p; Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions 447576 ACS2 850846 ACS2 Saccharomyces cerevisiae Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions NP_013254.1 445525 R 4932 CDS NP_013255.1 6323183 850847 complement(447983..448315) 1 NC_001144.4 Rnh203p; Ribonuclease H2 subunit, required for RNase H2 activity 448315 RNH203 850847 RNH203 Saccharomyces cerevisiae Ribonuclease H2 subunit, required for RNase H2 activity NP_013255.1 447983 R 4932 CDS NP_690845.1 23270399 850849 454697..455071 1 NC_001144.4 Tar1p; Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand 455071 TAR1 850849 TAR1 Saccharomyces cerevisiae Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand NP_690845.1 454697 D 4932 CDS NP_878121.1 33438833 1466409 complement(462523..462672) 1 NC_001144.4 Ylr154c-gp; Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF is contained within RDN25-2 and RDN37-2 462672 1466409 YLR154C-G Saccharomyces cerevisiae Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF is contained within RDN25-2 and RDN37-2 NP_878121.1 462523 R 4932 CDS NP_878122.1 33438834 1466410 complement(468828..468959) 1 NC_001144.4 Ylr154c-hp; Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RND5-2 468959 1466410 YLR154C-H Saccharomyces cerevisiae Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RND5-2 NP_878122.1 468828 R 4932 CDS NP_013256.1 6323184 850850 complement(469318..470406) 1 NC_001144.4 Cell-wall L-asparaginase II, involved in asparagine catabolism; expression is induced during nitrogen starvation; four copies of ASP3 are present in the genome reference strain S288C; Asp3-1p 470406 ASP3-1 850850 ASP3-1 Saccharomyces cerevisiae Asp3-1p NP_013256.1 469318 R 4932 CDS NP_757337.1 26225099 850851 472114..472458 1 NC_001144.4 Ylr156wp; Putative protein of unknown function; exhibits a two-hybrid interaction with Jsn1p in a large-scale analysis 472458 850851 YLR156W Saccharomyces cerevisiae Putative protein of unknown function; exhibits a two-hybrid interaction with Jsn1p in a large-scale analysis NP_757337.1 472114 D 4932 CDS NP_878123.1 33438835 1466411 complement(472480..472611) 1 NC_001144.4 Ylr156c-ap; Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RND5-3 472611 1466411 YLR156C-A Saccharomyces cerevisiae Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RND5-3 NP_878123.1 472480 R 4932 CDS NP_013258.1 6323186 850852 complement(472970..474058) 1 NC_001144.4 Cell-wall L-asparaginase II, involved in asparagine catabolism; expression is induced during nitrogen starvation; four copies of ASP3 are present in the genome reference strain S288C; Asp3-2p 474058 ASP3-2 850852 ASP3-2 Saccharomyces cerevisiae Asp3-2p NP_013258.1 472970 R 4932 CDS NP_878124.1 33438836 1466412 475765..475977 1 NC_001144.4 Ylr157w-dp; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 475977 1466412 YLR157W-D Saccharomyces cerevisiae Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching NP_878124.1 475765 D 4932 CDS NP_058169.1 7839185 850853 complement(join(476334..480296,480298..481602)) 1 NC_001144.4 Ylr157c-bp; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 481602 850853 YLR157C-B Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_058169.1 476334 R 4932 CDS NP_058170.1 7839184 850854 complement(480280..481602) 1 NC_001144.4 Ylr157c-ap; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 481602 850854 YLR157C-A Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_058170.1 480280 R 4932 CDS NP_878125.1 33438837 1466413 481874..482038 1 NC_001144.4 Ylr157w-ep; Putative protein of unknown function identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; partially overlaps a Ty1 element 482038 1466413 YLR157W-E Saccharomyces cerevisiae Putative protein of unknown function identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; partially overlaps a Ty1 element NP_878125.1 481874 D 4932 CDS NP_878126.1 33438838 1466414 complement(482060..482191) 1 NC_001144.4 Ylr157c-cp; Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RND5-4 482191 1466414 YLR157C-C Saccharomyces cerevisiae Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RND5-4 NP_878126.1 482060 R 4932 CDS NP_013259.1 6323187 850855 complement(482550..483638) 1 NC_001144.4 Cell-wall L-asparaginase II, involved in asparagine catabolism; expression is induced during nitrogen starvation; four copies of ASP3 are present in the genome reference strain S288C; Asp3-3p 483638 ASP3-3 850855 ASP3-3 Saccharomyces cerevisiae Asp3-3p NP_013259.1 482550 R 4932 CDS NP_757338.1 26225100 850856 485346..485690 1 NC_001144.4 Ylr159wp; Putative protein of unknown function; YLR156W, YLR159W, and YLR161W are three identical open reading frames encoded near the ribosomal DNA region of chromosome 12 485690 850856 YLR159W Saccharomyces cerevisiae Putative protein of unknown function; YLR156W, YLR159W, and YLR161W are three identical open reading frames encoded near the ribosomal DNA region of chromosome 12 NP_757338.1 485346 D 4932 CDS NP_878127.1 33438839 1466415 complement(485712..485843) 1 NC_001144.4 Ylr159c-ap; Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RND5-5 485843 1466415 YLR159C-A Saccharomyces cerevisiae Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RND5-5 NP_878127.1 485712 R 4932 CDS NP_013261.1 6323189 850857 complement(486202..487290) 1 NC_001144.4 Cell-wall L-asparaginase II, involved in asparagine catabolism; expression is induced during nitrogen starvation; four copies of ASP3 are present in the genome reference strain S288C; Asp3-4p 487290 ASP3-4 850857 ASP3-4 Saccharomyces cerevisiae Asp3-4p NP_013261.1 486202 R 4932 CDS NP_757339.1 26225101 850858 488998..489342 1 NC_001144.4 Ylr161wp; Putative protein of unknown function; YLR156W, YLR159W, and YLR161W are three identical open reading frames encoded near the ribosomal DNA region of chromosome 12 489342 850858 YLR161W Saccharomyces cerevisiae Putative protein of unknown function; YLR156W, YLR159W, and YLR161W are three identical open reading frames encoded near the ribosomal DNA region of chromosome 12 NP_757339.1 488998 D 4932 CDS NP_013263.1 6323191 850859 489574..489930 1 NC_001144.4 Ylr162wp; Putative protein of unknown function; overexpression confers resistance to the antimicrobial peptide MiAMP1 489930 850859 YLR162W Saccharomyces cerevisiae Putative protein of unknown function; overexpression confers resistance to the antimicrobial peptide MiAMP1 NP_013263.1 489574 D 4932 CDS NP_878128.1 33438840 1466416 490407..490595 1 NC_001144.4 Ylr162w-ap; Putative protein of unknown function identified by fungal homology comparisons and RT-PCR 490595 1466416 YLR162W-A Saccharomyces cerevisiae Putative protein of unknown function identified by fungal homology comparisons and RT-PCR NP_878128.1 490407 D 4932 CDS NP_013264.1 6323192 850860 complement(491868..493256) 1 NC_001144.4 Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins; Mas1p 493256 MAS1 850860 MAS1 Saccharomyces cerevisiae Mas1p NP_013264.1 491868 R 4932 CDS NP_013265.1 6323193 850861 493885..494391 1 NC_001144.4 Ylr164wp; Mitochondrial inner membrane of unknown function; similar to Tim18p and Sdh4p; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner 494391 850861 YLR164W Saccharomyces cerevisiae Mitochondrial inner membrane of unknown function; similar to Tim18p and Sdh4p; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner NP_013265.1 493885 D 4932 CDS NP_013266.1 6323194 850862 complement(494496..495260) 1 NC_001144.4 Pus5p; Pseudouridine synthase, catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability 495260 PUS5 850862 PUS5 Saccharomyces cerevisiae Pseudouridine synthase, catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability NP_013266.1 494496 R 4932 CDS NP_013267.1 6323195 850863 complement(495431..498046) 1 NC_001144.4 Sec10p; Essential 100kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis 498046 SEC10 850863 SEC10 Saccharomyces cerevisiae Essential 100kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis NP_013267.1 495431 R 4932 CDS NP_013268.1 6323196 850864 498949..499407 1 NC_001144.4 Rps31p; Fusion protein that is cleaved to yield a ribosomal protein of the small (40S) subunit and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B 499407 RPS31 850864 RPS31 Saccharomyces cerevisiae Fusion protein that is cleaved to yield a ribosomal protein of the small (40S) subunit and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B NP_013268.1 498949 D 4932 CDS NP_013269.1 6323197 850865 complement(499580..500272) 1 NC_001144.4 Putative protein of unknown function that may be involved in intramitochondrial sorting; similar to Ups1p and to human PRELI; GFP-tagged protein localizes to mitochondria; required for wild-type respiratory growth; Aim30p 500272 AIM30 850865 AIM30 Saccharomyces cerevisiae Aim30p NP_013269.1 499580 R 4932 CDS NP_013271.1 6323200 850868 complement(500581..501051) 1 NC_001144.4 Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex; Aps1p 501051 APS1 850868 APS1 Saccharomyces cerevisiae Aps1p NP_013271.1 500581 R 4932 CDS NP_013273.1 6323201 850869 complement(501262..502164) 1 NC_001144.4 Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm; Dph5p 502164 DPH5 850869 DPH5 Saccharomyces cerevisiae Dph5p NP_013273.1 501262 R 4932 CDS NP_013274.1 6323202 850870 502423..504249 1 NC_001144.4 Ylr173wp; Putative protein of unknown function 504249 850870 YLR173W Saccharomyces cerevisiae Putative protein of unknown function NP_013274.1 502423 D 4932 CDS NP_013275.1 6323203 850871 504593..505831 1 NC_001144.4 Idp2p; Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose 505831 IDP2 850871 IDP2 Saccharomyces cerevisiae Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose NP_013275.1 504593 D 4932 CDS NP_013276.1 6323204 850872 506136..507587 1 NC_001144.4 Pseudouridine synthase catalytic subunit of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), acts on both large and small rRNAs and on snRNA U2; Cbf5p 507587 CBF5 850872 CBF5 Saccharomyces cerevisiae Cbf5p NP_013276.1 506136 D 4932 CDS NP_013277.1 6323205 850873 complement(507799..510234) 1 NC_001144.4 Rfx1p; Protein involved in DNA damage and replication checkpoint pathway; recruits repressors Tup1p and Cyc8p to promoters of DNA damage-inducible genes; similar to a family of mammalian DNA binding RFX1-4 proteins 510234 RFX1 850873 RFX1 Saccharomyces cerevisiae Protein involved in DNA damage and replication checkpoint pathway; recruits repressors Tup1p and Cyc8p to promoters of DNA damage-inducible genes; similar to a family of mammalian DNA binding RFX1-4 proteins NP_013277.1 507799 R 4932 CDS NP_013278.1 6323206 850874 511056..512942 1 NC_001144.4 Ylr177wp; Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; YLR177W is not an essential gene 512942 850874 YLR177W Saccharomyces cerevisiae Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; YLR177W is not an essential gene NP_013278.1 511056 D 4932 CDS NP_013279.1 6323207 850875 complement(513164..513823) 1 NC_001144.4 Tfs1p; Carboxypeptidase Y inhibitor, function requires acetylation by the NatB N-terminal acetyltransferase; phosphatidylethanolamine-binding protein involved in protein kinase A signaling pathway 513823 TFS1 850875 TFS1 Saccharomyces cerevisiae Carboxypeptidase Y inhibitor, function requires acetylation by the NatB N-terminal acetyltransferase; phosphatidylethanolamine-binding protein involved in protein kinase A signaling pathway NP_013279.1 513164 R 4932 CDS NP_013280.1 6323208 850876 complement(514110..514715) 1 NC_001144.4 Ylr179cp; Protein of unknown function, transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus; YLR179C is not essential 514715 850876 YLR179C Saccharomyces cerevisiae Protein of unknown function, transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus; YLR179C is not essential NP_013280.1 514110 R 4932 CDS NP_013281.1 6323209 850877 515264..516412 1 NC_001144.4 Sam1p; S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p) 516412 SAM1 850877 SAM1 Saccharomyces cerevisiae S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p) NP_013281.1 515264 D 4932 CDS NP_013282.1 6323210 850878 complement(516680..517672) 1 NC_001144.4 Vta1p; Multivesicular body (MVB) protein involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligimeriztion; binds to Vps4p, Vps20p, and Vps60p; may act at a late step in MVB formation 517672 VTA1 850878 VTA1 Saccharomyces cerevisiae Multivesicular body (MVB) protein involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligimeriztion; binds to Vps4p, Vps20p, and Vps60p; may act at a late step in MVB formation NP_013282.1 516680 R 4932 CDS NP_013283.1 6323211 850879 517942..520353 1 NC_001144.4 Transcription cofactor, forms complexes with DNA-binding proteins Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; localization regulated by phosphorylation; potential Cdc28p substrate; Swi6p 520353 SWI6 850879 SWI6 Saccharomyces cerevisiae Swi6p NP_013283.1 517942 D 4932 CDS NP_013284.1 6323212 850880 complement(520545..522014) 1 NC_001144.4 Transcription factor that binds to a number of promoter regions, particularly promoters of some genes involved in pheromone response and cell cycle; potential Cdc28p substrate; expression is induced in G1 by bound SBF; Tos4p 522014 TOS4 850880 TOS4 Saccharomyces cerevisiae Tos4p NP_013284.1 520545 R 4932 CDS NP_013286.1 6323214 850882 join(522665..522671,523031..523290) 1 NC_001144.4 Rpl37ap; Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Bp and to rat L37 ribosomal protein 523290 RPL37A 850882 RPL37A Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Bp and to rat L37 ribosomal protein NP_013286.1 522665 D 4932 CDS NP_013287.1 6323215 850883 523634..524392 1 NC_001144.4 Protein required for the maturation of the 18S rRNA and for 40S ribosome production; associated with spindle/microtubules; nuclear localization depends on physical interaction with Nop14p; may bind snoRNAs; Emg1p 524392 EMG1 850883 EMG1 Saccharomyces cerevisiae Emg1p NP_013287.1 523634 D 4932 CDS NP_013288.1 6323216 850884 524867..527947 1 NC_001144.4 Skg3p; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Caf120p and Skg4p 527947 SKG3 850884 SKG3 Saccharomyces cerevisiae Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Caf120p and Skg4p NP_013288.1 524867 D 4932 CDS NP_013289.1 6323217 850885 528302..530389 1 NC_001144.4 Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress; Mdl1p 530389 MDL1 850885 MDL1 Saccharomyces cerevisiae Mdl1p NP_013289.1 528302 D 4932 CDS NP_013290.1 6323218 850886 complement(530799..534395) 1 NC_001144.4 UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids, involved in autophagy; Atg26p 534395 ATG26 850886 ATG26 Saccharomyces cerevisiae Atg26p NP_013290.1 530799 R 4932 CDS NP_013291.1 6323219 850887 535216..536691 1 NC_001144.4 Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p; Mmr1p 536691 MMR1 850887 MMR1 Saccharomyces cerevisiae Mmr1p NP_013291.1 535216 D 4932 CDS NP_013292.1 6323220 850888 537274..538434 1 NC_001144.4 Pex13p; Integral peroxisomal membrane required for the translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p 538434 PEX13 850888 PEX13 Saccharomyces cerevisiae Integral peroxisomal membrane required for the translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p NP_013292.1 537274 D 4932 CDS NP_013293.1 6323221 850889 complement(538794..539591) 1 NC_001144.4 Hcr1p; Dual function protein involved in translation initiation as a substoichiometric component of eukaryotic translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA 539591 HCR1 850889 HCR1 Saccharomyces cerevisiae Dual function protein involved in translation initiation as a substoichiometric component of eukaryotic translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA NP_013293.1 538794 R 4932 CDS NP_013294.1 6323222 850890 complement(540011..540538) 1 NC_001144.4 Ups1p; Mitochondrial intermembrane space protein that regulates alternative processing and sorting of Mgm1p and other proteins; required for normal mitochondrial morphology; ortholog of human PRELI 540538 UPS1 850890 UPS1 Saccharomyces cerevisiae Mitochondrial intermembrane space protein that regulates alternative processing and sorting of Mgm1p and other proteins; required for normal mitochondrial morphology; ortholog of human PRELI NP_013294.1 540011 R 4932 CDS NP_013295.1 6323223 850891 complement(540811..541575) 1 NC_001144.4 Ylr194cp; Structural constituent of the cell wall attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress 541575 850891 YLR194C Saccharomyces cerevisiae Structural constituent of the cell wall attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress NP_013295.1 540811 R 4932 CDS NP_013296.1 6323224 850892 complement(541939..543306) 1 NC_001144.4 Nmt1p; N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction 543306 NMT1 850892 NMT1 Saccharomyces cerevisiae N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction NP_013296.1 541939 R 4932 CDS NP_013297.1 6323225 850893 543970..545700 1 NC_001144.4 Pwp1p; Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily 545700 PWP1 850893 PWP1 Saccharomyces cerevisiae Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily NP_013297.1 543970 D 4932 CDS NP_013298.1 6323226 850894 546099..547613 1 NC_001144.4 Sik1p; Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects 547613 SIK1 850894 SIK1 Saccharomyces cerevisiae Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects NP_013298.1 546099 D 4932 CDS NP_013300.2 37362679 850896 complement(join(547855..548679,548766..548771)) 1 NC_001144.4 Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly; Pba1p 548771 PBA1 850896 PBA1 Saccharomyces cerevisiae Pba1p NP_013300.2 547855 R 4932 CDS NP_013301.1 6323229 850897 549014..549358 1 NC_001144.4 Yke2p; Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin 549358 YKE2 850897 YKE2 Saccharomyces cerevisiae Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin NP_013301.1 549014 D 4932 CDS NP_013302.1 6323230 850898 complement(549513..550295) 1 NC_001144.4 Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; Coq9p 550295 COQ9 850898 COQ9 Saccharomyces cerevisiae Coq9p NP_013302.1 549513 R 4932 CDS NP_013304.1 6323232 850900 complement(550652..551962) 1 NC_001144.4 Nuclear encoded protein required for translation of COX1 mRNA; binds to Cox1 protein; Mss51p 551962 MSS51 850900 MSS51 Saccharomyces cerevisiae Mss51p NP_013304.1 550652 R 4932 CDS NP_013305.1 6323233 850901 552272..552607 1 NC_001144.4 Qri5p; Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA 552607 QRI5 850901 QRI5 Saccharomyces cerevisiae Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA NP_013305.1 552272 D 4932 CDS NP_013306.2 42742287 850902 complement(552726..553679) 1 NC_001144.4 Hmx1p; ER localized, heme-binding peroxidase involved in the degradation of heme; does not exhibit heme oxygenase activity despite similarity to heme oxygenases; expression regulated by AFT1 553679 HMX1 850902 HMX1 Saccharomyces cerevisiae ER localized, heme-binding peroxidase involved in the degradation of heme; does not exhibit heme oxygenase activity despite similarity to heme oxygenases; expression regulated by AFT1 NP_013306.2 552726 R 4932 CDS NP_013307.1 6323235 850903 554580..556421 1 NC_001144.4 Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus; Ent2p 556421 ENT2 850903 ENT2 Saccharomyces cerevisiae Ent2p NP_013307.1 554580 D 4932 CDS NP_013308.1 6323236 850904 556790..559291 1 NC_001144.4 Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD), forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events; Hrd3p 559291 HRD3 850904 HRD3 Saccharomyces cerevisiae Hrd3p NP_013308.1 556790 D 4932 CDS NP_013309.1 6323237 850905 559553..560446 1 NC_001144.4 Sec13p; Component of both the Nup84 nuclear pore sub-complex and of the COPII complex (Sar1p, Sec13p, Sec16p, Sec23p, Sec24p, Sec31p, Sfb2p, and Sfb3p) which is important for the formation of ER to Golgi transport vesicles 560446 SEC13 850905 SEC13 Saccharomyces cerevisiae Component of both the Nup84 nuclear pore sub-complex and of the COPII complex (Sar1p, Sec13p, Sec16p, Sec23p, Sec24p, Sec31p, Sfb2p, and Sfb3p) which is important for the formation of ER to Golgi transport vesicles NP_013309.1 559553 D 4932 CDS NP_013310.1 6323238 850906 complement(560799..561734) 1 NC_001144.4 Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway; Pnp1p 561734 PNP1 850906 PNP1 Saccharomyces cerevisiae Pnp1p NP_013310.1 560799 R 4932 CDS NP_013311.1 6323239 850907 562010..563392 1 NC_001144.4 Clb4p; B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation 563392 CLB4 850907 CLB4 Saccharomyces cerevisiae B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation NP_013311.1 562010 D 4932 CDS NP_013312.2 9755338 850908 complement(join(563794..564456,564516..564533)) 1 NC_001144.4 Ylr211cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron 564533 850908 YLR211C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron NP_013312.2 563794 R 4932 CDS NP_013313.1 6323241 850909 complement(564862..566283) 1 NC_001144.4 Tub4p; Gamma-tubulin, involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body 566283 TUB4 850909 TUB4 Saccharomyces cerevisiae Gamma-tubulin, involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body NP_013313.1 564862 R 4932 CDS NP_013314.1 6323242 850910 complement(566656..567924) 1 NC_001144.4 Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation; Crr1p 567924 CRR1 850910 CRR1 Saccharomyces cerevisiae Crr1p NP_013314.1 566656 R 4932 CDS NP_013315.1 6323243 850911 568569..570629 1 NC_001144.4 Fre1p; Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels 570629 FRE1 850911 FRE1 Saccharomyces cerevisiae Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels NP_013315.1 568569 D 4932 CDS NP_013316.1 6323244 850912 complement(570778..571860) 1 NC_001144.4 Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein; Cdc123p 571860 CDC123 850912 CDC123 Saccharomyces cerevisiae Cdc123p NP_013316.1 570778 R 4932 CDS NP_013317.1 6323246 850914 complement(572098..573213) 1 NC_001144.4 Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; Cpr6p 573213 CPR6 850914 CPR6 Saccharomyces cerevisiae Cpr6p NP_013317.1 572098 R 4932 CDS NP_013319.1 6323247 850915 complement(573468..573920) 1 NC_001144.4 Ylr218cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR218C is not essential; mutants exhibit glycogen storage defects and growth defects on a non-fermentable carbon source 573920 850915 YLR218C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR218C is not essential; mutants exhibit glycogen storage defects and growth defects on a non-fermentable carbon source NP_013319.1 573468 R 4932 CDS NP_013320.1 6323248 850916 574153..576339 1 NC_001144.4 Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate; Msc3p 576339 MSC3 850916 MSC3 Saccharomyces cerevisiae Msc3p NP_013320.1 574153 D 4932 CDS NP_013321.1 6323249 850917 576827..577795 1 NC_001144.4 Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; Ccc1p 577795 CCC1 850917 CCC1 Saccharomyces cerevisiae Ccc1p NP_013321.1 576827 D 4932 CDS NP_013322.1 6323250 850918 complement(578364..579026) 1 NC_001144.4 Rsa3p; Protein with a likely role in ribosomal maturation, required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus 579026 RSA3 850918 RSA3 Saccharomyces cerevisiae Protein with a likely role in ribosomal maturation, required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus NP_013322.1 578364 R 4932 CDS NP_013323.1 6323251 850919 complement(579320..581773) 1 NC_001144.4 Utp13p; Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA 581773 UTP13 850919 UTP13 Saccharomyces cerevisiae Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA NP_013323.1 579320 R 4932 CDS NP_013324.1 6323252 850920 complement(582235..585492) 1 NC_001144.4 Ifh1p; Essential protein with a highly acidic N-terminal domain; IFH1 exhibits genetic interactions with FHL1, overexpression interferes with silencing at telomeres and HM loci; potential Cdc28p substrate 585492 IFH1 850920 IFH1 Saccharomyces cerevisiae Essential protein with a highly acidic N-terminal domain; IFH1 exhibits genetic interactions with FHL1, overexpression interferes with silencing at telomeres and HM loci; potential Cdc28p substrate NP_013324.1 582235 R 4932 CDS NP_013325.1 6323253 850921 586466..587575 1 NC_001144.4 Ylr224wp; F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene 587575 850921 YLR224W Saccharomyces cerevisiae F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene NP_013325.1 586466 D 4932 CDS NP_013326.1 6323254 850922 complement(587697..588920) 1 NC_001144.4 Ylr225cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR225C is not an essential gene 588920 850922 YLR225C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR225C is not an essential gene NP_013326.1 587697 R 4932 CDS NP_013327.1 6323255 850923 589356..590543 1 NC_001144.4 Cyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II; Bur2p 590543 BUR2 850923 BUR2 Saccharomyces cerevisiae Bur2p NP_013327.1 589356 D 4932 CDS NP_013328.1 6323256 850924 complement(590564..592045) 1 NC_001144.4 Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; Ady4p 592045 ADY4 850924 ADY4 Saccharomyces cerevisiae Ady4p NP_013328.1 590564 R 4932 CDS NP_058171.1 7839187 850927 join(593440..594744,594746..598708) 1 NC_001144.4 Ylr227w-bp; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 598708 850927 YLR227W-B Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_058171.1 593440 D 4932 CDS NP_058172.1 7839186 850926 593440..594762 1 NC_001144.4 Ylr227w-ap; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 594762 850926 YLR227W-A Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_058172.1 593440 D 4932 CDS NP_013329.1 6323257 850928 complement(600021..602465) 1 NC_001144.4 Sterol regulatory element binding protein, regulates transcription of the sterol biosynthetic genes ERG2 and ERG3; member of the fungus-specific Zn[2]-Cys[6] binuclear cluster family of transcription factors; homologous to Upc2p; Ecm22p 602465 ECM22 850928 ECM22 Saccharomyces cerevisiae Ecm22p NP_013329.1 600021 R 4932 CDS NP_013330.1 6323259 850930 complement(604214..604789) 1 NC_001144.4 Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins; Cdc42p 604789 CDC42 850930 CDC42 Saccharomyces cerevisiae Cdc42p NP_013330.1 604214 R 4932 CDS NP_013332.1 6323261 850933 complement(605760..607121) 1 NC_001144.4 Kynureninase, required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway; Bna5p 607121 BNA5 850933 BNA5 Saccharomyces cerevisiae Bna5p NP_013332.1 605760 R 4932 CDS NP_013334.1 6323262 850934 complement(607427..609526) 1 NC_001144.4 TLC1 RNA-associated factor involved in telomere length regulation as the recruitment subunit of the telomerase holoenzyme, has a possible role in activating Est2p-TLC1-RNA bound to the telomere; Est1p 609526 EST1 850934 EST1 Saccharomyces cerevisiae Est1p NP_013334.1 607427 R 4932 CDS NP_013335.1 6323263 850935 609785..611755 1 NC_001144.4 Top3p; DNA Topoisomerase III, conserved protein that functions in a complex with Sgs1p and Rmi1p to relax single-stranded negatively-supercoiled DNA preferentially, involved in telomere stability and regulation of mitotic recombination 611755 TOP3 850935 TOP3 Saccharomyces cerevisiae DNA Topoisomerase III, conserved protein that functions in a complex with Sgs1p and Rmi1p to relax single-stranded negatively-supercoiled DNA preferentially, involved in telomere stability and regulation of mitotic recombination NP_013335.1 609785 D 4932 CDS NP_013338.1 6323266 850938 612369..614165 1 NC_001144.4 Thi7p; Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia 614165 THI7 850938 THI7 Saccharomyces cerevisiae Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia NP_013338.1 612369 D 4932 CDS NP_013339.1 6323267 850939 614757..616193 1 NC_001144.4 Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate; Far10p 616193 FAR10 850939 FAR10 Saccharomyces cerevisiae Far10p NP_013339.1 614757 D 4932 CDS NP_013340.1 6323268 850940 complement(616334..617320) 1 NC_001144.4 Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups; Lip2p 617320 LIP2 850940 LIP2 Saccharomyces cerevisiae Lip2p NP_013340.1 616334 R 4932 CDS NP_013341.1 6323269 850941 617535..620162 1 NC_001144.4 Vps34p; Phosphatidylinositol 3-kinase responsible for the synthesis of phosphatidylinositol 3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p 620162 VPS34 850941 VPS34 Saccharomyces cerevisiae Phosphatidylinositol 3-kinase responsible for the synthesis of phosphatidylinositol 3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p NP_013341.1 617535 D 4932 CDS NP_013342.1 6323270 850942 620475..622823 1 NC_001144.4 Ylr241wp; Putative protein of unknown function, may be involved in detoxification 622823 850942 YLR241W Saccharomyces cerevisiae Putative protein of unknown function, may be involved in detoxification NP_013342.1 620475 D 4932 CDS NP_013343.1 6323271 850943 complement(622920..623885) 1 NC_001144.4 Protein required for normal intracellular sterol distribution and for sphingolipid metabolism; similar to Nup120p and C. elegans R05H5.5 protein; Arv1p 623885 ARV1 850943 ARV1 Saccharomyces cerevisiae Arv1p NP_013343.1 622920 R 4932 CDS NP_013344.1 6323272 850944 624205..625023 1 NC_001144.4 Ylr243wp; Putative protein of unknown function; YLR243W is an essential gene 625023 850944 YLR243W Saccharomyces cerevisiae Putative protein of unknown function; YLR243W is an essential gene NP_013344.1 624205 D 4932 CDS NP_013345.1 6323273 850945 complement(625170..626333) 1 NC_001144.4 Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p; Map1p 626333 MAP1 850945 MAP1 Saccharomyces cerevisiae Map1p NP_013345.1 625170 R 4932 CDS NP_013346.1 6323274 850946 complement(626504..626932) 1 NC_001144.4 Cytidine deaminase; catalyzes the modification of cytidine to uridine in vitro but native RNA substrates have not been identified, localizes to both the nucleus and cytoplasm; Cdd1p 626932 CDD1 850946 CDD1 Saccharomyces cerevisiae Cdd1p NP_013346.1 626504 R 4932 CDS NP_013347.1 6323275 850947 627120..628199 1 NC_001144.4 Subunit of a palmitoyltransferase, composed of Erf2p and Shr5p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole; Erf2p 628199 ERF2 850947 ERF2 Saccharomyces cerevisiae Erf2p NP_013347.1 627120 D 4932 CDS NP_013348.1 6323276 850949 complement(628686..633356) 1 NC_001144.4 Putative helicase; localized to mitochondria and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52 foci; Irc20p 633356 IRC20 850949 IRC20 Saccharomyces cerevisiae Irc20p NP_013348.1 628686 R 4932 CDS NP_013349.1 6323277 850950 634254..636086 1 NC_001144.4 Rck2p; Protein kinase involved in the response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations 636086 RCK2 850950 RCK2 Saccharomyces cerevisiae Protein kinase involved in the response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations NP_013349.1 634254 D 4932 CDS NP_013350.1 6323278 850951 636782..639916 1 NC_001144.4 Yef3p; Translational elongation factor 3, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing EF-1 alpha from the ribosomal complex; contains two ABC cassettes; binds and hydrolyses ATP 639916 YEF3 850951 YEF3 Saccharomyces cerevisiae Translational elongation factor 3, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing EF-1 alpha from the ribosomal complex; contains two ABC cassettes; binds and hydrolyses ATP NP_013350.1 636782 D 4932 CDS NP_013351.1 6323279 850952 640319..641023 1 NC_001144.4 Ssp120p; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 641023 SSP120 850952 SSP120 Saccharomyces cerevisiae Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern NP_013351.1 640319 D 4932 CDS NP_013352.1 6323280 850953 641466..642059 1 NC_001144.4 Sym1p; Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17 642059 SYM1 850953 SYM1 Saccharomyces cerevisiae Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17 NP_013352.1 641466 D 4932 CDS NP_013354.1 6323282 850955 642629..644338 1 NC_001144.4 Ylr253wp; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; transcription is periodic during the metabolic cycle; YLR253W is not an essential gene 644338 850955 YLR253W Saccharomyces cerevisiae Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; transcription is periodic during the metabolic cycle; YLR253W is not an essential gene NP_013354.1 642629 D 4932 CDS NP_013355.1 6323283 850956 complement(644406..644975) 1 NC_001144.4 Ndl1p; Homolog of nuclear distribution factor NudE, NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends 644975 NDL1 850956 NDL1 Saccharomyces cerevisiae Homolog of nuclear distribution factor NudE, NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends NP_013355.1 644406 R 4932 CDS NP_013357.1 6323285 850958 646417..650925 1 NC_001144.4 Zinc finger transcription factor involved in the complex regulation of gene expression in response to levels of heme and oxygen; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus; Hap1p 650925 HAP1 850958 HAP1 Saccharomyces cerevisiae Hap1p NP_013357.1 646417 D 4932 CDS NP_058173.1 7839188 850959 651119..652441 1 NC_001144.4 Ylr256w-ap; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 652441 850959 YLR256W-A Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_058173.1 651119 D 4932 CDS NP_013358.1 6323286 850961 658828..659793 1 NC_001144.4 Ylr257wp; Putative protein of unknown function 659793 850961 YLR257W Saccharomyces cerevisiae Putative protein of unknown function NP_013358.1 658828 D 4932 CDS NP_013359.1 6323287 850962 660718..662835 1 NC_001144.4 Gsy2p; Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase 662835 GSY2 850962 GSY2 Saccharomyces cerevisiae Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase NP_013359.1 660718 D 4932 CDS NP_013360.1 6323288 850963 complement(663286..665004) 1 NC_001144.4 Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated; Hsp60p 665004 HSP60 850963 HSP60 Saccharomyces cerevisiae Hsp60p NP_013360.1 663286 R 4932 CDS NP_013361.1 6323289 850964 665846..667909 1 NC_001144.4 Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules; Lcb5p 667909 LCB5 850964 LCB5 Saccharomyces cerevisiae Lcb5p NP_013361.1 665846 D 4932 CDS NP_013363.1 6323291 850966 complement(668246..668893) 1 NC_001144.4 Ypt6p; GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6 668893 YPT6 850966 YPT6 Saccharomyces cerevisiae GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6 NP_013363.1 668246 R 4932 CDS NP_013364.1 6323292 850967 complement(669470..669664) 1 NC_001144.4 Tma7p; Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin 669664 TMA7 850967 TMA7 Saccharomyces cerevisiae Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin NP_013364.1 669470 R 4932 CDS NP_013365.1 6323293 850968 670342..672825 1 NC_001144.4 Red1p; Protein component of the axial elements of the synaptonemal complex, involved in chromosome segregation during the first meiotic division; interacts with Hop1p; required for wild-type levels of Mek1p kinase activity 672825 RED1 850968 RED1 Saccharomyces cerevisiae Protein component of the axial elements of the synaptonemal complex, involved in chromosome segregation during the first meiotic division; interacts with Hop1p; required for wild-type levels of Mek1p kinase activity NP_013365.1 670342 D 4932 CDS NP_013366.1 6323294 850969 673133..673336 1 NC_001144.4 Rps28bp; Protein component of the small (40S) ribosomal subunit; nearly identical to Rps28Ap and has similarity to rat S28 ribosomal protein 673336 RPS28B 850969 RPS28B Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit; nearly identical to Rps28Ap and has similarity to rat S28 ribosomal protein NP_013366.1 673133 D 4932 CDS NP_878129.1 33438841 1466417 complement(673830..673946) 1 NC_001144.4 Ylr264c-ap; Putative protein of unknown function 673946 1466417 YLR264C-A Saccharomyces cerevisiae Putative protein of unknown function NP_878129.1 673830 R 4932 CDS NP_013367.1 6323295 850970 complement(674429..675457) 1 NC_001144.4 Protein involved in regulation of nonhomologous end joining; interacts with DNA ligase IV components Dnl4p and Lif1p; repressed by MAT heterozygosity; regulates cellular distribution of Lif1p; Nej1p 675457 NEJ1 850970 NEJ1 Saccharomyces cerevisiae Nej1p NP_013367.1 674429 R 4932 CDS NP_013368.1 6323296 850971 complement(675621..677726) 1 NC_001144.4 Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon; Pdr8p 677726 PDR8 850971 PDR8 Saccharomyces cerevisiae Pdr8p NP_013368.1 675621 R 4932 CDS NP_013369.1 6323297 850972 678214..679926 1 NC_001144.4 Protein of unknown function, overproduction suppresses a pam1 slv3 double null mutation; Bop2p 679926 BOP2 850972 BOP2 Saccharomyces cerevisiae Bop2p NP_013369.1 678214 D 4932 CDS NP_013370.1 6323298 850973 680202..680846 1 NC_001144.4 Sec22p; R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog 680846 SEC22 850973 SEC22 Saccharomyces cerevisiae R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog NP_013370.1 680202 D 4932 CDS NP_013372.1 6323299 850974 681188..682240 1 NC_001144.4 Non-essential hydrolase involved in mRNA decapping, may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; interacts with neutral trehalase Nth1p; Dcs1p 682240 DCS1 850974 DCS1 Saccharomyces cerevisiae Dcs1p NP_013372.1 681188 D 4932 CDS NP_013373.1 6323301 850976 682739..683563 1 NC_001144.4 Ylr271wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS 683563 850976 YLR271W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS NP_013373.1 682739 D 4932 CDS NP_013374.1 6323302 850977 complement(683674..687204) 1 NC_001144.4 Ycs4p; Non-SMC subunit of the condensin complex (Smc2p-Smc4p-Ycs4p-Brn1p-Ycg1p); required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin and silencing at the mating type locus 687204 YCS4 850977 YCS4 Saccharomyces cerevisiae Non-SMC subunit of the condensin complex (Smc2p-Smc4p-Ycs4p-Brn1p-Ycg1p); required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin and silencing at the mating type locus NP_013374.1 683674 R 4932 CDS NP_013375.1 6323303 850979 complement(689085..691031) 1 NC_001144.4 Putative targeting subunit for the type-1 protein phosphatase Glc7p that tethers it to the Gsy2p glycogen synthase; Pig1p 691031 PIG1 850979 PIG1 Saccharomyces cerevisiae Pig1p NP_013375.1 689085 R 4932 CDS NP_013376.1 6323304 850980 691557..693884 1 NC_001144.4 Mcm5p; Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase 693884 MCM5 850980 MCM5 Saccharomyces cerevisiae Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase NP_013376.1 691557 D 4932 CDS NP_013377.1 6323305 850981 join(694380..694384,694475..694802) 1 NC_001144.4 Smd2p; Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2 694802 SMD2 850981 SMD2 Saccharomyces cerevisiae Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2 NP_013377.1 694380 D 4932 CDS NP_013378.1 6323306 850982 complement(695048..696832) 1 NC_001144.4 Dbp9p; ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 60S ribosomal subunit 696832 DBP9 850982 DBP9 Saccharomyces cerevisiae ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 60S ribosomal subunit NP_013378.1 695048 R 4932 CDS NP_013379.1 6323307 850983 complement(697158..699497) 1 NC_001144.4 Ysh1p; Putative endoribonuclease, subunit of the mRNA cleavage and polyadenylation specificity complex required for 3' processing of mRNAs 699497 YSH1 850983 YSH1 Saccharomyces cerevisiae Putative endoribonuclease, subunit of the mRNA cleavage and polyadenylation specificity complex required for 3' processing of mRNAs NP_013379.1 697158 R 4932 CDS NP_013380.1 6323308 850984 complement(700001..704026) 1 NC_001144.4 Zinc-cluster protein; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; YLR278C is not an essential gene; Ylr278cp 704026 850984 YLR278C Saccharomyces cerevisiae Ylr278cp NP_013380.1 700001 R 4932 CDS NP_013383.1 6323311 850987 complement(704495..704962) 1 NC_001144.4 Ylr281cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene 704962 850987 YLR281C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene NP_013383.1 704495 R 4932 CDS NP_013385.1 6323312 850988 705188..706132 1 NC_001144.4 Ylr283wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene 706132 850988 YLR283W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene NP_013385.1 705188 D 4932 CDS NP_013386.1 6323314 850990 complement(706200..707042) 1 NC_001144.4 Peroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced; Eci1p 707042 ECI1 850990 ECI1 Saccharomyces cerevisiae Eci1p NP_013386.1 706200 R 4932 CDS NP_013387.1 6323315 850991 707362..708147 1 NC_001144.4 Putative nicotinamide N-methyltransferase, has a role in rDNA silencing and in lifespan determination; Nnt1p 708147 NNT1 850991 NNT1 Saccharomyces cerevisiae Nnt1p NP_013387.1 707362 D 4932 CDS NP_878130.1 33438842 1466418 complement(708170..708340) 1 NC_001144.4 Ylr285c-ap; Putative protein of unknown function; identified by fungal homology and RT-PCR 708340 1466418 YLR285C-A Saccharomyces cerevisiae Putative protein of unknown function; identified by fungal homology and RT-PCR NP_878130.1 708170 R 4932 CDS NP_013388.1 6323316 850992 complement(708450..710138) 1 NC_001144.4 Endochitinase, required for cell separation after mitosis; transcriptional activation during late G and early M cell cycle phases is mediated by transcription factor Ace2p; Cts1p 710138 CTS1 850992 CTS1 Saccharomyces cerevisiae Cts1p NP_013388.1 708450 R 4932 CDS NP_013389.1 6323317 850993 complement(710993..712060) 1 NC_001144.4 Ylr287cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene 712060 850993 YLR287C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene NP_013389.1 710993 R 4932 CDS NP_013390.1 6323318 850994 complement(join(712539..712727,713158..713160)) 1 NC_001144.4 Rps30ap; Protein component of the small (40S) ribosomal subunit; nearly identical to Rps30Bp and has similarity to rat S30 ribosomal protein 713160 RPS30A 850994 RPS30A Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit; nearly identical to Rps30Bp and has similarity to rat S30 ribosomal protein NP_013390.1 712539 R 4932 CDS NP_013391.1 6323319 850995 complement(713482..714906) 1 NC_001144.4 Mec3p; DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1 714906 MEC3 850995 MEC3 Saccharomyces cerevisiae DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1 NP_013391.1 713482 R 4932 CDS NP_013392.1 6323320 850996 715091..717028 1 NC_001144.4 Mitochondrial GTPase of unknown function, similar to E. coli elongation factor-type GTP-binding protein LepA and to LK1236.1 from Caenorhabditis elegans; Guf1p 717028 GUF1 850996 GUF1 Saccharomyces cerevisiae Guf1p NP_013392.1 715091 D 4932 CDS NP_013393.1 6323321 850997 complement(717147..717980) 1 NC_001144.4 Ylr290cp; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR290C is not an essential gene 717980 850997 YLR290C Saccharomyces cerevisiae Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR290C is not an essential gene NP_013393.1 717147 R 4932 CDS NP_013394.1 6323322 850998 complement(718319..719464) 1 NC_001144.4 Gcd7p; Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression 719464 GCD7 850998 GCD7 Saccharomyces cerevisiae Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression NP_013394.1 718319 R 4932 CDS NP_013395.1 6323323 850999 complement(719791..720372) 1 NC_001144.4 Sec72p; Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER 720372 SEC72 850999 SEC72 Saccharomyces cerevisiae Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER NP_013395.1 719791 R 4932 CDS NP_013396.1 6323324 851000 complement(720773..721432) 1 NC_001144.4 Gsp1p; GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; regulated by Prp20p, Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p and Kap95p; yeast Gsp2p homolog 721432 GSP1 851000 GSP1 Saccharomyces cerevisiae GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; regulated by Prp20p, Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p and Kap95p; yeast Gsp2p homolog NP_013396.1 720773 R 4932 CDS NP_013398.1 6323326 851002 complement(722001..722375) 1 NC_001144.4 Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; Atp14p 722375 ATP14 851002 ATP14 Saccharomyces cerevisiae Atp14p NP_013398.1 722001 R 4932 CDS NP_013400.1 6323328 851004 724046..724435 1 NC_001144.4 Ylr297wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YLR297W is not an essential gene 724435 851004 YLR297W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YLR297W is not an essential gene NP_013400.1 724046 D 4932 CDS NP_013401.1 6323329 851005 complement(724723..725418) 1 NC_001144.4 Yhc1p; Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site 725418 YHC1 851005 YHC1 Saccharomyces cerevisiae Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site NP_013401.1 724723 R 4932 CDS NP_013402.1 6323330 851006 726071..728053 1 NC_001144.4 Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation; Ecm38p 728053 ECM38 851006 ECM38 Saccharomyces cerevisiae Ecm38p NP_013402.1 726071 D 4932 CDS NP_013403.1 6323331 851007 728957..730303 1 NC_001144.4 Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes; Exg1p 730303 EXG1 851007 EXG1 Saccharomyces cerevisiae Exg1p NP_013403.1 728957 D 4932 CDS NP_013404.1 6323332 851008 730827..731561 1 NC_001144.4 Ylr301wp; Protein of unknown function that interacts with Sec72p 731561 851008 YLR301W Saccharomyces cerevisiae Protein of unknown function that interacts with Sec72p NP_013404.1 730827 D 4932 CDS NP_013406.1 6323333 851010 732544..733878 1 NC_001144.4 Methionine and cysteine synthase (O-acetyl homoserine-O-acetyl serine sulfhydrylase), required for sulfur amino acid synthesis; Met17p 733878 MET17 851010 MET17 Saccharomyces cerevisiae Met17p NP_013406.1 732544 D 4932 CDS NP_013407.1 6323335 851013 complement(735214..737550) 1 NC_001144.4 Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy; Aco1p 737550 ACO1 851013 ACO1 Saccharomyces cerevisiae Aco1p NP_013407.1 735214 R 4932 CDS NP_013408.1 6323336 851014 complement(738163..743865) 1 NC_001144.4 Stt4p; Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization 743865 STT4 851014 STT4 Saccharomyces cerevisiae Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization NP_013408.1 738163 R 4932 CDS NP_013409.1 6323337 851015 join(744153..744155,744290..744853) 1 NC_001144.4 Ubc12p; Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes 744853 UBC12 851015 UBC12 Saccharomyces cerevisiae Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes NP_013409.1 744153 D 4932 CDS NP_013410.1 6323338 851016 745622..746527 1 NC_001144.4 Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall; Cda1p 746527 CDA1 851016 CDA1 Saccharomyces cerevisiae Cda1p NP_013410.1 745622 D 4932 CDS NP_878131.1 33438843 1466419 complement(746850..747113) 1 NC_001144.4 Ylr307c-ap; Putative protein of unknown function 747113 1466419 YLR307C-A Saccharomyces cerevisiae Putative protein of unknown function NP_878131.1 746850 R 4932 CDS NP_013411.1 6323339 851017 747939..748877 1 NC_001144.4 Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall; Cda2p 748877 CDA2 851017 CDA2 Saccharomyces cerevisiae Cda2p NP_013411.1 747939 D 4932 CDS NP_013412.1 6323340 851018 complement(749036..751771) 1 NC_001144.4 Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi; Imh1p 751771 IMH1 851018 IMH1 Saccharomyces cerevisiae Imh1p NP_013412.1 749036 R 4932 CDS NP_013413.1 6323341 851019 complement(752226..756995) 1 NC_001144.4 Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1; Cdc25p 756995 CDC25 851019 CDC25 Saccharomyces cerevisiae Cdc25p NP_013413.1 752226 R 4932 CDS NP_013415.1 6323343 851021 complement(757639..758835) 1 NC_001144.4 Qnq1p; Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity 758835 QNQ1 851021 QNQ1 Saccharomyces cerevisiae Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity NP_013415.1 757639 R 4932 CDS NP_013416.2 116006497 851022 759482..760243 1 NC_001144.4 Mrpl15p; Mitochondrial ribosomal protein of the large subunit 760243 MRPL15 851022 MRPL15 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit NP_013416.2 759482 D 4932 CDS NP_013417.2 42742288 851023 complement(760357..762342) 1 NC_001144.4 Sph1p; Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p 762342 SPH1 851023 SPH1 Saccharomyces cerevisiae Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p NP_013417.2 760357 R 4932 CDS NP_013418.1 6323346 851024 complement(762575..764137) 1 NC_001144.4 Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM; Cdc3p 764137 CDC3 851024 CDC3 Saccharomyces cerevisiae Cdc3p NP_013418.1 762575 R 4932 CDS NP_013419.1 6323347 851025 764808..765269 1 NC_001144.4 Non-essential kinetochore protein, subunit of the Ctf19 central kinetochore complex (Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p- Nkp1p-Nkp2p-Ame1p-Mtw1p); Nkp2p 765269 NKP2 851025 NKP2 Saccharomyces cerevisiae Nkp2p NP_013419.1 764808 D 4932 CDS NP_013420.2 9755339 851027 complement(join(765266..766073,766130..766181,766250..766358)) 1 NC_001144.4 Tad3p; Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs 766358 TAD3 851027 TAD3 Saccharomyces cerevisiae Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs NP_013420.2 765266 R 4932 CDS NP_013422.1 6323350 851028 766542..769196 1 NC_001144.4 Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia; Est2p 769196 EST2 851028 EST2 Saccharomyces cerevisiae Est2p NP_013422.1 766542 D 4932 CDS NP_013423.1 6323351 851029 complement(769318..771684) 1 NC_001144.4 Bud6p; Actin- and formin-interacting protein, involved in actin cable nucleation and polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate 771684 BUD6 851029 BUD6 Saccharomyces cerevisiae Actin- and formin-interacting protein, involved in actin cable nucleation and polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate NP_013423.1 769318 R 4932 CDS NP_013424.1 6323352 851030 771940..776304 1 NC_001144.4 Protein involved in resistance to ionizing radiation; acts with Mms1p in a repair pathway that may be involved in resolving replication intermediates or preventing the damage caused by blocked replication forks; Mms22p 776304 MMS22 851030 MMS22 Saccharomyces cerevisiae Mms22p NP_013424.1 771940 D 4932 CDS NP_013425.1 6323354 851032 complement(776584..777864) 1 NC_001144.4 Sfh1p; Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progressionand maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog 777864 SFH1 851032 SFH1 Saccharomyces cerevisiae Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progressionand maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog NP_013425.1 776584 R 4932 CDS NP_013427.1 6323355 851033 complement(778173..778952) 1 NC_001144.4 Essential protein, component of a complex containing Cef1p; has similarity to S. pombe Cwf24p; Cwc24p 778952 CWC24 851033 CWC24 Saccharomyces cerevisiae Cwc24p NP_013427.1 778173 R 4932 CDS NP_013428.1 6323356 851034 779215..780786 1 NC_001144.4 Pex30p; Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p 780786 PEX30 851034 PEX30 Saccharomyces cerevisiae Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p NP_013428.1 779215 D 4932 CDS NP_013429.1 6323357 851035 complement(781143..781379) 1 NC_001144.4 Rpl38p; Protein component of the large (60S) ribosomal subunit, has similarity to rat L38 ribosomal protein 781379 RPL38 851035 RPL38 Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, has similarity to rat L38 ribosomal protein NP_013429.1 781143 R 4932 CDS NP_013430.1 6323358 851036 782174..782896 1 NC_001144.4 Ylr326wp 782896 851036 YLR326W Saccharomyces cerevisiae Ylr326wp NP_013430.1 782174 D 4932 CDS NP_013431.1 6323359 851037 complement(783127..783387) 1 NC_001144.4 Tma10p; Protein of unknown function that associates with ribosomes 783387 TMA10 851037 TMA10 Saccharomyces cerevisiae Protein of unknown function that associates with ribosomes NP_013431.1 783127 R 4932 CDS NP_013432.1 6323360 851039 784913..786118 1 NC_001144.4 Nma1p; Nicotinic acid mononucleotide adenylyltransferase, involved in NAD(+) salvage pathway 786118 NMA1 851039 NMA1 Saccharomyces cerevisiae Nicotinic acid mononucleotide adenylyltransferase, involved in NAD(+) salvage pathway NP_013432.1 784913 D 4932 CDS NP_013433.2 85666120 851040 join(786442..786615,786713..787333) 1 NC_001144.4 Rec102p; Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination 787333 REC102 851040 REC102 Saccharomyces cerevisiae Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination NP_013433.2 786442 D 4932 CDS NP_013434.1 6323362 851041 787664..789679 1 NC_001144.4 Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane; Chs5p 789679 CHS5 851041 CHS5 Saccharomyces cerevisiae Chs5p NP_013434.1 787664 D 4932 CDS NP_013436.1 6323363 851042 790676..791806 1 NC_001144.4 O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p; Mid2p 791806 MID2 851042 MID2 Saccharomyces cerevisiae Mid2p NP_013436.1 790676 D 4932 CDS NP_013437.1 6323365 851045 complement(795573..795899) 1 NC_001144.4 Rps25bp; Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Ap and has similarity to rat S25 ribosomal protein 795899 RPS25B 851045 RPS25B Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Ap and has similarity to rat S25 ribosomal protein NP_013437.1 795573 R 4932 CDS NP_013439.1 6323367 851048 797430..799592 1 NC_001144.4 Nup2p; Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization 799592 NUP2 851048 NUP2 Saccharomyces cerevisiae Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization NP_013439.1 797430 D 4932 CDS NP_013440.1 6323368 851049 complement(799697..802396) 1 NC_001144.4 Sgd1p; Essential nuclear protein with a possible role in the osmoregulatory glycerol response; interacts with phospholipase C (Plc1p); putative homolog of human NOM1 which is implicated in acute myeloid leukemia 802396 SGD1 851049 SGD1 Saccharomyces cerevisiae Essential nuclear protein with a possible role in the osmoregulatory glycerol response; interacts with phospholipase C (Plc1p); putative homolog of human NOM1 which is implicated in acute myeloid leukemia NP_013440.1 799697 R 4932 CDS NP_013441.1 6323370 851051 complement(802653..805106) 1 NC_001144.4 Vrp1p; Proline-rich actin-associated protein involved in cytoskeletal organization and cytokinesis; related to mammalian Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP) 805106 VRP1 851051 VRP1 Saccharomyces cerevisiae Proline-rich actin-associated protein involved in cytoskeletal organization and cytokinesis; related to mammalian Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP) NP_013441.1 802653 R 4932 CDS NP_013444.1 6323371 851052 805887..806825 1 NC_001144.4 Rpp0p; Conserved ribosomal protein P0 similar to rat P0, human P0, and E. coli L10e; shown to be phosphorylated on serine 302 806825 RPP0 851052 RPP0 Saccharomyces cerevisiae Conserved ribosomal protein P0 similar to rat P0, human P0, and E. coli L10e; shown to be phosphorylated on serine 302 NP_013444.1 805887 D 4932 CDS NP_013445.1 6323373 851054 807385..808818 1 NC_001144.4 Spo77p; Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis 808818 SPO77 851054 SPO77 Saccharomyces cerevisiae Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis NP_013445.1 807385 D 4932 CDS NP_013446.1 6323374 851055 809997..815627 1 NC_001144.4 Fks1p; Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling 815627 FKS1 851055 FKS1 Saccharomyces cerevisiae Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling NP_013446.1 809997 D 4932 CDS NP_878133.1 33438845 1466421 815810..815983 1 NC_001144.4 Ylr342w-ap; Putative protein of unknown function 815983 1466421 YLR342W-A Saccharomyces cerevisiae Putative protein of unknown function NP_878133.1 815810 D 4932 CDS NP_013447.1 6323375 851056 816094..817761 1 NC_001144.4 Gas2p; 1,3-beta-glucanosyltransferase, involved with Gas4p in spore wall assembly; has similarity to Gas1p 817761 GAS2 851056 GAS2 Saccharomyces cerevisiae 1,3-beta-glucanosyltransferase, involved with Gas4p in spore wall assembly; has similarity to Gas1p NP_013447.1 816094 D 4932 CDS NP_013448.1 6323376 851058 join(819312..819330,819778..820142) 1 NC_001144.4 Rpl26ap; Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Bp and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA 820142 RPL26A 851058 RPL26A Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Bp and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA NP_013448.1 819312 D 4932 CDS NP_013449.1 6323377 851059 820511..822040 1 NC_001144.4 Ylr345wp; Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene 822040 851059 YLR345W Saccharomyces cerevisiae Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene NP_013449.1 820511 D 4932 CDS NP_013450.1 6323378 851060 complement(822287..822592) 1 NC_001144.4 Ylr346cp; Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene 822592 851060 YLR346C Saccharomyces cerevisiae Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene NP_013450.1 822287 R 4932 CDS NP_013451.1 6323379 851061 complement(823827..826412) 1 NC_001144.4 Karyopherin beta, forms a dimeric complex with Srp1p (Kap60p) that mediates nuclear import of cargo proteins via a nuclear localization signal (NLS), interacts with nucleoporins to guide transport across the nuclear pore complex; Kap95p 826412 KAP95 851061 KAP95 Saccharomyces cerevisiae Kap95p NP_013451.1 823827 R 4932 CDS NP_013452.1 6323381 851063 complement(826976..827872) 1 NC_001144.4 Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix; Dic1p 827872 DIC1 851063 DIC1 Saccharomyces cerevisiae Dic1p NP_013452.1 826976 R 4932 CDS NP_013454.1 6323382 851064 828729..829379 1 NC_001144.4 Orm2p; Evolutionarily conserved protein with similarity to Orm1p, required for resistance to agents that induce the unfolded protein response; human ortholog is located in the endoplasmic reticulum 829379 ORM2 851064 ORM2 Saccharomyces cerevisiae Evolutionarily conserved protein with similarity to Orm1p, required for resistance to agents that induce the unfolded protein response; human ortholog is located in the endoplasmic reticulum NP_013454.1 828729 D 4932 CDS NP_013455.1 6323383 851065 complement(829488..830363) 1 NC_001144.4 Nit3p; Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member 830363 NIT3 851065 NIT3 Saccharomyces cerevisiae Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member NP_013455.1 829488 R 4932 CDS NP_013456.1 6323384 851066 831115..833538 1 NC_001144.4 Ylr352wp; Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene 833538 851066 YLR352W Saccharomyces cerevisiae Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene NP_013456.1 831115 D 4932 CDS NP_013457.1 6323385 851067 834351..836162 1 NC_001144.4 Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole; Bud8p 836162 BUD8 851067 BUD8 Saccharomyces cerevisiae Bud8p NP_013457.1 834351 D 4932 CDS NP_013458.1 6323386 851068 complement(836349..837356) 1 NC_001144.4 Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate; Tal1p 837356 TAL1 851068 TAL1 Saccharomyces cerevisiae Tal1p NP_013458.1 836349 R 4932 CDS NP_013459.1 6323387 851069 complement(838065..839252) 1 NC_001144.4 Ilv5p; Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosynthesis, also required for maintenance of wild-type mitochondrial DNA and found in mitochondrial nucleoids 839252 ILV5 851069 ILV5 Saccharomyces cerevisiae Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosynthesis, also required for maintenance of wild-type mitochondrial DNA and found in mitochondrial nucleoids NP_013459.1 838065 R 4932 CDS NP_013460.1 6323388 851070 840320..840913 1 NC_001144.4 Ylr356wp; Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene 840913 851070 YLR356W Saccharomyces cerevisiae Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene NP_013460.1 840320 D 4932 CDS NP_013461.1 6323389 851071 841330..843999 1 NC_001144.4 Rsc2p; Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance 843999 RSC2 851071 RSC2 Saccharomyces cerevisiae Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance NP_013461.1 841330 D 4932 CDS NP_013463.1 6323391 851073 844281..845729 1 NC_001144.4 Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency; Ade13p 845729 ADE13 851073 ADE13 Saccharomyces cerevisiae Ade13p NP_013463.1 844281 D 4932 CDS NP_013464.1 6323392 851074 846102..847421 1 NC_001144.4 Vps38p; Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity 847421 VPS38 851074 VPS38 Saccharomyces cerevisiae Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity NP_013464.1 846102 D 4932 CDS NP_013465.1 6323393 851075 complement(847387..849123) 1 NC_001144.4 Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START; Dcr2p 849123 DCR2 851075 DCR2 Saccharomyces cerevisiae Dcr2p NP_013465.1 847387 R 4932 CDS NP_878134.1 33438846 1466422 complement(849382..849678) 1 NC_001144.4 Ylr361c-ap; Putative protein of unknown function 849678 1466422 YLR361C-A Saccharomyces cerevisiae Putative protein of unknown function NP_878134.1 849382 R 4932 CDS NP_013466.1 6323394 851076 849865..852018 1 NC_001144.4 Ste11p; Signal transducing MEK kinase involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p 852018 STE11 851076 STE11 Saccharomyces cerevisiae Signal transducing MEK kinase involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p NP_013466.1 849865 D 4932 CDS NP_013467.1 6323395 851077 complement(852494..853150) 1 NC_001144.4 Protein interacting with Nam7p, may be involved in the nonsense-mediated mRNA decay pathway; Nmd4p 853150 NMD4 851077 NMD4 Saccharomyces cerevisiae Nmd4p NP_013467.1 852494 R 4932 CDS NP_076903.1 13129181 851078 853460..853717 1 NC_001144.4 Ylr363w-ap; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus 853717 851078 YLR363W-A Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus NP_076903.1 853460 D 4932 CDS NP_013468.1 6323396 851079 854061..854390 1 NC_001144.4 Ylr364wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR364W is not an essential gene 854390 851079 YLR364W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR364W is not an essential gene NP_013468.1 854061 D 4932 CDS NP_013471.1 6323399 851082 join(856441..856573,857057..857316) 1 NC_001144.4 Rps22bp; Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Ap and has similarity to E. coli S8 and rat S15a ribosomal proteins 857316 RPS22B 851082 RPS22B Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Ap and has similarity to E. coli S8 and rat S15a ribosomal proteins NP_013471.1 856441 D 4932 CDS NP_013472.1 6323400 851083 857539..859335 1 NC_001144.4 Mdm30p; F-box protein; physically associates with mitochondria and is required for normal mitochondrial fusion in rich medium, during sporulation, and in mating cells; promotes ubiquitin-mediated degradation of Gal4p in some strains 859335 MDM30 851083 MDM30 Saccharomyces cerevisiae F-box protein; physically associates with mitochondria and is required for normal mitochondrial fusion in rich medium, during sporulation, and in mating cells; promotes ubiquitin-mediated degradation of Gal4p in some strains NP_013472.1 857539 D 4932 CDS NP_013473.1 6323401 851084 859551..861524 1 NC_001144.4 Ssq1p; Mitochondrial hsp70-type molecular chaperone, required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia 861524 SSQ1 851084 SSQ1 Saccharomyces cerevisiae Mitochondrial hsp70-type molecular chaperone, required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia NP_013473.1 859551 D 4932 CDS NP_013474.1 6323402 851085 complement(861717..862253) 1 NC_001144.4 Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; Arc18p 862253 ARC18 851085 ARC18 Saccharomyces cerevisiae Arc18p NP_013474.1 861717 R 4932 CDS NP_013475.1 6323403 851086 862713..866783 1 NC_001144.4 Rom2p; GDP/GTP exchange protein (GEP) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEP 866783 ROM2 851086 ROM2 Saccharomyces cerevisiae GDP/GTP exchange protein (GEP) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEP NP_013475.1 862713 D 4932 CDS NP_013476.1 6323404 851087 867353..868390 1 NC_001144.4 Sur4p; Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis 868390 SUR4 851087 SUR4 Saccharomyces cerevisiae Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis NP_013476.1 867353 D 4932 CDS NP_013477.1 6323405 851088 complement(868661..871366) 1 NC_001144.4 Vid22p; Glycosylated integral membrane protein localized to the plasma membrane; plays a role in fructose-1,6-bisphosphatase (FBPase) degradation; involved in FBPase transport from the cytosol to Vid (vacuole import and degradation) vesicles 871366 VID22 851088 VID22 Saccharomyces cerevisiae Glycosylated integral membrane protein localized to the plasma membrane; plays a role in fructose-1,6-bisphosphatase (FBPase) degradation; involved in FBPase transport from the cytosol to Vid (vacuole import and degradation) vesicles NP_013477.1 868661 R 4932 CDS NP_013479.1 6323406 851089 871696..872727 1 NC_001144.4 Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids; Stp3p 872727 STP3 851089 STP3 Saccharomyces cerevisiae Stp3p NP_013479.1 871696 D 4932 CDS NP_013480.1 6323408 851091 complement(872825..873553) 1 NC_001144.4 Psy3p; Protein of unknown function; deletion results in a mutator phenotype suggesting a role for this protein as a mutational suppressor; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C 873553 PSY3 851091 PSY3 Saccharomyces cerevisiae Protein of unknown function; deletion results in a mutator phenotype suggesting a role for this protein as a mutational suppressor; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C NP_013480.1 872825 R 4932 CDS NP_013481.1 6323409 851092 complement(873745..874791) 1 NC_001144.4 Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; Fbp1p 874791 FBP1 851092 FBP1 Saccharomyces cerevisiae Fbp1p NP_013481.1 873745 R 4932 CDS NP_013482.1 6323411 851095 complement(875735..877177) 1 NC_001144.4 Sec61p; Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER 877177 SEC61 851095 SEC61 Saccharomyces cerevisiae Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER NP_013482.1 875735 R 4932 CDS NP_013484.1 6323412 851096 878282..879508 1 NC_001144.4 Phosphatidylinositol transfer protein with a potential role in lipid turnover; interacts specifically with thioredoxin peroxidase (Tsa2p) and may have a role in oxidative stress resistance; Csr1p 879508 CSR1 851096 CSR1 Saccharomyces cerevisiae Csr1p NP_013484.1 878282 D 4932 CDS NP_013485.1 6323413 851097 879723..881924 1 NC_001144.4 Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules; Ctf3p 881924 CTF3 851097 CTF3 Saccharomyces cerevisiae Ctf3p NP_013485.1 879723 D 4932 CDS NP_013486.1 6323414 851098 complement(882067..884751) 1 NC_001144.4 Nam2p; Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance 884751 NAM2 851098 NAM2 Saccharomyces cerevisiae Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance NP_013486.1 882067 R 4932 CDS NP_013487.1 6323415 851099 885288..888632 1 NC_001144.4 Smc6p; Protein involved in structural maintenance of chromosomes; essential subunit of Mms21-Smc5-Smc6 complex; required for growth, DNA repair, interchromosomal and sister chromatid recombination; homologous to S. pombe rad18 888632 SMC6 851099 SMC6 Saccharomyces cerevisiae Protein involved in structural maintenance of chromosomes; essential subunit of Mms21-Smc5-Smc6 complex; required for growth, DNA repair, interchromosomal and sister chromatid recombination; homologous to S. pombe rad18 NP_013487.1 885288 D 4932 CDS NP_013488.1 6323416 851100 complement(888851..892900) 1 NC_001144.4 Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD); Iki3p 892900 IKI3 851100 IKI3 Saccharomyces cerevisiae Iki3p NP_013488.1 888851 R 4932 CDS NP_013489.1 6323417 851101 complement(892992..893390) 1 NC_001144.4 Swc7p; Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin 893390 SWC7 851101 SWC7 Saccharomyces cerevisiae Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin NP_013489.1 892992 R 4932 CDS NP_013490.1 6323418 851102 893628..896270 1 NC_001144.4 Vac14p; Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p 896270 VAC14 851102 VAC14 Saccharomyces cerevisiae Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p NP_013490.1 893628 D 4932 CDS NP_013491.1 6323419 851103 complement(896374..897672) 1 NC_001144.4 Reh1p; Protein of unknown function, similar to Rei1p but not involved in bud growth; contains dispersed C2H2 zinc finger domains 897672 REH1 851103 REH1 Saccharomyces cerevisiae Protein of unknown function, similar to Rei1p but not involved in bud growth; contains dispersed C2H2 zinc finger domains NP_013491.1 896374 R 4932 CDS NP_013492.1 6323420 851104 898651..898821 1 NC_001144.4 Rps29ap; Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Bp and has similarity to rat S29 and E. coli S14 ribosomal proteins 898821 RPS29A 851104 RPS29A Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Bp and has similarity to rat S29 and E. coli S14 ribosomal proteins NP_013492.1 898651 D 4932 CDS NP_013493.2 42742289 851105 complement(899577..902660) 1 NC_001144.4 Ste23p; Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; member of the insulin-degrading enzyme family 902660 STE23 851105 STE23 Saccharomyces cerevisiae Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; member of the insulin-degrading enzyme family NP_013493.2 899577 R 4932 CDS NP_013494.1 6323422 851106 903066..903404 1 NC_001144.4 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Ecm19p 903404 ECM19 851106 ECM19 Saccharomyces cerevisiae Ecm19p NP_013494.1 903066 D 4932 CDS NP_013495.1 6323423 851107 903724..904440 1 NC_001144.4 Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall; Ccw14p 904440 CCW14 851107 CCW14 Saccharomyces cerevisiae Ccw14p NP_013495.1 903724 D 4932 CDS NP_013496.1 6323424 851108 complement(904749..906305) 1 NC_001144.4 Ylr392cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR392C is not an essential gene 906305 851108 YLR392C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR392C is not an essential gene NP_013496.1 904749 R 4932 CDS NP_013497.1 6323425 851109 907079..907918 1 NC_001144.4 Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6; Atp10p 907918 ATP10 851109 ATP10 Saccharomyces cerevisiae Atp10p NP_013497.1 907079 D 4932 CDS NP_013498.1 6323426 851110 907950..909398 1 NC_001144.4 SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; potential Cdc28p substrate; Cst9p 909398 CST9 851110 CST9 Saccharomyces cerevisiae Cst9p NP_013498.1 907950 D 4932 CDS NP_013499.1 6323427 851111 complement(909729..909965) 1 NC_001144.4 Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; Cox8p 909965 COX8 851111 COX8 Saccharomyces cerevisiae Cox8p NP_013499.1 909729 R 4932 CDS NP_013500.1 6323428 851112 complement(910235..912310) 1 NC_001144.4 Vps33p; ATP-binding protein that is a subunit of the HOPS complex and the CORVET tethering complex; essential for membrane docking and fusion at both the Golgi-to-endosome and endosome-to-vacuole stages of protein transport 912310 VPS33 851112 VPS33 Saccharomyces cerevisiae ATP-binding protein that is a subunit of the HOPS complex and the CORVET tethering complex; essential for membrane docking and fusion at both the Golgi-to-endosome and endosome-to-vacuole stages of protein transport NP_013500.1 910235 R 4932 CDS NP_013501.1 6323429 851113 complement(912550..914892) 1 NC_001144.4 Afg2p; ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; may be involved in degradation of aberrant mRNAs 914892 AFG2 851113 AFG2 Saccharomyces cerevisiae ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; may be involved in degradation of aberrant mRNAs NP_013501.1 912550 R 4932 CDS NP_013502.1 6323430 851114 complement(915156..919019) 1 NC_001144.4 Ski2p; Putative RNA helicase, involved in exosome mediated 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs; forms complex with Ski3p and Ski8p; required for repressing propagation of dsRNA viruses 919019 SKI2 851114 SKI2 Saccharomyces cerevisiae Putative RNA helicase, involved in exosome mediated 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs; forms complex with Ski3p and Ski8p; required for repressing propagation of dsRNA viruses NP_013502.1 915156 R 4932 CDS NP_013503.1 6323431 851115 complement(919536..921596) 1 NC_001144.4 Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p; Bdf1p 921596 BDF1 851115 BDF1 Saccharomyces cerevisiae Bdf1p NP_013503.1 919536 R 4932 CDS NP_013505.2 85666121 851117 complement(922442..924448) 1 NC_001144.4 Dus3p; Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region 924448 DUS3 851117 DUS3 Saccharomyces cerevisiae Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region NP_013505.2 922442 R 4932 CDS NP_013507.1 6323435 851119 925567..927618 1 NC_001144.4 Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation; Sfp1p 927618 SFP1 851119 SFP1 Saccharomyces cerevisiae Sfp1p NP_013507.1 925567 D 4932 CDS NP_013508.1 6323436 851120 928742..929599 1 NC_001144.4 Seipin protein involved in lipid droplet morphology; null mutants form lipid droplet clusters, especially in stationary phase, which appear to bud chaotically from the ER; corresponding gene in humans (BSCL2) causes lipodystrophy; Sei1p 929599 SEI1 851120 SEI1 Saccharomyces cerevisiae Sei1p NP_013508.1 928742 D 4932 CDS NP_013509.1 6323437 851121 929788..930891 1 NC_001144.4 Dus4p; Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p 930891 DUS4 851121 DUS4 Saccharomyces cerevisiae Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p NP_013509.1 929788 D 4932 CDS NP_013510.1 6323438 851122 complement(join(931064..931348,931698..931754)) 1 NC_001144.4 Rpl31bp; Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Ap and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p 931754 RPL31B 851122 RPL31B Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Ap and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p NP_013510.1 931064 R 4932 CDS NP_878135.1 33438847 1466423 complement(932205..932354) 1 NC_001144.4 Ylr406c-ap; Putative protein of unknown function 932354 1466423 YLR406C-A Saccharomyces cerevisiae Putative protein of unknown function NP_878135.1 932205 R 4932 CDS NP_013511.1 6323439 851123 932966..933655 1 NC_001144.4 Ylr407wp; Putative protein of unknown function; YLR407W is not an essential gene 933655 851123 YLR407W Saccharomyces cerevisiae Putative protein of unknown function; YLR407W is not an essential gene NP_013511.1 932966 D 4932 CDS NP_013512.1 6323440 851124 complement(933883..934251) 1 NC_001144.4 Ylr408cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene 934251 851124 YLR408C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene NP_013512.1 933883 R 4932 CDS NP_013513.1 6323441 851125 complement(934412..937231) 1 NC_001144.4 Utp21p; Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data 937231 UTP21 851125 UTP21 Saccharomyces cerevisiae Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data NP_013513.1 934412 R 4932 CDS NP_013514.1 6323442 851126 937539..940979 1 NC_001144.4 Vip1p; Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of IP7 by Vip1p is important for phosphate signaling; likely involved in cortical actin cytoskeleton function, by analogy with S. pombe ortholog asp1 940979 VIP1 851126 VIP1 Saccharomyces cerevisiae Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of IP7 by Vip1p is important for phosphate signaling; likely involved in cortical actin cytoskeleton function, by analogy with S. pombe ortholog asp1 NP_013514.1 937539 D 4932 CDS NP_058174.1 7839190 851128 join(941481..942773,942775..946794) 1 NC_001144.4 Ylr410w-bp; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 946794 851128 YLR410W-B Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_058174.1 941481 D 4932 CDS NP_058175.1 7839189 851127 941481..942797 1 NC_001144.4 Ylr410w-ap; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 942797 851127 YLR410W-A Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_058175.1 941481 D 4932 CDS NP_013515.1 6323443 851129 947251..947976 1 NC_001144.4 High-affinity copper transporter of the plasma membrane, acts as a trimer; gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae; Ctr3p 947976 CTR3 851129 CTR3 Saccharomyces cerevisiae Ctr3p NP_013515.1 947251 D 4932 CDS NP_013516.1 6323444 851130 948366..949190 1 NC_001144.4 Ylr412wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene 949190 851130 YLR412W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene NP_013516.1 948366 D 4932 CDS NP_878136.1 33438848 1466424 complement(950264..950470) 1 NC_001144.4 Ylr412c-ap; Putative protein of unknown function 950470 1466424 YLR412C-A Saccharomyces cerevisiae Putative protein of unknown function NP_878136.1 950264 R 4932 CDS NP_013517.1 6323445 851131 951153..953180 1 NC_001144.4 Ylr413wp; Putative protein of unknown function; YLR413W is not an essential gene 953180 851131 YLR413W Saccharomyces cerevisiae Putative protein of unknown function; YLR413W is not an essential gene NP_013517.1 951153 D 4932 CDS NP_013518.1 6323446 851132 complement(953350..954141) 1 NC_001144.4 Ylr414cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the bud and cytoplasm; Hog1p is required for transcriptional induction in response to cell wall damage; YLR414C is not an essential gene 954141 851132 YLR414C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the bud and cytoplasm; Hog1p is required for transcriptional induction in response to cell wall damage; YLR414C is not an essential gene NP_013518.1 953350 R 4932 CDS NP_013519.1 6323447 851133 complement(954256..954594) 1 NC_001144.4 Ylr415cp; Putative protein of unknown function; YLR415C is not an essential gene 954594 851133 YLR415C Saccharomyces cerevisiae Putative protein of unknown function; YLR415C is not an essential gene NP_013519.1 954256 R 4932 CDS NP_013521.1 6323449 851135 955007..956707 1 NC_001144.4 Vps36p; Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome 956707 VPS36 851135 VPS36 Saccharomyces cerevisiae Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome NP_013521.1 955007 D 4932 CDS NP_013522.1 6323450 851136 complement(956911..958092) 1 NC_001144.4 Constituent of Paf1 complex with RNA polymerase II, Paf1p, Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinct from Srb-containing Pol II complexes; required for expression of certain genes, modification of some histones, and telomere maintenance; Cdc73p 958092 CDC73 851136 CDC73 Saccharomyces cerevisiae Cdc73p NP_013522.1 956911 R 4932 CDS NP_013523.1 6323451 851137 958425..962732 1 NC_001144.4 Ylr419wp; Putative helicase with limited sequence similarity to human Rb protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR419W is not an essential gene 962732 851137 YLR419W Saccharomyces cerevisiae Putative helicase with limited sequence similarity to human Rb protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR419W is not an essential gene NP_013523.1 958425 D 4932 CDS NP_013524.1 6323452 851139 963782..964876 1 NC_001144.4 Ura4p; Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate 964876 URA4 851139 URA4 Saccharomyces cerevisiae Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate NP_013524.1 963782 D 4932 CDS NP_013525.1 6323453 851140 complement(965087..965557) 1 NC_001144.4 Subunit of the 19S regulatory particle of the 26S proteasome lid; Rpn13p 965557 RPN13 851140 RPN13 Saccharomyces cerevisiae Rpn13p NP_013525.1 965087 R 4932 CDS NP_013526.1 6323454 851141 965894..971692 1 NC_001144.4 Ylr422wp; Protein of unknown function with similarity to human DOCK proteins (guanine nucleotide exchange factors); interacts with Ino4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, YLR422W is not an essential protein 971692 851141 YLR422W Saccharomyces cerevisiae Protein of unknown function with similarity to human DOCK proteins (guanine nucleotide exchange factors); interacts with Ino4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, YLR422W is not an essential protein NP_013526.1 965894 D 4932 CDS NP_013527.1 6323455 851142 complement(971914..973167) 1 NC_001144.4 Scaffold potein responsible for pre-autophagosomal structure organization; interacts with and is required for activation of Apg1p protein kinase; involved in autophagy but not in the Cvt (cytoplasm to vacuole targeting) pathway; Atg17p 973167 ATG17 851142 ATG17 Saccharomyces cerevisiae Atg17p NP_013527.1 971914 R 4932 CDS NP_013528.1 6323456 851143 973392..975518 1 NC_001144.4 Spp382p; Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation 975518 SPP382 851143 SPP382 Saccharomyces cerevisiae Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation NP_013528.1 973392 D 4932 CDS NP_013529.1 6323457 851145 982891..986814 1 NC_001144.4 Tus1p; Guanine nucleotide exchange factor (GEF) that functions to modulate Rho1p activity as part of the cell integrity signaling pathway; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate 