-- dump date 20140620_054942 -- class Genbank::misc_feature -- table misc_feature_note -- id note 588858000001 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 588858000002 putative phospholipase D; disrupted by frameshift 588858000003 replication protein; Provisional; Region: PRK13702 588858000004 RepA leader peptide Tap; Provisional; Region: PRK14745 588858000005 replication protein; Provisional; Region: PRK13750 588858000006 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 588858000007 SdiA-regulated; Region: SdiA-regulated; cd09971 588858000008 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 588858000009 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 588858000010 resistance to complement killing; Provisional; Region: PRK15240 588858000011 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 588858000012 SdiA-regulated; Region: SdiA-regulated; cd09971 588858000013 putative active site [active] 588858000014 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 588858000015 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 588858000016 catalytic residues [active] 588858000017 hinge region; other site 588858000018 alpha helical domain; other site 588858000019 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 588858000020 DNA binding residues [nucleotide binding] 588858000021 dimerization interface [polypeptide binding]; other site 588858000022 FaeA-like protein; Region: FaeA; pfam04703 588858000023 fimbrial chaperone protein PefD; Provisional; Region: PRK15211 588858000024 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 588858000025 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 588858000026 fimbrial outer membrane usher protein PefC; Provisional; Region: PRK15213 588858000027 PapC N-terminal domain; Region: PapC_N; pfam13954 588858000028 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 588858000029 fimbrial protein PefA; Provisional; Region: PRK15214 588858000030 Adhesin biosynthesis transcription regulatory protein; Region: PapB; pfam03333 588858000031 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 588858000032 plasmid maintenance protein CcdA; Provisional; Region: PRK13710 588858000033 plasmid maintenance protein CcdB; Provisional; Region: PRK13708 588858000034 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 588858000035 active site 588858000036 catalytic residues [active] 588858000037 DNA binding site [nucleotide binding] 588858000038 Int/Topo IB signature motif; other site 588858000039 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 588858000040 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 588858000041 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 588858000042 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 588858000043 Transposase IS200 like; Region: Y1_Tnp; pfam01797 588858000044 virulence protein SpvD; Provisional; Region: PRK15250 588858000045 Salmonella virulence-associated 28kDa protein; Region: VRP3; pfam03536 588858000046 virulence protein SpvB; Provisional; Region: PRK15244 588858000047 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 588858000048 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 588858000049 active site 588858000050 conformational flexibility of ligand binding pocket; other site 588858000051 ADP-ribosylating toxin turn-turn motif; other site 588858000052 virulence protein SpvA; Provisional; Region: PRK15212 588858000053 transcriptional regulator SpvR; Provisional; Region: PRK15243 588858000054 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858000055 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 588858000056 Homeodomain-like domain; Region: HTH_23; pfam13384 588858000057 Winged helix-turn helix; Region: HTH_29; pfam13551 588858000058 Homeodomain-like domain; Region: HTH_32; pfam13565 588858000059 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 588858000060 DDE superfamily endonuclease; Region: DDE_3; pfam13358 588858000061 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 588858000062 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 588858000063 Walker A/P-loop; other site 588858000064 Integrase core domain; Region: rve; pfam00665 588858000065 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 588858000066 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 588858000067 catalytic residues [active] 588858000068 catalytic nucleophile [active] 588858000069 Presynaptic Site I dimer interface [polypeptide binding]; other site 588858000070 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 588858000071 Synaptic Flat tetramer interface [polypeptide binding]; other site 588858000072 Synaptic Site I dimer interface [polypeptide binding]; other site 588858000073 DNA binding site [nucleotide binding] 588858000074 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 588858000075 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 588858000076 active site clefts [active] 588858000077 zinc binding site [ion binding]; other site 588858000078 dimer interface [polypeptide binding]; other site 588858000079 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 588858000080 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 588858000081 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 588858000082 catalytic site [active] 588858000083 Uncharacterized conserved protein [Function unknown]; Region: COG5464 588858000084 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 588858000085 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 588858000086 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 588858000087 P-loop; other site 588858000088 Magnesium ion binding site [ion binding]; other site 588858000089 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 588858000090 Magnesium ion binding site [ion binding]; other site 588858000091 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 588858000092 ParB-like nuclease domain; Region: ParBc; pfam02195 588858000093 ParB family; Region: ParB; pfam08775 588858000094 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 588858000095 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 588858000096 active site 588858000097 DNA binding site [nucleotide binding] 588858000098 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 588858000099 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 588858000100 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 588858000101 Catalytic site [active] 588858000102 putative methylase; Provisional; Region: PRK13699 588858000103 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 588858000104 Antirestriction protein; Region: Antirestrict; pfam03230 588858000105 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 588858000106 DNA polymerase III, theta subunit; Region: DNA_pol3_theta; pfam06440 588858000107 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 588858000108 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 588858000109 dimer interface [polypeptide binding]; other site 588858000110 ssDNA binding site [nucleotide binding]; other site 588858000111 tetramer (dimer of dimers) interface [polypeptide binding]; other site 588858000112 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 588858000113 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 588858000114 ParB-like nuclease domain; Region: ParBc; pfam02195 588858000115 Plasmid SOS inhibition protein (PsiB); Region: PsiB; pfam06290 588858000116 PsiA protein; Region: PsiA; pfam06952 588858000117 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 588858000118 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 588858000119 N-acetyl-D-glucosamine binding site [chemical binding]; other site 588858000120 catalytic residue [active] 588858000121 conjugal transfer protein TraM; Provisional; Region: PRK13713 588858000122 conjugal transfer transcriptional regulator TraJ; Provisional; Region: PRK13719 588858000123 conjugal transfer protein TraY; Provisional; Region: PRK13740 588858000124 conjugal transfer pilin subunit TraA; Provisional; Region: PRK13734 588858000125 conjugal transfer pilus assembly protein TraL; Provisional; Region: PRK13707 588858000126 conjugal transfer pilus assembly protein TraE; Provisional; Region: PRK13726 588858000127 conjugal transfer protein TraK; Provisional; Region: PRK13736 588858000128 TraK protein; Region: TraK; pfam06586 588858000129 conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729 588858000130 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 588858000131 TraP protein; Region: TraP; pfam07296 588858000132 conjugal transfer protein TrbD; Provisional; Region: PRK13724 588858000133 NTPase; Region: NTPase_1; cl17478 588858000134 conjugal transfer protein TraV; Provisional; Region: PRK13733 588858000135 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 588858000136 conjugal transfer protein TraR; Provisional; Region: PRK13715 588858000137 conjugal transfer ATP-binding protein TraC; Provisional; Region: PRK13721 588858000138 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 588858000139 Domain of unknown function DUF87; Region: DUF87; pfam01935 588858000140 conjugal transfer protein TrbI; Provisional; Region: PRK13717 588858000141 conjugal transfer pilus assembly protein TraW; Provisional; Region: PRK13738 588858000142 conjugal transfer pilus assembly protein TraU; Provisional; Region: PRK13737 588858000143 conjugal transfer pilus assembly protein TrbC; Provisional; Region: PRK13730 588858000144 conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355 588858000145 conjugal transfer protein TrbE; Provisional; Region: PRK13718 588858000146 conjugal pilus assembly protein TraF; Provisional; Region: PRK13703 588858000147 F plasmid transfer operon protein; Region: TraF; pfam13728 588858000148 conjugal transfer pilin chaperone TraQ; Provisional; Region: PRK13727 588858000149 conjugal transfer protein TrbB; Provisional; Region: PRK13728 588858000150 conjugal transfer pilus assembly protein TraH; Provisional; Region: PRK13723 588858000151 conjugal transfer mating pair stabilization protein TraG; Provisional; Region: PRK13735 588858000152 Plasmid conjugative transfer entry exclusion protein TraS; Region: TraS; pfam10624 588858000153 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 588858000154 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 588858000155 conjugal transfer protein TraD; Provisional; Region: PRK13700 588858000156 F sex factor protein N terminal; Region: TraD_N; pfam12615 588858000157 Bacterial conjugation protein TrwB, ATP binding domain. TrwB is a homohexamer encoded by conjugative plasmids in Gram-negative bacteria. TrwB also has an all alpha domain which has been hypothesized to be responsible for DNA binding. TrwB is a component...; Region: TrwB; cd01127 588858000158 multimer interface [polypeptide binding]; other site 588858000159 Walker A motif; other site 588858000160 ATP binding site [chemical binding]; other site 588858000161 Walker B motif; other site 588858000162 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 588858000163 oligomeric interface; other site 588858000164 putative active site [active] 588858000165 homodimer interface [polypeptide binding]; other site 588858000166 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 588858000167 conjugal transfer nickase/helicase TraI; Provisional; Region: PRK13709 588858000168 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 588858000169 AAA domain; Region: AAA_30; pfam13604 588858000170 DNA helicase TraI; Region: TraI; pfam07057 588858000171 conjugal transfer pilus acetylation protein TraX; Provisional; Region: PRK13706 588858000172 conjugal transfer fertility inhibition protein FinO; Provisional; Region: PRK13754 588858000173 Fertility inhibition protein N terminal; Region: FinO_N; pfam12602 588858000174 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236 588858000175 putative kissing complex interaction region; other site 588858000176 putative RNA binding sites [nucleotide binding]; other site 588858000177 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 588858000178 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 588858000179 putative catalytic residues [active] 588858000180 putative nucleotide binding site [chemical binding]; other site 588858000181 putative aspartate binding site [chemical binding]; other site 588858000182 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 588858000183 dimer interface [polypeptide binding]; other site 588858000184 putative threonine allosteric regulatory site; other site 588858000185 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 588858000186 putative threonine allosteric regulatory site; other site 588858000187 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 588858000188 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 588858000189 homoserine kinase; Provisional; Region: PRK01212 588858000190 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 588858000191 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 588858000192 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 588858000193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858000194 catalytic residue [active] 588858000195 hypothetical protein; Validated; Region: PRK02101 588858000196 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 588858000197 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 588858000198 transaldolase-like protein; Provisional; Region: PTZ00411 588858000199 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 588858000200 active site 588858000201 dimer interface [polypeptide binding]; other site 588858000202 catalytic residue [active] 588858000203 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 588858000204 MPT binding site; other site 588858000205 trimer interface [polypeptide binding]; other site 588858000206 hypothetical protein; Provisional; Region: PRK10659 588858000207 hypothetical protein; Provisional; Region: PRK10236 588858000208 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 588858000209 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 588858000210 Protein of unknown function (DUF2541); Region: DUF2541; pfam10807 588858000211 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 588858000212 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 588858000213 nucleotide binding site [chemical binding]; other site 588858000214 chaperone protein DnaJ; Provisional; Region: PRK10767 588858000215 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 588858000216 HSP70 interaction site [polypeptide binding]; other site 588858000217 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 588858000218 substrate binding site [polypeptide binding]; other site 588858000219 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 588858000220 Zn binding sites [ion binding]; other site 588858000221 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 588858000222 dimer interface [polypeptide binding]; other site 588858000223 Transcriptional regulator [Transcription]; Region: LysR; COG0583 588858000224 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858000225 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 588858000226 substrate binding pocket [chemical binding]; other site 588858000227 dimerization interface [polypeptide binding]; other site 588858000228 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 588858000229 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 588858000230 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 588858000231 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 588858000232 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 588858000233 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 588858000234 active site 588858000235 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 588858000236 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 588858000237 aromatic chitin/cellulose binding site residues [chemical binding]; other site 588858000238 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 588858000239 Helix-turn-helix domain; Region: HTH_36; pfam13730 588858000240 fimbrial protein BcfA; Provisional; Region: PRK15187 588858000241 fimbrial chaperone protein BcfB; Provisional; Region: PRK15188 588858000242 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 588858000243 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 588858000244 outer membrane usher protein; Provisional; Region: PRK15193 588858000245 PapC N-terminal domain; Region: PapC_N; pfam13954 588858000246 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 588858000247 PapC C-terminal domain; Region: PapC_C; pfam13953 588858000248 fimbrial protein BcfD; Provisional; Region: PRK15189 588858000249 fimbrial protein BcfE; Provisional; Region: PRK15190 588858000250 fimbrial protein BcfF; Provisional; Region: PRK15191 588858000251 fimbrial chaperone BcfG; Provisional; Region: PRK15192 588858000252 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 588858000253 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 588858000254 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 588858000255 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 588858000256 catalytic residues [active] 588858000257 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 588858000258 Transcriptional regulator [Transcription]; Region: LysR; COG0583 588858000259 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858000260 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 588858000261 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 588858000262 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 588858000263 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 