986814 TUS1 851145 TUS1 Saccharomyces cerevisiae Guanine nucleotide exchange factor (GEF) that functions to modulate Rho1p activity as part of the cell integrity signaling pathway; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate NP_013529.1 982891 D 4932 CDS NP_013530.1 6323458 851146 join(987059..987138,987210..988110) 1 NC_001144.4 Ylr426wp; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin 988110 851146 YLR426W Saccharomyces cerevisiae Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin NP_013530.1 987059 D 4932 CDS NP_013531.1 6323459 851147 988425..990437 1 NC_001144.4 Mag2p; Cytoplasmic protein of unknown function predicted to encode a DNA-3-methyladenine glycosidase II that catalyzes the hydrolysis of alkylated DNA 990437 MAG2 851147 MAG2 Saccharomyces cerevisiae Cytoplasmic protein of unknown function predicted to encode a DNA-3-methyladenine glycosidase II that catalyzes the hydrolysis of alkylated DNA NP_013531.1 988425 D 4932 CDS NP_013533.1 6323460 851148 990774..992729 1 NC_001144.4 Crn1p; Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity 992729 CRN1 851148 CRN1 Saccharomyces cerevisiae Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity NP_013533.1 990774 D 4932 CDS NP_013534.1 6323462 851150 993431..1000126 1 NC_001144.4 Sen1p; Presumed helicase required for RNA polymerase II transcription termination and processing of RNAs; homolog of Senataxin which causes Ataxia-Oculomotor Apraxia 2 and a dominant form of amyotrophic lateral sclerosis 1000126 SEN1 851150 SEN1 Saccharomyces cerevisiae Presumed helicase required for RNA polymerase II transcription termination and processing of RNAs; homolog of Senataxin which causes Ataxia-Oculomotor Apraxia 2 and a dominant form of amyotrophic lateral sclerosis NP_013534.1 993431 D 4932 CDS NP_013535.1 6323463 851151 complement(1000339..1001700) 1 NC_001144.4 Peripheral membrane protein, required for autophagy and for the cytoplasm-to-vacuole targeting (Cvt) pathway; Atg23p 1001700 ATG23 851151 ATG23 Saccharomyces cerevisiae Atg23p NP_013535.1 1000339 R 4932 CDS NP_013536.1 6323464 851152 1002554..1004125 1 NC_001144.4 Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed; Imd3p 1004125 IMD3 851152 IMD3 Saccharomyces cerevisiae Imd3p NP_013536.1 1002554 D 4932 CDS NP_013537.1 6323465 851153 complement(1004344..1006005) 1 NC_001144.4 Cna1p; Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1 1006005 CNA1 851153 CNA1 Saccharomyces cerevisiae Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1 NP_013537.1 1004344 R 4932 CDS NP_013539.2 37362680 851154 1006375..1006992 1 NC_001144.4 Tsr2p; Protein with a potential role in pre-rRNA processing 1006992 TSR2 851154 TSR2 Saccharomyces cerevisiae Protein with a potential role in pre-rRNA processing NP_013539.2 1006375 D 4932 CDS NP_013540.1 6323468 851156 complement(1007418..1011242) 1 NC_001144.4 Non-essential protein of unknown function; Ecm30p 1011242 ECM30 851156 ECM30 Saccharomyces cerevisiae Ecm30p NP_013540.1 1007418 R 4932 CDS NP_013541.1 6323469 851157 complement(1011619..1012020) 1 NC_001144.4 Ylr437cp; Putative protein of unknown function; epitope tagged protein localizes to the cytoplasm 1012020 851157 YLR437C Saccharomyces cerevisiae Putative protein of unknown function; epitope tagged protein localizes to the cytoplasm NP_013541.1 1011619 R 4932 CDS NP_013542.1 6323470 851158 1012498..1013772 1 NC_001144.4 L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; Car2p 1013772 CAR2 851158 CAR2 Saccharomyces cerevisiae Car2p NP_013542.1 1012498 D 4932 CDS NP_013543.1 6323471 851159 complement(1013906..1014175) 1 NC_001144.4 Lsm3p; Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA 1014175 LSM3 851159 LSM3 Saccharomyces cerevisiae Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA NP_013543.1 1013906 R 4932 CDS NP_013544.1 6323472 851160 1014488..1015447 1 NC_001144.4 Mrpl4p; Mitochondrial ribosomal protein of the large subunit 1015447 MRPL4 851160 MRPL4 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit NP_013544.1 1014488 D 4932 CDS NP_013545.1 6323473 851161 complement(1015565..1017694) 1 NC_001144.4 Sec39p; Protein of unknown function proposed to be involved in protein secretion; interacts with Dsl1p and localizes to the ER and nuclear envelope 1017694 SEC39 851161 SEC39 Saccharomyces cerevisiae Protein of unknown function proposed to be involved in protein secretion; interacts with Dsl1p and localizes to the ER and nuclear envelope NP_013545.1 1015565 R 4932 CDS NP_013546.1 6323474 851162 complement(1018138..1018905) 1 NC_001144.4 Rps1ap; Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Bp and has similarity to rat S3a ribosomal protein 1018905 RPS1A 851162 RPS1A Saccharomyces cerevisiae Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Bp and has similarity to rat S3a ribosomal protein NP_013546.1 1018138 R 4932 CDS NP_013547.1 6323475 851163 complement(1019312..1022248) 1 NC_001144.4 Sir3p; Silencing protein that interacts with Sir2p and Sir4p, and histone H3 and H4 tails, to establish a transcriptionally silent chromatin state; required for spreading of silenced chromatin; recruited to chromatin through interaction with Rap1p 1022248 SIR3 851163 SIR3 Saccharomyces cerevisiae Silencing protein that interacts with Sir2p and Sir4p, and histone H3 and H4 tails, to establish a transcriptionally silent chromatin state; required for spreading of silenced chromatin; recruited to chromatin through interaction with Rap1p NP_013547.1 1019312 R 4932 CDS NP_013548.1 6323476 851164 1022622..1023968 1 NC_001144.4 Non-essential protein of unknown function; Ecm7p 1023968 ECM7 851164 ECM7 Saccharomyces cerevisiae Ecm7p NP_013548.1 1022622 D 4932 CDS NP_013550.2 42742290 851166 join(1024186..1024569,1024652..1024834) 1 NC_001144.4 Ylr445wp; Putative protein of unknown function; transcription is regulated by Ume6p and induced in response to alpha factor 1024834 851166 YLR445W Saccharomyces cerevisiae Putative protein of unknown function; transcription is regulated by Ume6p and induced in response to alpha factor NP_013550.2 1024186 D 4932 CDS NP_013551.1 6323479 851167 1025211..1026512 1 NC_001144.4 Ylr446wp; Putative protein of unknown function with similarity to hexokinases; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene 1026512 851167 YLR446W Saccharomyces cerevisiae Putative protein of unknown function with similarity to hexokinases; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene NP_013551.1 1025211 D 4932 CDS NP_013552.1 6323480 851168 complement(1026853..1027890) 1 NC_001144.4 Vma6p; Subunit d of the five-subunit V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found in the endomembrane system; stabilizes VO subunits; required for V1 domain assembly on the vacuolar membrane 1027890 VMA6 851168 VMA6 Saccharomyces cerevisiae Subunit d of the five-subunit V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found in the endomembrane system; stabilizes VO subunits; required for V1 domain assembly on the vacuolar membrane NP_013552.1 1026853 R 4932 CDS NP_013553.1 6323481 851169 join(1028850..1028864,1029249..1029764) 1 NC_001144.4 Rpl6bp; Protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Ap and to rat L6 ribosomal protein; binds to 5.8S rRNA 1029764 RPL6B 851169 RPL6B Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Ap and to rat L6 ribosomal protein; binds to 5.8S rRNA NP_013553.1 1028850 D 4932 CDS NP_013554.1 6323482 851170 1030830..1032008 1 NC_001144.4 Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones; Fpr4p 1032008 FPR4 851170 FPR4 Saccharomyces cerevisiae Fpr4p NP_013554.1 1030830 D 4932 CDS NP_013555.1 6323483 851171 1032624..1035761 1 NC_001144.4 One of two isozymes of HMG-CoA reductase that convert HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks; Hmg2p 1035761 HMG2 851171 HMG2 Saccharomyces cerevisiae Hmg2p NP_013555.1 1032624 D 4932 CDS NP_013556.1 6323484 851172 1036090..1038750 1 NC_001144.4 Zinc-finger transcription factor that regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; positively regulated by alpha-isopropylmalate, an intermediate in leucine biosynthesis; Leu3p 1038750 LEU3 851172 LEU3 Saccharomyces cerevisiae Leu3p NP_013556.1 1036090 D 4932 CDS NP_013557.1 6323485 851173 complement(1039268..1041364) 1 NC_001144.4 Sst2p; GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family 1041364 SST2 851173 SST2 Saccharomyces cerevisiae GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family NP_013557.1 1039268 R 4932 CDS NP_013558.1 6323486 851174 complement(1041797..1042984) 1 NC_001144.4 Rif2p; Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation 1042984 RIF2 851174 RIF2 Saccharomyces cerevisiae Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation NP_013558.1 1041797 R 4932 CDS NP_013559.1 6323487 851175 1043996..1051882 1 NC_001144.4 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Fmp27p 1051882 FMP27 851175 FMP27 Saccharomyces cerevisiae Fmp27p NP_013559.1 1043996 D 4932 CDS NP_013560.1 6323488 851177 1053627..1054541 1 NC_001144.4 Ylr455wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) 1054541 851177 YLR455W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) NP_013560.1 1053627 D 4932 CDS NP_013561.1 6323489 851178 1055068..1055682 1 NC_001144.4 Ylr456wp; Putative protein of unknown function 1055682 851178 YLR456W Saccharomyces cerevisiae Putative protein of unknown function NP_013561.1 1055068 D 4932 CDS NP_013562.1 6323491 851180 complement(1055810..1056769) 1 NC_001144.4 Spindle pole body (SPB) component, required for the insertion of the duplication plaque into the nuclear membrane during SPB duplication; essential for bipolar spindle formation; component of the Mps2p-Bbp1p complex; Nbp1p 1056769 NBP1 851180 NBP1 Saccharomyces cerevisiae Nbp1p NP_013562.1 1055810 R 4932 CDS NP_013564.1 6323492 851181 1057332..1058516 1 NC_001144.4 Gab1p; GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI 1058516 GAB1 851181 GAB1 Saccharomyces cerevisiae GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI NP_013564.1 1057332 D 4932 CDS NP_013565.1 6323493 851182 complement(1059755..1060885) 1 NC_001144.4 Ylr460cp; Putative protein of unknown function, possibly up-regulated by iodine 1060885 851182 YLR460C Saccharomyces cerevisiae Putative protein of unknown function, possibly up-regulated by iodine NP_013565.1 1059755 R 4932 CDS NP_013566.1 6323494 851183 1062917..1063279 1 NC_001144.4 Pau4p; Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme 1063279 PAU4 851183 PAU4 Saccharomyces cerevisiae Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme NP_013566.1 1062917 D 4932 CDS NP_013567.1 6323495 851184 1065954..1066562 1 NC_001144.4 Ylr462wp; Putative protein of unknown function with similarity to helicases; YLR462W is within the telomere on the right arm of chromosome XII 1066562 851184 YLR462W Saccharomyces cerevisiae Putative protein of unknown function with similarity to helicases; YLR462W is within the telomere on the right arm of chromosome XII NP_013567.1 1065954 D 4932 CDS NP_013569.1 6323496 851185 join(1066570..1067082,1067362..1067499) 1 NC_001144.4 Ylr464wp; Putative protein of unknown function; intron is predicted but not detected experimentally; YLR464W overlaps the verified gene YRF1-4/YLR466W and two dubious ORFs YLR463C and YLR465C 1067499 851185 YLR464W Saccharomyces cerevisiae Putative protein of unknown function; intron is predicted but not detected experimentally; YLR464W overlaps the verified gene YRF1-4/YLR466W and two dubious ORFs YLR463C and YLR465C NP_013569.1 1066570 D 4932 CDS NP_013571.1 6323498 851187 1067085..1071233 1 NC_001144.4 Yrf1-4p; Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p 1071233 YRF1-4 851187 YRF1-4 Saccharomyces cerevisiae Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p NP_013571.1 1067085 D 4932 CDS NP_878137.1 33438849 1466425 complement(1071592..1071708) 1 NC_001144.4 Ylr466c-bp; Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data 1071708 1466425 YLR466C-B Saccharomyces cerevisiae Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data NP_878137.1 1071592 R 4932 CDS NP_013572.1 6323500 851189 1072506..1077896 1 NC_001144.4 Yrf1-5p; Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p 1077896 YRF1-5 851189 YRF1-5 Saccharomyces cerevisiae Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p NP_013572.1 1072506 D 4932 CDS NP_013573.1 6323502 854906 complement(join(461..3791,3891..4684)) 1 NC_001145.2 Yml133cp; Putative protein of unknown function with similarity to helicases; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YML133C contains an intron 4684 854906 YML133C Saccharomyces cerevisiae Putative protein of unknown function with similarity to helicases; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YML133C contains an intron NP_013573.1 461 R 4932 CDS NP_013574.1 6323503 854907 7244..8383 1 NC_001145.2 Protein involved in salt resistance; interacts with sodium:hydrogen antiporter Nha1p; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; Cos3p 8383 COS3 854907 COS3 Saccharomyces cerevisiae Cos3p NP_013574.1 7244 D 4932 CDS NP_013575.1 6323504 854908 10199..11296 1 NC_001145.2 Yml131wp; Putative protein of unknown function with similarity to oxidoreductases; HOG1 and SKO1-dependent mRNA expression is induced after osmotic shock; GFP-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS 11296 854908 YML131W Saccharomyces cerevisiae Putative protein of unknown function with similarity to oxidoreductases; HOG1 and SKO1-dependent mRNA expression is induced after osmotic shock; GFP-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS NP_013575.1 10199 D 4932 CDS NP_013576.1 6323505 854909 complement(11484..13175) 1 NC_001145.2 Thiol oxidase required for oxidative protein folding in the endoplasmic reticulum; Ero1p 13175 ERO1 854909 ERO1 Saccharomyces cerevisiae Ero1p NP_013576.1 11484 R 4932 CDS NP_013577.1 6323506 854910 complement(14542..14754) 1 NC_001145.2 Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; Cox14p 14754 COX14 854910 COX14 Saccharomyces cerevisiae Cox14p NP_013577.1 14542 R 4932 CDS NP_013578.1 6323507 854911 complement(15136..16677) 1 NC_001145.2 Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated; Msc1p 16677 MSC1 854911 MSC1 Saccharomyces cerevisiae Msc1p NP_013578.1 15136 R 4932 CDS NP_013579.1 6323508 854912 17065..18810 1 NC_001145.2 Rsc9p; Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway 18810 RSC9 854912 RSC9 Saccharomyces cerevisiae Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway NP_013579.1 17065 D 4932 CDS NP_013580.1 6323509 854913 complement(19061..20536) 1 NC_001145.2 Erg13p; 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis 20536 ERG13 854913 ERG13 Saccharomyces cerevisiae 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis NP_013580.1 19061 R 4932 CDS NP_013581.1 6323510 854914 complement(20762..21700) 1 NC_001145.2 Pga3p; Essential protein required for maturation of Gas1p and Pho8p, protein trafficking; GFP-fusion protein localizes to the endoplasmic reticulum; null mutants have a cell separation defect 21700 PGA3 854914 PGA3 Saccharomyces cerevisiae Essential protein required for maturation of Gas1p and Pho8p, protein trafficking; GFP-fusion protein localizes to the endoplasmic reticulum; null mutants have a cell separation defect NP_013581.1 20762 R 4932 CDS NP_013582.1 6323511 854915 complement(join(22049..23361,23660..23684)) 1 NC_001145.2 Tub3p; Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p 23684 TUB3 854915 TUB3 Saccharomyces cerevisiae Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p NP_013582.1 22049 R 4932 CDS NP_013583.1 6323512 854916 complement(24038..25801) 1 NC_001145.2 Pho84p; High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p 25801 PHO84 854916 PHO84 Saccharomyces cerevisiae High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p NP_013583.1 24038 R 4932 CDS NP_013585.1 6323514 854918 26930..27862 1 NC_001145.2 Gtr1p; Cytoplasmic GTP binding protein and negative regulator, with homolog Gtr2p, of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport; has homology to human RagA and RagB 27862 GTR1 854918 GTR1 Saccharomyces cerevisiae Cytoplasmic GTP binding protein and negative regulator, with homolog Gtr2p, of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport; has homology to human RagA and RagB NP_013585.1 26930 D 4932 CDS NP_013586.1 6323515 854919 complement(28266..29807) 1 NC_001145.2 Ndi1p; NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; homolog of human AMID 29807 NDI1 854919 NDI1 Saccharomyces cerevisiae NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; homolog of human AMID NP_013586.1 28266 R 4932 CDS NP_013587.1 6323516 854920 30611..31684 1 NC_001145.2 Yml119wp; Putative protein of unknown funtion; YML119W is not an essential gene; potential Cdc28p substrate 31684 854920 YML119W Saccharomyces cerevisiae Putative protein of unknown funtion; YML119W is not an essential gene; potential Cdc28p substrate NP_013587.1 30611 D 4932 CDS NP_013588.1 6323517 854921 32334..33851 1 NC_001145.2 Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p and Ngl2p; Ngl3p 33851 NGL3 854921 NGL3 Saccharomyces cerevisiae Ngl3p NP_013588.1 32334 D 4932 CDS NP_013589.1 6323518 854922 34243..37647 1 NC_001145.2 Putative RNA-binding protein, based on computational analysis of large-scale protein-protein interaction data; Nab6p 37647 NAB6 854922 NAB6 Saccharomyces cerevisiae Nab6p NP_013589.1 34243 D 4932 CDS NP_013591.1 6323520 854924 38196..39824 1 NC_001145.2 Multidrug efflux pump of the major facilitator superfamily, required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; Atr1p 39824 ATR1 854924 ATR1 Saccharomyces cerevisiae Atr1p NP_013591.1 38196 D 4932 CDS NP_013592.1 6323521 854925 complement(40187..41794) 1 NC_001145.2 Van1p; Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant 41794 VAN1 854925 VAN1 Saccharomyces cerevisiae Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant NP_013592.1 40187 R 4932 CDS NP_013593.1 6323522 854926 complement(42043..43575) 1 NC_001145.2 Taf8p; TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation 43575 TAF8 854926 TAF8 Saccharomyces cerevisiae TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation NP_013593.1 42043 R 4932 CDS NP_013594.1 6323523 854927 44045..44791 1 NC_001145.2 Dat1p; DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability 44791 DAT1 854927 DAT1 Saccharomyces cerevisiae DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability NP_013594.1 44045 D 4932 CDS NP_013595.1 6323524 854928 45063..45953 1 NC_001145.2 Gamma subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing; Ctk3p 45953 CTK3 854928 CTK3 Saccharomyces cerevisiae Ctk3p NP_013595.1 45063 D 4932 CDS NP_013596.1 6323525 854929 46942..49704 1 NC_001145.2 Component of the Rsp5p E3-ubiquitin ligase complex, involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions, functional homolog of BUL1; Bul2p 49704 BUL2 854929 BUL2 Saccharomyces cerevisiae Bul2p NP_013596.1 46942 D 4932 CDS NP_013597.1 6323526 854930 complement(50031..50954) 1 NC_001145.2 Coq5p; 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes 50954 COQ5 854930 COQ5 Saccharomyces cerevisiae 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes NP_013597.1 50031 R 4932 CDS NP_013598.1 6323527 854931 51640..54468 1 NC_001145.2 Zds2p; Protein that interacts with silencing proteins at the telomere, involved in transcriptional silencing; paralog of Zds1p 54468 ZDS2 854931 ZDS2 Saccharomyces cerevisiae Protein that interacts with silencing proteins at the telomere, involved in transcriptional silencing; paralog of Zds1p NP_013598.1 51640 D 4932 CDS NP_013599.1 6323528 854863 54793..55110 1 NC_001145.2 Yml108wp; Putative protein of unknown function whose structure defines a new subfamily of the split beta-alpha-beta sandwiches; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YML108W is not an essential gene 55110 854863 YML108W Saccharomyces cerevisiae Putative protein of unknown function whose structure defines a new subfamily of the split beta-alpha-beta sandwiches; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YML108W is not an essential gene NP_013599.1 54793 D 4932 CDS NP_013600.2 37362681 854864 complement(55265..56269) 1 NC_001145.2 Protein required for nuclear retention of unspliced pre-mRNAs along with Mlp1p and Pml1p; anchored to nuclear pore complex via Mlp1p and Mlp2p; found with the subset of nuclear pores farthest from the nucleolus; may interact with ribosomes; Pml39p 56269 PML39 854864 PML39 Saccharomyces cerevisiae Pml39p NP_013600.2 55265 R 4932 CDS NP_013601.1 6323530 854865 56773..57453 1 NC_001145.2 Ura5p; One of two orotate phosphoribosyltransferase isozymes (see also URA10) that catalyze the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate 57453 URA5 854865 URA5 Saccharomyces cerevisiae One of two orotate phosphoribosyltransferase isozymes (see also URA10) that catalyze the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate NP_013601.1 56773 D 4932 CDS NP_013602.1 6323531 854866 complement(57866..58687) 1 NC_001145.2 Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19; Sec65p 58687 SEC65 854866 SEC65 Saccharomyces cerevisiae Sec65p NP_013602.1 57866 R 4932 CDS NP_013603.1 6323532 854867 complement(58939..62322) 1 NC_001145.2 Mdm1p; Intermediate filament protein, required for nuclear and mitochondrial transmission to daughter buds; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P) 62322 MDM1 854867 MDM1 Saccharomyces cerevisiae Intermediate filament protein, required for nuclear and mitochondrial transmission to daughter buds; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P) NP_013603.1 58939 R 4932 CDS NP_013604.1 6323533 854868 complement(62582..67549) 1 NC_001145.2 Subunit of the nuclear pore complex (NPC), involved in the structural organization of the complex and of the nuclear envelope, also involved in nuclear envelope permeability, interacts with Pom152p and Nic96p; Nup188p 67549 NUP188 854868 NUP188 Saccharomyces cerevisiae Nup188p NP_013604.1 62582 R 4932 CDS NP_013605.1 6323534 854869 68294..69700 1 NC_001145.2 Component of the chromatin assembly complex (with Rlf2p and Msi1p) that assembles newly synthesized histones onto recently replicated DNA, required for building functional kinetochores, conserved from yeast to humans; Cac2p 69700 CAC2 854869 CAC2 Saccharomyces cerevisiae Cac2p NP_013605.1 68294 D 4932 CDS NP_013607.1 6323536 854871 complement(69735..70088) 1 NC_001145.2 Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; Cue4p 70088 CUE4 854871 CUE4 Saccharomyces cerevisiae Cue4p NP_013607.1 69735 R 4932 CDS NP_878138.1 33438850 1466496 70138..70311 1 NC_001145.2 Yml100w-ap; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 70311 1466496 YML100W-A Saccharomyces cerevisiae Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching NP_878138.1 70138 D 4932 CDS NP_013608.1 6323537 854872 70624..73920 1 NC_001145.2 Tsl1p; Large subunit of trehalose 6-phosphate synthase (Tps1p)/phosphatase (Tps2p) complex, which converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose, homologous to Tps3p and may share function 73920 TSL1 854872 TSL1 Saccharomyces cerevisiae Large subunit of trehalose 6-phosphate synthase (Tps1p)/phosphatase (Tps2p) complex, which converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose, homologous to Tps3p and may share function NP_013608.1 70624 D 4932 CDS NP_013610.1 6323539 854874 complement(74398..77040) 1 NC_001145.2 Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p; Arg81p 77040 ARG81 854874 ARG81 Saccharomyces cerevisiae Arg81p NP_013610.1 74398 R 4932 CDS NP_013611.1 6323540 854875 77267..77770 1 NC_001145.2 Taf13p; TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors 77770 TAF13 854875 TAF13 Saccharomyces cerevisiae TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors NP_013611.1 77267 D 4932 CDS NP_013612.1 6323541 854876 complement(78335..79690) 1 NC_001145.2 Vps9p; A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin 79690 VPS9 854876 VPS9 Saccharomyces cerevisiae A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin NP_013612.1 78335 R 4932 CDS NP_013613.1 6323542 854877 79909..81486 1 NC_001145.2 Yml096wp; Putative protein of unknown function with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10 81486 854877 YML096W Saccharomyces cerevisiae Putative protein of unknown function with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10 NP_013613.1 79909 D 4932 CDS NP_013614.1 6323543 854878 complement(81481..82113) 1 NC_001145.2 Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein; Rad10p 82113 RAD10 854878 RAD10 Saccharomyces cerevisiae Rad10p NP_013614.1 81481 R 4932 CDS NP_013616.1 6323544 854879 join(82275..82290,82374..82849) 1 NC_001145.2 Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it; Gim5p 82849 GIM5 854879 GIM5 Saccharomyces cerevisiae Gim5p NP_013616.1 82275 D 4932 CDS NP_013617.1 6323546 854881 83090..85789 1 NC_001145.2 Utp14p; Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA 85789 UTP14 854881 UTP14 Saccharomyces cerevisiae Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA NP_013617.1 83090 D 4932 CDS NP_013618.1 6323547 854882 complement(85987..86739) 1 NC_001145.2 Pre8p; 20S proteasome beta-type subunit 86739 PRE8 854882 PRE8 Saccharomyces cerevisiae 20S proteasome beta-type subunit NP_013618.1 85987 R 4932 CDS NP_013619.1 6323548 854883 complement(87123..90731) 1 NC_001145.2 Rpm2p; Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus 90731 RPM2 854883 RPM2 Saccharomyces cerevisiae Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus NP_013619.1 87123 R 4932 CDS NP_013622.1 6323551 854886 92235..94241 1 NC_001145.2 Ufo1p; F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation 94241 UFO1 854886 UFO1 Saccharomyces cerevisiae F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation NP_013622.1 92235 D 4932 CDS NP_013623.1 6323552 854887 complement(94431..95369) 1 NC_001145.2 Putative protein of unknown function; null mutant displays increased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media; Aim33p 95369 AIM33 854887 AIM33 Saccharomyces cerevisiae Aim33p NP_013623.1 94431 R 4932 CDS NP_013624.1 6323553 854888 complement(95791..97371) 1 NC_001145.2 D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of D-erythroascorbic acid, which is protective against oxidative stress; Alo1p 97371 ALO1 854888 ALO1 Saccharomyces cerevisiae Alo1p NP_013624.1 95791 R 4932 CDS NP_013625.1 6323554 854889 complement(join(97941..99259,99376..99400)) 1 NC_001145.2 Tub1p; Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules 99400 TUB1 854889 TUB1 Saccharomyces cerevisiae Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules NP_013625.1 97941 R 4932 CDS NP_013627.1 6323556 854891 complement(99794..101050) 1 NC_001145.2 Yml083cp; Putative protein of unknown function; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions 101050 854891 YML083C Saccharomyces cerevisiae Putative protein of unknown function; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions NP_013627.1 99794 R 4932 CDS NP_013628.1 6323557 854892 101862..103811 1 NC_001145.2 Yml082wp; Putative protein predicted to have carbon-sulfur lyase activity; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YNML082W is not an essential gene 103811 854892 YML082W Saccharomyces cerevisiae Putative protein predicted to have carbon-sulfur lyase activity; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YNML082W is not an essential gene NP_013628.1 101862 D 4932 CDS NP_013629.1 6323558 854893 complement(103983..104162) 1 NC_001145.2 Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms; Atp18p 104162 ATP18 854893 ATP18 Saccharomyces cerevisiae Atp18p NP_013629.1 103983 R 4932 CDS NP_013630.1 6323559 854894 104777..108532 1 NC_001145.2 Yml081wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YML081w is not an essential gene 108532 854894 YML081W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YML081w is not an essential gene NP_013630.1 104777 D 4932 CDS NP_013631.1 6323560 854895 108806..110077 1 NC_001145.2 Dus1p; Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17 110077 DUS1 854895 DUS1 Saccharomyces cerevisiae Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17 NP_013631.1 108806 D 4932 CDS NP_013632.1 6323561 854896 110247..110852 1 NC_001145.2 Yml079wp; Non-essential protein of unknown function with structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to the nucleus and cytoplasm 110852 854896 YML079W Saccharomyces cerevisiae Non-essential protein of unknown function with structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to the nucleus and cytoplasm NP_013632.1 110247 D 4932 CDS NP_013633.1 6323562 854897 111002..111550 1 NC_001145.2 Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria; Cpr3p 111550 CPR3 854897 CPR3 Saccharomyces cerevisiae Cpr3p NP_013633.1 111002 D 4932 CDS NP_013634.1 6323563 854898 111865..112344 1 NC_001145.2 Component of the TRAPP (transport protein particle) complex, which plays an essential role in the vesicular transport from endoplasmic reticulum to Golgi; Bet5p 112344 BET5 854898 BET5 Saccharomyces cerevisiae Bet5p NP_013634.1 111865 D 4932 CDS NP_013635.1 6323564 854899 complement(112513..115347) 1 NC_001145.2 War1p; Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively 115347 WAR1 854899 WAR1 Saccharomyces cerevisiae Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively NP_013635.1 112513 R 4932 CDS NP_013636.1 6323565 854900 complement(115734..118898) 1 NC_001145.2 One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae; Hmg1p 118898 HMG1 854900 HMG1 Saccharomyces cerevisiae Hmg1p NP_013636.1 115734 R 4932 CDS NP_013637.1 6323566 854901 complement(120089..121324) 1 NC_001145.2 Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p; Fpr3p 121324 FPR3 854901 FPR3 Saccharomyces cerevisiae Fpr3p NP_013637.1 120089 R 4932 CDS NP_013638.1 6323567 854902 complement(join(123227..123742,124158..124172)) 1 NC_001145.2 Rpl6ap; N-terminally acetylated protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Bp and to rat L6 ribosomal protein; binds to 5.8S rRNA 124172 RPL6A 854902 RPL6A Saccharomyces cerevisiae N-terminally acetylated protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Bp and to rat L6 ribosomal protein; binds to 5.8S rRNA NP_013638.1 123227 R 4932 CDS NP_013639.1 6323568 854903 complement(124730..129367) 1 NC_001145.2 Tcb3p; Lipid-binding protein, localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; GFP-fusion protein localizes to the cell periphery; C-termini of Tcb1p, Tcb2p and Tcb3p interact 129367 TCB3 854903 TCB3 Saccharomyces cerevisiae Lipid-binding protein, localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; GFP-fusion protein localizes to the cell periphery; C-termini of Tcb1p, Tcb2p and Tcb3p interact NP_013639.1 124730 R 4932 CDS NP_013640.1 6323569 854904 complement(129749..131572) 1 NC_001145.2 Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; Cog8p 131572 COG8 854904 COG8 Saccharomyces cerevisiae Cog8p NP_013640.1 129749 R 4932 CDS NP_013641.1 6323570 854932 133475..135229 1 NC_001145.2 Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation; Dak1p 135229 DAK1 854932 DAK1 Saccharomyces cerevisiae Dak1p NP_013641.1 133475 D 4932 CDS NP_013642.1 6323571 854933 135500..137158 1 NC_001145.2 Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which facilitates RNA Pol II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structure; interacts with DNA polymerase alpha (Pol1p); Pob3p 137158 POB3 854933 POB3 Saccharomyces cerevisiae Pob3p NP_013642.1 135500 D 4932 CDS NP_013643.1 6323572 854934 137550..138944 1 NC_001145.2 Protein that modulates the efficiency of translation termination, interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins; Itt1p 138944 ITT1 854934 ITT1 Saccharomyces cerevisiae Itt1p NP_013643.1 137550 D 4932 CDS NP_013644.1 6323573 854935 complement(join(139063..140090,140184..140214)) 1 NC_001145.2 Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein; Erv41p 140214 ERV41 854935 ERV41 Saccharomyces cerevisiae Erv41p NP_013644.1 139063 R 4932 CDS NP_013645.1 6323574 854936 complement(140424..141533) 1 NC_001145.2 Sma2p; Protein of unknown function involved in the assembly of the prospore membrane during sporulation 141533 SMA2 854936 SMA2 Saccharomyces cerevisiae Protein of unknown function involved in the assembly of the prospore membrane during sporulation NP_013645.1 140424 R 4932 CDS NP_013646.1 6323575 854937 142210..144954 1 NC_001145.2 Orc1p; Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; exhibits ATPase activity 144954 ORC1 854937 ORC1 Saccharomyces cerevisiae Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; exhibits ATPase activity NP_013646.1 142210 D 4932 CDS NP_013647.1 6323576 854938 complement(145139..145876) 1 NC_001145.2 Tem1p; GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis 145876 TEM1 854938 TEM1 Saccharomyces cerevisiae GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis NP_013647.1 145139 R 4932 CDS NP_013648.1 6323577 854939 146482..147249 1 NC_001145.2 Rps1bp; Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Ap and has similarity to rat S3a ribosomal protein 147249 RPS1B 854939 RPS1B Saccharomyces cerevisiae Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Ap and has similarity to rat S3a ribosomal protein NP_013648.1 146482 D 4932 CDS NP_013649.1 6323578 854940 complement(147505..148683) 1 NC_001145.2 Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance; Mft1p 148683 MFT1 854940 MFT1 Saccharomyces cerevisiae Mft1p NP_013649.1 147505 R 4932 CDS NP_013650.1 6323579 854941 complement(148953..151532) 1 NC_001145.2 Pif1p; DNA helicase involved in telomere formation and elongation; acts as a catalytic inhibitor of telomerase; also plays a role in repair and recombination of mitochondrial DNA 151532 PIF1 854941 PIF1 Saccharomyces cerevisiae DNA helicase involved in telomere formation and elongation; acts as a catalytic inhibitor of telomerase; also plays a role in repair and recombination of mitochondrial DNA NP_013650.1 148953 R 4932 CDS NP_013651.1 6323580 854942 151871..153001 1 NC_001145.2 Ogg1p; Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA 153001 OGG1 854942 OGG1 Saccharomyces cerevisiae Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA NP_013651.1 151871 D 4932 CDS NP_013652.1 6323581 854943 complement(153219..158258) 1 NC_001145.2 Serine esterase that deacylates exogenous lysophospholipids, homolog of human neuropathy target esterase (NTE); mammalian NTE1 deacylates phosphatidylcholine to glycerophosphocholine; Nte1p 158258 NTE1 854943 NTE1 Saccharomyces cerevisiae Nte1p NP_013652.1 153219 R 4932 CDS NP_219498.1 15530185 854944 158760..158966 1 NC_001145.2 Protein involved in the Mec1p-mediated checkpoint pathway that responds to DNA damage or replication arrest, transcription is induced by DNA damage; Hug1p 158966 HUG1 854944 HUG1 Saccharomyces cerevisiae Hug1p NP_219498.1 158760 D 4932 CDS NP_013653.1 6323582 854945 159383..159697 1 NC_001145.2 Sml1p; Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase 159697 SML1 854945 SML1 Saccharomyces cerevisiae Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase NP_013653.1 159383 D 4932 CDS NP_013655.1 6323583 854946 160180..161994 1 NC_001145.2 Cmp2p; Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1 161994 CMP2 854946 CMP2 Saccharomyces cerevisiae Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1 NP_013655.1 160180 D 4932 CDS NP_013656.1 6323585 854948 complement(join(162194..163308,163717..164176)) 1 NC_001145.2 Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed; Imd4p 164176 IMD4 854948 IMD4 Saccharomyces cerevisiae Imd4p NP_013656.1 162194 R 4932 CDS NP_013657.1 6323586 854949 164790..165326 1 NC_001145.2 Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25; Spc2p 165326 SPC2 854949 SPC2 Saccharomyces cerevisiae Spc2p NP_013657.1 164790 D 4932 CDS NP_013658.1 6323587 854950 complement(165533..167308) 1 NC_001145.2 Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions; Cyb2p 167308 CYB2 854950 CYB2 Saccharomyces cerevisiae Cyb2p NP_013658.1 165533 R 4932 CDS NP_878139.1 33438851 1466497 complement(167623..167781) 1 NC_001145.2 Yml054c-ap; Putative protein of unknown function 167781 1466497 YML054C-A Saccharomyces cerevisiae Putative protein of unknown function NP_878139.1 167623 R 4932 CDS NP_013659.1 6323588 854952 complement(169116..169754) 1 NC_001145.2 Yml053cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YML053C is not an essential gene 169754 854952 YML053C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YML053C is not an essential gene NP_013659.1 169116 R 4932 CDS NP_013660.1 6323589 854953 170402..171310 1 NC_001145.2 Sur7p; Putative integral membrane protein; component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants 171310 SUR7 854953 SUR7 Saccharomyces cerevisiae Putative integral membrane protein; component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants NP_013660.1 170402 D 4932 CDS NP_013661.1 6323590 854954 171594..172901 1 NC_001145.2 Transcriptional regulator involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding; Gal80p 172901 GAL80 854954 GAL80 Saccharomyces cerevisiae Gal80p NP_013661.1 171594 D 4932 CDS NP_013662.1 6323591 854955 173139..174074 1 NC_001145.2 Putative protein of unknown function; non-essential gene; null mutant displays increased frequency of mitochondrial genome loss (petite formation); Aim32p 174074 AIM32 854955 AIM32 Saccharomyces cerevisiae Aim32p NP_013662.1 173139 D 4932 CDS NP_013663.1 6323592 854956 complement(174220..178305) 1 NC_001145.2 Rse1p; Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport 178305 RSE1 854956 RSE1 Saccharomyces cerevisiae Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport NP_013663.1 174220 R 4932 CDS NP_013664.1 6323593 854957 178426..179637 1 NC_001145.2 Gsf2p; ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression 179637 GSF2 854957 GSF2 Saccharomyces cerevisiae ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression NP_013664.1 178426 D 4932 CDS NP_013666.1 6323595 854959 complement(180017..181075) 1 NC_001145.2 Prm6p; Pheromone-regulated protein, predicted to have 2 transmembrane segments; regulated by Ste12p during mating 181075 PRM6 854959 PRM6 Saccharomyces cerevisiae Pheromone-regulated protein, predicted to have 2 transmembrane segments; regulated by Ste12p during mating NP_013666.1 180017 R 4932 CDS NP_013667.1 6323596 854960 181474..183363 1 NC_001145.2 U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats; Prp39p 183363 PRP39 854960 PRP39 Saccharomyces cerevisiae Prp39p NP_013667.1 181474 D 4932 CDS NP_013668.1 6323597 854963 join(184461..185765,185767..189729) 1 NC_001145.2 Yml045wp; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 189729 854963 YML045W Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_013668.1 184461 D 4932 CDS NP_058176.1 7839191 854962 184461..185783 1 NC_001145.2 Yml045w-ap; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 185783 854962 YML045W-A Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_058176.1 184461 D 4932 CDS NP_013669.1 6323598 854964 complement(190244..191767) 1 NC_001145.2 Rrn11p; Protein required for rDNA transcription by RNA polymerase I, component of the core factor (CF) of rDNA transcription factor, which also contains Rrn6p and Rrn7p 191767 RRN11 854964 RRN11 Saccharomyces cerevisiae Protein required for rDNA transcription by RNA polymerase I, component of the core factor (CF) of rDNA transcription factor, which also contains Rrn6p and Rrn7p NP_013669.1 190244 R 4932 CDS NP_013670.1 6323599 854965 192788..194800 1 NC_001145.2 Cat2p; Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes 194800 CAT2 854965 CAT2 Saccharomyces cerevisiae Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes NP_013670.1 192788 D 4932 CDS NP_013671.1 6323600 854966 complement(194913..195755) 1 NC_001145.2 Vps71p; Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting 195755 VPS71 854966 VPS71 Saccharomyces cerevisiae Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting NP_013671.1 194913 R 4932 CDS NP_013672.1 6323601 854969 join(196628..197932,197934..201896) 1 NC_001145.2 Yml039wp; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 201896 854969 YML039W Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_013672.1 196628 D 4932 CDS NP_013673.1 6323602 854968 196628..197950 1 NC_001145.2 Yml040wp; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 197950 854968 YML040W Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_013673.1 196628 D 4932 CDS NP_013674.1 6323603 854970 complement(202775..204103) 1 NC_001145.2 Ymd8p; Putative nucleotide sugar transporter, has similarity to Vrg4p 204103 YMD8 854970 YMD8 Saccharomyces cerevisiae Putative nucleotide sugar transporter, has similarity to Vrg4p NP_013674.1 202775 R 4932 CDS NP_013675.1 6323604 854971 complement(204386..205408) 1 NC_001145.2 Yml037cp; Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene 205408 854971 YML037C Saccharomyces cerevisiae Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene NP_013675.1 204386 R 4932 CDS NP_013676.2 154199620 854972 join(205642..206097,206204..206293) 1 NC_001145.2 Protein involved in telomere uncapping and elongation as component of the KEOPS protein complex with Bud32p, Kae1p, Pcc1p, and Gon7p; also shown to be a component of the EKC protein complex; homolog of human CGI-121; Cgi121p 206293 CGI121 854972 CGI121 Saccharomyces cerevisiae Cgi121p NP_013676.2 205642 D 4932 CDS NP_013677.1 6323606 854973 complement(206428..208860) 1 NC_001145.2 Amd1p; AMP deaminase, tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; may be involved in regulation of intracellular adenine nucleotide pools 208860 AMD1 854973 AMD1 Saccharomyces cerevisiae AMP deaminase, tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; may be involved in regulation of intracellular adenine nucleotide pools NP_013677.1 206428 R 4932 CDS NP_013679.1 6323607 854974 join(209525..211444,211571..212155) 1 NC_001145.2 Src1p; Inner nuclear membrane (INM) protein with a putative role in sister chromatid segregation, potentially phosphorylated by Cdc28p; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence 212155 SRC1 854974 SRC1 Saccharomyces cerevisiae Inner nuclear membrane (INM) protein with a putative role in sister chromatid segregation, potentially phosphorylated by Cdc28p; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence NP_013679.1 209525 D 4932 CDS NP_013680.2 27808713 854976 complement(212515..213930) 1 NC_001145.2 Rad52p; Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis 213930 RAD52 854976 RAD52 Saccharomyces cerevisiae Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis NP_013680.2 212515 R 4932 CDS NP_013681.1 6323610 854977 214189..216156 1 NC_001145.2 Nuclear envelope protein with multiple putative transmembrane domains, required for nuclear pore complex assembly and spindle pole body duplication; required for meiosis II; Ndc1p 216156 NDC1 854977 NDC1 Saccharomyces cerevisiae Ndc1p NP_013681.1 214189 D 4932 CDS NP_013682.1 6323611 854978 216435..216914 1 NC_001145.2 Putative protein of unknown function; GFP-fusion protein localizes to mitochondria; null mutant is viable and displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth rate in minimal glycerol media; Aim31p 216914 AIM31 854978 AIM31 Saccharomyces cerevisiae Aim31p NP_013682.1 216435 D 4932 CDS NP_013683.1 6323612 854979 217362..219878 1 NC_001145.2 Usa1p; Protein involved in ER-associated protein degradation (ERAD); component of the Hrd1p complex; interacts with the U1 snRNP-specific protein, Snp1p 219878 USA1 854979 USA1 Saccharomyces cerevisiae Protein involved in ER-associated protein degradation (ERAD); component of the Hrd1p complex; interacts with the U1 snRNP-specific protein, Snp1p NP_013683.1 217362 D 4932 CDS NP_013684.1 6323613 854980 220138..220728 1 NC_001145.2 Ubiquitous housekeeping thioredoxin peroxidase, reduces reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; mediates redox regulation of the nuclear localization of Yap1p; deletion results in mutator phenotype; Tsa1p 220728 TSA1 854980 TSA1 Saccharomyces cerevisiae Tsa1p NP_013684.1 220138 D 4932 CDS NP_013685.1 6323614 854981 221406..222563 1 NC_001145.2 Yox1p; Homeodomain-containing transcriptional repressor, binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate 222563 YOX1 854981 YOX1 Saccharomyces cerevisiae Homeodomain-containing transcriptional repressor, binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate NP_013685.1 221406 D 4932 CDS NP_013686.1 6323615 854982 complement(join(222987..223380,223782..223828)) 1 NC_001145.2 Rps18bp; Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Ap and has similarity to E. coli S13 and rat S18 ribosomal proteins 223828 RPS18B 854982 RPS18B Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Ap and has similarity to E. coli S13 and rat S18 ribosomal proteins NP_013686.1 222987 R 4932 CDS NP_013687.1 6323616 854983 complement(join(224406..225239,225339..225365)) 1 NC_001145.2 Yml6p; Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins 225365 YML6 854983 YML6 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins NP_013687.1 224406 R 4932 CDS NP_013688.1 6323617 854984 join(225889..225891,226290..226697) 1 NC_001145.2 Rps17ap; Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Bp and has similarity to rat S17 ribosomal protein 226697 RPS17A 854984 RPS17A Saccharomyces cerevisiae Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Bp and has similarity to rat S17 ribosomal protein NP_013688.1 225889 D 4932 CDS NP_013689.1 6323618 854985 complement(226994..228664) 1 NC_001145.2 Nse5p; Essential subunit of the Mms21-Smc5-Smc6 complex; required for cell viability and DNA repair 228664 NSE5 854985 NSE5 Saccharomyces cerevisiae Essential subunit of the Mms21-Smc5-Smc6 complex; required for cell viability and DNA repair NP_013689.1 226994 R 4932 CDS NP_013690.1 6323619 854986 228937..229500 1 NC_001145.2 Apt1p; Adenine phosphoribosyltransferase, catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis 229500 APT1 854986 APT1 Saccharomyces cerevisiae Adenine phosphoribosyltransferase, catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis NP_013690.1 228937 D 4932 CDS NP_013691.1 6323620 854987 complement(229734..230813) 1 NC_001145.2 Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus; Ung1p 230813 UNG1 854987 UNG1 Saccharomyces cerevisiae Ung1p NP_013691.1 229734 R 4932 CDS NP_013692.1 6323621 854988 231149..233143 1 NC_001145.2 Yml020wp; Putative protein of unknown function 233143 854988 YML020W Saccharomyces cerevisiae Putative protein of unknown function NP_013692.1 231149 D 4932 CDS NP_013693.1 6323622 854989 233457..234455 1 NC_001145.2 Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p; Ost6p 234455 OST6 854989 OST6 Saccharomyces cerevisiae Ost6p NP_013693.1 233457 D 4932 CDS NP_013694.1 6323623 854990 complement(234771..235952) 1 NC_001145.2 Yml018cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; YML018C is not an essential gene 235952 854990 YML018C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; YML018C is not an essential gene NP_013694.1 234771 R 4932 CDS NP_013695.2 41629688 854991 join(236588..236591,236954..238731) 1 NC_001145.2 Psp2p; Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing 238731 PSP2 854991 PSP2 Saccharomyces cerevisiae Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing NP_013695.2 236588 D 4932 CDS NP_013696.1 6323625 854992 complement(239458..241536) 1 NC_001145.2 Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance; Ppz1p 241536 PPZ1 854992 PPZ1 Saccharomyces cerevisiae Ppz1p NP_013696.1 239458 R 4932 CDS NP_013697.1 6323626 854993 complement(241989..243029) 1 NC_001145.2 Taf11p; TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors 243029 TAF11 854993 TAF11 Saccharomyces cerevisiae TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors NP_013697.1 241989 R 4932 CDS NP_013698.1 6323627 854994 243225..244064 1 NC_001145.2 tRNA methyltransferase, catalyzes the esterification of modified uridine nucleotides in tRNAs, creating 5-methylcarbonylmethyluridine in tRNA(Arg3) and 5-methylcarbonylmethyl-2-thiouridine in tRNA(Glu); may have a role in stress response; Trm9p 244064 TRM9 854994 TRM9 Saccharomyces cerevisiae Trm9p NP_013698.1 243225 D 4932 CDS NP_013699.1 6323628 854995 244149..245903 1 NC_001145.2 Ubx2p; Protein involved in ER-associated protein degradation; proposed to coordinate the assembly of proteins involved in ERAD; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain 245903 UBX2 854995 UBX2 Saccharomyces cerevisiae Protein involved in ER-associated protein degradation; proposed to coordinate the assembly of proteins involved in ERAD; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain NP_013699.1 244149 D 4932 CDS NP_013701.1 6323630 854997 246116..246751 1 NC_001145.2 Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport; Erv25p 246751 ERV25 854997 ERV25 Saccharomyces cerevisiae Erv25p NP_013701.1 246116 D 4932 CDS NP_013702.1 6323631 854998 complement(246895..247428) 1 NC_001145.2 Rad33p; Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus 247428 RAD33 854998 RAD33 Saccharomyces cerevisiae Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus NP_013702.1 246895 R 4932 CDS NP_013703.1 6323632 854999 247677..250868 1 NC_001145.2 Spt5p; Protein that forms a complex with Spt4p and mediates both activation and inhibition of transcription elongation; Spt4p-Spt5p complex also plays a role in pre-mRNA processing 250868 SPT5 854999 SPT5 Saccharomyces cerevisiae Protein that forms a complex with Spt4p and mediates both activation and inhibition of transcription elongation; Spt4p-Spt5p complex also plays a role in pre-mRNA processing NP_013703.1 247677 D 4932 CDS NP_013705.1 6323634 855002 complement(251304..251516) 1 NC_001145.2 Mrpl39p; Mitochondrial ribosomal protein of the large subunit 251516 MRPL39 855002 MRPL39 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit NP_013705.1 251304 R 4932 CDS NP_013706.1 6323635 855003 complement(251839..252990) 1 NC_001145.2 Erg6p; Delta(24)-sterol C-methyltransferase, converts zymosterol to fecosterol in the ergosterol biosynthetic pathway by methylating position C-24; localized to both lipid particles and mitochondrial outer membrane 252990 ERG6 855003 ERG6 Saccharomyces cerevisiae Delta(24)-sterol C-methyltransferase, converts zymosterol to fecosterol in the ergosterol biosynthetic pathway by methylating position C-24; localized to both lipid particles and mitochondrial outer membrane NP_013706.1 251839 R 4932 CDS NP_076904.1 13129182 855004 complement(253162..253272) 1 NC_001145.2 Yml007c-ap; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria 253272 855004 YML007C-A Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria NP_076904.1 253162 R 4932 CDS NP_013707.1 6323636 855005 253848..255800 1 NC_001145.2 Yap1p; Basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; mediates resistance to cadmium 255800 YAP1 855005 YAP1 Saccharomyces cerevisiae Basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; mediates resistance to cadmium NP_013707.1 253848 D 4932 CDS NP_013708.1 6323637 855006 complement(256092..258416) 1 NC_001145.2 Gis4p; CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway 258416 GIS4 855006 GIS4 Saccharomyces cerevisiae CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway NP_013708.1 256092 R 4932 CDS NP_013709.1 6323638 855008 260221..261609 1 NC_001145.2 Trm12p; S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA 261609 TRM12 855008 TRM12 Saccharomyces cerevisiae S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA NP_013709.1 260221 D 4932 CDS NP_013710.1 6323639 855009 complement(261705..262685) 1 NC_001145.2 Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress; Glo1p 262685 GLO1 855009 GLO1 Saccharomyces cerevisiae Glo1p NP_013710.1 261705 R 4932 CDS NP_013711.1 6323640 855010 263483..264355 1 NC_001145.2 Yml003wp; Putative protein of unknown function 264355 855010 YML003W Saccharomyces cerevisiae Putative protein of unknown function NP_013711.1 263483 D 4932 CDS NP_013712.1 6323641 855011 264541..266754 1 NC_001145.2 Yml002wp; Putative protein of unknown function; expression induced by heat and by calcium shortage 266754 855011 YML002W Saccharomyces cerevisiae Putative protein of unknown function; expression induced by heat and by calcium shortage NP_013712.1 264541 D 4932 CDS NP_013713.1 6323642 855012 267174..267800 1 NC_001145.2 Ypt7p; GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion, similar to mammalian Rab7 267800 YPT7 855012 YPT7 Saccharomyces cerevisiae GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion, similar to mammalian Rab7 NP_013713.1 267174 D 4932 CDS NP_013714.1 6323643 855013 complement(269019..271136) 1 NC_001145.2 Polo-like kinase with similarity to Xenopus Plx1 and S. pombe Plo1p; found at bud neck, nucleus and SPBs; has multiple functions in mitosis and cytokinesis through phosphorylation of substrates; may be a Cdc28p substrate; Cdc5p 271136 CDC5 855013 CDC5 Saccharomyces cerevisiae Cdc5p NP_013714.1 269019 R 4932 CDS NP_878140.1 33438852 1466498 complement(271347..271577) 1 NC_001145.2 Ymr001c-ap; Putative protein of unknown function 271577 1466498 YMR001C-A Saccharomyces cerevisiae Putative protein of unknown function NP_878140.1 271347 R 4932 CDS NP_013715.1 6323644 855014 272193..272663 1 NC_001145.2 Mitochondrial intermembrane space cysteine motif protein; MIC17 is not an essential gene; Mic17p 272663 MIC17 855014 MIC17 Saccharomyces cerevisiae Mic17p NP_013715.1 272193 D 4932 CDS NP_013716.1 6323645 855015 273118..273714 1 NC_001145.2 Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media; Aim34p 273714 AIM34 855015 AIM34 Saccharomyces cerevisiae Aim34p NP_013716.1 273118 D 4932 CDS NP_013717.1 6323646 855016 274017..275552 1 NC_001145.2 Protein required for sorting proteins to the vacuole; overproduction of Mvp1p suppresses several dominant VPS1 mutations; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; Mvp1p 275552 MVP1 855016 MVP1 Saccharomyces cerevisiae Mvp1p NP_013717.1 274017 D 4932 CDS NP_013718.1 6323647 855017 276045..277211 1 NC_001145.2 Taf4p; TFIID subunit (48 kDa), involved in RNA polymerase II transcription initiation; potential Cdc28p substrate 277211 TAF4 855017 TAF4 Saccharomyces cerevisiae TFIID subunit (48 kDa), involved in RNA polymerase II transcription initiation; potential Cdc28p substrate NP_013718.1 276045 D 4932 CDS NP_013719.1 6323648 855018 complement(277561..279681) 1 NC_001145.2 Plb2p; Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine 279681 PLB2 855018 PLB2 Saccharomyces cerevisiae Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine NP_013719.1 277561 R 4932 CDS NP_013721.1 6323650 855020 complement(280590..282584) 1 NC_001145.2 Plb1p; Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol 282584 PLB1 855020 PLB1 Saccharomyces cerevisiae Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol NP_013721.1 280590 R 4932 CDS NP_013722.1 6323651 855021 284101..284640 1 NC_001145.2 Adi1p; Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions 284640 ADI1 855021 ADI1 Saccharomyces cerevisiae Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions NP_013722.1 284101 D 4932 CDS NP_013723.1 6323652 855022 285099..286316 1 NC_001145.2 Ymr010wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR010W is not an essential gene; YMR010W mRNA is transcribed with ADI1 286316 855022 YMR010W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR010W is not an essential gene; YMR010W mRNA is transcribed with ADI1 NP_013723.1 285099 D 4932 CDS NP_013724.1 6323653 855023 288078..289703 1 NC_001145.2 Hxt2p; High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose 289703 HXT2 855023 HXT2 Saccharomyces cerevisiae High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose NP_013724.1 288078 D 4932 CDS NP_013725.1 6323654 855025 291133..294966 1 NC_001145.2 eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant; Clu1p 294966 CLU1 855025 CLU1 Saccharomyces cerevisiae Clu1p NP_013725.1 291133 D 4932 CDS NP_013726.1 6323655 855026 complement(295178..296737) 1 NC_001145.2 Sec59p; Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation 296737 SEC59 855026 SEC59 Saccharomyces cerevisiae Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation NP_013726.1 295178 R 4932 CDS NP_013727.1 6323656 855028 298867..300426 1 NC_001145.2 Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; Bud22p 300426 BUD22 855028 BUD22 Saccharomyces cerevisiae Bud22p NP_013727.1 298867 D 4932 CDS NP_013728.1 6323657 855029 complement(300868..302484) 1 NC_001145.2 Erg5p; C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs 302484 ERG5 855029 ERG5 Saccharomyces cerevisiae C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs NP_013728.1 300868 R 4932 CDS NP_013729.1 6323658 855030 complement(303235..305592) 1 NC_001145.2 Sok2p; Nuclear protein that plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; negatively regulates pseudohyphal differentiation; homologous to several transcription factors 305592 SOK2 855030 SOK2 Saccharomyces cerevisiae Nuclear protein that plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; negatively regulates pseudohyphal differentiation; homologous to several transcription factors NP_013729.1 303235 R 4932 CDS NP_013730.1 6323659 855031 307488..308681 1 NC_001145.2 Spo20p; Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog 308681 SPO20 855031 SPO20 Saccharomyces cerevisiae Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog NP_013730.1 307488 D 4932 CDS NP_013731.1 6323660 855032 310207..311751 1 NC_001145.2 Ymr018wp; Putative protein of unknown function with similarity to human PEX5Rp (peroxin protein 5 related protein); transcription increases during colony development similar to genes involved in peroxisome biogenesis; YMR018W is not an essential gene 311751 855032 YMR018W Saccharomyces cerevisiae Putative protein of unknown function with similarity to human PEX5Rp (peroxin protein 5 related protein); transcription increases during colony development similar to genes involved in peroxisome biogenesis; YMR018W is not an essential gene NP_013731.1 310207 D 4932 CDS NP_013732.1 6323661 855033 312155..315004 1 NC_001145.2 Stb4p; Protein that binds Sin3p in a two-hybrid assay; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins 315004 STB4 855033 STB4 Saccharomyces cerevisiae Protein that binds Sin3p in a two-hybrid assay; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins NP_013732.1 312155 D 4932 CDS NP_013733.1 6323662 855034 315376..316902 1 NC_001145.2 Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis; Fms1p 316902 FMS1 855034 FMS1 Saccharomyces cerevisiae Fms1p NP_013733.1 315376 D 4932 CDS NP_013734.1 6323663 855035 complement(317164..318417) 1 NC_001145.2 Mac1p; Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport 318417 MAC1 855035 MAC1 Saccharomyces cerevisiae Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport NP_013734.1 317164 R 4932 CDS NP_013735.1 6323664 855036 318679..319176 1 NC_001145.2 Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly; Ubc7p 319176 UBC7 855036 UBC7 Saccharomyces cerevisiae Ubc7p NP_013735.1 318679 D 4932 CDS NP_013736.1 6323665 855037 complement(319436..321016) 1 NC_001145.2 Mss1p; Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3 321016 MSS1 855037 MSS1 Saccharomyces cerevisiae Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3 NP_013736.1 319436 R 4932 CDS NP_013737.1 6323666 855039 321874..323046 1 NC_001145.2 Mrpl3p; Mitochondrial ribosomal protein of the large subunit 323046 MRPL3 855039 MRPL3 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit NP_013737.1 321874 D 4932 CDS NP_013738.1 6323667 855040 323299..324186 1 NC_001145.2 Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; Csi1p 324186 CSI1 855040 CSI1 Saccharomyces cerevisiae Csi1p NP_013738.1 323299 D 4932 CDS NP_013739.1 6323668 855041 complement(324235..325434) 1 NC_001145.2 Pex12p; C3HC4-type RING-finger peroxisomal membrane peroxin required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorders 325434 PEX12 855041 PEX12 Saccharomyces cerevisiae C3HC4-type RING-finger peroxisomal membrane peroxin required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorders NP_013739.1 324235 R 4932 CDS NP_013740.1 6323669 855042 325876..327288 1 NC_001145.2 Ymr027wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene 327288 855042 YMR027W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene NP_013740.1 325876 D 4932 CDS NP_013741.1 6323670 855043 327481..328581 1 NC_001145.2 Tap42p; Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits 328581 TAP42 855043 TAP42 Saccharomyces cerevisiae Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits NP_013741.1 327481 D 4932 CDS NP_013742.1 6323671 855044 complement(328659..330230) 1 NC_001145.2 Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p; Far8p 330230 FAR8 855044 FAR8 Saccharomyces cerevisiae Far8p NP_013742.1 328659 R 4932 CDS NP_013743.1 6323672 855045 330792..331922 1 NC_001145.2 Rsf1p; Protein required for respiratory growth; localized to both the nucleus and mitochondrion; mutant displays decreased transcription of specific nuclear and mitochondrial genes whose products are involved in respiratory growth 331922 RSF1 855045 RSF1 Saccharomyces cerevisiae Protein required for respiratory growth; localized to both the nucleus and mitochondrion; mutant displays decreased transcription of specific nuclear and mitochondrial genes whose products are involved in respiratory growth NP_013743.1 330792 D 4932 CDS NP_013744.1 6323674 855047 complement(332211..334742) 1 NC_001145.2 Ymr031cp; Protein of unknown function with similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; YMR031C is not an essential gene 334742 855047 YMR031C Saccharomyces cerevisiae Protein of unknown function with similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; YMR031C is not an essential gene NP_013744.1 332211 R 4932 CDS NP_013746.1 6323675 855048 335297..337306 1 NC_001145.2 Hof1p; Bud neck-localized, SH3 domain-containing protein required for cytokinesis; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p 337306 HOF1 855048 HOF1 Saccharomyces cerevisiae Bud neck-localized, SH3 domain-containing protein required for cytokinesis; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p NP_013746.1 335297 D 4932 CDS NP_878141.1 33438853 1466499 337312..337602 1 NC_001145.2 Ymr030w-ap; Putative protein of unknown function 337602 1466499 YMR030W-A Saccharomyces cerevisiae Putative protein of unknown function NP_878141.1 337312 D 4932 CDS NP_013747.1 6323676 855049 join(337787..337816,337903..339276) 1 NC_001145.2 Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation; Arp9p 339276 ARP9 855049 ARP9 Saccharomyces cerevisiae Arp9p NP_013747.1 337787 D 4932 CDS NP_013748.1 6323677 855050 complement(339417..340721) 1 NC_001145.2 Ymr034cp; Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene 340721 855050 YMR034C Saccharomyces cerevisiae Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene NP_013748.1 339417 R 4932 CDS NP_013749.1 6323678 855051 341141..341674 1 NC_001145.2 Imp2p; Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p 341674 IMP2 855051 IMP2 Saccharomyces cerevisiae Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p NP_013749.1 341141 D 4932 CDS NP_013750.1 6323679 855052 complement(341855..343519) 1 NC_001145.2 Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25; Mih1p 343519 MIH1 855052 MIH1 Saccharomyces cerevisiae Mih1p NP_013750.1 341855 R 4932 CDS NP_013751.1 6323680 855053 complement(344402..346516) 1 NC_001145.2 Transcriptional activator related to Msn4p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; Msn2p 346516 MSN2 855053 MSN2 Saccharomyces cerevisiae Msn2p NP_013751.1 344402 R 4932 CDS NP_013752.1 6323681 855054 complement(347510..348259) 1 NC_001145.2 Copper chaperone for superoxide dismutase Sod1p, involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; Ccs1p 348259 CCS1 855054 CCS1 Saccharomyces cerevisiae Ccs1p NP_013752.1 347510 R 4932 CDS NP_013753.1 6323682 855055 complement(348643..349521) 1 NC_001145.2 Transcriptional coactivator, facilitates elongation by influencing enzymes that modify RNAP II, acts in a peroxide resistance pathway involving Rad2p; suppressor of TFIIB mutations; Sub1p 349521 SUB1 855055 SUB1 Saccharomyces cerevisiae Sub1p NP_013753.1 348643 R 4932 CDS NP_013754.1 6323683 855056 350380..350862 1 NC_001145.2 Yet2p; Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein 350862 YET2 855056 YET2 Saccharomyces cerevisiae Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein NP_013754.1 350380 D 4932 CDS NP_013755.1 6323684 855057 complement(350965..351972) 1 NC_001145.2 NAD-dependent arabinose dehydrogenase, involved in biosynthesis of erythroascorbic acid; similar to plant L-galactose dehydrogenase; Ara2p 351972 ARA2 855057 ARA2 Saccharomyces cerevisiae Ara2p NP_013755.1 350965 R 4932 CDS NP_013756.1 6323685 855059 352602..353135 1 NC_001145.2 Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p; Arg80p 353135 ARG80 855059 ARG80 Saccharomyces cerevisiae Arg80p NP_013756.1 352602 D 4932 CDS NP_013757.1 6323686 855060 353870..354730 1 NC_001145.2 Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes; Mcm1p 354730 MCM1 855060 MCM1 Saccharomyces cerevisiae Mcm1p NP_013757.1 353870 D 4932 CDS NP_013758.1 6323687 855061 355383..356810 1 NC_001145.2 Member of a complex (Isw1b) with Isw1p and Ioc2p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PWWP motif; Ioc4p 356810 IOC4 855061 IOC4 Saccharomyces cerevisiae Ioc4p NP_013758.1 355383 D 4932 CDS NP_013759.1 6323688 855062 complement(join(357358..361320,361322..362626)) 1 NC_001145.2 Ymr045cp; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 362626 855062 YMR045C Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_013759.1 357358 R 4932 CDS NP_013760.1 6323689 855063 complement(361304..362626) 1 NC_001145.2 Ymr046cp; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 362626 855063 YMR046C Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_013760.1 361304 R 4932 CDS NP_013762.1 6323691 855066 complement(363363..366704) 1 NC_001145.2 Subunit of the nuclear pore complex (NPC) that is localized to both sides of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup100p; Nup116p 366704 NUP116 855066 NUP116 Saccharomyces cerevisiae Nup116p NP_013762.1 363363 R 4932 CDS NP_013763.1 6323692 855067 366980..367933 1 NC_001145.2 Protein required for accurate chromosome segregation during meiosis; Csm3p 367933 CSM3 855067 CSM3 Saccharomyces cerevisiae Csm3p NP_013763.1 366980 D 4932 CDS NP_013764.1 6323693 855068 complement(368093..370516) 1 NC_001145.2 Protein required for maturation of the 25S and 5.8S ribosomal RNAs; constituent of 66S pre-ribosomal particles; homologous to mammalian Bop1; Erb1p 370516 ERB1 855068 ERB1 Saccharomyces cerevisiae Erb1p NP_013764.1 368093 R 4932 CDS NP_013765.1 6323694 855070 complement(join(373056..377018,377020..378324)) 1 NC_001145.2 Ymr050cp; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 378324 855070 YMR050C Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_013765.1 373056 R 4932 CDS NP_013766.1 6323695 855071 complement(377002..378324) 1 NC_001145.2 Ymr051cp; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 378324 855071 YMR051C Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_013766.1 377002 R 4932 CDS NP_013767.1 6323696 855073 379585..380199 1 NC_001145.2 Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; Far3p 380199 FAR3 855073 FAR3 Saccharomyces cerevisiae Far3p NP_013767.1 379585 D 4932 CDS NP_013769.1 6323698 855075 complement(380345..382897) 1 NC_001145.2 Stb2p; Protein that interacts with Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p 382897 STB2 855075 STB2 Saccharomyces cerevisiae Protein that interacts with Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p NP_013769.1 380345 R 4932 CDS NP_013770.1 6323699 855076 383302..385974 1 NC_001145.2 Subunit a of the vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole; Stv1p 385974 STV1 855076 STV1 Saccharomyces cerevisiae Stv1p NP_013770.1 383302 D 4932 CDS NP_013771.1 6323700 855077 complement(386100..387020) 1 NC_001145.2 Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage; Bub2p 387020 BUB2 855077 BUB2 Saccharomyces cerevisiae Bub2p NP_013771.1 386100 R 4932 CDS NP_013772.1 6323701 855078 complement(387314..388243) 1 NC_001145.2 Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator; Aac1p 388243 AAC1 855078 AAC1 Saccharomyces cerevisiae Aac1p NP_013772.1 387314 R 4932 CDS NP_013774.1 6323703 855080 388821..390731 1 NC_001145.2 Fet3p; Ferro-O2-oxidoreductase required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases 390731 FET3 855080 FET3 Saccharomyces cerevisiae Ferro-O2-oxidoreductase required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases NP_013774.1 388821 D 4932 CDS NP_013775.2 99030929 855081 391098..391484 1 NC_001145.2 Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen15p 391484 SEN15 855081 SEN15 Saccharomyces cerevisiae Sen15p NP_013775.2 391098 D 4932 CDS NP_013776.1 6323705 855082 complement(391531..392514) 1 NC_001145.2 Sam37p; Component of the mitochondrial outer membrane sorting and assembly machinery (SAM) complex; required for the sorting of some proteins to the outer membrane after import by the TOM complex 392514 SAM37 855082 SAM37 Saccharomyces cerevisiae Component of the mitochondrial outer membrane sorting and assembly machinery (SAM) complex; required for the sorting of some proteins to the outer membrane after import by the TOM complex NP_013776.1 391531 R 4932 CDS NP_013777.1 6323706 855083 392754..394787 1 NC_001145.2 Rna14p; Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex 394787 RNA14 855083 RNA14 Saccharomyces cerevisiae Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex NP_013777.1 392754 D 4932 CDS NP_013778.1 6323707 855084 complement(395053..396378) 1 NC_001145.2 Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine; Ecm40p 396378 ECM40 855084 ECM40 Saccharomyces cerevisiae Ecm40p NP_013778.1 395053 R 4932 CDS NP_013779.1 6323708 855085 397076..397795 1 NC_001145.2 Rim9p; Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalI; putative membrane protein 397795 RIM9 855085 RIM9 Saccharomyces cerevisiae Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalI; putative membrane protein NP_013779.1 397076 D 4932 CDS NP_013780.1 6323709 855086 397902..399458 1 NC_001145.2 Protein required for expression of the mitochondrial OLI1 gene encoding subunit 9 of F1-F0 ATP synthase; Aep1p 399458 AEP1 855086 AEP1 Saccharomyces cerevisiae Aep1p NP_013780.1 397902 D 4932 CDS NP_013781.1 6323710 855087 399701..401215 1 NC_001145.2 Protein required for nuclear membrane fusion during karyogamy, localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; expression of the gene is regulated by pheromone; Kar5p 401215 KAR5 855087 KAR5 Saccharomyces cerevisiae Kar5p NP_013781.1 399701 D 4932 CDS NP_013782.1 6323711 855088 401540..404236 1 NC_001145.2 Sov1p; Mitochondrial protein of unknown function 404236 SOV1 855088 SOV1 Saccharomyces cerevisiae Mitochondrial protein of unknown function NP_013782.1 401540 D 4932 CDS NP_013783.1 6323712 855089 complement(404322..405572) 1 NC_001145.2 Ubx4p; UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p 405572 UBX4 855089 UBX4 Saccharomyces cerevisiae UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p NP_013783.1 404322 R 4932 CDS NP_013784.1 6323713 855090 406303..407583 1 NC_001145.2 Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth; Avo2p 407583 AVO2 855090 AVO2 Saccharomyces cerevisiae Avo2p NP_013784.1 406303 D 4932 CDS NP_013785.1 6323714 855091 407708..408565 1 NC_001145.2 Nat4p; N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2A 408565 NAT4 855091 NAT4 Saccharomyces cerevisiae N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2A NP_013785.1 407708 D 4932 CDS NP_013786.1 6323715 855092 409153..410625 1 NC_001145.2 Nuclear transcription factor with two Cys2-His2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes; Mot3p 410625 MOT3 855092 MOT3 Saccharomyces cerevisiae Mot3p NP_013786.1 409153 D 4932 CDS NP_013787.1 6323716 855093 complement(410761..411264) 1 NC_001145.2 Tvp18p; Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments 411264 TVP18 855093 TVP18 Saccharomyces cerevisiae Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments NP_013787.1 410761 R 4932 CDS NP_013788.1 6323717 855094 411568..412119 1 NC_001145.2 Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation; Abf2p 412119 ABF2 855094 ABF2 Saccharomyces cerevisiae Abf2p NP_013788.1 411568 D 4932 CDS NP_013789.1 6323718 855095 complement(412267..412872) 1 NC_001145.2 Putative protein of unknown function; proposed to be involved in resistance to carboplatin and cisplatin; shares similarity to a human cytochrome oxidoreductase; null mutant displays increased levels of spontaneous Rad52 foci; Irc21p 412872 IRC21 855095 IRC21 Saccharomyces cerevisiae Irc21p NP_013789.1 412267 R 4932 CDS NP_013790.1 6323719 855096 complement(413035..413472) 1 NC_001145.2 Ymr074cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR074C is not an essential gene 413472 855096 YMR074C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR074C is not an essential gene NP_013790.1 413035 R 4932 CDS NP_013791.1 6323720 855097 413981..416035 1 NC_001145.2 Rco1p; Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p 416035 RCO1 855097 RCO1 Saccharomyces cerevisiae Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p NP_013791.1 413981 D 4932 CDS NP_013793.1 6323722 855099 complement(416195..420028) 1 NC_001145.2 Protein required for establishment and maintenance of sister chromatid condensation and cohesion, colocalizes with cohesin on chromosomes in an interdependent manner, may function as a protein-protein interaction scaffold; Pds5p 420028 PDS5 855099 PDS5 Saccharomyces cerevisiae Pds5p NP_013793.1 416195 R 4932 CDS NP_013794.1 6323723 855101 complement(421483..422148) 1 NC_001145.2 Vps20p; Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes 422148 VPS20 855101 VPS20 Saccharomyces cerevisiae Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes NP_013794.1 421483 R 4932 CDS NP_013795.1 6323724 855102 complement(422502..424727) 1 NC_001145.2 Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint; Ctf18p 424727 CTF18 855102 CTF18 Saccharomyces cerevisiae Ctf18p NP_013795.1 422502 R 4932 CDS NP_013796.1 6323725 855103 join(424988..424996,425153..426058) 1 NC_001145.2 Sec14p; Phosphatidylinositol/phosphatidylcholine transfer protein involved in coordinate regulation of PtdIns and PtdCho metabolism, products of which are regulators in Golgi to plasma membrane transport; functionally homologous to mammalian PITPs 426058 SEC14 855103 SEC14 Saccharomyces cerevisiae Phosphatidylinositol/phosphatidylcholine transfer protein involved in coordinate regulation of PtdIns and PtdCho metabolism, products of which are regulators in Golgi to plasma membrane transport; functionally homologous to mammalian PITPs NP_013796.1 424988 D 4932 CDS NP_013797.1 6323726 855104 complement(426711..429626) 1 NC_001145.2 Nam7p; ATP-dependent RNA helicase of the SFI superfamily, required for nonsense mediated mRNA decay and for efficient translation termination at nonsense codons; involved in telomere maintenance 429626 NAM7 855104 NAM7 Saccharomyces cerevisiae ATP-dependent RNA helicase of the SFI superfamily, required for nonsense mediated mRNA decay and for efficient translation termination at nonsense codons; involved in telomere maintenance NP_013797.1 426711 R 4932 CDS NP_013798.1 6323727 855105 complement(430078..431094) 1 NC_001145.2 Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant; Isf1p 431094 ISF1 855105 ISF1 Saccharomyces cerevisiae Isf1p NP_013798.1 430078 R 4932 CDS NP_013800.1 6323729 855107 434787..435914 1 NC_001145.2 Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production; Adh3p 435914 ADH3 855107 ADH3 Saccharomyces cerevisiae Adh3p NP_013800.1 434787 D 4932 CDS NP_013801.1 6323730 855108 436627..437415 1 NC_001145.2 Ymr084wp; Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains 437415 855108 YMR084W Saccharomyces cerevisiae Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains NP_013801.1 436627 D 4932 CDS NP_013802.1 6323731 855109 437490..438788 1 NC_001145.2 Ymr085wp; Putative protein of unknown function; YMR085W and adjacent ORF YMR084W are merged in related strains 438788 855109 YMR085W Saccharomyces cerevisiae Putative protein of unknown function; YMR085W and adjacent ORF YMR084W are merged in related strains NP_013802.1 437490 D 4932 CDS NP_013803.1 6323732 855110 439207..442089 1 NC_001145.2 Ymr086wp; Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; cAMP represses YMR086W expression 442089 855110 YMR086W Saccharomyces cerevisiae Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; cAMP represses YMR086W expression NP_013803.1 439207 D 4932 CDS NP_013805.1 6323734 855112 442526..443380 1 NC_001145.2 Ymr087wp; Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain 443380 855112 YMR087W Saccharomyces cerevisiae Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain NP_013805.1 442526 D 4932 CDS NP_013806.1 6323735 855113 complement(443413..445101) 1 NC_001145.2 Vba1p; Permease of basic amino acids in the vacuolar membrane 445101 VBA1 855113 VBA1 Saccharomyces cerevisiae Permease of basic amino acids in the vacuolar membrane NP_013806.1 443413 R 4932 CDS NP_013807.1 6323736 855114 complement(445608..448085) 1 NC_001145.2 Yta12p; Component, with Afg3p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes 448085 YTA12 855114 YTA12 Saccharomyces cerevisiae Component, with Afg3p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes NP_013807.1 445608 R 4932 CDS NP_013808.1 6323737 855115 449244..449927 1 NC_001145.2 Ymr090wp; Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR090W is not an essential gene 449927 855115 YMR090W Saccharomyces cerevisiae Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR090W is not an essential gene NP_013808.1 449244 D 4932 CDS NP_013809.1 6323738 855116 complement(450057..451364) 1 NC_001145.2 Npl6p; Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Ldb7p, and Htl1p to form a module important for a broad range of RSC functions; involved in nuclear protein import and maintenance of proper telomere length 451364 NPL6 855116 NPL6 Saccharomyces cerevisiae Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Ldb7p, and Htl1p to form a module important for a broad range of RSC functions; involved in nuclear protein import and maintenance of proper telomere length NP_013809.1 450057 R 4932 CDS NP_013810.1 6323739 855117 complement(451631..453478) 1 NC_001145.2 Aip1p; Actin cortical patch component, interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats 453478 AIP1 855117 AIP1 Saccharomyces cerevisiae Actin cortical patch component, interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats NP_013810.1 451631 R 4932 CDS NP_013811.1 6323740 855118 454014..455555 1 NC_001145.2 Utp15p; Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA 455555 UTP15 855118 UTP15 Saccharomyces cerevisiae Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA NP_013811.1 454014 D 4932 CDS NP_013812.1 6323741 855119 455824..457260 1 NC_001145.2 Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis; Ctf13p 457260 CTF13 855119 CTF13 Saccharomyces cerevisiae Ctf13p NP_013812.1 455824 D 4932 CDS NP_013813.1 6323742 855120 complement(457284..457958) 1 NC_001145.2 Sno1p; Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase 457958 SNO1 855120 SNO1 Saccharomyces cerevisiae Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase NP_013813.1 457284 R 4932 CDS NP_013814.1 6323743 855121 458407..459300 1 NC_001145.2 Snz1p; Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins 459300 SNZ1 855121 SNZ1 Saccharomyces cerevisiae Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins NP_013814.1 458407 D 4932 CDS NP_013815.1 6323744 855122 complement(459423..460526) 1 NC_001145.2 Peripheral GTPase of the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals; Mtg1p 460526 MTG1 855122 MTG1 Saccharomyces cerevisiae