588858000264 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 588858000265 active site 588858000266 metal binding site [ion binding]; metal-binding site 588858000267 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 588858000268 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502 588858000269 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 588858000270 Sulfatase; Region: Sulfatase; pfam00884 588858000271 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 588858000272 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 588858000273 FeS/SAM binding site; other site 588858000274 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 588858000275 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 588858000276 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 588858000277 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 588858000278 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 588858000279 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858000280 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 588858000281 putative dimerization interface [polypeptide binding]; other site 588858000282 putative alpha-glucosidase; Provisional; Region: PRK10658 588858000283 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 588858000284 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 588858000285 putative active site [active] 588858000286 putative catalytic site [active] 588858000287 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 588858000288 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 588858000289 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 588858000290 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 588858000291 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 588858000292 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 588858000293 active site 588858000294 Riboflavin kinase; Region: Flavokinase; smart00904 588858000295 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 588858000296 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 588858000297 active site 588858000298 HIGH motif; other site 588858000299 nucleotide binding site [chemical binding]; other site 588858000300 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 588858000301 active site 588858000302 KMSKS motif; other site 588858000303 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 588858000304 tRNA binding surface [nucleotide binding]; other site 588858000305 anticodon binding site; other site 588858000306 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 588858000307 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 588858000308 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 588858000309 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 588858000310 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 588858000311 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 588858000312 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 588858000313 active site 588858000314 tetramer interface [polypeptide binding]; other site 588858000315 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 588858000316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 588858000317 active site 588858000318 phosphorylation site [posttranslational modification] 588858000319 intermolecular recognition site; other site 588858000320 dimerization interface [polypeptide binding]; other site 588858000321 Transcriptional regulator; Region: CitT; pfam12431 588858000322 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 588858000323 PAS domain; Region: PAS; smart00091 588858000324 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 588858000325 ATP binding site [chemical binding]; other site 588858000326 Mg2+ binding site [ion binding]; other site 588858000327 G-X-G motif; other site 588858000328 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 588858000329 oxaloacetate decarboxylase; Provisional; Region: PRK14040 588858000330 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 588858000331 active site 588858000332 catalytic residues [active] 588858000333 metal binding site [ion binding]; metal-binding site 588858000334 homodimer binding site [polypeptide binding]; other site 588858000335 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 588858000336 carboxyltransferase (CT) interaction site; other site 588858000337 biotinylation site [posttranslational modification]; other site 588858000338 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 588858000339 Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493 588858000340 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 588858000341 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 588858000342 putative active site [active] 588858000343 (T/H)XGH motif; other site 588858000344 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 588858000345 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 588858000346 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 588858000347 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 588858000348 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 588858000349 triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125 588858000350 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 588858000351 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 588858000352 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 588858000353 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 588858000354 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 588858000355 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 588858000356 catalytic site [active] 588858000357 subunit interface [polypeptide binding]; other site 588858000358 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 588858000359 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 588858000360 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 588858000361 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 588858000362 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 588858000363 ATP-grasp domain; Region: ATP-grasp_4; cl17255 588858000364 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 588858000365 IMP binding site; other site 588858000366 dimer interface [polypeptide binding]; other site 588858000367 interdomain contacts; other site 588858000368 partial ornithine binding site; other site 588858000369 Transposase IS200 like; Region: Y1_Tnp; pfam01797 588858000370 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 588858000371 carnitine operon protein CaiE; Provisional; Region: PRK13627 588858000372 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 588858000373 putative trimer interface [polypeptide binding]; other site 588858000374 putative metal binding site [ion binding]; other site 588858000375 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 588858000376 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 588858000377 substrate binding site [chemical binding]; other site 588858000378 oxyanion hole (OAH) forming residues; other site 588858000379 trimer interface [polypeptide binding]; other site 588858000380 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 588858000381 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 588858000382 acyl-activating enzyme (AAE) consensus motif; other site 588858000383 putative AMP binding site [chemical binding]; other site 588858000384 putative active site [active] 588858000385 putative CoA binding site [chemical binding]; other site 588858000386 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 588858000387 CoA-transferase family III; Region: CoA_transf_3; pfam02515 588858000388 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 588858000389 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 588858000390 active site 588858000391 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 588858000392 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 588858000393 Ligand binding site [chemical binding]; other site 588858000394 Electron transfer flavoprotein domain; Region: ETF; pfam01012 588858000395 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 588858000396 Electron transfer flavoprotein domain; Region: ETF; smart00893 588858000397 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 588858000398 putative oxidoreductase FixC; Provisional; Region: PRK10157 588858000399 ferredoxin-like protein FixX; Provisional; Region: PRK15449 588858000400 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858000401 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 588858000402 putative substrate translocation pore; other site 588858000403 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 588858000404 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 588858000405 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 588858000406 Sulfatase; Region: Sulfatase; cl17466 588858000407 Sulfatase; Region: Sulfatase; cl17466 588858000408 Sulfatase; Region: Sulfatase; cl17466 588858000409 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 588858000410 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 588858000411 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 588858000412 TrkA-N domain; Region: TrkA_N; pfam02254 588858000413 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 588858000414 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 588858000415 folate binding site [chemical binding]; other site 588858000416 NADP+ binding site [chemical binding]; other site 588858000417 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 588858000418 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 588858000419 active site 588858000420 metal binding site [ion binding]; metal-binding site 588858000421 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 588858000422 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 588858000423 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 588858000424 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 588858000425 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 588858000426 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 588858000427 SurA N-terminal domain; Region: SurA_N; pfam09312 588858000428 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 588858000429 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 588858000430 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 588858000431 OstA-like protein; Region: OstA; pfam03968 588858000432 Organic solvent tolerance protein; Region: OstA_C; pfam04453 588858000433 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 588858000434 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 588858000435 putative metal binding site [ion binding]; other site 588858000436 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 588858000437 HSP70 interaction site [polypeptide binding]; other site 588858000438 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 588858000439 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 588858000440 active site 588858000441 ATP-dependent helicase HepA; Validated; Region: PRK04914 588858000442 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 588858000443 ATP binding site [chemical binding]; other site 588858000444 putative Mg++ binding site [ion binding]; other site 588858000445 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 588858000446 nucleotide binding region [chemical binding]; other site 588858000447 ATP-binding site [chemical binding]; other site 588858000448 DNA polymerase II; Reviewed; Region: PRK05762 588858000449 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 588858000450 active site 588858000451 catalytic site [active] 588858000452 substrate binding site [chemical binding]; other site 588858000453 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 588858000454 active site 588858000455 metal-binding site 588858000456 Uncharacterized conserved protein [Function unknown]; Region: COG1434 588858000457 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 588858000458 putative active site [active] 588858000459 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 588858000460 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 588858000461 intersubunit interface [polypeptide binding]; other site 588858000462 active site 588858000463 Zn2+ binding site [ion binding]; other site 588858000464 L-arabinose isomerase; Provisional; Region: PRK02929 588858000465 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 588858000466 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 588858000467 trimer interface [polypeptide binding]; other site 588858000468 putative substrate binding site [chemical binding]; other site 588858000469 putative metal binding site [ion binding]; other site 588858000470 ribulokinase; Provisional; Region: PRK04123 588858000471 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 588858000472 N- and C-terminal domain interface [polypeptide binding]; other site 588858000473 active site 588858000474 MgATP binding site [chemical binding]; other site 588858000475 catalytic site [active] 588858000476 metal binding site [ion binding]; metal-binding site 588858000477 carbohydrate binding site [chemical binding]; other site 588858000478 homodimer interface [polypeptide binding]; other site 588858000479 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 588858000480 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 588858000481 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 588858000482 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 588858000483 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 588858000484 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 588858000485 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 588858000486 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 588858000487 Walker A/P-loop; other site 588858000488 ATP binding site [chemical binding]; other site 588858000489 Q-loop/lid; other site 588858000490 ABC transporter signature motif; other site 588858000491 Walker B; other site 588858000492 D-loop; other site 588858000493 H-loop/switch region; other site 588858000494 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 588858000495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858000496 dimer interface [polypeptide binding]; other site 588858000497 conserved gate region; other site 588858000498 putative PBP binding loops; other site 588858000499 ABC-ATPase subunit interface; other site 588858000500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858000501 dimer interface [polypeptide binding]; other site 588858000502 conserved gate region; other site 588858000503 putative PBP binding loops; other site 588858000504 ABC-ATPase subunit interface; other site 588858000505 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 588858000506 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 588858000507 transcriptional regulator SgrR; Provisional; Region: PRK13626 588858000508 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 588858000509 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 588858000510 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 588858000511 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 588858000512 substrate binding site [chemical binding]; other site 588858000513 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 588858000514 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 588858000515 substrate binding site [chemical binding]; other site 588858000516 ligand binding site [chemical binding]; other site 588858000517 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 588858000518 tartrate dehydrogenase; Region: TTC; TIGR02089 588858000519 2-isopropylmalate synthase; Validated; Region: PRK00915 588858000520 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 588858000521 active site 588858000522 catalytic residues [active] 588858000523 metal binding site [ion binding]; metal-binding site 588858000524 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 588858000525 leu operon leader peptide; Provisional; Region: PRK14744 588858000526 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 588858000527 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858000528 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 588858000529 putative substrate binding pocket [chemical binding]; other site 588858000530 putative dimerization interface [polypeptide binding]; other site 588858000531 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 588858000532 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 588858000533 dimer interface [polypeptide binding]; other site 588858000534 PYR/PP interface [polypeptide binding]; other site 588858000535 TPP binding site [chemical binding]; other site 588858000536 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 588858000537 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 588858000538 TPP-binding site [chemical binding]; other site 588858000539 dimer interface [polypeptide binding]; other site 588858000540 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 588858000541 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 588858000542 putative valine binding site [chemical binding]; other site 588858000543 dimer interface [polypeptide binding]; other site 588858000544 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 588858000545 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 588858000546 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 588858000547 DNA binding site [nucleotide binding] 588858000548 domain linker motif; other site 588858000549 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 588858000550 dimerization interface [polypeptide binding]; other site 588858000551 ligand binding site [chemical binding]; other site 588858000552 mraZ protein; Region: TIGR00242 588858000553 MraZ protein; Region: MraZ; pfam02381 588858000554 MraZ protein; Region: MraZ; pfam02381 588858000555 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 588858000556 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 588858000557 cell division protein FtsL; Provisional; Region: PRK10772 588858000558 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 588858000559 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 588858000560 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 588858000561 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 588858000562 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 588858000563 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 588858000564 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 588858000565 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 588858000566 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 588858000567 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 588858000568 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 588858000569 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 588858000570 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 588858000571 Mg++ binding site [ion binding]; other site 588858000572 putative catalytic motif [active] 588858000573 putative substrate binding site [chemical binding]; other site 588858000574 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 588858000575 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 588858000576 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 588858000577 cell division protein FtsW; Provisional; Region: PRK10774 588858000578 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 588858000579 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 588858000580 active site 588858000581 homodimer interface [polypeptide binding]; other site 588858000582 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 588858000583 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 588858000584 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 588858000585 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 588858000586 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 588858000587 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 588858000588 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 588858000589 cell division protein FtsQ; Provisional; Region: PRK10775 588858000590 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 588858000591 Cell division protein FtsQ; Region: FtsQ; pfam03799 588858000592 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 588858000593 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 588858000594 Cell division protein FtsA; Region: FtsA; pfam14450 588858000595 cell division protein FtsZ; Validated; Region: PRK09330 588858000596 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 588858000597 nucleotide binding site [chemical binding]; other site 588858000598 SulA interaction site; other site 588858000599 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 588858000600 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 588858000601 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 588858000602 SecA regulator SecM; Provisional; Region: PRK02943 588858000603 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 588858000604 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 588858000605 SEC-C motif; Region: SEC-C; pfam02810 588858000606 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 588858000607 active site 588858000608 8-oxo-dGMP binding site [chemical binding]; other site 588858000609 nudix motif; other site 588858000610 metal binding site [ion binding]; metal-binding site 588858000612 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 588858000613 DNA gyrase inhibitor; Reviewed; Region: PRK00418 588858000614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 588858000615 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 588858000616 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 588858000617 CoA-binding site [chemical binding]; other site 588858000618 ATP-binding [chemical binding]; other site 588858000619 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 588858000620 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 588858000621 active site 588858000622 type IV pilin biogenesis protein; Provisional; Region: PRK10573 588858000623 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 588858000624 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 588858000625 hypothetical protein; Provisional; Region: PRK10436 588858000626 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 588858000627 Walker A motif; other site 588858000628 ATP binding site [chemical binding]; other site 588858000629 Walker B motif; other site 588858000630 putative major pilin subunit; Provisional; Region: PRK10574 588858000631 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 588858000632 Pilin (bacterial filament); Region: Pilin; pfam00114 588858000633 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 588858000634 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 588858000635 dimerization interface [polypeptide binding]; other site 588858000636 active site 588858000637 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 588858000638 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 588858000639 amidase catalytic site [active] 588858000640 Zn binding residues [ion binding]; other site 588858000641 substrate binding site [chemical binding]; other site 588858000642 regulatory protein AmpE; Provisional; Region: PRK10987 588858000643 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 588858000644 active site 588858000645 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 588858000646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858000647 putative substrate translocation pore; other site 588858000648 aromatic amino acid transporter; Provisional; Region: PRK10238 588858000649 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 588858000650 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 588858000651 DNA-binding site [nucleotide binding]; DNA binding site 588858000652 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 588858000653 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 588858000654 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 588858000655 dimer interface [polypeptide binding]; other site 588858000656 TPP-binding site [chemical binding]; other site 588858000657 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 588858000658 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 588858000659 E3 interaction surface; other site 588858000660 lipoyl attachment site [posttranslational modification]; other site 588858000661 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 588858000662 E3 interaction surface; other site 588858000663 lipoyl attachment site [posttranslational modification]; other site 588858000664 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 588858000665 E3 interaction surface; other site 588858000666 lipoyl attachment site [posttranslational modification]; other site 588858000667 e3 binding domain; Region: E3_binding; pfam02817 588858000668 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 588858000669 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 588858000670 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 588858000671 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 588858000672 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 588858000673 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 588858000674 similar to Escherichia coli putative membrane protein (AAC73228.1); disrupted by frameshift 588858000675 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 588858000676 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 588858000677 substrate binding site [chemical binding]; other site 588858000678 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 588858000679 substrate binding site [chemical binding]; other site 588858000680 ligand binding site [chemical binding]; other site 588858000681 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 588858000682 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 588858000683 hypothetical protein; Provisional; Region: PRK05248 588858000684 2-keto-3-deoxygluconate permease; Provisional; Region: PRK12460 588858000685 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 588858000686 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 588858000687 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 588858000688 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 588858000689 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 588858000690 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 588858000691 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 588858000692 spermidine synthase; Provisional; Region: PRK00811 588858000693 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 588858000694 S-adenosylmethionine binding site [chemical binding]; other site 588858000695 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 588858000696 multicopper oxidase; Provisional; Region: PRK10965 588858000697 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 588858000698 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 588858000699 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 588858000700 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 588858000701 Trp docking motif [polypeptide binding]; other site 588858000702 putative active site [active] 588858000703 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 588858000704 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 588858000705 active site 588858000706 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 588858000707 active site clefts [active] 588858000708 zinc binding site [ion binding]; other site 588858000709 dimer interface [polypeptide binding]; other site 588858000710 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 588858000711 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 588858000712 Walker A/P-loop; other site 588858000713 ATP binding site [chemical binding]; other site 588858000714 Q-loop/lid; other site 588858000715 ABC transporter signature motif; other site 588858000716 Walker B; other site 588858000717 D-loop; other site 588858000718 H-loop/switch region; other site 588858000719 inner membrane transport permease; Provisional; Region: PRK15066 588858000720 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 588858000721 putative fimbrial protein StiH; Provisional; Region: PRK15297 588858000722 fimbrial outer membrane usher protein StiC; Provisional; Region: PRK15298 588858000723 PapC N-terminal domain; Region: PapC_N; pfam13954 588858000724 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 588858000725 PapC C-terminal domain; Region: PapC_C; pfam13953 588858000726 fimbrial chaperone protein StiB; Provisional; Region: PRK15299 588858000727 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 588858000728 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 588858000729 fimbrial protein StiA; Provisional; Region: PRK15300 588858000730 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 588858000731 active pocket/dimerization site; other site 588858000732 active site 588858000733 phosphorylation site [posttranslational modification] 588858000734 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 588858000735 putative active site [active] 588858000736 putative metal binding site [ion binding]; other site 588858000737 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 588858000738 tetramerization interface [polypeptide binding]; other site 588858000739 active site 588858000740 Pantoate-beta-alanine ligase; Region: PanC; cd00560 588858000741 pantoate--beta-alanine ligase; Region: panC; TIGR00018 588858000742 active site 588858000743 ATP-binding site [chemical binding]; other site 588858000744 pantoate-binding site; other site 588858000745 HXXH motif; other site 588858000746 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 588858000747 oligomerization interface [polypeptide binding]; other site 588858000748 active site 588858000749 metal binding site [ion binding]; metal-binding site 588858000750 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 588858000751 catalytic center binding site [active] 588858000752 ATP binding site [chemical binding]; other site 588858000753 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 588858000754 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 588858000755 active site 588858000756 NTP binding site [chemical binding]; other site 588858000757 metal binding triad [ion binding]; metal-binding site 588858000758 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 588858000759 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 588858000760 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 588858000761 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 588858000762 active site 588858000763 nucleotide binding site [chemical binding]; other site 588858000764 HIGH motif; other site 588858000765 KMSKS motif; other site 588858000766 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 588858000767 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 588858000768 2'-5' RNA ligase; Provisional; Region: PRK15124 588858000769 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 588858000770 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 588858000771 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 588858000772 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 588858000773 ATP binding site [chemical binding]; other site 588858000774 putative Mg++ binding site [ion binding]; other site 588858000775 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 588858000776 nucleotide binding region [chemical binding]; other site 588858000777 ATP-binding site [chemical binding]; other site 588858000778 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 588858000779 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 588858000780 Transglycosylase; Region: Transgly; pfam00912 588858000781 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 588858000782 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 588858000783 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 588858000784 N-terminal plug; other site 588858000785 ligand-binding site [chemical binding]; other site 588858000786 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 588858000787 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 588858000788 Walker A/P-loop; other site 588858000789 ATP binding site [chemical binding]; other site 588858000790 Q-loop/lid; other site 588858000791 ABC transporter signature motif; other site 588858000792 Walker B; other site 588858000793 D-loop; other site 588858000794 H-loop/switch region; other site 588858000795 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 588858000796 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 588858000797 siderophore binding site; other site 588858000798 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 588858000799 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 588858000800 ABC-ATPase subunit interface; other site 588858000801 dimer interface [polypeptide binding]; other site 588858000802 putative PBP binding regions; other site 588858000803 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 588858000804 ABC-ATPase subunit interface; other site 588858000805 dimer interface [polypeptide binding]; other site 588858000806 putative PBP binding regions; other site 588858000807 putative fimbrial subunit StfA; Provisional; Region: PRK15283 588858000808 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 588858000809 PapC N-terminal domain; Region: PapC_N; pfam13954 588858000810 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 588858000811 PapC C-terminal domain; Region: PapC_C; pfam13953 588858000812 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 588858000813 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 588858000814 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 588858000815 putative minor fimbrial subunit StfE; Provisional; Region: PRK15286 588858000816 putative minor fimbrial subunit StfF; Provisional; Region: PRK15287 588858000817 putative minor fimbrial subunit StfG; Provisional; Region: PRK15288 588858000818 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 588858000819 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 588858000820 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 588858000821 inhibitor-cofactor binding pocket; inhibition site 588858000822 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858000823 catalytic residue [active] 588858000824 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 588858000825 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 588858000826 Cl- selectivity filter; other site 588858000827 Cl- binding residues [ion binding]; other site 588858000828 pore gating glutamate residue; other site 588858000829 dimer interface [polypeptide binding]; other site 588858000830 H+/Cl- coupling transport residue; other site 588858000831 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 588858000832 hypothetical protein; Provisional; Region: PRK10578 588858000833 UPF0126 domain; Region: UPF0126; pfam03458 588858000834 UPF0126 domain; Region: UPF0126; pfam03458 588858000835 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 