Mtg1p NP_013815.1 459423 R 4932 CDS NP_013816.1 6323745 855123 complement(460770..462608) 1 NC_001145.2 Protein of unknown function; non-tagged protein is detected in highly purified mitochondria; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media; Lrc4p 462608 LRC4 855123 LRC4 Saccharomyces cerevisiae Lrc4p NP_013816.1 460770 R 4932 CDS NP_013817.1 6323746 855125 complement(463933..464826) 1 NC_001145.2 Ymr099cp; Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS 464826 855125 YMR099C Saccharomyces cerevisiae Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS NP_013817.1 463933 R 4932 CDS NP_013818.1 6323747 855126 466299..468161 1 NC_001145.2 Protein of unknown function, deletion causes multi-budding phenotype; has similarity to Aspergillus nidulans samB gene; Mub1p 468161 MUB1 855126 MUB1 Saccharomyces cerevisiae Mub1p NP_013818.1 466299 D 4932 CDS NP_013819.1 6323748 855127 complement(468444..469475) 1 NC_001145.2 Srt1p; Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase 469475 SRT1 855127 SRT1 Saccharomyces cerevisiae Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase NP_013819.1 468444 R 4932 CDS NP_013820.1 6323749 855128 complement(469847..472351) 1 NC_001145.2 Ymr102cp; Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene 472351 855128 YMR102C Saccharomyces cerevisiae Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene NP_013820.1 469847 R 4932 CDS NP_013822.1 6323751 855130 complement(473419..475452) 1 NC_001145.2 Ypk2p; Protein kinase with similarityto serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK 475452 YPK2 855130 YPK2 Saccharomyces cerevisiae Protein kinase with similarityto serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK NP_013822.1 473419 R 4932 CDS NP_013823.1 6323752 855131 complement(475896..477605) 1 NC_001145.2 Phosphoglucomutase, catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; Pgm2p 477605 PGM2 855131 PGM2 Saccharomyces cerevisiae Pgm2p NP_013823.1 475896 R 4932 CDS NP_878142.1 33438854 1466500 478063..478257 1 NC_001145.2 Ymr105w-ap; Putative protein of unknown function 478257 1466500 YMR105W-A Saccharomyces cerevisiae Putative protein of unknown function NP_878142.1 478063 D 4932 CDS NP_013824.1 6323753 855132 complement(478300..480189) 1 NC_001145.2 Yku80p; Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair 480189 YKU80 855132 YKU80 Saccharomyces cerevisiae Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair NP_013824.1 478300 R 4932 CDS NP_013825.1 6323754 855134 483013..483360 1 NC_001145.2 Spg4p; Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources 483360 SPG4 855134 SPG4 Saccharomyces cerevisiae Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources NP_013825.1 483013 D 4932 CDS NP_013826.1 6323755 855135 484083..486146 1 NC_001145.2 Ilv2p; Acetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control 486146 ILV2 855135 ILV2 Saccharomyces cerevisiae Acetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control NP_013826.1 484083 D 4932 CDS NP_013827.1 6323756 855136 486586..490245 1 NC_001145.2 One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization; Myo5p 490245 MYO5 855136 MYO5 Saccharomyces cerevisiae Myo5p NP_013827.1 486586 D 4932 CDS NP_013828.1 6323757 855137 complement(490393..491991) 1 NC_001145.2 Putative fatty aldehyde dehydrogenase, located in the mitochondrial outer membrane and also in lipid particles; has similarity to human fatty aldehyde dehydrogenase (FALDH) which is implicated in Sjogren-Larsson syndrome; Hfd1p 491991 HFD1 855137 HFD1 Saccharomyces cerevisiae Hfd1p NP_013828.1 490393 R 4932 CDS NP_013829.1 6323758 855138 complement(492403..493791) 1 NC_001145.2 Ymr111cp; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene 493791 855138 YMR111C Saccharomyces cerevisiae Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene NP_013829.1 492403 R 4932 CDS NP_013830.1 6323759 855139 complement(494099..494494) 1 NC_001145.2 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein; Med11p 494494 MED11 855139 MED11 Saccharomyces cerevisiae Med11p NP_013830.1 494099 R 4932 CDS NP_013831.1 6323760 855140 494998..496281 1 NC_001145.2 Fol3p; Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis 496281 FOL3 855140 FOL3 Saccharomyces cerevisiae Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis NP_013831.1 494998 D 4932 CDS NP_013832.1 6323761 855141 complement(496342..497448) 1 NC_001145.2 Ymr114cp; Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene 497448 855141 YMR114C Saccharomyces cerevisiae Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene NP_013832.1 496342 R 4932 CDS NP_013833.1 6323762 855142 497703..499208 1 NC_001145.2 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Fmp24p 499208 FMP24 855142 FMP24 Saccharomyces cerevisiae Fmp24p NP_013833.1 497703 D 4932 CDS NP_013834.1 6323763 855143 complement(join(499455..499877,500151..500687)) 1 NC_001145.2 G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; represses Gcn4p in the absence of amino acid starvation; Asc1p 500687 ASC1 855143 ASC1 Saccharomyces cerevisiae Asc1p NP_013834.1 499455 R 4932 CDS NP_013835.1 6323764 855144 complement(501249..501890) 1 NC_001145.2 Spc24p; Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering 501890 SPC24 855144 SPC24 Saccharomyces cerevisiae Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering NP_013835.1 501249 R 4932 CDS NP_013836.1 6323765 855145 complement(502143..502733) 1 NC_001145.2 Ymr118cp; Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene 502733 855145 YMR118C Saccharomyces cerevisiae Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene NP_013836.1 502143 R 4932 CDS NP_013837.1 6323766 855147 505332..507206 1 NC_001145.2 Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals; Asi1p 507206 ASI1 855147 ASI1 Saccharomyces cerevisiae Asi1p NP_013837.1 505332 D 4932 CDS NP_013839.1 6323768 855149 complement(507501..509279) 1 NC_001145.2 Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade16p; ade16 ade17 mutants require adenine and histidine; Ade17p 509279 ADE17 855149 ADE17 Saccharomyces cerevisiae Ade17p NP_013839.1 507501 R 4932 CDS NP_013840.1 6323769 855150 complement(509733..510347) 1 NC_001145.2 Rpl15bp; Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Ap and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA 510347 RPL15B 855150 RPL15B Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Ap and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA NP_013840.1 509733 R 4932 CDS NP_061493.1 9755340 855152 511314..511568 1 NC_001145.2 Ymr122w-ap; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and endoplasmic reticulum 511568 855152 YMR122W-A Saccharomyces cerevisiae Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and endoplasmic reticulum NP_061493.1 511314 D 4932 CDS NP_013842.1 6323771 855153 513592..513960 1 NC_001145.2 V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); overproduction confers resistance to Pichia farinosa killer toxin; Pkr1p 513960 PKR1 855153 PKR1 Saccharomyces cerevisiae Pkr1p NP_013842.1 513592 D 4932 CDS NP_013843.1 6323772 855154 514455..517286 1 NC_001145.2 Ymr124wp; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene 517286 855154 YMR124W Saccharomyces cerevisiae Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene NP_013843.1 514455 D 4932 CDS NP_013844.2 6579194 855155 join(517538..517562,517885..520445) 1 NC_001145.2 Sto1p; Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80 520445 STO1 855155 STO1 Saccharomyces cerevisiae Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80 NP_013844.2 517538 D 4932 CDS NP_013845.1 6323774 855156 complement(520760..521788) 1 NC_001145.2 Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA); Dlt1p 521788 DLT1 855156 DLT1 Saccharomyces cerevisiae Dlt1p NP_013845.1 520760 R 4932 CDS NP_013846.1 6323775 855157 complement(522328..523344) 1 NC_001145.2 Sas2p; Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family 523344 SAS2 855157 SAS2 Saccharomyces cerevisiae Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family NP_013846.1 522328 R 4932 CDS NP_013847.1 6323776 855158 523695..527498 1 NC_001145.2 Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesis; Ecm16p 527498 ECM16 855158 ECM16 Saccharomyces cerevisiae Ecm16p NP_013847.1 523695 D 4932 CDS NP_013848.1 6323777 855159 527803..531816 1 NC_001145.2 Pom152p; Nuclear pore membrane glycoprotein; may be involved in duplication of nuclear pores and nuclear pore complexes during S-phase 531816 POM152 855159 POM152 Saccharomyces cerevisiae Nuclear pore membrane glycoprotein; may be involved in duplication of nuclear pores and nuclear pore complexes during S-phase NP_013848.1 527803 D 4932 CDS NP_013849.1 6323778 855160 532118..533026 1 NC_001145.2 Ymr130wp; Putative protein of unknown function; YMR130W is not an essential gene 533026 855160 YMR130W Saccharomyces cerevisiae Putative protein of unknown function; YMR130W is not an essential gene NP_013849.1 532118 D 4932 CDS NP_013850.1 6323779 855161 complement(533162..534697) 1 NC_001145.2 Rrb1p; Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p 534697 RRB1 855161 RRB1 Saccharomyces cerevisiae Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p NP_013850.1 533162 R 4932 CDS NP_013851.1 6323780 855162 complement(534943..535569) 1 NC_001145.2 Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein); Jlp2p 535569 JLP2 855162 JLP2 Saccharomyces cerevisiae Jlp2p NP_013851.1 534943 R 4932 CDS NP_013852.1 6323781 855163 join(536206..537447,537564..537608) 1 NC_001145.2 Rec114p; Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division 537608 REC114 855163 REC114 Saccharomyces cerevisiae Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division NP_013852.1 536206 D 4932 CDS NP_013853.1 6323782 855164 537837..538550 1 NC_001145.2 Protein that binds to and regulates Erg25p; localized to the ER; null mutant is viable in a respiratory defective background; synthetic lethal with mmt1 and mmt2 mutations; highly conserved in ascomycetes; Erg29p 538550 ERG29 855164 ERG29 Saccharomyces cerevisiae Erg29p NP_013853.1 537837 D 4932 CDS NP_013854.1 6323784 855166 complement(538688..540055) 1 NC_001145.2 Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START; Gid8p 540055 GID8 855166 GID8 Saccharomyces cerevisiae Gid8p NP_013854.1 538688 R 4932 CDS NP_013856.1 6323785 855167 541198..542880 1 NC_001145.2 Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine; Gat2p 542880 GAT2 855167 GAT2 Saccharomyces cerevisiae Gat2p NP_013856.1 541198 D 4932 CDS NP_013857.1 6323786 855168 complement(542977..544962) 1 NC_001145.2 Required for a post-incision step in the repair of DNA single and double-strand breaks that result from interstrand crosslinks produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; Pso2p 544962 PSO2 855168 PSO2 Saccharomyces cerevisiae Pso2p NP_013857.1 542977 R 4932 CDS NP_013858.1 6323787 855169 545154..545729 1 NC_001145.2 GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; Cin4p 545729 CIN4 855169 CIN4 Saccharomyces cerevisiae Cin4p NP_013858.1 545154 D 4932 CDS NP_013859.1 6323788 855170 546124..547236 1 NC_001145.2 Rim11p; Protein kinase required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta 547236 RIM11 855170 RIM11 Saccharomyces cerevisiae Protein kinase required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta NP_013859.1 546124 D 4932 CDS NP_013860.1 6323789 855171 547713..549182 1 NC_001145.2 Sip5p; Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase 549182 SIP5 855171 SIP5 Saccharomyces cerevisiae Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase NP_013860.1 547713 D 4932 CDS NP_013862.1 6323791 855173 complement(join(550205..550800,551203..551206)) 1 NC_001145.2 Rpl13bp; Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Ap; not essential for viability; has similarity to rat L13 ribosomal protein 551206 RPL13B 855173 RPL13B Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Ap; not essential for viability; has similarity to rat L13 ribosomal protein NP_013862.1 550205 R 4932 CDS NP_013863.2 9755341 855174 join(551927..551950,552495..552902) 1 NC_001145.2 Rps16ap; Protein component of the small (40S) ribosomal subunit; identical to Rps16Bp and has similarity to E. coli S9 and rat S16 ribosomal proteins 552902 RPS16A 855174 RPS16A Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit; identical to Rps16Bp and has similarity to E. coli S9 and rat S16 ribosomal proteins NP_013863.2 551927 D 4932 CDS NP_013864.1 6323793 855175 553361..554389 1 NC_001145.2 Ymr144wp; Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene 554389 855175 YMR144W Saccharomyces cerevisiae Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene NP_013864.1 553361 D 4932 CDS NP_013865.1 6323794 855176 complement(554792..556474) 1 NC_001145.2 Nde1p; Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain 556474 NDE1 855176 NDE1 Saccharomyces cerevisiae Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain NP_013865.1 554792 R 4932 CDS NP_013866.1 6323795 855177 complement(557480..558523) 1 NC_001145.2 Tif34p; Subunit of the core complex of translation initiation factor 3(eIF3), which is essential for translation 558523 TIF34 855177 TIF34 Saccharomyces cerevisiae Subunit of the core complex of translation initiation factor 3(eIF3), which is essential for translation NP_013866.1 557480 R 4932 CDS NP_013867.1 6323796 855178 559198..559869 1 NC_001145.2 Ymr147wp; Putative protein of unknown function 559869 855178 YMR147W Saccharomyces cerevisiae Putative protein of unknown function NP_013867.1 559198 D 4932 CDS NP_013868.1 6323797 855179 560365..560811 1 NC_001145.2 Ymr148wp; Putative protein of unknown function; predicted to contain a transmembrane domain; YMR148W is not an essential gene 560811 855179 YMR148W Saccharomyces cerevisiae Putative protein of unknown function; predicted to contain a transmembrane domain; YMR148W is not an essential gene NP_013868.1 560365 D 4932 CDS NP_013869.1 6323798 855180 560995..561855 1 NC_001145.2 Swp1p; Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum 561855 SWP1 855180 SWP1 Saccharomyces cerevisiae Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum NP_013869.1 560995 D 4932 CDS NP_013870.1 6323800 855182 complement(561955..562527) 1 NC_001145.2 Imp1p; Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p 562527 IMP1 855182 IMP1 Saccharomyces cerevisiae Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p NP_013870.1 561955 R 4932 CDS NP_013872.1 6323801 855183 563095..564192 1 NC_001145.2 Yim1p; Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 564192 YIM1 855183 YIM1 Saccharomyces cerevisiae Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_013872.1 563095 D 4932 CDS NP_013873.1 6323802 855184 564434..565861 1 NC_001145.2 Subunit of the nuclear pore complex (NPC), interacts with karyopherin Kap121p or with Nup170p via overlapping regions of Nup53p, involved in activation of the spindle checkpoint mediated by the Mad1p-Mad2p complex; Nup53p 565861 NUP53 855184 NUP53 Saccharomyces cerevisiae Nup53p NP_013873.1 564434 D 4932 CDS NP_013875.1 6323804 855186 complement(565998..568181) 1 NC_001145.2 Rim13p; Calpain-like cysteine protease involved in proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans palB 568181 RIM13 855186 RIM13 Saccharomyces cerevisiae Calpain-like cysteine protease involved in proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans palB NP_013875.1 565998 R 4932 CDS NP_013876.1 6323805 855187 568550..570193 1 NC_001145.2 Ymr155wp; Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen 570193 855187 YMR155W Saccharomyces cerevisiae Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen NP_013876.1 568550 D 4932 CDS NP_013877.1 6323806 855188 complement(570299..571015) 1 NC_001145.2 Tpp1p; DNA 3'-phosphatase that functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; has similarity to the l-2-haloacid dehalogenase superfamily 571015 TPP1 855188 TPP1 Saccharomyces cerevisiae DNA 3'-phosphatase that functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; has similarity to the l-2-haloacid dehalogenase superfamily NP_013877.1 570299 R 4932 CDS NP_013878.1 6323807 855189 complement(571276..572043) 1 NC_001145.2 Protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays increased frequency of mitochondrial genome loss and reduced growth rate in minimal glycerol media; Aim36p 572043 AIM36 855189 AIM36 Saccharomyces cerevisiae Aim36p NP_013878.1 571276 R 4932 CDS NP_013879.1 6323808 855190 572247..572714 1 NC_001145.2 Mrps8p; Mitochondrial ribosomal protein of the small subunit 572714 MRPS8 855190 MRPS8 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the small subunit NP_013879.1 572247 D 4932 CDS NP_013880.1 6323809 855192 complement(573193..573330) 1 NC_001145.2 Ymr158c-ap; Putative protein of unknown function, may contain a lipid attachment site; YMR158C-A is not an essential gene 573330 855192 YMR158C-A Saccharomyces cerevisiae Putative protein of unknown function, may contain a lipid attachment site; YMR158C-A is not an essential gene NP_013880.1 573193 R 4932 CDS NP_013882.1 6323811 855194 complement(574475..574927) 1 NC_001145.2 Protein that interacts with the Atg12p-Atg5p conjugate during formation of the pre-autophagosomal structure; essential for autophagy; Atg16p 574927 ATG16 855194 ATG16 Saccharomyces cerevisiae Atg16p NP_013882.1 574475 R 4932 CDS NP_013883.1 6323812 855195 575065..577515 1 NC_001145.2 Ymr160wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; mutant has enhanced sensitivity to overexpression of mutant huntingtin; YMR160W is not an essential gene 577515 855195 YMR160W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; mutant has enhanced sensitivity to overexpression of mutant huntingtin; YMR160W is not an essential gene NP_013883.1 575065 D 4932 CDS NP_013884.1 6323813 855196 577717..578391 1 NC_001145.2 Hlj1p; Co-chaperone for Hsp40p, anchored in the ER membrane; with its homolog Hdj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ 578391 HLJ1 855196 HLJ1 Saccharomyces cerevisiae Co-chaperone for Hsp40p, anchored in the ER membrane; with its homolog Hdj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ NP_013884.1 577717 D 4932 CDS NP_013885.1 6323814 855197 complement(578950..583920) 1 NC_001145.2 Dnf3p; Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vessicles; localizes to the trans-Golgi network; likely involved in protein transport; type 4 P-type ATPase 583920 DNF3 855197 DNF3 Saccharomyces cerevisiae Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vessicles; localizes to the trans-Golgi network; likely involved in protein transport; type 4 P-type ATPase NP_013885.1 578950 R 4932 CDS NP_013886.1 6323815 855198 complement(584270..586387) 1 NC_001145.2 Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene; Inp2p 586387 INP2 855198 INP2 Saccharomyces cerevisiae Inp2p NP_013886.1 584270 R 4932 CDS NP_013887.1 6323816 855200 complement(587273..589549) 1 NC_001145.2 Transcription factor involved in regulation of invasive growth and starch degradation; controls the activation of MUC1 and STA2 in response to nutritional signals; Mss11p 589549 MSS11 855200 MSS11 Saccharomyces cerevisiae Mss11p NP_013887.1 587273 R 4932 CDS NP_013888.1 6323817 855201 complement(590039..592627) 1 NC_001145.2 Pah1p; Mg2+-dependent phosphatidate (PA) phosphatase, catalyzes the dephosphorylation of PA to yield diacylglycerol and Pi, responsible for de novo lipid synthesis; homologous to mammalian lipin 1 592627 PAH1 855201 PAH1 Saccharomyces cerevisiae Mg2+-dependent phosphatidate (PA) phosphatase, catalyzes the dephosphorylation of PA to yield diacylglycerol and Pi, responsible for de novo lipid synthesis; homologous to mammalian lipin 1 NP_013888.1 590039 R 4932 CDS NP_013889.1 6323818 855202 complement(593366..594472) 1 NC_001145.2 Ymr166cp; Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene 594472 855202 YMR166C Saccharomyces cerevisiae Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene NP_013889.1 593366 R 4932 CDS NP_013890.1 6323819 855203 594885..597194 1 NC_001145.2 Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer; Mlh1p 597194 MLH1 855203 MLH1 Saccharomyces cerevisiae Mlh1p NP_013890.1 594885 D 4932 CDS NP_013891.1 6323820 855204 complement(597331..599157) 1 NC_001145.2 Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain; Cep3p 599157 CEP3 855204 CEP3 Saccharomyces cerevisiae Cep3p NP_013891.1 597331 R 4932 CDS NP_013892.1 6323821 855205 complement(599351..600871) 1 NC_001145.2 Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose; Ald3p 600871 ALD3 855205 ALD3 Saccharomyces cerevisiae Ald3p NP_013892.1 599351 R 4932 CDS NP_013893.1 6323822 855206 complement(601561..603081) 1 NC_001145.2 Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p; Ald2p 603081 ALD2 855206 ALD2 Saccharomyces cerevisiae Ald2p NP_013893.1 601561 R 4932 CDS NP_013894.1 6323823 855207 complement(603867..605519) 1 NC_001145.2 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to endosomes; mRNA is targeted to the bud via the mRNA transport system involving She2p: YMR171C is not an essential gene; Ear1p 605519 EAR1 855207 EAR1 Saccharomyces cerevisiae Ear1p NP_013894.1 603867 R 4932 CDS NP_013895.1 6323824 855208 605980..608139 1 NC_001145.2 Transcription factor required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p; Hot1p 608139 HOT1 855208 HOT1 Saccharomyces cerevisiae Hot1p NP_013895.1 605980 D 4932 CDS NP_013897.1 6323826 855210 608688..609980 1 NC_001145.2 Ddr48p; DNA damage-responsive protein, expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS 609980 DDR48 855210 DDR48 Saccharomyces cerevisiae DNA damage-responsive protein, expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS NP_013897.1 608688 D 4932 CDS NP_013899.1 6323828 855212 complement(610158..610364) 1 NC_001145.2 Pai3p; Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact 610364 PAI3 855212 PAI3 Saccharomyces cerevisiae Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact NP_013899.1 610158 R 4932 CDS NP_013900.1 6323829 855213 611015..611254 1 NC_001145.2 Sip18p; Protein of unknown function whose expression is induced by osmotic stress 611254 SIP18 855213 SIP18 Saccharomyces cerevisiae Protein of unknown function whose expression is induced by osmotic stress NP_013900.1 611015 D 4932 CDS NP_878143.1 33438855 1466501 611313..611507 1 NC_001145.2 Ymr175w-ap; Putative protein of unknown function 611507 1466501 YMR175W-A Saccharomyces cerevisiae Putative protein of unknown function NP_878143.1 611313 D 4932 CDS NP_013901.1 6323830 855214 611739..615974 1 NC_001145.2 Non-essential protein of unknown function, contains ATP/GTP-binding site motif A; null mutant exhibits cellular volume up to four times greater than wild-type, also large drooping buds with elongated necks; Ecm5p 615974 ECM5 855214 ECM5 Saccharomyces cerevisiae Ecm5p NP_013901.1 611739 D 4932 CDS NP_013902.1 6323831 855215 616565..618097 1 NC_001145.2 Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p; Mmt1p 618097 MMT1 855215 MMT1 Saccharomyces cerevisiae Mmt1p NP_013902.1 616565 D 4932 CDS NP_013903.1 6323832 855216 618478..619302 1 NC_001145.2 Ymr178wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS; YMR178W is not an essential gene 619302 855216 YMR178W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS; YMR178W is not an essential gene NP_013903.1 618478 D 4932 CDS NP_013904.1 6323833 855217 619857..622133 1 NC_001145.2 Spt21p; Protein required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p; involved in telomere maintenance 622133 SPT21 855217 SPT21 Saccharomyces cerevisiae Protein required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p; involved in telomere maintenance NP_013904.1 619857 D 4932 CDS NP_013905.1 6323834 855218 complement(622250..623212) 1 NC_001145.2 RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm; Ctl1p 623212 CTL1 855218 CTL1 Saccharomyces cerevisiae Ctl1p NP_013905.1 622250 R 4932 CDS NP_013906.1 6323835 855219 complement(623615..624079) 1 NC_001145.2 Ymr181cp; Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); YMR181C is not an essential gene 624079 855219 YMR181C Saccharomyces cerevisiae Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); YMR181C is not an essential gene NP_013906.1 623615 R 4932 CDS NP_013907.1 6323836 855220 complement(624531..625166) 1 NC_001145.2 Rgm1p; Putative transcriptional repressor with proline-rich zinc fingers; overproduction impairs cell growth 625166 RGM1 855220 RGM1 Saccharomyces cerevisiae Putative transcriptional repressor with proline-rich zinc fingers; overproduction impairs cell growth NP_013907.1 624531 R 4932 CDS NP_878144.1 33438856 1466502 625810..625896 1 NC_001145.2 Ymr182w-ap; Putative protein of unknown function 625896 1466502 YMR182W-A Saccharomyces cerevisiae Putative protein of unknown function NP_878144.1 625810 D 4932 CDS NP_013908.1 6323837 855221 complement(626920..627807) 1 NC_001145.2 Sso2p; Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p 627807 SSO2 855221 SSO2 Saccharomyces cerevisiae Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p NP_013908.1 626920 R 4932 CDS NP_013909.1 6323838 855222 628188..628784 1 NC_001145.2 Protein of unknown function involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; Add37p 628784 ADD37 855222 ADD37 Saccharomyces cerevisiae Add37p NP_013909.1 628188 D 4932 CDS NP_013910.1 6323839 855223 629024..631969 1 NC_001145.2 Ymr185wp; Putative protein of unknown function; essential gene required for viability 631969 855223 YMR185W Saccharomyces cerevisiae Putative protein of unknown function; essential gene required for viability NP_013910.1 629024 D 4932 CDS NP_013911.1 6323840 855224 632354..634471 1 NC_001145.2 Hsc82p; Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock 634471 HSC82 855224 HSC82 Saccharomyces cerevisiae Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock NP_013911.1 632354 D 4932 CDS NP_013912.1 6323841 855225 complement(634688..635983) 1 NC_001145.2 Ymr187cp; Putative protein of unknown function; YMR187C is not an essential gene 635983 855225 YMR187C Saccharomyces cerevisiae Putative protein of unknown function; YMR187C is not an essential gene NP_013912.1 634688 R 4932 CDS NP_013913.1 6323842 855226 complement(636290..637003) 1 NC_001145.2 Mrps17p; Mitochondrial ribosomal protein of the small subunit 637003 MRPS17 855226 MRPS17 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the small subunit NP_013913.1 636290 R 4932 CDS NP_013914.1 6323843 855227 637499..640603 1 NC_001145.2 P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm; Gcv2p 640603 GCV2 855227 GCV2 Saccharomyces cerevisiae Gcv2p NP_013914.1 637499 D 4932 CDS NP_013915.1 6323844 855228 complement(640914..645257) 1 NC_001145.2 Sgs1p; Nucleolar DNA helicase of the RecQ family involved in maintenance of genome integrity, regulates chromosome synapsis and meiotic crossing over; has similarity to human BLM and WRN helicases implicated in Bloom and Werner syndromes 645257 SGS1 855228 SGS1 Saccharomyces cerevisiae Nucleolar DNA helicase of the RecQ family involved in maintenance of genome integrity, regulates chromosome synapsis and meiotic crossing over; has similarity to human BLM and WRN helicases implicated in Bloom and Werner syndromes NP_013915.1 640914 R 4932 CDS NP_013916.2 37362682 855229 645655..646776 1 NC_001145.2 Spg5p; Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources 646776 SPG5 855229 SPG5 Saccharomyces cerevisiae Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources NP_013916.2 645655 D 4932 CDS NP_013917.1 6323846 855230 647117..649279 1 NC_001145.2 Putative GTPase activating protein (GAP) that may have a role in polarized exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p; Gyl1p 649279 GYL1 855230 GYL1 Saccharomyces cerevisiae Gyl1p NP_013917.1 647117 D 4932 CDS NP_013918.1 6323847 855231 650035..650811 1 NC_001145.2 Mrpl24p; Mitochondrial ribosomal protein of the large subunit 650811 MRPL24 855231 MRPL24 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit NP_013918.1 650035 D 4932 CDS NP_013920.1 6323848 855232 join(651144..651159,651623..651909) 1 NC_001145.2 Rpl36ap; N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Bp and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA 651909 RPL36A 855232 RPL36A Saccharomyces cerevisiae N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Bp and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA NP_013920.1 651144 D 4932 CDS NP_878145.1 33438857 1466503 complement(join(652593..652774,652847..652886)) 1 NC_001145.2 Ymr194c-bp; Putative protein of unknown function 652886 1466503 YMR194C-B Saccharomyces cerevisiae Putative protein of unknown function NP_878145.1 652593 R 4932 CDS NP_013922.1 6323851 855235 654033..654416 1 NC_001145.2 Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation; Icy1p 654416 ICY1 855235 ICY1 Saccharomyces cerevisiae Icy1p NP_013922.1 654033 D 4932 CDS NP_013923.1 6323852 855236 655075..658341 1 NC_001145.2 Ymr196wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene 658341 855236 YMR196W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene NP_013923.1 655075 D 4932 CDS NP_013924.1 6323853 855237 complement(658544..659197) 1 NC_001145.2 Vti1p; Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways 659197 VTI1 855237 VTI1 Saccharomyces cerevisiae Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways NP_013924.1 658544 R 4932 CDS NP_013925.1 6323854 855238 659744..661528 1 NC_001145.2 Kinesin-associated protein required for both karyogamy and mitotic spindle organization, interacts stably and specifically with Kar3p and may function to target this kinesin to a specific cellular role; has similarity to Vik1p; Cik1p 661528 CIK1 855238 CIK1 Saccharomyces cerevisiae Cik1p NP_013925.1 659744 D 4932 CDS NP_013926.1 6323855 855239 662643..664283 1 NC_001145.2 G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p); Cln1p 664283 CLN1 855239 CLN1 Saccharomyces cerevisiae Cln1p NP_013926.1 662643 D 4932 CDS NP_013927.1 6323856 855240 664751..665521 1 NC_001145.2 Rot1p; Essential ER membrane protein; may be involved in protein folding; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations 665521 ROT1 855240 ROT1 Saccharomyces cerevisiae Essential ER membrane protein; may be involved in protein folding; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations NP_013927.1 664751 D 4932 CDS NP_013928.1 6323857 855241 complement(join(665844..666932,667017..667043)) 1 NC_001145.2 Rad14p; Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein 667043 RAD14 855241 RAD14 Saccharomyces cerevisiae Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein NP_013928.1 665844 R 4932 CDS NP_013929.1 6323858 855242 667536..668204 1 NC_001145.2 Erg2p; C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis 668204 ERG2 855242 ERG2 Saccharomyces cerevisiae C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis NP_013929.1 667536 D 4932 CDS NP_013930.1 6323859 855243 668491..669654 1 NC_001145.2 Tom40p; Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore 669654 TOM40 855243 TOM40 Saccharomyces cerevisiae Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore NP_013930.1 668491 D 4932 CDS NP_013931.1 6323860 855244 complement(670062..671324) 1 NC_001145.2 Peripheral membrane protein of peroxisomes involved in peroxisomal inheritance; Inp1p 671324 INP1 855244 INP1 Saccharomyces cerevisiae Inp1p NP_013931.1 670062 R 4932 CDS NP_013932.1 6323861 855245 complement(671886..674765) 1 NC_001145.2 Pfk2p; Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes 674765 PFK2 855245 PFK2 Saccharomyces cerevisiae Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes NP_013932.1 671886 R 4932 CDS NP_013933.1 6323862 855246 675895..676836 1 NC_001145.2 Ymr206wp; Putative protein of unknown function; YMR206W is not an essential gene 676836 855246 YMR206W Saccharomyces cerevisiae Putative protein of unknown function; YMR206W is not an essential gene NP_013933.1 675895 D 4932 CDS NP_013934.1 6323863 855247 complement(677192..683563) 1 NC_001145.2 Mitochondrial acetyl-coenzyme A carboxylase, catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis; Hfa1p 683563 HFA1 855247 HFA1 Saccharomyces cerevisiae Hfa1p NP_013934.1 677192 R 4932 CDS NP_013935.1 6323864 855248 684466..685797 1 NC_001145.2 Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate; Erg12p 685797 ERG12 855248 ERG12 Saccharomyces cerevisiae Erg12p NP_013935.1 684466 D 4932 CDS NP_013936.1 6323865 855249 complement(685910..687283) 1 NC_001145.2 Ymr209cp; Putative protein of unknown function; YMR209C is not an essential gene 687283 855249 YMR209C Saccharomyces cerevisiae Putative protein of unknown function; YMR209C is not an essential gene NP_013936.1 685910 R 4932 CDS NP_013937.1 6323866 855250 687515..688864 1 NC_001145.2 Ymr210wp; Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification 688864 855250 YMR210W Saccharomyces cerevisiae Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification NP_013937.1 687515 D 4932 CDS NP_013938.1 6323867 855251 689082..690509 1 NC_001145.2 Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family; Dml1p 690509 DML1 855251 DML1 Saccharomyces cerevisiae Dml1p NP_013938.1 689082 D 4932 CDS NP_013939.1 6323868 855252 complement(690694..693042) 1 NC_001145.2 Non-essential protein of unknown function; exhibits synthetic lethal genetic interactions with PHO85; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies and is phosphorylated; Efr3p 693042 EFR3 855252 EFR3 Saccharomyces cerevisiae Efr3p NP_013939.1 690694 R 4932 CDS NP_013940.1 6323869 855253 693380..695152 1 NC_001145.2 Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p; Cef1p 695152 CEF1 855253 CEF1 Saccharomyces cerevisiae Cef1p NP_013940.1 693380 D 4932 CDS NP_013941.2 37362683 855254 695349..696482 1 NC_001145.2 Scj1p; One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins 696482 SCJ1 855254 SCJ1 Saccharomyces cerevisiae One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins NP_013941.2 695349 D 4932 CDS NP_013942.1 6323871 855255 696795..698369 1 NC_001145.2 Putative 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall; Gas3p 698369 GAS3 855255 GAS3 Saccharomyces cerevisiae Gas3p NP_013942.1 696795 D 4932 CDS NP_013943.1 6323872 855256 complement(698810..701038) 1 NC_001145.2 Sky1p; SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1 701038 SKY1 855256 SKY1 Saccharomyces cerevisiae SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1 NP_013943.1 698810 R 4932 CDS NP_013944.1 6323873 855257 701789..703366 1 NC_001145.2 Gua1p; GMP synthase, an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation 703366 GUA1 855257 GUA1 Saccharomyces cerevisiae GMP synthase, an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation NP_013944.1 701789 D 4932 CDS NP_013945.1 6323874 855258 complement(703578..706886) 1 NC_001145.2 Trs130p; One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1 706886 TRS130 855258 TRS130 Saccharomyces cerevisiae One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1 NP_013945.1 703578 R 4932 CDS NP_013946.1 6323875 855259 707132..712108 1 NC_001145.2 Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p; Esc1p 712108 ESC1 855259 ESC1 Saccharomyces cerevisiae Esc1p NP_013946.1 707132 D 4932 CDS NP_013947.1 6323876 855260 712315..713670 1 NC_001145.2 Phosphomevalonate kinase, an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate; Erg8p 713670 ERG8 855260 ERG8 Saccharomyces cerevisiae Erg8p NP_013947.1 712315 D 4932 CDS NP_013948.1 6323877 855261 complement(713930..715444) 1 NC_001145.2 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Fmp42p 715444 FMP42 855261 FMP42 Saccharomyces cerevisiae Fmp42p NP_013948.1 713930 R 4932 CDS NP_013949.1 6323878 855262 complement(715637..716308) 1 NC_001145.2 Serine hydrolase that localizes to the cytoplasm; sequence is similar to Fsh1p and Fsh3p; Fsh2p 716308 FSH2 855262 FSH2 Saccharomyces cerevisiae Fsh2p NP_013949.1 715637 R 4932 CDS NP_013950.1 6323879 855263 716714..718129 1 NC_001145.2 Ubp8p; Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B 718129 UBP8 855263 UBP8 Saccharomyces cerevisiae Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B NP_013950.1 716714 D 4932 CDS NP_013951.1 6323880 855264 complement(718574..720652) 1 NC_001145.2 Subunit of a complex with Rad50p and Xrs2p (RMX complex) that functions in repair of DNA double-strand breaks and in telomere stability, exhibits nuclease activity that appears to be required for RMX function; widely conserved; Mre11p 720652 MRE11 855264 MRE11 Saccharomyces cerevisiae Mre11p NP_013951.1 718574 R 4932 CDS NP_013952.1 6323881 855265 complement(join(720959..721197,721345..721402)) 1 NC_001145.2 Mrpl44p; Mitochondrial ribosomal protein of the large subunit 721402 MRPL44 855265 MRPL44 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit NP_013952.1 720959 R 4932 CDS NP_013953.1 6323882 855266 complement(721592..722395) 1 NC_001145.2 Tma29p; NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments 722395 TMA29 855266 TMA29 Saccharomyces cerevisiae NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments NP_013953.1 721592 R 4932 CDS NP_013954.1 6323883 855267 complement(722612..724384) 1 NC_001145.2 Taf7p; TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation 724384 TAF7 855267 TAF7 Saccharomyces cerevisiae TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation NP_013954.1 722612 R 4932 CDS NP_013955.1 6323884 855268 724625..725650 1 NC_001145.2 Mtf1p; Mitochondrial RNA polymerase specificity factor with structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors, interacts with mitochondrial core polymerase Rpo41p 725650 MTF1 855268 MTF1 Saccharomyces cerevisiae Mitochondrial RNA polymerase specificity factor with structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors, interacts with mitochondrial core polymerase Rpo41p NP_013955.1 724625 D 4932 CDS NP_013956.1 6323885 855269 complement(725933..731122) 1 NC_001145.2 Rrp5p; Protein required for the synthesis of both 18S and 5.8S rRNA; C-terminal region is crucial for the formation of 18S rRNA and N-terminal region is required for the 5.8S rRNA; component of small ribosomal subunit (SSU) processosome 731122 RRP5 855269 RRP5 Saccharomyces cerevisiae Protein required for the synthesis of both 18S and 5.8S rRNA; C-terminal region is crucial for the formation of 18S rRNA and N-terminal region is required for the 5.8S rRNA; component of small ribosomal subunit (SSU) processosome NP_013956.1 725933 R 4932 CDS NP_013957.1 6323886 855270 join(732413..732464,732875..733140) 1 NC_001145.2 Rps10bp; Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Ap and has similarity to rat ribosomal protein S10 733140 RPS10B 855270 RPS10B Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Ap and has similarity to rat ribosomal protein S10 NP_013957.1 732413 D 4932 CDS NP_878146.1 33438858 1466504 733267..733455 1 NC_001145.2 Ymr230w-ap; Putative protein of unknown function 733455 1466504 YMR230W-A Saccharomyces cerevisiae Putative protein of unknown function NP_878146.1 733267 D 4932 CDS NP_013958.1 6323887 855271 733544..736633 1 NC_001145.2 Pep5p; Component of CORVET tethering complex; peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis; interacts with Pep7p 736633 PEP5 855271 PEP5 Saccharomyces cerevisiae Component of CORVET tethering complex; peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis; interacts with Pep7p NP_013958.1 733544 D 4932 CDS NP_013959.1 6323888 855272 736925..738958 1 NC_001145.2 Fus2p; Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before nuclear fusion during mating 738958 FUS2 855272 FUS2 Saccharomyces cerevisiae Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before nuclear fusion during mating NP_013959.1 736925 D 4932 CDS NP_013960.1 6323889 855273 739184..739864 1 NC_001145.2 Tri1p; Non-essential sumoylated protein of unknown function with similarity to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus 739864 TRI1 855273 TRI1 Saccharomyces cerevisiae Non-essential sumoylated protein of unknown function with similarity to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus NP_013960.1 739184 D 4932 CDS NP_013961.1 6323890 855274 740265..741311 1 NC_001145.2 Rnh1p; Ribonuclease H1, removes RNA primers during Okazaki fragment synthesis; degrades RNA attached to the 5'-end of a DNA strand 741311 RNH1 855274 RNH1 Saccharomyces cerevisiae Ribonuclease H1, removes RNA primers during Okazaki fragment synthesis; degrades RNA attached to the 5'-end of a DNA strand NP_013961.1 740265 D 4932 CDS NP_013962.1 6323891 855275 complement(741511..742734) 1 NC_001145.2 Rna1p; GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport 742734 RNA1 855275 RNA1 Saccharomyces cerevisiae GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport NP_013962.1 741511 R 4932 CDS NP_013963.1 6323892 855276 742970..743443 1 NC_001145.2 Taf9p; Subunit (17 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3 743443 TAF9 855276 TAF9 Saccharomyces cerevisiae Subunit (17 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3 NP_013963.1 742970 D 4932 CDS NP_013964.1 6323893 855277 743748..745922 1 NC_001145.2 Member of the ChAPs family (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; may interact with ribosomes; Bch1p 745922 BCH1 855277 BCH1 Saccharomyces cerevisiae Bch1p NP_013964.1 743748 D 4932 CDS NP_013965.1 6323894 855278 746352..747728 1 NC_001145.2 Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p; Dfg5p 747728 DFG5 855278 DFG5 Saccharomyces cerevisiae Dfg5p NP_013965.1 746352 D 4932 CDS NP_013966.1 6323895 855280 complement(748261..749676) 1 NC_001145.2 Rnt1p; RNAase III; involved in rDNA transcription and rRNA processing; also cleaves a stem-loop structure at the 3' end of U2 snRNA to ensure formation of the correct U2 3' end 749676 RNT1 855280 RNT1 Saccharomyces cerevisiae RNAase III; involved in rDNA transcription and rRNA processing; also cleaves a stem-loop structure at the 3' end of U2 snRNA to ensure formation of the correct U2 3' end NP_013966.1 748261 R 4932 CDS NP_013967.1 6323896 855281 complement(749929..751239) 1 NC_001145.2 Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p; Cus1p 751239 CUS1 855281 CUS1 Saccharomyces cerevisiae Cus1p NP_013967.1 749929 R 4932 CDS NP_013968.1 6323897 855282 751960..752904 1 NC_001145.2 Yhm2p; Mitochondrial DNA-binding protein, component of the mitochondrial nucleoid structure, involved in mtDNA replication and segregation of mitochondrial genomes; member of the mitochondrial carrier protein family 752904 YHM2 855282 YHM2 Saccharomyces cerevisiae Mitochondrial DNA-binding protein, component of the mitochondrial nucleoid structure, involved in mtDNA replication and segregation of mitochondrial genomes; member of the mitochondrial carrier protein family NP_013968.1 751960 D 4932 CDS NP_013969.3 154199621 855283 complement(join(753224..753741,754219)) 1 NC_001145.2 Rpl20ap; Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Bp and has similarity to rat L18a ribosomal protein 754219 RPL20A 855283 RPL20A Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Bp and has similarity to rat L18a ribosomal protein NP_013969.3 753224 R 4932 CDS NP_878147.1 33438859 1466505 754296..754385 1 NC_001145.2 Ymr242w-ap; Putative protein of unknown function 754385 1466505 YMR242W-A Saccharomyces cerevisiae Putative protein of unknown function NP_878147.1 754296 D 4932 CDS NP_013970.1 6323899 855284 complement(754837..756165) 1 NC_001145.2 Zrc1p; Vacuolar membrane zinc transporter, transports zinc from the cytosol into the vacuole for storage; also has a role in resistance to zinc shock resulting from a sudden influx of zinc into the cytoplasm 756165 ZRC1 855284 ZRC1 Saccharomyces cerevisiae Vacuolar membrane zinc transporter, transports zinc from the cytosol into the vacuole for storage; also has a role in resistance to zinc shock resulting from a sudden influx of zinc into the cytoplasm NP_013970.1 754837 R 4932 CDS NP_013971.1 6323900 855285 757249..758316 1 NC_001145.2 Ymr244wp; Putative protein of unknown function 758316 855285 YMR244W Saccharomyces cerevisiae Putative protein of unknown function NP_013971.1 757249 D 4932 CDS NP_013972.1 6323902 855287 complement(758516..758830) 1 NC_001145.2 Ymr244c-ap; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS; YMR244C-A is not an essential gene 758830 855287 YMR244C-A Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS; YMR244C-A is not an essential gene NP_013972.1 758516 R 4932 CDS NP_013974.1 6323903 855288 759806..761890 1 NC_001145.2 Long chain fatty acyl-CoA synthetase, regulates protein modification during growth in the presence of ethanol, functions to incorporate palmitic acid into phospholipids and neutral lipids; Faa4p 761890 FAA4 855288 FAA4 Saccharomyces cerevisiae Faa4p NP_013974.1 759806 D 4932 CDS NP_013975.1 6323904 855289 complement(763350..768038) 1 NC_001145.2 Rkr1p; Nuclear RING domain protein with functional connections to chromatin modification; may interact with ribosomes, based on co-purification experiments; YMR247C is not an essential gene 768038 RKR1 855289 RKR1 Saccharomyces cerevisiae Nuclear RING domain protein with functional connections to chromatin modification; may interact with ribosomes, based on co-purification experiments; YMR247C is not an essential gene NP_013975.1 763350 R 4932 CDS NP_878148.1 33438860 1466506 769282..769425 1 NC_001145.2 Ymr247w-ap; Putative protein of unknown function 769425 1466506 YMR247W-A Saccharomyces cerevisiae Putative protein of unknown function NP_878148.1 769282 D 4932 CDS NP_013976.1 6323905 855291 770800..772557 1 NC_001145.2 Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress; Gad1p 772557 GAD1 855291 GAD1 Saccharomyces cerevisiae Gad1p NP_013976.1 770800 D 4932 CDS NP_013977.1 6323906 855292 772914..774014 1 NC_001145.2 Omega class glutathione transferase; putative cytosolic localization; Gto3p 774014 GTO3 855292 GTO3 Saccharomyces cerevisiae Gto3p NP_013977.1 772914 D 4932 CDS NP_013978.1 6323907 855293 774751..774930 1 NC_001145.2 Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor; Hor7p 774930 HOR7 855293 HOR7 Saccharomyces cerevisiae Hor7p NP_013978.1 774751 D 4932 CDS NP_013979.1 6323908 855294 complement(775314..775718) 1 NC_001145.2 Ymr252cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR252C is not an essential gene 775718 855294 YMR252C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR252C is not an essential gene NP_013979.1 775314 R 4932 CDS NP_013980.1 6323909 855295 complement(775945..777189) 1 NC_001145.2 Ymr253cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene 777189 855295 YMR253C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene NP_013980.1 775945 R 4932 CDS NP_013982.1 6323911 855297 778000..778566 1 NC_001145.2 Gfd1p; Coiled-coiled protein of unknown function, identified as a high-copy suppressor of a dbp5 mutation 778566 GFD1 855297 GFD1 Saccharomyces cerevisiae Coiled-coiled protein of unknown function, identified as a high-copy suppressor of a dbp5 mutation NP_013982.1 778000 D 4932 CDS NP_013983.1 6323912 855298 complement(778944..779126) 1 NC_001145.2 Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; Cox7p 779126 COX7 855298 COX7 Saccharomyces cerevisiae Cox7p NP_013983.1 778944 R 4932 CDS NP_013984.1 6323913 855299 complement(779628..782030) 1 NC_001145.2 Pet111p; Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane 782030 PET111 855299 PET111 Saccharomyces cerevisiae Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane NP_013984.1 779628 R 4932 CDS NP_013985.1 6323914 855300 complement(782619..784280) 1 NC_001145.2 Ymr258cp; Protein of unknown function with similarity to F-box proteins; physically interacts with Skp1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR258C is not an essential gene 784280 855300 YMR258C Saccharomyces cerevisiae Protein of unknown function with similarity to F-box proteins; physically interacts with Skp1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR258C is not an essential gene NP_013985.1 782619 R 4932 CDS NP_013986.1 6323915 855301 complement(784620..788882) 1 NC_001145.2 Ymr259cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR259C is not an essential gene 788882 855301 YMR259C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR259C is not an essential gene NP_013986.1 784620 R 4932 CDS NP_013987.1 6323916 855302 complement(789377..789838) 1 NC_001145.2 Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3; Tif11p 789838 TIF11 855302 TIF11 Saccharomyces cerevisiae Tif11p NP_013987.1 789377 R 4932 CDS NP_013988.1 6323917 855303 complement(790204..793368) 1 NC_001145.2 Tps3p; Regulatory subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway 793368 TPS3 855303 TPS3 Saccharomyces cerevisiae Regulatory subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway NP_013988.1 790204 R 4932 CDS NP_013989.1 6323918 855304 793725..794666 1 NC_001145.2 Ymr262wp; Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene 794666 855304 YMR262W Saccharomyces cerevisiae Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene NP_013989.1 793725 D 4932 CDS NP_013990.1 6323919 855305 794918..795523 1 NC_001145.2 Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance; Sap30p 795523 SAP30 855305 SAP30 Saccharomyces cerevisiae Sap30p NP_013990.1 794918 D 4932 CDS NP_013991.1 6323920 855306 795804..796415 1 NC_001145.2 Endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination; Cue1p 796415 CUE1 855306 CUE1 Saccharomyces cerevisiae Cue1p NP_013991.1 795804 D 4932 CDS NP_013992.1 6323921 855307 complement(796539..797924) 1 NC_001145.2 Ymr265cp; Putative protein of unknown function 797924 855307 YMR265C Saccharomyces cerevisiae Putative protein of unknown function NP_013992.1 796539 R 4932 CDS NP_013993.1 6323922 855308 798517..801378 1 NC_001145.2 Rsn1p; Membrane protein of unknown function; overexpression suppresses NaCl sensitivity of sro7 mutant 801378 RSN1 855308 RSN1 Saccharomyces cerevisiae Membrane protein of unknown function; overexpression suppresses NaCl sensitivity of sro7 mutant NP_013993.1 798517 D 4932 CDS NP_013994.1 6323923 855309 801771..802703 1 NC_001145.2 Ppa2p; Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate 802703 PPA2 855309 PPA2 Saccharomyces cerevisiae Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate NP_013994.1 801771 D 4932 CDS NP_013995.1 6323924 855310 complement(802887..804221) 1 NC_001145.2 Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling; Prp24p 804221 PRP24 855310 PRP24 Saccharomyces cerevisiae Prp24p NP_013995.1 802887 R 4932 CDS NP_013996.2 44829555 855311 804455..805090 1 NC_001145.2 Tma23p; Nucleolar protein of unknown function implicated in ribosome biogenesis; TMA23 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes 805090 TMA23 855311 TMA23 Saccharomyces cerevisiae Nucleolar protein of unknown function implicated in ribosome biogenesis; TMA23 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes NP_013996.2 804455 D 4932 CDS NP_013997.1 6323926 855312 complement(805325..806422) 1 NC_001145.2 Rrn9p; Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I 806422 RRN9 855312 RRN9 Saccharomyces cerevisiae Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I NP_013997.1 805325 R 4932 CDS NP_013998.1 6323927 855313 complement(806864..807547) 1 NC_001145.2 Ura10p; One of two orotate phosphoribosyltransferase isozymes (see also URA5) that catalyze the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate 807547 URA10 855313 URA10 Saccharomyces cerevisiae One of two orotate phosphoribosyltransferase isozymes (see also URA5) that catalyze the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate NP_013998.1 806864 R 4932 CDS NP_013999.1 6323928 855315 complement(809622..810776) 1 NC_001145.2 Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth; Scs7p 810776 SCS7 855315 SCS7 Saccharomyces cerevisiae Scs7p NP_013999.1 809622 R 4932 CDS NP_878149.1 33438861 1466507 811088..811195 1 NC_001145.2 Ymr272w-bp; Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 811195 1466507 YMR272W-B Saccharomyces cerevisiae Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching NP_878149.1 811088 D 4932 CDS NP_014000.1 6323929 855316 complement(811232..813979) 1 NC_001145.2 Zds1p; Protein that interacts with silencing proteins at the telomere, involved in transcriptional silencing; has a role in localization of Bcy1p, a regulatory subunit of protein kinase A; implicated in mRNA nuclear export 813979 ZDS1 855316 ZDS1 Saccharomyces cerevisiae Protein that interacts with silencing proteins at the telomere, involved in transcriptional silencing; has a role in localization of Bcy1p, a regulatory subunit of protein kinase A; implicated in mRNA nuclear export NP_014000.1 811232 R 4932 CDS NP_014001.1 6323930 855317 complement(814363..815310) 1 NC_001145.2 Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone; Rce1p 815310 RCE1 855317 RCE1 Saccharomyces cerevisiae Rce1p NP_014001.1 814363 R 4932 CDS NP_014002.1 6323931 855318 complement(815650..818580) 1 NC_001145.2 Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex, functional homolog of Bul2p, disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases; Bul1p 818580 BUL1 855318 BUL1 Saccharomyces cerevisiae Bul1p NP_014002.1 815650 R 4932 CDS NP_014003.1 6323932 855319 818826..819947 1 NC_001145.2 Nuclear-enriched ubiquitin-like polyubiquitin-binding protein, required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle, involved in proteolysis, interacts with the proteasome; Dsk2p 819947 DSK2 855319 DSK2 Saccharomyces cerevisiae Dsk2p NP_014003.1 818826 D 4932 CDS NP_014004.1 6323933 855320 820255..822453 1 NC_001145.2 Fcp1p; Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p) 822453 FCP1 855320 FCP1 Saccharomyces cerevisiae Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p) NP_014004.1 820255 D 4932 CDS NP_014005.1 6323934 855321 822762..824630 1 NC_001145.2 Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential; Pgm3p 824630 PGM3 855321 PGM3 Saccharomyces cerevisiae Pgm3p NP_014005.1 822762 D 4932 CDS NP_014006.1 6323935 855322 complement(824728..826350) 1 NC_001145.2 Ymr279cp; Putative protein of unknown function; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene 826350 855322 YMR279C Saccharomyces cerevisiae Putative protein of unknown function; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene NP_014006.1 824728 R 4932 CDS NP_014007.1 6323936 855323 complement(827027..831328) 1 NC_001145.2 Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements; Cat8p 831328 CAT8 855323 CAT8 Saccharomyces cerevisiae Cat8p NP_014007.1 827027 R 4932 CDS NP_014008.1 6323937 855324 832338..833252 1 NC_001145.2 Gpi12p; ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp 833252 GPI12 855324 GPI12 Saccharomyces cerevisiae ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp NP_014008.1 832338 D 4932 CDS NP_014009.1 6323938 855325 complement(833355..835097) 1 NC_001145.2 Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader; Aep2p 835097 AEP2 855325 AEP2 Saccharomyces cerevisiae Aep2p NP_014009.1 833355 R 4932 CDS NP_014010.1 6323939 855326 complement(835325..836866) 1 NC_001145.2 Rit1p; 2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA 836866 RIT1 855326 RIT1 Saccharomyces cerevisiae 2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA NP_014010.1 835325 R 4932 CDS NP_014011.1 6323940 855328 838186..839994 1 NC_001145.2 Yku70p; Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair 839994 YKU70 855328 YKU70 Saccharomyces cerevisiae Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair NP_014011.1 838186 D 4932 CDS NP_014012.1 6323941 855329 complement(840143..841690) 1 NC_001145.2 Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p and Ngl3p; Ngl2p 841690 NGL2 855329 NGL2 Saccharomyces cerevisiae Ngl2p NP_014012.1 840143 R 4932 CDS NP_014013.1 6323942 855330 841941..842201 1 NC_001145.2 Mrpl33p; Mitochondrial ribosomal protein of the large subunit 842201 MRPL33 855330 MRPL33 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit NP_014013.1 841941 D 4932 CDS NP_014014.1 6323943 855331 complement(842435..845344) 1 NC_001145.2 Dss1p; 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs 845344 DSS1 855331 DSS1 Saccharomyces cerevisiae 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs NP_014014.1 842435 R 4932 CDS NP_014015.1 6323944 855332 845570..848485 1 NC_001145.2 U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155; Hsh155p 848485 HSH155 855332 HSH155 Saccharomyces cerevisiae Hsh155p NP_014015.1 845570 D 4932 CDS NP_014016.1 6323945 855333 848684..849808 1 NC_001145.2 Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis; Abz2p 849808 ABZ2 855333 ABZ2 Saccharomyces cerevisiae Abz2p NP_014016.1 848684 D 4932 CDS NP_014017.1 6323947 855335 complement(850073..851590) 1 NC_001145.2 Has1p; ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles 851590 HAS1 855335 HAS1 Saccharomyces cerevisiae ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles NP_014017.1 850073 R 4932 CDS NP_014019.1 6323948 855336 852629..854389 1 NC_001145.2 Ymr291wp; Putative kinase of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR291W is not an essential gene 854389 855336 YMR291W Saccharomyces cerevisiae Putative kinase of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR291W is not an essential gene NP_014019.1 852629 D 4932 CDS NP_014020.1 6323949 855337 join(854794..854815,854898..855292) 1 NC_001145.2 Got1p; Evolutionarily conserved non-essential protein present in early Golgi cisternae that may be involved in ER-Golgi transport at a step after vesicle tethering to Golgi membranes, exhibits membrane topology similar to that of Sft2p 855292 GOT1 855337 GOT1 Saccharomyces cerevisiae Evolutionarily conserved non-essential protein present in early Golgi cisternae that may be involved in ER-Golgi transport at a step after vesicle tethering to Golgi membranes, exhibits membrane topology similar to that of Sft2p NP_014020.1 854794 D 4932 CDS NP_014021.1 6323950 855338 complement(855398..856792) 1 NC_001145.2 Putative protein similar to bacterial glutamyl-tRNA amidotransferases; non-tagged protein is detected in purified mitochondria; null mutant displays decreased frequency of mitochondrial genome loss (petite formation); Lrc6p 856792 LRC6 855338 LRC6 Saccharomyces cerevisiae Lrc6p NP_014021.1 855398 R 4932 CDS NP_014022.1 6323951 855339 856965..858086 1 NC_001145.2 Jnm1p; Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B 858086 JNM1 855339 JNM1 Saccharomyces cerevisiae Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B NP_014022.1 856965 D 4932 CDS NP_014024.1 6323953 855341 complement(858296..858889) 1 NC_001145.2 Ymr295cp; Protein of unknown function that associates with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud; YMR295C is not an essential gene 858889 855341 YMR295C Saccharomyces cerevisiae Protein of unknown function that associates with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud; YMR295C is not an essential gene NP_014024.1 858296 R 4932 CDS NP_014025.1 6323954 855342 complement(859214..860890) 1 NC_001145.2 Lcb1p; Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine 860890 LCB1 855342 LCB1 Saccharomyces cerevisiae Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine NP_014025.1 859214 R 4932 CDS NP_014026.1 6323955 855343 861921..863519 1 NC_001145.2 Vacuolar carboxypeptidase Y (proteinase C), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family; Prc1p 863519 PRC1 855343 PRC1 Saccharomyces cerevisiae Prc1p NP_014026.1 861921 D 4932 CDS NP_014027.1 6323956 855344 863818..864270 1 NC_001145.2 Lip1p; Ceramide synthase subunit; single-span ER membrane protein associated with Lag1p and Lac1p and required for ceramide synthase activity, null mutant grows extremely slowly and is defective in ceramide synthesis 864270 LIP1 855344 LIP1 Saccharomyces cerevisiae Ceramide synthase subunit; single-span ER membrane protein associated with Lag1p and Lac1p and required for ceramide synthase activity, null mutant grows extremely slowly and is defective in ceramide synthesis NP_014027.1 863818 D 4932 CDS NP_014028.1 6323957 855345 complement(864411..865349) 1 NC_001145.2 Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration; Dyn3p 865349 DYN3 855345 DYN3 Saccharomyces cerevisiae Dyn3p NP_014028.1 864411 R 4932 CDS NP_014029.1 6323958 855346 complement(865558..867090) 1 NC_001145.2 Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway; Ade4p 867090 ADE4 855346 ADE4 Saccharomyces cerevisiae Ade4p NP_014029.1 865558 R 4932 CDS NP_014030.1 6323959 855347 complement(867554..869626) 1 NC_001145.2 Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol; Atm1p 869626 ATM1 855347 ATM1 Saccharomyces cerevisiae Atm1p NP_014030.1 867554 R 4932 CDS NP_014031.1 6323960 855348 complement(870072..872624) 1 NC_001145.2 Yme2p; Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases 872624 YME2 855348 YME2 Saccharomyces cerevisiae Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases NP_014031.1 870072 R 4932 CDS NP_014032.1 6323961 855349 complement(873290..874336) 1 NC_001145.2 Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1; Adh2p 874336 ADH2 855349 ADH2 Saccharomyces cerevisiae Adh2p NP_014032.1 873290 R 4932 CDS NP_014033.1 6323962 855350 874986..878678 1 NC_001145.2 Ubp15p; Ubiquitin-specific protease that may play a role in ubiquitin precursor processing 878678 UBP15 855350 UBP15 Saccharomyces cerevisiae Ubiquitin-specific protease that may play a role in ubiquitin precursor processing NP_014033.1 874986 D 4932 CDS NP_014035.1 6323964 855352 complement(879062..880231) 1 NC_001145.2 Scw10p; Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p 880231 SCW10 855352 SCW10 Saccharomyces cerevisiae Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p NP_014035.1 879062 R 4932 CDS NP_014036.1 6323965 855353 881158..886515 1 NC_001145.2 Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Fks3p 886515 FKS3 855353 FKS3 Saccharomyces cerevisiae Fks3p NP_014036.1 881158 D 4932 CDS NP_014038.1 6323967 855355 887002..888681 1 NC_001145.2 Gas1p; Beta-1,3-glucanosyltransferase, required for cell wall assembly; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor 888681 GAS1 855355 GAS1 Saccharomyces cerevisiae Beta-1,3-glucanosyltransferase, required for cell wall assembly; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor NP_014038.1 887002 D 4932 CDS NP_014039.1 6323968 855356 complement(888951..892220) 1 NC_001145.2 Pse1p; Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p 892220 PSE1 855356 PSE1 Saccharomyces cerevisiae Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p NP_014039.1 888951 R 4932 CDS NP_014040.1 6323969 855357 complement(892987..895425) 1 NC_001145.2 Subunit of the eukaryotic translation initiation factor 3 (eIF3), involved in the assembly of preinitiation complex and start codon selection; Nip1p 895425 NIP1 855357 NIP1 Saccharomyces cerevisiae Nip1p NP_014040.1 892987 R 4932 CDS NP_014041.1 6323970 855358 complement(895715..896668) 1 NC_001145.2 Ymr310cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR310C is not an essential gene 896668 855358 YMR310C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR310C is not an essential gene NP_014041.1 895715 R 4932 CDS NP_014042.1 6323971 855359 complement(896913..897602) 1 NC_001145.2 Regulatory subunit of protein phosphatase 1 (Glc7p), involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2; Glc8p 897602 GLC8 855359 GLC8 Saccharomyces cerevisiae Glc8p NP_014042.1 896913 R 4932 CDS NP_014043.1 6323972 855360 898404..899225 1 NC_001145.2 Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity; Elp6p 899225 ELP6 855360 ELP6 Saccharomyces cerevisiae Elp6p NP_014043.1 898404 D 4932 CDS NP_014044.1 6323973 855361 complement(899378..901306) 1 NC_001145.2 Triacylglycerol lipase of the lipid particle, responsible for all the TAG lipase activity of the lipid particle; contains the consensus sequence motif GXSXG, which is found in lipolytic enzymes; Tgl3p 901306 TGL3 855361 TGL3 Saccharomyces cerevisiae Tgl3p NP_014044.1 899378 R 4932 CDS NP_014045.1 6323974 855362 901708..902412 1 NC_001145.2 Pre5p; 20S proteasome alpha-type subunit 902412 PRE5 855362 PRE5 Saccharomyces cerevisiae 20S proteasome alpha-type subunit NP_014045.1 901708 D 4932 CDS NP_014046.1 6323975 855363 902799..903848 1 NC_001145.2 Ymr315wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR315W is not an essential gene 903848 855363 YMR315W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR315W is not an essential gene NP_014046.1 902799 D 4932 CDS NP_878150.1 33438862 1466508 904285..904392 1 NC_001145.2 Ymr315w-ap; Putative protein of unknown function 904392 1466508 YMR315W-A Saccharomyces cerevisiae Putative protein of unknown function NP_878150.1 904285 D 4932 CDS NP_014047.1 6323976 855364 904823..905833 1 NC_001145.2 Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; Dia1p 905833 DIA1 855364 DIA1 Saccharomyces cerevisiae Dia1p NP_014047.1 904823 D 4932 CDS NP_014050.1 6323978 855366 907362..910784 1 NC_001145.2 Ymr317wp; Putative protein of unknown function with some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene 910784 855366 YMR317W Saccharomyces cerevisiae Putative protein of unknown function with some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene NP_014050.1 907362 D 4932 CDS NP_014051.1 6323980 855368 complement(911059..912141) 1 NC_001145.2 NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance; Adh6p 912141 ADH6 855368 ADH6 Saccharomyces cerevisiae Adh6p NP_014051.1 911059 R 4932 CDS NP_014052.1 6323981 855369 complement(912878..914536) 1 NC_001145.2 Low-affinity Fe(II) transporter of the plasma membrane; Fet4p 914536 FET4 855369 FET4 Saccharomyces cerevisiae Fet4p NP_014052.1 912878 R 4932 CDS NP_014054.1 6323983 855371 complement(917577..917894) 1 NC_001145.2 Ymr321cp; Putative protein of unknown function 917894 855371 YMR321C Saccharomyces cerevisiae Putative protein of unknown function NP_014054.1 917577 R 4932 CDS NP_014055.1 6323984 855372 complement(918364..919077) 1 NC_001145.2 Sno4p; Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Hsp33p; member of the DJ-1/ThiJ/PfpI superfamily; may have a role in pyridoxine metabolism 919077 SNO4 855372 SNO4 Saccharomyces cerevisiae Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Hsp33p; member of the DJ-1/ThiJ/PfpI superfamily; may have a role in pyridoxine metabolism NP_014055.1 918364 R 4932 CDS NP_014056.1 6323985 855373 920086..921399 1 NC_001145.2 Protein of unknown function, has similarity to enolases; Err3p 921399 ERR3 855373 ERR3 Saccharomyces cerevisiae Err3p NP_014056.1 920086 D 4932 CDS NP_014058.1 6323987 855375 922639..923013 1 NC_001145.2 Pau19p 923013 PAU19 855375 PAU19 Saccharomyces cerevisiae Pau19p NP_014058.1 922639 D 4932 CDS NP_014060.1 6323990 855377 complement(join(371..5931,6080..6098)) 1 NC_001146.6 Yrf1-6p; Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p 6098 YRF1-6 855377 YRF1-6 Saccharomyces cerevisiae Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p NP_014060.1 371 R 4932 CDS NP_014063.1 6323993 855380 8330..9475 1 NC_001146.6 Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; Cos1p 9475 COS1 855380 COS1 Saccharomyces cerevisiae Cos1p NP_014063.1 8330 D 4932 CDS NP_014064.1 6323994 855381 11452..12129 1 NC_001146.6 Ddi3p 12129 DDI3 855381 DDI3 Saccharomyces cerevisiae Ddi3p NP_014064.1 11452 D 4932 CDS NP_014065.1 6323995 855382 complement(12208..12876) 1 NC_001146.6 Sno2p; Protein of unknown function, nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin 12876 SNO2 855382 SNO2 Saccharomyces cerevisiae Protein of unknown function, nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin NP_014065.1 12208 R 4932 CDS NP_014066.1 6323996 855383 13267..14163 1 NC_001146.6 Snz2p; Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p 14163 SNZ2 855383 SNZ2 Saccharomyces cerevisiae Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p NP_014066.1 13267 D 4932 CDS NP_014067.1 6323997 855384 14832..15854 1 NC_001146.6 Thi12p; Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13 15854 THI12 855384 THI12 Saccharomyces cerevisiae Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13 NP_014067.1 14832 D 4932 CDS NP_014068.1 6323998 855385 complement(16118..17248) 1 NC_001146.6 Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; Aad14p 17248 AAD14 855385 AAD14 Saccharomyces cerevisiae Aad14p NP_014068.1 16118 R 4932 CDS NP_014069.1 6323999 855386 complement(18001..19302) 1 NC_001146.6 Rpd3p; Histone deacetylase; regulates transcription and silencing 19302 RPD3 855386 RPD3 Saccharomyces cerevisiae Histone deacetylase; regulates transcription and silencing NP_014069.1 18001 R 4932 CDS NP_014070.1 6324000 855387 complement(19541..22633) 1 NC_001146.6 Pex6p; AAA-peroxin that heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol 22633 PEX6 855387 PEX6 Saccharomyces cerevisiae AAA-peroxin that heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol NP_014070.1 19541 R 4932 CDS NP_014071.1 6324001 855388 complement(22834..23274) 1 NC_001146.6 Mdj2p; Constituent of the mitochondrial import motor associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain 23274 MDJ2 855388 MDJ2 Saccharomyces cerevisiae Constituent of the mitochondrial import motor associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain NP_014071.1 22834 R 4932 CDS NP_014072.1 6324002 855389 24047..27172 1 NC_001146.6 Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner; Egt2p 27172 EGT2 855389 EGT2 Saccharomyces cerevisiae Egt2p NP_014072.1 24047 D 4932 CDS NP_014073.1 6324003 855390 complement(27336..28346) 1 NC_001146.6 Pfa3p; Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions 28346 PFA3 855390 PFA3 Saccharomyces cerevisiae Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions NP_014073.1 27336 R 4932 CDS NP_014074.1 6324005 855392 complement(28738..31377) 1 NC_001146.6 Polyphosphatidylinositol phosphatase involved in the metabolism of phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2); required for efficient mating; physically associates with and regulated by Vac14p; contains a SAC1-like domain; Fig4p 31377 FIG4 855392 FIG4 Saccharomyces cerevisiae Fig4p NP_014074.1 28738 R 4932 CDS NP_014076.1 6324006 855393 31943..33187 1 NC_001146.6 Membrane protein of the plasma membrane and ER, involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane; Lem3p 33187 LEM3 855393 LEM3 Saccharomyces cerevisiae Lem3p NP_014076.1 31943 D 4932 CDS NP_014077.1 6324007 855394 complement(33293..34234) 1 NC_001146.6 Kre1p; Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor 34234 KRE1 855394 KRE1 Saccharomyces cerevisiae Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor NP_014077.1 33293 R 4932 CDS NP_014078.1 6324008 855395 34695..37421 1 NC_001146.6 Vnx1p; Low affinity vacuolar membrane localized monovalent cation/H+ antiporter; member of the calcium exchanger (CAX) family; potential Cdc28p substrate 37421 VNX1 855395 VNX1 Saccharomyces cerevisiae Low affinity vacuolar membrane localized monovalent cation/H+ antiporter; member of the calcium exchanger (CAX) family; potential Cdc28p substrate NP_014078.1 34695 D 4932 CDS NP_014079.1 6324009 855396 37699..38553 1 NC_001146.6 Ynl320wp; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 38553 855396 YNL320W Saccharomyces cerevisiae Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_014079.1 37699 D 4932 CDS NP_014081.1 6324011 855398 complement(38706..40328) 1 NC_001146.6 Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Hxt14p 40328 HXT14 855398 HXT14 Saccharomyces cerevisiae Hxt14p NP_014081.1 38706 R 4932 CDS NP_014082.1 6324012 855399 40618..42015 1 NC_001146.6 Pfs2p; Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex; plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex 42015 PFS2 855399 PFS2 Saccharomyces cerevisiae Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex; plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex NP_014082.1 40618 D 4932 CDS NP_014083.2 37362685 855400 complement(42070..43074) 1 NC_001146.6 Prephenate dehydratase, catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway; Pha2p 43074 PHA2 855400 PHA2 Saccharomyces cerevisiae Pha2p NP_014083.2 42070 R 4932 CDS NP_014084.1 6324014 855401 complement(43323..44279) 1 NC_001146.6 Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; Atp11p 44279 ATP11 855401 ATP11 Saccharomyces cerevisiae Atp11p NP_014084.1 43323 R 4932 CDS NP_014085.1 6324015 855402 44446..45213 1 NC_001146.6 Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain; Dal82p 45213 DAL82 855402 DAL82 Saccharomyces cerevisiae Dal82p NP_014085.1 44446 D 4932 CDS NP_014086.1 6324016 855403 complement(45307..48021) 1 NC_001146.6 Ynl313cp; Putative protein of unknown function; identified as interacting with Kar2p, Grs1p, and Tub3p in high-throughput TAP-tagging experiments; YNL313C is an essential gene 48021 855403 YNL313C Saccharomyces cerevisiae Putative protein of unknown function; identified as interacting with Kar2p, Grs1p, and Tub3p in high-throughput TAP-tagging experiments; YNL313C is an essential gene NP_014086.1 45307 R 4932 CDS NP_014087.1 6324017 855404 join(48286..48292,48401..49215) 1 NC_001146.6 Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; Rfa2p 49215 RFA2 855404 RFA2 Saccharomyces cerevisiae Rfa2p NP_014087.1 48286 D 4932 CDS NP_014088.1 6324018 855405 complement(49396..51687) 1 NC_001146.6 Skp2p; Protein of unknown function that may interact with ribosomes, based on co-purification experiments; putative F-box protein; analysis of integrated high-throughput datasets predicts involvement in ubiquitin-dependent protein catabolism 51687 SKP2 855405 SKP2 Saccharomyces cerevisiae Protein of unknown function that may interact with ribosomes, based on co-purification experiments; putative F-box protein; analysis of integrated high-throughput datasets predicts involvement in ubiquitin-dependent protein catabolism NP_014088.1 49396 R 4932 CDS NP_014089.2 99030930 855406 complement(51906..52430) 1 NC_001146.6 Zim17p; Heat shock protein with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix 52430 ZIM17 855406 ZIM17 Saccharomyces cerevisiae Heat shock protein with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix NP_014089.2 51906 R 4932 CDS NP_014090.2 37362686 855407 52661..53923 1 NC_001146.6 Stb1p; Protein with a role in regulation of MBF-specific transcription at Start, phosphorylated by Cln-Cdc28p kinases in vitro; unphosphorylated form binds Swi6p and binding is required for Stb1p function; expression is cell-cycle regulated 53923 STB1 855407 STB1 Saccharomyces cerevisiae Protein with a role in regulation of MBF-specific transcription at Start, phosphorylated by Cln-Cdc28p kinases in vitro; unphosphorylated form binds Swi6p and binding is required for Stb1p function; expression is cell-cycle regulated NP_014090.2 52661 D 4932 CDS NP_014091.1 6324021 855408 complement(54121..55896) 1 NC_001146.6 Kri1p; Essential nucleolar protein required for 40S ribosome biogenesis; physically and functionally interacts with Krr1p 55896 KRI1 855408 KRI1 Saccharomyces cerevisiae Essential nucleolar protein required for 40S ribosome biogenesis; physically and functionally interacts with Krr1p NP_014091.1 54121 R 4932 CDS NP_014092.1 6324022 855409 complement(56446..57573) 1 NC_001146.6 Protein serine/threonine/tyrosine (dual-specificity) kinase involved in control of chromosome segregation and in regulating entry into meiosis; related to mammalian glycogen synthase kinases of the GSK-3 family; Mck1p 57573 MCK1 855409 MCK1 Saccharomyces cerevisiae Mck1p NP_014092.1 56446 R 4932 CDS NP_014093.1 6324023 855410 58155..58808 1 NC_001146.6 Mrps18p; Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins 58808 MRPS18 855410 MRPS18 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins NP_014093.1 58155 D 4932 CDS NP_014094.1 6324024 855411 complement(58898..59791) 1 NC_001146.6 Ynl305cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL305C is not an essential gene 59791 855411 YNL305C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL305C is not an essential gene NP_014094.1 58898 R 4932 CDS NP_014095.2 82795261 855412 60297..61550 1 NC_001146.6 Ypt11p; Rab-type small GTPase that interacts with the C-terminal tail domain of Myo2p to mediate distribution of mitochondria to daughter cells 61550 YPT11 855412 YPT11 Saccharomyces cerevisiae Rab-type small GTPase that interacts with the C-terminal tail domain of Myo2p to mediate distribution of mitochondria to daughter cells NP_014095.2 60297 D 4932 CDS NP_014097.1 6324027 855414 complement(join(61958..62372,62924..62943)) 1 NC_001146.6 Rps19bp; Protein component of the small (40S) ribosomal subunit, required for assembly and maturation of pre-40 S particles; mutations in human RPS19 are associated with Diamond Blackfan anemia; nearly identical to Rps19Ap 62943 RPS19B 855414 RPS19B Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit, required for assembly and maturation of pre-40 S particles; mutations in human RPS19 are associated with Diamond Blackfan anemia; nearly identical to Rps19Ap NP_014097.1 61958 R 4932 CDS NP_014098.1 6324028 855415 complement(join(63570..64018,64451..64562)) 1 NC_001146.6 Rpl18bp; Protein component of the large (60S) ribosomal subunit, identical to Rpl18Ap and has similarity to rat L18 ribosomal protein 64562 RPL18B 855415 RPL18B Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, identical to Rpl18Ap and has similarity to rat L18 ribosomal protein NP_014098.1 63570 R 4932 CDS NP_014099.1 6324029 855416 65744..66052 1 NC_001146.6 Ynl300wp; Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid 66052 855416 YNL300W Saccharomyces cerevisiae Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid NP_014099.1 65744 D 4932 CDS NP_014100.2 81360384 855417 66517..68445 1 NC_001146.6 Trf5p; Poly (A) polymerase involved in nuclear RNA quality control based on: homology with Trf4p, genetic interactions with TRF4 mutants, physical interaction with Mtr4p (TRAMP subunit), and by direct assay; disputed role as a sigma DNA polymerase 68445 TRF5 855417 TRF5 Saccharomyces cerevisiae Poly (A) polymerase involved in nuclear RNA quality control based on: homology with Trf4p, genetic interactions with TRF4 mutants, physical interaction with Mtr4p (TRAMP subunit), and by direct assay; disputed role as a sigma DNA polymerase NP_014100.2 66517 D 4932 CDS NP_014101.1 6324031 855418 68915..71443 1 NC_001146.6 Cla4p; Cdc42p activated signal transducing kinase of the PAK (p21-activated kinase) family, involved in septin ring assembly and cytokinesis; directly phosphorylates septins Cdc3p and Cdc10p; other yeast PAK family members are Ste20p and Skm1p 71443 CLA4 855418 CLA4 Saccharomyces cerevisiae Cdc42p activated signal transducing kinase of the PAK (p21-activated kinase) family, involved in septin ring assembly and cytokinesis; directly phosphorylates septins Cdc3p and Cdc10p; other yeast PAK family members are Ste20p and Skm1p NP_014101.1 68915 D 4932 CDS NP_014102.1 6324033 855420 complement(71673..76583) 1 NC_001146.6 Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins; Mon2p 76583 MON2 855420 MON2 Saccharomyces cerevisiae Mon2p NP_014102.1 71673 R 4932 CDS NP_014104.1 6324034 855421 76946..78520 1 NC_001146.6 Ynl295wp; Putative protein of unknown function 78520 855421 YNL295W Saccharomyces cerevisiae Putative protein of unknown function NP_014104.1 76946 D 4932 CDS NP_014105.1 6324035 855422 complement(78659..80260) 1 NC_001146.6 Rim21p; Component of the RIM101 pathway, has a role in cell wall construction and alkaline pH response; has similarity to A. nidulans PalH 80260 RIM21 855422 RIM21 Saccharomyces cerevisiae Component of the RIM101 pathway, has a role in cell wall construction and alkaline pH response; has similarity to A. nidulans PalH NP_014105.1 78659 R 4932 CDS NP_014106.1 6324036 855423 80640..82541 1 NC_001146.6 Msb3p; GTPase-activating protein for Sec4p and several other Rab GTPases, regulates exocytosis via its action on Sec4p, also required for proper actin organization; similar to Msb4p; both Msb3p and Msb4p localize to sites of polarized growth 82541 MSB3 855423 MSB3 Saccharomyces cerevisiae GTPase-activating protein for Sec4p and several other Rab GTPases, regulates exocytosis via its action on Sec4p, also required for proper actin organization; similar to Msb4p; both Msb3p and Msb4p localize to