588858000836 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 588858000837 cobalamin binding residues [chemical binding]; other site 588858000838 putative BtuC binding residues; other site 588858000839 dimer interface [polypeptide binding]; other site 588858000840 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 588858000841 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 588858000842 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 588858000843 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 588858000844 Zn2+ binding site [ion binding]; other site 588858000845 Mg2+ binding site [ion binding]; other site 588858000846 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 588858000847 serine endoprotease; Provisional; Region: PRK10942 588858000848 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 588858000849 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 588858000850 protein binding site [polypeptide binding]; other site 588858000851 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 588858000852 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 588858000853 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 588858000854 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 588858000855 hypothetical protein; Provisional; Region: PRK13677 588858000856 similar to Escherichia coli putative transport protein; shikimate (AAC75045.1); disrupted by frameshift 588858000857 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 588858000858 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 588858000859 trimer interface [polypeptide binding]; other site 588858000860 active site 588858000861 substrate binding site [chemical binding]; other site 588858000862 CoA binding site [chemical binding]; other site 588858000863 PII uridylyl-transferase; Provisional; Region: PRK05007 588858000864 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 588858000865 metal binding triad; other site 588858000866 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 588858000867 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 588858000868 Zn2+ binding site [ion binding]; other site 588858000869 Mg2+ binding site [ion binding]; other site 588858000870 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 588858000871 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 588858000872 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 588858000873 active site 588858000874 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 588858000875 rRNA interaction site [nucleotide binding]; other site 588858000876 S8 interaction site; other site 588858000877 putative laminin-1 binding site; other site 588858000878 elongation factor Ts; Provisional; Region: tsf; PRK09377 588858000879 UBA/TS-N domain; Region: UBA; pfam00627 588858000880 Elongation factor TS; Region: EF_TS; pfam00889 588858000881 Elongation factor TS; Region: EF_TS; pfam00889 588858000882 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 588858000883 putative nucleotide binding site [chemical binding]; other site 588858000884 uridine monophosphate binding site [chemical binding]; other site 588858000885 homohexameric interface [polypeptide binding]; other site 588858000886 ribosome recycling factor; Reviewed; Region: frr; PRK00083 588858000887 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 588858000888 hinge region; other site 588858000889 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 588858000890 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 588858000891 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 588858000892 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 588858000893 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 588858000894 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 588858000895 catalytic residue [active] 588858000896 putative FPP diphosphate binding site; other site 588858000897 putative FPP binding hydrophobic cleft; other site 588858000898 dimer interface [polypeptide binding]; other site 588858000899 putative IPP diphosphate binding site; other site 588858000900 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 588858000901 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 588858000902 zinc metallopeptidase RseP; Provisional; Region: PRK10779 588858000903 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 588858000904 active site 588858000905 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 588858000906 protein binding site [polypeptide binding]; other site 588858000907 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 588858000908 protein binding site [polypeptide binding]; other site 588858000909 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 588858000910 putative substrate binding region [chemical binding]; other site 588858000911 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 588858000912 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 588858000913 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 588858000914 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 588858000915 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 588858000916 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 588858000917 Surface antigen; Region: Bac_surface_Ag; pfam01103 588858000918 periplasmic chaperone; Provisional; Region: PRK10780 588858000919 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 588858000920 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 588858000921 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 588858000922 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 588858000923 trimer interface [polypeptide binding]; other site 588858000924 active site 588858000925 UDP-GlcNAc binding site [chemical binding]; other site 588858000926 lipid binding site [chemical binding]; lipid-binding site 588858000927 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 588858000928 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 588858000929 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 588858000930 active site 588858000931 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 588858000932 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 588858000933 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 588858000934 RNA/DNA hybrid binding site [nucleotide binding]; other site 588858000935 active site 588858000936 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 588858000937 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 588858000938 putative active site [active] 588858000939 putative PHP Thumb interface [polypeptide binding]; other site 588858000940 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 588858000941 generic binding surface II; other site 588858000942 generic binding surface I; other site 588858000943 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 588858000944 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 588858000945 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 588858000946 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 588858000947 putative sugar binding site [chemical binding]; other site 588858000948 catalytic residues [active] 588858000949 PKD domain; Region: PKD; pfam00801 588858000950 lysine decarboxylase LdcC; Provisional; Region: PRK15399 588858000951 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 588858000952 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 588858000953 homodimer interface [polypeptide binding]; other site 588858000954 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858000955 catalytic residue [active] 588858000956 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 588858000957 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 588858000958 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 588858000959 putative metal binding site [ion binding]; other site 588858000960 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 588858000961 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 588858000962 Ligand Binding Site [chemical binding]; other site 588858000963 TilS substrate binding domain; Region: TilS; pfam09179 588858000964 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 588858000965 Rho-binding antiterminator; Provisional; Region: PRK11625 588858000966 hypothetical protein; Provisional; Region: PRK04964 588858000967 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 588858000968 hypothetical protein; Provisional; Region: PRK09256 588858000969 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 588858000971 prolyl-tRNA synthetase; Provisional; Region: PRK09194 588858000972 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 588858000973 dimer interface [polypeptide binding]; other site 588858000974 motif 1; other site 588858000975 active site 588858000976 motif 2; other site 588858000977 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 588858000978 putative deacylase active site [active] 588858000979 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 588858000980 active site 588858000981 motif 3; other site 588858000982 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 588858000983 anticodon binding site; other site 588858000984 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 588858000985 homodimer interaction site [polypeptide binding]; other site 588858000986 cofactor binding site; other site 588858000987 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 588858000988 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 588858000989 lipoprotein, YaeC family; Region: TIGR00363 588858000990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858000991 dimer interface [polypeptide binding]; other site 588858000992 conserved gate region; other site 588858000993 ABC-ATPase subunit interface; other site 588858000994 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 588858000995 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 588858000996 Walker A/P-loop; other site 588858000997 ATP binding site [chemical binding]; other site 588858000998 Q-loop/lid; other site 588858000999 ABC transporter signature motif; other site 588858001000 Walker B; other site 588858001001 D-loop; other site 588858001002 H-loop/switch region; other site 588858001003 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 588858001004 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 588858001005 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 588858001006 active site 588858001007 motif I; other site 588858001008 motif II; other site 588858001009 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 588858001010 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 588858001011 active site 588858001012 catalytic tetrad [active] 588858001013 Transcriptional regulator [Transcription]; Region: LysR; COG0583 588858001014 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858001015 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 588858001016 putative effector binding pocket; other site 588858001017 dimerization interface [polypeptide binding]; other site 588858001018 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 588858001019 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858001020 putative substrate translocation pore; other site 588858001021 hypothetical protein; Provisional; Region: PRK05421 588858001022 putative catalytic site [active] 588858001023 putative metal binding site [ion binding]; other site 588858001024 putative phosphate binding site [ion binding]; other site 588858001025 putative catalytic site [active] 588858001026 putative phosphate binding site [ion binding]; other site 588858001027 putative metal binding site [ion binding]; other site 588858001028 Methyltransferase domain; Region: Methyltransf_23; pfam13489 588858001029 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 588858001030 S-adenosylmethionine binding site [chemical binding]; other site 588858001031 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 588858001032 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 588858001033 N-acetyl-D-glucosamine binding site [chemical binding]; other site 588858001034 catalytic residue [active] 588858001035 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 588858001036 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 588858001037 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 588858001038 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 588858001039 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 588858001040 RNA/DNA hybrid binding site [nucleotide binding]; other site 588858001041 active site 588858001042 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 588858001043 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 588858001044 active site 588858001045 catalytic site [active] 588858001046 substrate binding site [chemical binding]; other site 588858001047 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 588858001048 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 588858001049 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 588858001050 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 588858001051 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 588858001052 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 588858001053 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 588858001054 ImpE protein; Region: ImpE; pfam07024 588858001055 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 588858001056 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 588858001057 Walker A motif; other site 588858001058 ATP binding site [chemical binding]; other site 588858001059 Walker B motif; other site 588858001060 arginine finger; other site 588858001061 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 588858001062 Walker A motif; other site 588858001063 ATP binding site [chemical binding]; other site 588858001064 Walker B motif; other site 588858001065 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 588858001066 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 588858001067 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 588858001068 Protein of unknown function (DUF877); Region: DUF877; pfam05943 588858001069 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 588858001070 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 588858001071 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 588858001072 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 588858001073 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 588858001074 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 588858001075 hypothetical protein; Provisional; Region: PRK08126 588858001076 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 588858001077 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 588858001078 ligand binding site [chemical binding]; other site 588858001079 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 588858001080 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 588858001081 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 588858001082 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 588858001083 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4893 588858001084 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 588858001085 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 588858001086 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 588858001087 Uncharacterized conserved protein [Function unknown]; Region: COG5435 588858001088 PAAR motif; Region: PAAR_motif; pfam05488 588858001089 RHS Repeat; Region: RHS_repeat; pfam05593 588858001090 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 588858001091 RHS Repeat; Region: RHS_repeat; pfam05593 588858001092 RHS Repeat; Region: RHS_repeat; pfam05593 588858001093 RHS protein; Region: RHS; pfam03527 588858001094 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 588858001095 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 588858001096 RHS protein; Region: RHS; pfam03527 588858001097 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 588858001098 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 588858001099 Transposase; Region: HTH_Tnp_1; cl17663 588858001100 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 588858001101 Integrase core domain; Region: rve_3; pfam13683 588858001102 Saf-pilin pilus formation protein SafA; Provisional; Region: PRK15221 588858001103 pili assembly chaperone protein SafB; Provisional; Region: PRK15224 588858001104 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 588858001105 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 588858001106 pilin outer membrane usher protein SafC; Provisional; Region: PRK15223 588858001107 PapC N-terminal domain; Region: PapC_N; pfam13954 588858001108 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 588858001109 PapC C-terminal domain; Region: PapC_C; pfam13953 588858001110 putative pilin structural protein SafD; Provisional; Region: PRK15222 588858001111 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 588858001112 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 588858001113 putative active site [active] 588858001114 putative metal binding site [ion binding]; other site 588858001115 PerC transcriptional activator; Region: PerC; pfam06069 588858001116 Transcriptional regulator [Transcription]; Region: LysR; COG0583 588858001117 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858001118 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 588858001119 dimerization interface [polypeptide binding]; other site 588858001120 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 588858001121 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 588858001122 dimer interface [polypeptide binding]; other site 588858001123 C-N hydrolase family amidase; Provisional; Region: PRK10438 588858001124 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 588858001125 putative active site [active] 588858001126 catalytic triad [active] 588858001127 dimer interface [polypeptide binding]; other site 588858001128 multimer interface [polypeptide binding]; other site 588858001129 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 588858001130 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 588858001131 active site 588858001132 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 588858001133 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 588858001134 dimer interface [polypeptide binding]; other site 588858001135 active site 588858001136 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 588858001137 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 588858001138 putative active site [active] 588858001139 putative dimer interface [polypeptide binding]; other site 588858001140 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 588858001141 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 588858001142 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 588858001143 active site 588858001144 DNA polymerase IV; Validated; Region: PRK02406 588858001145 DNA binding site [nucleotide binding] 588858001146 pseudogene; frameshift relative to Escherichia coli probable peptide chain release factor (GB:AAC73340.1) 588858001147 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 588858001148 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 588858001149 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 588858001150 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 588858001151 metal binding site [ion binding]; metal-binding site 588858001152 dimer interface [polypeptide binding]; other site 588858001153 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 588858001154 active site 588858001155 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 588858001156 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 588858001157 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 588858001158 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 588858001159 trimer interface [polypeptide binding]; other site 588858001160 eyelet of channel; other site 588858001161 gamma-glutamyl kinase; Provisional; Region: PRK05429 588858001162 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 588858001163 nucleotide binding site [chemical binding]; other site 588858001164 homotetrameric interface [polypeptide binding]; other site 588858001165 putative phosphate binding site [ion binding]; other site 588858001166 putative allosteric binding site; other site 588858001167 PUA domain; Region: PUA; pfam01472 588858001168 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 588858001169 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 588858001170 putative catalytic cysteine [active] 588858001171 HTH-like domain; Region: HTH_21; pfam13276 588858001172 Integrase core domain; Region: rve; pfam00665 588858001173 Integrase core domain; Region: rve_2; pfam13333 588858001174 pseudogene; frameshift; putative HSP70 class molecular chaperone 588858001175 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 588858001176 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 588858001177 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858001178 putative substrate translocation pore; other site 588858001179 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 588858001180 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 588858001181 substrate binding site [chemical binding]; other site 588858001182 ligand binding site [chemical binding]; other site 588858001183 3-isopropylmalate dehydratase small subunit [Amino acid transport and metabolism]; Region: LeuD; COG0066 588858001184 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 588858001185 hypothetical protein; Provisional; Region: PRK14812 588858001186 substrate binding site [chemical binding]; other site 588858001187 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 588858001188 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 588858001189 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 588858001190 transcriptional activator TtdR; Provisional; Region: PRK09801 588858001191 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858001192 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 588858001193 putative effector binding pocket; other site 588858001194 putative dimerization interface [polypeptide binding]; other site 588858001195 YjzC-like protein; Region: YjzC; pfam14168 588858001196 fimbrial assembly chaperone StbE; Provisional; Region: PRK15246 588858001197 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 588858001198 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 588858001199 putative fimbrial usher protein StbD; Provisional; Region: PRK15247 588858001200 fimbrial outer membrane usher protein StbC; Provisional; Region: PRK15248 588858001201 PapC N-terminal domain; Region: PapC_N; pfam13954 588858001202 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 588858001203 PapC C-terminal domain; Region: PapC_C; pfam13953 588858001204 fimbrial chaperone protein StbB; Provisional; Region: PRK15249 588858001205 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 588858001206 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 588858001207 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 588858001208 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 588858001209 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 588858001210 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 588858001211 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 588858001212 DNA binding site [nucleotide binding] 588858001213 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 588858001214 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 588858001215 DNA binding residues [nucleotide binding] 588858001216 dimerization interface [polypeptide binding]; other site 588858001217 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 588858001218 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 588858001219 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 588858001220 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 588858001221 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 588858001222 HlyD family secretion protein; Region: HlyD_3; pfam13437 588858001223 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 588858001224 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 588858001225 metal-binding site [ion binding] 588858001226 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 588858001227 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 588858001228 motif II; other site 588858001229 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 588858001230 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 588858001231 DNA binding residues [nucleotide binding] 588858001232 dimer interface [polypeptide binding]; other site 588858001233 copper binding site [ion binding]; other site 588858001234 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 588858001235 metal-binding site [ion binding] 588858001236 putative sialic acid transporter; Region: 2A0112; TIGR00891 588858001237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858001238 putative substrate translocation pore; other site 588858001239 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 588858001240 DNA methylase; Region: N6_N4_Mtase; cl17433 588858001241 DNA methylase; Region: N6_N4_Mtase; pfam01555 588858001242 type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483 588858001243 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 588858001244 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 588858001245 VRR-NUC domain; Region: VRR_NUC; pfam08774 588858001246 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 588858001247 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 588858001248 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 588858001249 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 588858001250 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 588858001251 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 588858001252 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 588858001253 N-terminal plug; other site 588858001254 ligand-binding site [chemical binding]; other site 588858001255 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 588858001256 hypothetical protein; Provisional; Region: PRK09929 588858001257 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 588858001258 Propionate catabolism activator; Region: PrpR_N; pfam06506 588858001259 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 588858001260 Walker A motif; other site 588858001261 ATP binding site [chemical binding]; other site 588858001262 Walker B motif; other site 588858001263 arginine finger; other site 588858001264 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 588858001265 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 588858001266 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 588858001267 tetramer interface [polypeptide binding]; other site 588858001268 active site 588858001269 Mg2+/Mn2+ binding site [ion binding]; other site 588858001270 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 588858001271 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 588858001272 dimer interface [polypeptide binding]; other site 588858001273 active site 588858001274 citrylCoA binding site [chemical binding]; other site 588858001275 oxalacetate/citrate binding site [chemical binding]; other site 588858001276 coenzyme A binding site [chemical binding]; other site 588858001277 catalytic triad [active] 588858001278 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 588858001279 2-methylcitrate dehydratase; Region: prpD; TIGR02330 588858001280 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 588858001281 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 588858001282 acyl-activating enzyme (AAE) consensus motif; other site 588858001283 AMP binding site [chemical binding]; other site 588858001284 active site 588858001285 CoA binding site [chemical binding]; other site 588858001286 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 588858001287 dimer interface [polypeptide binding]; other site 588858001288 active site 588858001289 Schiff base residues; other site 588858001290 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 588858001291 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 588858001292 Autotransporter beta-domain; Region: Autotransporter; pfam03797 588858001293 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 588858001294 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 588858001295 ligand binding site [chemical binding]; other site 588858001296 flexible hinge region; other site 588858001297 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 588858001298 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 588858001299 microcin B17 transporter; Reviewed; Region: PRK11098 588858001300 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 588858001301 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 588858001302 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 588858001303 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 588858001304 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 588858001305 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 588858001306 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 588858001307 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 588858001308 drug efflux system protein MdtG; Provisional; Region: PRK09874 588858001309 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858001310 putative substrate translocation pore; other site 588858001311 anti-RssB factor; Provisional; Region: PRK10244 588858001312 hypothetical protein; Provisional; Region: PRK11505 588858001313 psiF repeat; Region: PsiF_repeat; pfam07769 588858001314 psiF repeat; Region: PsiF_repeat; pfam07769 588858001315 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 588858001316 MASE2 domain; Region: MASE2; pfam05230 588858001317 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 588858001318 metal binding site [ion binding]; metal-binding site 588858001319 active site 588858001320 I-site; other site 588858001321 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 588858001322 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 588858001323 hypothetical protein; Validated; Region: PRK00124 588858001324 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 588858001325 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 588858001326 ADP binding site [chemical binding]; other site 588858001327 magnesium binding site [ion binding]; other site 588858001328 putative shikimate binding site; other site 588858001329 hypothetical protein; Provisional; Region: PRK10380 588858001330 hypothetical protein; Provisional; Region: PRK10481 588858001331 hypothetical protein; Provisional; Region: PRK10579 588858001332 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 588858001333 fructokinase; Reviewed; Region: PRK09557 588858001334 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 588858001335 nucleotide binding site [chemical binding]; other site 588858001336 MFS transport protein AraJ; Provisional; Region: PRK10091 588858001337 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858001338 putative substrate translocation pore; other site 588858001339 exonuclease subunit SbcC; Provisional; Region: PRK10246 588858001340 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 588858001341 Walker A/P-loop; other site 588858001342 ATP binding site [chemical binding]; other site 588858001343 Q-loop/lid; other site 588858001344 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 588858001345 ABC transporter signature motif; other site 588858001346 Walker B; other site 588858001347 D-loop; other site 588858001348 H-loop/switch region; other site 588858001349 exonuclease subunit SbcD; Provisional; Region: PRK10966 588858001350 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 588858001351 active site 588858001352 metal binding site [ion binding]; metal-binding site 588858001353 DNA binding site [nucleotide binding] 588858001354 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 588858001355 transcriptional regulator PhoB; Provisional; Region: PRK10161 588858001356 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 588858001357 active site 588858001358 phosphorylation site [posttranslational modification] 588858001359 intermolecular recognition site; other site 588858001360 dimerization interface [polypeptide binding]; other site 588858001361 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 588858001362 DNA binding site [nucleotide binding] 588858001363 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 588858001364 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 588858001365 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 588858001366 putative active site [active] 588858001367 heme pocket [chemical binding]; other site 588858001368 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 588858001369 dimer interface [polypeptide binding]; other site 588858001370 phosphorylation site [posttranslational modification] 588858001371 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 588858001372 ATP binding site [chemical binding]; other site 588858001373 Mg2+ binding site [ion binding]; other site 588858001374 G-X-G motif; other site 588858001375 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 588858001376 putative proline-specific permease; Provisional; Region: proY; PRK10580 588858001377 maltodextrin glucosidase; Provisional; Region: PRK10785 588858001378 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 588858001379 homodimer interface [polypeptide binding]; other site 588858001380 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 588858001381 active site 588858001382 homodimer interface [polypeptide binding]; other site 588858001383 catalytic site [active] 588858001384 peroxidase; Provisional; Region: PRK15000 588858001385 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 588858001386 dimer interface [polypeptide binding]; other site 588858001387 decamer (pentamer of dimers) interface [polypeptide binding]; other site 588858001388 catalytic triad [active] 588858001389 peroxidatic and resolving cysteines [active] 588858001390 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 588858001391 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 588858001392 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 588858001393 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 588858001394 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 588858001395 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 588858001396 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 588858001397 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 588858001398 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 588858001399 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 588858001400 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 588858001401 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 588858001402 Protein export membrane protein; Region: SecD_SecF; pfam02355 588858001403 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 588858001404 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 588858001405 Predicted transcriptional