sites of polarized growth NP_014106.1 80640 D 4932 CDS NP_014107.1 6324037 855424 82806..84017 1 NC_001146.6 Pus4p; Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype) 84017 PUS4 855424 PUS4 Saccharomyces cerevisiae Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype) NP_014107.1 82806 D 4932 CDS NP_014108.1 6324038 855425 complement(84169..85815) 1 NC_001146.6 N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer; Mid1p 85815 MID1 855425 MID1 Saccharomyces cerevisiae Mid1p NP_014108.1 84169 R 4932 CDS NP_014109.1 6324039 855426 86218..87240 1 NC_001146.6 Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; Rfc3p 87240 RFC3 855426 RFC3 Saccharomyces cerevisiae Rfc3p NP_014109.1 86218 D 4932 CDS NP_014110.1 6324040 855427 87897..88736 1 NC_001146.6 Pho85 cyclin of the Pcl1,2-like subfamily, involved in entry into the mitotic cell cycle and regulation of morphogenesis, localizes to sites of polarized cell growth; Pcl1p 88736 PCL1 855427 PCL1 Saccharomyces cerevisiae Pcl1p NP_014110.1 87897 D 4932 CDS NP_014111.1 6324041 855428 90303..91424 1 NC_001146.6 Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p; Caf40p 91424 CAF40 855428 CAF40 Saccharomyces cerevisiae Caf40p NP_014111.1 90303 D 4932 CDS NP_014112.1 6324042 855429 91994..94801 1 NC_001146.6 Sec21p; Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo 94801 SEC21 855429 SEC21 Saccharomyces cerevisiae Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo NP_014112.1 91994 D 4932 CDS NP_014113.1 6324043 855430 95223..96080 1 NC_001146.6 Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs); Cus2p 96080 CUS2 855430 CUS2 Saccharomyces cerevisiae Cus2p NP_014113.1 95223 D 4932 CDS NP_058178.1 7839194 855433 complement(join(96964..100926,100928..102232)) 1 NC_001146.6 Ynl284c-bp; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 102232 855433 YNL284C-B Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_058178.1 96964 R 4932 CDS NP_058179.1 7839193 855434 complement(100910..102232) 1 NC_001146.6 Ynl284c-ap; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 102232 855434 YNL284C-A Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_058179.1 100910 R 4932 CDS NP_014115.1 6324045 855436 complement(103134..104102) 1 NC_001146.6 Mrpl10p; Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels 104102 MRPL10 855436 MRPL10 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels NP_014115.1 103134 R 4932 CDS NP_014116.1 6324046 855438 complement(105184..106695) 1 NC_001146.6 Wsc2p; Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response 106695 WSC2 855438 WSC2 Saccharomyces cerevisiae Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response NP_014116.1 105184 R 4932 CDS NP_014117.1 6324047 855439 107687..108274 1 NC_001146.6 Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; Pop3p 108274 POP3 855439 POP3 Saccharomyces cerevisiae Pop3p NP_014117.1 107687 D 4932 CDS NP_014118.1 6324048 855440 108467..108928 1 NC_001146.6 Heat shock protein regulator that binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; GFP-fusion protein localizes to the cytoplasm and nucleus; Hch1p 108928 HCH1 855440 HCH1 Saccharomyces cerevisiae Hch1p NP_014118.1 108467 D 4932 CDS NP_014119.1 6324049 855441 complement(109095..110411) 1 NC_001146.6 Erg24p; C-14 sterol reductase, acts in ergosterol biosynthesis; mutants accumulate the abnormal sterol ignosterol (ergosta-8,14 dienol), and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions 110411 ERG24 855441 ERG24 Saccharomyces cerevisiae C-14 sterol reductase, acts in ergosterol biosynthesis; mutants accumulate the abnormal sterol ignosterol (ergosta-8,14 dienol), and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions NP_014119.1 109095 R 4932 CDS NP_014120.1 6324050 855442 110917..112902 1 NC_001146.6 Prm1p; Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p 112902 PRM1 855442 PRM1 Saccharomyces cerevisiae Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p NP_014120.1 110917 D 4932 CDS NP_014121.1 6324051 855443 113271..116453 1 NC_001146.6 Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation; Caf120p 116453 CAF120 855443 CAF120 Saccharomyces cerevisiae Caf120p NP_014121.1 113271 D 4932 CDS NP_878151.1 33438863 1466509 116679..116867 1 NC_001146.6 Ynl277w-ap; Putative protein of unknown function 116867 1466509 YNL277W-A Saccharomyces cerevisiae Putative protein of unknown function NP_878151.1 116679 D 4932 CDS NP_014122.1 6324052 855444 117349..118809 1 NC_001146.6 Met2p; L-homoserine-O-acetyltransferase, catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway 118809 MET2 855444 MET2 Saccharomyces cerevisiae L-homoserine-O-acetyltransferase, catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway NP_014122.1 117349 D 4932 CDS NP_014124.1 6324054 855446 119268..120998 1 NC_001146.6 Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1; Bor1p 120998 BOR1 855446 BOR1 Saccharomyces cerevisiae Bor1p NP_014124.1 119268 D 4932 CDS NP_014125.1 6324055 855447 complement(121118..122170) 1 NC_001146.6 Gor1p; Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 122170 GOR1 855447 GOR1 Saccharomyces cerevisiae Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_014125.1 121118 R 4932 CDS NP_014126.1 6324056 855448 122883..126599 1 NC_001146.6 Tof1p; Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase 126599 TOF1 855448 TOF1 Saccharomyces cerevisiae Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase NP_014126.1 122883 D 4932 CDS NP_014127.1 6324057 855449 complement(126805..129084) 1 NC_001146.6 Sec2p; Guanyl-nucleotide exchange factor for the small G-protein Sec4p, located on cytoplasmic vesicles; essential for post-Golgi vesicle transport 129084 SEC2 855449 SEC2 Saccharomyces cerevisiae Guanyl-nucleotide exchange factor for the small G-protein Sec4p, located on cytoplasmic vesicles; essential for post-Golgi vesicle transport NP_014127.1 126805 R 4932 CDS NP_014128.1 6324058 855450 complement(129523..135384) 1 NC_001146.6 Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1; Bni1p 135384 BNI1 855450 BNI1 Saccharomyces cerevisiae Bni1p NP_014128.1 129523 R 4932 CDS NP_014129.1 6324059 855451 complement(135941..137662) 1 NC_001146.6 Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression; Alp1p 137662 ALP1 855451 ALP1 Saccharomyces cerevisiae Alp1p NP_014129.1 135941 R 4932 CDS NP_014130.1 6324060 855452 137700..138095 1 NC_001146.6 Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p; Bsc4p 138095 BSC4 855452 BSC4 Saccharomyces cerevisiae Bsc4p NP_014130.1 137700 D 4932 CDS NP_014131.1 6324061 855453 138551..140386 1 NC_001146.6 Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids; Lyp1p 140386 LYP1 855453 LYP1 Saccharomyces cerevisiae Lyp1p NP_014131.1 138551 D 4932 CDS NP_014132.1 6324062 855454 140879..144079 1 NC_001146.6 Pik1p; Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokineses through the actin cytoskeleton 144079 PIK1 855454 PIK1 Saccharomyces cerevisiae Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokineses through the actin cytoskeleton NP_014132.1 140879 D 4932 CDS NP_014134.1 6324064 855456 complement(join(144281..145150,145256..145282)) 1 NC_001146.6 Putative translation initiation factor, as suggested by computational analysis of large-scale protein-protein interaction data; Ist1p 145282 IST1 855456 IST1 Saccharomyces cerevisiae Ist1p NP_014134.1 144281 R 4932 CDS NP_014135.1 6324065 855457 complement(145564..146616) 1 NC_001146.6 Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition; Pdr17p 146616 PDR17 855457 PDR17 Saccharomyces cerevisiae Pdr17p NP_014135.1 145564 R 4932 CDS NP_014136.1 6324066 855458 complement(146897..147841) 1 NC_001146.6 Yif1p; Integral membrane protein required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles 147841 YIF1 855458 YIF1 Saccharomyces cerevisiae Integral membrane protein required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles NP_014136.1 146897 R 4932 CDS NP_014137.1 6324067 855459 148213..154881 1 NC_001146.6 Pol2p; Catalytic subunit of DNA polymerase (II) epsilon, one of the major chromosomal DNA replication polymerases characterized by processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair 154881 POL2 855459 POL2 Saccharomyces cerevisiae Catalytic subunit of DNA polymerase (II) epsilon, one of the major chromosomal DNA replication polymerases characterized by processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair NP_014137.1 148213 D 4932 CDS NP_014138.1 6324068 855460 155101..156540 1 NC_001146.6 Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; Orc5p 156540 ORC5 855460 ORC5 Saccharomyces cerevisiae Orc5p NP_014138.1 155101 D 4932 CDS NP_014139.1 6324069 855461 complement(156860..157456) 1 NC_001146.6 Ynl260cp; Putative protein of unknown function with similarity to a human protein overexpressed in oral cancers; localizes to the nucleus and cytoplasm; YNL260C is an essential gene 157456 855461 YNL260C Saccharomyces cerevisiae Putative protein of unknown function with similarity to a human protein overexpressed in oral cancers; localizes to the nucleus and cytoplasm; YNL260C is an essential gene NP_014139.1 156860 R 4932 CDS NP_014140.1 6324070 855462 complement(157645..157866) 1 NC_001146.6 Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake; Atx1p 157866 ATX1 855462 ATX1 Saccharomyces cerevisiae Atx1p NP_014140.1 157645 R 4932 CDS NP_014141.1 6324071 855463 complement(158110..160374) 1 NC_001146.6 Peripheral membrane protein required for Golgi-to-ER retrograde traffic; component of the ER target site that interacts with coatomer, the major component of the COPI vesicle protein coat; also interacts with Cin5p and Sec39p; Dsl1p 160374 DSL1 855463 DSL1 Saccharomyces cerevisiae Dsl1p NP_014141.1 158110 R 4932 CDS NP_014142.1 6324072 855464 complement(160632..164321) 1 NC_001146.6 Sip3p; Protein that activates transcription through interaction with DNA-bound Snf1p, C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate 164321 SIP3 855464 SIP3 Saccharomyces cerevisiae Protein that activates transcription through interaction with DNA-bound Snf1p, C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate NP_014142.1 160632 R 4932 CDS NP_014143.2 37362687 855465 164624..167098 1 NC_001146.6 Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities; Fol1p 167098 FOL1 855465 FOL1 Saccharomyces cerevisiae Fol1p NP_014143.2 164624 D 4932 CDS NP_014144.1 6324074 855466 complement(167330..167791) 1 NC_001146.6 Protein with seven cysteine-rich CCHC zinc-finger motifs, similar to human CNBP, proposed to be involved in the RAS/cAMP signaling pathway; Gis2p 167791 GIS2 855466 GIS2 Saccharomyces cerevisiae Gis2p NP_014144.1 167330 R 4932 CDS NP_014145.1 6324075 855467 complement(168044..169249) 1 NC_001146.6 Ynl254cp 169249 855467 YNL254C Saccharomyces cerevisiae Ynl254cp NP_014145.1 168044 R 4932 CDS NP_014146.1 6324076 855468 170019..171287 1 NC_001146.6 Tex1p; Protein involved in mRNA export, component of the transcription export (TREX) complex 171287 TEX1 855468 TEX1 Saccharomyces cerevisiae Protein involved in mRNA export, component of the transcription export (TREX) complex NP_014146.1 170019 D 4932 CDS NP_014147.1 6324077 855469 complement(171442..172287) 1 NC_001146.6 Mrpl17p; Mitochondrial ribosomal protein of the large subunit 172287 MRPL17 855469 MRPL17 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit NP_014147.1 171442 R 4932 CDS NP_014148.1 6324078 855470 complement(172589..174316) 1 NC_001146.6 RNA-binding protein that interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p), required for transcription termination and 3' end maturation of nonpolyadenylated RNAs; Nrd1p 174316 NRD1 855470 NRD1 Saccharomyces cerevisiae Nrd1p NP_014148.1 172589 R 4932 CDS NP_014149.1 6324079 855471 175411..179349 1 NC_001146.6 Subunit of MRX complex, with Mre11p and Xrs2p, involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining; Rad50p 179349 RAD50 855471 RAD50 Saccharomyces cerevisiae Rad50p NP_014149.1 175411 D 4932 CDS NP_014150.1 6324080 855472 complement(179395..181023) 1 NC_001146.6 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Mpa43p 181023 MPA43 855472 MPA43 Saccharomyces cerevisiae Mpa43p NP_014150.1 179395 R 4932 CDS NP_014151.1 6324081 855473 complement(181362..182609) 1 NC_001146.6 Rpa49p; RNA polymerase I subunit A49 182609 RPA49 855473 RPA49 Saccharomyces cerevisiae RNA polymerase I subunit A49 NP_014151.1 181362 R 4932 CDS NP_014152.1 6324082 855474 182876..185179 1 NC_001146.6 Ynl247wp; Essential protein of unknown function; may interact with ribosomes, based on co-purification experiments 185179 855474 YNL247W Saccharomyces cerevisiae Essential protein of unknown function; may interact with ribosomes, based on co-purification experiments NP_014152.1 182876 D 4932 CDS NP_014153.1 6324083 855475 join(185461..185492,185588..186350) 1 NC_001146.6 Vps75p; NAP family histone chaperone; binds to histone H3-H4 tetramers and to histone acetyltransferase RTT109; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting 186350 VPS75 855475 VPS75 Saccharomyces cerevisiae NAP family histone chaperone; binds to histone H3-H4 tetramers and to histone acetyltransferase RTT109; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting NP_014153.1 185461 D 4932 CDS NP_014154.1 6324084 855476 complement(186347..186886) 1 NC_001146.6 Cwc25p; Component of a complex containing Cef1p, involved in pre-mRNA splicing; has similarity to S. pombe Cwf25p 186886 CWC25 855476 CWC25 Saccharomyces cerevisiae Component of a complex containing Cef1p, involved in pre-mRNA splicing; has similarity to S. pombe Cwf25p NP_014154.1 186347 R 4932 CDS NP_014155.1 6324085 855477 complement(187171..187497) 1 NC_001146.6 Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase; Sui1p 187497 SUI1 855477 SUI1 Saccharomyces cerevisiae Sui1p NP_014155.1 187171 R 4932 CDS NP_014156.1 6324086 855478 188052..190958 1 NC_001146.6 Transmembrane actin-binding protein involved in membrane cytoskeleton assembly and cell polarization; adaptor protein that links actin to clathrin and endocytosis; present in the actin cortical patch of the emerging bud tip; dimer in vivo; Sla2p 190958 SLA2 855478 SLA2 Saccharomyces cerevisiae Sla2p NP_014156.1 188052 D 4932 CDS NP_014157.1 6324087 855479 191325..196103 1 NC_001146.6 Peripheral membrane protein required for the formation of cytosolic sequestering vesicles involved in vacuolar import through both the Cvt pathway and autophagy; interacts with Atg9p and is necessary for its trafficking; Atg2p 196103 ATG2 855479 ATG2 Saccharomyces cerevisiae Atg2p NP_014157.1 191325 D 4932 CDS NP_014158.1 6324088 855480 complement(196427..197944) 1 NC_001146.6 Zwf1p; Glucose-6-phosphate dehydrogenase (G6PD), catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia 197944 ZWF1 855480 ZWF1 Saccharomyces cerevisiae Glucose-6-phosphate dehydrogenase (G6PD), catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia NP_014158.1 196427 R 4932 CDS NP_014159.1 6324089 855481 complement(198503..199978) 1 NC_001146.6 Nuclear architecture related protein; component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins; homologous to human Narf; Nar1p 199978 NAR1 855481 NAR1 Saccharomyces cerevisiae Nar1p NP_014159.1 198503 R 4932 CDS NP_014160.2 27808714 855482 200570..201934 1 NC_001146.6 Lap3p; Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH 201934 LAP3 855482 LAP3 Saccharomyces cerevisiae Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH NP_014160.2 200570 D 4932 CDS NP_014161.1 6324091 855483 202429..204873 1 NC_001146.6 Subtilisin-like protease (proprotein convertase), a calcium-dependent serine protease involved in the activation of proproteins of the secretory pathway; Kex2p 204873 KEX2 855483 KEX2 Saccharomyces cerevisiae Kex2p NP_014161.1 202429 D 4932 CDS NP_014162.1 6324092 855484 205189..206568 1 NC_001146.6 Ytp1p; Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins 206568 YTP1 855484 YTP1 Saccharomyces cerevisiae Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins NP_014162.1 205189 D 4932 CDS NP_014163.1 6324093 855485 206931..209855 1 NC_001146.6 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription; Sin4p 209855 SIN4 855485 SIN4 Saccharomyces cerevisiae Sin4p NP_014163.1 206931 D 4932 CDS NP_014165.1 6324095 855487 210234..211514 1 NC_001146.6 Ynl234wp; Similar to globins and has a functional heme-binding domain; involved in glucose signaling or metabolism; regulated by Rgt1p 211514 855487 YNL234W Saccharomyces cerevisiae Similar to globins and has a functional heme-binding domain; involved in glucose signaling or metabolism; regulated by Rgt1p NP_014165.1 210234 D 4932 CDS NP_014166.1 6324096 855488 211923..214601 1 NC_001146.6 Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p; Bni4p 214601 BNI4 855488 BNI4 Saccharomyces cerevisiae Bni4p NP_014166.1 211923 D 4932 CDS NP_014167.1 6324097 855489 214924..215802 1 NC_001146.6 Subunit of the exosome, which is an essential complex present in both nucleus and cytoplasm that mediates RNA processing and degradation; Csl4p 215802 CSL4 855489 CSL4 Saccharomyces cerevisiae Csl4p NP_014167.1 214924 D 4932 CDS NP_014168.1 6324098 855490 complement(215988..217043) 1 NC_001146.6 Phosphatidylinositol transfer protein (PITP) controlled by the multiple drug resistance regulator Pdr1p, localizes to lipid particles and microsomes, controls levels of various lipids, may regulate lipid synthesis, homologous to Pdr17p; Pdr16p 217043 PDR16 855490 PDR16 Saccharomyces cerevisiae Pdr16p NP_014168.1 215988 R 4932 CDS NP_014169.1 6324099 855491 complement(217524..218663) 1 NC_001146.6 Elongin A, F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degredation of the RNA Polymerase II subunit RPO21; subunit of the Elongin-Cullin-Socs (ECS) ligase complex; Ela1p 218663 ELA1 855491 ELA1 Saccharomyces cerevisiae Ela1p NP_014169.1 217524 R 4932 CDS NP_014170.1 6324100 855492 complement(219138..220202) 1 NC_001146.6 Ure2p; Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; altered form of Ure2p creates [URE3] prion 220202 URE2 855492 URE2 Saccharomyces cerevisiae Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; altered form of Ure2p creates [URE3] prion NP_014170.1 219138 R 4932 CDS NP_014172.1 6324103 855495 complement(220660..222432) 1 NC_001146.6 Jjj1p; Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis 222432 JJJ1 855495 JJJ1 Saccharomyces cerevisiae Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis NP_014172.1 220660 R 4932 CDS NP_014174.1 6324104 855496 complement(222725..224470) 1 NC_001146.6 Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration; Cnm67p 224470 CNM67 855496 CNM67 Saccharomyces cerevisiae Cnm67p NP_014174.1 222725 R 4932 CDS NP_014175.1 6324105 855497 complement(224797..227100) 1 NC_001146.6 Sqs1p; Protein of unknown function; overexpression antagonizes the suppression of splicing defects by spp382 mutants; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus 227100 SQS1 855497 SQS1 Saccharomyces cerevisiae Protein of unknown function; overexpression antagonizes the suppression of splicing defects by spp382 mutants; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus NP_014175.1 224797 R 4932 CDS NP_014176.2 37362688 855498 227371..228855 1 NC_001146.6 Cysteine protease required for autophagy; cleaves Atg8p to a form required for autophagosome and Cvt vesicle generation; mediates attachment of autophagosomes to microtubules through interactions with Tub1p and Tub2p; Atg4p 228855 ATG4 855498 ATG4 Saccharomyces cerevisiae Atg4p NP_014176.2 227371 D 4932 CDS NP_014177.1 6324107 855499 229095..229715 1 NC_001146.6 Transcription/RNA-processing factor that associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 of the RNA polymerase II C-terminal domain; affects start site selection in vivo; Ssu72p 229715 SSU72 855499 SSU72 Saccharomyces cerevisiae Ssu72p NP_014177.1 229095 D 4932 CDS NP_014178.1 6324108 855500 complement(231069..233696) 1 NC_001146.6 Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; binds to the RPR1 RNA subunit in RNase P; Pop1p 233696 POP1 855500 POP1 Saccharomyces cerevisiae Pop1p NP_014178.1 231069 R 4932 CDS NP_014179.1 6324109 855501 234414..235715 1 NC_001146.6 Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence; Ade12p 235715 ADE12 855501 ADE12 Saccharomyces cerevisiae Ade12p NP_014179.1 234414 D 4932 CDS NP_014180.1 6324110 855502 complement(235997..237664) 1 NC_001146.6 Mannosyltransferase, involved in N-linked glycosylation; catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation; Alg9p 237664 ALG9 855502 ALG9 Saccharomyces cerevisiae Alg9p NP_014180.1 235997 R 4932 CDS NP_014181.1 6324111 855503 238239..240002 1 NC_001146.6 Protein with DNA-dependent ATPase and ssDNA annealing activities involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); Mgs1p 240002 MGS1 855503 MGS1 Saccharomyces cerevisiae Mgs1p NP_014181.1 238239 D 4932 CDS NP_014182.1 6324112 855504 240332..241312 1 NC_001146.6 Ynl217wp 241312 855504 YNL217W Saccharomyces cerevisiae Ynl217wp NP_014182.1 240332 D 4932 CDS NP_014183.1 6324113 855505 241690..244173 1 NC_001146.6 Rap1p; DNA-binding protein involved in either activation or repression of transcription, depending on binding site context; also binds telomere sequences and plays a role in telomeric position effect (silencing) and telomere structure 244173 RAP1 855505 RAP1 Saccharomyces cerevisiae DNA-binding protein involved in either activation or repression of transcription, depending on binding site context; also binds telomere sequences and plays a role in telomeric position effect (silencing) and telomere structure NP_014183.1 241690 D 4932 CDS NP_014184.1 6324114 855506 244469..245431 1 NC_001146.6 Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; Ies2p 245431 IES2 855506 IES2 Saccharomyces cerevisiae Ies2p NP_014184.1 244469 D 4932 CDS NP_014185.1 6324115 855507 245618..246217 1 NC_001146.6 Pex17p; Peroxisomal membrane peroxin and subunit of the docking complex that facilitates the import of peroxisomal matrix proteins; required for peroxisome biogenesis 246217 PEX17 855507 PEX17 Saccharomyces cerevisiae Peroxisomal membrane peroxin and subunit of the docking complex that facilitates the import of peroxisomal matrix proteins; required for peroxisome biogenesis NP_014185.1 245618 D 4932 CDS NP_014186.1 6324116 855508 complement(246461..247105) 1 NC_001146.6 Ynl213cp; Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 247105 855508 YNL213C Saccharomyces cerevisiae Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_014186.1 246461 R 4932 CDS NP_014187.1 6324117 855509 247462..249810 1 NC_001146.6 Vid27p; Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth 249810 VID27 855509 VID27 Saccharomyces cerevisiae Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth NP_014187.1 247462 D 4932 CDS NP_014188.1 6324118 855510 complement(250056..250316) 1 NC_001146.6 Ynl211cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene 250316 855510 YNL211C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene NP_014188.1 250056 R 4932 CDS NP_014189.1 6324119 855511 250932..251744 1 NC_001146.6 Protein with RNA-binding motifs required for meiosis-specific mRNA splicing; required for chromosome pairing and meiotic recombination; Mer1p 251744 MER1 855511 MER1 Saccharomyces cerevisiae Mer1p NP_014189.1 250932 D 4932 CDS NP_014190.1 6324120 855512 252060..253901 1 NC_001146.6 Ssb2p; Cytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; homolog of SSB1 253901 SSB2 855512 SSB2 Saccharomyces cerevisiae Cytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; homolog of SSB1 NP_014190.1 252060 D 4932 CDS NP_014191.2 42742305 855513 254419..255018 1 NC_001146.6 Ynl208wp; Protein of unknown function; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; potential orthologs found in other fungi 255018 855513 YNL208W Saccharomyces cerevisiae Protein of unknown function; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; potential orthologs found in other fungi NP_014191.2 254419 D 4932 CDS NP_014192.1 6324122 855514 255354..256631 1 NC_001146.6 Rio2p; Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p 256631 RIO2 855514 RIO2 Saccharomyces cerevisiae Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p NP_014192.1 255354 D 4932 CDS NP_014193.1 6324123 855515 complement(256789..258156) 1 NC_001146.6 Rtt106p; Protein with a role in regulation of Ty1 transposition 258156 RTT106 855515 RTT106 Saccharomyces cerevisiae Protein with a role in regulation of Ty1 transposition NP_014193.1 256789 R 4932 CDS NP_014195.1 6324125 855517 complement(258376..259278) 1 NC_001146.6 Sps18p; Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation 259278 SPS18 855517 SPS18 Saccharomyces cerevisiae Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation NP_014195.1 258376 R 4932 CDS NP_014197.2 99030931 855518 259579..260457 1 NC_001146.6 Sps19p; Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate 260457 SPS19 855518 SPS19 Saccharomyces cerevisiae Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate NP_014197.2 259579 D 4932 CDS NP_014198.1 6324128 855520 complement(260628..263204) 1 NC_001146.6 Putative subunit of an evolutionarily conserved protein phosphatase complex containing the catalytic subunit Pph3p and the regulatory subunit Psy4p; required for cisplatin and oxaliplatin resistance; localizes to nucleus; Psy2p 263204 PSY2 855520 PSY2 Saccharomyces cerevisiae Psy2p NP_014198.1 260628 R 4932 CDS NP_014199.1 6324129 855521 complement(263714..264454) 1 NC_001146.6 Ynl200cp; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 264454 855521 YNL200C Saccharomyces cerevisiae Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_014199.1 263714 R 4932 CDS NP_014200.1 6324130 855522 complement(264927..266531) 1 NC_001146.6 Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p; Gcr2p 266531 GCR2 855522 GCR2 Saccharomyces cerevisiae Gcr2p NP_014200.1 264927 R 4932 CDS NP_014202.1 6324132 855524 complement(267609..269594) 1 NC_001146.6 Whi3p; RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci; cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start 269594 WHI3 855524 WHI3 Saccharomyces cerevisiae RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci; cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start NP_014202.1 267609 R 4932 CDS NP_014203.1 6324133 855525 complement(270276..271172) 1 NC_001146.6 Sporulation-specific protein with a leucine zipper motif; Slz1p 271172 SLZ1 855525 SLZ1 Saccharomyces cerevisiae Slz1p NP_014203.1 270276 R 4932 CDS NP_014204.2 42742306 855526 complement(271524..272309) 1 NC_001146.6 Ynl195cp; Putative protein of unknown function; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 272309 855526 YNL195C Saccharomyces cerevisiae Putative protein of unknown function; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_014204.2 271524 R 4932 CDS NP_014205.1 6324135 855527 complement(272711..273616) 1 NC_001146.6 Ynl194cp; Integral membrane protein localized to eisosomes; sporulation and plasma membrane sphingolipid content are altered in mutants; has homologs SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS 273616 855527 YNL194C Saccharomyces cerevisiae Integral membrane protein localized to eisosomes; sporulation and plasma membrane sphingolipid content are altered in mutants; has homologs SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS NP_014205.1 272711 R 4932 CDS NP_014206.1 6324136 855528 274369..276045 1 NC_001146.6 Ynl193wp; Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis 276045 855528 YNL193W Saccharomyces cerevisiae Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis NP_014206.1 274369 D 4932 CDS NP_014207.1 6324137 855529 276503..279898 1 NC_001146.6 Chs1p; Chitin synthase I, requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for repairing the chitin septum during cytokinesis; transcription activated by mating factor 279898 CHS1 855529 CHS1 Saccharomyces cerevisiae Chitin synthase I, requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for repairing the chitin septum during cytokinesis; transcription activated by mating factor NP_014207.1 276503 D 4932 CDS NP_014208.1 6324138 855530 280433..281506 1 NC_001146.6 Probable glutamine amidotransferase, forms a complex with Dug1p and Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p); Dug3p 281506 DUG3 855530 DUG3 Saccharomyces cerevisiae Dug3p NP_014208.1 280433 D 4932 CDS NP_014209.1 6324139 855531 282396..283010 1 NC_001146.6 Ynl190wp; Cell wall protein of unknown function; proposed role as a hydrophilin induced by osmotic stress; contains a putative GPI-attachment site 283010 855531 YNL190W Saccharomyces cerevisiae Cell wall protein of unknown function; proposed role as a hydrophilin induced by osmotic stress; contains a putative GPI-attachment site NP_014209.1 282396 D 4932 CDS NP_014210.1 6324140 855532 284261..285889 1 NC_001146.6 Srp1p; Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation 285889 SRP1 855532 SRP1 Saccharomyces cerevisiae Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation NP_014210.1 284261 D 4932 CDS NP_014211.1 6324141 855533 286309..287610 1 NC_001146.6 Kar1p; Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p 287610 KAR1 855533 KAR1 Saccharomyces cerevisiae Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p NP_014211.1 286309 D 4932 CDS NP_014212.1 6324142 855534 287996..289069 1 NC_001146.6 Ynl187wp; Putative protein of unknown function; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; may interact with or be fuctionally redundant with Prp40p 289069 855534 YNL187W Saccharomyces cerevisiae Putative protein of unknown function; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; may interact with or be fuctionally redundant with Prp40p NP_014212.1 287996 D 4932 CDS NP_014213.1 6324143 855535 289500..291878 1 NC_001146.6 Ubp10p; Ubiquitin-specific protease that deubiquitinates ubiquitin-protein moieties; may regulate silencing by acting on Sir4p; involved in posttranscriptionally regulating Gap1p and possibly other transporters; primarily located in the nucleus 291878 UBP10 855535 UBP10 Saccharomyces cerevisiae Ubiquitin-specific protease that deubiquitinates ubiquitin-protein moieties; may regulate silencing by acting on Sir4p; involved in posttranscriptionally regulating Gap1p and possibly other transporters; primarily located in the nucleus NP_014213.1 289500 D 4932 CDS NP_014214.1 6324144 855536 complement(292195..292671) 1 NC_001146.6 Mrpl19p; Mitochondrial ribosomal protein of the large subunit 292671 MRPL19 855536 MRPL19 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit NP_014214.1 292195 R 4932 CDS NP_014216.1 6324146 855538 complement(293139..295511) 1 NC_001146.6 Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; Npr1p 295511 NPR1 855538 NPR1 Saccharomyces cerevisiae Npr1p NP_014216.1 293139 R 4932 CDS NP_014217.1 6324147 855539 complement(295962..297629) 1 NC_001146.6 Ipi3p; Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; highly conserved and contains WD40 motifs; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles 297629 IPI3 855539 IPI3 Saccharomyces cerevisiae Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; highly conserved and contains WD40 motifs; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles NP_014217.1 295962 R 4932 CDS NP_014218.1 6324148 855540 298337..299560 1 NC_001146.6 Ynl181wp; Putative oxidoreductase; required for cell viability 299560 855540 YNL181W Saccharomyces cerevisiae Putative oxidoreductase; required for cell viability NP_014218.1 298337 D 4932 CDS NP_014219.1 6324149 855541 complement(299656..300651) 1 NC_001146.6 Rho5p; Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity 300651 RHO5 855541 RHO5 Saccharomyces cerevisiae Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity NP_014219.1 299656 R 4932 CDS NP_014221.1 6324151 855543 302682..303404 1 NC_001146.6 Rps3p; Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins 303404 RPS3 855543 RPS3 Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins NP_014221.1 302682 D 4932 CDS NP_014222.1 6324152 855544 complement(303688..304617) 1 NC_001146.6 Mrpl22p; Mitochondrial ribosomal protein of the large subunit 304617 MRPL22 855544 MRPL22 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit NP_014222.1 303688 R 4932 CDS NP_014223.1 6324153 855545 complement(305072..306982) 1 NC_001146.6 Ynl176cp; Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p 306982 855545 YNL176C Saccharomyces cerevisiae Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p NP_014223.1 305072 R 4932 CDS NP_014224.1 6324155 855547 complement(307403..308614) 1 NC_001146.6 Protein of unknown function, localizes to the nucleolus and nucleoplasm; contains an RNA recognition motif (RRM) and has similarity to Nop12p, which is required for processing of pre-18S rRNA; Nop13p 308614 NOP13 855547 NOP13 Saccharomyces cerevisiae Nop13p NP_014224.1 307403 R 4932 CDS NP_014226.1 6324156 855548 complement(308959..310059) 1 NC_001146.6 Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations; Mdg1p 310059 MDG1 855548 MDG1 Saccharomyces cerevisiae Mdg1p NP_014226.1 308959 R 4932 CDS NP_014227.1 6324157 855549 310638..315884 1 NC_001146.6 Largest subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; Apc1p 315884 APC1 855549 APC1 Saccharomyces cerevisiae Apc1p NP_014227.1 310638 D 4932 CDS NP_014230.1 6324160 855552 complement(316171..317673) 1 NC_001146.6 Psd1p; Phosphatidylserine decarboxylase of the mitochondrial inner membrane, converts phosphatidylserine to phosphatidylethanolamine 317673 PSD1 855552 PSD1 Saccharomyces cerevisiae Phosphatidylserine decarboxylase of the mitochondrial inner membrane, converts phosphatidylserine to phosphatidylethanolamine NP_014230.1 316171 R 4932 CDS NP_014231.1 6324161 855553 complement(318032..318811) 1 NC_001146.6 Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Fmp41p 318811 FMP41 855553 FMP41 Saccharomyces cerevisiae Fmp41p NP_014231.1 318032 R 4932 CDS NP_014232.1 6324162 855554 complement(319418..321361) 1 NC_001146.6 Sko1p; Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, forms a complex with Tup1p and Ssn6p to both activate and repress transcription; cytosolic and nuclear protein involved in osmotic and oxidative stress responses 321361 SKO1 855554 SKO1 Saccharomyces cerevisiae Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, forms a complex with Tup1p and Ssn6p to both activate and repress transcription; cytosolic and nuclear protein involved in osmotic and oxidative stress responses NP_014232.1 319418 R 4932 CDS NP_014233.1 6324163 855555 complement(322221..323567) 1 NC_001146.6 Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner; Bni5p 323567 BNI5 855555 BNI5 Saccharomyces cerevisiae Bni5p NP_014233.1 322221 R 4932 CDS NP_014234.1 6324164 855556 323834..325054 1 NC_001146.6 Ynl165wp; Putative protein of unknown function; YNL165W is not an essential gene 325054 855556 YNL165W Saccharomyces cerevisiae Putative protein of unknown function; YNL165W is not an essential gene NP_014234.1 323834 D 4932 CDS NP_014235.1 6324165 855557 complement(325267..326322) 1 NC_001146.6 Ibd2p; Component of the BUB2-dependent spindle checkpoint pathway, interacts with Bfa1p and functions upstream of Bub2p and Bfa1p 326322 IBD2 855557 IBD2 Saccharomyces cerevisiae Component of the BUB2-dependent spindle checkpoint pathway, interacts with Bfa1p and functions upstream of Bub2p and Bfa1p NP_014235.1 325267 R 4932 CDS NP_014236.1 6324166 855558 complement(326743..330075) 1 NC_001146.6 Ria1p; Cytoplasmic GTPase involved in biogenesis of the 60S ribosome; has similarity to translation elongation factor 2 (Eft1p and Eft2p) 330075 RIA1 855558 RIA1 Saccharomyces cerevisiae Cytoplasmic GTPase involved in biogenesis of the 60S ribosome; has similarity to translation elongation factor 2 (Eft1p and Eft2p) NP_014236.1 326743 R 4932 CDS NP_076906.1 13129184 855559 330331..330549 1 NC_001146.6 Ynl162w-ap; Putative protein of unknown function, identified by homology 330549 855559 YNL162W-A Saccharomyces cerevisiae Putative protein of unknown function, identified by homology NP_076906.1 330331 D 4932 CDS NP_014237.2 6681849 855560 join(331324..331327,331840..332156) 1 NC_001146.6 Rpl42ap; Protein component of the large (60S) ribosomal subunit, identical to Rpl42Bp and has similarity to rat L44 ribosomal protein 332156 RPL42A 855560 RPL42A Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, identical to Rpl42Bp and has similarity to rat L44 ribosomal protein NP_014237.2 331324 D 4932 CDS NP_014238.1 6324168 855561 332599..334869 1 NC_001146.6 Serine/threonine protein kinase that regulates cell morphogenesis pathways; involved in cell wall biosynthesis, apical growth, proper mating projection morphology, bipolar bud site selection in diploid cells, and cell separation; Cbk1p 334869 CBK1 855561 CBK1 Saccharomyces cerevisiae Cbk1p NP_014238.1 332599 D 4932 CDS NP_014239.1 6324169 855562 336547..337611 1 NC_001146.6 Ygp1p; Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p 337611 YGP1 855562 YGP1 Saccharomyces cerevisiae Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p NP_014239.1 336547 D 4932 CDS NP_014240.1 6324170 855563 complement(338480..339349) 1 NC_001146.6 Integral inner nuclear membrane protein that acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals; Asi2p 339349 ASI2 855563 ASI2 Saccharomyces cerevisiae Asi2p NP_014240.1 338480 R 4932 CDS NP_014241.1 6324171 855564 339614..340210 1 NC_001146.6 Pga1p; Essential protein required for maturation of Gas1p and Pho8p; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; has synthetic genetic interations with secretory pathway genes 340210 PGA1 855564 PGA1 Saccharomyces cerevisiae Essential protein required for maturation of Gas1p and Pho8p; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; has synthetic genetic interations with secretory pathway genes NP_014241.1 339614 D 4932 CDS NP_014242.1 6324172 855565 340354..340860 1 NC_001146.6 Igo1p 340860 IGO1 855565 IGO1 Saccharomyces cerevisiae Igo1p NP_014242.1 340354 D 4932 CDS NP_014243.1 6324173 855566 complement(341071..341970) 1 NC_001146.6 Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins; Nsg2p 341970 NSG2 855566 NSG2 Saccharomyces cerevisiae Nsg2p NP_014243.1 341071 R 4932 CDS NP_014244.1 6324174 855567 342518..343342 1 NC_001146.6 Ynl155wp; Putative protein of unknown function, contains DHHC domain, also predicted to have thiol-disulfide oxidoreductase active site 343342 855567 YNL155W Saccharomyces cerevisiae Putative protein of unknown function, contains DHHC domain, also predicted to have thiol-disulfide oxidoreductase active site NP_014244.1 342518 D 4932 CDS NP_014245.1 6324175 855568 complement(343638..345278) 1 NC_001146.6 Yck2p; Palmitoylated, plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck1p 345278 YCK2 855568 YCK2 Saccharomyces cerevisiae Palmitoylated, plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck1p NP_014245.1 343638 R 4932 CDS NP_014246.1 6324176 855569 complement(345671..346060) 1 NC_001146.6 Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it; Gim3p 346060 GIM3 855569 GIM3 Saccharomyces cerevisiae Gim3p NP_014246.1 345671 R 4932 CDS NP_014247.1 6324177 855570 346315..347544 1 NC_001146.6 Ynl152wp; Putative protein of unknown function; cytoplasmically localized protein proposed to function in phospholipid binding; YBL107C is an essential gene 347544 855570 YNL152W Saccharomyces cerevisiae Putative protein of unknown function; cytoplasmically localized protein proposed to function in phospholipid binding; YBL107C is an essential gene NP_014247.1 346315 D 4932 CDS NP_014248.1 6324178 855571 complement(347768..348523) 1 NC_001146.6 Rpc31p; RNA polymerase III subunit C31; contains HMG-like C-terminal domain 348523 RPC31 855571 RPC31 Saccharomyces cerevisiae RNA polymerase III subunit C31; contains HMG-like C-terminal domain NP_014248.1 347768 R 4932 CDS NP_014250.1 6324180 855573 complement(349369..349758) 1 NC_001146.6 Pga2p; Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect 349758 PGA2 855573 PGA2 Saccharomyces cerevisiae Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect NP_014250.1 349369 R 4932 CDS NP_014251.1 6324181 855574 complement(349909..350673) 1 NC_001146.6 Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance; Alf1p 350673 ALF1 855574 ALF1 Saccharomyces cerevisiae Alf1p NP_014251.1 349909 R 4932 CDS NP_014252.2 158267618 855575 join(350942..350959,351056..351385) 1 NC_001146.6 Lsm7p; Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA 351385 LSM7 855575 LSM7 Saccharomyces cerevisiae Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA NP_014252.2 350942 D 4932 CDS NP_878152.1 33438864 1466510 complement(351388..351582) 1 NC_001146.6 Ynl146c-ap; Putative protein of unknown function 351582 1466510 YNL146C-A Saccharomyces cerevisiae Putative protein of unknown function NP_878152.1 351388 R 4932 CDS NP_014253.1 6324183 855576 351717..352019 1 NC_001146.6 Ynl146wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNL146W is not an essential gene 352019 855576 YNL146W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNL146W is not an essential gene NP_014253.1 351717 D 4932 CDS NP_014254.1 6324184 855577 352416..352532 1 NC_001146.6 Mfa2p; Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA1 352532 MFA2 855577 MFA2 Saccharomyces cerevisiae Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA1 NP_014254.1 352416 D 4932 CDS NP_014255.1 6324185 855578 complement(352822..355044) 1 NC_001146.6 Ynl144cp; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene 355044 855578 YNL144C Saccharomyces cerevisiae Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene NP_014255.1 352822 R 4932 CDS NP_014257.1 6324187 855580 357455..358954 1 NC_001146.6 Mep2p; Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation 358954 MEP2 855580 MEP2 Saccharomyces cerevisiae Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation NP_014257.1 357455 D 4932 CDS NP_014258.1 6324188 855581 359598..360641 1 NC_001146.6 Adenine deaminase (adenine aminohydrolase), involved in purine salvage and nitrogen catabolism; Aah1p 360641 AAH1 855581 AAH1 Saccharomyces cerevisiae Aah1p NP_014258.1 359598 D 4932 CDS NP_014260.1 6324190 855583 complement(360926..365719) 1 NC_001146.6 Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids; Rlr1p 365719 RLR1 855583 RLR1 Saccharomyces cerevisiae Rlr1p NP_014260.1 360926 R 4932 CDS NP_878153.1 33438865 1466511 join(366035..366037,366160..366414) 1 NC_001146.6 Ysf3p; Component of the U2 snRNP, associated with the SF3b complex; conserved in Ashbya gossypii 366414 YSF3 1466511 YSF3 Saccharomyces cerevisiae Component of the U2 snRNP, associated with the SF3b complex; conserved in Ashbya gossypii NP_878153.1 366035 D 4932 CDS NP_014261.1 6324191 855584 366743..368323 1 NC_001146.6 Srv2p; CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis 368323 SRV2 855584 SRV2 Saccharomyces cerevisiae CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis NP_014261.1 366743 D 4932 CDS NP_014262.1 6324192 855585 complement(368597..370057) 1 NC_001146.6 Nam9p; Mitochondrial ribosomal component of the small subunit 370057 NAM9 855585 NAM9 Saccharomyces cerevisiae Mitochondrial ribosomal component of the small subunit NP_014262.1 368597 R 4932 CDS NP_014263.1 6324193 855586 370370..371647 1 NC_001146.6 Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A; Eaf7p 371647 EAF7 855586 EAF7 Saccharomyces cerevisiae Eaf7p NP_014263.1 370370 D 4932 CDS NP_014264.1 6324194 855587 complement(371884..372228) 1 NC_001146.6 Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function; Fpr1p 372228 FPR1 855587 FPR1 Saccharomyces cerevisiae Fpr1p NP_014264.1 371884 R 4932 CDS NP_014265.1 6324195 855588 complement(372453..373583) 1 NC_001146.6 Ynl134cp; Putative protein of unknown function with similarity to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced by the DNA-damaging agent MMS 373583 855588 YNL134C Saccharomyces cerevisiae Putative protein of unknown function with similarity to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced by the DNA-damaging agent MMS NP_014265.1 372453 R 4932 CDS NP_014266.1 6324196 855589 complement(374173..374694) 1 NC_001146.6 Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining; Fyv6p 374694 FYV6 855589 FYV6 Saccharomyces cerevisiae Fyv6p NP_014266.1 374173 R 4932 CDS NP_014267.1 6324197 855591 375323..378493 1 NC_001146.6 Kre33p; Essential protein of unknown function; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance 378493 KRE33 855591 KRE33 Saccharomyces cerevisiae Essential protein of unknown function; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance NP_014267.1 375323 D 4932 CDS NP_014268.1 6324198 855592 378769..379227 1 NC_001146.6 Tom22p; Component of the TOM (translocase of outer membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between the TOM and TIM complexes 379227 TOM22 855592 TOM22 Saccharomyces cerevisiae Component of the TOM (translocase of outer membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between the TOM and TIM complexes NP_014268.1 378769 D 4932 CDS NP_014269.2 42742307 855593 complement(join(379560..380691,380784..380833)) 1 NC_001146.6 Cpt1p; Cholinephosphotransferase, required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription 380833 CPT1 855593 CPT1 Saccharomyces cerevisiae Cholinephosphotransferase, required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription NP_014269.2 379560 R 4932 CDS NP_878154.1 33438866 1466512 complement(381247..381393) 1 NC_001146.6 Ynl130c-ap; Putative protein of unknown function 381393 1466512 YNL130C-A Saccharomyces cerevisiae Putative protein of unknown function NP_878154.1 381247 R 4932 CDS NP_014270.1 6324200 855594 381482..382204 1 NC_001146.6 Nrk1p; Nicotinamide riboside kinase, catalyzes the synthesis of nicotinamide nucleotide (NMN) from nicotinamide riboside; involved in a salvage pathway for NAD+ biosynthesis 382204 NRK1 855594 NRK1 Saccharomyces cerevisiae Nicotinamide riboside kinase, catalyzes the synthesis of nicotinamide nucleotide (NMN) from nicotinamide riboside; involved in a salvage pathway for NAD+ biosynthesis NP_014270.1 381482 D 4932 CDS NP_014271.1 6324201 855595 382361..383665 1 NC_001146.6 Tep1p; Homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 that has lipid phosphatase activity and is linked to the phosphatidylinositol signaling pathway; plays a role in normal sporulation 383665 TEP1 855595 TEP1 Saccharomyces cerevisiae Homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 that has lipid phosphatase activity and is linked to the phosphatidylinositol signaling pathway; plays a role in normal sporulation NP_014271.1 382361 D 4932 CDS NP_014272.1 6324202 855596 383989..386850 1 NC_001146.6 Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far10p; Far11p 386850 FAR11 855596 FAR11 Saccharomyces cerevisiae Far11p NP_014272.1 383989 D 4932 CDS NP_014273.1 6324203 855597 387229..389769 1 NC_001146.6 Spc98p; Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque 389769 SPC98 855597 SPC98 Saccharomyces cerevisiae Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque NP_014273.1 387229 D 4932 CDS NP_014274.1 6324204 855598 complement(390148..392169) 1 NC_001146.6 Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane; Esbp6p 392169 ESBP6 855598 ESBP6 Saccharomyces cerevisiae Esbp6p NP_014274.1 390148 R 4932 CDS NP_014275.1 6324205 855599 392894..394372 1 NC_001146.6 Protein required for the assembly of box H/ACA snoRNPs and for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; has similarity to Gar1p and other RNA-binding proteins; Naf1p 394372 NAF1 855599 NAF1 Saccharomyces cerevisiae Naf1p NP_014275.1 392894 D 4932 CDS NP_014276.1 6324206 855600 394687..397680 1 NC_001146.6 Protein of unknown function which may contribute to lipid homeostasis and/or apoptosis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases; Nma111p 397680 NMA111 855600 NMA111 Saccharomyces cerevisiae Nma111p NP_014276.1 394687 D 4932 CDS NP_014277.1 6324207 855601 complement(398025..398372) 1 NC_001146.6 Ynl122cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL122C is not an essential gene 398372 855601 YNL122C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL122C is not an essential gene NP_014277.1 398025 R 4932 CDS NP_014278.1 6324208 855602 complement(398686..400539) 1 NC_001146.6 Tom70p; Component (70 kDa) of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins 400539 TOM70 855602 TOM70 Saccharomyces cerevisiae Component (70 kDa) of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins NP_014278.1 398686 R 4932 CDS NP_014280.1 6324209 855603 401042..402523 1 NC_001146.6 Protein with a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; Ncs2p 402523 NCS2 855603 NCS2 Saccharomyces cerevisiae Ncs2p NP_014280.1 401042 D 4932 CDS NP_014281.1 6324211 855605 complement(402654..405566) 1 NC_001146.6 Dcp2p; Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; member of the Nudix hydrolase family 405566 DCP2 855605 DCP2 Saccharomyces cerevisiae Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; member of the Nudix hydrolase family NP_014281.1 402654 R 4932 CDS NP_014282.1 6324212 855606 406360..408024 1 NC_001146.6 Mls1p; Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium 408024 MLS1 855606 MLS1 Saccharomyces cerevisiae Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium NP_014282.1 406360 D 4932 CDS NP_014283.1 6324213 855607 408343..409911 1 NC_001146.6 Protein involved in regulating spindle position and orientation, functionally redundant with Dma1p; homolog of S. pombe Dma1 and H. sapiens Chfr; Dma2p 409911 DMA2 855607 DMA2 Saccharomyces cerevisiae Dma2p NP_014283.1 408343 D 4932 CDS NP_014284.1 6324214 855608 complement(410121..412055) 1 NC_001146.6 Ynl115cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene 412055 855608 YNL115C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene NP_014284.1 410121 R 4932 CDS NP_014286.1 6324215 855609 412773..413201 1 NC_001146.6 Rpc19p; RNA polymerase subunit, common to RNA polymerases I and III 413201 RPC19 855609 RPC19 Saccharomyces cerevisiae RNA polymerase subunit, common to RNA polymerases I and III NP_014286.1 412773 D 4932 CDS NP_014287.1 6324217 855611 join(413641..414913,415916..416283) 1 NC_001146.6 Essential ATP-dependent RNA helicase of the DEAD-box protein family, involved in nonsense-mediated mRNA decay and rRNA processing; Dbp2p 416283 DBP2 855611 DBP2 Saccharomyces cerevisiae Dbp2p NP_014287.1 413641 D 4932 CDS NP_014288.1 6324218 855612 complement(416942..417304) 1 NC_001146.6 Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; required for sterol C5-6 and fatty acid desaturation; Cyb5p 417304 CYB5 855612 CYB5 Saccharomyces cerevisiae Cyb5p NP_014288.1 416942 R 4932 CDS NP_014289.1 6324219 855613 complement(417828..418490) 1 NC_001146.6 Nop15p; Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm 418490 NOP15 855613 NOP15 Saccharomyces cerevisiae Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm NP_014289.1 417828 R 4932 CDS NP_014291.1 6324221 855615 complement(419016..419828) 1 NC_001146.6 Ynl108cp; Putative protein of unknown function with similarity to Tfc7p and prokaryotic phosphotransfer enzymes; null mutant shows alterations in glucose metabolism; GFP-fusion protein localizes to the cytoplasm and nucleus 419828 855615 YNL108C Saccharomyces cerevisiae Putative protein of unknown function with similarity to Tfc7p and prokaryotic phosphotransfer enzymes; null mutant shows alterations in glucose metabolism; GFP-fusion protein localizes to the cytoplasm and nucleus NP_014291.1 419016 R 4932 CDS NP_014292.1 6324222 855616 420100..420780 1 NC_001146.6 Yaf9p; Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain 420780 YAF9 855616 YAF9 Saccharomyces cerevisiae Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain NP_014292.1 420100 D 4932 CDS NP_014293.1 6324224 855618 complement(420946..424497) 1 NC_001146.6 Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain; Inp52p 424497 INP52 855618 INP52 Saccharomyces cerevisiae Inp52p NP_014293.1 420946 R 4932 CDS NP_014295.1 6324225 855619 complement(424897..426756) 1 NC_001146.6 Leu4p; Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway 426756 LEU4 855619 LEU4 Saccharomyces cerevisiae Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway NP_014295.1 424897 R 4932 CDS NP_014296.2 117937806 855620 427737..429755 1 NC_001146.6 Met4p; Lecine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p 429755 MET4 855620 MET4 Saccharomyces cerevisiae Lecine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p NP_014296.2 427737 D 4932 CDS NP_014297.1 6324227 855621 430089..434495 1 NC_001146.6 Pol1p; Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis 434495 POL1 855621 POL1 Saccharomyces cerevisiae Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis NP_014297.1 430089 D 4932 CDS NP_014298.1 6324228 855622 435001..437142 1 NC_001146.6 Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; Avt4p 437142 AVT4 855622 AVT4 Saccharomyces cerevisiae Avt4p NP_014298.1 435001 D 4932 CDS NP_014299.1 6324229 855623 437615..438319 1 NC_001146.6 Putative protein of unknown function; non-tagged protein is detected in purified mitochondria; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media; Aim37p 438319 AIM37 855623 AIM37 Saccharomyces cerevisiae Aim37p NP_014299.1 437615 D 4932 CDS NP_014300.1 6324230 855624 complement(438569..439285) 1 NC_001146.6 Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA; Oca1p 439285 OCA1 855624 OCA1 Saccharomyces cerevisiae Oca1p NP_014300.1 438569 R 4932 CDS NP_014301.1 6324231 855625 complement(439604..440572) 1 NC_001146.6 Ras2p; GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes 440572 RAS2 855625 RAS2 Saccharomyces cerevisiae GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes NP_014301.1 439604 R 4932 CDS NP_878155.1 33438867 1466513 complement(440799..440921) 1 NC_001146.6 Ynl097c-bp; Putative protein of unknown function 440921 1466513 YNL097C-B Saccharomyces cerevisiae Putative protein of unknown function NP_878155.1 440799 R 4932 CDS NP_014302.1 6324232 855626 complement(441368..442360) 1 NC_001146.6 Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; C-terminus has similarity to human candidate tumor suppressor p33(ING1); Pho23p 442360 PHO23 855626 PHO23 Saccharomyces cerevisiae Pho23p NP_014302.1 441368 R 4932 CDS NP_014303.1 6324233 855628 complement(join(443400..443828,444174..444317)) 1 NC_001146.6 Rps7bp; Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Ap; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins 444317 RPS7B 855628 RPS7B Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Ap; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins NP_014303.1 443400 R 4932 CDS NP_014304.1 6324234 855629 complement(444914..446842) 1 NC_001146.6 Ynl095cp; Putative protein of unknown function predicted to contain a transmembrane domain; YNL095C is not an essential gene 446842 855629 YNL095C Saccharomyces cerevisiae Putative protein of unknown function predicted to contain a transmembrane domain; YNL095C is not an essential gene NP_014304.1 444914 R 4932 CDS NP_014305.1 6324235 855630 447613..449376 1 NC_001146.6 Protein of unknown function, interacts with Rvs161p and Rvs167p; computational analysis of protein-protein interactions in large-scale studies suggests a possible role in actin filament organization; App1p 449376 APP1 855630 APP1 Saccharomyces cerevisiae App1p NP_014305.1 447613 D 4932 CDS NP_014306.1 6324236 855631 449870..450532 1 NC_001146.6 Ypt53p; GTPase, similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis 450532 YPT53 855631 YPT53 Saccharomyces cerevisiae GTPase, similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis NP_014306.1 449870 D 4932 CDS NP_014307.1 6324237 855632 450873..452075 1 NC_001146.6 Ynl092wp; Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene 452075 855632 YNL092W Saccharomyces cerevisiae Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene NP_014307.1 450873 D 4932 CDS NP_014308.1 6324238 855633 452410..456132 1 NC_001146.6 Protein of unknown function, mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1; Nst1p 456132 NST1 855633 NST1 Saccharomyces cerevisiae Nst1p NP_014308.1 452410 D 4932 CDS NP_014309.1 6324239 855634 456567..457145 1 NC_001146.6 Rho2p; Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly 457145 RHO2 855634 RHO2 Saccharomyces cerevisiae Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly NP_014309.1 456567 D 4932 CDS NP_014311.1 6324241 855636 457706..461992 1 NC_001146.6 Top2p; Essential type II topoisomerase, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis 461992 TOP2 855636 TOP2 Saccharomyces cerevisiae Essential type II topoisomerase, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis NP_014311.1 457706 D 4932 CDS NP_014312.1 6324242 855637 462413..465949 1 NC_001146.6 Tcb2p; Bud-specific protein with a potential role in membrane trafficking; GFP-fusion protein migrates from the cell surface to intracellular vesicles near vacuole; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud 465949 TCB2 855637 TCB2 Saccharomyces cerevisiae Bud-specific protein with a potential role in membrane trafficking; GFP-fusion protein migrates from the cell surface to intracellular vesicles near vacuole; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud NP_014312.1 462413 D 4932 CDS NP_014313.1 6324243 855638 466336..466644 1 NC_001146.6 Ynl086wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to endosomes 466644 855638 YNL086W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to endosomes NP_014313.1 466336 D 4932 CDS NP_014314.1 6324244 855639 467133..469625 1 NC_001146.6 Protein that forms a complex with Pbp1p that may mediate posttranscriptional regulation of HO endonuclease; involved in propagation of M2 dsRNA satellite of L-A virus; contains a DTG signature typical of retroviral proteases; Mkt1p 469625 MKT1 855639 MKT1 Saccharomyces cerevisiae Mkt1p NP_014314.1 467133 D 4932 CDS NP_014315.1 6324245 855640 complement(470055..471104) 1 NC_001146.6 End3p; EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p 471104 END3 855640 END3 Saccharomyces cerevisiae EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p NP_014315.1 470055 R 4932 CDS NP_014316.2 42742308 855641 471379..473016 1 NC_001146.6 Sal1p; Probable transporter, member of the Ca2+-binding subfamily of the mitochondrial carrier family, with two EF-hand motifs; Pet9p and Sal1p have an overlapping function critical for viability; polymorphic in different S. cerevisiae strains 473016 SAL1 855641 SAL1 Saccharomyces cerevisiae Probable transporter, member of the Ca2+-binding subfamily of the mitochondrial carrier family, with two EF-hand motifs; Pet9p and Sal1p have an overlapping function critical for viability; polymorphic in different S. cerevisiae strains NP_014316.2 471379 D 4932 CDS NP_014317.2 46562124 855642 473392..476013 1 NC_001146.6 Pms1p; ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL 476013 PMS1 855642 PMS1 Saccharomyces cerevisiae ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL NP_014317.2 473392 D 4932 CDS NP_014318.1 6324248 855643 complement(476189..476620) 1 NC_001146.6 Sws2p; Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency 476620 SWS2 855643 SWS2 Saccharomyces cerevisiae Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency NP_014318.1 476189 R 4932 CDS NP_014319.1 6324249 855644 complement(476933..478033) 1 NC_001146.6 Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene; Eos1p 478033 EOS1 855644 EOS1 Saccharomyces cerevisiae Eos1p NP_014319.1 476933 R 4932 CDS NP_014320.1 6324250 855645 complement(478567..479166) 1 NC_001146.6 Tpm1p; Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently 479166 TPM1 855645 TPM1 Saccharomyces cerevisiae Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently NP_014320.1 478567 R 4932 CDS NP_014321.1 6324251 855646 479769..480992 1 NC_001146.6 Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network; Nis1p 480992 NIS1 855646 NIS1 Saccharomyces cerevisiae Nis1p NP_014321.1 479769 D 4932 CDS NP_014322.1 6324252 855647 481392..482978 1 NC_001146.6 Putative chaperone of the HSP40 (DNAJ) family; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Apj1p 482978 APJ1 855647 APJ1 Saccharomyces cerevisiae Apj1p NP_014322.1 481392 D 4932 CDS NP_014323.1 6324253 855648 483557..485311 1 NC_001146.6 Pleiotropic negative transcriptional regulator involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling; Mks1p 485311 MKS1 855648 MKS1 Saccharomyces cerevisiae Mks1p NP_014323.1 483557 D 4932 CDS NP_014324.1 6324254 855649 485608..486480 1 NC_001146.6 Imp4p; Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs 486480 IMP4 855649 IMP4 Saccharomyces cerevisiae Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs NP_014324.1 485608 D 4932 CDS NP_014325.1 6324255 855650 complement(486767..488125) 1 NC_001146.6 Serine-rich protein of unknown function; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide; Mlf3p 488125 MLF3 855650 MLF3 Saccharomyces cerevisiae Mlf3p NP_014325.1 486767 R 4932 CDS NP_014326.1 6324256 855651 488387..490117 1 NC_001146.6 Msk1p; Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria 490117 MSK1 855651 MSK1 Saccharomyces cerevisiae Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria NP_014326.1 488387 D 4932 CDS NP_014327.1 6324257 855652 490318..491241 1 NC_001146.6 Rnh201p; Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis; cooperates with Rad27p nuclease 491241 RNH201 855652 RNH201 Saccharomyces cerevisiae Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis; cooperates with Rad27p nuclease NP_014327.1 490318 D 4932 CDS NP_014328.1 6324258 855653 491524..492972 1 NC_001146.6 Lat1p; Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA 492972 LAT1 855653 LAT1 Saccharomyces cerevisiae Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA NP_014328.1 491524 D 4932 CDS NP_014329.1 6324259 855654 493367..493549 1 NC_001146.6 Tom7p; Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex 493549 TOM7 855654 TOM7 Saccharomyces cerevisiae Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex NP_014329.1 493367 D 4932 CDS NP_014330.1 6324260 855655 complement(join(493957..494525,494975..495002)) 1 NC_001146.6 Rpl16bp; N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Ap, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p 495002 RPL16B 855655 RPL16B Saccharomyces cerevisiae N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Ap, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p NP_014330.1 493957 R 4932 CDS NP_014331.1 6324261 855656 complement(495702..498290) 1 NC_001146.6 Forkhead family transcription factor with a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase; Fkh2p 498290 FKH2 855656 FKH2 Saccharomyces cerevisiae Fkh2p NP_014331.1 495702 R 4932 CDS NP_878156.1 33438868 1466514 499418..499558 1 NC_001146.6 Ynl067w-bp; Putative protein of unknown function 499558 1466514 YNL067W-B Saccharomyces cerevisiae Putative protein of unknown function NP_878156.1 499418 D 4932 CDS NP_014332.1 6324262 855658 499682..500257 1 NC_001146.6 Rpl9bp; Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Ap and has similarity to E. coli L6 and rat L9 ribosomal proteins 500257 RPL9B 855658 RPL9B Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Ap and has similarity to E. coli L6 and rat L9 ribosomal proteins NP_014332.1 499682 D 4932 CDS NP_014333.1 6324263 855659 501516..502778 1 NC_001146.6 Sun4p; Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family 502778 SUN4 855659 SUN4 Saccharomyces cerevisiae Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family NP_014333.1 501516 D 4932 CDS NP_014334.1 6324264 855660 503725..505485 1 NC_001146.6 Plasma membrane multidrug transporter of the major facilitator superfamily, confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; Aqr1p 505485 AQR1 855660 AQR1 Saccharomyces cerevisiae Aqr1p NP_014334.1 503725 D 4932 CDS NP_014335.1 6324265 855661 complement(505869..507098) 1 NC_001146.6 Ydj1p; Protein chaperone involved in regulation of the HSP90 and HSP70 functions; involved in protein translocation across membranes; member of the DnaJ family 507098 YDJ1 855661 YDJ1 Saccharomyces cerevisiae Protein chaperone involved in regulation of the HSP90 and HSP70 functions; involved in protein translocation across membranes; member of the DnaJ family NP_014335.1 505869 R 4932 CDS NP_014336.1 6324266 855662 507759..508703 1 NC_001146.6 S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene; Mtq1p 508703 MTQ1 855662 MTQ1 Saccharomyces cerevisiae Mtq1p NP_014336.1 507759 D 4932 CDS NP_014337.1 6324267 855663 complement(508777..510213) 1 NC_001146.6 Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression; Gcd10p 510213 GCD10 855663 GCD10 Saccharomyces cerevisiae Gcd10p NP_014337.1 508777 R 4932 CDS NP_014338.1 6324268 855664 510541..512397 1 NC_001146.6 Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles; Nop2p 512397 NOP2 855664 NOP2 Saccharomyces cerevisiae Nop2p NP_014338.1 510541 D 4932 CDS NP_014339.1 6324269 855665 complement(512669..514936) 1 NC_001146.6 Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; Arp5p 514936 ARP5 855665 ARP5 Saccharomyces cerevisiae Arp5p NP_014339.1 512669 R 4932 CDS NP_014340.1 6324271 855667 complement(515764..516714) 1 NC_001146.6 Ynl058cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL058C is not an essential gene 516714 855667 YNL058C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL058C is not an essential gene NP_014340.1 515764 R 4932 CDS NP_014342.1 6324272 855668 517250..517843 1 NC_001146.6 Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene; Oca2p 517843 OCA2 855668 OCA2 Saccharomyces cerevisiae Oca2p NP_014342.1 517250 D 4932 CDS NP_014343.1 6324273 855669 complement(517995..518846) 1 NC_001146.6 Por1p; Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated 518846 POR1 855669 POR1 Saccharomyces cerevisiae Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated NP_014343.1 517995 R 4932 CDS NP_058180.1 7839195 855671 519457..520779 1 NC_001146.6 Ynl054w-ap; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 520779 855671 YNL054W-A Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_058180.1 519457 D 4932 CDS NP_014344.1 6324274 855673 526087..529584 1 NC_001146.6 Vac7p; Integral vacuolar membrane protein involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock 529584 VAC7 855673 VAC7 Saccharomyces cerevisiae Integral vacuolar membrane protein involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock NP_014344.1 526087 D 4932 CDS NP_014345.1 6324275 855674 529943..531412 1 NC_001146.6 Msg5p; Dual-specificity protein phosphatase required for maintenance of a low level of signaling through the cell integrity pathway; regulates and is regulated by Slt2p; dephosphorylates Fus3p; required for adaptive response to pheromone 531412 MSG5 855674 MSG5 Saccharomyces cerevisiae Dual-specificity protein phosphatase required for maintenance of a low level of signaling through the cell integrity pathway; regulates and is regulated by Slt2p; dephosphorylates Fus3p; required for adaptive response to pheromone NP_014345.1 529943 D 4932 CDS NP_014346.1 6324276 855675 531726..532187 1 NC_001146.6 Subunit Va of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth; Cox5ap 532187 COX5A 855675 COX5A Saccharomyces cerevisiae Cox5ap NP_014346.1 531726 D 4932 CDS NP_014347.1 6324277 855676 532660..533871 1 NC_001146.6 Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; Cog5p 533871 COG5 855676 COG5 Saccharomyces cerevisiae Cog5p NP_014347.1 532660 D 4932 CDS NP_014348.1 6324278 855677 complement(join(534080..534875,534967..534983)) 1 NC_001146.6 Ynl050cp; Putative protein of unknown function; YNL050c is not an essential gene 534983 855677 YNL050C Saccharomyces cerevisiae Putative protein of unknown function; YNL050c is not an essential gene NP_014348.1 534080 R 4932 CDS NP_014349.1 6324279 855678 complement(535282..537912) 1 NC_001146.6 Sfb2p; Probable component of COPII coated vesicles that binds to Sec23p; similar to and functionally redundant with Sec24p, but expressed at low levels; involved in ER to Golgi transport and in autophagy 537912 SFB2 855678 SFB2 Saccharomyces cerevisiae Probable component of COPII coated vesicles that binds to Sec23p; similar to and functionally redundant with Sec24p, but expressed at low levels; involved in ER to Golgi transport and in autophagy NP_014349.1 535282 R 4932 CDS NP_014350.1 6324280 855679 538174..539820 1 NC_001146.6 Alpha-1,2-mannosyltransferase, catalyzes sequential addition of the two terminal alpha 1,2-mannose residues to the Man5GlcNAc2-PP-dolichol intermediate during asparagine-linked glycosylation in the ER; Alg11p 539820 ALG11 855679 ALG11 Saccharomyces cerevisiae Alg11p NP_014350.1 538174 D 4932 CDS NP_014351.1 6324281 855680 complement(539912..541882) 1 NC_001146.6 Slm2p; Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; subunit of and phosphorylated by the TORC2 complex 541882 SLM2 855680 SLM2 Saccharomyces cerevisiae Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; subunit of and phosphorylated by the TORC2 complex NP_014351.1 539912 R 4932 CDS NP_014352.1 6324282 855681 542305..542823 1 NC_001146.6 Ynl046wp; Putative protein of unknown function; expression depends on Swi5p; GFP-fusion protein localizes to the endoplasmic reticulum; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) 542823 855681 YNL046W Saccharomyces cerevisiae Putative protein of unknown function; expression depends on Swi5p; GFP-fusion protein localizes to the endoplasmic reticulum; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) NP_014352.1 542305 D 4932 CDS NP_014353.1 6324283 855682 542964..544979 1 NC_001146.6 Ynl045wp; Leucyl aminopeptidase (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; role in vivo is not defined; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus 544979 855682 YNL045W Saccharomyces cerevisiae Leucyl aminopeptidase (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; role in vivo is not defined; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus NP_014353.1 542964 D 4932 CDS NP_014354.2 6681850 855683 join(545269..545292,545372..545878) 1 NC_001146.6 Yip3p; Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p 545878 YIP3 855683 YIP3 Saccharomyces cerevisiae Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p NP_014354.2 545269 D 4932 CDS NP_878157.1 33438869 1466515 547114..547371 1 NC_001146.6 Ynl042w-bp; Putative protein of unknown function 547371 1466515 YNL042W-B Saccharomyces cerevisiae Putative protein of unknown function NP_878157.1 547114 D 4932 CDS NP_014356.1 6324286 855686 548101..549291 1 NC_001146.6 Protein of unknown function, potential Cdc28p substrate; overproduction suppresses a pam1 slv3 double null mutation and confers resistance to methylmercury; Bop3p 549291 BOP3 855686 BOP3 Saccharomyces cerevisiae Bop3p NP_014356.1 548101 D 4932 CDS NP_014357.1 6324287 855687 complement(549469..551988) 1 NC_001146.6 Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; Cog6p 551988 COG6 855687 COG6 Saccharomyces cerevisiae Cog6p NP_014357.1 549469 R 4932 CDS NP_014358.1 6324288 855688 553381..554751 1 NC_001146.6 Ynl040wp; Putative protein of unknown function with strong similarity to alanyl-tRNA synthases from Eubacteria; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL040W is not an essential gene 554751 855688 YNL040W Saccharomyces cerevisiae Putative protein of unknown function with strong similarity to alanyl-tRNA synthases from Eubacteria; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL040W is not an essential gene NP_014358.1 553381 D 4932 CDS NP_014359.1 6324289 855689 555049..556833 1 NC_001146.6 Essential subunit of RNA polymerase III transcription factor (TFIIIB), which is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs; Bdp1p 556833 BDP1 855689 BDP1 Saccharomyces cerevisiae Bdp1p NP_014359.1 555049 D 4932 CDS NP_014360.2 37362689 855690 join(557021..557611,557686..557784) 1 NC_001146.6 Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein; Gpi15p 557784 GPI15 855690 GPI15 Saccharomyces cerevisiae Gpi15p NP_014360.2 557021 D 4932 CDS NP_014361.1 6324291 855691 complement(557921..559003) 1 NC_001146.6 Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; Idh1p 559003 IDH1 855691 IDH1 Saccharomyces cerevisiae Idh1p NP_014361.1 557921 R 4932 CDS NP_014362.1 6324292 855692 559815..560480 1 NC_001146.6 Nce103p; Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway 560480 NCE103 855692 NCE103 Saccharomyces cerevisiae Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway NP_014362.1 559815 D 4932 CDS NP_014363.1 6324293 855695 complement(568523..569692) 1 NC_001146.6 Ynl035cp; Putative protein of unknown function with similarity to proteins containing WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene 569692 855695 YNL035C Saccharomyces cerevisiae Putative protein of unknown function with similarity to proteins containing WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene NP_014363.1 568523 R 4932 CDS NP_014364.1 6324294 855697 570478..572316 1 NC_001146.6 Ynl034wp; Putative protein of unknown function; YNL034W is not an essential gene 572316 855697 YNL034W Saccharomyces cerevisiae Putative protein of unknown function; YNL034W is not an essential gene NP_014364.1 570478 D 4932 CDS NP_014365.1 6324295 855698 573000..573854 1 NC_001146.6 Ynl033wp; Putative protein of unknown function 573854 855698 YNL033W Saccharomyces cerevisiae Putative protein of unknown function NP_014365.1 573000 D 4932 CDS NP_014366.1 6324296 855699 574507..575352 1 NC_001146.6 Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm; Siw14p 575352 SIW14 855699 SIW14 Saccharomyces cerevisiae Siw14p NP_014366.1 574507 D 4932 CDS NP_014367.1 6324297 855700 complement(575641..576051) 1 NC_001146.6 One of two identical histone H3 proteins (see also HHT1); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation; Hht2p 576051 HHT2 855700 HHT2 Saccharomyces cerevisiae Hht2p NP_014367.1 575641 R 4932 CDS NP_014368.1 6324298 855701 576728..577039 1 NC_001146.6 One of two identical histone H4 proteins (see also HHF1); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity; Hhf2p 577039 HHF2 855701 HHF2 Saccharomyces cerevisiae Hhf2p NP_014368.1 576728 D 4932 CDS NP_014369.1 6324300 855703 complement(577206..578774) 1 NC_001146.6 Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Ktr5p 578774 KTR5 855703 KTR5 Saccharomyces cerevisiae Ktr5p NP_014369.1 577206 R 4932 CDS NP_014371.1 6324301 855704 579581..581617 1 NC_001146.6 Transcription factor that activates transcription of genes involved in stress response; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; Crz1p 581617 CRZ1 855704 CRZ1 Saccharomyces cerevisiae Crz1p NP_014371.1 579581 D 4932 CDS NP_014372.1 6324302 855705 581921..583375 1 NC_001146.6 Sam50p; Essential component of the Sorting and Assembly Machinery (SAM or Tob complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85 583375 SAM50 855705 SAM50 Saccharomyces cerevisiae Essential component of the Sorting and Assembly Machinery (SAM or Tob complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85 NP_014372.1 581921 D 4932 CDS NP_014373.1 6324303 855706 complement(584321..585292) 1 NC_001146.6 Ssn8p; Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance 585292 SSN8 855706 SSN8 Saccharomyces cerevisiae Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance NP_014373.1 584321 R 4932 CDS NP_878158.1 33438870 1466516 complement(586603..586821) 1 NC_001146.6 Ynl024c-ap; Putative protein of unknown function; YNL024C-A is an essential gene 586821 1466516 YNL024C-A Saccharomyces cerevisiae Putative protein of unknown function; YNL024C-A is an essential gene NP_878158.1 586603 R 4932 CDS NP_014374.1 6324304 855707 complement(587108..587848) 1 NC_001146.6 Ynl024cp; Putative protein of unknown function with seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL024C is not an essential gene 587848 855707 YNL024C Saccharomyces cerevisiae Putative protein of unknown function with seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL024C is not an essential gene NP_014374.1 587108 R 4932 CDS NP_014375.1 6324305 855708 complement(588264..591161) 1 NC_001146.6 Protein that binds to Fpr1p (FKBP12), conferring rapamycin resistance by competing with rapamycin for Fpr1p binding; has similarity to putative transcription factors, including D. melanogaster shuttle craft and human NFX1; Fap1p 591161 FAP1 855708 FAP1 Saccharomyces cerevisiae Fap1p NP_014375.1 588264 R 4932 CDS NP_014376.1 6324306 855709 complement(591428..592900) 1 NC_001146.6 Ynl022cp; Putative protein of unknown function with seven beta-strand methyltransferase motif similar to NOP2/YNL061W; green fluorescent protein (GFP)-fusion protein localizes to a single spot in the nucleus; YNL022C is not an essential gene 592900 855709 YNL022C Saccharomyces cerevisiae Putative protein of unknown function with seven beta-strand methyltransferase motif similar to NOP2/YNL061W; green fluorescent protein (GFP)-fusion protein localizes to a single spot in the nucleus; YNL022C is not an essential gene NP_014376.1 591428 R 4932 CDS NP_014377.1 6324307 855710 593228..595348 1 NC_001146.6 Putative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylation; Hda1p 595348 HDA1 855710 HDA1 Saccharomyces cerevisiae Hda1p NP_014377.1 593228 D 4932 CDS NP_014378.1 6324308 855711 complement(595624..597540) 1 NC_001146.6 Serine/threonine protein kinase involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis; Ark1p 597540 ARK1 855711 ARK1 Saccharomyces cerevisiae Ark1p NP_014378.1 595624 R 4932 CDS NP_014379.1 6324309 855712 complement(598377..599231) 1 NC_001146.6 Ynl019cp; Putative protein of unknown function 599231 855712 YNL019C Saccharomyces cerevisiae Putative protein of unknown function NP_014379.1 598377 R 4932 CDS NP_014380.1 6324310 855713 complement(599937..601775) 1 NC_001146.6 Ynl018cp; Putative protein of unknown function 601775 855713 YNL018C Saccharomyces cerevisiae Putative protein of unknown function NP_014380.1 599937 R 4932 CDS NP_014382.1 6324312 855716 602908..604269 1 NC_001146.6 Pub1p; Poly(A)+ RNA-binding protein, abundant mRNP-component protein that binds mRNA and is required for stability of a number of mRNAs; not reported to associate with polyribosomes 604269 PUB1 855716 PUB1 Saccharomyces cerevisiae Poly(A)+ RNA-binding protein, abundant mRNP-component protein that binds mRNA and is required for stability of a number of mRNAs; not reported to associate with polyribosomes NP_014382.1 602908 D 4932 CDS NP_014383.1 6324313 855717 605385..605612 1 NC_001146.6 Pbi2p; Cytosolic inhibitor of vacuolar proteinase B, required for efficient vacuole inheritance; with thioredoxin forms protein complex LMA1, which assists in priming SNARE molecules and promotes vacuole fusion 605612 PBI2 855717 PBI2 Saccharomyces cerevisiae Cytosolic inhibitor of vacuolar proteinase B, required for efficient vacuole inheritance; with thioredoxin forms protein complex LMA1, which assists in priming SNARE molecules and promotes vacuole fusion NP_014383.1 605385 D 4932 CDS NP_014384.1 6324314 855718 606320..609454 1 NC_001146.6 Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells; Hef3p 609454 HEF3 855718 HEF3 Saccharomyces cerevisiae Hef3p NP_014384.1 606320 D 4932 CDS NP_014386.2 9755342 855720 join(609687..609791,609876..611666) 1 NC_001146.6 Spo1p; Meiosis-specific protein with similarity to phospholipase B, required for meiotic spindle pole body duplication and separation; required for spore formation 611666 SPO1 855720 SPO1 Saccharomyces cerevisiae Meiosis-specific protein with similarity to phospholipase B, required for meiotic spindle pole body duplication and separation; required for spore formation NP_014386.2 609687 D 4932 CDS NP_014387.1 6324317 855721 complement(611837..613171) 1 NC_001146.6 Ynl011cp; Putative protein of unknown function; YNL011C is not an essential gene 613171 855721 YNL011C Saccharomyces cerevisiae Putative protein of unknown function; YNL011C is not an essential gene NP_014387.1 611837 R 4932 CDS NP_014388.1 6324318 855722 613636..614361 1 NC_001146.6 Ynl010wp; Putative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation 614361 855722 YNL010W Saccharomyces cerevisiae Putative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation NP_014388.1 613636 D 4932 CDS NP_014389.1 6324319 855723 614822..616084 1 NC_001146.6 Peroxisomal NADP-dependent isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids; Idp3p 616084 IDP3 855723 IDP3 Saccharomyces cerevisiae Idp3p NP_014389.1 614822 D 4932 CDS NP_014390.1 6324320 855724 complement(616212..618221) 1 NC_001146.6 Putative integral membrane E3 ubiquitin ligase; acts with Asi1p and Asi2p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals; Asi3p 618221 ASI3 855724 ASI3 Saccharomyces cerevisiae Asi3p NP_014390.1 616212 R 4932 CDS NP_014391.1 6324321 855725 complement(618509..619567) 1 NC_001146.6 Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; not functionally redundant with Ydj1p due to due to substrate specificity; shares similarity with bacterial DnaJ proteins; Sis1p 619567 SIS1 855725 SIS1 Saccharomyces cerevisiae Sis1p NP_014391.1 618509 R 4932 CDS NP_014392.1 6324322 855726 620069..620980 1 NC_001146.6 Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat; Lst8p 620980 LST8 855726 LST8 Saccharomyces cerevisiae Lst8p NP_014392.1 620069 D 4932 CDS NP_014393.1 6324323 855727 complement(621315..622430) 1 NC_001146.6 Mrp7p; Mitochondrial ribosomal protein of the large subunit 622430 MRP7 855727 MRP7 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit NP_014393.1 621315 R 4932 CDS NP_014394.2 154199622 855728 join(622917..622946,623289..624623) 1 NC_001146.6 Poly(A+) RNA-binding protein, involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Gbp2p and Npl3p; Hrb1p 624623 HRB1 855728 HRB1 Saccharomyces cerevisiae Hrb1p NP_014394.2 622917 D 4932 CDS NP_014395.1 6324325 855729 complement(624977..625831) 1 NC_001146.6 S-adenosylmethionine transporter of the mitochondrial inner membrane, member of the mitochondrial carrier family; required for biotin biosynthesis and respiratory growth; Pet8p 625831 PET8 855729 PET8 Saccharomyces cerevisiae Pet8p NP_014395.1 624977 R 4932 CDS NP_014396.1 6324326 855730 complement(626176..627144) 1 NC_001146.6 Rlp7p; Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs 627144 RLP7 855730 RLP7 Saccharomyces cerevisiae Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs NP_014396.1 626176 R 4932 CDS NP_014397.1 6324327 855731 627458..628618 1 NC_001146.6 Endoribonuclease; functions in no-go mRNA decay, protein translation to promote G1 progression and differentiation, required for meiotic cell division; similar to the eukaryotic Pelota; Dom34p 628618 DOM34 855731 DOM34 Saccharomyces cerevisiae Dom34p NP_014397.1 627458 D 4932 CDS NP_014398.1 6324328 855732 complement(629624..631063) 1 NC_001146.6 Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; Cit1p 631063 CIT1 855732 CIT1 Saccharomyces cerevisiae Cit1p NP_014398.1 629624 R 4932 CDS NP_014399.1 6324329 855736 complement(633010..633858) 1 NC_001146.6 Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p; Ato2p 633858 ATO2 855736 ATO2 Saccharomyces cerevisiae Ato2p NP_014399.1 633010 R 4932 CDS NP_014400.1 6324330 855737 complement(634346..635299) 1 NC_001146.6 Rpc34p; RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex 635299 RPC34 855737 RPC34 Saccharomyces cerevisiae RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex NP_014400.1 634346 R 4932 CDS NP_014401.1 6324331 855738 635945..636385 1 NC_001146.6 Ynr004wp; Putative protein of unknown function; haploid disruptant exhibits slow growth rate on glucose-minimal medium at 15 C 636385 855738 YNR004W Saccharomyces cerevisiae Putative protein of unknown function; haploid disruptant exhibits slow growth rate on glucose-minimal medium at 15 C NP_014401.1 635945 D 4932 CDS NP_014403.1 6324332 855739 636988..638856 1 NC_001146.6 Vps27p; Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p) 638856 VPS27 855739 VPS27 Saccharomyces cerevisiae Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p) NP_014403.1 636988 D 4932 CDS NP_014404.1 6324334 855741 complement(639184..640116) 1 NC_001146.6 E2-like enzyme involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt; Atg3p 640116 ATG3 855741 ATG3 Saccharomyces cerevisiae Atg3p NP_014404.1 639184 R 4932 CDS NP_014405.1 6324335 855742 640398..642383 1 NC_001146.6 Lro1p; Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase 642383 LRO1 855742 LRO1 Saccharomyces cerevisiae Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase NP_014405.1 640398 D 4932 CDS NP_014406.1 6324336 855743 642692..643441 1 NC_001146.6 Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase; Nrm1p 643441 NRM1 855743 NRM1 Saccharomyces cerevisiae Nrm1p NP_014406.1 642692 D 4932 CDS NP_014407.1 6324337 855744 643746..644195 1 NC_001146.6 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; component of the Med9/10 module; required for regulation of RNA polymerase II activity; Cse2p 644195 CSE2 855744 CSE2 Saccharomyces cerevisiae Cse2p NP_014407.1 643746 D 4932 CDS NP_014408.1 6324338 855745 complement(644322..646952) 1 NC_001146.6 RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing; Prp2p 646952 PRP2 855745 PRP2 Saccharomyces cerevisiae Prp2p NP_014408.1 644322 R 4932 CDS NP_014409.1 6324339 855746 647434..648939 1 NC_001146.6 Urk1p; Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP 648939 URK1 855746 URK1 Saccharomyces cerevisiae Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP NP_014409.1 647434 D 4932 CDS NP_014410.1 6324340 855747 complement(649030..651714) 1 NC_001146.6 Pho91p; Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth 651714 PHO91 855747 PHO91 Saccharomyces cerevisiae Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth NP_014410.1 649030 R 4932 CDS NP_014411.1 6324341 855748 652467..653105 1 NC_001146.6 Ynr014wp; Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible 653105 855748 YNR014W Saccharomyces cerevisiae Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible NP_014411.1 652467 D 4932 CDS NP_014412.1 6324342 855749 653389..654543 1 NC_001146.6 Smm1p; Dihydrouridine synthase, member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs 654543 SMM1 855749 SMM1 Saccharomyces cerevisiae Dihydrouridine synthase, member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs NP_014412.1 653389 D 4932 CDS NP_014413.1 6324343 855750 complement(654675..661376) 1 NC_001146.6 Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids; Acc1p 661376 ACC1 855750 ACC1 Saccharomyces cerevisiae Acc1p NP_014413.1 654675 R 4932 CDS NP_014414.1 6324344 855751 662915..663583 1 NC_001146.6 Tim23p; Essential protein of the mitochondrial inner membrane, component of the mitochondrial import system 663583 TIM23 855751 TIM23 Saccharomyces cerevisiae Essential protein of the mitochondrial inner membrane, component of the mitochondrial import system NP_014414.1 662915 D 4932 CDS NP_014415.1 6324345 855752 664272..664946 1 NC_001146.6 Putative protein of unknown function; non-tagged protein is detected in purified mitochondria; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media; Aim38p 664946 AIM38 855752 AIM38 Saccharomyces cerevisiae Aim38p NP_014415.1 664272 D 4932 CDS NP_014416.1 6324346 855753 665341..667269 1 NC_001146.6 Are2p; Acyl-CoA:sterol acyltransferase, isozyme of Are1p; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen 667269 ARE2 855753 ARE2 Saccharomyces cerevisiae Acyl-CoA:sterol acyltransferase, isozyme of Are1p; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen NP_014416.1 665341 D 4932 CDS NP_014417.1 6324347 855754 complement(667412..668224) 1 NC_001146.6 Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; Atp23p 668224 ATP23 855754 ATP23 Saccharomyces cerevisiae Atp23p NP_014417.1 667412 R 4932 CDS NP_014418.1 6324348 855755 668379..669593 1 NC_001146.6 Ynr021wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene 669593 855755 YNR021W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene NP_014418.1 668379 D 4932 CDS NP_014419.1 6324349 855756 complement(669776..670195) 1 NC_001146.6 Mrpl50p; Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation 670195 MRPL50 855756 MRPL50 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation NP_014419.1 669776 R 4932 CDS NP_014420.1 6324350 855757 670420..672120 1 NC_001146.6 Snf12p; 73 kDa subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; homolog of Rsc6p subunit of the RSC chromatin remodeling complex; deletion mutants are temperature-sensitive 672120 SNF12 855757 SNF12 Saccharomyces cerevisiae 73 kDa subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; homolog of Rsc6p subunit of the RSC chromatin remodeling complex; deletion mutants are temperature-sensitive NP_014420.1 670420 D 4932 CDS NP_014421.1 6324351 855758 672411..672971 1 NC_001146.6 Ynr024wp; Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus 672971 855758 YNR024W Saccharomyces cerevisiae Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus NP_014421.1 672411 D 4932 CDS NP_014423.1 6324353 855760 complement(673276..674691) 1 NC_001146.6 Sec12p; Guanine nucleotide exchange factor (GEF); glycosylated integral membrane protein of the endoplasmic reticulum, important for the initiation of transport vesicle budding from the endoplasmic reticulum through activation of the GTPase Sar1p 674691 SEC12 855760 SEC12 Saccharomyces cerevisiae Guanine nucleotide exchange factor (GEF); glycosylated integral membrane protein of the endoplasmic reticulum, important for the initiation of transport vesicle budding from the endoplasmic reticulum through activation of the GTPase Sar1p NP_014423.1 673276 R 4932 CDS NP_014424.1 6324354 855761 674925..675878 1 NC_001146.6 Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; Bud17p 675878 BUD17 855761 BUD17 Saccharomyces cerevisiae Bud17p NP_014424.1 674925 D 4932 CDS NP_014425.1 6324355 855762 676179..677105 1 NC_001146.6 Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway; Cpr8p 677105 CPR8 855762 CPR8 Saccharomyces cerevisiae Cpr8p NP_014425.1 676179 D 4932 CDS NP_014426.1 6324356 855763 complement(677201..678490) 1 NC_001146.6 Ynr029cp; Putative protein of unknown function, deletion confers reduced fitness in saline 678490 855763 YNR029C Saccharomyces cerevisiae Putative protein of unknown function, deletion confers reduced fitness in saline NP_014426.1 677201 R 4932 CDS NP_014427.1 6324357 855764 678801..680456 1 NC_001146.6 Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation; Alg12p 680456 ALG12 855764 ALG12 Saccharomyces cerevisiae Alg12p NP_014427.1 678801 D 4932 CDS NP_014428.1 6324358 855765 complement(680696..685435) 1 NC_001146.6 Ssk2p; MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress 685435 SSK2 855765 SSK2 Saccharomyces cerevisiae MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress NP_014428.1 680696 R 4932 CDS NP_014429.1 6324359 855766 686012..687118 1 NC_001146.6 Putative serine/threonine protein phosphatase, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases; Ppg1p 687118 PPG1 855766 PPG1 Saccharomyces cerevisiae Ppg1p NP_014429.1 686012 D 4932 CDS NP_014430.1 6324360 855767 complement(687245..687466) 1 NC_001146.6 Ubiquitin-like protein modifier, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear; Hub1p 687466 HUB1 855767 HUB1 Saccharomyces cerevisiae Hub1p NP_014430.1 687245 R 4932 CDS NP_014431.1 6324361 855768 687637..690000 1 NC_001146.6 Para-aminobenzoate (PABA) synthase, has similarity to Escherichia coli PABA synthase components PabA and PabB; Abz1p 690000 ABZ1 855768 ABZ1 Saccharomyces cerevisiae Abz1p NP_014431.1 687637 D 4932 CDS NP_014432.1 6324362 855769 690323..691288 1 NC_001146.6 Sol1p; Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol2p, Sol3p, and Sol4p 691288 SOL1 855769 SOL1 Saccharomyces cerevisiae Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol2p, Sol3p, and Sol4p NP_014432.1 690323 D 4932 CDS NP_061494.1 9755343 855770 692563..692859 1 NC_001146.6 Ynr034w-ap; Putative protein of unknown function; expression is regulated by Msn2p/Msn4p 692859 855770 YNR034W-A Saccharomyces cerevisiae Putative protein of unknown function; expression is regulated by Msn2p/Msn4p NP_061494.1 692563 D 4932 CDS NP_014433.1 6324363 855771 complement(693021..694049) 1 NC_001146.6 Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin; Arc35p 694049 ARC35 855771 ARC35 Saccharomyces cerevisiae Arc35p NP_014433.1 693021 R 4932 CDS NP_014434.1 6324364 855772 complement(694363..694824) 1 NC_001146.6 Ynr036cp; Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins 694824 855772 YNR036C Saccharomyces cerevisiae Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins NP_014434.1 694363 R 4932 CDS NP_014435.1 6324365 855773 complement(695054..695329) 1 NC_001146.6 Rsm19p; Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein 695329 RSM19 855773 RSM19 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein NP_014435.1 695054 R 4932 CDS NP_014436.1 6324366 855774 695597..697486 1 NC_001146.6 Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family; Dbp6p 697486 DBP6 855774 DBP6 Saccharomyces cerevisiae Dbp6p NP_014436.1 695597 D 4932 CDS NP_014437.1 6324367 855775 complement(697616..699433) 1 NC_001146.6 Zrg17p; Endoplasmic reticulum protein of unknown function, transcription is induced under conditions of zinc deficiency; mutant phenotype suggests a role in uptake of zinc 699433 ZRG17 855775 ZRG17 Saccharomyces cerevisiae Endoplasmic reticulum protein of unknown function, transcription is induced under conditions of zinc deficiency; mutant phenotype suggests a role in uptake of zinc NP_014437.1 697616 R 4932 CDS NP_014438.1 6324368 855776 699692..700462 1 NC_001146.6 Ynr040wp; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 700462 855776 YNR040W Saccharomyces cerevisiae Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_014438.1 699692 D 4932 CDS NP_014439.1 6324370 855778 complement(700543..701661) 1 NC_001146.6 Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis; Coq2p 701661 COQ2 855778 COQ2 Saccharomyces cerevisiae Coq2p NP_014439.1 700543 R 4932 CDS NP_014441.1 6324371 855779 701897..703087 1 NC_001146.6 Mvd1p; Mevalonate pyrophosphate decarboxylase, essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer 703087 MVD1 855779 MVD1 Saccharomyces cerevisiae Mevalonate pyrophosphate decarboxylase, essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer NP_014441.1 701897 D 4932 CDS NP_014442.1 6324372 855780 703701..705878 1 NC_001146.6 Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds; Aga1p 705878 AGA1 855780 AGA1 Saccharomyces cerevisiae Aga1p NP_014442.1 703701 D 4932 CDS NP_014443.1 6324373 855781 706141..707610 1 NC_001146.6 Pet494p; Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane 707610 PET494 855781 PET494 Saccharomyces cerevisiae Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane NP_014443.1 706141 D 4932 CDS NP_014444.1 6324374 855782 707790..708197 1 NC_001146.6 Trm112p; Subunit of an adoMet-dependent tRNA methyltransferase (MTase) complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; putative zinc binding subunit of other MTase-related proteins 708197 TRM112 855782 TRM112 Saccharomyces cerevisiae Subunit of an adoMet-dependent tRNA methyltransferase (MTase) complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; putative zinc binding subunit of other MTase-related proteins NP_014444.1 707790 D 4932 CDS NP_014445.1 6324375 855783 708525..711206 1 NC_001146.6 Ynr047wp; Putative protein kinase that, when overexpressed, interferes with pheromone-induced growth arrest; localizes to the cytoplasm; potential Cdc28p substrate 711206 855783 YNR047W Saccharomyces cerevisiae Putative protein kinase that, when overexpressed, interferes with pheromone-induced growth arrest; localizes to the cytoplasm; potential Cdc28p substrate NP_014445.1 708525 D 4932 CDS NP_014446.1 6324376 855784 711632..712813 1 NC_001146.6 Ynr048wp; Protein proposed to interact with phospholipid translocases, shares similarity to Cdc50p 712813 855784 YNR048W Saccharomyces cerevisiae Protein proposed to interact with phospholipid translocases, shares similarity to Cdc50p NP_014446.1 711632 D 4932 CDS NP_014447.1 6324377 855785 complement(713025..713657) 1 NC_001146.6 Probable component of the secretory vesicle docking complex, acts at a late step in secretion; shows genetic and physical interactions with Sec1p and is enriched in microsomal membrane fractions; required for sporulation; Mso1p 713657 MSO1 855785 MSO1 Saccharomyces cerevisiae Mso1p NP_014447.1 713025 R 4932 CDS NP_014448.1 6324378 855786 complement(714050..715390) 1 NC_001146.6 Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, which is the seventh step in lysine biosynthesis pathway; Lys9p 715390 LYS9 855786 LYS9 Saccharomyces cerevisiae Lys9p NP_014448.1 714050 R 4932 CDS NP_014449.1 6324379 855787 complement(716782..718329) 1 NC_001146.6 Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A; Bre5p 718329 BRE5 855787 BRE5 Saccharomyces cerevisiae Bre5p NP_014449.1 716782 R 4932 CDS NP_014450.1 6324380 855788 complement(719348..720649) 1 NC_001146.6 RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation; Pop2p 720649 POP2 855788 POP2 Saccharomyces cerevisiae Pop2p NP_014450.1 719348 R 4932 CDS NP_014451.1 6324381 855789 complement(join(721122..721772,722304..723113)) 1 NC_001146.6 Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation; Nog2p 723113 NOG2 855789 NOG2 Saccharomyces cerevisiae Nog2p NP_014451.1 721122 R 4932 CDS NP_014452.1 6324382 855790 complement(723357..724307) 1 NC_001146.6 Essential nucleolar protein involved in pre-18S rRNA processing; component of the small subunit (SSU) processome; has sequence similarity to mABT1, a mouse transcription activator; Esf2p 724307 ESF2 855790 ESF2 Saccharomyces cerevisiae Esf2p NP_014452.1 723357 R 4932 CDS NP_014453.1 6324383 855792 complement(728427..730187) 1 NC_001146.6 Putative transporter in the major facilitator superfamily (DHA1 family) of multidrug resistance transporters; mutations in membrane-spanning domains permit cation and histidinol uptake; Hol1p 730187 HOL1 855792 HOL1 Saccharomyces cerevisiae Hol1p NP_014453.1 728427 R 4932 CDS NP_014454.1 6324384 855793 complement(731618..733303) 1 NC_001146.6 Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; Bio5p 733303 BIO5 855793 BIO5 Saccharomyces cerevisiae Bio5p NP_014454.1 731618 R 4932 CDS NP_014455.1 6324385 855794 complement(733356..734069) 1 NC_001146.6 Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels; Bio4p 734069 BIO4 855794 BIO4 Saccharomyces cerevisiae Bio4p NP_014455.1 733356 R 4932 CDS NP_014456.1 6324386 855795 734291..735733 1 NC_001146.6 Bio3p; 7,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis 735733 BIO3 855795 BIO3 Saccharomyces cerevisiae 7,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis NP_014456.1 734291 D 4932 CDS NP_014457.1 6324387 855796 736803..738545 1 NC_001146.6 Putative alpha-1,3-mannosyltransferase, not required for protein O-glycosylation; Mnt4p 738545 MNT4 855796 MNT4 Saccharomyces cerevisiae Mnt4p NP_014457.1 736803 D 4932 CDS NP_014458.1 6324388 855797 739951..742110 1 NC_001146.6 Fre4p; Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels 742110 FRE4 855797 FRE4 Saccharomyces cerevisiae Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels NP_014458.1 739951 D 4932 CDS NP_014459.1 6324389 855798 complement(742881..743540) 1 NC_001146.6 Ynr061cp; Putative protein of unknown function 743540 855798 YNR061C Saccharomyces cerevisiae Putative protein of unknown function NP_014459.1 742881 R 4932 CDS NP_014460.1 6324390 855799 complement(744360..745343) 1 NC_001146.6 Ynr062cp; Putative membrane protein of unknown function 745343 855799 YNR062C Saccharomyces cerevisiae Putative membrane protein of unknown function NP_014460.1 744360 R 4932 CDS NP_014461.1 6324391 855800 746943..748766 1 NC_001146.6 Ynr063wp; Putative zinc-cluster protein of unknown function 748766 855800 YNR063W Saccharomyces cerevisiae Putative zinc-cluster protein of unknown function NP_014461.1 746943 D 4932 CDS NP_014462.1 6324392 855801 complement(749136..750008) 1 NC_001146.6 Ynr064cp; Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides 750008 855801 YNR064C Saccharomyces cerevisiae Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides NP_014462.1 749136 R 4932 CDS NP_014463.1 6324393 855802 complement(750350..753700) 1 NC_001146.6 Ynr065cp; Protein of unknown function; YNR065C is not an essential gene 753700 855802 YNR065C Saccharomyces cerevisiae Protein of unknown function; YNR065C is not an essential gene NP_014463.1 750350 R 4932 CDS NP_014464.1 6324394 855803 complement(753725..755035) 1 NC_001146.6 Ynr066cp; Putative membrane-localized protein of unknown function 755035 855803 YNR066C Saccharomyces cerevisiae Putative membrane-localized protein of unknown function NP_014464.1 753725 R 4932 CDS NP_014465.1 6324395 855804 complement(755746..759099) 1 NC_001146.6 Dse4p; Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother 759099 DSE4 855804 DSE4 Saccharomyces cerevisiae Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother NP_014465.1 755746 R 4932 CDS NP_014466.1 6324396 855805 complement(760067..760885) 1 NC_001146.6 Ynr068cp; Putative protein of unknown function 760885 855805 YNR068C Saccharomyces cerevisiae Putative protein of unknown function NP_014466.1 760067 R 4932 CDS NP_014467.1 6324397 855806 complement(761123..762592) 1 NC_001146.6 Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; Bsc5p 762592 BSC5 855806 BSC5 Saccharomyces cerevisiae Bsc5p NP_014467.1 761123 R 4932 CDS NP_014468.1 6324398 855807 765375..769376 1 NC_001146.6 Ynr070wp; Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 769376 855807 YNR070W Saccharomyces cerevisiae Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_014468.1 765375 D 4932 CDS NP_014469.1 6324399 855808 complement(770440..771468) 1 NC_001146.6 Ynr071cp; Putative protein of unknown function 771468 855808 YNR071C Saccharomyces cerevisiae Putative protein of unknown function NP_014469.1 770440 R 4932 CDS NP_014470.1 6324400 855809 772657..774351 1 NC_001146.6 Hxt17p; Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose 774351 HXT17 855809 HXT17 Saccharomyces cerevisiae Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose NP_014470.1 772657 D 4932 CDS NP_014471.1 6324401 855810 complement(774792..776300) 1 NC_001146.6 Ynr073cp; Putative mannitol dehydrogenase 776300 855810 YNR073C Saccharomyces cerevisiae Putative mannitol dehydrogenase NP_014471.1 774792 R 4932 CDS NP_014472.1 6324402 855811 complement(777602..778738) 1 NC_001146.6 Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase; Aif1p 778738 AIF1 855811 AIF1 Saccharomyces cerevisiae Aif1p NP_014472.1 777602 R 4932 CDS NP_014473.1 6324403 855812 779916..781040 1 NC_001146.6 Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; Cos10p 781040 COS10 855812 COS10 Saccharomyces cerevisiae Cos10p NP_014473.1 779916 D 4932 CDS NP_878159.1 33438871 1466517 complement(781511..781603) 1 NC_001146.6 Ynr075c-ap; Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 781603 1466517 YNR075C-A Saccharomyces cerevisiae Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching NP_878159.1 781511 R 4932 CDS NP_014474.1 6324404 855813 781918..782280 1 NC_001146.6 Pau6p; Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme 782280 PAU6 855813 PAU6 Saccharomyces cerevisiae Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme NP_014474.1 781918 D 4932 CDS NP_878160.1 33438872 1466472 585..740 1 NC_001147.5 Yol166w-ap; Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 740 1466472 YOL166W-A Saccharomyces cerevisiae Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching NP_878160.1 585 D 4932 CDS NP_014477.1 6324408 853999 complement(1647..2078) 1 NC_001147.5 Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; Aad15p 2078 AAD15 853999 AAD15 Saccharomyces cerevisiae Aad15p NP_014477.1 1647 R 4932 CDS NP_878161.1 33438873 1466473 4130..4312 1 NC_001147.5 Yol164w-ap; Putative protein of unknown function; identified by fungal homology and RT-PCR 4312 1466473 YOL164W-A Saccharomyces cerevisiae Putative protein of unknown function; identified by fungal homology and RT-PCR NP_878161.1 4130 D 4932 CDS NP_014478.1 6324409 854000 6175..8115 1 NC_001147.5 Bds1p; Bacterially-derived sulfatase required for use of alkyl- and aryl-sulfates as sulfur sources 8115 BDS1 854000 BDS1 Saccharomyces cerevisiae Bacterially-derived sulfatase required for use of alkyl- and aryl-sulfates as sulfur sources NP_014478.1 6175 D 4932 CDS NP_014479.1 6324410 854001 9596..10105 1 NC_001147.5 Yol163wp; Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family 10105 854001 YOL163W Saccharomyces cerevisiae Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family NP_014479.1 9596 D 4932 CDS NP_014480.1 6324411 854002 10118..10765 1 NC_001147.5 Yol162wp; Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family 10765 854002 YOL162W Saccharomyces cerevisiae Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family NP_014480.1 10118 D 4932 CDS NP_014481.1 6324412 854003 complement(11548..11910) 1 NC_001147.5 Pau20p 11910 PAU20 854003 PAU20 Saccharomyces cerevisiae Pau20p NP_014481.1 11548 R 4932 CDS NP_076909.1 13129187 854005 complement(15232..15504) 1 NC_001147.5 Yol159c-ap; Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species 15504 854005 YOL159C-A Saccharomyces cerevisiae Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species NP_076909.1 15232 R 4932 CDS NP_014483.1 6324414 854006 complement(17280..17795) 1 NC_001147.5 Yol159cp; Soluble protein of unknown function; deletion mutants are viable and have elevated levels of Ty1 retrotransposition and Ty1 cDNA 17795 854006 YOL159C Saccharomyces cerevisiae Soluble protein of unknown function; deletion mutants are viable and have elevated levels of Ty1 retrotransposition and Ty1 cDNA NP_014483.1 17280 R 4932 CDS NP_014484.1 6324415 854007 complement(19490..21310) 1 NC_001147.5 Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment; Enb1p 21310 ENB1 854007 ENB1 Saccharomyces cerevisiae Enb1p NP_014484.1 19490 R 4932 CDS NP_014485.1 6324416 854008 complement(22524..24293) 1 NC_001147.5 Yol157cp; Putative protein of unknown function 24293 854008 YOL157C Saccharomyces cerevisiae Putative protein of unknown function NP_014485.1 22524 R 4932 CDS NP_014486.1 6324417 854009 25272..26975 1 NC_001147.5 Putative hexose transporter that is nearly identical to Hxt9p, has similarity to major facilitator superfamily (MFS) transporters and is involved in pleiotropic drug resistance; Hxt11p 26975 HXT11 854009 HXT11 Saccharomyces cerevisiae Hxt11p NP_014486.1 25272 D 4932 CDS NP_878162.1 33438874 1466474 27083..27217 1 NC_001147.5 Yol155w-ap; Putative protein of unknown function; identified by expression profiling and mass spectrometry 27217 1466474 YOL155W-A Saccharomyces cerevisiae Putative protein of unknown function; identified by expression profiling and mass spectrometry NP_878162.1 27083 D 4932 CDS NP_014487.1 6324418 854010 complement(28702..31605) 1 NC_001147.5 Hpf1p; Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines 31605 HPF1 854010 HPF1 Saccharomyces cerevisiae Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines NP_014487.1 28702 R 4932 CDS NP_014488.1 6324419 854011 34657..35406 1 NC_001147.5 Zps1p; Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH 35406 ZPS1 854011 ZPS1 Saccharomyces cerevisiae Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH NP_014488.1 34657 D 4932 CDS NP_014489.2 84626311 854013 40747..42609 1 NC_001147.5 Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels; Fre7p 42609 FRE7 854013 FRE7 Saccharomyces cerevisiae Fre7p NP_014489.2 40747 D 4932 CDS NP_014490.1 6324421 854014 43693..44721 1 NC_001147.5 NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; Gre2p 44721 GRE2 854014 GRE2 Saccharomyces cerevisiae Gre2p NP_014490.1 43693 D 4932 CDS NP_014492.1 6324423 854016 44937..45632 1 NC_001147.5 Subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; Dcp1p 45632 DCP1 854016 DCP1 Saccharomyces cerevisiae Dcp1p NP_014492.1 44937 D 4932 CDS NP_014493.1 6324424 854017 complement(45759..47573) 1 NC_001147.5 Subunit of the SAGA transcriptional regulatory complex, involved in maintaining the integrity of the complex; Spt20p 47573 SPT20 854017 SPT20 Saccharomyces cerevisiae Spt20p NP_014493.1 45759 R 4932 CDS NP_014494.1 6324425 854018 complement(47932..48642) 1 NC_001147.5 Pex11p; Peroxisomal membrane protein required for peroxisome proliferation and medium-chain fatty acid oxidation, most abundant protein in the peroxisomal membrane, regulated by Adr1p and Pip2p-Oaf1p, promoter contains ORE and UAS1-like elements 48642 PEX11 854018 PEX11 Saccharomyces cerevisiae Peroxisomal membrane protein required for peroxisome proliferation and medium-chain fatty acid oxidation, most abundant protein in the peroxisomal membrane, regulated by Adr1p and Pip2p-Oaf1p, promoter contains ORE and UAS1-like elements NP_014494.1 47932 R 4932 CDS NP_014495.2 37362690 854019 48863..49447 1 NC_001147.5 Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery; Psf3p 49447 PSF3 854019 PSF3 Saccharomyces cerevisiae Psf3p NP_014495.2 48863 D 4932 CDS NP_014496.1 6324427 854020 complement(49554..52787) 1 NC_001147.5 Ctr9p; Component of the Paf1p complex, which is a large complex that binds to and modulates the activity of RNA polymerase II and is required for expression of a subset of genes, including cyclin genes; contains TPR repeats 52787 CTR9 854020 CTR9 Saccharomyces cerevisiae Component of the Paf1p complex, which is a large complex that binds to and modulates the activity of RNA polymerase II and is required for expression of a subset of genes, including cyclin genes; contains TPR repeats NP_014496.1 49554 R 4932 CDS NP_014497.1 6324428 854021 53097..54551 1 NC_001147.5 Nucleolar protein required for 60S ribosomal subunit biogenesis; Nop8p 54551 NOP8 854021 NOP8 Saccharomyces cerevisiae Nop8p NP_014497.1 53097 D 4932 CDS NP_014498.1 6324429 854022 complement(54594..55103) 1 NC_001147.5 Rib4p; Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, also known as DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin 55103 RIB4 854022 RIB4 Saccharomyces cerevisiae Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, also known as DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin NP_014498.1 54594 R 4932 CDS NP_014499.1 6324430 854023 55557..56279 1 NC_001147.5 Rrp40p; Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex 56279 RRP40 854023 RRP40 Saccharomyces cerevisiae Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex NP_014499.1 55557 D 4932 CDS NP_014500.1 6324431 854024 56451..58538 1 NC_001147.5 Putative carboxymethyltransferase, similar to Ppm1p but biochemical activity not yet demonstrated; required for the synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; Ppm2p 58538 PPM2 854024 PPM2 Saccharomyces cerevisiae Ppm2p NP_014500.1 56451 D 4932 CDS NP_014501.1 6324432 854025 58759..60030 1 NC_001147.5 Arg8p; Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine 60030 ARG8 854025 ARG8 Saccharomyces cerevisiae Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine NP_014501.1 58759 D 4932 CDS NP_014502.1 6324433 854026 complement(60383..61024) 1 NC_001147.5 Cytoplasmic mRNA cap binding protein; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with the translation initiation factor eIF4G (Tif4631p or Tif4632p); Cdc33p 61024 CDC33 854026 CDC33 Saccharomyces cerevisiae Cdc33p NP_014502.1 60383 R 4932 CDS NP_014503.1 6324434 853982 complement(61325..65350) 1 NC_001147.5 Yol138cp; Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the vacuole 65350 853982 YOL138C Saccharomyces cerevisiae Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the vacuole NP_014503.1 61325 R 4932 CDS NP_014504.1 6324435 853983 65621..67114 1 NC_001147.5 Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; Bsc6p 67114 BSC6 853983 BSC6 Saccharomyces cerevisiae Bsc6p NP_014504.1 65621 D 4932 CDS NP_014505.1 6324436 853984 complement(67561..68754) 1 NC_001147.5 Pfk27p; 6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A 68754 PFK27 853984 PFK27 Saccharomyces cerevisiae 6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A NP_014505.1 67561 R 4932 CDS NP_014506.1 6324437 853985 complement(69376..70044) 1 NC_001147.5 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; Med7p 70044 MED7 853985 MED7 Saccharomyces cerevisiae Med7p NP_014506.1 69376 R 4932 CDS NP_014508.1 6324438 853986 70325..70690 1 NC_001147.5 RING finger containing subunit of Skp1-Cullin-F-box ubiquitin protein ligases (SCF); required for Gic2p, Far1p, Sic1p and Cln2p degradation; may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF; Hrt1p 70690 HRT1 853986 HRT1 Saccharomyces cerevisiae Hrt1p NP_014508.1 70325 D 4932 CDS NP_014509.1 6324440 853988 71300..72715 1 NC_001147.5 Gas4p; 1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall 72715 GAS4 853988 GAS4 Saccharomyces cerevisiae 1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall NP_014509.1 71300 D 4932 CDS NP_014510.1 6324441 853989 73031..73357 1 NC_001147.5 Yol131wp; Putative protein of unknown function 73357 853989 YOL131W Saccharomyces cerevisiae Putative protein of unknown function NP_014510.1 73031 D 4932 CDS NP_014511.1 6324442 853990 74400..76979 1 NC_001147.5 Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; Alr1p 76979 ALR1 853990 ALR1 Saccharomyces cerevisiae Alr1p NP_014511.1 74400 D 4932 CDS NP_014512.1 6324443 853991 77560..78114 1 NC_001147.5 Vps68p; Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria 78114 VPS68 853991 VPS68 Saccharomyces cerevisiae Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria NP_014512.1 77560 D 4932 CDS NP_014513.1 6324444 853992 complement(78352..79479) 1 NC_001147.5 Ygk3p; Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation 79479 YGK3 853992 YGK3 Saccharomyces cerevisiae Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation NP_014513.1 78352 R 4932 CDS NP_014514.1 6324445 853993 join(80348..80360,80775..81190) 1 NC_001147.5 Rpl25p; Primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit, has similarity to E. coli L23 and rat L23a ribosomal proteins; binds to 26S rRNA via a conserved C-terminal motif 81190 RPL25 853993 RPL25 Saccharomyces cerevisiae Primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit, has similarity to E. coli L23 and rat L23a ribosomal proteins; binds to 26S rRNA via a conserved C-terminal motif NP_014514.1 80348 D 4932 CDS NP_014515.2 116006499 853994 complement(81787..82920) 1 NC_001147.5 Mdh2p; Cytoplasmic malate dehydrogenase, one of the three isozymes that catalyze interconversion of malate and oxaloacetate; involved in gluconeogenesis during growth on ethanol or acetate as carbon source; interacts with Pck1p and Fbp1p 82920 MDH2 853994 MDH2 Saccharomyces cerevisiae Cytoplasmic malate dehydrogenase, one of the three isozymes that catalyze interconversion of malate and oxaloacetate; involved in gluconeogenesis during growth on ethanol or acetate as carbon source; interacts with Pck1p and Fbp1p NP_014515.2 81787 R 4932 CDS NP_014516.1 6324447 853995 83834..85264 1 NC_001147.5 Trm13p; 2'-O-methyltransferase responsible for modification of tRNA at position 4; exhibits no obvious similarity to other known methyltransferases 85264 TRM13 853995 TRM13 Saccharomyces cerevisiae 2'-O-methyltransferase responsible for modification of tRNA at position 4; exhibits no obvious similarity to other known methyltransferases NP_014516.1 83834 D 4932 CDS NP_014517.1 6324448 853996 complement(85456..86757) 1 NC_001147.5 Trm11p; Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain 86757 TRM11 853996 TRM11 Saccharomyces cerevisiae Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain NP_014517.1 85456 R 4932 CDS NP_014518.1 6324449 853997 87844..89448 1 NC_001147.5 Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences; Hrp1p 89448 HRP1 853997 HRP1 Saccharomyces cerevisiae Hrp1p NP_014518.1 87844 D 4932 CDS NP_014519.1 6324450 854027 complement(89692..91419) 1 NC_001147.5 Smf1p; Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins 91419 SMF1 854027 SMF1 Saccharomyces cerevisiae Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins NP_014519.1 89692 R 4932 CDS NP_014520.1 6324451 854028 complement(join(92026..92440,92831..92850)) 1 NC_001147.5 Rps19ap; Protein component of the small (40S) ribosomal subunit, required for assembly and maturation of pre-40 S particles; mutations in human RPS19 are associated with Diamond Blackfan anemia; nearly identical to Rps19Bp 92850 RPS19A 854028 RPS19A Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit, required for assembly and maturation of pre-40 S particles; mutations in human RPS19 are associated with Diamond Blackfan anemia; nearly identical to Rps19Bp NP_014520.1 92026 R 4932 CDS NP_014521.1 6324452 854029 complement(join(93395..93843,94291..94402)) 1 NC_001147.5 Rpl18ap; Protein component of the large (60S) ribosomal subunit, identical to Rpl18Bp and has similarity to rat L18 ribosomal protein; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation 94402 RPL18A 854029 RPL18A Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, identical to Rpl18Bp and has similarity to rat L18 ribosomal protein; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation NP_014521.1 93395 R 4932 CDS NP_014522.1 6324453 854030 complement(94856..96361) 1 NC_001147.5 Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport; Mch4p 96361 MCH4 854030 MCH4 Saccharomyces cerevisiae Mch4p NP_014522.1 94856 R 4932 CDS NP_014524.1 6324455 854032 97551..99488 1 NC_001147.5 Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response; Rri2p 99488 RRI2 854032 RRI2 Saccharomyces cerevisiae Rri2p NP_014524.1 97551 D 4932 CDS NP_014525.1 6324456 854033 99809..100957 1 NC_001147.5 Transcriptional activator involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus; Msn1p 100957 MSN1 854033 MSN1 Saccharomyces cerevisiae Msn1p NP_014525.1 99809 D 4932 CDS NP_014526.1 6324457 854034 101475..103229 1 NC_001147.5 Pap2p; Catalytic subunit of TRAMP (Trf4/Pap2p-Mtr4p-Air1p/2p), a nuclear poly (A) polymerase complex involved in RNA quality control; catalyzes polyadenylation of unmodified tRNAs, and snoRNA and rRNA precursors; disputed role as a DNA polymerase 103229 PAP2 854034 PAP2 Saccharomyces cerevisiae Catalytic subunit of TRAMP (Trf4/Pap2p-Mtr4p-Air1p/2p), a nuclear poly (A) polymerase complex involved in RNA quality control; catalyzes polyadenylation of unmodified tRNAs, and snoRNA and rRNA precursors; disputed role as a DNA polymerase NP_014526.1 101475 D 4932 CDS NP_014527.1 6324458 854035 complement(103317..103925) 1 NC_001147.5 Yol114cp; Putative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination; YOL114C is not an essential gene 103925 854035 YOL114C Saccharomyces cerevisiae Putative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination; YOL114C is not an essential gene NP_014527.1 103317 R 4932 CDS NP_014528.1 6324459 854036 104326..106293 1 NC_001147.5 Skm1p; Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; proposed to be a downstream effector of Cdc42p during polarized growth 106293 SKM1 854036 SKM1 Saccharomyces cerevisiae Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; proposed to be a downstream effector of Cdc42p during polarized growth NP_014528.1 104326 D 4932 CDS NP_014529.1 6324460 854037 106710..108188 1 NC_001147.5 Msb4p; GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization 108188 MSB4 854037 MSB4 Saccharomyces cerevisiae GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization NP_014529.1 106710 D 4932 CDS NP_014530.1 6324461 854038 complement(108258..108896) 1 NC_001147.5 Protein required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes and interacts with YOR164C; contains a ubiquitin-like (UBL) domain; Mdy2p 108896 MDY2 854038 MDY2 Saccharomyces cerevisiae Mdy2p NP_014530.1 108258 R 4932 CDS NP_014531.1 6324462 854039 109176..109889 1 NC_001147.5 Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization; Shr5p 109889 SHR5 854039 SHR5 Saccharomyces cerevisiae Shr5p NP_014531.1 109176 D 4932 CDS NP_014532.1 6324463 854040 110297..110638 1 NC_001147.5 Zeo1p; Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria 110638 ZEO1 854040 ZEO1 Saccharomyces cerevisiae Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria NP_014532.1 110297 D 4932 CDS NP_014533.1 6324464 854042 complement(111431..111886) 1 NC_001147.5 Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain; Ino4p 111886 INO4 854042 INO4 Saccharomyces cerevisiae Ino4p NP_014533.1 111431 R 4932 CDS NP_014534.1 6324465 854043 112102..113130 1 NC_001147.5 Yol107wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein 113130 854043 YOL107W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein NP_014534.1 112102 D 4932 CDS NP_014536.1 6324467 854046 complement(114138..115808) 1 NC_001147.5 Wsc3p; Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity; involved in the response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis 115808 WSC3 854046 WSC3 Saccharomyces cerevisiae Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity; involved in the response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis NP_014536.1 114138 R 4932 CDS NP_014537.1 6324468 854047 complement(116396..117454) 1 NC_001147.5 Ndj1p; Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution (interference), sister chromatid cohesion at meiotic telomeres, and segregation of small chromosomes 117454 NDJ1 854047 NDJ1 Saccharomyces cerevisiae Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution (interference), sister chromatid cohesion at meiotic telomeres, and segregation of small chromosomes NP_014537.1 116396 R 4932 CDS NP_058181.1 7839197 854049 join(118000..119304,119306..123268) 1 NC_001147.5 Yol103w-bp; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 123268 854049 YOL103W-B Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_058181.1 118000 D 4932 CDS NP_058182.1 7839196 854048 118000..119322 1 NC_001147.5 Yol103w-ap; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 119322 854048 YOL103W-A Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_058182.1 118000 D 4932 CDS NP_014538.2 37362691 854050 124001..125830 1 NC_001147.5 Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively; Itr2p 125830 ITR2 854050 ITR2 Saccharomyces cerevisiae Itr2p NP_014538.2 124001 D 4932 CDS NP_014539.1 6324470 854051 complement(125997..126689) 1 NC_001147.5 tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide; Tpt1p 126689 TPT1 854051 TPT1 Saccharomyces cerevisiae Tpt1p NP_014539.1 125997 R 4932 CDS NP_014540.1 6324471 854052 complement(126982..127920) 1 NC_001147.5 Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism; Izh4p 127920 IZH4 854052 IZH4 Saccharomyces cerevisiae Izh4p NP_014540.1 126982 R 4932 CDS NP_014541.1 6324472 854053 129237..132482 1 NC_001147.5 Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p; Pkh2p 132482 PKH2 854053 PKH2 Saccharomyces cerevisiae Pkh2p NP_014541.1 129237 D 4932 CDS NP_014543.1 6324474 854055 complement(132725..135838) 1 NC_001147.5 Yol098cp; Putative metalloprotease 135838 854055 YOL098C Saccharomyces cerevisiae Putative metalloprotease NP_014543.1 132725 R 4932 CDS NP_878163.1 33438875 1466475 136220..136405 1 NC_001147.5 Yol097w-ap; Putative protein of unknown function; identified by expression profiling and mass spectrometry 136405 1466475 YOL097W-A Saccharomyces cerevisiae Putative protein of unknown function; identified by expression profiling and mass spectrometry NP_878163.1 136220 D 4932 CDS NP_014544.1 6324475 854056 complement(136527..137825) 1 NC_001147.5 Wrs1p; Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA 137825 WRS1 854056 WRS1 Saccharomyces cerevisiae Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA NP_014544.1 136527 R 4932 CDS NP_014545.2 37362692 854057 complement(138107..139045) 1 NC_001147.5 O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; Coq3p 139045 COQ3 854057 COQ3 Saccharomyces cerevisiae Coq3p NP_014545.2 138107 R 4932 CDS NP_014546.1 6324477 854058 complement(139227..141347) 1 NC_001147.5 Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD; Hmi1p 141347 HMI1 854058 HMI1 Saccharomyces cerevisiae Hmi1p NP_014546.1 139227 R 4932 CDS NP_014547.1 6324478 854059 complement(141584..142555) 1 NC_001147.5 Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; Rfc4p 142555 RFC4 854059 RFC4 Saccharomyces cerevisiae Rfc4p NP_014547.1 141584 R 4932 CDS NP_014548.1 6324479 854060 142815..143696 1 NC_001147.5 tRNA methyltransferase, methylates the N-1 position of guanosine in tRNAs; Trm10p 143696 TRM10 854060 TRM10 Saccharomyces cerevisiae Trm10p NP_014548.1 142815 D 4932 CDS NP_014549.1 6324480 854061 144204..145130 1 NC_001147.5 Yol092wp; Putative protein of unknown function; predicted to contain six transmembrane domains and is 58% similar to the uncharacterized ORF YBR147W; deletion mutant has no detectable phenotype 145130 854061 YOL092W Saccharomyces cerevisiae Putative protein of unknown function; predicted to contain six transmembrane domains and is 58% similar to the uncharacterized ORF YBR147W; deletion mutant has no detectable phenotype NP_014549.1 144204 D 4932 CDS NP_014550.1 6324481 854062 145334..147163 1 NC_001147.5 Spo21p; Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation 147163 SPO21 854062 SPO21 Saccharomyces cerevisiae Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation NP_014550.1 145334 D 4932 CDS NP_014551.1 6324482 854063 147382..150276 1 NC_001147.5 Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity; Msh2p-Msh6p binds to and hydrolyzes ATP; Msh2p 150276 MSH2 854063 MSH2 Saccharomyces cerevisiae Msh2p NP_014551.1 147382 D 4932 CDS NP_014552.1 6324483 854064 complement(150398..153490) 1 NC_001147.5 Putative transcription factor containing a zinc finger; overexpression increases salt tolerance through increased expression of the ENA1 (Na+/Li+ extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression; Hal9p 153490 HAL9 854064 HAL9 Saccharomyces cerevisiae Hal9p NP_014552.1 150398 R 4932 CDS NP_014553.1 6324484 854065 complement(153912..154745) 1 NC_001147.5 Mpd2p; Member of the protein disulfide isomerase (PDI) family, exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p 154745 MPD2 854065 MPD2 Saccharomyces cerevisiae Member of the protein disulfide isomerase (PDI) family, exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p NP_014553.1 153912 R 4932 CDS NP_014554.1 6324485 854066 complement(155287..158637) 1 NC_001147.5 Yol087cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid 158637 854066 YOL087C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid NP_014554.1 155287 R 4932 CDS NP_076910.1 13129188 854067 159173..159445 1 NC_001147.5 Yol086w-ap; Putative protein of unknown function; identified by homology 159445 854067 YOL086W-A Saccharomyces cerevisiae Putative protein of unknown function; identified by homology NP_076910.1 159173 D 4932 CDS NP_014555.1 6324486 854068 complement(159548..160594) 1 NC_001147.5 Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway; Adh1p 160594 ADH1 854068 ADH1 Saccharomyces cerevisiae Adh1p NP_014555.1 159548 R 4932 CDS NP_014557.1 6324488 854070 162356..165331 1 NC_001147.5 Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; Phm7p 165331 PHM7 854070 PHM7 Saccharomyces cerevisiae Phm7p NP_014557.1 162356 D 4932 CDS NP_014558.1 6324489 854071 165714..166952 1 NC_001147.5 Yol083wp 166952 854071 YOL083W Saccharomyces cerevisiae Yol083wp NP_014558.1 165714 D 4932 CDS NP_014559.1 6324490 854072 168727..169974 1 NC_001147.5 Protein involved in the cytoplasm-to-vacuole targeting pathway and in autophagy, recognizes cargo proteins and delivers them to the preautophagosomal structure for eventual engulfment by the autophagosome and degradation; Atg19p 169974 ATG19 854072 ATG19 Saccharomyces cerevisiae Atg19p NP_014559.1 168727 D 4932 CDS NP_014560.1 6324491 854073 171070..180309 1 NC_001147.5 Ira2p; GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin 180309 IRA2 854073 IRA2 Saccharomyces cerevisiae GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin NP_014560.1 171070 D 4932 CDS NP_014561.1 6324493 854075 complement(180558..181427) 1 NC_001147.5 Rex4p; Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly 181427 REX4 854075 REX4 Saccharomyces cerevisiae Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly NP_014561.1 180558 R 4932 CDS NP_014563.1 6324494 854076 181682..185212 1 NC_001147.5 Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth; Avo1p 185212 AVO1 854076 AVO1 Saccharomyces cerevisiae Avo1p NP_014563.1 181682 D 4932 CDS NP_014564.1 6324495 854077 185438..185644 1 NC_001147.5 Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase; Atp19p 185644 ATP19 854077 ATP19 Saccharomyces cerevisiae Atp19p NP_014564.1 185438 D 4932 CDS NP_014565.1 6324496 854078 complement(185848..186723) 1 NC_001147.5 Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif; Brx1p 186723 BRX1 854078 BRX1 Saccharomyces cerevisiae Brx1p NP_014565.1 185848 R 4932 CDS NP_014566.1 6324497 854079 187024..189414 1 NC_001147.5 Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly; Mdm20p 189414 MDM20 854079 MDM20 Saccharomyces cerevisiae Mdm20p NP_014566.1 187024 D 4932 CDS NP_014567.1 6324498 854080 complement(189658..193542) 1 NC_001147.5 Yol075cp; Putative ABC transporter 193542 854080 YOL075C Saccharomyces cerevisiae Putative ABC transporter NP_014567.1 189658 R 4932 CDS NP_014568.1 6324499 854081 complement(193832..194800) 1 NC_001147.5 Yol073cp; Putative protein of unknown function 194800 854081 YOL073C Saccharomyces cerevisiae Putative protein of unknown function NP_014568.1 193832 R 4932 CDS NP_014569.1 6324500 854082 194970..196337 1 NC_001147.5 Thp1p; Nuclear pore-associated protein, forms a complex with Sac3p that is involved in transcription and in mRNA export from the nucleus; contains a PAM domain implicated in protein-protein binding 196337 THP1 854082 THP1 Saccharomyces cerevisiae Nuclear pore-associated protein, forms a complex with Sac3p that is involved in transcription and in mRNA export from the nucleus; contains a PAM domain implicated in protein-protein binding NP_014569.1 194970 D 4932 CDS NP_014570.1 6324501 854083 196507..196995 1 NC_001147.5 Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; Emi5p 196995 EMI5 854083 EMI5 Saccharomyces cerevisiae Emi5p NP_014570.1 196507 D 4932 CDS NP_014571.1 6324502 854084 complement(197220..198725) 1 NC_001147.5 Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, and bud neck; potential Cdc28p substrate; Nba1p 198725 NBA1 854084 NBA1 Saccharomyces cerevisiae Nba1p NP_014571.1 197220 R 4932 CDS NP_014572.1 6324503 854085 198942..200297 1 NC_001147.5 Nuf2p; Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering 200297 NUF2 854085 NUF2 Saccharomyces cerevisiae Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering NP_014572.1 198942 D 4932 CDS NP_014573.1 6324504 854086 complement(200368..201879) 1 NC_001147.5 NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and mitotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance; Hst1p 201879 HST1 854086 HST1 Saccharomyces cerevisiae Hst1p NP_014573.1 200368 R 4932 CDS NP_014574.1 6324505 854087 complement(201985..202518) 1 NC_001147.5 Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus; Rtg1p 202518 RTG1 854087 RTG1 Saccharomyces cerevisiae Rtg1p NP_014574.1 201985 R 4932 CDS NP_014575.1 6324506 854088 complement(202696..204471) 1 NC_001147.5 Rib2p; DRAP deaminase, catalyzes the third step of the riboflavin biosynthesis pathway; cytoplasmic tRNA pseudouridine synthase involved in pseudouridylation of cytoplasmic tRNAs at position 32 204471 RIB2 854088 RIB2 Saccharomyces cerevisiae DRAP deaminase, catalyzes the third step of the riboflavin biosynthesis pathway; cytoplasmic tRNA pseudouridine synthase involved in pseudouridylation of cytoplasmic tRNAs at position 32 NP_014575.1 202696 R 4932 CDS NP_014576.1 6324507 854089 complement(204731..205885) 1 NC_001147.5 Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins; Inp54p 205885 INP54 854089 INP54 Saccharomyces cerevisiae Inp54p NP_014576.1 204731 R 4932 CDS NP_014577.1 6324508 854090 complement(206103..207176) 1 NC_001147.5 Met22p; Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway 207176 MET22 854090 MET22 Saccharomyces cerevisiae Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway NP_014577.1 206103 R 4932 CDS NP_014578.1 6324509 854091 complement(207392..210265) 1 NC_001147.5 Protein involved in transcriptional regulation of RNR2 and RNR3; expression of the gene is induced by DNA damage and null mutations confer increased resistance to hydroxyurea; N-terminal region has a leucine repeat and a WD40 repeat; Crt10p 210265 CRT10 854091 CRT10 Saccharomyces cerevisiae Crt10p NP_014578.1 207392 R 4932 CDS NP_014579.1 6324510 854092 complement(210520..211995) 1 NC_001147.5 Mu2-like subunit of the clathrin associated protein complex (AP-2); involved in vesicle transport; Apm4p 211995 APM4 854092 APM4 Saccharomyces cerevisiae Apm4p NP_014579.1 210520 R 4932 CDS NP_014580.1 6324511 854093 212244..213734 1 NC_001147.5 Prs5p; 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involved in nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes 213734 PRS5 854093 PRS5 Saccharomyces cerevisiae 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involved in nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes NP_014580.1 212244 D 4932 CDS NP_014581.1 6324512 854094 complement(214017..216137) 1 NC_001147.5 Protein required for normal mitochondrial morphology, has similarity to hemolysins; Mam3p 216137 MAM3 854094 MAM3 Saccharomyces cerevisiae Mam3p NP_014581.1 214017 R 4932 CDS NP_014582.1 6324513 854095 217126..218448 1 NC_001147.5 NAD-dependent glycerol 3-phosphate dehydrogenase, homolog of Gpd1p, expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria; Gpd2p 218448 GPD2 854095 GPD2 Saccharomyces cerevisiae Gpd2p NP_014582.1 217126 D 4932 CDS NP_014583.1 6324514 854096 219210..220472 1 NC_001147.5 Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate; Arg1p 220472 ARG1 854096 ARG1 Saccharomyces cerevisiae Arg1p NP_014583.1 219210 D 4932 CDS NP_014584.1 6324515 854097 220766..222901 1 NC_001147.5 Yol057wp; Putative metalloprotease 222901 854097 YOL057W Saccharomyces cerevisiae Putative metalloprotease NP_014584.1 220766 D 4932 CDS NP_014585.1 6324516 854098 223267..224178 1 NC_001147.5 Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event; Gpm3p 224178 GPM3 854098 GPM3 Saccharomyces cerevisiae Gpm3p NP_014585.1 223267 D 4932 CDS NP_014586.1 6324517 854099 complement(224419..226074) 1 NC_001147.5 Thi20p; Multifunctional protein with both hydroxymethylpyrimidine kinase and thiaminase activities; involved in thiamine biosynthesis and also in thiamine degradation; member of a gene family with THI21 and THI22; functionally redundant with Thi21p 226074 THI20 854099 THI20 Saccharomyces cerevisiae Multifunctional protein with both hydroxymethylpyrimidine kinase and thiaminase activities; involved in thiamine biosynthesis and also in thiamine degradation; member of a gene family with THI21 and THI22; functionally redundant with Thi21p NP_014586.1 224419 R 4932 CDS NP_014587.1 6324518 854102 228613..229833 1 NC_001147.5 Psh1p; Nuclear protein, putative RNA polymerase II elongation factor; isolated as Pob3p/Spt16p-binding protein 229833 PSH1 854102 PSH1 Saccharomyces cerevisiae Nuclear protein, putative RNA polymerase II elongation factor; isolated as Pob3p/Spt16p-binding protein NP_014587.1 228613 D 4932 CDS NP_014588.1 6324519 854103 230084..231271 1 NC_001147.5 Putative protein of unknown function; YOL053W is not an essential gene; null mutant displays decreased frequency of mitochondrial genome loss (petite formation); Aim39p 231271 AIM39 854103 AIM39 Saccharomyces cerevisiae Aim39p NP_014588.1 230084 D 4932 CDS NP_014589.1 6324520 854104 complement(231569..231754) 1 NC_001147.5 Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; Ddr2p 231754 DDR2 854104 DDR2 Saccharomyces cerevisiae Ddr2p NP_014589.1 231569 R 4932 CDS NP_014590.1 6324521 854105 complement(232445..233635) 1 NC_001147.5 Spe2p; S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically 233635 SPE2 854105 SPE2 Saccharomyces cerevisiae S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically NP_014590.1 232445 R 4932 CDS NP_014591.1 6324522 854106 234939..238184 1 NC_001147.5 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; Gal11p 238184 GAL11 854106 GAL11 Saccharomyces cerevisiae Gal11p NP_014591.1 234939 D 4932 CDS NP_014593.1 6324524 854108 238618..240093 1 NC_001147.5 Gsh2p; Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock 240093 GSH2 854108 GSH2 Saccharomyces cerevisiae Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock NP_014593.1 238618 D 4932 CDS NP_014594.2 37362693 854109 complement(join(240203..240946,241025..241309)) 1 NC_001147.5 Yol048cp; Putative protein of unknown function 241309 854109 YOL048C Saccharomyces cerevisiae Putative protein of unknown function NP_014594.2 240203 R 4932 CDS NP_014595.2 9755359 854110 complement(join(241613..242440,242504..242746)) 1 NC_001147.5 Yol047cp; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 242746 854110 YOL047C Saccharomyces cerevisiae Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern NP_014595.2 241613 R 4932 CDS NP_014597.1 6324527 854111 243496..246801 1 NC_001147.5 Psk2p; One of two (see also PSK1) PAS domain containing S/T protein kinases; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation) 246801 PSK2 854111 PSK2 Saccharomyces cerevisiae One of two (see also PSK1) PAS domain containing S/T protein kinases; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation) NP_014597.1 243496 D 4932 CDS NP_014598.1 6324529 854113 247149..248300 1 NC_001147.5 Phosphorylated tail-anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis, cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol, overexpression results in impaired peroxisome assembly; Pex15p 248300 PEX15 854113 PEX15 Saccharomyces cerevisiae Pex15p NP_014598.1 247149 D 4932 CDS NP_014599.1 6324530 854114 complement(248391..249533) 1 NC_001147.5 Ntg2p; DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair, localizes to the nucleus 249533 NTG2 854114 NTG2 Saccharomyces cerevisiae DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair, localizes to the nucleus NP_014599.1 248391 R 4932 CDS NP_014600.1 6324531 854115 249824..250915 1 NC_001147.5 Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Ngl1p 250915 NGL1 854115 NGL1 Saccharomyces cerevisiae Ngl1p NP_014600.1 249824 D 4932 CDS NP_014601.1 6324532 854116 complement(251266..252645) 1 NC_001147.5 Nucleolar protein, required for pre-25S rRNA processing; contains an RNA recognition motif (RRM) and has similarity to Nop13p, Nsr1p, and putative orthologs in Drosophila and S. pombe; Nop12p 252645 NOP12 854116 NOP12 Saccharomyces cerevisiae Nop12p NP_014601.1 251266 R 4932 CDS NP_014602.1 6324533 854117 complement(253148..253576) 1 NC_001147.5 Rps15p; Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S19 and rat S15 ribosomal proteins 253576 RPS15 854117 RPS15 Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S19 and rat S15 ribosomal proteins NP_014602.1 253148 R 4932 CDS NP_014603.1 6324534 854118 254296..254616 1 NC_001147.5 Rpp2ap; Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm 254616 RPP2A 854118 RPP2A Saccharomyces cerevisiae Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm NP_014603.1 254296 D 4932 CDS NP_878164.1 33438876 1466476 complement(254925..255020) 1 NC_001147.5 Yol038c-ap; Putative protein of unknown function; identified by SAGE analysis 255020 1466476 YOL038C-A Saccharomyces cerevisiae Putative protein of unknown function; identified by SAGE analysis NP_878164.1 254925 R 4932 CDS NP_014604.1 6324535 854119 255336..256100 1 NC_001147.5 Pre6p; 20S proteasome alpha-type subunit; green fluorescent protein (GFP)-fusion protein relocates from the cytosol to the mitochondrial outer surface upon oxidative stress 256100 PRE6 854119 PRE6 Saccharomyces cerevisiae 20S proteasome alpha-type subunit; green fluorescent protein (GFP)-fusion protein relocates from the cytosol to the mitochondrial outer surface upon oxidative stress NP_014604.1 255336 D 4932 CDS NP_014606.1 6324536 854120 256744..259029 1 NC_001147.5 Yol036wp; Protein of unknown function; potential Cdc28p substrate 259029 854120 YOL036W Saccharomyces cerevisiae Protein of unknown function; potential Cdc28p substrate NP_014606.1 256744 D 4932 CDS NP_014608.1 6324539 854123 259924..263205 1 NC_001147.5 Structural maintenance of chromosomes (SMC) protein; essential subunit of the Mms21-Smc5-Smc6 complex; required for growth and DNA repair; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair; Smc5p 263205 SMC5 854123 SMC5 Saccharomyces cerevisiae Smc5p NP_014608.1 259924 D 4932 CDS NP_014609.1 6324540 854124 263476..265086 1 NC_001147.5 Mse1p; Mitochondrial glutamyl-tRNA synthetase, encoded by a nuclear gene 265086 MSE1 854124 MSE1 Saccharomyces cerevisiae Mitochondrial glutamyl-tRNA synthetase, encoded by a nuclear gene NP_014609.1 263476 D 4932 CDS NP_014610.1 6324541 854125 265430..266170 1 NC_001147.5 Protein with a possible role in phospholipid biosynthesis, based on inositol-excreting phenotype of the null mutant and its suppression by exogenous choline; Opi10p 266170 OPI10 854125 OPI10 Saccharomyces cerevisiae Opi10p NP_014610.1 265430 D 4932 CDS NP_014611.1 6324542 854126 complement(266265..267530) 1 NC_001147.5 Sil1p; Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein 267530 SIL1 854126 SIL1 Saccharomyces cerevisiae Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein NP_014611.1 266265 R 4932 CDS NP_014612.1 6324543 854127 268188..269642 1 NC_001147.5 Gas5p; 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall 269642 GAS5 854127 GAS5 Saccharomyces cerevisiae 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall NP_014612.1 268188 D 4932 CDS NP_014613.1 6324544 854128 complement(269816..270421) 1 NC_001147.5 Yol029cp; Putative protein of unknown function; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens 270421 854128 YOL029C Saccharomyces cerevisiae Putative protein of unknown function; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens NP_014613.1 269816 R 4932 CDS NP_014614.1 6324545 854129 complement(270634..271371) 1 NC_001147.5 Yap7p; Putative basic leucine zipper (bZIP) transcription factor 271371 YAP7 854129 YAP7 Saccharomyces cerevisiae Putative basic leucine zipper (bZIP) transcription factor NP_014614.1 270634 R 4932 CDS NP_014615.1 6324546 854130 complement(272004..273725) 1 NC_001147.5 Mitochondrial inner membrane protein, involved in membrane integration of a subset of mitochondrial proteins; required for K+/H+ exchange; associates with mitochondrial ribosomes; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome; Mdm38p 273725 MDM38 854130 MDM38 Saccharomyces cerevisiae Mdm38p NP_014615.1 272004 R 4932 CDS NP_014616.1 6324547 854131 complement(274013..274354) 1 NC_001147.5 Mitochondrial outer membrane protein, required for assembly of the translocase of the outer membrane (TOM) complex and thereby for mitochondrial protein import; N terminus is exposed to the cytosol: transmembrane segment is highly conserved; Mim1p 274354 MIM1 854131 MIM1 Saccharomyces cerevisiae Mim1p NP_014616.1 274013 R 4932 CDS NP_014617.1 6324548 854133 274958..276940 1 NC_001147.5 Protein involved in determination of longevity; LAG2 gene is preferentially expressed in young cells; overexpression extends the mean and maximum life span of cells; Lag2p 276940 LAG2 854133 LAG2 Saccharomyces cerevisiae Lag2p NP_014617.1 274958 D 4932 CDS NP_014618.1 6324549 854134 277087..277605 1 NC_001147.5 Yol024wp; Putative protein of unknown function, predicted to have thiol-disulfide oxidoreductase active site 277605 854134 YOL024W Saccharomyces cerevisiae Putative protein of unknown function, predicted to have thiol-disulfide oxidoreductase active site NP_014618.1 277087 D 4932 CDS NP_014619.1 6324550 854135 278057..280087 1 NC_001147.5 Mitochondrial translation initiation factor 2; Ifm1p 280087 IFM1 854135 IFM1 Saccharomyces cerevisiae Ifm1p NP_014619.1 278057 D 4932 CDS NP_014620.1 6324551 854136 complement(280273..281499) 1 NC_001147.5 Tsr4p; Cytoplasmic protein of unknown function; essential gene in S288C, and non-essential with reduced growth rate in CEN.PK2; Null mutant accumulates 20S pre-rRNA 281499 TSR4 854136 TSR4 Saccharomyces cerevisiae Cytoplasmic protein of unknown function; essential gene in S288C, and non-essential with reduced growth rate in CEN.PK2; Null mutant accumulates 20S pre-rRNA NP_014620.1 280273 R 4932 CDS NP_014621.1 6324552 854138 complement(282422..285427) 1 NC_001147.5 Dis3p; Catalytic component of the exosome, involved in RNA processing and degradation; binds Gsp1p/Ran and enhances the GEF activity of Srm1p; implicated in mitotic control; homologous to the E. coli RNase R of the RNase II family 285427 DIS3 854138 DIS3 Saccharomyces cerevisiae Catalytic component of the exosome, involved in RNA processing and degradation; binds Gsp1p/Ran and enhances the GEF activity of Srm1p; implicated in mitotic control; homologous to the E. coli RNase R of the RNase II family NP_014621.1 282422 R 4932 CDS NP_014622.1 6324553 854139 286173..287951 1 NC_001147.5 Tat2p; High affinity tryptophan and tyrosine permease, overexpression confers FK506 and FTY720 resistance 287951 TAT2 854139 TAT2 Saccharomyces cerevisiae High affinity tryptophan and tyrosine permease, overexpression confers FK506 and FTY720 resistance NP_014622.1 286173 D 4932 CDS NP_878165.1 33438877 1466477 288421..288573 1 NC_001147.5 Yol019w-ap; Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 288573 1466477 YOL019W-A Saccharomyces cerevisiae Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching NP_878165.1 288421 D 4932 CDS NP_014623.1 6324554 854141 288899..290554 1 NC_001147.5 Yol019wp; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole 290554 854141 YOL019W Saccharomyces cerevisiae Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole NP_014623.1 288899 D 4932 CDS NP_014624.1 6324555 854142 complement(290882..292075) 1 NC_001147.5 Tlg2p; Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation 292075 TLG2 854142 TLG2 Saccharomyces cerevisiae Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation NP_014624.1 290882 R 4932 CDS NP_014625.1 6324556 854143 292530..294674 1 NC_001147.5 Protein involved in telomeric and mating-type locus silencing, interacts with Sir2p and also interacts with the Gal11p, which is a component of the RNA pol II mediator complex; Esc8p 294674 ESC8 854143 ESC8 Saccharomyces cerevisiae Esc8p NP_014625.1 292530 D 4932 CDS NP_014626.1 6324557 854144 complement(294778..296121) 1 NC_001147.5 Cmk2p; Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk1p and mammalian Cam Kinase II 296121 CMK2 854144 CMK2 Saccharomyces cerevisiae Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk1p and mammalian Cam Kinase II NP_014626.1 294778 R 4932 CDS NP_014627.1 6324558 854145 297079..298839 1 NC_001147.5 hypothetical protein; null mutant displays increased levels of spontaneous Rad52 foci; Irc10p 298839 IRC10 854145 IRC10 Saccharomyces cerevisiae Irc10p NP_014627.1 297079 D 4932 CDS NP_014628.1 6324559 854146 299694..300068 1 NC_001147.5 Yol014wp; Putative protein of unknown function 300068 854146 YOL014W Saccharomyces cerevisiae Putative protein of unknown function NP_014628.1 299694 D 4932 CDS NP_878166.1 33438878 1466478 301048..301239 1 NC_001147.5 Yol013w-ap; Putative protein of unknown function; identified by SAGE 301239 1466478 YOL013W-A Saccharomyces cerevisiae Putative protein of unknown function; identified by SAGE NP_878166.1 301048 D 4932 CDS NP_014630.1 6324561 854149 complement(301381..303036) 1 NC_001147.5 Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; Hrd1p 303036 HRD1 854149 HRD1 Saccharomyces cerevisiae Hrd1p NP_014630.1 301381 R 4932 CDS NP_014631.1 6324562 854150 complement(303580..303984) 1 NC_001147.5 Htz1p; Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin 303984 HTZ1 854150 HTZ1 Saccharomyces cerevisiae Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin NP_014631.1 303580 R 4932 CDS NP_014632.1 6324563 854151 305350..307410 1 NC_001147.5 Plb3p; Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro 307410 PLB3 854151 PLB3 Saccharomyces cerevisiae Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro NP_014632.1 305350 D 4932 CDS NP_014633.1 6324564 854152 307939..309042 1 NC_001147.5 Rcl1p; RNA terminal phosphate cyclase-like protein involved in rRNA processing at sites A0, A1, and A2; does not possess detectable RNA cyclase activity 309042 RCL1 854152 RCL1 Saccharomyces cerevisiae RNA terminal phosphate cyclase-like protein involved in rRNA processing at sites A0, A1, and A2; does not possess detectable RNA cyclase activity NP_014633.1 307939 D 4932 CDS NP_014634.1 6324565 854153 complement(309325..310140) 1 NC_001147.5 Mitochondrial outer membrane protein, required for transmission of mitochondria to daughter cells; component of the Mdm10-Mdm12-Mmm1 complex involved in import and assembly of outer membrane beta-barrel proteins; Mdm12p 310140 MDM12 854153 MDM12 Saccharomyces cerevisiae Mdm12p NP_014634.1 309325 R 4932 CDS NP_014635.1 6324566 854154 310313..310936 1 NC_001147.5 Coq10p; Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q6 to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes 310936 COQ10 854154 COQ10 Saccharomyces cerevisiae Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q6 to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes NP_014635.1 310313 D 4932 CDS NP_014636.1 6324567 854155 complement(311343..312368) 1 NC_001147.5 Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene; Csi2p 312368 CSI2 854155 CSI2 Saccharomyces cerevisiae Csi2p NP_014636.1 311343 R 4932 CDS NP_014637.1 6324568 854156 complement(313079..315388) 1 NC_001147.5 Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination; Top1p 315388 TOP1 854156 TOP1 Saccharomyces cerevisiae Top1p NP_014637.1 313079 R 4932 CDS NP_014638.1 6324569 854157 complement(315814..316176) 1 NC_001147.5 Rpb11p; RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit 316176 RPB11 854157 RPB11 Saccharomyces cerevisiae RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit NP_014638.1 315814 R 4932 CDS NP_014639.1 6324570 854158 316939..321549 1 NC_001147.5 Sin3p; Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity 321549 SIN3 854158 SIN3 Saccharomyces cerevisiae Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity NP_014639.1 316939 D 4932 CDS NP_014640.1 6324571 854159 complement(321859..322995) 1 NC_001147.5 Pfa4p; Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases 322995 PFA4 854159 PFA4 Saccharomyces cerevisiae Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases NP_014640.1 321859 R 4932 CDS NP_014641.2 27808716 854160 complement(323412..324365) 1 NC_001147.5 Plasma membrane protein involved in zinc metabolism and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc; Izh2p 324365 IZH2 854160 IZH2 Saccharomyces cerevisiae Izh2p NP_014641.2 323412 R 4932 CDS NP_014642.1 6324573 854161 325250..326131 1 NC_001147.5 Pho80p; Cyclin, negatively regulates phosphate metabolism; Pho80p-Pho85p (cyclin-CDK complex) phosphorylates Pho4p and Swi5p; deletion of PHO80 leads to aminoglycoside supersensitivity; truncated form of PHO80 affects vacuole inheritance 326131 PHO80 854161 PHO80 Saccharomyces cerevisiae Cyclin, negatively regulates phosphate metabolism; Pho80p-Pho85p (cyclin-CDK complex) phosphorylates Pho4p and Swi5p; deletion of PHO80 leads to aminoglycoside supersensitivity; truncated form of PHO80 affects vacuole inheritance NP_014642.1 325250 D 4932 CDS NP_014643.1 6324574 854162 326833..329034 1 NC_001147.5 Rrp6p; Exonuclease component of the nuclear exosome; contributes to the quality-control system that retains and degrades aberrant mRNAs in the nucleus 329034 RRP6 854162 RRP6 Saccharomyces cerevisiae Exonuclease component of the nuclear exosome; contributes to the quality-control system that retains and degrades aberrant mRNAs in the nucleus NP_014643.1 326833 D 4932 CDS NP_014644.1 6324575 854163 329418..331052 1 NC_001147.5 Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease; Alg6p 331052 ALG6 854163 ALG6 Saccharomyces cerevisiae Alg6p NP_014644.1 329418 D 4932 CDS NP_014645.1 6324576 854164 331456..332892 1 NC_001147.5 Ysp3p; Putative precursor to the subtilisin-like protease III 332892 YSP3 854164 YSP3 Saccharomyces cerevisiae Putative precursor to the subtilisin-like protease III NP_014645.1 331456 D 4932 CDS NP_014646.1 6324577 854165 333593..334357 1 NC_001147.5 Utp23p; Essential nucleolar protein that is a component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function 334357 UTP23 854165 UTP23 Saccharomyces cerevisiae Essential nucleolar protein that is a component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function NP_014646.1 333593 D 4932 CDS NP_014647.1 6324578 854166 complement(334510..337344) 1 NC_001147.5 Dnl4p; DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth 337344 DNL4 854166 DNL4 Saccharomyces cerevisiae DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth NP_014647.1 334510 R 4932 CDS NP_014648.1 6324579 854167 complement(337681..338622) 1 NC_001147.5 Tsr3p; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; Null mutant accumulates 20S pre-rRNA 338622 TSR3 854167 TSR3 Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; Null mutant accumulates 20S pre-rRNA NP_014648.1 337681 R 4932 CDS NP_014649.1 6324580 854168 complement(338939..339979) 1 NC_001147.5 Sgt2p; Glutamine-rich cytoplasmic protein of unknown function; contains tetratricopeptide (TPR) repeats, which often mediate protein-protein interactions; has similarity to human SGT, which is a cochaperone that negatively regulates Hsp70 339979 SGT2 854168 SGT2 Saccharomyces cerevisiae Glutamine-rich cytoplasmic protein of unknown function; contains tetratricopeptide (TPR) repeats, which often mediate protein-protein interactions; has similarity to human SGT, which is a cochaperone that negatively regulates Hsp70 NP_014649.1 338939 R 4932 CDS NP_014650.1 6324581 854170 complement(341279..342415) 1 NC_001147.5 Slg1p; Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway involved in maintenance of cell wall integrity; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response 342415 SLG1 854170 SLG1 Saccharomyces cerevisiae Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway involved in maintenance of cell wall integrity; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response NP_014650.1 341279 R 4932 CDS NP_014651.1 6324582 854171 complement(342858..343082) 1 NC_001147.5 Yor008c-ap; Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres 343082 854171 YOR008C-A Saccharomyces cerevisiae Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres NP_014651.1 342858 R 4932 CDS NP_014652.1 6324583 854173 344335..345798 1 NC_001147.5 Tir4p; Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock 345798 TIR4 854173 TIR4 Saccharomyces cerevisiae Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock NP_014652.1 344335 D 4932 CDS NP_014653.1 6324584 854174 complement(346195..346950) 1 NC_001147.5 Tir2p; Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis 346950 TIR2 854174 TIR2 Saccharomyces cerevisiae Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis NP_014653.1 346195 R 4932 CDS NP_014654.1 6324585 854175 349679..353863 1 NC_001147.5 Transporter of the ATP-binding cassette family, involved in uptake of sterols and anaerobic growth; Aus1p 353863 AUS1 854175 AUS1 Saccharomyces cerevisiae Aus1p NP_014654.1 349679 D 4932 CDS NP_878167.1 33438879 1466479 355652..355858 1 NC_001147.5 Yor011w-ap; Putative protein of unknown function 355858 1466479 YOR011W-A Saccharomyces cerevisiae Putative protein of unknown function NP_878167.1 355652 D 4932 CDS NP_014655.1 6324586 854177 356543..356956 1 NC_001147.5 Yor012wp; Putative protein of unknown function 356956 854177 YOR012W Saccharomyces cerevisiae Putative protein of unknown function NP_014655.1 356543 D 4932 CDS NP_014657.1 6324588 854179 357674..359947 1 NC_001147.5 Rts1p; B-type regulatory subunit of protein phosphatase 2A (PP2A); homolog of the mammalian B' subunit of PP2A 359947 RTS1 854179 RTS1 Saccharomyces cerevisiae B-type regulatory subunit of protein phosphatase 2A (PP2A); homolog of the mammalian B' subunit of PP2A NP_014657.1 357674 D 4932 CDS NP_014659.1 6324590 854181 complement(360461..361084) 1 NC_001147.5 Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport; Erp4p 361084 ERP4 854181 ERP4 Saccharomyces cerevisiae Erp4p NP_014659.1 360461 R 4932 CDS NP_014660.1 6324591 854182 361412..363814 1 NC_001147.5 Protein with a role in mitochondrial RNA stability and/or processing, located in the mitochondrial membrane; Pet127p 363814 PET127 854182 PET127 Saccharomyces cerevisiae Pet127p NP_014660.1 361412 D 4932 CDS NP_014661.1 6324592 854183 364369..366882 1 NC_001147.5 Rod1p; Membrane protein; overexpression confers resistance to the GST substrate o-dinitrobenzene as well as to zinc and calcium; contains 2 PY motifs, which are required for Rod1p interaction with Rsp5p, a hect-type ubiquitin ligase 366882 ROD1 854183 ROD1 Saccharomyces cerevisiae Membrane protein; overexpression confers resistance to the GST substrate o-dinitrobenzene as well as to zinc and calcium; contains 2 PY motifs, which are required for Rod1p interaction with Rsp5p, a hect-type ubiquitin ligase NP_014661.1 364369 D 4932 CDS NP_014662.1 6324593 854184 368127..370319 1 NC_001147.5 Yor019wp; Protein of unknown function that may interact with ribosomes, based on co-purification experiments 370319 854184 YOR019W Saccharomyces cerevisiae Protein of unknown function that may interact with ribosomes, based on co-purification experiments NP_014662.1 368127 D 4932 CDS NP_014663.1 6324594 854185 complement(370524..370844) 1 NC_001147.5 Mitochondrial matrix co-chaperonin that inhibits the ATPase activity of Hsp60p, a mitochondrial chaperonin; involved in protein folding and sorting in the mitochondria; 10 kD heat shock protein with similarity to E. coli groES; Hsp10p 370844 HSP10 854185 HSP10 Saccharomyces cerevisiae Hsp10p NP_014663.1 370524 R 4932 CDS NP_878168.1 33438880 1466480 371685..371957 1 NC_001147.5 Yor020w-ap; Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 371957 1466480 YOR020W-A Saccharomyces cerevisiae Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_878168.1 371685 D 4932 CDS NP_014664.1 6324595 854186 complement(372798..373439) 1 NC_001147.5 Yor021cp; Putative protein of unknown function; YOR021C is not an essential gene 373439 854186 YOR021C Saccharomyces cerevisiae Putative protein of unknown function; YOR021C is not an essential gene NP_014664.1 372798 R 4932 CDS NP_014665.1 6324596 854187 complement(373710..375857) 1 NC_001147.5 Yor022cp; Protein with similarity to bovine phospholipase A1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 375857 854187 YOR022C Saccharomyces cerevisiae Protein with similarity to bovine phospholipase A1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_014665.1 373710 R 4932 CDS NP_014666.1 6324597 854188 complement(376012..377712) 1 NC_001147.5 Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex; Ahc1p 377712 AHC1 854188 AHC1 Saccharomyces cerevisiae Ahc1p NP_014666.1 376012 R 4932 CDS NP_014668.1 6324599 854190 378219..379562 1 NC_001147.5 Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism; Hst3p 379562 HST3 854190 HST3 Saccharomyces cerevisiae Hst3p NP_014668.1 378219 D 4932 CDS NP_014669.1 6324600 854191 379781..380806 1 NC_001147.5 Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p; Bub3p 380806 BUB3 854191 BUB3 Saccharomyces cerevisiae Bub3p NP_014669.1 379781 D 4932 CDS NP_014670.1 6324601 854192 381053..382822 1 NC_001147.5 Sti1p; Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones; activates the ATPase activity of Ssa1p; homolog of mammalian Hop protein 382822 STI1 854192 STI1 Saccharomyces cerevisiae Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones; activates the ATPase activity of Ssa1p; homolog of mammalian Hop protein NP_014670.1 381053 D 4932 CDS NP_014671.1 6324602 854193 complement(383533..384420) 1 NC_001147.5 Cin5p; Basic leucine zipper transcriptional factor of the yAP-1 family that mediates pleiotropic drug resistance and salt tolerance; localizes