regulator [Transcription]; Region: COG2378 588858001406 HTH domain; Region: HTH_11; pfam08279 588858001407 WYL domain; Region: WYL; pfam13280 588858001408 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 588858001409 active site 588858001410 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 588858001411 hypothetical protein; Provisional; Region: PRK11530 588858001412 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 588858001413 ATP cone domain; Region: ATP-cone; pfam03477 588858001414 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 588858001415 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 588858001416 catalytic motif [active] 588858001417 Zn binding site [ion binding]; other site 588858001418 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 588858001419 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 588858001420 homopentamer interface [polypeptide binding]; other site 588858001421 active site 588858001422 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 588858001423 putative RNA binding site [nucleotide binding]; other site 588858001424 thiamine monophosphate kinase; Provisional; Region: PRK05731 588858001425 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 588858001426 ATP binding site [chemical binding]; other site 588858001427 dimerization interface [polypeptide binding]; other site 588858001428 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 588858001429 tetramer interfaces [polypeptide binding]; other site 588858001430 binuclear metal-binding site [ion binding]; other site 588858001431 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 588858001432 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 588858001433 active site 588858001434 catalytic tetrad [active] 588858001435 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 588858001436 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 588858001437 TPP-binding site; other site 588858001438 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 588858001439 PYR/PP interface [polypeptide binding]; other site 588858001440 dimer interface [polypeptide binding]; other site 588858001441 TPP binding site [chemical binding]; other site 588858001442 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 588858001443 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 588858001444 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 588858001445 substrate binding pocket [chemical binding]; other site 588858001446 chain length determination region; other site 588858001447 substrate-Mg2+ binding site; other site 588858001448 catalytic residues [active] 588858001449 aspartate-rich region 1; other site 588858001450 active site lid residues [active] 588858001451 aspartate-rich region 2; other site 588858001452 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 588858001453 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 588858001454 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 588858001455 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 588858001456 Ligand Binding Site [chemical binding]; other site 588858001457 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 588858001458 active site residue [active] 588858001459 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 588858001460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858001461 dimer interface [polypeptide binding]; other site 588858001462 conserved gate region; other site 588858001463 ABC-ATPase subunit interface; other site 588858001464 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 588858001465 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858001466 dimer interface [polypeptide binding]; other site 588858001467 conserved gate region; other site 588858001468 putative PBP binding loops; other site 588858001469 ABC-ATPase subunit interface; other site 588858001470 2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258 588858001471 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 588858001472 Walker A/P-loop; other site 588858001473 ATP binding site [chemical binding]; other site 588858001474 Q-loop/lid; other site 588858001475 ABC transporter signature motif; other site 588858001476 Walker B; other site 588858001477 D-loop; other site 588858001478 H-loop/switch region; other site 588858001479 TOBE domain; Region: TOBE_2; pfam08402 588858001480 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 588858001481 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 588858001482 transcriptional regulator protein; Region: phnR; TIGR03337 588858001483 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 588858001484 DNA-binding site [nucleotide binding]; DNA binding site 588858001485 UTRA domain; Region: UTRA; pfam07702 588858001486 2-aminoethylphosphonate--pyruvate transaminase; Region: transamin_PhnW; TIGR02326 588858001487 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 588858001488 catalytic residue [active] 588858001489 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 588858001490 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 588858001491 motif II; other site 588858001492 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 588858001493 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 588858001494 conserved cys residue [active] 588858001495 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 588858001496 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 588858001497 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 588858001498 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 588858001499 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 588858001500 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858001501 Major Facilitator Superfamily; Region: MFS_1; pfam07690 588858001502 putative substrate translocation pore; other site 588858001503 Sel1-like repeats; Region: SEL1; smart00671 588858001504 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 588858001505 Sel1 repeat; Region: Sel1; pfam08238 588858001506 Sel1-like repeats; Region: SEL1; smart00671 588858001507 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 588858001508 Sel1-like repeats; Region: SEL1; smart00671 588858001509 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 588858001510 Sel1-like repeats; Region: SEL1; smart00671 588858001511 Sel1-like repeats; Region: SEL1; smart00671 588858001512 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 588858001513 UbiA prenyltransferase family; Region: UbiA; pfam01040 588858001514 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 588858001515 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 588858001516 Subunit I/III interface [polypeptide binding]; other site 588858001517 Subunit III/IV interface [polypeptide binding]; other site 588858001518 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 588858001519 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 588858001520 D-pathway; other site 588858001521 Putative ubiquinol binding site [chemical binding]; other site 588858001522 Low-spin heme (heme b) binding site [chemical binding]; other site 588858001523 Putative water exit pathway; other site 588858001524 Binuclear center (heme o3/CuB) [ion binding]; other site 588858001525 K-pathway; other site 588858001526 Putative proton exit pathway; other site 588858001527 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 588858001528 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 588858001529 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 588858001530 muropeptide transporter; Reviewed; Region: ampG; PRK11902 588858001531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858001532 putative substrate translocation pore; other site 588858001533 hypothetical protein; Provisional; Region: PRK11627 588858001534 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 588858001535 transcriptional regulator BolA; Provisional; Region: PRK11628 588858001536 trigger factor; Provisional; Region: tig; PRK01490 588858001537 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 588858001538 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 588858001539 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 588858001540 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 588858001541 oligomer interface [polypeptide binding]; other site 588858001542 active site residues [active] 588858001543 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 588858001544 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 588858001545 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 588858001546 Walker A motif; other site 588858001547 ATP binding site [chemical binding]; other site 588858001548 Walker B motif; other site 588858001549 Iron permease FTR1 family; Region: FTR1; cl00475 588858001550 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 588858001551 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 588858001552 Found in ATP-dependent protease La (LON); Region: LON; smart00464 588858001553 Found in ATP-dependent protease La (LON); Region: LON; smart00464 588858001554 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 588858001555 Walker A motif; other site 588858001556 ATP binding site [chemical binding]; other site 588858001557 Walker B motif; other site 588858001558 arginine finger; other site 588858001559 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 588858001560 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 588858001561 IHF dimer interface [polypeptide binding]; other site 588858001562 IHF - DNA interface [nucleotide binding]; other site 588858001563 periplasmic folding chaperone; Provisional; Region: PRK10788 588858001564 SurA N-terminal domain; Region: SurA_N_3; cl07813 588858001565 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 588858001566 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 588858001567 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 588858001568 active site 588858001569 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 588858001570 Ligand Binding Site [chemical binding]; other site 588858001571 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 588858001572 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 588858001573 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 588858001574 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 588858001575 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 588858001576 active site 588858001577 motif I; other site 588858001578 motif II; other site 588858001579 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 588858001580 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 588858001581 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 588858001582 catalytic residue [active] 588858001583 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 588858001584 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 588858001585 putative DNA binding site [nucleotide binding]; other site 588858001586 putative Zn2+ binding site [ion binding]; other site 588858001587 AsnC family; Region: AsnC_trans_reg; pfam01037 588858001588 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 588858001589 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 588858001590 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 588858001591 Walker A/P-loop; other site 588858001592 ATP binding site [chemical binding]; other site 588858001593 Q-loop/lid; other site 588858001594 ABC transporter signature motif; other site 588858001595 Walker B; other site 588858001596 D-loop; other site 588858001597 H-loop/switch region; other site 588858001598 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 588858001599 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 588858001600 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 588858001601 Walker A/P-loop; other site 588858001602 ATP binding site [chemical binding]; other site 588858001603 Q-loop/lid; other site 588858001604 ABC transporter signature motif; other site 588858001605 Walker B; other site 588858001606 D-loop; other site 588858001607 H-loop/switch region; other site 588858001608 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 588858001609 Nitrogen regulatory protein P-II; Region: P-II; smart00938 588858001610 ammonium transporter; Provisional; Region: PRK10666 588858001611 acyl-CoA thioesterase II; Provisional; Region: PRK10526 588858001612 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 588858001613 active site 588858001614 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 588858001615 catalytic triad [active] 588858001616 dimer interface [polypeptide binding]; other site 588858001617 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 588858001618 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 588858001619 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 588858001620 DNA binding site [nucleotide binding] 588858001621 active site 588858001622 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 588858001623 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 588858001624 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 588858001625 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 588858001626 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 588858001627 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 588858001628 maltose O-acetyltransferase; Provisional; Region: PRK10092 588858001629 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 588858001630 active site 588858001631 substrate binding site [chemical binding]; other site 588858001632 trimer interface [polypeptide binding]; other site 588858001633 CoA binding site [chemical binding]; other site 588858001634 gene expression modulator; Provisional; Region: PRK10945 588858001635 Hha toxicity attenuator; Provisional; Region: PRK10667 588858001636 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 588858001637 Protein export membrane protein; Region: SecD_SecF; cl14618 588858001638 Protein export membrane protein; Region: SecD_SecF; cl14618 588858001639 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 588858001640 HlyD family secretion protein; Region: HlyD_3; pfam13437 588858001641 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 588858001642 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 588858001643 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 588858001644 hypothetical protein; Provisional; Region: PRK11281 588858001645 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 588858001646 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 588858001647 Mechanosensitive ion channel; Region: MS_channel; pfam00924 588858001648 Uncharacterized conserved protein [Function unknown]; Region: COG5464 588858001649 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 588858001650 hypothetical protein; Provisional; Region: PRK11038 588858001651 primosomal replication protein N''; Provisional; Region: PRK10093 588858001652 hypothetical protein; Provisional; Region: PRK10527 588858001653 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 588858001654 active site 588858001655 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 588858001656 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 588858001657 Walker A motif; other site 588858001658 ATP binding site [chemical binding]; other site 588858001659 Walker B motif; other site 588858001660 DNA polymerase III subunit delta'; Validated; Region: PRK08485 588858001661 arginine finger; other site 588858001662 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 588858001663 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 588858001664 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 588858001665 hypothetical protein; Validated; Region: PRK00153 588858001666 recombination protein RecR; Reviewed; Region: recR; PRK00076 588858001667 RecR protein; Region: RecR; pfam02132 588858001668 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 588858001669 putative active site [active] 588858001670 putative metal-binding site [ion binding]; other site 588858001671 tetramer interface [polypeptide binding]; other site 588858001672 heat shock protein 90; Provisional; Region: PRK05218 588858001673 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 588858001674 ATP binding site [chemical binding]; other site 588858001675 Mg2+ binding site [ion binding]; other site 588858001676 G-X-G motif; other site 588858001677 adenylate kinase; Reviewed; Region: adk; PRK00279 588858001678 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 588858001679 AMP-binding site [chemical binding]; other site 588858001680 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 588858001681 ferrochelatase; Reviewed; Region: hemH; PRK00035 588858001682 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 588858001683 C-terminal domain interface [polypeptide binding]; other site 588858001684 active site 588858001685 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 588858001686 active site 588858001687 N-terminal domain interface [polypeptide binding]; other site 588858001688 acetyl esterase; Provisional; Region: PRK10162 588858001689 inosine/guanosine kinase; Provisional; Region: PRK15074 588858001690 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 588858001691 putative cation:proton antiport protein; Provisional; Region: PRK10669 588858001692 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 588858001693 TrkA-N domain; Region: TrkA_N; pfam02254 588858001694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858001695 Major Facilitator Superfamily; Region: MFS_1; pfam07690 588858001696 putative substrate translocation pore; other site 588858001697 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 