constitutively to the nucleus 384420 CIN5 854193 CIN5 Saccharomyces cerevisiae Basic leucine zipper transcriptional factor of the yAP-1 family that mediates pleiotropic drug resistance and salt tolerance; localizes constitutively to the nucleus NP_014671.1 383533 R 4932 CDS NP_014673.1 6324604 854195 386825..388684 1 NC_001147.5 Probable multiple transmembrane protein, involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; required for accumulation of processed Rim101p; Dfg16p 388684 DFG16 854195 DFG16 Saccharomyces cerevisiae Dfg16p NP_014673.1 386825 D 4932 CDS NP_014674.1 6324605 854196 389213..389422 1 NC_001147.5 Crs5p; Copper-binding metallothionein, required for wild-type copper resistance 389422 CRS5 854196 CRS5 Saccharomyces cerevisiae Copper-binding metallothionein, required for wild-type copper resistance NP_014674.1 389213 D 4932 CDS NP_014675.1 6324606 854197 complement(389771..391075) 1 NC_001147.5 Hms1p; Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant 391075 HMS1 854197 HMS1 Saccharomyces cerevisiae Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant NP_014675.1 389771 R 4932 CDS NP_878169.1 33438881 1466481 392176..392376 1 NC_001147.5 Yor032w-ap; Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 392376 1466481 YOR032W-A Saccharomyces cerevisiae Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching NP_878169.1 392176 D 4932 CDS NP_014676.1 6324607 854198 complement(392416..394524) 1 NC_001147.5 Exo1p; 5'-3' exonuclease and flap-endonuclease involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains 394524 EXO1 854198 EXO1 Saccharomyces cerevisiae 5'-3' exonuclease and flap-endonuclease involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains NP_014676.1 392416 R 4932 CDS NP_014677.1 6324608 854199 complement(394837..397086) 1 NC_001147.5 Ankyrin repeat-containing protein similar to Akr1p; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p; Akr2p 397086 AKR2 854199 AKR2 Saccharomyces cerevisiae Akr2p NP_014677.1 394837 R 4932 CDS NP_878170.1 33438882 1466482 complement(397426..397668) 1 NC_001147.5 Yor034c-ap; Putative protein of unknown function; identified by expression profiling and mass spectrometry 397668 1466482 YOR034C-A Saccharomyces cerevisiae Putative protein of unknown function; identified by expression profiling and mass spectrometry NP_878170.1 397426 R 4932 CDS NP_014678.1 6324609 854200 complement(397735..400104) 1 NC_001147.5 She4p; Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization 400104 SHE4 854200 SHE4 Saccharomyces cerevisiae Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization NP_014678.1 397735 R 4932 CDS NP_014679.1 6324610 854201 400348..401214 1 NC_001147.5 Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin; Pep12p 401214 PEP12 854201 PEP12 Saccharomyces cerevisiae Pep12p NP_014679.1 400348 D 4932 CDS NP_014680.2 37362694 854202 401555..402655 1 NC_001147.5 Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p); Cyc2p 402655 CYC2 854202 CYC2 Saccharomyces cerevisiae Cyc2p NP_014680.2 401555 D 4932 CDS NP_014681.1 6324612 854203 complement(402761..405388) 1 NC_001147.5 Non-essential transcriptional corepressor involved in the cell cycle-regulated transcription of histone H2A, H2B, H3, and H4 genes; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p; Hir2p 405388 HIR2 854203 HIR2 Saccharomyces cerevisiae Hir2p NP_014681.1 402761 R 4932 CDS NP_014682.1 6324613 854204 405768..406544 1 NC_001147.5 Ckb2p; Beta' regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB1, the many substrates include transcription factors and all RNA polymerases 406544 CKB2 854204 CKB2 Saccharomyces cerevisiae Beta' regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB1, the many substrates include transcription factors and all RNA polymerases NP_014682.1 405768 D 4932 CDS NP_014683.1 6324614 854205 407064..407921 1 NC_001147.5 Mitochondrial glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate; Glo4p 407921 GLO4 854205 GLO4 Saccharomyces cerevisiae Glo4p NP_014683.1 407064 D 4932 CDS NP_014685.1 6324615 854206 408425..409660 1 NC_001147.5 Protein containing a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; Cue5p 409660 CUE5 854206 CUE5 Saccharomyces cerevisiae Cue5p NP_014685.1 408425 D 4932 CDS NP_014686.1 6324617 854208 410870..412330 1 NC_001147.5 Whi2p; Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression 412330 WHI2 854208 WHI2 Saccharomyces cerevisiae Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression NP_014686.1 410870 D 4932 CDS NP_014687.1 6324618 854209 413007..413480 1 NC_001147.5 Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; null mutant displays increased levels of spontaneous Rad52 foci; Irc23p 413480 IRC23 854209 IRC23 Saccharomyces cerevisiae Irc23p NP_014687.1 413007 D 4932 CDS NP_014688.1 6324619 854210 413852..414037 1 NC_001147.5 Tom6p; Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex 414037 TOM6 854210 TOM6 Saccharomyces cerevisiae Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex NP_014688.1 413852 D 4932 CDS NP_014689.1 6324620 854211 complement(414460..415908) 1 NC_001147.5 Dbp5p; Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family involved in mRNA export from the nucleus; involved in translation termination 415908 DBP5 854211 DBP5 Saccharomyces cerevisiae Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family involved in mRNA export from the nucleus; involved in translation termination NP_014689.1 414460 R 4932 CDS NP_014690.1 6324621 854212 complement(416348..417682) 1 NC_001147.5 Std1p; Protein involved in control of glucose-regulated gene expression; interacts with protein kinase Snf1p, glucose sensors Snf3p and Rgt2p, and TATA-binding protein Spt15p; acts as a regulator of the transcription factor Rgt1p 417682 STD1 854212 STD1 Saccharomyces cerevisiae Protein involved in control of glucose-regulated gene expression; interacts with protein kinase Snf1p, glucose sensors Snf3p and Rgt2p, and TATA-binding protein Spt15p; acts as a regulator of the transcription factor Rgt1p NP_014690.1 416348 R 4932 CDS NP_014691.1 6324622 854213 complement(418631..421651) 1 NC_001147.5 Rat1p; Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as mRNA transcription termination 421651 RAT1 854213 RAT1 Saccharomyces cerevisiae Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as mRNA transcription termination NP_014691.1 418631 R 4932 CDS NP_014692.1 6324623 854214 complement(422669..423733) 1 NC_001147.5 Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane; Rsb1p 423733 RSB1 854214 RSB1 Saccharomyces cerevisiae Rsb1p NP_014692.1 422669 R 4932 CDS NP_014694.1 6324625 854216 complement(424848..426086) 1 NC_001147.5 Yor051cp; Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts 426086 854216 YOR051C Saccharomyces cerevisiae Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts NP_014694.1 424848 R 4932 CDS NP_014695.1 6324626 854217 complement(426774..427226) 1 NC_001147.5 Yor052cp; Nuclear protein of unknown function; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner and by weak acid 427226 854217 YOR052C Saccharomyces cerevisiae Nuclear protein of unknown function; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner and by weak acid NP_014695.1 426774 R 4932 CDS NP_014697.1 6324629 854220 complement(427835..429859) 1 NC_001147.5 Vhs3p; Functionally redundant (see also SIS2) inhibitory subunit of Ppz1p, a PP1c-related ser/thr protein phosphatase Z isoform; synthetically lethal with sis2; putative phosphopantothenoylcysteine decarboxylase involved in coenzyme A biosynthesis 429859 VHS3 854220 VHS3 Saccharomyces cerevisiae Functionally redundant (see also SIS2) inhibitory subunit of Ppz1p, a PP1c-related ser/thr protein phosphatase Z isoform; synthetically lethal with sis2; putative phosphopantothenoylcysteine decarboxylase involved in coenzyme A biosynthesis NP_014697.1 427835 R 4932 CDS NP_014699.1 6324630 854221 complement(430249..431628) 1 NC_001147.5 Nob1p; Essential nuclear protein involved in proteasome maturation and synthesis of 40S ribosomal subunits; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA 431628 NOB1 854221 NOB1 Saccharomyces cerevisiae Essential nuclear protein involved in proteasome maturation and synthesis of 40S ribosomal subunits; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA NP_014699.1 430249 R 4932 CDS NP_014700.1 6324631 854222 432188..433375 1 NC_001147.5 Sgt1p; Probable cochaperone, regulates activity of Cyr1p (adenylyl cyclase); involved in assembly of the kinetochore complex, associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex 433375 SGT1 854222 SGT1 Saccharomyces cerevisiae Probable cochaperone, regulates activity of Cyr1p (adenylyl cyclase); involved in assembly of the kinetochore complex, associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex NP_014700.1 432188 D 4932 CDS NP_116582.1 14318440 854223 complement(433690..436347) 1 NC_001147.5 Mitotic spindle midzone localized microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; Ase1p 436347 ASE1 854223 ASE1 Saccharomyces cerevisiae Ase1p NP_116582.1 433690 R 4932 CDS NP_014702.1 6324633 854225 complement(438908..440260) 1 NC_001147.5 Yor059cp 440260 854225 YOR059C Saccharomyces cerevisiae Yor059cp NP_014702.1 438908 R 4932 CDS NP_014703.1 6324634 854226 complement(440392..441165) 1 NC_001147.5 Yor060cp; Protein of unknown function required for cell viability; deletion mutant harbors aberrant mitochondria 441165 854226 YOR060C Saccharomyces cerevisiae Protein of unknown function required for cell viability; deletion mutant harbors aberrant mitochondria NP_014703.1 440392 R 4932 CDS NP_014704.1 6324635 854227 441536..442555 1 NC_001147.5 Cka2p; Alpha' catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases 442555 CKA2 854227 CKA2 Saccharomyces cerevisiae Alpha' catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases NP_014704.1 441536 D 4932 CDS NP_014705.1 6324636 854228 complement(442727..443533) 1 NC_001147.5 Yor062cp; Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS 443533 854228 YOR062C Saccharomyces cerevisiae Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS NP_014705.1 442727 R 4932 CDS NP_014706.1 6324637 854229 444688..445851 1 NC_001147.5 Rpl3p; Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus 445851 RPL3 854229 RPL3 Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus NP_014706.1 444688 D 4932 CDS NP_014707.1 6324638 854230 complement(446081..446740) 1 NC_001147.5 Yng1p; Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3, has similarity to the human tumor suppressor ING1 446740 YNG1 854230 YNG1 Saccharomyces cerevisiae Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3, has similarity to the human tumor suppressor ING1 NP_014707.1 446081 R 4932 CDS NP_014708.1 6324639 854231 447441..448370 1 NC_001147.5 Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex; Cyt1p 448370 CYT1 854231 CYT1 Saccharomyces cerevisiae Cyt1p NP_014708.1 447441 D 4932 CDS NP_014709.1 6324640 854232 449438..451327 1 NC_001147.5 Msa1p; Activator of G1-specific transcription factors, MBF and SBF, that regulates both the timing of G1-specific gene transcription, and cell cycle initiation; potential Cdc28p substrate 451327 MSA1 854232 MSA1 Saccharomyces cerevisiae Activator of G1-specific transcription factors, MBF and SBF, that regulates both the timing of G1-specific gene transcription, and cell cycle initiation; potential Cdc28p substrate NP_014709.1 449438 D 4932 CDS NP_014710.1 6324641 854233 complement(451731..453464) 1 NC_001147.5 Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p; Alg8p 453464 ALG8 854233 ALG8 Saccharomyces cerevisiae Alg8p NP_014710.1 451731 R 4932 CDS NP_014712.2 46562125 854235 453770..455797 1 NC_001147.5 Vps5p; Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p 455797 VPS5 854235 VPS5 Saccharomyces cerevisiae Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p NP_014712.2 453770 D 4932 CDS NP_014711.1 6324642 854234 complement(453871..454215) 1 NC_001147.5 Vam10p; Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering 454215 VAM10 854234 VAM10 Saccharomyces cerevisiae Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering NP_014711.1 453871 R 4932 CDS NP_014713.1 6324644 854236 complement(455909..457822) 1 NC_001147.5 Gyp1p; Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion 457822 GYP1 854236 GYP1 Saccharomyces cerevisiae Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion NP_014713.1 455909 R 4932 CDS NP_014714.1 6324645 854237 complement(459482..461278) 1 NC_001147.5 Transporter of thiamine or related compound; shares sequence similarity to Thi7p; proposed to be involved in 5-fluorocytosine sensitivity; Thi71p 461278 THI71 854237 THI71 Saccharomyces cerevisiae Thi71p NP_014714.1 459482 R 4932 CDS NP_878171.1 33438883 1466483 464471..464632 1 NC_001147.5 Yor072w-bp; Putative protein of unknown function; identified by expression profiling and mass spectrometry 464632 1466483 YOR072W-B Saccharomyces cerevisiae Putative protein of unknown function; identified by expression profiling and mass spectrometry NP_878171.1 464471 D 4932 CDS NP_014716.1 6324647 854240 464773..466545 1 NC_001147.5 Sgo1p; Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability 466545 SGO1 854240 SGO1 Saccharomyces cerevisiae Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability NP_014716.1 464773 D 4932 CDS NP_014717.2 83578104 854241 complement(466677..467591) 1 NC_001147.5 Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S; Cdc21p 467591 CDC21 854241 CDC21 Saccharomyces cerevisiae Cdc21p NP_014717.2 466677 R 4932 CDS NP_014718.1 6324649 854242 468214..469254 1 NC_001147.5 t-SNARE required for ER membrane fusion and vesicular traffic, integral membrane protein that constitutes with Sec20p and Use1p the trimeric acceptor for R/v-SNAREs on Golgi-derived vesicles at the ER; part of Dsl1p complex; Ufe1p 469254 UFE1 854242 UFE1 Saccharomyces cerevisiae Ufe1p NP_014718.1 468214 D 4932 CDS NP_014719.1 6324650 854243 complement(469379..471622) 1 NC_001147.5 Ski7p; Putative GTPase that mediates interactions via its N-terminus between the exosome and Ski complex (Ski2p, Ski3p, Ski8p) which operate in the 3'-to-5' mRNA-decay pathway; cytoplasmic protein required for degrading nonstop mRNAs 471622 SKI7 854243 SKI7 Saccharomyces cerevisiae Putative GTPase that mediates interactions via its N-terminus between the exosome and Ski complex (Ski2p, Ski3p, Ski8p) which operate in the 3'-to-5' mRNA-decay pathway; cytoplasmic protein required for degrading nonstop mRNAs NP_014719.1 469379 R 4932 CDS NP_014720.1 6324651 854244 471901..472599 1 NC_001147.5 Rts2p; Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication 472599 RTS2 854244 RTS2 Saccharomyces cerevisiae Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication NP_014720.1 471901 D 4932 CDS NP_014721.1 6324652 854245 472727..473371 1 NC_001147.5 Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern; Bud21p 473371 BUD21 854245 BUD21 Saccharomyces cerevisiae Bud21p NP_014721.1 472727 D 4932 CDS NP_014722.1 6324653 854246 complement(473477..474418) 1 NC_001147.5 Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation; Atx2p 474418 ATX2 854246 ATX2 Saccharomyces cerevisiae Atx2p NP_014722.1 473477 R 4932 CDS NP_014723.1 6324654 854247 474554..476794 1 NC_001147.5 Origin-binding F-box protein that forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication, involved in invasive and pseudohyphal growth; Dia2p 476794 DIA2 854247 DIA2 Saccharomyces cerevisiae Dia2p NP_014723.1 474554 D 4932 CDS NP_014724.1 6324655 854248 complement(476941..479190) 1 NC_001147.5 Triacylglycerol lipase involved in TAG mobilization; localizes to lipid particles; potential Cdc28p substrate; Tgl5p 479190 TGL5 854248 TGL5 Saccharomyces cerevisiae Tgl5p NP_014724.1 476941 R 4932 CDS NP_014726.1 6324656 854249 479535..480422 1 NC_001147.5 Whi5p; Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1 480422 WHI5 854249 WHI5 Saccharomyces cerevisiae Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1 NP_014726.1 479535 D 4932 CDS NP_014727.1 6324658 854251 480589..481752 1 NC_001147.5 Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction; Lpx1p 481752 LPX1 854251 LPX1 Saccharomyces cerevisiae Lpx1p NP_014727.1 480589 D 4932 CDS NP_014728.1 6324659 854252 482035..483087 1 NC_001147.5 Ost3p; Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins 483087 OST3 854252 OST3 Saccharomyces cerevisiae Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins NP_014728.1 482035 D 4932 CDS NP_014729.1 6324660 854253 complement(483221..486781) 1 NC_001147.5 Tcb1p; Lipid-binding protein containing three calcium and lipid binding domains; non-tagged protein localizes to mitochondria and GFP-fusion protein localizes to the cell periphery; C-termini of Tcb1p, Tcb2p and Tcb3p interact 486781 TCB1 854253 TCB1 Saccharomyces cerevisiae Lipid-binding protein containing three calcium and lipid binding domains; non-tagged protein localizes to mitochondria and GFP-fusion protein localizes to the cell periphery; C-termini of Tcb1p, Tcb2p and Tcb3p interact NP_014729.1 483221 R 4932 CDS NP_014730.2 27808717 854255 487709..489736 1 NC_001147.5 Yvc1p; Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock 489736 YVC1 854255 YVC1 Saccharomyces cerevisiae Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock NP_014730.2 487709 D 4932 CDS NP_014732.1 6324663 854256 complement(490198..490830) 1 NC_001147.5 Vps21p; GTPase required for transport during endocytosis and for correct sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog 490830 VPS21 854256 VPS21 Saccharomyces cerevisiae GTPase required for transport during endocytosis and for correct sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog NP_014732.1 490198 R 4932 CDS NP_014733.1 6324664 854257 complement(491125..492843) 1 NC_001147.5 Ptc5p; Mitochondrially localized type 2C protein phosphatase involved in regulation of pyruvate dehydrogenase activity; contains Mg2+/Mn2+-dependent casein phosphatase activity in vitro 492843 PTC5 854257 PTC5 Saccharomyces cerevisiae Mitochondrially localized type 2C protein phosphatase involved in regulation of pyruvate dehydrogenase activity; contains Mg2+/Mn2+-dependent casein phosphatase activity in vitro NP_014733.1 491125 R 4932 CDS NP_014734.2 83578105 854258 493434..494471 1 NC_001147.5 Tma46p; Protein of unknown function that associates with ribosomes; interacts with GTPase Rbg1p 494471 TMA46 854258 TMA46 Saccharomyces cerevisiae Protein of unknown function that associates with ribosomes; interacts with GTPase Rbg1p NP_014734.2 493434 D 4932 CDS NP_014735.1 6324666 854259 495128..496969 1 NC_001147.5 Non-essential protein of unknown function; Ecm3p 496969 ECM3 854259 ECM3 Saccharomyces cerevisiae Ecm3p NP_014735.1 495128 D 4932 CDS NP_014736.1 6324667 854260 complement(497507..502453) 1 NC_001147.5 Yor093cp; Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents 502453 854260 YOR093C Saccharomyces cerevisiae Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents NP_014736.1 497507 R 4932 CDS NP_014737.1 6324668 854261 502796..503347 1 NC_001147.5 Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; Arf3p 503347 ARF3 854261 ARF3 Saccharomyces cerevisiae Arf3p NP_014737.1 502796 D 4932 CDS NP_014738.1 6324669 854262 complement(503553..504329) 1 NC_001147.5 Rki1p; Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis 504329 RKI1 854262 RKI1 Saccharomyces cerevisiae Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis NP_014738.1 503553 R 4932 CDS NP_014739.1 6324670 854263 join(505795..505938,506340..506768) 1 NC_001147.5 Rps7ap; Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins 506768 RPS7A 854263 RPS7A Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins NP_014739.1 505795 D 4932 CDS NP_014740.1 6324671 854264 complement(506979..507506) 1 NC_001147.5 Yor097cp; Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene 507506 854264 YOR097C Saccharomyces cerevisiae Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene NP_014740.1 506979 R 4932 CDS NP_014741.1 6324672 854265 complement(507949..511179) 1 NC_001147.5 Nup1p; Nuclear pore complex (NPC) subunit, involved in protein import/export and in export of RNAs, possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; potential Cdc28p substrate 511179 NUP1 854265 NUP1 Saccharomyces cerevisiae Nuclear pore complex (NPC) subunit, involved in protein import/export and in export of RNAs, possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; potential Cdc28p substrate NP_014741.1 507949 R 4932 CDS NP_014742.1 6324673 854266 511826..513007 1 NC_001147.5 Ktr1p; Alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family 513007 KTR1 854266 KTR1 Saccharomyces cerevisiae Alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family NP_014742.1 511826 D 4932 CDS NP_014743.1 6324674 854267 complement(513296..514279) 1 NC_001147.5 Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation; Crc1p 514279 CRC1 854267 CRC1 Saccharomyces cerevisiae Crc1p NP_014743.1 513296 R 4932 CDS NP_014744.1 6324675 854268 515245..516174 1 NC_001147.5 Ras1p; GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes 516174 RAS1 854268 RAS1 Saccharomyces cerevisiae GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes NP_014744.1 515245 D 4932 CDS NP_014746.2 37362695 854270 complement(516450..516842) 1 NC_001147.5 Ost2p; Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins 516842 OST2 854270 OST2 Saccharomyces cerevisiae Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins NP_014746.2 516450 R 4932 CDS NP_014747.1 6324678 854271 517643..518491 1 NC_001147.5 Protein that induces appearance of [PIN+] prion when overproduced; Pin2p 518491 PIN2 854271 PIN2 Saccharomyces cerevisiae Pin2p NP_014747.1 517643 D 4932 CDS NP_014749.1 6324680 854273 519122..519973 1 NC_001147.5 Vam3p; Syntaxin-related protein required for vacuolar assembly; functions with Vam7p in vacuolar protein trafficking; member of the syntaxin family of proteins 519973 VAM3 854273 VAM3 Saccharomyces cerevisiae Syntaxin-related protein required for vacuolar assembly; functions with Vam7p in vacuolar protein trafficking; member of the syntaxin family of proteins NP_014749.1 519122 D 4932 CDS NP_014750.1 6324681 854274 521354..522283 1 NC_001147.5 Rgs2p; Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p 522283 RGS2 854274 RGS2 Saccharomyces cerevisiae Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p NP_014750.1 521354 D 4932 CDS NP_014751.1 6324682 854275 523028..524842 1 NC_001147.5 Leu9p; Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant 524842 LEU9 854275 LEU9 Saccharomyces cerevisiae Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant NP_014751.1 523028 D 4932 CDS NP_014752.1 6324683 854276 525279..528602 1 NC_001147.5 Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains; Inp53p 528602 INP53 854276 INP53 Saccharomyces cerevisiae Inp53p NP_014752.1 525279 D 4932 CDS NP_014753.1 6324684 854277 528942..530249 1 NC_001147.5 Tfc7p; One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes 530249 TFC7 854277 TFC7 Saccharomyces cerevisiae One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes NP_014753.1 528942 D 4932 CDS NP_014754.1 6324685 854278 530430..531128 1 NC_001147.5 Yor111wp; Putative protein of unknown function 531128 854278 YOR111W Saccharomyces cerevisiae Putative protein of unknown function NP_014754.1 530430 D 4932 CDS NP_014755.1 6324686 854279 531509..533794 1 NC_001147.5 Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p; Cex1p 533794 CEX1 854279 CEX1 Saccharomyces cerevisiae Cex1p NP_014755.1 531509 D 4932 CDS NP_014756.1 6324687 854280 534076..536820 1 NC_001147.5 Zinc-finger transcription factor, involved in induction of CLN3 transcription in response to glucose; genetic and physical interactions indicate a possible role in mitochondrial transcription or genome maintenance; Azf1p 536820 AZF1 854280 AZF1 Saccharomyces cerevisiae Azf1p NP_014756.1 534076 D 4932 CDS NP_014757.1 6324688 854281 537571..538455 1 NC_001147.5 Yor114wp 538455 854281 YOR114W Saccharomyces cerevisiae Yor114wp NP_014757.1 537571 D 4932 CDS NP_014758.1 6324689 854282 complement(538660..539466) 1 NC_001147.5 Trs33p; One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic 539466 TRS33 854282 TRS33 Saccharomyces cerevisiae One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic NP_014758.1 538660 R 4932 CDS NP_014759.1 6324690 854283 complement(539764..544146) 1 NC_001147.5 Rpo31p; RNA polymerase III subunit C160, part of core enzyme; similar to bacterial beta-prime subunit 544146 RPO31 854283 RPO31 Saccharomyces cerevisiae RNA polymerase III subunit C160, part of core enzyme; similar to bacterial beta-prime subunit NP_014759.1 539764 R 4932 CDS NP_014760.1 6324691 854284 545030..546334 1 NC_001147.5 Rpt5p; One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription 546334 RPT5 854284 RPT5 Saccharomyces cerevisiae One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription NP_014760.1 545030 D 4932 CDS NP_014761.1 6324692 854285 546858..548561 1 NC_001147.5 Yor118wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR118W is not an essential gene 548561 854285 YOR118W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR118W is not an essential gene NP_014761.1 546858 D 4932 CDS NP_014762.1 6324693 854286 complement(548793..550247) 1 NC_001147.5 Rio1p; Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA 550247 RIO1 854286 RIO1 Saccharomyces cerevisiae Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA NP_014762.1 548793 R 4932 CDS NP_014763.1 6324694 854287 551115..552053 1 NC_001147.5 Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) family; Gcy1p 552053 GCY1 854287 GCY1 Saccharomyces cerevisiae Gcy1p NP_014763.1 551115 D 4932 CDS NP_014765.1 6324696 854289 complement(join(552299..552666,552876..552888)) 1 NC_001147.5 Profilin, actin- and phosphatidylinositol 4,5-bisphosphate-binding protein, involved in cytoskeleton organization, required for normal timing of actin polymerization in response to thermal stress; localizes to plasma membrane and cytosol; Pfy1p 552888 PFY1 854289 PFY1 Saccharomyces cerevisiae Pfy1p NP_014765.1 552299 R 4932 CDS NP_014766.1 6324697 854290 complement(553177..554571) 1 NC_001147.5 Leo1p; Component of the Paf1 complex, which associates with RNA polymerase II and is involved in histone methylation 554571 LEO1 854290 LEO1 Saccharomyces cerevisiae Component of the Paf1 complex, which associates with RNA polymerase II and is involved in histone methylation NP_014766.1 553177 R 4932 CDS NP_014767.1 6324698 854291 complement(554825..558643) 1 NC_001147.5 Ubp2p; Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins, cleaves at the C terminus of ubiquitin fusions; capable of cleaving polyubiquitin and possesses isopeptidase activity 558643 UBP2 854291 UBP2 Saccharomyces cerevisiae Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins, cleaves at the C terminus of ubiquitin fusions; capable of cleaving polyubiquitin and possesses isopeptidase activity NP_014767.1 554825 R 4932 CDS NP_014768.2 37362696 854292 complement(559031..559732) 1 NC_001147.5 Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation; Cat5p 559732 CAT5 854292 CAT5 Saccharomyces cerevisiae Cat5p NP_014768.2 559031 R 4932 CDS NP_014769.1 6324700 854293 complement(559962..560678) 1 NC_001147.5 Isoamyl acetate-hydrolyzing esterase, required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing; Iah1p 560678 IAH1 854293 IAH1 Saccharomyces cerevisiae Iah1p NP_014769.1 559962 R 4932 CDS NP_014770.1 6324701 854294 561171..564194 1 NC_001147.5 Rga1p; GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth 564194 RGA1 854294 RGA1 Saccharomyces cerevisiae GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth NP_014770.1 561171 D 4932 CDS NP_014771.1 6324702 854295 complement(564477..566192) 1 NC_001147.5 Phosphoribosylaminoimidazole carboxylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; red pigment accumulates in mutant cells deprived of adenine; Ade2p 566192 ADE2 854295 ADE2 Saccharomyces cerevisiae Ade2p NP_014771.1 564477 R 4932 CDS NP_014772.1 6324703 854296 complement(566878..569559) 1 NC_001147.5 Yor129cp; Putative component of the outer plaque of the spindle pole body; may be involved in cation homeostasis or multidrug resistance 569559 854296 YOR129C Saccharomyces cerevisiae Putative component of the outer plaque of the spindle pole body; may be involved in cation homeostasis or multidrug resistance NP_014772.1 566878 R 4932 CDS NP_014773.1 6324704 854297 complement(569930..570808) 1 NC_001147.5 Ort1p; Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome 570808 ORT1 854297 ORT1 Saccharomyces cerevisiae Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome NP_014773.1 569930 R 4932 CDS NP_014774.1 6324705 854299 complement(572183..572839) 1 NC_001147.5 Yor131cp; Putative protein of unknown function; non-essential gene 572839 854299 YOR131C Saccharomyces cerevisiae Putative protein of unknown function; non-essential gene NP_014774.1 572183 R 4932 CDS NP_014775.1 6324706 854300 573176..574831 1 NC_001147.5 Vps17p; Subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation 574831 VPS17 854300 VPS17 Saccharomyces cerevisiae Subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation NP_014775.1 573176 D 4932 CDS NP_014776.1 6324707 854301 575099..577627 1 NC_001147.5 Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; Eft1p 577627 EFT1 854301 EFT1 Saccharomyces cerevisiae Eft1p NP_014776.1 575099 D 4932 CDS NP_014777.1 6324708 854302 578565..579794 1 NC_001147.5 Rho GTPase activating protein (RhoGAP), stimulates the intrinsic GTPase activity of Rho1p, which plays a role in actin cytoskeleton organization and control of cell wall synthesis; structurally and functionally related to Sac7p; Bag7p 579794 BAG7 854302 BAG7 Saccharomyces cerevisiae Bag7p NP_014777.1 578565 D 4932 CDS NP_014779.1 6324709 854303 580251..581360 1 NC_001147.5 Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated; Idh2p 581360 IDH2 854303 IDH2 Saccharomyces cerevisiae Idh2p NP_014779.1 580251 D 4932 CDS NP_014780.1 6324711 854305 complement(581814..583682) 1 NC_001147.5 Sia1p; Protein of unassigned function involved in activation of the Pma1p plasma membrane H+-ATPase by glucose 583682 SIA1 854305 SIA1 Saccharomyces cerevisiae Protein of unassigned function involved in activation of the Pma1p plasma membrane H+-ATPase by glucose NP_014780.1 581814 R 4932 CDS NP_014781.1 6324712 854306 complement(584310..586325) 1 NC_001147.5 Rup1p; Protein involved in regulation of Rsp5p, which is an essential HECT ubiquitin ligase; required for binding of Rsp5p to Ubp2p; contains an UBA domain 586325 RUP1 854306 RUP1 Saccharomyces cerevisiae Protein involved in regulation of Rsp5p, which is an essential HECT ubiquitin ligase; required for binding of Rsp5p to Ubp2p; contains an UBA domain NP_014781.1 584310 R 4932 CDS NP_014783.1 6324713 854307 586982..589282 1 NC_001147.5 Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p; Sfl1p 589282 SFL1 854307 SFL1 Saccharomyces cerevisiae Sfl1p NP_014783.1 586982 D 4932 CDS NP_014784.1 6324715 854309 complement(589943..592588) 1 NC_001147.5 Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; Arp8p 592588 ARP8 854309 ARP8 Saccharomyces cerevisiae Arp8p NP_014784.1 589943 R 4932 CDS NP_014785.1 6324716 854310 593058..594047 1 NC_001147.5 Lsc1p; Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated 594047 LSC1 854310 LSC1 Saccharomyces cerevisiae Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated NP_014785.1 593058 D 4932 CDS NP_058183.1 7839199 854313 join(595113..596417,596419..600381) 1 NC_001147.5 Yor142w-bp; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 600381 854313 YOR142W-B Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_058183.1 595113 D 4932 CDS NP_058184.1 7839198 854312 595113..596435 1 NC_001147.5 Yor142w-ap; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 596435 854312 YOR142W-A Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_058184.1 595113 D 4932 CDS NP_014786.1 6324717 854314 complement(601384..602343) 1 NC_001147.5 Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate); Thi80p 602343 THI80 854314 THI80 Saccharomyces cerevisiae Thi80p NP_014786.1 601384 R 4932 CDS NP_014787.1 6324718 854315 complement(602718..605093) 1 NC_001147.5 Protein required for S phase progression and telomere homeostasis, forms an alternative replication factor C complex important for DNA replication and genome integrity; involved in homologous recombination-mediated DNA repair; Elg1p 605093 ELG1 854315 ELG1 Saccharomyces cerevisiae Elg1p NP_014787.1 602718 R 4932 CDS NP_014788.1 6324720 854317 complement(605348..606172) 1 NC_001147.5 Pno1p; Essential nucleolar protein required for pre-18S rRNA processing, interacts with Dim1p, an 18S rRNA dimethyltransferase, and also with Nob1p, which is involved in proteasome biogenesis; contains a KH domain 606172 PNO1 854317 PNO1 Saccharomyces cerevisiae Essential nucleolar protein required for pre-18S rRNA processing, interacts with Dim1p, an 18S rRNA dimethyltransferase, and also with Nob1p, which is involved in proteasome biogenesis; contains a KH domain NP_014788.1 605348 R 4932 CDS NP_014790.2 83578106 854318 606608..608476 1 NC_001147.5 Mitochondrial inner membrane protein with similarity to Mdm31p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34; Mdm32p 608476 MDM32 854318 MDM32 Saccharomyces cerevisiae Mdm32p NP_014790.2 606608 D 4932 CDS NP_014791.1 6324722 854319 complement(608641..609198) 1 NC_001147.5 Spp2p; Essential protein that promotes the first step of splicing and is required for the final stages of spliceosome maturation; interacts with Prp2p, which may release Spp2p from the spliceosome following the first cleavage reaction 609198 SPP2 854319 SPP2 Saccharomyces cerevisiae Essential protein that promotes the first step of splicing and is required for the final stages of spliceosome maturation; interacts with Prp2p, which may release Spp2p from the spliceosome following the first cleavage reaction NP_014791.1 608641 R 4932 CDS NP_014792.1 6324723 854320 complement(609839..611389) 1 NC_001147.5 Smp3p; Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure 611389 SMP3 854320 SMP3 Saccharomyces cerevisiae Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure NP_014792.1 609839 R 4932 CDS NP_014793.1 6324724 854321 612000..612491 1 NC_001147.5 Mrpl23p; Mitochondrial ribosomal protein of the large subunit 612491 MRPL23 854321 MRPL23 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit NP_014793.1 612000 D 4932 CDS NP_014794.1 6324725 854322 complement(612998..616672) 1 NC_001147.5 Rpb2p; RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit 616672 RPB2 854322 RPB2 Saccharomyces cerevisiae RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit NP_014794.1 612998 R 4932 CDS NP_014795.1 6324726 854323 complement(617519..618289) 1 NC_001147.5 Yor152cp; Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene 618289 854323 YOR152C Saccharomyces cerevisiae Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene NP_014795.1 617519 R 4932 CDS NP_014796.1 6324727 854324 619841..624376 1 NC_001147.5 Plasma membrane ATP-binding cassette (ABC) transporter, short-lived multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth; Pdr5p 624376 PDR5 854324 PDR5 Saccharomyces cerevisiae Pdr5p NP_014796.1 619841 D 4932 CDS NP_014797.1 6324728 854325 624730..626493 1 NC_001147.5 Slp1p; Integral membrane protein of unknown function; member of the SUN-like family of proteins 626493 SLP1 854325 SLP1 Saccharomyces cerevisiae Integral membrane protein of unknown function; member of the SUN-like family of proteins NP_014797.1 624730 D 4932 CDS NP_014798.1 6324729 854326 complement(626629..627981) 1 NC_001147.5 Isn1p; Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms 627981 ISN1 854326 ISN1 Saccharomyces cerevisiae Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms NP_014798.1 626629 R 4932 CDS NP_014799.1 6324730 854327 complement(628361..630541) 1 NC_001147.5 SUMO ligase, catalyzes the covalent attachment of SUMO (Smt3p) to proteins; involved in maintenance of proper telomere length; Nfi1p 630541 NFI1 854327 NFI1 Saccharomyces cerevisiae Nfi1p NP_014799.1 628361 R 4932 CDS NP_014800.1 6324731 854328 complement(630967..631752) 1 NC_001147.5 Pup1p; Endopeptidase with trypsin-like activity that cleaves after basic residues; beta-type subunit of 20S proteasome synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z 631752 PUP1 854328 PUP1 Saccharomyces cerevisiae Endopeptidase with trypsin-like activity that cleaves after basic residues; beta-type subunit of 20S proteasome synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z NP_014800.1 630967 R 4932 CDS NP_014801.1 6324732 854329 632165..633121 1 NC_001147.5 Pet123p; Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator 633121 PET123 854329 PET123 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator NP_014801.1 632165 D 4932 CDS NP_014802.1 6324733 854330 complement(633283..633567) 1 NC_001147.5 Sme1p; Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E 633567 SME1 854330 SME1 Saccharomyces cerevisiae Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E NP_014802.1 633283 R 4932 CDS NP_014803.1 6324734 854331 633840..636758 1 NC_001147.5 Nuclear import receptor, mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; Mtr10p 636758 MTR10 854331 MTR10 Saccharomyces cerevisiae Mtr10p NP_014803.1 633840 D 4932 CDS NP_014804.1 6324735 854332 complement(636940..638559) 1 NC_001147.5 Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport; Pns1p 638559 PNS1 854332 PNS1 Saccharomyces cerevisiae Pns1p NP_014804.1 636940 R 4932 CDS NP_878172.1 33438884 1466484 complement(639122..639268) 1 NC_001147.5 Yor161c-cp; Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 639268 1466484 YOR161C-C Saccharomyces cerevisiae Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching NP_878172.1 639122 R 4932 CDS NP_014805.1 6324736 854333 complement(639561..641993) 1 NC_001147.5 Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; Yrr1p 641993 YRR1 854333 YRR1 Saccharomyces cerevisiae Yrr1p NP_014805.1 639561 R 4932 CDS NP_014806.1 6324737 854334 642742..643308 1 NC_001147.5 Diadenosine polyphosphate hydrolase, member of the MutT family of nucleotide hydrolases with high specificity for diadenosine hexa- and pentaphosphates, required for efficient hydrolysis of diphosphorylated inositol polyphosphates; Ddp1p 643308 DDP1 854334 DDP1 Saccharomyces cerevisiae Ddp1p NP_014806.1 642742 D 4932 CDS NP_014807.1 6324738 854335 complement(643395..644333) 1 NC_001147.5 Yor164cp; Protein of unknown function; interacts with Mdy2p 644333 854335 YOR164C Saccharomyces cerevisiae Protein of unknown function; interacts with Mdy2p NP_014807.1 643395 R 4932 CDS NP_014808.1 6324739 854336 644567..646897 1 NC_001147.5 Sey1p; Protein of unknown function, contains two predicted GTP-binding motifs GXXXXGKS and DXXG near the N-terminus, homolog of the Arabidopsis gene RHD3 (Root Hair Defective) 646897 SEY1 854336 SEY1 Saccharomyces cerevisiae Protein of unknown function, contains two predicted GTP-binding motifs GXXXXGKS and DXXG near the N-terminus, homolog of the Arabidopsis gene RHD3 (Root Hair Defective) NP_014808.1 644567 D 4932 CDS NP_014809.1 6324740 854337 complement(647127..648503) 1 NC_001147.5 Swt1p; Protein of unknown function; involved in transcription associated process; interacts genetically and physically with the TREX complex and RNA polymerase II; contains a PINc domain (PilT N terminus); localizes in the nucleus 648503 SWT1 854337 SWT1 Saccharomyces cerevisiae Protein of unknown function; involved in transcription associated process; interacts genetically and physically with the TREX complex and RNA polymerase II; contains a PINc domain (PilT N terminus); localizes in the nucleus NP_014809.1 647127 R 4932 CDS NP_014810.1 6324741 854338 complement(648805..649008) 1 NC_001147.5 Rps28ap; Protein component of the small (40S) ribosomal subunit; nearly identical to Rps28Bp and has similarity to rat S28 ribosomal protein 649008 RPS28A 854338 RPS28A Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit; nearly identical to Rps28Bp and has similarity to rat S28 ribosomal protein NP_014810.1 648805 R 4932 CDS NP_014811.1 6324742 854339 649304..651733 1 NC_001147.5 Glutamine tRNA synthetase, monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu); N-terminal domain proposed to be involved in enzyme-tRNA interactions; Gln4p 651733 GLN4 854339 GLN4 Saccharomyces cerevisiae Gln4p NP_014811.1 649304 D 4932 CDS NP_014814.1 6324745 854342 complement(652011..653885) 1 NC_001147.5 Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes; Lcb4p 653885 LCB4 854342 LCB4 Saccharomyces cerevisiae Lcb4p NP_014814.1 652011 R 4932 CDS NP_014815.1 6324746 854343 654211..656571 1 NC_001147.5 Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes; Yrm1p 656571 YRM1 854343 YRM1 Saccharomyces cerevisiae Yrm1p NP_014815.1 654211 D 4932 CDS NP_014816.2 116006500 854344 657265..658326 1 NC_001147.5 Non-essential, stress induced regulatory protein containing a HIT (histidine triad) motif; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway, similar to Dcs1p.; Dcs2p 658326 DCS2 854344 DCS2 Saccharomyces cerevisiae Dcs2p NP_014816.2 657265 D 4932 CDS NP_014817.1 6324748 854345 658748..659602 1 NC_001147.5 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; Med4p 659602 MED4 854345 MED4 Saccharomyces cerevisiae Med4p NP_014817.1 658748 D 4932 CDS NP_014818.1 6324749 854346 complement(659816..661675) 1 NC_001147.5 Lysophospholipid acyltransferase, partially redundant with Slc1p; part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids; Ale1p 661675 ALE1 854346 ALE1 Saccharomyces cerevisiae Ale1p NP_014818.1 659816 R 4932 CDS NP_014819.1 6324750 854347 662402..663583 1 NC_001147.5 Hem15p; Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway 663583 HEM15 854347 HEM15 Saccharomyces cerevisiae Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway NP_014819.1 662402 D 4932 CDS NP_014820.1 6324751 854349 complement(665786..667180) 1 NC_001147.5 Mpc54p; Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate 667180 MPC54 854349 MPC54 Saccharomyces cerevisiae Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate NP_014820.1 665786 R 4932 CDS NP_014821.1 6324752 854350 complement(667861..670242) 1 NC_001147.5 Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock; Gac1p 670242 GAC1 854350 GAC1 Saccharomyces cerevisiae Gac1p NP_014821.1 667861 R 4932 CDS NP_014822.1 6324753 854351 complement(671846..672412) 1 NC_001147.5 Syc1p; Subunit of the APT subcomplex of cleavage and polyadenylation factor, may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs 672412 SYC1 854351 SYC1 Saccharomyces cerevisiae Subunit of the APT subcomplex of cleavage and polyadenylation factor, may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs NP_014822.1 671846 R 4932 CDS NP_014823.1 6324754 854352 complement(674353..675168) 1 NC_001147.5 Peroxisomal delta(3,5)-delta(2,4)-dienoyl-CoA isomerase, involved in fatty acid metabolism, contains peroxisome targeting signals at amino and carboxy termini; Dci1p 675168 DCI1 854352 DCI1 Saccharomyces cerevisiae Dci1p NP_014823.1 674353 R 4932 CDS NP_014824.1 6324755 854353 675940..677841 1 NC_001147.5 Las17p; Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP) 677841 LAS17 854353 LAS17 Saccharomyces cerevisiae Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP) NP_014824.1 675940 D 4932 CDS NP_014825.1 6324756 854354 complement(join(678192..678380,678792..678794)) 1 NC_001147.5 Rps30bp; Protein component of the small (40S) ribosomal subunit; nearly identical to Rps30Ap and has similarity to rat S30 ribosomal protein 678794 RPS30B 854354 RPS30B Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit; nearly identical to Rps30Ap and has similarity to rat S30 ribosomal protein NP_014825.1 678192 R 4932 CDS NP_014826.1 6324757 854355 678873..679262 1 NC_001147.5 Protein of unknown function, required for survival upon exposure to K1 killer toxin; Fyv12p 679262 FYV12 854355 FYV12 Saccharomyces cerevisiae Fyv12p NP_014826.1 678873 D 4932 CDS NP_014827.1 6324758 854356 679358..680545 1 NC_001147.5 Ser1p; 3-phosphoserine aminotransferase, catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p 680545 SER1 854356 SER1 Saccharomyces cerevisiae 3-phosphoserine aminotransferase, catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p NP_014827.1 679358 D 4932 CDS NP_014828.1 6324759 854357 complement(681445..682107) 1 NC_001147.5 Gsp2p; GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability 682107 GSP2 854357 GSP2 Saccharomyces cerevisiae GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability NP_014828.1 681445 R 4932 CDS NP_014829.1 6324760 854358 683112..683546 1 NC_001147.5 Yor186wp; Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent 683546 854358 YOR186W Saccharomyces cerevisiae Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent NP_014829.1 683112 D 4932 CDS NP_014830.1 6324761 854359 684031..685344 1 NC_001147.5 Tuf1p; Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans 685344 TUF1 854359 TUF1 Saccharomyces cerevisiae Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans NP_014830.1 684031 D 4932 CDS NP_014831.1 6324762 854360 685768..689181 1 NC_001147.5 Protein involved in positive regulation of both 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway, potential Cdc28p substrate; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; Msb1p 689181 MSB1 854360 MSB1 Saccharomyces cerevisiae Msb1p NP_014831.1 685768 D 4932 CDS NP_014832.1 6324763 854361 689625..689975 1 NC_001147.5 Ies4p; Component of the INO80 chromatiin remodeling complex and target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses 689975 IES4 854361 IES4 Saccharomyces cerevisiae Component of the INO80 chromatiin remodeling complex and target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses NP_014832.1 689625 D 4932 CDS NP_014833.1 6324764 854362 690696..692033 1 NC_001147.5 Spr1p; Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance 692033 SPR1 854362 SPR1 Saccharomyces cerevisiae Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance NP_014833.1 690696 D 4932 CDS NP_014834.1 6324765 854363 692476..697335 1 NC_001147.5 Ris1p; Member of the SWI/SNF family of DNA-dependent ATPases, plays a role in antagonizing silencing during mating-type switching, contains an N-terminal domain that interacts with Sir4p and a C-terminal SNF2 domain 697335 RIS1 854363 RIS1 Saccharomyces cerevisiae Member of the SWI/SNF family of DNA-dependent ATPases, plays a role in antagonizing silencing during mating-type switching, contains an N-terminal domain that interacts with Sir4p and a C-terminal SNF2 domain NP_014834.1 692476 D 4932 CDS NP_014835.1 6324766 854364 complement(698769..700568) 1 NC_001147.5 Transporter of thiamine or related compound; shares sequence similarity with Thi7p; Thi72p 700568 THI72 854364 THI72 Saccharomyces cerevisiae Thi72p NP_014835.1 698769 R 4932 CDS NP_878173.1 33438885 1466485 complement(703989..704225) 1 NC_001147.5 Yor192c-cp; Putative protein of unknown function; identified by expression profiling and mass spectrometry 704225 1466485 YOR192C-C Saccharomyces cerevisiae Putative protein of unknown function; identified by expression profiling and mass spectrometry NP_878173.1 703989 R 4932 CDS NP_058185.1 7839201 854365 complement(join(704420..708439,708441..709733)) 1 NC_001147.5 Yor192c-bp; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 709733 854365 YOR192C-B Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_058185.1 704420 R 4932 CDS NP_058186.1 7839200 854366 complement(708417..709733) 1 NC_001147.5 Yor192c-ap; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 709733 854366 YOR192C-A Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_058186.1 708417 R 4932 CDS NP_014836.1 6324767 854368 710447..711577 1 NC_001147.5 Pex27p; Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p 711577 PEX27 854368 PEX27 Saccharomyces cerevisiae Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p NP_014836.1 710447 D 4932 CDS NP_014837.1 6324768 854369 complement(711684..712544) 1 NC_001147.5 Toa1p; TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to largest and second largest subunits of human and Drosophila TFIIA 712544 TOA1 854369 TOA1 Saccharomyces cerevisiae TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to largest and second largest subunits of human and Drosophila TFIIA NP_014837.1 711684 R 4932 CDS NP_014838.1 6324769 854370 712867..715332 1 NC_001147.5 Slk19p; Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate 715332 SLK19 854370 SLK19 Saccharomyces cerevisiae Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate NP_014838.1 712867 D 4932 CDS NP_014839.1 6324770 854371 complement(715594..716838) 1 NC_001147.5 Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase; Lip5p 716838 LIP5 854371 LIP5 Saccharomyces cerevisiae Lip5p NP_014839.1 715594 R 4932 CDS NP_014840.2 99030932 854372 717087..718385 1 NC_001147.5 Putative cysteine protease similar to mammalian caspases, involved in regulation of apoptosis upon hydrogen peroxide treatment; Mca1p 718385 MCA1 854372 MCA1 Saccharomyces cerevisiae Mca1p NP_014840.2 717087 D 4932 CDS NP_014841.1 6324772 854373 complement(718654..720066) 1 NC_001147.5 Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity; Bfr1p 720066 BFR1 854373 BFR1 Saccharomyces cerevisiae Bfr1p NP_014841.1 718654 R 4932 CDS NP_014844.1 6324775 854376 complement(720471..721709) 1 NC_001147.5 Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA; Mrm1p 721709 MRM1 854376 MRM1 Saccharomyces cerevisiae Mrm1p NP_014844.1 720471 R 4932 CDS NP_014845.1 6324776 854377 721947..722609 1 NC_001147.5 Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p; His3p 722609 HIS3 854377 HIS3 Saccharomyces cerevisiae His3p NP_014845.1 721947 D 4932 CDS NP_014847.1 6324778 854379 722912..724726 1 NC_001147.5 Ded1p; ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility 724726 DED1 854379 DED1 Saccharomyces cerevisiae ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility NP_014847.1 722912 D 4932 CDS NP_014848.1 6324779 854380 complement(725565..727235) 1 NC_001147.5 Protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss and severe growth defect in minimal glycerol media; Lrc5p 727235 LRC5 854380 LRC5 Saccharomyces cerevisiae Lrc5p NP_014848.1 725565 R 4932 CDS NP_014849.1 6324780 854381 727513..729645 1 NC_001147.5 Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors; Noc2p 729645 NOC2 854381 NOC2 Saccharomyces cerevisiae Noc2p NP_014849.1 727513 D 4932 CDS NP_014850.1 6324781 854382 complement(730009..733458) 1 NC_001147.5 Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs; Ret1p 733458 RET1 854382 RET1 Saccharomyces cerevisiae Ret1p NP_014850.1 730009 R 4932 CDS NP_014851.1 6324782 854383 733926..736178 1 NC_001147.5 Ptp2p; Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus 736178 PTP2 854383 PTP2 Saccharomyces cerevisiae Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus NP_014851.1 733926 D 4932 CDS NP_014852.1 6324783 854384 complement(736438..737727) 1 NC_001147.5 Npt1p; Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus 737727 NPT1 854384 NPT1 Saccharomyces cerevisiae Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus NP_014852.1 736438 R 4932 CDS NP_014853.1 6324784 854385 738321..738533 1 NC_001147.5 Rpb10p; RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III 738533 RPB10 854385 RPB10 Saccharomyces cerevisiae RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III NP_014853.1 738321 D 4932 CDS NP_014854.2 116006501 854386 complement(738925..741570) 1 NC_001147.5 Mitochondrial GTPase related to dynamin, present in a complex containing Ugo1p and Fzo1p; required for normal morphology of cristae and for stability of Tim11p; homolog of human OPA1 involved in autosomal dominant optic atrophy; Mgm1p 741570 MGM1 854386 MGM1 Saccharomyces cerevisiae Mgm1p NP_014854.2 738925 R 4932 CDS NP_014855.1 6324786 854387 742911..744182 1 NC_001147.5 Ste4p; G protein beta subunit, forms a dimer with Ste18p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste18p to dampen signaling; may recruit Rho1p to the polarized growth site during mating; contains WD40 repeats 744182 STE4 854387 STE4 Saccharomyces cerevisiae G protein beta subunit, forms a dimer with Ste18p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste18p to dampen signaling; may recruit Rho1p to the polarized growth site during mating; contains WD40 repeats NP_014855.1 742911 D 4932 CDS NP_014856.1 6324787 854388 complement(744536..745282) 1 NC_001147.5 Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity; Sas5p 745282 SAS5 854388 SAS5 Saccharomyces cerevisiae Sas5p NP_014856.1 744536 R 4932 CDS NP_014857.1 6324788 854389 complement(745594..746304) 1 NC_001147.5 Yor214cp; Putative protein of unknown function; YOR214C is not an essential gene 746304 854389 YOR214C Saccharomyces cerevisiae Putative protein of unknown function; YOR214C is not an essential gene NP_014857.1 745594 R 4932 CDS NP_014858.1 6324789 854390 complement(746726..747283) 1 NC_001147.5 Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays altered rate of mitochondrial loss and reduced growth rate in minimal glycerol media; Aim41p 747283 AIM41 854390 AIM41 Saccharomyces cerevisiae Aim41p NP_014858.1 746726 R 4932 CDS NP_014859.1 6324790 854391 complement(747526..748980) 1 NC_001147.5 Rud3p; Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1 748980 RUD3 854391 RUD3 Saccharomyces cerevisiae Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1 NP_014859.1 747526 R 4932 CDS NP_014860.1 6324791 854392 749302..751887 1 NC_001147.5 Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; Rfc1p 751887 RFC1 854392 RFC1 Saccharomyces cerevisiae Rfc1p NP_014860.1 749302 D 4932 CDS NP_014862.1 6324793 854394 complement(752215..755010) 1 NC_001147.5 Ste13p; Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor 755010 STE13 854394 STE13 Saccharomyces cerevisiae Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor NP_014862.1 752215 R 4932 CDS NP_014863.1 6324794 854395 755329..756126 1 NC_001147.5 Rcn2p; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS 756126 RCN2 854395 RCN2 Saccharomyces cerevisiae Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS NP_014863.1 755329 D 4932 CDS NP_014864.2 83578107 854396 complement(756477..757559) 1 NC_001147.5 Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling; Mct1p 757559 MCT1 854396 MCT1 Saccharomyces cerevisiae Mct1p NP_014864.2 756477 R 4932 CDS NP_014865.1 6324796 854397 758331..759254 1 NC_001147.5 Odc2p; Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism 759254 ODC2 854397 ODC2 Saccharomyces cerevisiae Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism NP_014865.1 758331 D 4932 CDS NP_014866.1 6324797 854398 759783..760661 1 NC_001147.5 Yor223wp; Putative protein of unknown function 760661 854398 YOR223W Saccharomyces cerevisiae Putative protein of unknown function NP_014866.1 759783 D 4932 CDS NP_014867.1 6324798 854399 complement(760826..761266) 1 NC_001147.5 Rpb8p; RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III 761266 RPB8 854399 RPB8 Saccharomyces cerevisiae RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III NP_014867.1 760826 R 4932 CDS NP_014869.1 6324800 854401 complement(761615..762085) 1 NC_001147.5 Isu2p; Conserved protein of the mitochondrial matrix, required for synthesis of mitochondrial and cytosolic iron-sulfur proteins, performs a scaffolding function in mitochondria during Fe/S cluster assembly; isu1 isu2 double mutant is inviable 762085 ISU2 854401 ISU2 Saccharomyces cerevisiae Conserved protein of the mitochondrial matrix, required for synthesis of mitochondrial and cytosolic iron-sulfur proteins, performs a scaffolding function in mitochondria during Fe/S cluster assembly; isu1 isu2 double mutant is inviable NP_014869.1 761615 R 4932 CDS NP_014870.1 6324801 854402 762826..766566 1 NC_001147.5 Yor227wp; Protein of unknown function that may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 766566 854402 YOR227W Saccharomyces cerevisiae Protein of unknown function that may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_014870.1 762826 D 4932 CDS NP_014871.1 6324802 854403 complement(766870..767778) 1 NC_001147.5 Yor228cp; Protein of unknown function, localized to the mitochondrial outer membrane 767778 854403 YOR228C Saccharomyces cerevisiae Protein of unknown function, localized to the mitochondrial outer membrane NP_014871.1 766870 R 4932 CDS NP_014872.1 6324803 854404 768410..769813 1 NC_001147.5 Wtm2p; Transcriptional repressor involved in regulation of meiosis and silencing; contains WD repeats 769813 WTM2 854404 WTM2 Saccharomyces cerevisiae Transcriptional repressor involved in regulation of meiosis and silencing; contains WD repeats NP_014872.1 768410 D 4932 CDS NP_014873.1 6324804 854405 770801..772114 1 NC_001147.5 Wtm1p; Transcriptional repressor involved in regulation of meiosis and silencing, required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats 772114 WTM1 854405 WTM1 Saccharomyces cerevisiae Transcriptional repressor involved in regulation of meiosis and silencing, required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats NP_014873.1 770801 D 4932 CDS NP_014874.1 6324805 854406 772602..774128 1 NC_001147.5 Mkk1p; Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p 774128 MKK1 854406 MKK1 Saccharomyces cerevisiae Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p NP_014874.1 772602 D 4932 CDS NP_014875.1 6324806 854407 774574..775260 1 NC_001147.5 Protein of the mitochondrial matrix involved in protein import into mitochondria; acts as a cochaperone and a nucleotide release factor for Ssc1p; homolog of E. coli GrpE; Mge1p 775260 MGE1 854407 MGE1 Saccharomyces cerevisiae Mge1p NP_014875.1 774574 D 4932 CDS NP_014876.1 6324807 854408 775847..778249 1 NC_001147.5 Serine/threonine protein kinase that inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; Kin4p 778249 KIN4 854408 KIN4 Saccharomyces cerevisiae Kin4p NP_014876.1 775847 D 4932 CDS NP_014877.1 6324808 854409 complement(join(778556..778860,779388..779406)) 1 NC_001147.5 Rpl33bp; Ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Ap and has similarity to rat L35a; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable 779406 RPL33B 854409 RPL33B Saccharomyces cerevisiae Ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Ap and has similarity to rat L35a; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable NP_014877.1 778556 R 4932 CDS NP_014879.1 6324810 854411 780907..781542 1 NC_001147.5 Dihydrofolate reductase, part of the dTTP biosynthetic pathway, involved in folate metabolism, possibly required for mitochondrial function; Dfr1p 781542 DFR1 854411 DFR1 Saccharomyces cerevisiae Dfr1p NP_014879.1 780907 D 4932 CDS NP_014880.1 6324811 854412 781995..783299 1 NC_001147.5 Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP); Hes1p 783299 HES1 854412 HES1 Saccharomyces cerevisiae Hes1p NP_014880.1 781995 D 4932 CDS NP_014881.2 37362697 854413 783678..784589 1 NC_001147.5 Yor238wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 784589 854413 YOR238W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm NP_014881.2 783678 D 4932 CDS NP_014882.2 9864778 854414 join(784858..785688,785690..786745) 1 NC_001147.5 Nonessential protein that binds actin filaments and localizes to actin patches and cables, has similarity to S-adenosylmethionine (AdoMet)-dependent methyltransferases; Abp140p 786745 ABP140 854414 ABP140 Saccharomyces cerevisiae Abp140p NP_014882.2 784858 D 4932 CDS NP_014884.1 6324815 854415 786996..788642 1 NC_001147.5 Met7p; Folylpolyglutamate synthetase, catalyzes extension of the glutamate chains of the folate coenzymes, required for methionine synthesis and for maintenance of mitochondrial DNA 788642 MET7 854415 MET7 Saccharomyces cerevisiae Folylpolyglutamate synthetase, catalyzes extension of the glutamate chains of the folate coenzymes, required for methionine synthesis and for maintenance of mitochondrial DNA NP_014884.1 786996 D 4932 CDS NP_014885.1 6324816 854416 complement(788743..789858) 1 NC_001147.5 Ssp2p; Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; SSP2 expression is induced midway in meiosis 789858 SSP2 854416 SSP2 Saccharomyces cerevisiae Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; SSP2 expression is induced midway in meiosis NP_014885.1 788743 R 4932 CDS NP_014886.1 6324817 854417 complement(790212..792242) 1 NC_001147.5 Pus7p; Pseudouridine synthase, catalyzes pseudouridylation at position 35 in U2 snRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); Asp(256) mutation abolishes activity; conserved in archaea, some bacteria, and vertebrates 792242 PUS7 854417 PUS7 Saccharomyces cerevisiae Pseudouridine synthase, catalyzes pseudouridylation at position 35 in U2 snRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); Asp(256) mutation abolishes activity; conserved in archaea, some bacteria, and vertebrates NP_014886.1 790212 R 4932 CDS NP_014887.1 6324818 854418 792532..793869 1 NC_001147.5 Histone acetyltransferase catalytic subunit of the native multisubunit complex (NuA4) that acetylates four conserved internal lysines of histone H4 N-terminal tail; required for cell cycle progression; Esa1p 793869 ESA1 854418 ESA1 Saccharomyces cerevisiae Esa1p NP_014887.1 792532 D 4932 CDS NP_014888.1 6324819 854419 complement(794077..795333) 1 NC_001147.5 Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles; Dga1p 795333 DGA1 854419 DGA1 Saccharomyces cerevisiae Dga1p NP_014888.1 794077 R 4932 CDS NP_014889.1 6324820 854420 complement(795802..796794) 1 NC_001147.5 Yor246cp; Protein with similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts 796794 854420 YOR246C Saccharomyces cerevisiae Protein with similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts NP_014889.1 795802 R 4932 CDS NP_014890.1 6324821 854421 797677..798309 1 NC_001147.5 Srl1p; Mannoprotein that exhibits a tight association with the cell wall, required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants 798309 SRL1 854421 SRL1 Saccharomyces cerevisiae Mannoprotein that exhibits a tight association with the cell wall, required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants NP_014890.1 797677 D 4932 CDS NP_014892.1 6324823 854423 complement(798675..800732) 1 NC_001147.5 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; Apc5p 800732 APC5 854423 APC5 Saccharomyces cerevisiae Apc5p NP_014892.1 798675 R 4932 CDS NP_014893.1 6324824 854424 complement(800971..802308) 1 NC_001147.5 Subunit of cleavage factor I (CFI), involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation; Clp1p 802308 CLP1 854424 CLP1 Saccharomyces cerevisiae Clp1p NP_014893.1 800971 R 4932 CDS NP_014894.1 6324825 854425 complement(802551..803465) 1 NC_001147.5 Yor251cp; Putative protein of unknown function with similarity to human thiosulfate sulfurtransferase, an enzyme that catalyzes the transfer of sulfur from thiosulfate to cyanide, forming sulfite and thiocyanate; YOR251C is a non-essential gene 803465 854425 YOR251C Saccharomyces cerevisiae Putative protein of unknown function with similarity to human thiosulfate sulfurtransferase, an enzyme that catalyzes the transfer of sulfur from thiosulfate to cyanide, forming sulfite and thiocyanate; YOR251C is a non-essential gene NP_014894.1 802551 R 4932 CDS NP_014895.2 84626312 854426 803668..804204 1 NC_001147.5 Tma16p; Protein of unknown function that associates with ribosomes 804204 TMA16 854426 TMA16 Saccharomyces cerevisiae Protein of unknown function that associates with ribosomes NP_014895.2 803668 D 4932 CDS NP_014896.1 6324827 854427 804378..804908 1 NC_001147.5 Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing; Nat5p 804908 NAT5 854427 NAT5 Saccharomyces cerevisiae Nat5p NP_014896.1 804378 D 4932 CDS NP_014897.1 6324828 854428 complement(805033..807024) 1 NC_001147.5 Sec63p; Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER 807024 SEC63 854428 SEC63 Saccharomyces cerevisiae Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER NP_014897.1 805033 R 4932 CDS NP_014898.1 6324829 854429 807272..808108 1 NC_001147.5 Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p; Osw1p 808108 OSW1 854429 OSW1 Saccharomyces cerevisiae Osw1p NP_014898.1 807272 D 4932 CDS NP_014899.1 6324830 854430 complement(808254..810683) 1 NC_001147.5 Tre2p; Protein that functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; has similarity to transferrin receptors; inviability of null mutant in systematic studies is due to proximity to CDC31 810683 TRE2 854430 TRE2 Saccharomyces cerevisiae Protein that functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; has similarity to transferrin receptors; inviability of null mutant in systematic studies is due to proximity to CDC31 NP_014899.1 808254 R 4932 CDS NP_014900.1 6324831 854431 811008..811493 1 NC_001147.5 Cdc31p; Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; interacts with Kar1p 811493 CDC31 854431 CDC31 Saccharomyces cerevisiae Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; interacts with Kar1p NP_014900.1 811008 D 4932 CDS NP_014901.1 6324832 854432 811671..812324 1 NC_001147.5 Member of the third branch of the histidine triad (HIT) superfamily of nucleotide-binding proteins; similar to Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia; Hnt3p 812324 HNT3 854432 HNT3 Saccharomyces cerevisiae Hnt3p NP_014901.1 811671 D 4932 CDS NP_014902.1 6324833 854433 complement(812395..813708) 1 NC_001147.5 Rpt4p; One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for spindle pole body duplication; localized mainly to the nucleus throughout the cell cycle 813708 RPT4 854433 RPT4 Saccharomyces cerevisiae One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for spindle pole body duplication; localized mainly to the nucleus throughout the cell cycle NP_014902.1 812395 R 4932 CDS NP_014903.1 6324834 854434 813984..815720 1 NC_001147.5 Gcd1p; Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression 815720 GCD1 854434 GCD1 Saccharomyces cerevisiae Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression NP_014903.1 813984 D 4932 CDS NP_014904.1 6324835 854435 complement(815915..816931) 1 NC_001147.5 Rpn8p; Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p 816931 RPN8 854435 RPN8 Saccharomyces cerevisiae Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p NP_014904.1 815915 R 4932 CDS NP_014905.1 6324836 854436 817291..818334 1 NC_001147.5 Yor262wp; Cytoplasmic protein of unknown function; essential gene with similarity to YLR243W; contains an ATP/GTP binding site motif 818334 854436 YOR262W Saccharomyces cerevisiae Cytoplasmic protein of unknown function; essential gene with similarity to YLR243W; contains an ATP/GTP binding site motif NP_014905.1 817291 D 4932 CDS NP_014907.1 6324837 854437 818865..820157 1 NC_001147.5 Dse3p; Daughter cell-specific protein, may help establish daughter fate 820157 DSE3 854437 DSE3 Saccharomyces cerevisiae Daughter cell-specific protein, may help establish daughter fate NP_014907.1 818865 D 4932 CDS NP_014908.1 6324839 854439 820453..820773 1 NC_001147.5 Rbl2p; Protein involved in microtubule morphogenesis, required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin; similar to mouse beta-tubulin cofactor A 820773 RBL2 854439 RBL2 Saccharomyces cerevisiae Protein involved in microtubule morphogenesis, required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin; similar to mouse beta-tubulin cofactor A NP_014908.1 820453 D 4932 CDS NP_014909.1 6324840 854440 821022..822293 1 NC_001147.5 Pnt1p; Mitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine 822293 PNT1 854440 PNT1 Saccharomyces cerevisiae Mitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine NP_014909.1 821022 D 4932 CDS NP_014910.1 6324841 854441 complement(822587..824866) 1 NC_001147.5 Protein kinase implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; Hrk1p 824866 HRK1 854441 HRK1 Saccharomyces cerevisiae Hrk1p NP_014910.1 822587 R 4932 CDS NP_014911.1 6324842 854442 complement(825533..825931) 1 NC_001147.5 Yor268cp; Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene 825931 854442 YOR268C Saccharomyces cerevisiae Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene NP_014911.1 825533 R 4932 CDS NP_014912.1 6324843 854443 826384..827868 1 NC_001147.5 Protein involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; synthetic lethal with bni1; homolog of human LIS1; Pac1p 827868 PAC1 854443 PAC1 Saccharomyces cerevisiae Pac1p NP_014912.1 826384 D 4932 CDS NP_014913.1 6324844 854444 complement(828051..830573) 1 NC_001147.5 Vph1p; Subunit a of vacuolar-ATPase V0 domain, one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes 830573 VPH1 854444 VPH1 Saccharomyces cerevisiae Subunit a of vacuolar-ATPase V0 domain, one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes NP_014913.1 828051 R 4932 CDS NP_014914.1 6324845 854445 complement(831058..832041) 1 NC_001147.5 Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis; Fsf1p 832041 FSF1 854445 FSF1 Saccharomyces cerevisiae Fsf1p NP_014914.1 831058 R 4932 CDS NP_014915.1 6324846 854446 832812..834194 1 NC_001147.5 Ytm1p; Constituent of 66S pre-ribosomal particles, required for maturation of the large ribosomal subunit 834194 YTM1 854446 YTM1 Saccharomyces cerevisiae Constituent of 66S pre-ribosomal particles, required for maturation of the large ribosomal subunit NP_014915.1 832812 D 4932 CDS NP_014916.1 6324847 854447 complement(834451..836430) 1 NC_001147.5 Tpo4p; Polyamine transport protein, recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane; member of the major facilitator superfamily 836430 TPO4 854447 TPO4 Saccharomyces cerevisiae Polyamine transport protein, recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane; member of the major facilitator superfamily NP_014916.1 834451 R 4932 CDS NP_014917.1 6324848 854448 837673..838959 1 NC_001147.5 Mod5p; Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase, required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms 838959 MOD5 854448 MOD5 Saccharomyces cerevisiae Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase, required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms NP_014917.1 837673 D 4932 CDS NP_014918.1 6324849 854449 complement(839083..841068) 1 NC_001147.5 Rim20p; Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation 841068 RIM20 854449 RIM20 Saccharomyces cerevisiae Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation NP_014918.1 839083 R 4932 CDS NP_014919.1 6324850 854450 841332..841817 1 NC_001147.5 Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E; Caf20p 841817 CAF20 854450 CAF20 Saccharomyces cerevisiae Caf20p NP_014919.1 841332 D 4932 CDS NP_014921.1 6324852 854452 842816..843643 1 NC_001147.5 Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in the heme biosynthetic pathway; Hem4p 843643 HEM4 854452 HEM4 Saccharomyces cerevisiae Hem4p NP_014921.1 842816 D 4932 CDS NP_014922.1 6324853 854453 complement(843697..844629) 1 NC_001147.5 Rfm1p; DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance 844629 RFM1 854453 RFM1 Saccharomyces cerevisiae DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance NP_014922.1 843697 R 4932 CDS NP_014923.1 6324854 854454 complement(844991..845791) 1 NC_001147.5 Serine hydrolase; sequence is similar to Fsh1p and Fsh2p; Fsh3p 845791 FSH3 854454 FSH3 Saccharomyces cerevisiae Fsh3p NP_014923.1 844991 R 4932 CDS NP_014924.1 6324856 854456 complement(846268..847128) 1 NC_001147.5 Plp2p; Essential protein with similarity to phosducins, which are G-protein regulators; lethality of null mutation is functionally complemented by expression of mouse phosducin-like protein MgcPhLP 847128 PLP2 854456 PLP2 Saccharomyces cerevisiae Essential protein with similarity to phosducins, which are G-protein regulators; lethality of null mutation is functionally complemented by expression of mouse phosducin-like protein MgcPhLP NP_014924.1 846268 R 4932 CDS NP_014926.1 6324857 854457 847452..848144 1 NC_001147.5 Yor283wp; Putative protein of unknown function with some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene 848144 854457 YOR283W Saccharomyces cerevisiae Putative protein of unknown function with some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene NP_014926.1 847452 D 4932 CDS NP_014927.1 6324858 854458 848477..849208 1 NC_001147.5 Hua2p; Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly 849208 HUA2 854458 HUA2 Saccharomyces cerevisiae Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly NP_014927.1 848477 D 4932 CDS NP_014928.1 6324859 854459 849634..850053 1 NC_001147.5 Yor285wp; Protein of unknown function, localized to the mitochondrial outer membrane 850053 854459 YOR285W Saccharomyces cerevisiae Protein of unknown function, localized to the mitochondrial outer membrane NP_014928.1 849634 D 4932 CDS NP_014929.1 6324860 854460 850279..850728 1 NC_001147.5 Protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays increased frequency of mitochondrial genome loss and reduced growth rate in minimal glycerol media; Aim42p 850728 AIM42 854460 AIM42 Saccharomyces cerevisiae Aim42p NP_014929.1 850279 D 4932 CDS NP_014930.1 6324861 854461 complement(850936..851838) 1 NC_001147.5 Yor287cp; Putative protein of unknown function; may play a role in the ribosome and rRNA biosynthesis based on expression profiles and mutant phenotype 851838 854461 YOR287C Saccharomyces cerevisiae Putative protein of unknown function; may play a role in the ribosome and rRNA biosynthesis based on expression profiles and mutant phenotype NP_014930.1 850936 R 4932 CDS NP_014931.1 6324862 854462 complement(852120..853076) 1 NC_001147.5 Mpd1p; Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation 853076 MPD1 854462 MPD1 Saccharomyces cerevisiae Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation NP_014931.1 852120 R 4932 CDS NP_014932.1 6324863 854463 853356..854111 1 NC_001147.5 Yor289wp; Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus 854111 854463 YOR289W Saccharomyces cerevisiae Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus NP_014932.1 853356 D 4932 CDS NP_014933.1 6324864 854465 complement(855146..860257) 1 NC_001147.5 Snf2p; Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p 860257 SNF2 854465 SNF2 Saccharomyces cerevisiae Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p NP_014933.1 855146 R 4932 CDS NP_014934.1 6324865 854466 861174..865592 1 NC_001147.5 Yor291wp; Putative protein of unknown function; shares sequence similarity with the type V P-type ATPase Spf1p; YOR291W is not an essential protein 865592 854466 YOR291W Saccharomyces cerevisiae Putative protein of unknown function; shares sequence similarity with the type V P-type ATPase Spf1p; YOR291W is not an essential protein NP_014934.1 861174 D 4932 CDS NP_014935.1 6324866 854467 complement(865652..866581) 1 NC_001147.5 Yor292cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene 866581 854467 YOR292C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene NP_014935.1 865652 R 4932 CDS NP_014936.1 6324867 854468 join(867097..867148,867586..867851) 1 NC_001147.5 Rps10ap; Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Bp and has similarity to rat ribosomal protein S10 867851 RPS10A 854468 RPS10A Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Bp and has similarity to rat ribosomal protein S10 NP_014936.1 867097 D 4932 CDS NP_878174.1 33438886 1466486 complement(867997..868146) 1 NC_001147.5 Yor293c-ap; Identified by expression profiling and mass spectrometry 868146 1466486 YOR293C-A Saccharomyces cerevisiae Identified by expression profiling and mass spectrometry NP_878174.1 867997 R 4932 CDS NP_014937.1 6324868 854469 868339..868950 1 NC_001147.5 Rrs1p; Essential protein that binds ribosomal protein L11 and is required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; mouse homolog shows altered expression in Huntington's disease model mice 868950 RRS1 854469 RRS1 Saccharomyces cerevisiae Essential protein that binds ribosomal protein L11 and is required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; mouse homolog shows altered expression in Huntington's disease model mice NP_014937.1 868339 D 4932 CDS NP_014938.1 6324869 854470 869207..869893 1 NC_001147.5 Uaf30p; Subunit of UAF (upstream activation factor), which is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate 869893 UAF30 854470 UAF30 Saccharomyces cerevisiae Subunit of UAF (upstream activation factor), which is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate NP_014938.1 869207 D 4932 CDS NP_014939.1 6324870 854471 870201..874070 1 NC_001147.5 Yor296wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene 874070 854471 YOR296W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene NP_014939.1 870201 D 4932 CDS NP_014940.1 6324871 854472 complement(874742..875320) 1 NC_001147.5 Tim18p; Component of the mitochondrial Tim54p-Tim22p complex involved in insertion of polytopic proteins into the inner membrane; may function to stabilize the complex 875320 TIM18 854472 TIM18 Saccharomyces cerevisiae Component of the mitochondrial Tim54p-Tim22p complex involved in insertion of polytopic proteins into the inner membrane; may function to stabilize the complex NP_014940.1 874742 R 4932 CDS NP_014941.1 6324872 854473 875598..877037 1 NC_001147.5 Protein of unknown function involved in the organization of the outer spore wall layers; has similarity to the tafazzins superfamily of acyltransferases; Mum3p 877037 MUM3 854473 MUM3 Saccharomyces cerevisiae Mum3p NP_014941.1 875598 D 4932 CDS NP_014942.2 42742310 854474 complement(877229..877684) 1 NC_001147.5 Transcriptional coactivator that bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; Mbf1p 877684 MBF1 854474 MBF1 Saccharomyces cerevisiae Mbf1p NP_014942.2 877229 R 4932 CDS NP_014943.1 6324874 854475 878433..880673 1 NC_001147.5 Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; Bud7p 880673 BUD7 854475 BUD7 Saccharomyces cerevisiae Bud7p NP_014943.1 878433 D 4932 CDS NP_014945.1 6324876 854477 880963..882270 1 NC_001147.5 Rax1p; Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily 882270 RAX1 854477 RAX1 Saccharomyces cerevisiae Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily NP_014945.1 880963 D 4932 CDS NP_014946.1 6324877 854478 882763..882840 1 NC_001147.5 Yor302wp; CPA1 uORF , Arginine attenuator peptide, regulates translation of the CPA1 mRNA 882840 854478 YOR302W Saccharomyces cerevisiae CPA1 uORF , Arginine attenuator peptide, regulates translation of the CPA1 mRNA NP_014946.1 882763 D 4932 CDS NP_014947.1 6324878 854479 882897..884132 1 NC_001147.5 Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader; Cpa1p 884132 CPA1 854479 CPA1 Saccharomyces cerevisiae Cpa1p NP_014947.1 882897 D 4932 CDS NP_014948.1 6324879 854480 884512..887874 1 NC_001147.5 Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth; Isw2p 887874 ISW2 854480 ISW2 Saccharomyces cerevisiae Isw2p NP_014948.1 884512 D 4932 CDS NP_014949.1 6324880 854481 complement(888518..888748) 1 NC_001147.5 Yor304c-ap; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck 888748 854481 YOR304C-A Saccharomyces cerevisiae Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck NP_014949.1 888518 R 4932 CDS NP_014950.1 6324881 854482 889020..889748 1 NC_001147.5 Yor305wp; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene 889748 854482 YOR305W Saccharomyces cerevisiae Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene NP_014950.1 889020 D 4932 CDS NP_014951.1 6324882 854483 complement(889865..891430) 1 NC_001147.5 Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport; Mch5p 891430 MCH5 854483 MCH5 Saccharomyces cerevisiae Mch5p NP_014951.1 889865 R 4932 CDS NP_014952.1 6324883 854484 complement(892728..894089) 1 NC_001147.5 Sly41p; Protein involved in ER-to-Golgi transport 894089 SLY41 854484 SLY41 Saccharomyces cerevisiae Protein involved in ER-to-Golgi transport NP_014952.1 892728 R 4932 CDS NP_014953.1 6324884 854485 complement(894621..896384) 1 NC_001147.5 Snu66p; Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; has homology to human SART-1 and to an S. pombe protein; snu66 null mutation confers cold-sensitivity but is not lethal at normal growth temperatures 896384 SNU66 854485 SNU66 Saccharomyces cerevisiae Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; has homology to human SART-1 and to an S. pombe protein; snu66 null mutation confers cold-sensitivity but is not lethal at normal growth temperatures NP_014953.1 894621 R 4932 CDS NP_014955.1 6324886 854487 complement(896822..898357) 1 NC_001147.5 Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA; Nop58p 898357 NOP58 854487 NOP58 Saccharomyces cerevisiae Nop58p NP_014955.1 896822 R 4932 CDS NP_014956.1 6324887 854488 complement(899053..899925) 1 NC_001147.5 Hsd1p; Endoplasmic reticulum (ER)-resident membrane protein, overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation 899925 HSD1 854488 HSD1 Saccharomyces cerevisiae Endoplasmic reticulum (ER)-resident membrane protein, overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation NP_014956.1 899053 R 4932 CDS NP_014957.2 154200011 854489 complement(join(900247..900764,901191)) 1 NC_001147.5 Rpl20bp; Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Ap and has similarity to rat L18a ribosomal protein 901191 RPL20B 854489 RPL20B Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Ap and has similarity to rat L18a ribosomal protein NP_014957.2 900247 R 4932 CDS NP_014958.1 6324889 854490 complement(901855..902871) 1 NC_001147.5 Sps4p; Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage 902871 SPS4 854490 SPS4 Saccharomyces cerevisiae Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage NP_014958.1 901855 R 4932 CDS NP_014960.1 6324891 854493 904757..905797 1 NC_001147.5 Sfg1p; Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate 905797 SFG1 854493 SFG1 Saccharomyces cerevisiae Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate NP_014960.1 904757 D 4932 CDS NP_014961.1 6324892 854494 complement(906233..907552) 1 NC_001147.5 Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium; Cot1p 907552 COT1 854494 COT1 Saccharomyces cerevisiae Cot1p NP_014961.1 906233 R 4932 CDS NP_878175.1 33438887 1466487 complement(907723..907932) 1 NC_001147.5 Yor316c-ap; Putative protein of unknown function; identified by fungal homology and RT-PCR 907932 1466487 YOR316C-A Saccharomyces cerevisiae Putative protein of unknown function; identified by fungal homology and RT-PCR NP_878175.1 907723 R 4932 CDS NP_014962.1 6324893 854495 909340..911442 1 NC_001147.5 Long chain fatty acyl-CoA synthetase with a preference for C12:0-C16:0 fatty acids; involved in the activation of imported fatty acids; localized to both lipid particles and mitochondrial outer membrane; essential for stationary phase; Faa1p 911442 FAA1 854495 FAA1 Saccharomyces cerevisiae Faa1p NP_014962.1 909340 D 4932 CDS NP_014964.1 6324895 854497 912819..913460 1 NC_001147.5 U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM); Hsh49p 913460 HSH49 854497 HSH49 Saccharomyces cerevisiae Hsh49p NP_014964.1 912819 D 4932 CDS NP_014965.1 6324896 854498 complement(913616..915091) 1 NC_001147.5 N-acetylglucosaminyltransferase capable of modification of N-linked glycans in the Golgi apparatus; Gnt1p 915091 GNT1 854498 GNT1 Saccharomyces cerevisiae Gnt1p NP_014965.1 913616 R 4932 CDS NP_014966.1 6324897 854499 916027..918288 1 NC_001147.5 Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; target for new antifungals; Pmt3p 918288 PMT3 854499 PMT3 Saccharomyces cerevisiae Pmt3p NP_014966.1 916027 D 4932 CDS NP_014967.1 6324898 854500 complement(918603..921059) 1 NC_001147.5 Protein of unknown function involved in maintenance of proper telomere length; null mutant shows a reduced affinity for the alcian blue dye suggesting a decreased net negative charge of the cell surface; Ldb19p 921059 LDB19 854500 LDB19 Saccharomyces cerevisiae Ldb19p NP_014967.1 918603 R 4932 CDS NP_014968.1 6324899 854501 complement(921532..922902) 1 NC_001147.5 Pro2p; Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis 922902 PRO2 854501 PRO2 Saccharomyces cerevisiae Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis NP_014968.1 921532 R 4932 CDS NP_014969.1 6324901 854503 complement(923229..925037) 1 NC_001147.5 Tail-anchored endoplasmic reticulum membrane protein that is a substrate of the phosphatase calcineurin, interacts with homolog Frt2p, promotes cell growth in conditions of high Na+, alkaline pH, and cell wall stress; Frt1p 925037 FRT1 854503 FRT1 Saccharomyces cerevisiae Frt1p NP_014969.1 923229 R 4932 CDS NP_014971.1 6324902 854504 925718..930442 1 NC_001147.5 One of two type V myosin motors (along with MYO4) involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle; Myo2p 930442 MYO2 854504 MYO2 Saccharomyces cerevisiae Myo2p NP_014971.1 925718 D 4932 CDS NP_014972.1 6324903 854505 complement(930731..931078) 1 NC_001147.5 Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; Snc2p 931078 SNC2 854505 SNC2 Saccharomyces cerevisiae Snc2p NP_014972.1 930731 R 4932 CDS NP_014973.1 6324904 854506 931800..936494 1 NC_001147.5 Pdr10p; ATP-binding cassette (ABC) transporter, multidrug transporter involved in the pleiotropic drug resistance network; regulated by Pdr1p and Pdr3p 936494 PDR10 854506 PDR10 Saccharomyces cerevisiae ATP-binding cassette (ABC) transporter, multidrug transporter involved in the pleiotropic drug resistance network; regulated by Pdr1p and Pdr3p NP_014973.1 931800 D 4932 CDS NP_014974.1 6324905 854507 complement(936728..939346) 1 NC_001147.5 Scd5p; Protein required for normal cortical actin organization and endocytosis; multicopy suppressor of clathrin deficiency; acts as a targeting subunit for protein phosphatase type 1 939346 SCD5 854507 SCD5 Saccharomyces cerevisiae Protein required for normal cortical actin organization and endocytosis; multicopy suppressor of clathrin deficiency; acts as a targeting subunit for protein phosphatase type 1 NP_014974.1 936728 R 4932 CDS NP_014975.2 83578108 854508 complement(939618..943382) 1 NC_001147.5 Mip1p; Catalytic subunit of the mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome. 943382 MIP1 854508 MIP1 Saccharomyces cerevisiae Catalytic subunit of the mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome. NP_014975.2 939618 R 4932 CDS NP_014977.1 6324907 854509 943653..944354 1 NC_001147.5 Vma4p; Subunit E of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane 944354 VMA4 854509 VMA4 Saccharomyces cerevisiae Subunit E of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane NP_014977.1 943653 D 4932 CDS NP_014979.1 6324909 854511 944593..946005 1 NC_001147.5 Mrs2p; Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns 946005 MRS2 854511 MRS2 Saccharomyces cerevisiae Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns NP_014979.1 944593 D 4932 CDS NP_014980.1 6324911 854513 complement(946230..949106) 1 NC_001147.5 Cytoplasmic alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog; Ala1p 949106 ALA1 854513 ALA1 Saccharomyces cerevisiae Ala1p NP_014980.1 946230 R 4932 CDS NP_014981.1 6324912 854514 949770..953867 1 NC_001147.5 Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects; Kre5p 953867 KRE5 854514 KRE5 Saccharomyces cerevisiae Kre5p NP_014981.1 949770 D 4932 CDS NP_014982.1 6324913 854515 954341..956620 1 NC_001147.5 Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein; Tea1p 956620 TEA1 854515 TEA1 Saccharomyces cerevisiae Tea1p NP_014982.1 954341 D 4932 CDS NP_014983.1 6324914 854516 956895..957986 1 NC_001147.5 Yor338wp; Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen 957986 854516 YOR338W Saccharomyces cerevisiae Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen NP_014983.1 956895 D 4932 CDS NP_014984.1 6324915 854517 complement(958359..958829) 1 NC_001147.5 Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2; Ubc11p 958829 UBC11 854517 UBC11 Saccharomyces cerevisiae Ubc11p NP_014984.1 958359 R 4932 CDS NP_014985.1 6324916 854518 complement(959199..960179) 1 NC_001147.5 Rpa43p; RNA polymerase I subunit A43 960179 RPA43 854518 RPA43 Saccharomyces cerevisiae RNA polymerase I subunit A43 NP_014985.1 959199 R 4932 CDS NP_014986.1 6324917 854519 960984..965978 1 NC_001147.5 Rpa190p; RNA polymerase I subunit; largest subunit of RNA polymerase I 965978 RPA190 854519 RPA190 Saccharomyces cerevisiae RNA polymerase I subunit; largest subunit of RNA polymerase I NP_014986.1 960984 D 4932 CDS NP_014987.1 6324918 854520 complement(966663..967622) 1 NC_001147.5 Yor342cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus 967622 854520 YOR342C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus NP_014987.1 966663 R 4932 CDS NP_620389.1 20336770 854523 join(970575..971868,971870..975888) 1 NC_001147.5 Yor343w-bp; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 975888 854523 YOR343W-B Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_620389.1 970575 D 4932 CDS NP_620390.1 20336769 854522 970575..971891 1 NC_001147.5 Yor343w-ap; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 971891 854522 YOR343W-A Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_620390.1 970575 D 4932 CDS NP_014989.1 6324920 854525 complement(977191..978066) 1 NC_001147.5 Tye7p; Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression 978066 TYE7 854525 TYE7 Saccharomyces cerevisiae Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression NP_014989.1 977191 R 4932 CDS NP_014991.1 6324921 854527 981825..984782 1 NC_001147.5 Rev1p; Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA 984782 REV1 854527 REV1 Saccharomyces cerevisiae Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA NP_014991.1 981825 D 4932 CDS NP_014992.1 6324923 854529 complement(984939..986459) 1 NC_001147.5 Pyruvate kinase that appears to be modulated by phosphorylation; PYK2 transcription is repressed by glucose, and Pyk2p may be active under low glycolytic flux; Pyk2p 986459 PYK2 854529 PYK2 Saccharomyces cerevisiae Pyk2p NP_014992.1 984939 R 4932 CDS NP_014993.1 6324924 854530 complement(986896..988779) 1 NC_001147.5 Put4p; Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells 988779 PUT4 854530 PUT4 Saccharomyces cerevisiae Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells NP_014993.1 986896 R 4932 CDS NP_014994.1 6324925 854531 989786..992830 1 NC_001147.5 Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; Cin1p 992830 CIN1 854531 CIN1 Saccharomyces cerevisiae Cin1p NP_014994.1 989786 D 4932 CDS NP_014995.1 6324926 854532 complement(992861..994852) 1 NC_001147.5 Mne1p; Mitochondrial protein similar to Lucilia illustris mitochondrial cytochrome oxidase 994852 MNE1 854532 MNE1 Saccharomyces cerevisiae Mitochondrial protein similar to Lucilia illustris mitochondrial cytochrome oxidase NP_014995.1 992861 R 4932 CDS NP_014996.1 6324927 854533 complement(995015..996508) 1 NC_001147.5 Mek1p; Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids 996508 MEK1 854533 MEK1 Saccharomyces cerevisiae Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids NP_014996.1 995015 R 4932 CDS NP_014997.1 6324928 854534 997210..998241 1 NC_001147.5 Yor352wp; Putative protein of unknown function; expression levels regulated by Arg5,6p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus 998241 854534 YOR352W Saccharomyces cerevisiae Putative protein of unknown function; expression levels regulated by Arg5,6p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus NP_014997.1 997210 D 4932 CDS NP_014998.1 6324929 854535 complement(998450..1000825) 1 NC_001147.5 Sog2p; Key component of the RAM signaling network, required for proper cell morphogenesis and cell separation after mitosis 1000825 SOG2 854535 SOG2 Saccharomyces cerevisiae Key component of the RAM signaling network, required for proper cell morphogenesis and cell separation after mitosis NP_014998.1 998450 R 4932 CDS NP_014999.1 6324930 854536 complement(1001144..1003222) 1 NC_001147.5 Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Msc6p 1003222 MSC6 854536 MSC6 Saccharomyces cerevisiae Msc6p NP_014999.1 1001144 R 4932 CDS NP_015000.1 6324931 854537 1005135..1006703 1 NC_001147.5 Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Gds1p 1006703 GDS1 854537 GDS1 Saccharomyces cerevisiae Gds1p NP_015000.1 1005135 D 4932 CDS NP_015001.1 6324932 854538 1007219..1009114 1 NC_001147.5 Yor356wp; Mitochondrial protein with similarity to flavoprotein-type oxidoreductases; found in a large supramolecular complex with other mitochondrial dehydrogenases 1009114 854538 YOR356W Saccharomyces cerevisiae Mitochondrial protein with similarity to flavoprotein-type oxidoreductases; found in a large supramolecular complex with other mitochondrial dehydrogenases NP_015001.1 1007219 D 4932 CDS NP_015002.1 6324933 854539 complement(1009222..1009710) 1 NC_001147.5 Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p; Snx3p 1009710 SNX3 854539 SNX3 Saccharomyces cerevisiae Snx3p NP_015002.1 1009222 R 4932 CDS NP_015003.1 6324934 854540 1010159..1010887 1 NC_001147.5 Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex; Hap5p 1010887 HAP5 854540 HAP5 Saccharomyces cerevisiae Hap5p NP_015003.1 1010159 D 4932 CDS NP_015004.1 6324935 854541 1011187..1012758 1 NC_001147.5 Vts1p; Post-transcriptional gene regulator, RNA-binding protein containing a SAM domain; shows genetic interactions with Vti1p, which is a v-SNARE involved in cis-Golgi membrane traffic 1012758 VTS1 854541 VTS1 Saccharomyces cerevisiae Post-transcriptional gene regulator, RNA-binding protein containing a SAM domain; shows genetic interactions with Vti1p, which is a v-SNARE involved in cis-Golgi membrane traffic NP_015004.1 1011187 D 4932 CDS NP_015005.1 6324936 854542 complement(1013239..1014819) 1 NC_001147.5 Pde2p; High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon 1014819 PDE2 854542 PDE2 Saccharomyces cerevisiae High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon NP_015005.1 1013239 R 4932 CDS NP_015006.1 6324937 854543 complement(1015359..1017650) 1 NC_001147.5 Subunit of the core complex of translation initiation factor 3(eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes; Prt1p 1017650 PRT1 854543 PRT1 Saccharomyces cerevisiae Prt1p NP_015006.1 1015359 R 4932 CDS NP_015007.1 6324938 854544 complement(1017878..1018744) 1 NC_001147.5 Pre10p; 20S proteasome alpha-type subunit 1018744 PRE10 854544 PRE10 Saccharomyces cerevisiae 20S proteasome alpha-type subunit NP_015007.1 1017878 R 4932 CDS NP_015008.1 6324939 854545 complement(1020220..1023210) 1 NC_001147.5 Pip2p; Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes 1023210 PIP2 854545 PIP2 Saccharomyces cerevisiae Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes NP_015008.1 1020220 R 4932 CDS NP_015010.1 6324942 854548 complement(1023459..1025570) 1 NC_001147.5 Yor365cp; Putative protein of unknown function; YOR365C is not an essential protein 1025570 854548 YOR365C Saccharomyces cerevisiae Putative protein of unknown function; YOR365C is not an essential protein NP_015010.1 1023459 R 4932 CDS NP_015012.1 6324943 854549 1026005..1026607 1 NC_001147.5 Scp1p; Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin 1026607 SCP1 854549 SCP1 Saccharomyces cerevisiae Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin NP_015012.1 1026005 D 4932 CDS NP_015013.1 6324944 854550 1026841..1028046 1 NC_001147.5 Rad17p; Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins 1028046 RAD17 854550 RAD17 Saccharomyces cerevisiae Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins NP_015013.1 1026841 D 4932 CDS NP_015014.1 6324945 854551 complement(1028192..1028623) 1 NC_001147.5 Rps12p; Protein component of the small (40S) ribosomal subunit; has similarity to rat ribosomal protein S12 1028623 RPS12 854551 RPS12 Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit; has similarity to rat ribosomal protein S12 NP_015014.1 1028192 R 4932 CDS NP_015015.1 6324946 854552 complement(1029181..1030992) 1 NC_001147.5 Rab escort protein, forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p); Mrs6p 1030992 MRS6 854552 MRS6 Saccharomyces cerevisiae Mrs6p NP_015015.1 1029181 R 4932 CDS NP_015016.1 6324947 854553 complement(1031487..1034180) 1 NC_001147.5 Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb2p; Gpb1p 1034180 GPB1 854553 GPB1 Saccharomyces cerevisiae Gpb1p NP_015016.1 1031487 R 4932 CDS NP_015017.1 6324948 854554 complement(1034805..1036469) 1 NC_001147.5 Transcriptional activator essential for nuclear division; localized to the nucleus; essential component of the mechanism that activates the expression of a set of late-S-phase-specific genes; Ndd1p 1036469 NDD1 854554 NDD1 Saccharomyces cerevisiae Ndd1p NP_015017.1 1034805 R 4932 CDS NP_015018.1 6324949 854555 1036832..1039387 1 NC_001147.5 Nud1p; Component of the spindle pole body outer plaque, required for exit from mitosis 1039387 NUD1 854555 NUD1 Saccharomyces cerevisiae Component of the spindle pole body outer plaque, required for exit from mitosis NP_015018.1 1036832 D 4932 CDS NP_015019.1 6324950 854556 1039838..1041397 1 NC_001147.5 Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed; Ald4p 1041397 ALD4 854556 ALD4 Saccharomyces cerevisiae Ald4p NP_015019.1 1039838 D 4932 CDS NP_015020.1 6324951 854557 complement(1041676..1043040) 1 NC_001147.5 NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources; Gdh1p 1043040 GDH1 854557 GDH1 Saccharomyces cerevisiae Gdh1p NP_015020.1 1041676 R 4932 CDS NP_878176.1 33438888 1466488 1045194..1045349 1 NC_001147.5 Yor376w-ap; Putative protein of unknown function; identified by fungal homology and RT-PCR 1045349 1466488 YOR376W-A Saccharomyces cerevisiae Putative protein of unknown function; identified by fungal homology and RT-PCR NP_878176.1 1045194 D 4932 CDS NP_015022.1 6324953 854559 1046224..1047801 1 NC_001147.5 Atf1p; Alcohol acetyltransferase with potential roles in lipid and sterol metabolism; responsible for the major part of volatile acetate ester production during fermentation 1047801 ATF1 854559 ATF1 Saccharomyces cerevisiae Alcohol acetyltransferase with potential roles in lipid and sterol metabolism; responsible for the major part of volatile acetate ester production during fermentation NP_015022.1 1046224 D 4932 CDS NP_015023.1 6324954 854560 1049509..1051056 1 NC_001147.5 Yor378wp; Putative protein of unknown function; belongs to the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene 1051056 854560 YOR378W Saccharomyces cerevisiae Putative protein of unknown function; belongs to the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene NP_015023.1 1049509 D 4932 CDS NP_015025.1 6324956 854562 1051288..1052928 1 NC_001147.5 Transcriptional repressor involved in the control of multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins; Rdr1p 1052928 RDR1 854562 RDR1 Saccharomyces cerevisiae Rdr1p NP_015025.1 1051288 D 4932 CDS NP_015026.1 6324957 854563 1055543..1057678 1 NC_001147.5 Fre3p; Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels 1057678 FRE3 854563 FRE3 Saccharomyces cerevisiae Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels NP_015026.1 1055543 D 4932 CDS NP_878177.1 33438889 1466489 1058421..1058588 1 NC_001147.5 Yor381w-ap; Putative protein of unknown function; identified by fungal homology and RT-PCR 1058588 1466489 YOR381W-A Saccharomyces cerevisiae Putative protein of unknown function; identified by fungal homology and RT-PCR NP_878177.1 1058421 D 4932 CDS NP_015027.1 6324958 854564 1059529..1059990 1 NC_001147.5 Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall; Fit2p 1059990 FIT2 854564 FIT2 Saccharomyces cerevisiae Fit2p NP_015027.1 1059529 D 4932 CDS NP_015028.1 6324959 854565 complement(1060439..1061053) 1 NC_001147.5 Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall; Fit3p 1061053 FIT3 854565 FIT3 Saccharomyces cerevisiae Fit3p NP_015028.1 1060439 R 4932 CDS NP_015029.1 6324960 854566 1061562..1063646 1 NC_001147.5 Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Fre5p 1063646 FRE5 854566 FRE5 Saccharomyces cerevisiae Fre5p NP_015029.1 1061562 D 4932 CDS NP_015030.1 6324961 854567 1065041..1065913 1 NC_001147.5 Yor385wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene 1065913 854567 YOR385W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene NP_015030.1 1065041 D 4932 CDS NP_015031.1 6324962 854568 1066837..1068534 1 NC_001147.5 Phr1p; DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p 1068534 PHR1 854568 PHR1 Saccharomyces cerevisiae DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p NP_015031.1 1066837 D 4932 CDS NP_015032.1 6324963 854569 complement(1069619..1070239) 1 NC_001147.5 Yor387cp; Putative protein of unknown function; regulated by the metal-responsive Aft1p transcription factor; highly inducible in zinc-depleted conditions; localizes to the soluble fraction 1070239 854569 YOR387C Saccharomyces cerevisiae Putative protein of unknown function; regulated by the metal-responsive Aft1p transcription factor; highly inducible in zinc-depleted conditions; localizes to the soluble fraction NP_015032.1 1069619 R 4932 CDS NP_015033.1 6324964 854570 complement(1071791..1072921) 1 NC_001147.5 NAD(+)-dependent formate dehydrogenase, may protect cells from exogenous formate; Fdh1p 1072921 FDH1 854570 FDH1 Saccharomyces cerevisiae Fdh1p NP_015033.1 1071791 R 4932 CDS NP_015034.1 6324965 854571 1074211..1076085 1 NC_001147.5 Yor389wp; Putative protein of unknown function; expression regulated by copper levels 1076085 854571 YOR389W Saccharomyces cerevisiae Putative protein of unknown function; expression regulated by copper levels NP_015034.1 1074211 D 4932 CDS NP_015035.1 6324966 854572 1076782..1077909 1 NC_001147.5 Yor390wp; Putative protein of unknown function 1077909 854572 YOR390W Saccharomyces cerevisiae Putative protein of unknown function NP_015035.1 1076782 D 4932 CDS NP_015036.1 6324967 854573 complement(1078543..1079256) 1 NC_001147.5 Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; Hsp33p 1079256 HSP33 854573 HSP33 Saccharomyces cerevisiae Hsp33p NP_015036.1 1078543 R 4932 CDS NP_015038.1 6324969 854575 1080274..1081587 1 NC_001147.5 Protein of unknown function, has similarity to enolases; Err1p 1081587 ERR1 854575 ERR1 Saccharomyces cerevisiae Err1p NP_015038.1 1080274 D 4932 CDS NP_015039.1 6324970 854576 1082716..1083210 1 NC_001147.5 Pau21p 1083210 PAU21 854576 PAU21 Saccharomyces cerevisiae Pau21p NP_015039.1 1082716 D 4932 CDS NP_878178.1 33438890 1466490 complement(1084200..1084367) 1 NC_001147.5 Yor394c-ap; Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 1084367 1466490 YOR394C-A Saccharomyces cerevisiae Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching NP_878178.1 1084200 R 4932 CDS NP_061495.2 126182981 854577 1085471..1090861 1 NC_001147.5 Yrf1-8p; One of several telomeric Y' element-encoded DNA helicases, known as Y'-Help1 (Y'-HELicase Protein 1) 1090861 YRF1-8 854577 YRF1-8 Saccharomyces cerevisiae One of several telomeric Y' element-encoded DNA helicases, known as Y'-Help1 (Y'-HELicase Protein 1) NP_061495.2 1085471 D 4932 CDS NP_015040.1 6324972 855846 complement(join(280..5840,5989..6007)) 1 NC_001148.3 Yrf1-7p; Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p 6007 YRF1-7 855846 YRF1-7 Saccharomyces cerevisiae Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p NP_015040.1 280 R 4932 CDS NP_015041.1 6324973 855847 complement(7933..8427) 1 NC_001148.3 Pau22p 8427 PAU22 855847 PAU22 Saccharomyces cerevisiae Pau22p NP_015041.1 7933 R 4932 CDS NP_015042.1 6324974 855848 complement(9557..10870) 1 NC_001148.3 Protein of unknown function, has similarity to enolases; Err2p 10870 ERR2 855848 ERR2 Saccharomyces cerevisiae Err2p NP_015042.1 9557 R 4932 CDS NP_015043.1 6324975 855849 11887..12600 1 NC_001148.3 Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp33p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; Hsp32p 12600 HSP32 855849 HSP32 Saccharomyces cerevisiae Hsp32p NP_015043.1 11887 D 4932 CDS NP_015044.1 6324976 855850 complement(13228..14355) 1 NC_001148.3 Ypl279cp; Putative protein of unknown function 14355 855850 YPL279C Saccharomyces cerevisiae Putative protein of unknown function NP_015044.1 13228 R 4932 CDS NP_015045.1 6324977 855851 complement(15053..15355) 1 NC_001148.3 Ypl278cp; Putative protein of unknown function; gene expression regulated by copper levels 15355 855851 YPL278C Saccharomyces cerevisiae Putative protein of unknown function; gene expression regulated by copper levels NP_015045.1 15053 R 4932 CDS NP_015046.1 6324978 855852 complement(15405..16868) 1 NC_001148.3 Ypl277cp; Putative protein of unknown function; localized to the membranes; gene expression regulated by copper levels 16868 855852 YPL277C Saccharomyces cerevisiae Putative protein of unknown function; localized to the membranes; gene expression regulated by copper levels NP_015046.1 15405 R 4932 CDS NP_015049.1 6324981 855854 22938..24701 1 NC_001148.3 Sam3p; High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p 24701 SAM3 855854 SAM3 Saccharomyces cerevisiae High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p NP_015049.1 22938 D 4932 CDS NP_015050.1 6324982 855855 25087..26064 1 NC_001148.3 Sam4p; S-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio 26064 SAM4 855855 SAM4 Saccharomyces cerevisiae S-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio NP_015050.1 25087 D 4932 CDS NP_015051.1 6324983 855856 complement(26611..28164) 1 NC_001148.3 Ypl272cp; Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene 28164 855856 YPL272C Saccharomyces cerevisiae Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene NP_015051.1 26611 R 4932 CDS NP_015052.1 6324984 855857 30079..30267 1 NC_001148.3 Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated; Atp15p 30267 ATP15 855857 ATP15 Saccharomyces cerevisiae Atp15p NP_015052.1 30079 D 4932 CDS NP_015053.2 37362699 855858 30482..32803 1 NC_001148.3 Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter; Mdl2p 32803 MDL2 855858 MDL2 Saccharomyces cerevisiae Mdl2p NP_015053.2 30482 D 4932 CDS NP_015054.1 6324986 855859 33013..34947 1 NC_001148.3 Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase; Kar9p 34947 KAR9 855859 KAR9 Saccharomyces cerevisiae Kar9p NP_015054.1 33013 D 4932 CDS NP_015055.1 6324987 855860 35236..37845 1 NC_001148.3 Plc1p; Phosphoinositide-specific phospholipase C, hydrolyzes phosphatidylinositol 4,5-biphosphate (PIP2) to generate inositol 1,4,5-triphosphate (IP3) and 1,2-diacylglycerol (DAG); involved in kinetochore function and pseudohyphal differentiation 37845 PLC1 855860 PLC1 Saccharomyces cerevisiae Phosphoinositide-specific phospholipase C, hydrolyzes phosphatidylinositol 4,5-biphosphate (PIP2) to generate inositol 1,4,5-triphosphate (IP3) and 1,2-diacylglycerol (DAG); involved in kinetochore function and pseudohyphal differentiation NP_015055.1 35236 D 4932 CDS NP_015056.1 6324988 855861 38169..38798 1 NC_001148.3 Cell cycle regulated protein of unknown function; associated with Cdh1p and may supress the APC/C[Cdh1]-mediated proteolysis of mitotic cyclins; Acm1p 38798 ACM1 855861 ACM1 Saccharomyces cerevisiae Acm1p NP_015056.1 38169 D 4932 CDS NP_015057.1 6324989 855862 39121..40077 1 NC_001148.3 Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing; Dim1p 40077 DIM1 855862 DIM1 Saccharomyces cerevisiae Dim1p NP_015057.1 39121 D 4932 CDS NP_015058.1 6324990 855863 41043..42869 1 NC_001148.3 Dip5p; Dicarboxylic amino acid permease, mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly 42869 DIP5 855863 DIP5 Saccharomyces cerevisiae Dicarboxylic amino acid permease, mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly NP_015058.1 41043 D 4932 CDS NP_015059.1 6324991 855864 complement(43283..44344) 1 NC_001148.3 Ypl264cp; Putative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene 44344 855864 YPL264C Saccharomyces cerevisiae Putative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene NP_015059.1 43283 R 4932 CDS NP_015060.1 6324992 855865 complement(44551..46506) 1 NC_001148.3 Kel3p; Cytoplasmic protein of unknown function 46506 KEL3 855865 KEL3 Saccharomyces cerevisiae Cytoplasmic protein of unknown function NP_015060.1 44551 R 4932 CDS NP_015061.1 6324993 855866 47336..48802 1 NC_001148.3 Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation; phosphorylated in mitochondria; Fum1p 48802 FUM1 855866 FUM1 Saccharomyces cerevisiae Fum1p NP_015061.1 47336 D 4932 CDS NP_015063.1 6324994 855867 49303..50958 1 NC_001148.3 Ypl260wp; Putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene 50958 855867 YPL260W Saccharomyces cerevisiae Putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene NP_015063.1 49303 D 4932 CDS NP_015064.1 6324996 855869 complement(51244..52671) 1 NC_001148.3 Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting; Apm1p 52671 APM1 855869 APM1 Saccharomyces cerevisiae Apm1p NP_015064.1 51244 R 4932 CDS NP_015065.1 6324997 855870 complement(53498..55153) 1 NC_001148.3 Thi21p; Hydroxymethylpyrimidine phosphate kinase, involved in the last steps in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p 55153 THI21 855870 THI21 Saccharomyces cerevisiae Hydroxymethylpyrimidine phosphate kinase, involved in the last steps in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p NP_015065.1 53498 R 4932 CDS NP_058189.1 7839205 855817 join(56748..58052,58054..62016) 1 NC_001148.3 Ypl257w-bp; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 62016 855817 YPL257W-B Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_058189.1 56748 D 4932 CDS NP_058190.1 7839204 855816 56748..58070 1 NC_001148.3 Ypl257w-ap; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 58070 855816 YPL257W-A Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_058190.1 56748 D 4932 CDS NP_015066.1 6324998 855818 63279..63860 1 NC_001148.3 Ypl257wp; Putative protein of unknown function;; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene 63860 855818 YPL257W Saccharomyces cerevisiae Putative protein of unknown function;; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene NP_015066.1 63279 D 4932 CDS NP_015067.1 6324999 855819 complement(64977..66614) 1 NC_001148.3 G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p); Cln2p 66614 CLN2 855819 CLN2 Saccharomyces cerevisiae Cln2p NP_015067.1 64977 R 4932 CDS NP_015068.1 6325000 855820 67725..68882 1 NC_001148.3 Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p; Bbp1p 68882 BBP1 855820 BBP1 Saccharomyces cerevisiae Bbp1p NP_015068.1 67725 D 4932 CDS NP_015069.1 6325001 855821 69485..70951 1 NC_001148.3 Hfi1p; Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions 70951 HFI1 855821 HFI1 Saccharomyces cerevisiae Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions NP_015069.1 69485 D 4932 CDS NP_015070.1 6325002 855822 complement(71063..73006) 1 NC_001148.3 Vik1p; Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion; has similarity to Cik1p 73006 VIK1 855822 VIK1 Saccharomyces cerevisiae Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion; has similarity to Cik1p NP_015070.1 71063 R 4932 CDS NP_015071.1 6325004 855824 complement(73363..73881) 1 NC_001148.3 Yah1p; Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin 73881 YAH1 855824 YAH1 Saccharomyces cerevisiae Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin NP_015071.1 73363 R 4932 CDS NP_015073.1 6325005 855825 complement(74309..74719) 1 NC_001148.3 Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate; Icy2p 74719 ICY2 855825 ICY2 Saccharomyces cerevisiae Icy2p NP_015073.1 74309 R 4932 CDS NP_015074.1 6325006 855826 complement(join(75699..75985,76224..76239)) 1 NC_001148.3 Rpl36bp; Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Ap and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA 76239 RPL36B 855826 RPL36B Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Ap and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA NP_015074.1 75699 R 4932 CDS NP_015075.1 6325007 855827 complement(76669..79353) 1 NC_001148.3 Gyp5p; GTPase-activating protein (GAP) for yeast Rab family members, involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p 79353 GYP5 855827 GYP5 Saccharomyces cerevisiae GTPase-activating protein (GAP) for yeast Rab family members, involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p NP_015075.1 76669 R 4932 CDS NP_015076.1 6325008 855828 complement(79711..82356) 1 NC_001148.3 Gal4p; DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p 82356 GAL4 855828 GAL4 Saccharomyces cerevisiae DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p NP_015076.1 79711 R 4932 CDS NP_015077.1 6325009 855829 complement(82625..84196) 1 NC_001148.3 Ypl247cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; YPL247C is not an essential gene 84196 855829 YPL247C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; YPL247C is not an essential gene NP_015077.1 82625 R 4932 CDS NP_015078.1 6325010 855830 complement(84509..85297) 1 NC_001148.3 Rbd2p; Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p 85297 RBD2 855830 RBD2 Saccharomyces cerevisiae Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p NP_015078.1 84509 R 4932 CDS NP_015079.1 6325011 855831 85586..86950 1 NC_001148.3 Ypl245wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm 86950 855831 YPL245W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm NP_015079.1 85586 D 4932 CDS NP_015080.1 6325012 855832 complement(87014..88033) 1 NC_001148.3 Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1; Hut1p 88033 HUT1 855832 HUT1 Saccharomyces cerevisiae Hut1p NP_015080.1 87014 R 4932 CDS NP_015081.1 6325013 855833 88517..90316 1 NC_001148.3 Srp68p; Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane 90316 SRP68 855833 SRP68 Saccharomyces cerevisiae Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane NP_015081.1 88517 D 4932 CDS NP_015082.1 6325014 855834 complement(90622..95109) 1 NC_001148.3 Iqg1p; Essential protein required for determination of budding pattern, promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family 95109 IQG1 855834 IQG1 Saccharomyces cerevisiae Essential protein required for determination of budding pattern, promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family NP_015082.1 90622 R 4932 CDS NP_015083.1 6325015 855835 complement(join(95372..96153,96234..96258)) 1 NC_001148.3 Tubulin folding factor C (putative) involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; Cin2p 96258 CIN2 855835 CIN2 Saccharomyces cerevisiae Cin2p NP_015083.1 95372 R 4932 CDS NP_015084.1 6325016 855836 complement(96496..98625) 1 NC_001148.3 Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p; Hsp82p 98625 HSP82 855836 HSP82 Saccharomyces cerevisiae Hsp82p NP_015084.1 96496 R 4932 CDS NP_015085.1 6325017 855837 99484..100086 1 NC_001148.3 Yar1p; Cytoplasmic ankyrin-repeat containing protein of unknown function, proposed to link the processes of 40S ribosomal subunit biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock 100086 YAR1 855837 YAR1 Saccharomyces cerevisiae Cytoplasmic ankyrin-repeat containing protein of unknown function, proposed to link the processes of 40S ribosomal subunit biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock NP_015085.1 99484 D 4932 CDS NP_015087.1 6325018 855838 100496..101353 1 NC_001148.3 Sui3p; Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding 101353 SUI3 855838 SUI3 Saccharomyces cerevisiae Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding NP_015087.1 100496 D 4932 CDS NP_015088.1 6325020 855840 complement(101608..102702) 1 NC_001148.3 Ypl236cp; Putative protein kinase that exhibits Akr1p-dependent palmitoylation 102702 855840 YPL236C Saccharomyces cerevisiae Putative protein kinase that exhibits Akr1p-dependent palmitoylation NP_015088.1 101608 R 4932 CDS NP_015089.1 6325021 855841 103232..104647 1 NC_001148.3 Rvb2p; Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; member of the RUVB-like protein family 104647 RVB2 855841 RVB2 Saccharomyces cerevisiae Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; member of the RUVB-like protein family NP_015089.1 103232 D 4932 CDS NP_015090.1 6325022 855842 complement(104946..105440) 1 NC_001148.3 Vacuolar ATPase V0 domain subunit c', involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen; Tfp3p 105440 TFP3 855842 TFP3 Saccharomyces cerevisiae Tfp3p NP_015090.1 104946 R 4932 CDS NP_015091.1 6325023 855843 106172..106822 1 NC_001148.3 Nsl1p; Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation 106822 NSL1 855843 NSL1 Saccharomyces cerevisiae Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation NP_015091.1 106172 D 4932 CDS NP_015092.1 6325024 855844 107275..108147 1 NC_001148.3 Sso1p; Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p 108147 SSO1 855844 SSO1 Saccharomyces cerevisiae Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p NP_015092.1 107275 D 4932 CDS NP_015093.1 6325025 855845 108652..114315 1 NC_001148.3 Fas2p; Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains beta-ketoacyl reductase and beta-ketoacyl synthase activities; phosphorylated 114315 FAS2 855845 FAS2 Saccharomyces cerevisiae Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains beta-ketoacyl reductase and beta-ketoacyl synthase activities; phosphorylated NP_015093.1 108652 D 4932 CDS NP_015094.1 6325026 855871 115312..116487 1 NC_001148.3 Usv1p; Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in protein folding, ATP binding, and cell wall biosynthesis 116487 USV1 855871 USV1 Saccharomyces cerevisiae Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in protein folding, ATP binding, and cell wall biosynthesis NP_015094.1 115312 D 4932 CDS NP_015095.1 6325027 855872 117067..117687 1 NC_001148.3 Ypl229wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL229W is not an essential gene 117687 855872 YPL229W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL229W is not an essential gene NP_015095.1 117067 D 4932 CDS NP_015096.1 6325028 855873 118382..120031 1 NC_001148.3 Cet1p; Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide 120031 CET1 855873 CET1 Saccharomyces cerevisiae Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide NP_015096.1 118382 D 4932 CDS NP_015097.1 6325029 855874 complement(120163..121167) 1 NC_001148.3 UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum; Alg5p 121167 ALG5 855874 ALG5 Saccharomyces cerevisiae Alg5p NP_015097.1 120163 R 4932 CDS NP_015098.1 6325030 855875 121767..125357 1 NC_001148.3 New1p; ATP binding cassette family member; Asn/Gln-rich rich region supports [NU+] prion formation, susceptibility to [PSI+] prion induction and aggregation of a fragment of the human Machado-Joseph Disease protein 125357 NEW1 855875 NEW1 Saccharomyces cerevisiae ATP binding cassette family member; Asn/Gln-rich rich region supports [NU+] prion formation, susceptibility to [PSI+] prion induction and aggregation of a fragment of the human Machado-Joseph Disease protein NP_015098.1 121767 D 4932 CDS NP_015099.1 6325031 855876 126006..126446 1 NC_001148.3 Ypl225wp; Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 126446 855876 YPL225W Saccharomyces cerevisiae Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm NP_015099.1 126006 D 4932 CDS NP_015100.1 6325032 855877 complement(126738..128087) 1 NC_001148.3 Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p; Mmt2p 128087 MMT2 855877 MMT2 Saccharomyces cerevisiae Mmt2p NP_015100.1 126738 R 4932 CDS NP_015101.1 6325033 855878 complement(128631..129137) 1 NC_001148.3 Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; Gre1p 129137 GRE1 855878 GRE1 Saccharomyces cerevisiae Gre1p NP_015101.1 128631 R 4932 CDS NP_015102.1 6325034 855879 130161..132227 1 NC_001148.3 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Fmp40p 132227 FMP40 855879 FMP40 Saccharomyces cerevisiae Fmp40p NP_015102.1 130161 D 4932 CDS NP_015103.1 6325035 855880 133042..135423 1 NC_001148.3 Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; Flc1p 135423 FLC1 855880 FLC1 Saccharomyces cerevisiae Flc1p NP_015103.1 133042 D 4932 CDS NP_015104.1 6325036 855881 135789..136442 1 NC_001148.3 Rpl1ap; N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Bp and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal 136442 RPL1A 855881 RPL1A Saccharomyces cerevisiae N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Bp and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal NP_015104.1 135789 D 4932 CDS NP_015105.1 6325037 855882 136749..138227 1 NC_001148.3 Pcl8p; Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation 138227 PCL8 855882 PCL8 Saccharomyces cerevisiae Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation NP_015105.1 136749 D 4932 CDS NP_015106.1 6325038 855883 join(138697..138724,138864..139408) 1 NC_001148.3 Sar1p; GTPase, GTP-binding protein of the ARF family, component of COPII coat of vesicles; required for transport vesicle formation during ER to Golgi protein transport 139408 SAR1 855883 SAR1 Saccharomyces cerevisiae GTPase, GTP-binding protein of the ARF family, component of COPII coat of vesicles; required for transport vesicle formation during ER to Golgi protein transport NP_015106.1 138697 D 4932 CDS NP_015107.1 6325039 855884 complement(139619..143170) 1 NC_001148.3 Essential conserved nucleolar GTP-binding protein required for synthesis of 40S ribosomal subunits and for processing of the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, has similarity to Tsr1p; Bms1p 143170 BMS1 855884 BMS1 Saccharomyces cerevisiae Bms1p NP_015107.1 139619 R 4932 CDS NP_015108.1 6325040 855885 143820..147128 1 NC_001148.3 Ypl216wp; Putative protein of unknown function; YPL216W is not an essential gene 147128 855885 YPL216W Saccharomyces cerevisiae Putative protein of unknown function; YPL216W is not an essential gene NP_015108.1 143820 D 4932 CDS NP_015109.1 6325041 855886 147415..148422 1 NC_001148.3 Mitochondrial protein required for assembly of ubiquinol cytochrome-c reductase complex (cytochrome bc1 complex); interacts with Cbp4p and function is partially redundant with that of Cbp4p; Cbp3p 148422 CBP3 855886 CBP3 Saccharomyces cerevisiae Cbp3p NP_015109.1 147415 D 4932 CDS NP_015110.1 6325042 855887 complement(148568..150190) 1 NC_001148.3 Thi6p; Bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities, required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern 150190 THI6 855887 THI6 Saccharomyces cerevisiae Bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities, required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern NP_015110.1 148568 R 4932 CDS NP_015111.1 6325043 855888 150613..151329 1 NC_001148.3 Lea1p; Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; invovled in telomere maintenance; putative homolog of human U2A' snRNP protein 151329 LEA1 855888 LEA1 Saccharomyces cerevisiae Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; invovled in telomere maintenance; putative homolog of human U2A' snRNP protein NP_015111.1 150613 D 4932 CDS NP_015112.1 6325044 855889 complement(151514..153148) 1 NC_001148.3 tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA; Pus1p 153148 PUS1 855889 PUS1 Saccharomyces cerevisiae Pus1p NP_015112.1 151514 R 4932 CDS NP_015113.1 6325045 855890 153494..154039 1 NC_001148.3 Nucleolar protein required for 60S ribosome subunit biogenesis, constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p; Nip7p 154039 NIP7 855890 NIP7 Saccharomyces cerevisiae Nip7p NP_015113.1 153494 D 4932 CDS NP_015114.2 37362700 855891 complement(154289..156211) 1 NC_001148.3 Srp72p; Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane 156211 SRP72 855891 SRP72 Saccharomyces cerevisiae Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane NP_015114.2 154289 R 4932 CDS NP_015115.1 6325047 855892 complement(156489..157592) 1 NC_001148.3 Ipl1p; Aurora kinase involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase; associates with Sli15p, which promotes Ipl1p association with mitotic spindle 157592 IPL1 855892 IPL1 Saccharomyces cerevisiae Aurora kinase involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase; associates with Sli15p, which promotes Ipl1p association with mitotic spindle NP_015115.1 156489 R 4932 CDS NP_015116.1 6325048 855893 157841..159592 1 NC_001148.3 SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the large ribsomal subunit protein L23a (RPL23A and RPL23B); Rkm1p 159592 RKM1 855893 RKM1 Saccharomyces cerevisiae Rkm1p NP_015116.1 157841 D 4932 CDS NP_015117.1 6325049 855894 159908..162340 1 NC_001148.3 Tyw1p; Protein required for the synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions 162340 TYW1 855894 TYW1 Saccharomyces cerevisiae Protein required for the synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions NP_015117.1 159908 D 4932 CDS NP_015118.1 6325050 855895 complement(162631..163596) 1 NC_001148.3 Ypl206cp; Protein that plays a role in metabolism of glycerophosphocholine to phosphatidylcholine; contains glycerophosphodiester phosphodiesterase motifs 163596 855895 YPL206C Saccharomyces cerevisiae Protein that plays a role in metabolism of glycerophosphocholine to phosphatidylcholine; contains glycerophosphodiester phosphodiesterase motifs NP_015118.1 162631 R 4932 CDS NP_015120.1 6325052 855897 164275..165759 1 NC_001148.3 Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta); Hrr25p 165759 HRR25 855897 HRR25 Saccharomyces cerevisiae Hrr25p NP_015120.1 164275 D 4932 CDS NP_015121.1 6325053 855898 166255..167397 1 NC_001148.3 cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk1p and Tpk3p; Tpk2p 167397 TPK2 855898 TPK2 Saccharomyces cerevisiae Tpk2p NP_015121.1 166255 D 4932 CDS NP_015122.1 6325054 855899 complement(168087..169337) 1 NC_001148.3 Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; similar to Aft1p; Aft2p 169337 AFT2 855899 AFT2 Saccharomyces cerevisiae Aft2p NP_015122.1 168087 R 4932 CDS NP_015123.1 6325055 855900 complement(169769..171154) 1 NC_001148.3 Yig1p; Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol 171154 YIG1 855900 YIG1 Saccharomyces cerevisiae Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol NP_015123.1 169769 R 4932 CDS NP_015124.1 6325056 855901 171483..171953 1 NC_001148.3 Protein required for accurate chromosome segregation during meiosis; Csm4p 171953 CSM4 855901 CSM4 Saccharomyces cerevisiae Csm4p NP_015124.1 171483 D 4932 CDS NP_015125.1 6325057 855902 complement(172032..172754) 1 NC_001148.3 Ypl199cp 172754 855902 YPL199C Saccharomyces cerevisiae Ypl199cp NP_015125.1 172032 R 4932 CDS NP_015126.1 6325058 855903 join(173151..173161,173571..173664,174072..174701) 1 NC_001148.3 Rpl7bp; Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Ap and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2) 174701 RPL7B 855903 RPL7B Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Ap and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2) NP_015126.1 173151 D 4932 CDS NP_015128.1 6325060 855905 175042..175863 1 NC_001148.3 Protein of unknown function required for normal levels of resistance to oxidative damage, null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes but not in prokaryotes; Oxr1p 175863 OXR1 855905 OXR1 Saccharomyces cerevisiae Oxr1p NP_015128.1 175042 D 4932 CDS NP_015129.1 6325061 855906 176222..179020 1 NC_001148.3 Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function; Apl5p 179020 APL5 855906 APL5 Saccharomyces cerevisiae Apl5p NP_015129.1 176222 D 4932 CDS NP_015130.1 6325062 855907 179276..181114 1 NC_001148.3 Ddc1p; DNA damage checkpoint protein, part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate 181114 DDC1 855907 DDC1 Saccharomyces cerevisiae DNA damage checkpoint protein, part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate NP_015130.1 179276 D 4932 CDS NP_015131.1 6325063 855908 181402..182547 1 NC_001148.3 Rsa1p; Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly 182547 RSA1 855908 RSA1 Saccharomyces cerevisiae Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly NP_015131.1 181402 D 4932 CDS NP_015132.1 6325064 855909 complement(182654..183055) 1 NC_001148.3 Prm3p; Pheromone-regulated protein required for karyogamy; localizes to the inner membrane of the nuclear envelope 183055 PRM3 855909 PRM3 Saccharomyces cerevisiae Pheromone-regulated protein required for karyogamy; localizes to the inner membrane of the nuclear envelope NP_015132.1 182654 R 4932 CDS NP_015133.1 6325065 855910 complement(183596..184678) 1 NC_001148.3 Ypl191cp; Putative protein of unknown function; diploid deletion strain exhibits high budding index; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 184678 855910 YPL191C Saccharomyces cerevisiae Putative protein of unknown function; diploid deletion strain exhibits high budding index; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm NP_015133.1 183596 R 4932 CDS NP_015134.1 6325066 855911 complement(185316..187724) 1 NC_001148.3 Single stranded RNA binding protein; acidic ribonucleoprotein; required for termination of non-poly(A) transcripts and efficient splicing; interacts with Nrd1p; Nab3p 187724 NAB3 855911 NAB3 Saccharomyces cerevisiae Nab3p NP_015134.1 185316 R 4932 CDS NP_878179.1 33438891 1466518 complement(188306..188512) 1 NC_001148.3 Putative cytochrome oxidase assembly factor; identified by homology to Ashbya gossypii; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; Coa2p 188512 COA2 1466518 COA2 Saccharomyces cerevisiae Coa2p NP_878179.1 188306 R 4932 CDS NP_015135.1 6325067 855912 189153..190982 1 NC_001148.3 Probable membrane protein with a possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases; Gup1p homolog; Gup2p 190982 GUP2 855912 GUP2 Saccharomyces cerevisiae Gup2p NP_015135.1 189153 D 4932 CDS NP_015136.1 6325068 855913 191405..192649 1 NC_001148.3 Pos5p; Mitochondrial NADH kinase, phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress 192649 POS5 855913 POS5 Saccharomyces cerevisiae Mitochondrial NADH kinase, phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress NP_015136.1 191405 D 4932 CDS NP_015137.1 6325069 855914 193647..194144 1 NC_001148.3 Mf(alpha)1p; Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor 194144 MF(ALPHA)1 855914 MF(ALPHA)1 Saccharomyces cerevisiae Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor NP_015137.1 193647 D 4932 CDS NP_015138.1 6325071 855916 complement(194511..195425) 1 NC_001148.3 Uip4p; Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope 195425 UIP4 855916 UIP4 Saccharomyces cerevisiae Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope NP_015138.1 194511 R 4932 CDS NP_015140.1 6325072 855917 complement(195949..197787) 1 NC_001148.3 Putative RNA binding protein; Mrn1p 197787 MRN1 855917 MRN1 Saccharomyces cerevisiae Mrn1p NP_015140.1 195949 R 4932 CDS NP_015141.1 6325073 855918 199094..199375 1 NC_001148.3 Ypl183w-ap; Homolog of the prokaryotic ribosomal protein L36, likely to be a mitochondrial ribosomal protein coded in the nuclear genome 199375 855918 YPL183W-A Saccharomyces cerevisiae Homolog of the prokaryotic ribosomal protein L36, likely to be a mitochondrial ribosomal protein coded in the nuclear genome NP_015141.1 199094 D 4932 CDS NP_015142.1 6325074 855919 complement(199494..202535) 1 NC_001148.3 Rtt10p; Cytoplasmic protein of unknown function, plays a role in restricting Ty1 transposition 202535 RTT10 855919 RTT10 Saccharomyces cerevisiae Cytoplasmic protein of unknown function, plays a role in restricting Ty1 transposition NP_015142.1 199494 R 4932 CDS NP_015144.1 6325075 855920 203420..204940 1 NC_001148.3 Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain; Cti6p 204940 CTI6 855920 CTI6 Saccharomyces cerevisiae Cti6p NP_015144.1 203420 D 4932 CDS NP_015145.1 6325077 855922 205247..207646 1 NC_001148.3 Tco89p; Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complex that regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin 207646 TCO89 855922 TCO89 Saccharomyces cerevisiae Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complex that regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin NP_015145.1 205247 D 4932 CDS NP_015146.1 6325078 855923 208156..209805 1 NC_001148.3 Putative protein serine/threonine phosphatase; null mutation enhances efficiency of translational suppressors; Ppq1p 209805 PPQ1 855923 PPQ1 Saccharomyces cerevisiae Ppq1p NP_015146.1 208156 D 4932 CDS NP_015147.1 6325079 855925 212157..212783 1 NC_001148.3 Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif; Cbc2p 212783 CBC2 855925 CBC2 Saccharomyces cerevisiae Cbc2p NP_015147.1 212157 D 4932 CDS NP_015148.1 6325080 855926 complement(213041..213961) 1 NC_001148.3 Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; Cup9p 213961 CUP9 855926 CUP9 Saccharomyces cerevisiae Cup9p NP_015148.1 213041 R 4932 CDS NP_015149.1 6325081 855927 complement(216011..218362) 1 NC_001148.3 Tre1p; Plasma membrane protein that binds to Bsd2p and regulates ubiquitylation and vacuolar degradation of the metal transporter Smf1p; function is redundant with that of Tre2p; has similarity to transferrin receptors 218362 TRE1 855927 TRE1 Saccharomyces cerevisiae Plasma membrane protein that binds to Bsd2p and regulates ubiquitylation and vacuolar degradation of the metal transporter Smf1p; function is redundant with that of Tre2p; has similarity to transferrin receptors NP_015149.1 216011 R 4932 CDS NP_015150.2 9755344 855928 join(218629..218645,218746..220087) 1 NC_001148.3 UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins; Spt14p 220087 SPT14 855928 SPT14 Saccharomyces cerevisiae Spt14p NP_015150.2 218629 D 4932 CDS NP_015151.1 6325083 855929 complement(220166..222772) 1 NC_001148.3 Nip100p; Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued) 222772 NIP100 855929 NIP100 Saccharomyces cerevisiae Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued) NP_015151.1 220166 R 4932 CDS NP_015152.1 6325084 855930 223142..224035 1 NC_001148.3 Mrpl40p; Mitochondrial ribosomal protein of the large subunit 224035 MRPL40 855930 MRPL40 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit NP_015152.1 223142 D 4932 CDS NP_015153.1 6325085 855931 complement(224352..225740) 1 NC_001148.3 Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders; Cox10p 225740 COX10 855931 COX10 Saccharomyces cerevisiae Cox10p NP_015153.1 224352 R 4932 CDS NP_015154.1 6325086 855932 complement(226168..227370) 1 NC_001148.3 Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism; Oye3p 227370 OYE3 855932 OYE3 Saccharomyces cerevisiae Oye3p NP_015154.1 226168 R 4932 CDS NP_015155.1 6325087 855933 228313..228771 1 NC_001148.3 Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis; Dap1p 228771 DAP1 855933 DAP1 Saccharomyces cerevisiae Dap1p NP_015155.1 228313 D 4932 CDS NP_015156.1 6325088 855934 complement(229038..230837) 1 NC_001148.3 Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP; Mex67p 230837 MEX67 855934 MEX67 Saccharomyces cerevisiae Mex67p NP_015156.1 229038 R 4932 CDS NP_015157.1 6325089 855935 231216..232508 1 NC_001148.3 Ypl168wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated 232508 855935 YPL168W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated NP_015157.1 231216 D 4932 CDS NP_015158.1 6325090 855936 complement(232592..237106) 1 NC_001148.3 Rev3p; Catalytic subunit of DNA polymerase zeta, which is involved in DNA repair and translesion synthesis; required for mutagenesis induced by DNA damage 237106 REV3 855936 REV3 Saccharomyces cerevisiae Catalytic subunit of DNA polymerase zeta, which is involved in DNA repair and translesion synthesis; required for mutagenesis induced by DNA damage NP_015158.1 232592 R 4932 CDS NP_015159.1 6325091 855937 237337..237978 1 NC_001148.3 Protein specifically required for autophagy; may function in autophagosome formation at the pre-autophagosomal structure in collaboration with other autophagy proteins; Atg29p 237978 ATG29 855937 ATG29 Saccharomyces cerevisiae Atg29p NP_015159.1 237337 D 4932 CDS NP_015160.1 6325092 855938 complement(237955..239076) 1 NC_001148.3 Set6p; Protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability 239076 SET6 855938 SET6 Saccharomyces cerevisiae Protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability NP_015160.1 237955 R 4932 CDS NP_015161.1 6325093 855939 complement(239349..241496) 1 NC_001148.3 Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability; Mlh3p 241496 MLH3 855939 MLH3 Saccharomyces cerevisiae Mlh3p NP_015161.1 239349 R 4932 CDS NP_015162.1 6325094 855940 complement(241917..242699) 1 NC_001148.3 Svs1p; Cell wall and vacuolar protein, required for wild-type resistance to vanadate 242699 SVS1 855940 SVS1 Saccharomyces cerevisiae Cell wall and vacuolar protein, required for wild-type resistance to vanadate NP_015162.1 241917 R 4932 CDS NP_015163.1 6325095 855941 complement(243205..244026) 1 NC_001148.3 Ypl162cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of vacuole with cell cycle-correlated morphology 244026 855941 YPL162C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of vacuole with cell cycle-correlated morphology NP_015163.1 243205 R 4932 CDS NP_015164.1 6325096 855942 complement(244318..246219) 1 NC_001148.3 Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length; Bem4p 246219 BEM4 855942 BEM4 Saccharomyces cerevisiae Bem4p NP_015164.1 244318 R 4932 CDS NP_015165.1 6325097 855943 246989..250261 1 NC_001148.3 Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA; Cdc60p 250261 CDC60 855943 CDC60 Saccharomyces cerevisiae Cdc60p NP_015165.1 246989 D 4932 CDS NP_015166.1 6325098 855944 complement(250906..251667) 1 NC_001148.3 Pet20p; Mitochondrial protein, required for respiratory growth under some conditions and for stability of the mitochondrial genome 251667 PET20 855944 PET20 Saccharomyces cerevisiae Mitochondrial protein, required for respiratory growth under some conditions and for stability of the mitochondrial genome NP_015166.1 250906 R 4932 CDS NP_015167.1 6325099 855945 complement(252033..254309) 1 NC_001148.3 Protein of unknown function; null mutant displays increased frequency of mitochondrial genome loss (petite formation) and reduced growth rate in minimal glycerol media; Aim44p 254309 AIM44 855945 AIM44 Saccharomyces cerevisiae Aim44p NP_015167.1 252033 R 4932 CDS NP_015168.1 6325100 855946 254813..255760 1 NC_001148.3 Trimethyl guanosine synthase, conserved nucleolar methyl transferase responsible for conversion of the m(7)G cap structure of snRNAs and snoRNAs to m(2,2,7)G; also required for ribosome synthesis and nucleolar morphology; Tgs1p 255760 TGS1 855946 TGS1 Saccharomyces cerevisiae Tgs1p NP_015168.1 254813 D 4932 CDS NP_015169.1 6325101 855947 complement(255912..256766) 1 NC_001148.3 Prm4p; Pheromone-regulated protein, predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift 256766 PRM4 855947 PRM4 Saccharomyces cerevisiae Pheromone-regulated protein, predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift NP_015169.1 255912 R 4932 CDS NP_015170.1 6325102 855948 complement(257215..259335) 1 NC_001148.3 Kip2p; Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle 259335 KIP2 855948 KIP2 Saccharomyces cerevisiae Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle NP_015170.1 257215 R 4932 CDS NP_015171.1 6325103 855949 complement(259713..260930) 1 NC_001148.3 Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; synthesized as a zymogen, self-activates; Pep4p 260930 PEP4 855949 PEP4 Saccharomyces cerevisiae Pep4p NP_015171.1 259713 R 4932 CDS NP_015172.1 6325104 855950 complement(261726..264191) 1 NC_001148.3 Rad53p; Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication 264191 RAD53 855950 RAD53 Saccharomyces cerevisiae Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication NP_015172.1 261726 R 4932 CDS NP_878180.1 33438892 1466519 264601..264699 1 NC_001148.3 Ypl152w-ap; Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 264699 1466519 YPL152W-A Saccharomyces cerevisiae Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching NP_878180.1 264601 D 4932 CDS NP_015173.1 6325105 855951 265027..266103 1 NC_001148.3 Rrd2p; Activator of the phosphotyrosyl phosphatase activity of PP2A,peptidyl-prolyl cis/trans-isomerase; regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex 266103 RRD2 855951 RRD2 Saccharomyces cerevisiae Activator of the phosphotyrosyl phosphatase activity of PP2A,peptidyl-prolyl cis/trans-isomerase; regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex NP_015173.1 265027 D 4932 CDS NP_015174.1 6325106 855952 complement(266179..267534) 1 NC_001148.3 Splicing factor that is found in the Cef1p subcomplex of the spliceosome; Prp46p 267534 PRP46 855952 PRP46 Saccharomyces cerevisiae Prp46p NP_015174.1 266179 R 4932 CDS NP_015175.1 6325107 855953 268187..270892 1 NC_001148.3 Ypl150wp; Putative protein kinase of unknown cellular role 270892 855953 YPL150W Saccharomyces cerevisiae Putative protein kinase of unknown cellular role NP_015175.1 268187 D 4932 CDS NP_015176.1 6325108 855954 271309..272193 1 NC_001148.3 Conserved autophagy-related protein that undergoes conjugation with Atg12p and then associates with Atg16p to form a cytosolic complex essential for autophagosome formation; Atg5p 272193 ATG5 855954 ATG5 Saccharomyces cerevisiae Atg5p NP_015176.1 271309 D 4932 CDS NP_015177.2 37362701 855955 complement(272293..272814) 1 NC_001148.3 Ppt2p; Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation 272814 PPT2 855955 PPT2 Saccharomyces cerevisiae Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation NP_015177.2 272293 R 4932 CDS NP_015178.1 6325110 855956 273254..275866 1 NC_001148.3 Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins; Pxa1p 275866 PXA1 855956 PXA1 Saccharomyces cerevisiae Pxa1p NP_015178.1 273254 D 4932 CDS NP_015179.1 6325111 855957 complement(276161..277528) 1 NC_001148.3 Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p; null mutant is viable but growth is severely impaired; Nop53p 277528 NOP53 855957 NOP53 Saccharomyces cerevisiae Nop53p NP_015179.1 276161 R 4932 CDS NP_015180.1 6325112 855958 complement(278394..279698) 1 NC_001148.3 Member of the oxysterol binding protein family, which includes seven yeast homologs; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; Kes1p 279698 KES1 855958 KES1 Saccharomyces cerevisiae Kes1p NP_015180.1 278394 R 4932 CDS NP_015181.1 6325113 855959 280479..280925 1 NC_001148.3 Poc4p; Chaperone component involved in 20S proteasome assembly; forms a heterodimer with Irc25p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutant is viable, exhibits shortened telomeres 280925 POC4 855959 POC4 Saccharomyces cerevisiae Chaperone component involved in 20S proteasome assembly; forms a heterodimer with Irc25p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutant is viable, exhibits shortened telomeres NP_015181.1 280479 D 4932 CDS NP_015182.1 6325114 855960 join(282121..282139,282665..282969) 1 NC_001148.3 Rpl33ap; N-terminally acetylated ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Bp and has similarity to rat L35a; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable 282969 RPL33A 855960 RPL33A Saccharomyces cerevisiae N-terminally acetylated ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Bp and has similarity to rat L35a; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable NP_015182.1 282121 D 4932 CDS NP_015184.1 6325116 855962 complement(283463..286060) 1 NC_001148.3 Ypl141cp; Putative protein kinase; similar to Kin4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL141C is not an essential gene 286060 855962 YPL141C Saccharomyces cerevisiae Putative protein kinase; similar to Kin4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL141C is not an essential gene NP_015184.1 283463 R 4932 CDS NP_015185.1 6325117 855963 complement(287513..289033) 1 NC_001148.3 Mkk2p; Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p 289033 MKK2 855963 MKK2 Saccharomyces cerevisiae Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p NP_015185.1 287513 R 4932 CDS NP_015186.1 6325118 855964 complement(289668..291050) 1 NC_001148.3 Ume1p; Negative regulator of meiosis, required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p, Wtm2p 291050 UME1 855964 UME1 Saccharomyces cerevisiae Negative regulator of meiosis, required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p, Wtm2p NP_015186.1 289668 R 4932 CDS NP_015187.1 6325119 855965 complement(291365..292426) 1 NC_001148.3 Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein; Spp1p 292426 SPP1 855965 SPP1 Saccharomyces cerevisiae Spp1p NP_015187.1 291365 R 4932 CDS NP_015188.1 6325121 855967 complement(292816..296646) 1 NC_001148.3 Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments; Gip3p 296646 GIP3 855967 GIP3 Saccharomyces cerevisiae Gip3p NP_015188.1 292816 R 4932 CDS NP_015190.1 6325122 855968 297552..298049 1 NC_001148.3 Isu1p; Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable 298049 ISU1 855968 ISU1 Saccharomyces cerevisiae Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable NP_015190.1 297552 D 4932 CDS NP_015191.1 6325123 855969 complement(298570..299502) 1 NC_001148.3 Odc1p; Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation 299502 ODC1 855969 ODC1 Saccharomyces cerevisiae Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation NP_015191.1 298570 R 4932 CDS NP_015192.1 6325124 855970 complement(299887..301227) 1 NC_001148.3 Zinc cluster transcriptional activator involved in conferring resistance to ketoconazole; Rds2p 301227 RDS2 855970 RDS2 Saccharomyces cerevisiae Rds2p NP_015192.1 299887 R 4932 CDS NP_015193.1 6325125 855971 301715..302617 1 NC_001148.3 Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p; Cox11p 302617 COX11 855971 COX11 Saccharomyces cerevisiae Cox11p NP_015193.1 301715 D 4932 CDS NP_015194.1 6325126 855972 303120..304013 1 NC_001148.3 Rpl5p; Protein component of the large (60S) ribosomal subunit with similarity to E. coli L18 and rat L5 ribosomal proteins; binds 5S rRNA and is required for 60S subunit assembly 304013 RPL5 855972 RPL5 Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit with similarity to E. coli L18 and rat L5 ribosomal proteins; binds 5S rRNA and is required for 60S subunit assembly NP_015194.1 303120 D 4932 CDS NP_015195.1 6325127 855973 304386..305057 1 NC_001148.3 Spo19p; Meiosis-specific protein of unknown function, involved in completion of nuclear divisions; identified as a weak high-copy suppressor of the spo1-1 ts mutation; putative GPI-dependent cell-wall protein 305057 SPO19 855973 SPO19 Saccharomyces cerevisiae Meiosis-specific protein of unknown function, involved in completion of nuclear divisions; identified as a weak high-copy suppressor of the spo1-1 ts mutation; putative GPI-dependent cell-wall protein NP_015195.1 304386 D 4932 CDS NP_015196.1 6325128 855974 join(305297..305305,305411..306136) 1 NC_001148.3 Taf14p; Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes, involved in RNA polymerase II transcription initiation and in chromatin modification; contains a YEATS domain 306136 TAF14 855974 TAF14 Saccharomyces cerevisiae Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes, involved in RNA polymerase II transcription initiation and in chromatin modification; contains a YEATS domain NP_015196.1 305297 D 4932 CDS NP_015197.1 6325129 855975 complement(306532..308220) 1 NC_001148.3 Telobox-containing general regulatory factor; binds to TTAGGG repeats within subtelomeric anti-silencing regions (STARs) and possibly throughout the genome and mediates their insulating capacity by blocking silent chromatin propagation; Tbf1p 308220 TBF1 855975 TBF1 Saccharomyces cerevisiae Tbf1p NP_015197.1 306532 R 4932 CDS NP_015198.1 6325130 855976 complement(308827..309603) 1 NC_001148.3 Histone H1, a linker histone required for nucleosome packaging at restricted sites; suppresses DNA repair involving homologous recombination; not required for telomeric silencing, basal transcriptional repression, or efficient sporulation; Hho1p 309603 HHO1 855976 HHO1 Saccharomyces cerevisiae Hho1p NP_015198.1 308827 R 4932 CDS NP_015199.1 6325131 855977 310209..312899 1 NC_001148.3 U3 snoRNP protein, component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNA; Nan1p 312899 NAN1 855977 NAN1 Saccharomyces cerevisiae Nan1p NP_015199.1 310209 D 4932 CDS NP_015200.1 6325132 855978 313387..316485 1 NC_001148.3 Karyopherin with a role in the assembly or export of 60S ribosomal subunits; Kap120p 316485 KAP120 855978 KAP120 Saccharomyces cerevisiae Kap120p NP_015200.1 313387 D 4932 CDS NP_015201.1 6325133 855979 316754..317515 1 NC_001148.3 Spc29p; Inner plaque spindle pole body (SPB) component, links the central plaque component Spc42p to the inner plaque component Spc110p; required for SPB duplication 317515 SPC29 855979 SPC29 Saccharomyces cerevisiae Inner plaque spindle pole body (SPB) component, links the central plaque component Spc42p to the inner plaque component Spc110p; required for SPB duplication NP_015201.1 316754 D 4932 CDS NP_015202.1 6325134 855980 complement(317640..318944) 1 NC_001148.3 Rny1p; RNAse; member of the T(2) family of endoribonucleases 318944 RNY1 855980 RNY1 Saccharomyces cerevisiae RNAse; member of the T(2) family of endoribonucleases NP_015202.1 317640 R 4932 CDS NP_015203.1 6325135 855981 complement(319225..320766) 1 NC_001148.3 Tfb2p; Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH 320766 TFB2 855981 TFB2 Saccharomyces cerevisiae Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH NP_015203.1 319225 R 4932 CDS NP_015204.1 6325136 855982 complement(320961..321629) 1 NC_001148.3 Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p; Mei5p 321629 MEI5 855982 MEI5 Saccharomyces cerevisiae Mei5p NP_015204.1 320961 R 4932 CDS NP_015205.1 6325137 855983 322070..323743 1 NC_001148.3 Vps30p; Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; ortholog of the higher eukaryotic gene Beclin 1 323743 VPS30 855983 VPS30 Saccharomyces cerevisiae Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; ortholog of the higher eukaryotic gene Beclin 1 NP_015205.1 322070 D 4932 CDS NP_878181.1 33438893 1466520 complement(324023..324286) 1 NC_001148.3 Ypl119c-ap; Putative protein of unknown function; identified by expression profiling and mass spectrometry 324286 1466520 YPL119C-A Saccharomyces cerevisiae Putative protein of unknown function; identified by expression profiling and mass spectrometry NP_878181.1 324023 R 4932 CDS NP_015206.1 6325138 855984 complement(324410..326263) 1 NC_001148.3 Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs; Dbp1p 326263 DBP1 855984 DBP1 Saccharomyces cerevisiae Dbp1p NP_015206.1 324410 R 4932 CDS NP_015207.1 6325139 855985 326627..327661 1 NC_001148.3 Mrp51p; Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences 327661 MRP51 855985 MRP51 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences NP_015207.1 326627 D 4932 CDS NP_015208.1 6325140 855986 complement(327863..328729) 1 NC_001148.3 Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase), catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability; Idi1p 328729 IDI1 855986 IDI1 Saccharomyces cerevisiae Idi1p NP_015208.1 327863 R 4932 CDS NP_015209.1 6325141 855987 329605..331698 1 NC_001148.3 Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats; Hos3p 331698 HOS3 855987 HOS3 Saccharomyces cerevisiae Hos3p NP_015209.1 329605 D 4932 CDS NP_015210.1 6325142 855988 complement(332099..335485) 1 NC_001148.3 Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly; Bem3p 335485 BEM3 855988 BEM3 Saccharomyces cerevisiae Bem3p NP_015210.1 332099 R 4932 CDS NP_015212.1 6325144 855990 complement(335952..337142) 1 NC_001148.3 Ypl113cp; Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene 337142 855990 YPL113C Saccharomyces cerevisiae Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene NP_015212.1 335952 R 4932 CDS NP_015213.1 6325145 855991 complement(337435..338619) 1 NC_001148.3 Pex25p; Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p 338619 PEX25 855991 PEX25 Saccharomyces cerevisiae Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p NP_015213.1 337435 R 4932 CDS NP_015214.1 6325146 855993 339943..340944 1 NC_001148.3 Car1p; Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance 340944 CAR1 855993 CAR1 Saccharomyces cerevisiae Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance NP_015214.1 339943 D 4932 CDS NP_015215.1 6325147 855994 complement(341067..344738) 1 NC_001148.3 Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes; Gde1p 344738 GDE1 855994 GDE1 Saccharomyces cerevisiae Gde1p NP_015215.1 341067 R 4932 CDS NP_015216.3 50593504 855995 complement(join(345263..345443,345596..347388)) 1 NC_001148.3 Ypl109cp; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 347388 855995 YPL109C Saccharomyces cerevisiae Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_015216.3 345263 R 4932 CDS NP_015217.1 6325149 855996 348443..348949 1 NC_001148.3 Ypl108wp; Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS 348949 855996 YPL108W Saccharomyces cerevisiae Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS NP_015217.1 348443 D 4932 CDS NP_015218.1 6325150 855997 349116..349862 1 NC_001148.3 Ypl107wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene 349862 855997 YPL107W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene NP_015218.1 349116 D 4932 CDS NP_015219.1 6325151 855998 complement(350191..352272) 1 NC_001148.3 Sse1p; ATPase that is a component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm 352272 SSE1 855998 SSE1 Saccharomyces cerevisiae ATPase that is a component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm NP_015219.1 350191 R 4932 CDS NP_015220.1 6325152 855999 complement(352860..355409) 1 NC_001148.3 Ypl105cp; Protein of unknown function that may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 355409 855999 YPL105C Saccharomyces cerevisiae Protein of unknown function that may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_015220.1 352860 R 4932 CDS NP_015221.1 6325153 856000 355697..357673 1 NC_001148.3 Msd1p; Mitochondrial aspartyl-tRNA synthetase, required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene 357673 MSD1 856000 MSD1 Saccharomyces cerevisiae Mitochondrial aspartyl-tRNA synthetase, required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene NP_015221.1 355697 D 4932 CDS NP_015222.1 6325154 856001 complement(357997..359403) 1 NC_001148.3 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Fmp30p 359403 FMP30 856001 FMP30 Saccharomyces cerevisiae Fmp30p NP_015222.1 357997 R 4932 CDS NP_015224.1 6325155 856002 360206..361576 1 NC_001148.3 Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity; Elp4p 361576 ELP4 856002 ELP4 Saccharomyces cerevisiae Elp4p NP_015224.1 360206 D 4932 CDS NP_015225.1 6325157 856004 361869..363359 1 NC_001148.3 Phosphoinositide binding protein required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein; Atg21p 363359 ATG21 856004 ATG21 Saccharomyces cerevisiae Atg21p NP_015225.1 361869 D 4932 CDS NP_015226.1 6325158 856005 complement(363517..364065) 1 NC_001148.3 Protein of unknown function;non-tagged protein detected in purified mitochondria in high-throughput studies; null mutant displays increased frequency of mitochondrial genome loss and severe growth defect in minimal glycerol media; Aim43p 364065 AIM43 856005 AIM43 Saccharomyces cerevisiae Aim43p NP_015226.1 363517 R 4932 CDS NP_015227.1 6325159 856006 complement(364383..364724) 1 NC_001148.3 Protein required for growth of cells lacking the mitochondrial genome; Mgr2p 364724 MGR2 856006 MGR2 Saccharomyces cerevisiae Mgr2p NP_015227.1 364383 R 4932 CDS NP_015228.1 6325160 856007 364949..366427 1 NC_001148.3 Msy1p; Mitochondrial tyrosyl-tRNA synthetase 366427 MSY1 856007 MSY1 Saccharomyces cerevisiae Mitochondrial tyrosyl-tRNA synthetase NP_015228.1 364949 D 4932 CDS NP_690846.1 23270400 856008 complement(366526..366732) 1 NC_001148.3 Eri1p; Endoplasmic reticulum membrane protein that binds to and inhibits GTP-bound Ras2p at the ER; component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein 366732 ERI1 856008 ERI1 Saccharomyces cerevisiae Endoplasmic reticulum membrane protein that binds to and inhibits GTP-bound Ras2p at the ER; component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein NP_690846.1 366526 R 4932 CDS NP_015229.1 6325161 856009 366924..368015 1 NC_001148.3 Png1p; Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation, localizes to the cytoplasm and nucleus, interacts with the DNA repair protein Rad23p 368015 PNG1 856009 PNG1 Saccharomyces cerevisiae Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation, localizes to the cytoplasm and nucleus, interacts with the DNA repair protein Rad23p NP_015229.1 366924 D 4932 CDS NP_015230.1 6325162 856010 complement(368068..369438) 1 NC_001148.3 Eeb1p; Acyl-coenzymeA:ethanol O-acyltransferase responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short chain esterase activity; may be involved in lipid metabolism and detoxification 369438 EEB1 856010 EEB1 Saccharomyces cerevisiae Acyl-coenzymeA:ethanol O-acyltransferase responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short chain esterase activity; may be involved in lipid metabolism and detoxification NP_015230.1 368068 R 4932 CDS NP_015231.2 41629689 856011 complement(369836..370660) 1 NC_001148.3 Sec62p; Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER 370660 SEC62 856011 SEC62 Saccharomyces cerevisiae Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER NP_015231.2 369836 R 4932 CDS NP_015232.1 6325164 856012 370975..372918 1 NC_001148.3 Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins; Nog1p 372918 NOG1 856012 NOG1 Saccharomyces cerevisiae Nog1p NP_015232.1 370975 D 4932 CDS NP_015233.1 6325165 856013 373790..375166 1 NC_001148.3 Ssu1p; Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein 375166 SSU1 856013 SSU1 Saccharomyces cerevisiae Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein NP_015233.1 373790 D 4932 CDS NP_015234.1 6325166 856014 375499..376950 1 NC_001148.3 Glr1p; Cytosolic and mitochondrial glutathione oxidoreductase, converts oxidized glutathione to reduced glutathione 376950 GLR1 856014 GLR1 Saccharomyces cerevisiae Cytosolic and mitochondrial glutathione oxidoreductase, converts oxidized glutathione to reduced glutathione NP_015234.1 375499 D 4932 CDS NP_015235.1 6325167 856015 complement(join(377288..377992,378387..378392)) 1 NC_001148.3 Rps6ap; Protein component of the small (40S) ribosomal subunit; identical to Rps6Bp and has similarity to rat S6 ribosomal protein 378392 RPS6A 856015 RPS6A Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit; identical to Rps6Bp and has similarity to rat S6 ribosomal protein NP_015235.1 377288 R 4932 CDS NP_015236.1 6325168 856016 complement(379117..381147) 1 NC_001148.3 Rlm1p; MADS-box transcription factor, component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p 381147 RLM1 856016 RLM1 Saccharomyces cerevisiae MADS-box transcription factor, component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p NP_015236.1 379117 R 4932 CDS NP_015237.1 6325169 856017 381962..382990 1 NC_001148.3 Ypl088wp; Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance 382990 856017 YPL088W Saccharomyces cerevisiae Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance NP_015237.1 381962 D 4932 CDS NP_015238.1 6325170 856018 383452..384405 1 NC_001148.3 Ydc1p; Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity 384405 YDC1 856018 YDC1 Saccharomyces cerevisiae Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity NP_015238.1 383452 D 4932 CDS NP_015239.1 6325171 856019 complement(384770..386443) 1 NC_001148.3 Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin; Elp3p 386443 ELP3 856019 ELP3 Saccharomyces cerevisiae Elp3p NP_015239.1 384770 R 4932 CDS NP_015240.1 6325172 856020 387064..393651 1 NC_001148.3 Sec16p; COPII vesicle coat protein required for ER transport vesicle budding and autophagosome formation; Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p 393651 SEC16 856020 SEC16 Saccharomyces cerevisiae COPII vesicle coat protein required for ER transport vesicle budding and autophagosome formation; Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p NP_015240.1 387064 D 4932 CDS NP_015241.1 6325173 856021 394035..396569 1 NC_001148.3 Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes; Bro1p 396569 BRO1 856021 BRO1 Saccharomyces cerevisiae Bro1p NP_015241.1 394035 D 4932 CDS NP_015242.1 6325174 856022 complement(396699..398102) 1 NC_001148.3 Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen54p 398102 SEN54 856022 SEN54 Saccharomyces cerevisiae Sen54p NP_015242.1 396699 R 4932 CDS NP_015243.1 6325175 856023 