588858001698 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 588858001699 active site 588858001700 metal binding site [ion binding]; metal-binding site 588858001701 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 588858001702 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 588858001703 putative deacylase active site [active] 588858001704 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 588858001705 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 588858001706 copper exporting ATPase; Provisional; Region: copA; PRK10671 588858001707 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 588858001708 metal-binding site [ion binding] 588858001709 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 588858001710 metal-binding site [ion binding] 588858001711 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 588858001712 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 588858001713 motif II; other site 588858001714 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 588858001715 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 588858001716 DNA binding residues [nucleotide binding] 588858001717 dimer interface [polypeptide binding]; other site 588858001718 copper binding site [ion binding]; other site 588858001719 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 588858001720 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 588858001721 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 588858001722 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 588858001723 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 588858001724 Walker A/P-loop; other site 588858001725 ATP binding site [chemical binding]; other site 588858001726 Q-loop/lid; other site 588858001727 ABC transporter signature motif; other site 588858001728 Walker B; other site 588858001729 D-loop; other site 588858001730 H-loop/switch region; other site 588858001731 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 588858001732 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 588858001733 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 588858001734 oxidoreductase; Provisional; Region: PRK08017 588858001735 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 588858001736 NADP binding site [chemical binding]; other site 588858001737 active site 588858001738 steroid binding site; other site 588858001739 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 588858001740 active site 588858001741 catalytic triad [active] 588858001742 oxyanion hole [active] 588858001743 switch loop; other site 588858001744 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 588858001745 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 588858001746 Walker A/P-loop; other site 588858001747 ATP binding site [chemical binding]; other site 588858001748 Q-loop/lid; other site 588858001749 ABC transporter signature motif; other site 588858001750 Walker B; other site 588858001751 D-loop; other site 588858001752 H-loop/switch region; other site 588858001753 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 588858001754 FtsX-like permease family; Region: FtsX; pfam02687 588858001755 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 588858001756 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 588858001757 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 588858001758 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 588858001759 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 588858001760 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 588858001761 Walker A/P-loop; other site 588858001762 ATP binding site [chemical binding]; other site 588858001763 Q-loop/lid; other site 588858001764 ABC transporter signature motif; other site 588858001765 Walker B; other site 588858001766 D-loop; other site 588858001767 H-loop/switch region; other site 588858001768 NIL domain; Region: NIL; pfam09383 588858001769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858001770 dimer interface [polypeptide binding]; other site 588858001771 conserved gate region; other site 588858001772 ABC-ATPase subunit interface; other site 588858001773 Predicted ATPase [General function prediction only]; Region: COG2603 588858001774 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 588858001775 active site residue [active] 588858001776 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 588858001777 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858001778 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 588858001779 dimerization interface [polypeptide binding]; other site 588858001780 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 588858001781 ureidoglycolate hydrolase; Provisional; Region: PRK03606 588858001782 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 588858001783 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 588858001784 Bacterial transcriptional regulator; Region: IclR; pfam01614 588858001785 glyoxylate carboligase; Provisional; Region: PRK11269 588858001786 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 588858001787 PYR/PP interface [polypeptide binding]; other site 588858001788 dimer interface [polypeptide binding]; other site 588858001789 TPP binding site [chemical binding]; other site 588858001790 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 588858001791 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 588858001792 TPP-binding site [chemical binding]; other site 588858001793 hydroxypyruvate isomerase; Provisional; Region: PRK09997 588858001794 tartronate semialdehyde reductase; Provisional; Region: PRK15059 588858001795 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 588858001796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858001797 Major Facilitator Superfamily; Region: MFS_1; pfam07690 588858001798 putative substrate translocation pore; other site 588858001799 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 588858001800 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 588858001801 Na binding site [ion binding]; other site 588858001802 putative substrate binding site [chemical binding]; other site 588858001803 allantoinase; Provisional; Region: PRK08044 588858001804 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 588858001805 active site 588858001806 putative uracil/xanthine transporter; Provisional; Region: PRK11412 588858001807 glycerate kinase II; Provisional; Region: PRK09932 588858001808 Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257 588858001809 Mif2/CENP-C like; Region: Mif2; pfam11699 588858001810 Cupin domain; Region: Cupin_2; pfam07883 588858001811 allantoate amidohydrolase; Region: AllC; TIGR03176 588858001812 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 588858001813 active site 588858001814 metal binding site [ion binding]; metal-binding site 588858001815 dimer interface [polypeptide binding]; other site 588858001816 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 588858001817 membrane protein FdrA; Validated; Region: PRK06091 588858001818 CoA binding domain; Region: CoA_binding; pfam02629 588858001819 CoA-ligase; Region: Ligase_CoA; pfam00549 588858001820 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 588858001821 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 588858001822 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 588858001823 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 588858001824 putative substrate binding site [chemical binding]; other site 588858001825 nucleotide binding site [chemical binding]; other site 588858001826 nucleotide binding site [chemical binding]; other site 588858001827 homodimer interface [polypeptide binding]; other site 588858001828 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 588858001829 ATP-grasp domain; Region: ATP-grasp; pfam02222 588858001830 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 588858001831 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 588858001832 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 588858001833 putative active site [active] 588858001834 putative metal binding site [ion binding]; other site 588858001835 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 588858001836 substrate binding site [chemical binding]; other site 588858001837 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 588858001838 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 588858001839 active site 588858001840 HIGH motif; other site 588858001841 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 588858001842 KMSKS motif; other site 588858001843 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 588858001844 tRNA binding surface [nucleotide binding]; other site 588858001845 anticodon binding site; other site 588858001846 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4727 588858001847 Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916 588858001848 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 588858001849 ribosome-associated protein; Provisional; Region: PRK11507 588858001850 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 588858001851 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 588858001852 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 588858001853 homodimer interface [polypeptide binding]; other site 588858001854 NADP binding site [chemical binding]; other site 588858001855 substrate binding site [chemical binding]; other site 588858001856 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 588858001857 fimbrial protein FimI; Provisional; Region: PRK15200 588858001858 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 588858001859 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 588858001860 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 588858001861 outer membrane usher protein FimD; Provisional; Region: PRK15198 588858001862 PapC N-terminal domain; Region: PapC_N; pfam13954 588858001863 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 588858001864 PapC C-terminal domain; Region: PapC_C; pfam13953 588858001865 fimbrial-like adhesin; Provisional; Region: fimH; PRK15199 588858001866 fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934 588858001867 transcriptional regulator FimZ; Provisional; Region: PRK09935 588858001868 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 588858001869 active site 588858001870 phosphorylation site [posttranslational modification] 588858001871 intermolecular recognition site; other site 588858001872 dimerization interface [polypeptide binding]; other site 588858001873 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 588858001874 DNA binding residues [nucleotide binding] 588858001875 dimerization interface [polypeptide binding]; other site 588858001876 fimbriae regulatory protein FimW; Provisional; Region: PRK15201 588858001877 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 588858001878 DNA binding residues [nucleotide binding] 588858001879 dimerization interface [polypeptide binding]; other site 588858001880 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 588858001881 pseudogene; frameshift relative to Escherichia coli IS3 putative transposase (GB:AAC75150.1) 588858001882 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 588858001883 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 588858001884 Ligand binding site; other site 588858001885 Putative Catalytic site; other site 588858001886 DXD motif; other site 588858001887 Predicted membrane protein [Function unknown]; Region: COG2246 588858001888 GtrA-like protein; Region: GtrA; pfam04138 588858001889 pseudogene; in-frame stop following codon 56 588858001890 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 588858001891 ATP binding site [chemical binding]; other site 588858001892 Mg2+ binding site [ion binding]; other site 588858001893 G-X-G motif; other site 588858001894 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 588858001895 Cupin; Region: Cupin_6; pfam12852 588858001896 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 588858001897 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 588858001898 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 588858001899 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 588858001900 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 588858001901 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 588858001902 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 588858001903 Predicted membrane protein [Function unknown]; Region: COG3059 588858001904 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 588858001905 phenylalanine transporter; Provisional; Region: PRK10249 588858001906 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 588858001907 Mechanosensitive ion channel; Region: MS_channel; pfam00924 588858001908 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 588858001909 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 588858001910 active site 588858001911 oxyanion hole [active] 588858001912 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 588858001913 catalytic triad [active] 588858001914 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 588858001915 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 588858001916 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 588858001917 ATP binding site [chemical binding]; other site 588858001918 Walker B motif; other site 588858001919 arginine finger; other site 588858001920 Transcriptional antiterminator [Transcription]; Region: COG3933 588858001921 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 588858001922 active pocket/dimerization site; other site 588858001923 active site 588858001924 phosphorylation site [posttranslational modification] 588858001925 PRD domain; Region: PRD; pfam00874 588858001926 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 588858001927 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 588858001928 putative active site [active] 588858001929 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 588858001930 dimer interface [polypeptide binding]; other site 588858001931 active site 588858001932 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 588858001933 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 588858001934 dimer interface [polypeptide binding]; other site 588858001935 active site 588858001936 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 588858001937 dimer interface [polypeptide binding]; other site 588858001938 active site 588858001939 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 588858001940 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 588858001941 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 588858001942 active site 588858001943 phosphorylation site [posttranslational modification] 588858001944 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 588858001945 active pocket/dimerization site; other site 588858001946 active site 588858001947 phosphorylation site [posttranslational modification] 588858001948 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 588858001949 dimer interface [polypeptide binding]; other site 588858001950 FMN binding site [chemical binding]; other site 588858001951 hypothetical protein; Provisional; Region: PRK10250 588858001952 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 588858001953 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 588858001954 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 588858001955 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 588858001956 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 588858001957 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 588858001958 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 588858001959 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 588858001960 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 588858001961 outer membrane receptor FepA; Provisional; Region: PRK13524 588858001962 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 588858001963 N-terminal plug; other site 588858001964 ligand-binding site [chemical binding]; other site 588858001965 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 588858001966 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 588858001967 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 588858001968 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 588858001969 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 588858001970 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 588858001971 acyl-activating enzyme (AAE) consensus motif; other site 588858001972 AMP binding site [chemical binding]; other site 588858001973 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 588858001974 LPS O-antigen length regulator; Provisional; Region: PRK10381 588858001975 Chain length determinant protein; Region: Wzz; pfam02706 588858001976 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 588858001977 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 588858001978 Walker A/P-loop; other site 588858001979 ATP binding site [chemical binding]; other site 588858001980 Q-loop/lid; other site 588858001981 ABC transporter signature motif; other site 588858001982 Walker B; other site 588858001983 D-loop; other site 588858001984 H-loop/switch region; other site 588858001985 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 588858001986 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 588858001987 ABC-ATPase subunit interface; other site 588858001988 dimer interface [polypeptide binding]; other site 588858001989 putative PBP binding regions; other site 588858001990 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 588858001991 