complement(398477..404080) 1 NC_001148.3 Mot1p; Essential abundant protein involved in regulation of transcription, removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity 404080 MOT1 856023 MOT1 Saccharomyces cerevisiae Essential abundant protein involved in regulation of transcription, removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity NP_015243.1 398477 R 4932 CDS NP_015244.1 6325176 856024 join(404947..404953,405455..406041) 1 NC_001148.3 Rps9ap; Protein component of the small (40S) ribosomal subunit; nearly identical to Rps9Bp and has similarity to E. coli S4 and rat S9 ribosomal proteins 406041 RPS9A 856024 RPS9A Saccharomyces cerevisiae Protein component of the small (40S) ribosomal subunit; nearly identical to Rps9Bp and has similarity to E. coli S4 and rat S9 ribosomal proteins NP_015244.1 404947 D 4932 CDS NP_015246.1 6325178 856026 join(406633..406643,407065..407536) 1 NC_001148.3 Rpl21bp; Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Ap and has similarity to rat L21 ribosomal protein 407536 RPL21B 856026 RPL21B Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Ap and has similarity to rat L21 ribosomal protein NP_015246.1 406633 D 4932 CDS NP_015247.1 6325179 856027 complement(408007..408741) 1 NC_001148.3 Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated; Atp4p 408741 ATP4 856027 ATP4 Saccharomyces cerevisiae Atp4p NP_015247.1 408007 R 4932 CDS NP_015248.1 6325180 856028 complement(409365..410087) 1 NC_001148.3 Ypl077cp; Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene 410087 856028 YPL077C Saccharomyces cerevisiae Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene NP_015248.1 409365 R 4932 CDS NP_015249.1 6325181 856029 410440..411282 1 NC_001148.3 Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein; Gpi2p 411282 GPI2 856029 GPI2 Saccharomyces cerevisiae Gpi2p NP_015249.1 410440 D 4932 CDS NP_015250.1 6325182 856030 join(412251..412258,413010..415359) 1 NC_001148.3 Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p; Gcr1p 415359 GCR1 856030 GCR1 Saccharomyces cerevisiae Gcr1p NP_015250.1 412251 D 4932 CDS NP_015251.1 6325183 856031 415760..418024 1 NC_001148.3 Yta6p; Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family, localized to the cortex of mother cells but not to daughter cells 418024 YTA6 856031 YTA6 Saccharomyces cerevisiae Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family, localized to the cortex of mother cells but not to daughter cells NP_015251.1 415760 D 4932 CDS NP_015253.1 6325184 856032 418509..420008 1 NC_001148.3 Ubp16p; Deubiquitinating enzyme anchored to the outer mitochondrial membrane, probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria 420008 UBP16 856032 UBP16 Saccharomyces cerevisiae Deubiquitinating enzyme anchored to the outer mitochondrial membrane, probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria NP_015253.1 418509 D 4932 CDS NP_015254.1 6325186 856034 complement(420045..420515) 1 NC_001148.3 Ypl071cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus 420515 856034 YPL071C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus NP_015254.1 420045 R 4932 CDS NP_015255.1 6325187 856035 420945..422783 1 NC_001148.3 Muk1p; Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation 422783 MUK1 856035 MUK1 Saccharomyces cerevisiae Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation NP_015255.1 420945 D 4932 CDS NP_015256.1 6325188 856036 complement(422882..423889) 1 NC_001148.3 Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic; Bts1p 423889 BTS1 856036 BTS1 Saccharomyces cerevisiae Bts1p NP_015256.1 422882 R 4932 CDS NP_015257.1 6325189 856037 complement(424212..425093) 1 NC_001148.3 Ypl068cp; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and is induced in response to the DNA-damaging agent MMS 425093 856037 YPL068C Saccharomyces cerevisiae Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and is induced in response to the DNA-damaging agent MMS NP_015257.1 424212 R 4932 CDS NP_015258.1 6325190 856038 complement(425248..425844) 1 NC_001148.3 Ypl067cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene 425844 856038 YPL067C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene NP_015258.1 425248 R 4932 CDS NP_015259.1 6325191 856039 426230..427669 1 NC_001148.3 Ypl066wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source 427669 856039 YPL066W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source NP_015259.1 426230 D 4932 CDS NP_015260.1 6325192 856040 427924..428652 1 NC_001148.3 Vps28p; Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; involved in transport of precursors for soluble vacuolar hydrolases from the late endosome to the vacuole 428652 VPS28 856040 VPS28 Saccharomyces cerevisiae Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; involved in transport of precursors for soluble vacuolar hydrolases from the late endosome to the vacuole NP_015260.1 427924 D 4932 CDS NP_015261.1 6325193 856041 complement(428708..429613) 1 NC_001148.3 Cwc27p; Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p 429613 CWC27 856041 CWC27 Saccharomyces cerevisiae Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p NP_015261.1 428708 R 4932 CDS NP_015262.1 6325194 856042 429936..431366 1 NC_001148.3 Tim50p; Constituent of the mitochondrial inner membrane presequence translocase (TIM23 complex); may promote binding of incoming precursor proteins to the intermembrane space domain of Tom22p during translocation 431366 TIM50 856042 TIM50 Saccharomyces cerevisiae Constituent of the mitochondrial inner membrane presequence translocase (TIM23 complex); may promote binding of incoming precursor proteins to the intermembrane space domain of Tom22p during translocation NP_015262.1 429936 D 4932 CDS NP_015264.1 6325196 856044 432585..434087 1 NC_001148.3 Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress; Ald6p 434087 ALD6 856044 ALD6 Saccharomyces cerevisiae Ald6p NP_015264.1 432585 D 4932 CDS NP_015265.1 6325197 856045 434520..435761 1 NC_001148.3 Mitochondrial inner membrane magnesium transporter, involved in maintenance of magnesium concentrations inside mitochondria; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p; Lpe10p 435761 LPE10 856045 LPE10 Saccharomyces cerevisiae Lpe10p NP_015265.1 434520 D 4932 CDS NP_015266.1 6325198 856048 444576..445028 1 NC_001148.3 Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; mitochondrial matrix protein involved in the synthesis/assembly of iron-sulfur centers; monothiol glutaredoxin subfamily member along with Grx3p and Grx4p; Grx5p 445028 GRX5 856048 GRX5 Saccharomyces cerevisiae Grx5p NP_015266.1 444576 D 4932 CDS NP_015267.1 6325199 856049 complement(445839..450374) 1 NC_001148.3 Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity; Pdr12p 450374 PDR12 856049 PDR12 Saccharomyces cerevisiae Pdr12p NP_015267.1 445839 R 4932 CDS NP_015268.1 6325200 856050 complement(451906..453054) 1 NC_001148.3 Sur1p; Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p 453054 SUR1 856050 SUR1 Saccharomyces cerevisiae Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p NP_015268.1 451906 R 4932 CDS NP_015269.1 6325201 856051 complement(453427..453732) 1 NC_001148.3 Ypl056cp; Putative protein of unknown function; deletion mutant is fluconazole resistant 453732 856051 YPL056C Saccharomyces cerevisiae Putative protein of unknown function; deletion mutant is fluconazole resistant NP_015269.1 453427 R 4932 CDS NP_015270.1 6325202 856052 complement(453989..454987) 1 NC_001148.3 Protein of unknown function; null mutant forms abnormally large cells; Lge1p 454987 LGE1 856052 LGE1 Saccharomyces cerevisiae Lge1p NP_015270.1 453989 R 4932 CDS NP_015271.1 6325203 856053 455756..456661 1 NC_001148.3 Zinc-finger protein of unknown function; Lee1p 456661 LEE1 856053 LEE1 Saccharomyces cerevisiae Lee1p NP_015271.1 455756 D 4932 CDS NP_015272.1 6325204 856054 complement(457115..458455) 1 NC_001148.3 Probable mannosylphosphate transferase involved in the synthesis of core oligosaccharides in protein glycosylation pathway; member of the KRE2/MNT1 mannosyltransferase family; Ktr6p 458455 KTR6 856054 KTR6 Saccharomyces cerevisiae Ktr6p NP_015272.1 457115 R 4932 CDS NP_015273.2 83722566 856055 join(458796..459002,459004..459675) 1 NC_001148.3 Regulator of ornithine decarboxylase (Spe1p), antizyme that binds to Spe1p to regulate ubiquitin-independent degradation; ribosomal frameshifting during synthesis of Oaz1p and its ubiquitin-mediated degradation are both polyamine-regulated; Oaz1p 459675 OAZ1 856055 OAZ1 Saccharomyces cerevisiae Oaz1p NP_015273.2 458796 D 4932 CDS NP_015274.1 6325206 856056 459960..460556 1 NC_001148.3 GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor; Arl3p 460556 ARL3 856056 ARL3 Saccharomyces cerevisiae Arl3p NP_015274.1 459960 D 4932 CDS NP_015275.1 6325207 856057 complement(460776..461963) 1 NC_001148.3 Subunit of Golgi mannosyltransferase complex also containing Anp1p, Mnn10p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; forms a separate complex with Van1p that is also involved in backbone elongation; Mnn9p 461963 MNN9 856057 MNN9 Saccharomyces cerevisiae Mnn9p NP_015275.1 460776 R 4932 CDS NP_015276.1 6325208 856058 complement(462478..463836) 1 NC_001148.3 Regulatory protein of unknown function, constitutively-expressed, involved in the regulation of mating-specific genes and the invasive growth pathway, required for MAP-kinase imposed repression, inhibits pheromone-responsive transcription; Dig1p 463836 DIG1 856058 DIG1 Saccharomyces cerevisiae Dig1p NP_015276.1 462478 R 4932 CDS NP_015277.1 6325209 856059 464398..465645 1 NC_001148.3 Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma; Cam1p 465645 CAM1 856059 CAM1 Saccharomyces cerevisiae Cam1p NP_015277.1 464398 D 4932 CDS NP_015278.1 6325210 856060 465959..466258 1 NC_001148.3 Sgf11p; Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation 466258 SGF11 856060 SGF11 Saccharomyces cerevisiae Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation NP_015278.1 465959 D 4932 CDS NP_015279.1 6325211 856061 complement(466641..466940) 1 NC_001148.3 Elongin C, forms heterodimer with Ela1p that participates in transcription elongation; required for ubiquitin-dependent degradation of the RNA Polymerase II subunit RPO21; expression dramatically upregulated during sporulation; Elc1p 466940 ELC1 856061 ELC1 Saccharomyces cerevisiae Elc1p NP_015279.1 466641 R 4932 CDS NP_015280.1 6325212 856062 467257..469653 1 NC_001148.3 Vps16p; Subunit of the vacuole fusion and protein sorting HOPS complex and the CORVET tethering complex; part of the Class C Vps complex essential for membrane docking and fusion at Golgi-to-endosome and endosome-to-vacuole protein transport stages 469653 VPS16 856062 VPS16 Saccharomyces cerevisiae Subunit of the vacuole fusion and protein sorting HOPS complex and the CORVET tethering complex; part of the Class C Vps complex essential for membrane docking and fusion at Golgi-to-endosome and endosome-to-vacuole protein transport stages NP_015280.1 467257 D 4932 CDS NP_015282.1 6325213 856063 469936..471993 1 NC_001148.3 Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs); Nop4p 471993 NOP4 856063 NOP4 Saccharomyces cerevisiae Nop4p NP_015282.1 469936 D 4932 CDS NP_015283.1 6325215 856065 complement(473037..474704) 1 NC_001148.3 Ssn3p; Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression 474704 SSN3 856065 SSN3 Saccharomyces cerevisiae Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression NP_015283.1 473037 R 4932 CDS NP_015284.1 6325216 856066 complement(475115..475738) 1 NC_001148.3 Ypl041cp; Protein of unknown function involved in maintenance of proper telomere length 475738 856066 YPL041C Saccharomyces cerevisiae Protein of unknown function involved in maintenance of proper telomere length NP_015284.1 475115 R 4932 CDS NP_015285.1 6325217 856067 complement(475990..478998) 1 NC_001148.3 Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth; Ism1p 478998 ISM1 856067 ISM1 Saccharomyces cerevisiae Ism1p NP_015285.1 475990 R 4932 CDS NP_015286.1 6325218 856068 479222..480172 1 NC_001148.3 Ypl039wp; Putative protein of unknown function; YPL039W is not an essential gene 480172 856068 YPL039W Saccharomyces cerevisiae Putative protein of unknown function; YPL039W is not an essential gene NP_015286.1 479222 D 4932 CDS NP_878182.1 33438894 1466521 480179..480370 1 NC_001148.3 Ypl038w-ap; Putative protein of unknown function; identified by fungal homology and RT-PCR 480370 1466521 YPL038W-A Saccharomyces cerevisiae Putative protein of unknown function; identified by fungal homology and RT-PCR NP_878182.1 480179 D 4932 CDS NP_015287.1 6325219 856069 480532..481065 1 NC_001148.3 Zinc-finger DNA-binding protein, involved in transcriptional regulation of the methionine biosynthetic genes, similar to Met32p; Met31p 481065 MET31 856069 MET31 Saccharomyces cerevisiae Met31p NP_015287.1 480532 D 4932 CDS NP_015288.1 6325220 856070 complement(481425..481898) 1 NC_001148.3 Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b; Egd1p 481898 EGD1 856070 EGD1 Saccharomyces cerevisiae Egd1p NP_015288.1 481425 R 4932 CDS NP_015289.1 6325221 856071 482841..485684 1 NC_001148.3 Pma2p; Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential 485684 PMA2 856071 PMA2 Saccharomyces cerevisiae Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential NP_015289.1 482841 D 4932 CDS NP_015291.1 6325222 856072 486710..487207 1 NC_001148.3 Ypl034wp; Putative protein of unknown function; YPL034W is not essential gene 487207 856072 YPL034W Saccharomyces cerevisiae Putative protein of unknown function; YPL034W is not essential gene NP_015291.1 486710 D 4932 CDS NP_015292.1 6325224 856074 complement(487360..488205) 1 NC_001148.3 Ypl033cp; Putative protein of unknown function; may be involved in DNA metabolism; expression is induced by Kar4p 488205 856074 YPL033C Saccharomyces cerevisiae Putative protein of unknown function; may be involved in DNA metabolism; expression is induced by Kar4p NP_015292.1 487360 R 4932 CDS NP_015293.1 6325225 856075 complement(488885..491362) 1 NC_001148.3 Svl3p; Protein of unknown function, mutant phenotype suggests a potential role in vacuolar function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck 491362 SVL3 856075 SVL3 Saccharomyces cerevisiae Protein of unknown function, mutant phenotype suggests a potential role in vacuolar function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck NP_015293.1 488885 R 4932 CDS NP_015294.1 6325226 856076 complement(join(492016..492916,493019..493035)) 1 NC_001148.3 Pho85p; Cyclin-dependent kinase, with ten cyclin partners; involved in environmental stress response; in phosphate-rich conditions, Pho85p-Pho80p complex phosphorylates Pho4p which in turn represses PHO5 493035 PHO85 856076 PHO85 Saccharomyces cerevisiae Cyclin-dependent kinase, with ten cyclin partners; involved in environmental stress response; in phosphate-rich conditions, Pho85p-Pho80p complex phosphorylates Pho4p which in turn represses PHO5 NP_015294.1 492016 R 4932 CDS NP_015295.1 6325227 856077 493541..495244 1 NC_001148.3 Trm44p; Putative tRNA U44 2'-O-methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; non-essential gene 495244 TRM44 856077 TRM44 Saccharomyces cerevisiae Putative tRNA U44 2'-O-methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; non-essential gene NP_015295.1 493541 D 4932 CDS NP_015296.1 6325228 856078 495504..497717 1 NC_001148.3 Suv3p; ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs 497717 SUV3 856078 SUV3 Saccharomyces cerevisiae ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs NP_015296.1 495504 D 4932 CDS NP_015297.1 6325229 856079 498094..499290 1 NC_001148.3 Erg10p; Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis 499290 ERG10 856079 ERG10 Saccharomyces cerevisiae Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis NP_015297.1 498094 D 4932 CDS NP_015298.1 6325230 856080 499663..500400 1 NC_001148.3 Sma1p; Protein of unknown function involved in the assembly of the prospore membrane during sporulation 500400 SMA1 856080 SMA1 Saccharomyces cerevisiae Protein of unknown function involved in the assembly of the prospore membrane during sporulation NP_015298.1 499663 D 4932 CDS NP_015299.1 6325231 856081 complement(500673..502181) 1 NC_001148.3 Sks1p; Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway 502181 SKS1 856081 SKS1 Saccharomyces cerevisiae Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway NP_015299.1 500673 R 4932 CDS NP_015301.1 6325233 856083 503515..504240 1 NC_001148.3 Rmi1p; Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III) 504240 RMI1 856083 RMI1 Saccharomyces cerevisiae Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III) NP_015301.1 503515 D 4932 CDS NP_015302.1 6325234 856084 complement(504337..506310) 1 NC_001148.3 Met12p; Isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway 506310 MET12 856084 MET12 Saccharomyces cerevisiae Isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway NP_015302.1 504337 R 4932 CDS NP_015303.1 6325235 856085 506695..509997 1 NC_001148.3 Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein; Rad1p 509997 RAD1 856085 RAD1 Saccharomyces cerevisiae Rad1p NP_015303.1 506695 D 4932 CDS NP_015304.1 6325236 856086 511099..511662 1 NC_001148.3 Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p; Ecm23p 511662 ECM23 856086 ECM23 Saccharomyces cerevisiae Ecm23p NP_015304.1 511099 D 4932 CDS NP_015305.1 6325237 856087 complement(512311..514176) 1 NC_001148.3 Ulp1p; Ubl (ubiquitin-like protein)-specific protease that cleaves Smt3p protein conjugates; specifically required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase 514176 ULP1 856087 ULP1 Saccharomyces cerevisiae Ubl (ubiquitin-like protein)-specific protease that cleaves Smt3p protein conjugates; specifically required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase NP_015305.1 512311 R 4932 CDS NP_015306.1 6325238 856088 complement(514509..517016) 1 NC_001148.3 Vtc3p; Vacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in non-autophagic vacuolar fusion 517016 VTC3 856088 VTC3 Saccharomyces cerevisiae Vacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in non-autophagic vacuolar fusion NP_015306.1 514509 R 4932 CDS NP_015307.1 6325239 856089 517649..518758 1 NC_001148.3 Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly; Ctf19p 518758 CTF19 856089 CTF19 Saccharomyces cerevisiae Ctf19p NP_015307.1 517649 D 4932 CDS NP_015308.1 6325240 856090 complement(518732..520231) 1 NC_001148.3 Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; null mutant displays increased levels of spontaneous Rad52 foci; Irc15p 520231 IRC15 856090 IRC15 Saccharomyces cerevisiae Irc15p NP_015308.1 518732 R 4932 CDS NP_015309.1 6325241 856091 521011..524955 1 NC_001148.3 Swi1p; Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2 524955 SWI1 856091 SWI1 Saccharomyces cerevisiae Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2 NP_015309.1 521011 D 4932 CDS NP_015310.1 6325242 856092 complement(525807..526880) 1 NC_001148.3 Hst2p; Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro 526880 HST2 856092 HST2 Saccharomyces cerevisiae Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro NP_015310.1 525807 R 4932 CDS NP_015311.1 6325243 856093 527544..528689 1 NC_001148.3 Ypl014wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus 528689 856093 YPL014W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus NP_015311.1 527544 D 4932 CDS NP_015312.1 6325244 856094 complement(528982..529347) 1 NC_001148.3 Mrps16p; Mitochondrial ribosomal protein of the small subunit 529347 MRPS16 856094 MRPS16 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the small subunit NP_015312.1 528982 R 4932 CDS NP_015313.1 6325245 856095 529720..533406 1 NC_001148.3 Rrp12p; Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; contains HEAT-repeats 533406 RRP12 856095 RRP12 Saccharomyces cerevisiae Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; contains HEAT-repeats NP_015313.1 529720 D 4932 CDS NP_015314.1 6325246 856096 complement(533639..534700) 1 NC_001148.3 Taf3p; TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation 534700 TAF3 856096 TAF3 Saccharomyces cerevisiae TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation NP_015314.1 533639 R 4932 CDS NP_015315.1 6325247 856097 535015..535584 1 NC_001148.3 Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER; Ret3p 535584 RET3 856097 RET3 Saccharomyces cerevisiae Ret3p NP_015315.1 535015 D 4932 CDS NP_015316.1 6325248 856098 complement(535817..538933) 1 NC_001148.3 Ypl009cp; Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL009C is not an essential gene 538933 856098 YPL009C Saccharomyces cerevisiae Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL009C is not an essential gene NP_015316.1 535817 R 4932 CDS NP_015317.1 6325249 856099 539382..541967 1 NC_001148.3 Conserved nuclear protein required to establish sister-chromatid pairing during S-phase, probable DNA helicase with similarity to human BACH1, which associates with tumor suppressor BRCA1; associates with acetyltransferase Ctf7p; Chl1p 541967 CHL1 856099 CHL1 Saccharomyces cerevisiae Chl1p NP_015317.1 539382 D 4932 CDS NP_015318.1 6325250 856100 complement(542079..543845) 1 NC_001148.3 Tfc8p; One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90 543845 TFC8 856100 TFC8 Saccharomyces cerevisiae One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90 NP_015318.1 542079 R 4932 CDS NP_015319.1 6325251 856101 544628..548140 1 NC_001148.3 Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; glycoprotein and functional orthologue of human Niemann Pick C1 (NPC1) protein; Ncr1p 548140 NCR1 856101 NCR1 Saccharomyces cerevisiae Ncr1p NP_015319.1 544628 D 4932 CDS NP_015320.1 6325252 856102 548483..550303 1 NC_001148.3 Peripheral mitochondrial inner membrane protein, located on the matrix face of the membrane; stabilizes the bicistronic AAP1-ATP6 mRNA encoding subunits 6 and 8 of the ATP synthase complex; Aep3p 550303 AEP3 856102 AEP3 Saccharomyces cerevisiae Aep3p NP_015320.1 548483 D 4932 CDS NP_015321.1 6325253 856103 complement(550629..551654) 1 NC_001148.3 Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; Lsp1p 551654 LSP1 856103 LSP1 Saccharomyces cerevisiae Lsp1p NP_015321.1 550629 R 4932 CDS NP_015322.1 6325254 856104 552017..553405 1 NC_001148.3 Ula1p; Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation 553405 ULA1 856104 ULA1 Saccharomyces cerevisiae Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation NP_015322.1 552017 D 4932 CDS NP_015323.1 6325255 856105 complement(553624..554325) 1 NC_001148.3 Snf8p; Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression 554325 SNF8 856105 SNF8 Saccharomyces cerevisiae Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression NP_015323.1 553624 R 4932 CDS NP_015324.1 6325256 856106 554602..555726 1 NC_001148.3 Hat1p; Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair 555726 HAT1 856106 HAT1 Saccharomyces cerevisiae Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair NP_015324.1 554602 D 4932 CDS NP_015325.1 6325257 856107 556374..557834 1 NC_001148.3 Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate; Cit3p 557834 CIT3 856107 CIT3 Saccharomyces cerevisiae Cit3p NP_015325.1 556374 D 4932 CDS NP_015326.1 6325258 856108 558382..559932 1 NC_001148.3 Pdh1p; Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate 559932 PDH1 856108 PDH1 Saccharomyces cerevisiae Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate NP_015326.1 558382 D 4932 CDS NP_015328.1 6325260 856111 complement(561501..563765) 1 NC_001148.3 Ypr003cp; Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene 563765 856111 YPR003C Saccharomyces cerevisiae Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene NP_015328.1 561501 R 4932 CDS NP_015329.1 6325261 856112 complement(564004..565038) 1 NC_001148.3 Protein with similarity to mammalian electron transfer flavoprotein complex subunit ETF-alpha; interacts with yeast frataxin Yfh1p; null mutant displays increased frequency of mitochondrial genome loss (petite formation); Aim45p 565038 AIM45 856112 AIM45 Saccharomyces cerevisiae Aim45p NP_015329.1 564004 R 4932 CDS NP_015330.1 6325262 856113 complement(565784..566668) 1 NC_001148.3 Hal1p; Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p 566668 HAL1 856113 HAL1 Saccharomyces cerevisiae Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p NP_015330.1 565784 R 4932 CDS NP_015331.1 6325263 856114 complement(567266..568993) 1 NC_001148.3 Icl2p; 2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol 568993 ICL2 856114 ICL2 Saccharomyces cerevisiae 2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol NP_015331.1 567266 R 4932 CDS NP_015332.1 6325264 856115 complement(569333..571375) 1 NC_001148.3 Rec8p; Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p 571375 REC8 856115 REC8 Saccharomyces cerevisiae Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p NP_015332.1 569333 R 4932 CDS NP_015333.1 6325265 856117 573015..575099 1 NC_001148.3 Transcriptional activator involved in the transcription of TPO2, HSP30 and other genes encoding membrane stress proteins; involved in adaptation to weak acid stress; Haa1p 575099 HAA1 856117 HAA1 Saccharomyces cerevisiae Haa1p NP_015333.1 573015 D 4932 CDS NP_015334.1 6325266 856118 576549..577355 1 NC_001148.3 Sut2p; Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p 577355 SUT2 856118 SUT2 Saccharomyces cerevisiae Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p NP_015334.1 576549 D 4932 CDS NP_015335.1 6325267 856119 complement(577582..581193) 1 NC_001148.3 Rpa135p; RNA polymerase I subunit A135 581193 RPA135 856119 RPA135 Saccharomyces cerevisiae RNA polymerase I subunit A135 NP_015335.1 577582 R 4932 CDS NP_001091638.1 147921768 5142379 complement(join(582370..582555,582699..582731)) 1 NC_001148.3 Ypr010c-ap; Putative protein of unknown function; conserved among Saccharomyces sensu stricto species 582731 5142379 YPR010C-A Saccharomyces cerevisiae Putative protein of unknown function; conserved among Saccharomyces sensu stricto species NP_001091638.1 582370 R 4932 CDS NP_015336.1 6325268 856121 complement(583059..584039) 1 NC_001148.3 Ypr011cp; Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 584039 856121 YPR011C Saccharomyces cerevisiae Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_015336.1 583059 R 4932 CDS NP_015338.1 6325270 856123 complement(584629..585582) 1 NC_001148.3 Ypr013cp; Putative zinc finger protein; YPR013C is not an essential gene 585582 856123 YPR013C Saccharomyces cerevisiae Putative zinc finger protein; YPR013C is not an essential gene NP_015338.1 584629 R 4932 CDS NP_015340.1 6325272 856125 complement(590280..591023) 1 NC_001148.3 Ypr015cp; Putative protein of unknown function 591023 856125 YPR015C Saccharomyces cerevisiae Putative protein of unknown function NP_015340.1 590280 R 4932 CDS NP_015341.1 6325273 856126 complement(592329..593066) 1 NC_001148.3 Tif6p; Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits 593066 TIF6 856126 TIF6 Saccharomyces cerevisiae Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits NP_015341.1 592329 R 4932 CDS NP_015342.1 6325274 856128 complement(593483..593914) 1 NC_001148.3 Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol; Dss4p 593914 DSS4 856128 DSS4 Saccharomyces cerevisiae Dss4p NP_015342.1 593483 R 4932 CDS NP_015343.1 6325275 856129 594473..596293 1 NC_001148.3 Rlf2p; Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) with Cac2p and Msi1p that assembles newly synthesized histones onto recently replicated DNA; involved in the maintenance of transcriptionally silent chromatin 596293 RLF2 856129 RLF2 Saccharomyces cerevisiae Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) with Cac2p and Msi1p that assembles newly synthesized histones onto recently replicated DNA; involved in the maintenance of transcriptionally silent chromatin NP_015343.1 594473 D 4932 CDS NP_015344.1 6325276 856130 596747..599548 1 NC_001148.3 Mcm4p; Essential helicase component of heterohexameric MCM2-7 complexes which bind pre-replication complexes on DNA and melt the DNA prior to replication; accumulates in the nucleus in G1; homolog of S. pombe Cdc21p 599548 MCM4 856130 MCM4 Saccharomyces cerevisiae Essential helicase component of heterohexameric MCM2-7 complexes which bind pre-replication complexes on DNA and melt the DNA prior to replication; accumulates in the nucleus in G1; homolog of S. pombe Cdc21p NP_015344.1 596747 D 4932 CDS NP_015345.1 6325277 856131 599867..600214 1 NC_001148.3 Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex; Atp20p 600214 ATP20 856131 ATP20 Saccharomyces cerevisiae Atp20p NP_015345.1 599867 D 4932 CDS NP_015346.1 6325278 856132 complement(600646..603354) 1 NC_001148.3 Mitochondrial amino acid transporter, acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis; Agc1p 603354 AGC1 856132 AGC1 Saccharomyces cerevisiae Agc1p NP_015346.1 600646 R 4932 CDS NP_015347.1 6325279 856133 complement(603908..607309) 1 NC_001148.3 Ypr022cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS 607309 856133 YPR022C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS NP_015347.1 603908 R 4932 CDS NP_015348.1 6325280 856134 complement(608823..610028) 1 NC_001148.3 Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; Eaf3p 610028 EAF3 856134 EAF3 Saccharomyces cerevisiae Eaf3p NP_015348.1 608823 R 4932 CDS NP_015349.1 6325281 856135 610478..612721 1 NC_001148.3 Yme1p; Subunit, with Mgr1p, of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; mutation causes an elevated rate of mitochondrial turnover 612721 YME1 856135 YME1 Saccharomyces cerevisiae Subunit, with Mgr1p, of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; mutation causes an elevated rate of mitochondrial turnover NP_015349.1 610478 D 4932 CDS NP_015350.1 6325282 856136 complement(613374..614555) 1 NC_001148.3 Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters; Ccl1p 614555 CCL1 856136 CCL1 Saccharomyces cerevisiae Ccl1p NP_015350.1 613374 R 4932 CDS NP_015351.1 6325283 856137 615376..619011 1 NC_001148.3 Ath1p; Acid trehalase required for utilization of extracellular trehalose 619011 ATH1 856137 ATH1 Saccharomyces cerevisiae Acid trehalase required for utilization of extracellular trehalose NP_015351.1 615376 D 4932 CDS NP_015352.1 6325284 856138 complement(620422..621255) 1 NC_001148.3 Ypr027cp; Putative protein of unknown function 621255 856138 YPR027C Saccharomyces cerevisiae Putative protein of unknown function NP_015352.1 620422 R 4932 CDS NP_015353.1 6325285 856140 join(623524..623574,623708..624199) 1 NC_001148.3 Yop1p; Membrane protein that interacts with Yip1p to mediate membrane traffic; overexpression results in cell death and accumulation of internal cell membranes; regulates vesicular traffic in stressed cells 624199 YOP1 856140 YOP1 Saccharomyces cerevisiae Membrane protein that interacts with Yip1p to mediate membrane traffic; overexpression results in cell death and accumulation of internal cell membranes; regulates vesicular traffic in stressed cells NP_015353.1 623524 D 4932 CDS NP_015354.1 6325286 856141 complement(624466..626964) 1 NC_001148.3 Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport; Apl4p 626964 APL4 856141 APL4 Saccharomyces cerevisiae Apl4p NP_015354.1 624466 R 4932 CDS NP_015355.1 6325287 856142 627877..631242 1 NC_001148.3 Nuclear protein with a potential regulatory role in utilization of galactose and nonfermentable carbon sources; overproduction suppresses the lethality at high temperature of a chs5 spa2 double null mutation; potential Cdc28p substrate; Csr2p 631242 CSR2 856142 CSR2 Saccharomyces cerevisiae Csr2p NP_015355.1 627877 D 4932 CDS NP_015356.1 6325288 856143 631512..633758 1 NC_001148.3 Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3; Nto1p 633758 NTO1 856143 NTO1 Saccharomyces cerevisiae Nto1p NP_015356.1 631512 D 4932 CDS NP_015357.1 6325289 856144 634120..637221 1 NC_001148.3 Sro7p; Putative effector of Rab GTPase Sec4p, forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Sro77p and Drosophila lgl tumor suppressor 637221 SRO7 856144 SRO7 Saccharomyces cerevisiae Putative effector of Rab GTPase Sec4p, forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Sro77p and Drosophila lgl tumor suppressor NP_015357.1 634120 D 4932 CDS NP_015358.1 6325290 856145 complement(637376..639016) 1 NC_001148.3 Hts1p; Cytoplasmic and mitochondrial histidine tRNA synthetase; encoded by a single nuclear gene that specifies two messages; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence 639016 HTS1 856145 HTS1 Saccharomyces cerevisiae Cytoplasmic and mitochondrial histidine tRNA synthetase; encoded by a single nuclear gene that specifies two messages; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence NP_015358.1 637376 R 4932 CDS NP_015359.1 6325291 856146 639522..640955 1 NC_001148.3 Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation; Arp7p 640955 ARP7 856146 ARP7 Saccharomyces cerevisiae Arp7p NP_015359.1 639522 D 4932 CDS NP_015360.1 6325292 856147 642205..643317 1 NC_001148.3 Glutamine synthetase (GS), synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation; Gln1p 643317 GLN1 856147 GLN1 Saccharomyces cerevisiae Gln1p NP_015360.1 642205 D 4932 CDS NP_015361.1 6325293 856148 643833..645269 1 NC_001148.3 Vma13p; Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase 645269 VMA13 856148 VMA13 Saccharomyces cerevisiae Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase NP_015361.1 643833 D 4932 CDS NP_690847.1 23270401 856149 645947..646150 1 NC_001148.3 Ypr036w-ap; Protein of unknown function; transcription is regulated by Pdr1p 646150 856149 YPR036W-A Saccharomyces cerevisiae Protein of unknown function; transcription is regulated by Pdr1p NP_690847.1 645947 D 4932 CDS NP_015362.1 6325296 856152 complement(646445..647035) 1 NC_001148.3 Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER; Erv2p 647035 ERV2 856152 ERV2 Saccharomyces cerevisiae Erv2p NP_015362.1 646445 R 4932 CDS NP_015365.1 6325297 856153 647302..648372 1 NC_001148.3 Tip41p; Protein that interacts physically and genetically with Tap42p, which regulates protein phosphatase 2A; component of the TOR (target of rapamycin) signaling pathway 648372 TIP41 856153 TIP41 Saccharomyces cerevisiae Protein that interacts physically and genetically with Tap42p, which regulates protein phosphatase 2A; component of the TOR (target of rapamycin) signaling pathway NP_015365.1 647302 D 4932 CDS NP_015366.1 6325298 856154 648701..649918 1 NC_001148.3 Translation initiation factor eIF-5; N-terminal domain functions as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP; C-terminal domain is the core of ribosomal preinitiation complex formation; Tif5p 649918 TIF5 856154 TIF5 Saccharomyces cerevisiae Tif5p NP_015366.1 648701 D 4932 CDS NP_015367.1 6325299 856155 complement(650432..653659) 1 NC_001148.3 Puf2p; Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins 653659 PUF2 856155 PUF2 Saccharomyces cerevisiae Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins NP_015367.1 650432 R 4932 CDS NP_015368.1 6325300 856156 join(654163..654164,654568..654844) 1 NC_001148.3 Rpl43ap; Protein component of the large (60S) ribosomal subunit, identical to Rpl43Bp and has similarity to rat L37a ribosomal protein; null mutation confers a dominant lethal phenotype 654844 RPL43A 856156 RPL43A Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, identical to Rpl43Bp and has similarity to rat L37a ribosomal protein; null mutation confers a dominant lethal phenotype NP_015368.1 654163 D 4932 CDS NP_015370.1 6325302 856158 complement(655137..656549) 1 NC_001148.3 Mni2p; Deletion mutant is synthetically lethal with MEN mutants 656549 MNI2 856158 MNI2 Saccharomyces cerevisiae Deletion mutant is synthetically lethal with MEN mutants NP_015370.1 655137 R 4932 CDS NP_015371.1 6325303 856159 656796..657341 1 NC_001148.3 Protein involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; Mcm16p 657341 MCM16 856159 MCM16 Saccharomyces cerevisiae Mcm16p NP_015371.1 656796 D 4932 CDS NP_015372.2 37362703 856160 657526..658935 1 NC_001148.3 Msf1p; Mitochondrial phenylalanyl-tRNA synthetase alpha subunit, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase 658935 MSF1 856160 MSF1 Saccharomyces cerevisiae Mitochondrial phenylalanyl-tRNA synthetase alpha subunit, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase NP_015372.2 657526 D 4932 CDS NP_015373.1 6325305 856161 659179..661050 1 NC_001148.3 Tah18p; Protein with a potential role in DNA replication; displays synthetic lethal genetic interaction with the pol3-13 allele of POL3, which encodes DNA polymerase delta 661050 TAH18 856161 TAH18 Saccharomyces cerevisiae Protein with a potential role in DNA replication; displays synthetic lethal genetic interaction with the pol3-13 allele of POL3, which encodes DNA polymerase delta NP_015373.1 659179 D 4932 CDS NP_015374.1 6325306 856162 complement(661134..664670) 1 NC_001148.3 Peripheral membrane protein required for delivery of aminopeptidase I (Lap4p) to the vacuole in the cytoplasm-to-vacuole targeting pathway; also required for peroxisomal degradation (pexophagy); Atg11p 664670 ATG11 856162 ATG11 Saccharomyces cerevisiae Atg11p NP_015374.1 661134 R 4932 CDS NP_015376.1 6325307 856163 664957..665487 1 NC_001148.3 Mak3p; Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus 665487 MAK3 856163 MAK3 Saccharomyces cerevisiae Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus NP_015376.1 664957 D 4932 CDS NP_015377.1 6325309 856165 complement(665690..665971) 1 NC_001148.3 Nhp6ap; High-mobility group non-histone chromatin protein, functionally redundant with Nhp6Bp; homologous to mammalian high mobility group proteins 1 and 2; acts to recruit transcription factor Rcs1p to certain promoters 665971 NHP6A 856165 NHP6A Saccharomyces cerevisiae High-mobility group non-histone chromatin protein, functionally redundant with Nhp6Bp; homologous to mammalian high mobility group proteins 1 and 2; acts to recruit transcription factor Rcs1p to certain promoters NP_015377.1 665690 R 4932 CDS NP_015379.1 6325311 856167 666277..667443 1 NC_001148.3 Smk1p; Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p 667443 SMK1 856167 SMK1 Saccharomyces cerevisiae Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p NP_015379.1 666277 D 4932 CDS NP_015380.1 6325312 856168 667673..670870 1 NC_001148.3 Sec8p; Essential 121kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis 670870 SEC8 856168 SEC8 Saccharomyces cerevisiae Essential 121kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis NP_015380.1 667673 D 4932 CDS NP_015381.1 6325313 856169 671123..672139 1 NC_001148.3 Tfb4p; Subunit of TFIIH complex, involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p 672139 TFB4 856169 TFB4 Saccharomyces cerevisiae Subunit of TFIIH complex, involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p NP_015381.1 671123 D 4932 CDS NP_015382.1 6325314 856170 672468..673493 1 NC_001148.3 snRNP protein component of spliceosomal snRNPs, required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed; Brr1p 673493 BRR1 856170 BRR1 Saccharomyces cerevisiae Brr1p NP_015382.1 672468 D 4932 CDS NP_015383.1 6325315 856171 673748..674671 1 NC_001148.3 Ymc1p; Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc2p 674671 YMC1 856171 YMC1 Saccharomyces cerevisiae Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc2p NP_015383.1 673748 D 4932 CDS NP_015385.1 6325317 856173 complement(674858..675628) 1 NC_001148.3 Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis; Aro7p 675628 ARO7 856173 ARO7 Saccharomyces cerevisiae Aro7p NP_015385.1 674858 R 4932 CDS NP_015386.1 6325318 856174 complement(675974..676879) 1 NC_001148.3 Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae; Jid1p 676879 JID1 856174 JID1 Saccharomyces cerevisiae Jid1p NP_015386.1 675974 R 4932 CDS NP_015387.1 6325319 856175 677162..677638 1 NC_001148.3 Fcy1p; Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU) 677638 FCY1 856175 FCY1 Saccharomyces cerevisiae Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU) NP_015387.1 677162 D 4932 CDS NP_015388.1 6325320 856176 complement(join(677809..678190,678277..678317)) 1 NC_001148.3 Ypr063cp; ER-localized protein of unknown function 678317 856176 YPR063C Saccharomyces cerevisiae ER-localized protein of unknown function NP_015388.1 677809 R 4932 CDS NP_015390.1 6325322 856178 679690..680796 1 NC_001148.3 Rox1p; Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity 680796 ROX1 856178 ROX1 Saccharomyces cerevisiae Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity NP_015390.1 679690 D 4932 CDS NP_015391.1 6325323 856179 681210..682109 1 NC_001148.3 Uba3p; Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern 682109 UBA3 856179 UBA3 Saccharomyces cerevisiae Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern NP_015391.1 681210 D 4932 CDS NP_015392.1 6325324 856180 682217..682774 1 NC_001148.3 Protein required for maturation of mitochondrial and cytosolic Fe/S proteins, localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations; Isa2p 682774 ISA2 856180 ISA2 Saccharomyces cerevisiae Isa2p NP_015392.1 682217 D 4932 CDS NP_015393.1 6325325 856181 complement(682938..684350) 1 NC_001148.3 Putative class I histone deacetylase (HDAC) with sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; deletion results in increased histone acetylation at rDNA repeats; interacts with the Tup1p-Ssn6p corepressor complex; Hos1p 684350 HOS1 856181 HOS1 Saccharomyces cerevisiae Hos1p NP_015393.1 682938 R 4932 CDS NP_015394.1 6325326 856182 complement(684553..685434) 1 NC_001148.3 Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells; Spe3p 685434 SPE3 856182 SPE3 Saccharomyces cerevisiae Spe3p NP_015394.1 684553 R 4932 CDS NP_015395.1 6325327 856183 685895..687595 1 NC_001148.3 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; Med1p 687595 MED1 856183 MED1 Saccharomyces cerevisiae Med1p NP_015395.1 685895 D 4932 CDS NP_015396.1 6325328 856184 688169..688804 1 NC_001148.3 Ypr071wp; Putative membrane protein; YPR071W is not an essential gene 688804 856184 YPR071W Saccharomyces cerevisiae Putative membrane protein; YPR071W is not an essential gene NP_015396.1 688169 D 4932 CDS NP_015397.1 6325329 856186 690104..691786 1 NC_001148.3 Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation; Not5p 691786 NOT5 856186 NOT5 Saccharomyces cerevisiae Not5p NP_015397.1 690104 D 4932 CDS NP_015398.1 6325330 856187 complement(691930..692415) 1 NC_001148.3 Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine; Ltp1p 692415 LTP1 856187 LTP1 Saccharomyces cerevisiae Ltp1p NP_015398.1 691930 R 4932 CDS NP_015399.1 6325331 856188 complement(692793..694835) 1 NC_001148.3 Transketolase, similar to Tkl2p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; Tkl1p 694835 TKL1 856188 TKL1 Saccharomyces cerevisiae Tkl1p NP_015399.1 692793 R 4932 CDS NP_015400.1 6325333 856191 complement(695734..696816) 1 NC_001148.3 Opy2p; Integral membrane protein that functions in the signaling branch of the high-osmolarity glycerol (HOG) pathway; interacts with Ste50p; overproduction blocks cell cycle arrest in the presence of mating pheromone 696816 OPY2 856191 OPY2 Saccharomyces cerevisiae Integral membrane protein that functions in the signaling branch of the high-osmolarity glycerol (HOG) pathway; interacts with Ste50p; overproduction blocks cell cycle arrest in the presence of mating pheromone NP_015400.1 695734 R 4932 CDS NP_015403.1 6325335 856193 complement(697144..698262) 1 NC_001148.3 Ypr078cp; Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible 698262 856193 YPR078C Saccharomyces cerevisiae Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible NP_015403.1 697144 R 4932 CDS NP_015404.1 6325336 856194 698867..700012 1 NC_001148.3 Mrl1p; Membrane protein with similarity to mammalian mannose-6-phosphate receptors, possibly functions as a sorting receptor in the delivery of vacuolar hydrolases 700012 MRL1 856194 MRL1 Saccharomyces cerevisiae Membrane protein with similarity to mammalian mannose-6-phosphate receptors, possibly functions as a sorting receptor in the delivery of vacuolar hydrolases NP_015404.1 698867 D 4932 CDS NP_015405.1 6325337 856195 700592..701968 1 NC_001148.3 Translational elongation factor EF-1 alpha; also encoded by TEF2; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; Tef1p 701968 TEF1 856195 TEF1 Saccharomyces cerevisiae Tef1p NP_015405.1 700592 D 4932 CDS NP_015406.1 6325338 856196 complement(702112..703968) 1 NC_001148.3 Protein with sequence similarity to Grs1p, which is a glycyl-tRNA synthetase; cannot substitute for Grs1p; possible pseudogene that is expressed at very low levels; Grs2p 703968 GRS2 856196 GRS2 Saccharomyces cerevisiae Grs2p NP_015406.1 702112 R 4932 CDS NP_015407.1 6325339 856197 complement(704223..704654) 1 NC_001148.3 Dib1p; 17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein 704654 DIB1 856197 DIB1 Saccharomyces cerevisiae 17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein NP_015407.1 704223 R 4932 CDS NP_015408.1 6325340 856198 704852..706591 1 NC_001148.3 Protein required for normal mitochondrial morphology and inheritance; Mdm36p 706591 MDM36 856198 MDM36 Saccharomyces cerevisiae Mdm36p NP_015408.1 704852 D 4932 CDS NP_015409.1 6325341 856199 706970..708340 1 NC_001148.3 Ypr084wp; Putative protein of unknown function 708340 856199 YPR084W Saccharomyces cerevisiae Putative protein of unknown function NP_015409.1 706970 D 4932 CDS NP_015410.2 37362704 856200 complement(708495..709826) 1 NC_001148.3 Ypr085cp; Putative protein of unknown function; YPR085C is an essential gene 709826 856200 YPR085C Saccharomyces cerevisiae Putative protein of unknown function; YPR085C is an essential gene NP_015410.2 708495 R 4932 CDS NP_015411.1 6325343 856201 710099..711136 1 NC_001148.3 Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II; Sua7p 711136 SUA7 856201 SUA7 Saccharomyces cerevisiae Sua7p NP_015411.1 710099 D 4932 CDS NP_015413.1 6325345 856203 complement(711401..713026) 1 NC_001148.3 Srp54p; Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain 713026 SRP54 856203 SRP54 Saccharomyces cerevisiae Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain NP_015413.1 711401 R 4932 CDS NP_015414.2 37362705 856204 713273..715939 1 NC_001148.3 Ypr089wp; Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p 715939 856204 YPR089W Saccharomyces cerevisiae Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p NP_015414.2 713273 D 4932 CDS NP_015416.1 6325349 856207 complement(716154..718466) 1 NC_001148.3 Ypr091cp; Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YPR091C is not an essential gene 718466 856207 YPR091C Saccharomyces cerevisiae Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YPR091C is not an essential gene NP_015416.1 716154 R 4932 CDS NP_015418.2 37362706 856208 complement(719556..720422) 1 NC_001148.3 Protein involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain; Asr1p 720422 ASR1 856208 ASR1 Saccharomyces cerevisiae Asr1p NP_015418.2 719556 R 4932 CDS NP_015419.1 6325351 856209 720635..720958 1 NC_001148.3 Zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance; Rds3p 720958 RDS3 856209 RDS3 Saccharomyces cerevisiae Rds3p NP_015419.1 720635 D 4932 CDS NP_015420.1 6325352 856210 complement(721035..724715) 1 NC_001148.3 Syt1p; Guanine nucleotide exchange factor (GEF) for Arf proteins; involved in vesicular transport; suppressor of ypt3 mutations; member of the Sec7-domain family 724715 SYT1 856210 SYT1 Saccharomyces cerevisiae Guanine nucleotide exchange factor (GEF) for Arf proteins; involved in vesicular transport; suppressor of ypt3 mutations; member of the Sec7-domain family NP_015420.1 721035 R 4932 CDS NP_015421.1 6325353 856211 complement(724840..725142) 1 NC_001148.3 Ypr096cp; Protein of unknown function that may interact with ribosomes, based on co-purification experiments 725142 856211 YPR096C Saccharomyces cerevisiae Protein of unknown function that may interact with ribosomes, based on co-purification experiments NP_015421.1 724840 R 4932 CDS NP_015422.1 6325354 856212 725392..728613 1 NC_001148.3 Ypr097wp; Protein that contains a Phox homology (PX) domain and binds phosphoinositides; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies 728613 856212 YPR097W Saccharomyces cerevisiae Protein that contains a Phox homology (PX) domain and binds phosphoinositides; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies NP_015422.1 725392 D 4932 CDS NP_015423.2 37362707 856213 complement(join(728945..729383,729480..729526)) 1 NC_001148.3 Ypr098cp; Protein of unknown function, localized to the mitochondrial outer membrane 729526 856213 YPR098C Saccharomyces cerevisiae Protein of unknown function, localized to the mitochondrial outer membrane NP_015423.2 728945 R 4932 CDS NP_015425.1 6325356 856214 729789..730211 1 NC_001148.3 Mrpl51p; Mitochondrial ribosomal protein of the large subunit 730211 MRPL51 856214 MRPL51 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the large subunit NP_015425.1 729789 D 4932 CDS NP_015426.1 6325358 856216 730490..731017 1 NC_001148.3 Snt309p; Component of NineTeen complex (NTC) containing Prp19p involved in mRNA splicing, interacts physically and genetically with Prp19p 731017 SNT309 856216 SNT309 Saccharomyces cerevisiae Component of NineTeen complex (NTC) containing Prp19p involved in mRNA splicing, interacts physically and genetically with Prp19p NP_015426.1 730490 D 4932 CDS NP_015427.1 6325359 856217 complement(731222..731746) 1 NC_001148.3 Rpl11ap; Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Bp; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11 731746 RPL11A 856217 RPL11A Saccharomyces cerevisiae Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Bp; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11 NP_015427.1 731222 R 4932 CDS NP_015428.1 6325360 856218 732347..733210 1 NC_001148.3 Pre2p; 20S proteasome beta-type subunit, responsible for the chymotryptic activity of the proteasome 733210 PRE2 856218 PRE2 Saccharomyces cerevisiae 20S proteasome beta-type subunit, responsible for the chymotryptic activity of the proteasome NP_015428.1 732347 D 4932 CDS NP_015429.1 6325361 856219 complement(733621..736431) 1 NC_001148.3 Transcriptional activator with similarity to DNA-binding domain of Drosophila forkhead but unable to bind DNA in vitro; required for rRNA processing; isolated as a suppressor of splicing factor prp4; Fhl1p 736431 FHL1 856219 FHL1 Saccharomyces cerevisiae Fhl1p NP_015429.1 733621 R 4932 CDS NP_015430.1 6325362 856220 complement(736982..739567) 1 NC_001148.3 Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; Cog4p 739567 COG4 856220 COG4 Saccharomyces cerevisiae Cog4p NP_015430.1 736982 R 4932 CDS NP_015431.1 6325363 856221 740059..741390 1 NC_001148.3 Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C; Isr1p 741390 ISR1 856221 ISR1 Saccharomyces cerevisiae Isr1p NP_015431.1 740059 D 4932 CDS NP_015432.1 6325364 856222 complement(741436..742062) 1 NC_001148.3 Yth1p; Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation 742062 YTH1 856222 YTH1 Saccharomyces cerevisiae Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation NP_015432.1 741436 R 4932 CDS NP_015433.1 6325365 856223 742452..743741 1 NC_001148.3 Rpn7p; Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits 743741 RPN7 856223 RPN7 Saccharomyces cerevisiae Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits NP_015433.1 742452 D 4932 CDS NP_878183.1 33438895 1466522 744173..744385 1 NC_001148.3 Ypr108w-ap; Putative protein of unknown function; identified by fungal homology and RT-PCR 744385 1466522 YPR108W-A Saccharomyces cerevisiae Putative protein of unknown function; identified by fungal homology and RT-PCR NP_878183.1 744173 D 4932 CDS NP_015434.1 6325366 856225 744687..745571 1 NC_001148.3 Ypr109wp; Predicted membrane protein; dipoid deletion strain has high budding index 745571 856225 YPR109W Saccharomyces cerevisiae Predicted membrane protein; dipoid deletion strain has high budding index NP_015434.1 744687 D 4932 CDS NP_015435.1 6325367 856226 complement(745826..746833) 1 NC_001148.3 Rpc40p; RNA polymerase subunit, common to RNA polymerase I and III 746833 RPC40 856226 RPC40 Saccharomyces cerevisiae RNA polymerase subunit, common to RNA polymerase I and III NP_015435.1 745826 R 4932 CDS NP_015436.1 6325368 856227 747304..748998 1 NC_001148.3 Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; Dbf20p 748998 DBF20 856227 DBF20 Saccharomyces cerevisiae Dbf20p NP_015436.1 747304 D 4932 CDS NP_015437.1 6325369 856228 complement(749254..751917) 1 NC_001148.3 Mrd1p; Essential conserved protein that associates with 35S precursor rRNA and is required for its initial processing at the A(0)-A(2) cleavage sites, shows partial nucleolar localization, contains five consensus RNA-binding domains 751917 MRD1 856228 MRD1 Saccharomyces cerevisiae Essential conserved protein that associates with 35S precursor rRNA and is required for its initial processing at the A(0)-A(2) cleavage sites, shows partial nucleolar localization, contains five consensus RNA-binding domains NP_015437.1 749254 R 4932 CDS NP_015438.1 6325370 856229 752255..752917 1 NC_001148.3 Pis1p; Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins 752917 PIS1 856229 PIS1 Saccharomyces cerevisiae Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins NP_015438.1 752255 D 4932 CDS NP_015439.1 6325371 856230 753299..754246 1 NC_001148.3 Ypr114wp; Putative protein of unknown function 754246 856230 YPR114W Saccharomyces cerevisiae Putative protein of unknown function NP_015439.1 753299 D 4932 CDS NP_015440.1 6325372 856231 754875..758126 1 NC_001148.3 Ypr115wp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm 758126 856231 YPR115W Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm NP_015440.1 754875 D 4932 CDS NP_015441.1 6325373 856232 758646..759479 1 NC_001148.3 Ypr116wp; Putative protein of unknown function 759479 856232 YPR116W Saccharomyces cerevisiae Putative protein of unknown function NP_015441.1 758646 D 4932 CDS NP_015442.1 6325374 856233 760023..767492 1 NC_001148.3 Ypr117wp; Putative protein of unknown function 767492 856233 YPR117W Saccharomyces cerevisiae Putative protein of unknown function NP_015442.1 760023 D 4932 CDS NP_015443.1 6325375 856234 767750..768985 1 NC_001148.3 Mri1p; Methylthioribose-1-phosphate isomerase, catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway 768985 MRI1 856234 MRI1 Saccharomyces cerevisiae Methylthioribose-1-phosphate isomerase, catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway NP_015443.1 767750 D 4932 CDS NP_015444.1 6325376 856236 771651..773126 1 NC_001148.3 Clb2p; B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome 773126 CLB2 856236 CLB2 Saccharomyces cerevisiae B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome NP_015444.1 771651 D 4932 CDS NP_015445.1 6325377 856237 complement(773873..775180) 1 NC_001148.3 Clb5p; B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase 775180 CLB5 856237 CLB5 Saccharomyces cerevisiae B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase NP_015445.1 773873 R 4932 CDS NP_015446.1 6325378 856239 778579..780297 1 NC_001148.3 Thi22p; Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis 780297 THI22 856239 THI22 Saccharomyces cerevisiae Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis NP_015446.1 778579 D 4932 CDS NP_015447.1 6325379 856240 782041..785667 1 NC_001148.3 Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells; Axl1p 785667 AXL1 856240 AXL1 Saccharomyces cerevisiae Axl1p NP_015447.1 782041 D 4932 CDS NP_015449.1 6325380 856241 786204..787424 1 NC_001148.3 High-affinity copper transporter of the plasma membrane, mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; Ctr1p 787424 CTR1 856241 CTR1 Saccharomyces cerevisiae Ctr1p NP_015449.1 786204 D 4932 CDS NP_015450.1 6325382 856243 787957..789321 1 NC_001148.3 Ylh47p; Mitochondrial inner membrane protein exposed to the mitochondrial matrix, associates with mitochondrial ribosomes, NOT required for respiratory growth; homolog of human Letm1, a protein implicated in Wolf-Hirschhorn syndrome 789321 YLH47 856243 YLH47 Saccharomyces cerevisiae Mitochondrial inner membrane protein exposed to the mitochondrial matrix, associates with mitochondrial ribosomes, NOT required for respiratory growth; homolog of human Letm1, a protein implicated in Wolf-Hirschhorn syndrome NP_015450.1 787957 D 4932 CDS NP_015452.1 6325384 856245 790079..791116 1 NC_001148.3 Ypr127wp; Putative protein of unknown function; expression is activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus 791116 856245 YPR127W Saccharomyces cerevisiae Putative protein of unknown function; expression is activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus NP_015452.1 790079 D 4932 CDS NP_015453.1 6325385 856246 complement(791214..792200) 1 NC_001148.3 Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation; Ant1p 792200 ANT1 856246 ANT1 Saccharomyces cerevisiae Ant1p NP_015453.1 791214 R 4932 CDS NP_015454.1 6325386 856247 792683..793732 1 NC_001148.3 Scd6p; Protein containing an Lsm domain, may bind RNA and have a role in RNA processing; overproduction suppresses a null mutation in CHC1, which encodes the heavy chain of clathrin 793732 SCD6 856247 SCD6 Saccharomyces cerevisiae Protein containing an Lsm domain, may bind RNA and have a role in RNA processing; overproduction suppresses a null mutation in CHC1, which encodes the heavy chain of clathrin NP_015454.1 792683 D 4932 CDS NP_015456.2 31126970 856249 complement(793907..794494) 1 NC_001148.3 Nat3p; Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met 794494 NAT3 856249 NAT3 Saccharomyces cerevisiae Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met NP_015456.2 793907 R 4932 CDS NP_015457.1 6325389 856250 join(794961..795025,795391..795763) 1 NC_001148.3 Rps23bp; Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; nearly identical to Rps23Ap and similar to E. coli S12 and rat S23 ribosomal proteins; deletion of both RPS23A and RPS23B is lethal 795763 RPS23B 856250 RPS23B Saccharomyces cerevisiae Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; nearly identical to Rps23Ap and similar to E. coli S12 and rat S23 ribosomal proteins; deletion of both RPS23A and RPS23B is lethal NP_015457.1 794961 D 4932 CDS NP_015458.1 6325390 856251 complement(795974..797206) 1 NC_001148.3 Spn1p; Protein that interacts with Spt6p and copurifies with Spt5p and RNA polymerase II, probable transcriptional elongation factor; metazoan homologs contain an acidic N terminus; mutations in the gene confer an Spt- phenotype 797206 SPN1 856251 SPN1 Saccharomyces cerevisiae Protein that interacts with Spt6p and copurifies with Spt5p and RNA polymerase II, probable transcriptional elongation factor; metazoan homologs contain an acidic N terminus; mutations in the gene confer an Spt- phenotype NP_015458.1 795974 R 4932 CDS NP_015459.1 6325391 856252 797553..797705 1 NC_001148.3 Tom5p; Small mitochondrial outer membrane protein crucial to a binding relay for the import of proteins into mitochondria; subunit on the outer mouth of the TOM channel that accepts precursors from the receptors Tom20p and Tom22p 797705 TOM5 856252 TOM5 Saccharomyces cerevisiae Small mitochondrial outer membrane protein crucial to a binding relay for the import of proteins into mitochondria; subunit on the outer mouth of the TOM channel that accepts precursors from the receptors Tom20p and Tom22p NP_015459.1 797553 D 4932 CDS NP_015460.1 6325392 856253 798047..798853 1 NC_001148.3 Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions; Mss18p 798853 MSS18 856253 MSS18 Saccharomyces cerevisiae Mss18p NP_015460.1 798047 D 4932 CDS NP_015461.1 6325393 856254 799230..802013 1 NC_001148.3 Ctf4p; Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion 802013 CTF4 856254 CTF4 Saccharomyces cerevisiae Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion NP_015461.1 799230 D 4932 CDS NP_015463.1 6325394 856255 802355..804076 1 NC_001148.3 Rrp9p; Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein 804076 RRP9 856255 RRP9 Saccharomyces cerevisiae Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein NP_015463.1 802355 D 4932 CDS NP_058191.1 7839207 856257 complement(join(804997..808959,808961..810265)) 1 NC_001148.3 Ypr137c-bp; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 810265 856257 YPR137C-B Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_058191.1 804997 R 4932 CDS NP_058192.1 7839206 856258 complement(808943..810265) 1 NC_001148.3 Ypr137c-ap; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 810265 856258 YPR137C-A Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_058192.1 808943 R 4932 CDS NP_015464.1 6325396 856260 complement(810980..812449) 1 NC_001148.3 Mep3p; Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease 812449 MEP3 856260 MEP3 Saccharomyces cerevisiae Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease NP_015464.1 810980 R 4932 CDS NP_015465.1 6325397 856261 complement(813152..814054) 1 NC_001148.3 Vps66p; Cytoplasmic protein of unknown function involved in vacuolar protein sorting. 814054 VPS66 856261 VPS66 Saccharomyces cerevisiae Cytoplasmic protein of unknown function involved in vacuolar protein sorting. NP_015465.1 813152 R 4932 CDS NP_015466.1 6325398 856262 814387..815532 1 NC_001148.3 Taz1p; Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; similar to human tafazzin, which is implicated in Barth syndrome 815532 TAZ1 856262 TAZ1 Saccharomyces cerevisiae Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; similar to human tafazzin, which is implicated in Barth syndrome NP_015466.1 814387 D 4932 CDS NP_015467.1 6325399 856263 complement(815730..817919) 1 NC_001148.3 Minus-end-directed microtubule motor that functions in mitosis and meiosis, localizes to the spindle pole body and localization is dependent on functional Cik1p, required for nuclear fusion during mating; potential Cdc28p substrate; Kar3p 817919 KAR3 856263 KAR3 Saccharomyces cerevisiae Kar3p NP_015467.1 815730 R 4932 CDS NP_015469.1 6325400 856264 818319..819071 1 NC_001148.3 Rrp15p; Nucleolar protein, constituent of pre-60S ribosomal particles; required for processing of the 27S pre-rRNA at the A2 site to yield 5.8S and 25S rRNA 819071 RRP15 856264 RRP15 Saccharomyces cerevisiae Nucleolar protein, constituent of pre-60S ribosomal particles; required for processing of the 27S pre-rRNA at the A2 site to yield 5.8S and 25S rRNA NP_015469.1 818319 D 4932 CDS NP_015470.1 6325402 856267 complement(819761..821419) 1 NC_001148.3 Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits; Noc4p 821419 NOC4 856267 NOC4 Saccharomyces cerevisiae Noc4p NP_015470.1 819761 R 4932 CDS NP_015471.1 6325403 856268 822616..824334 1 NC_001148.3 Asparagine synthetase, isozyme of Asn2p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; Asn1p 824334 ASN1 856268 ASN1 Saccharomyces cerevisiae Asn1p NP_015471.1 822616 D 4932 CDS NP_001032572.1 82795262 3799978 complement(824686..824922) 1 NC_001148.3 Ypr145c-ap; Putative protein of unknown function 824922 3799978 YPR145C-A Saccharomyces cerevisiae Putative protein of unknown function NP_001032572.1 824686 R 4932 CDS NP_015473.1 6325405 856270 complement(825641..826555) 1 NC_001148.3 Ypr147cp; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS 826555 856270 YPR147C Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS NP_015473.1 825641 R 4932 CDS NP_015474.1 6325406 856271 complement(826829..828136) 1 NC_001148.3 Ypr148cp; Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern 828136 856271 YPR148C Saccharomyces cerevisiae Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern NP_015474.1 826829 R 4932 CDS NP_015475.1 6325407 856272 829914..830435 1 NC_001148.3 Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs); Nce102p 830435 NCE102 856272 NCE102 Saccharomyces cerevisiae Nce102p NP_015475.1 829914 D 4932 CDS NP_015477.1 6325409 856274 complement(831051..831671) 1 NC_001148.3 Sue1p; Mitochondrial protein required for degradation of unstable forms of cytochrome c 831671 SUE1 856274 SUE1 Saccharomyces cerevisiae Mitochondrial protein required for degradation of unstable forms of cytochrome c NP_015477.1 831051 R 4932 CDS NP_015478.1 6325410 856275 complement(832057..833454) 1 NC_001148.3 Urn1p; Pre-mRNA splicing factor associated with the U2-U5-U6 snRNPs, the RES complex, and the Prp19-associated complex (NTC); null mutation displays synthetic genetic interactions with mutations affecting U2 snRNA and pre-mRNA splicing factors 833454 URN1 856275 URN1 Saccharomyces cerevisiae Pre-mRNA splicing factor associated with the U2-U5-U6 snRNPs, the RES complex, and the Prp19-associated complex (NTC); null mutation displays synthetic genetic interactions with mutations affecting U2 snRNA and pre-mRNA splicing factors NP_015478.1 832057 R 4932 CDS NP_015479.2 154200012 856276 join(833685..833689,833824..834241) 1 NC_001148.3 Ypr153wp; Putative protein of unknown function 834241 856276 YPR153W Saccharomyces cerevisiae Putative protein of unknown function NP_015479.2 833685 D 4932 CDS NP_015480.1 6325412 856277 834561..835208 1 NC_001148.3 Protein that induces appearance of [PIN+] prion when overproduced; Pin3p 835208 PIN3 856277 PIN3 Saccharomyces cerevisiae Pin3p NP_015480.1 834561 D 4932 CDS NP_015481.1 6325413 856278 complement(835559..837409) 1 NC_001148.3 Protein involved in regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; functions with Nca3p; Nca2p 837409 NCA2 856278 NCA2 Saccharomyces cerevisiae Nca2p NP_015481.1 835559 R 4932 CDS NP_015482.1 6325414 856279 complement(837905..839773) 1 NC_001148.3 Tpo3p; Polyamine transport protein specific for spermine; localizes to the plasma membrane; member of the major facilitator superfamily 839773 TPO3 856279 TPO3 Saccharomyces cerevisiae Polyamine transport protein specific for spermine; localizes to the plasma membrane; member of the major facilitator superfamily NP_015482.1 837905 R 4932 CDS NP_015483.1 6325415 856280 841262..842665 1 NC_001148.3 Ypr157wp; Putative protein of unknown function 842665 856280 YPR157W Saccharomyces cerevisiae Putative protein of unknown function NP_015483.1 841262 D 4932 CDS NP_015484.1 6325416 856281 843258..844016 1 NC_001148.3 Ypr158wp; Putative protein of unknown function 844016 856281 YPR158W Saccharomyces cerevisiae Putative protein of unknown function NP_015484.1 843258 D 4932 CDS NP_058193.1 7839209 856283 join(844705..846009,846011..849976) 1 NC_001148.3 Ypr158w-bp; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 849976 856283 YPR158W-B Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_058193.1 844705 D 4932 CDS NP_058194.1 7839208 856282 844705..846027 1 NC_001148.3 Ypr158w-ap; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 846027 856282 YPR158W-A Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_058194.1 844705 D 4932 CDS NP_058195.1 7839211 856284 complement(join(850985..854947,854949..856253)) 1 NC_001148.3 Ypr158c-dp; Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes 856253 856284 YPR158C-D Saccharomyces cerevisiae Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes NP_058195.1 850985 R 4932 CDS NP_058196.1 7839210 856285 complement(854931..856253) 1 NC_001148.3 Ypr158c-cp; Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag 856253 856285 YPR158C-C Saccharomyces cerevisiae Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag NP_058196.1 854931 R 4932 CDS NP_015485.1 6325417 856287 857579..859741 1 NC_001148.3 Protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; appears functionally redundant with Skn1p; Kre6p 859741 KRE6 856287 KRE6 Saccharomyces cerevisiae Kre6p NP_015485.1 857579 D 4932 CDS NP_878184.1 33438896 1466523 complement(860310..860411) 1 NC_001148.3 Ypr159c-ap; Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching 860411 1466523 YPR159C-A Saccharomyces cerevisiae Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching NP_878184.1 860310 R 4932 CDS NP_015486.1 6325418 856289 861302..864010 1 NC_001148.3 Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway; Gph1p 864010 GPH1 856289 GPH1 Saccharomyces cerevisiae Gph1p NP_015486.1 861302 D 4932 CDS NP_015487.1 6325419 856290 complement(864445..866418) 1 NC_001148.3 Sgv1p; Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation; phosphorylates the carboxy-terminal domain of Rpo21p, which is the largest subunit of RNA polymerase II; regulated by Cak1p 866418 SGV1 856290 SGV1 Saccharomyces cerevisiae Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation; phosphorylates the carboxy-terminal domain of Rpo21p, which is the largest subunit of RNA polymerase II; regulated by Cak1p NP_015487.1 864445 R 4932 CDS NP_015488.1 6325420 856291 complement(866711..868300) 1 NC_001148.3 Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; Orc4p 868300 ORC4 856291 ORC4 Saccharomyces cerevisiae Orc4p NP_015488.1 866711 R 4932 CDS NP_015489.1 6325421 856292 complement(868641..869951) 1 NC_001148.3 Translation initiation factor eIF-4B, has RNA annealing activity; contains an RNA recognition motif and binds to single-stranded RNA; Tif3p 869951 TIF3 856292 TIF3 Saccharomyces cerevisiae Tif3p NP_015489.1 868641 R 4932 CDS NP_015490.1 6325422 856293 870699..874922 1 NC_001148.3 Protein likely involved in protection against replication-dependent DNA damage; mutants are sensitive to methyl methanesulfonate (MMS); implicated in regulation of Ty1 transposition; Mms1p 874922 MMS1 856293 MMS1 Saccharomyces cerevisiae Mms1p NP_015490.1 870699 D 4932 CDS NP_015491.1 6325423 856294 875364..875993 1 NC_001148.3 Rho1p; GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p) 875993 RHO1 856294 RHO1 Saccharomyces cerevisiae GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p) NP_015491.1 875364 D 4932 CDS NP_015492.1 6325424 856295 complement(876278..876625) 1 NC_001148.3 Mrp2p; Mitochondrial ribosomal protein of the small subunit 876625 MRP2 856295 MRP2 Saccharomyces cerevisiae Mitochondrial ribosomal protein of the small subunit NP_015492.1 876278 R 4932 CDS NP_015493.1 6325425 856296 complement(876843..877628) 1 NC_001148.3 Met16p; 3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism 877628 MET16 856296 MET16 Saccharomyces cerevisiae 3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism NP_015493.1 876843 R 4932 CDS NP_015494.1 6325426 856297 878072..878545 1 NC_001148.3 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription; Nut2p 878545 NUT2 856297 NUT2 Saccharomyces cerevisiae Nut2p NP_015494.1 878072 D 4932 CDS NP_015495.2 83578109 856298 878686..880164 1 NC_001148.3 Nucleolar protein of unknown function, exhibits a physical interaction with Bre1p; Jip5p 880164 JIP5 856298 JIP5 Saccharomyces cerevisiae Jip5p NP_015495.2 878686 D 4932 CDS NP_001106949.1 165940969 5848745 join(883235..883383,883483..883591) 1 NC_001148.3 Ypr170w-bp; Putative protein of unknown function, conserved in fungi; partially overlaps the dubious genes YPR169W-A, YPR170W-A and YRP170C 883591 5848745 YPR170W-B Saccharomyces cerevisiae Putative protein of unknown function, conserved in fungi; partially overlaps the dubious genes YPR169W-A, YPR170W-A and YRP170C NP_001106949.1 883235 D 4932 CDS NP_015497.1 6325429 856301 883824..885554 1 NC_001148.3 Bsp1p; Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton 885554 BSP1 856301 BSP1 Saccharomyces cerevisiae Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton NP_015497.1 883824 D 4932 CDS NP_015498.1 6325430 856302 885792..886394 1 NC_001148.3 Ypr172wp; Protein of unknown function, transcriptionally activated by Yrm1p along with genes involved in multidrug resistance 886394 856302 YPR172W Saccharomyces cerevisiae Protein of unknown function, transcriptionally activated by Yrm1p along with genes involved in multidrug resistance NP_015498.1 885792 D 4932 CDS NP_015499.1 6325431 856303 complement(886520..887833) 1 NC_001148.3 Vps4p; AAA-type ATPase that is regulated by Vta1p; required for late endosome to vacuole transport; catalyzes the release of an endosomal membrane-associated class E VPS protein complex; regulates cellular sterol metabolism 887833 VPS4 856303 VPS4 Saccharomyces cerevisiae AAA-type ATPase that is regulated by Vta1p; required for late endosome to vacuole transport; catalyzes the release of an endosomal membrane-associated class E VPS protein complex; regulates cellular sterol metabolism NP_015499.1 886520 R 4932 CDS NP_015500.1 6325432 856304 complement(888039..888704) 1 NC_001148.3 Ypr174cp; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate 888704 856304 YPR174C Saccharomyces cerevisiae Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate NP_015500.1 888039 R 4932 CDS NP_015501.2 37362708 856305 888970..891039 1 NC_001148.3 Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for normal yeast chromosomal replication; expression peaks at the G1/S phase boundary; potential Cdc28p substrate; Dpb2p 891039 DPB2 856305 DPB2 Saccharomyces cerevisiae Dpb2p NP_015501.2 888970 D 4932 CDS NP_015502.1 6325434 856306 complement(891097..892074) 1 NC_001148.3 Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p; Bet2p 892074 BET2 856306 BET2 Saccharomyces cerevisiae Bet2p NP_015502.1 891097 R 4932 CDS NP_015504.1 6325435 856307 892328..893725 1 NC_001148.3 Splicing factor, component of the U4/U6-U5 snRNP complex; Prp4p 893725 PRP4 856307 PRP4 Saccharomyces cerevisiae Prp4p NP_015504.1 892328 D 4932 CDS NP_015505.1 6325437 856309 complement(893793..895760) 1 NC_001148.3 Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex that contains an Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; has similarity to Hda2p; Hda3p 895760 HDA3 856309 HDA3 Saccharomyces cerevisiae Hda3p NP_015505.1 893793 R 4932 CDS NP_015506.1 6325438 856310 895957..897000 1 NC_001148.3 Nuclear protein that acts as a heterodimer with Uba2p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability; Aos1p 897000 AOS1 856310 AOS1 Saccharomyces cerevisiae Aos1p NP_015506.1 895957 D 4932 CDS NP_015507.1 6325439 856311 complement(897357..899663) 1 NC_001148.3 Sec23p; GTPase-activating protein; component of the Sec23p-Sec24p heterodimeric complex of the COPII vesicle coat, involved in ER to Golgi transport and autophagy; stimulates the GDP-bound form of Sar1p 899663 SEC23 856311 SEC23 Saccharomyces cerevisiae GTPase-activating protein; component of the Sec23p-Sec24p heterodimeric complex of the COPII vesicle coat, involved in ER to Golgi transport and autophagy; stimulates the GDP-bound form of Sar1p NP_015507.1 897357 R 4932 CDS NP_015508.1 6325440 856312 900190..900450 1 NC_001148.3 Smx3p; Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F 900450 SMX3 856312 SMX3 Saccharomyces cerevisiae Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F NP_015508.1 900190 D 4932 CDS NP_015509.1 6325441 856313 900751..901554 1 NC_001148.3 Dpm1p; Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation 901554 DPM1 856313 DPM1 Saccharomyces cerevisiae Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation NP_015509.1 900751 D 4932 CDS NP_015510.1 6325442 856314 902040..906650 1 NC_001148.3 Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria; Gdb1p 906650 GDB1 856314 GDB1 Saccharomyces cerevisiae Gdb1p NP_015510.1 902040 D 4932 CDS NP_015511.1 6325443 856315 907214..909430 1 NC_001148.3 Phosphorylated protein that interacts with Vac8p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway and autophagy; Atg13p 909430 ATG13 856315 ATG13 Saccharomyces cerevisiae Atg13p NP_015511.1 907214 D 4932 CDS NP_015512.1 6325444 856316 complement(909729..911018) 1 NC_001148.3 Transcription factor IIIA (TFIIIA), essential protein with nine C2H2 Zn-fingers, binds the 5S rRNA gene through the zinc finger domain and directs assembly of a multiprotein initiation complex for RNA polymerase III; also binds DNA; Pzf1p 911018 PZF1 856316 PZF1 Saccharomyces cerevisiae Pzf1p NP_015512.1 909729 R 4932 CDS NP_015513.1 6325445 856317 join(911253..911272,911349..911796) 1 NC_001148.3 Rpo26p; RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit 911796 RPO26 856317 RPO26 Saccharomyces cerevisiae RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit NP_015513.1 911253 D 4932 CDS NP_015514.1 6325446 856318 complement(911984..912475) 1 NC_001148.3 Regulatory light chain for the type II myosin, Myo1p; binds to an IQ motif of Myo1p, localization to the bud neck depends on Myo1p; involved in the disassembly of the Myo1p ring; Mlc2p 912475 MLC2 856318 MLC2 Saccharomyces cerevisiae Mlc2p NP_015514.1 911984 R 4932 CDS NP_015515.1 6325447 856319 912660..916958 1 NC_001148.3 Ski3p; Protein involved in exosome mediated 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs; forms complex with Ski2p and Ski8p; required for repressing propagation of dsRNA viruses 916958 SKI3 856319 SKI3 Saccharomyces cerevisiae Protein involved in exosome mediated 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs; forms complex with Ski2p and Ski8p; required for repressing propagation of dsRNA viruses NP_015515.1 912660 D 4932 CDS NP_015516.1 6325448 856320 complement(917073..919037) 1 NC_001148.3 Rpc82p; RNA polymerase III subunit C82 919037 RPC82 856320 RPC82 Saccharomyces cerevisiae RNA polymerase III subunit C82 NP_015516.1 917073 R 4932 CDS NP_015517.1 6325449 856321 919377..920483 1 NC_001148.3 Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme; Qcr2p 920483 QCR2 856321 QCR2 Saccharomyces cerevisiae Qcr2p NP_015517.1 919377 D 4932 CDS NP_015518.1 6325450 856322 921856..922773 1 NC_001148.3 Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance; Aqy1p 922773 AQY1 856322 AQY1 Saccharomyces cerevisiae Aqy1p NP_015518.1 921856 D 4932 CDS NP_015519.1 6325451 856323 complement(922905..923375) 1 NC_001148.3 Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity; Hpa2p 923375 HPA2 856323 HPA2 Saccharomyces cerevisiae Hpa2p NP_015519.1 922905 R 4932 CDS NP_015520.1 6325452 856324 complement(924300..926933) 1 NC_001148.3 Opt2p; Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans 926933 OPT2 856324 OPT2 Saccharomyces cerevisiae Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans NP_015520.1 924300 R 4932 CDS NP_015522.1 6325454 856326 931372..932784 1 NC_001148.3 Ypr196wp; Putative maltose activator 932784 856326 YPR196W Saccharomyces cerevisiae Putative maltose activator NP_015522.1 931372 D 4932 CDS NP_015524.1 6325455 856327 934030..935661 1 NC_001148.3 Sge1p; Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations 935661 SGE1 856327 SGE1 Saccharomyces cerevisiae Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations NP_015524.1 934030 D 4932 CDS NP_015525.1 6325457 856329 complement(938144..939028) 1 NC_001148.3 Transcriptional activator of the bZIP family, required for transcription of genes involved in resistance to arsenic compounds; Arr1p 939028 ARR1 856329 ARR1 Saccharomyces cerevisiae Arr1p NP_015525.1 938144 R 4932 CDS NP_015526.1 6325458 856330 complement(939275..939667) 1 NC_001148.3 Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p; Arr2p 939667 ARR2 856330 ARR2 Saccharomyces cerevisiae Arr2p NP_015526.1 939275 R 4932 CDS NP_015527.1 6325459 856331 939918..941132 1 NC_001148.3 Arsenite transporter of the plasma membrane, required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite; Arr3p 941132 ARR3 856331 ARR3 Saccharomyces cerevisiae Arr3p NP_015527.1 939918 D 4932 CDS NP_015528.1 6325460 856332 join(943028..943046,943195..943892) 1 NC_001148.3 Ypr202wp; Putative protein of unknown function with similarity to telomere-encoded helicases; YPR202W is not an essential gene; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo 943892 856332 YPR202W Saccharomyces cerevisiae Putative protein of unknown function with similarity to telomere-encoded helicases; YPR202W is not an essential gene; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo NP_015528.1 943028 D 4932 CDS NP_015529.1 6325461 856333 943876..944184 1 NC_001148.3 Ypr203wp; Putative protein of unknown function 944184 856333 YPR203W Saccharomyces cerevisiae Putative protein of unknown function NP_015529.1 943876 D 4932 CDS NP_015530.1 6325462 856334 944599..947697 1 NC_001148.3 Ypr204wp; Helicase-like protein encoded within the telomeric Y' element 947697 856334 YPR204W Saccharomyces cerevisiae Helicase-like protein encoded within the telomeric Y' element NP_015530.1 944599 D 4932 CDS