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 588858001992 ABC-ATPase subunit interface; other site 588858001993 dimer interface [polypeptide binding]; other site 588858001994 putative PBP binding regions; other site 588858001995 enterobactin exporter EntS; Provisional; Region: PRK10489 588858001996 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858001997 putative substrate translocation pore; other site 588858001998 ABC-type Fe2+-enterobactin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG4592 588858001999 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 588858002000 siderophore binding site; other site 588858002001 isochorismate synthase EntC; Provisional; Region: PRK15016 588858002002 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 588858002003 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 588858002004 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 588858002005 acyl-activating enzyme (AAE) consensus motif; other site 588858002006 active site 588858002007 AMP binding site [chemical binding]; other site 588858002008 substrate binding site [chemical binding]; other site 588858002009 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 588858002010 hydrophobic substrate binding pocket; other site 588858002011 Isochorismatase family; Region: Isochorismatase; pfam00857 588858002012 active site 588858002013 conserved cis-peptide bond; other site 588858002014 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 588858002015 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 588858002016 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 588858002017 putative NAD(P) binding site [chemical binding]; other site 588858002018 active site 588858002019 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 588858002020 CoenzymeA binding site [chemical binding]; other site 588858002021 subunit interaction site [polypeptide binding]; other site 588858002022 PHB binding site; other site 588858002023 carbon starvation protein A; Provisional; Region: PRK15015 588858002024 Carbon starvation protein CstA; Region: CstA; pfam02554 588858002025 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 588858002026 Uncharacterized small protein [Function unknown]; Region: COG2879 588858002027 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 588858002028 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 588858002029 putative active site [active] 588858002030 metal binding site [ion binding]; metal-binding site 588858002031 methionine aminotransferase; Validated; Region: PRK09082 588858002032 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 588858002033 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858002034 homodimer interface [polypeptide binding]; other site 588858002035 catalytic residue [active] 588858002036 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 588858002037 ParB-like nuclease domain; Region: ParBc; pfam02195 588858002038 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 588858002039 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 588858002040 Active Sites [active] 588858002041 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 588858002042 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 588858002043 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858002044 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 588858002045 dimerization interface [polypeptide binding]; other site 588858002046 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 588858002047 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 588858002048 dimerization domain [polypeptide binding]; other site 588858002049 dimer interface [polypeptide binding]; other site 588858002050 catalytic residues [active] 588858002051 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 588858002052 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 588858002053 dimer interface [polypeptide binding]; other site 588858002054 decamer (pentamer of dimers) interface [polypeptide binding]; other site 588858002055 catalytic triad [active] 588858002056 peroxidatic and resolving cysteines [active] 588858002057 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 588858002058 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 588858002059 catalytic residue [active] 588858002060 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 588858002061 catalytic residues [active] 588858002062 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 588858002063 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 588858002064 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 588858002065 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 588858002066 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 588858002067 putative [4Fe-4S] binding site [ion binding]; other site 588858002068 putative molybdopterin cofactor binding site [chemical binding]; other site 588858002069 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 588858002070 molybdopterin cofactor binding site; other site 588858002071 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 588858002072 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 588858002073 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 588858002074 Ligand Binding Site [chemical binding]; other site 588858002075 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 588858002076 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 588858002077 NAD binding site [chemical binding]; other site 588858002078 catalytic Zn binding site [ion binding]; other site 588858002079 structural Zn binding site [ion binding]; other site 588858002080 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 588858002081 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 588858002082 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 588858002083 B1 nucleotide binding pocket [chemical binding]; other site 588858002084 B2 nucleotide binding pocket [chemical binding]; other site 588858002085 CAS motifs; other site 588858002086 active site 588858002087 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 588858002088 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 588858002089 transmembrane helices; other site 588858002090 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 588858002091 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 588858002092 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 588858002093 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 588858002094 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 588858002095 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 588858002096 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 588858002097 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 588858002098 putative active site [active] 588858002099 (T/H)XGH motif; other site 588858002100 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 588858002101 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 588858002102 putative active site [active] 588858002103 heme pocket [chemical binding]; other site 588858002104 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 588858002105 ATP binding site [chemical binding]; other site 588858002106 Mg2+ binding site [ion binding]; other site 588858002107 G-X-G motif; other site 588858002108 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 588858002109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 588858002110 active site 588858002111 phosphorylation site [posttranslational modification] 588858002112 intermolecular recognition site; other site 588858002113 dimerization interface [polypeptide binding]; other site 588858002114 Transcriptional regulator; Region: CitT; pfam12431 588858002115 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 588858002116 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 588858002117 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 588858002118 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 588858002119 DNA-binding site [nucleotide binding]; DNA binding site 588858002120 RNA-binding motif; other site 588858002121 chromosome condensation membrane protein; Provisional; Region: PRK14196 588858002122 Predicted amidohydrolase [General function prediction only]; Region: COG0388 588858002123 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 588858002124 putative active site [active] 588858002125 catalytic triad [active] 588858002126 putative dimer interface [polypeptide binding]; other site 588858002127 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 588858002128 lipoyl synthase; Provisional; Region: PRK05481 588858002129 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 588858002130 FeS/SAM binding site; other site 588858002131 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 588858002132 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858002133 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 588858002134 substrate binding pocket [chemical binding]; other site 588858002135 dimerization interface [polypeptide binding]; other site 588858002136 lipoate-protein ligase B; Provisional; Region: PRK14342 588858002137 hypothetical protein; Provisional; Region: PRK04998 588858002138 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 588858002139 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 588858002140 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 588858002141 rare lipoprotein A; Provisional; Region: PRK10672 588858002142 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 588858002143 Sporulation related domain; Region: SPOR; pfam05036 588858002144 cell wall shape-determining protein; Provisional; Region: PRK10794 588858002145 penicillin-binding protein 2; Provisional; Region: PRK10795 588858002146 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 588858002147 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 588858002148 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 588858002149 ribosome-associated protein; Provisional; Region: PRK11538 588858002150 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 588858002151 catalytic core [active] 588858002152 threonine-phosphate decarboxylase; Provisional; Region: PRK08056 588858002153 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 588858002154 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858002155 homodimer interface [polypeptide binding]; other site 588858002156 catalytic residue [active] 588858002157 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 588858002158 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 588858002159 active site 588858002160 (T/H)XGH motif; other site 588858002161 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 588858002162 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 588858002163 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 588858002164 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 588858002165 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 588858002166 HIGH motif; other site 588858002167 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 588858002168 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 588858002169 active site 588858002170 KMSKS motif; other site 588858002171 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 588858002172 tRNA binding surface [nucleotide binding]; other site 588858002173 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 588858002174 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 588858002175 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 588858002176 Propionate catabolism activator; Region: PrpR_N; pfam06506 588858002177 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 588858002178 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 588858002179 Walker A motif; other site 588858002180 ATP binding site [chemical binding]; other site 588858002181 Walker B motif; other site 588858002182 arginine finger; other site 588858002183 hypothetical protein; Provisional; Region: PRK11032 588858002184 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 588858002185 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 588858002186 Sel1-like repeats; Region: SEL1; smart00671 588858002187 Sel1-like repeats; Region: SEL1; smart00671 588858002188 Sel1-like repeats; Region: SEL1; smart00671 588858002189 Sel1-like repeats; Region: SEL1; smart00671 588858002190 Sel1-like repeats; Region: SEL1; smart00671 588858002191 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 588858002192 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 588858002193 HSP70 interaction site [polypeptide binding]; other site 588858002194 similar to Escherichia coli putative tRNA ligase (AAC73749.1); disrupted by frameshift 588858002195 DnaJ domain; Region: DnaJ; pfam00226 588858002196 HSP70 interaction site [polypeptide binding]; other site 588858002197 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 588858002198 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 588858002199 nucleotide binding site [chemical binding]; other site 588858002200 putative NEF/HSP70 interaction site [polypeptide binding]; other site 588858002201 SBD interface [polypeptide binding]; other site 588858002202 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 588858002203 active site 588858002204 tetramer interface [polypeptide binding]; other site 588858002205 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 588858002206 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 588858002207 Walker A/P-loop; other site 588858002208 ATP binding site [chemical binding]; other site 588858002209 Q-loop/lid; other site 588858002210 ABC transporter signature motif; other site 588858002211 Walker B; other site 588858002212 D-loop; other site 588858002213 H-loop/switch region; other site 588858002214 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 588858002215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858002216 dimer interface [polypeptide binding]; other site 588858002217 conserved gate region; other site 588858002218 putative PBP binding loops; other site 588858002219 ABC-ATPase subunit interface; other site 588858002220 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 588858002221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858002222 dimer interface [polypeptide binding]; other site 588858002223 conserved gate region; other site 588858002224 putative PBP binding loops; other site 588858002225 ABC-ATPase subunit interface; other site 588858002226 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 588858002227 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 588858002228 substrate binding pocket [chemical binding]; other site 588858002229 membrane-bound complex binding site; other site 588858002230 hinge residues; other site 588858002231 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 588858002232 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 588858002233 putative active site [active] 588858002234 catalytic triad [active] 588858002235 putative dimer interface [polypeptide binding]; other site 588858002236 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 588858002237 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 588858002238 Transporter associated domain; Region: CorC_HlyC; smart01091 588858002239 metal-binding heat shock protein; Provisional; Region: PRK00016 588858002240 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 588858002241 PhoH-like protein; Region: PhoH; pfam02562 588858002242 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 588858002243 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 588858002244 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 588858002245 FeS/SAM binding site; other site 588858002246 TRAM domain; Region: TRAM; pfam01938 588858002247 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 588858002248 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 588858002249 asparagine synthetase B; Provisional; Region: asnB; PRK09431 588858002250 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 588858002251 active site 588858002252 dimer interface [polypeptide binding]; other site 588858002253 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 588858002254 Ligand Binding Site [chemical binding]; other site 588858002255 Molecular Tunnel; other site 588858002256 UMP phosphatase; Provisional; Region: PRK10444 588858002257 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 588858002258 active site 588858002259 motif I; other site 588858002260 motif II; other site 588858002261 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 588858002262 MarR family; Region: MarR; pfam01047 588858002263 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 588858002264 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 588858002265 nucleotide binding site [chemical binding]; other site 588858002266 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 588858002267 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 588858002268 active site 588858002269 dimer interface [polypeptide binding]; other site 588858002270 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 588858002271 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 588858002272 active site 588858002273 trimer interface [polypeptide binding]; other site 588858002274 allosteric site; other site 588858002275 active site lid [active] 588858002276 hexamer (dimer of trimers) interface [polypeptide binding]; other site 588858002277 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 588858002278 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 588858002279 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 588858002280 active site turn [active] 588858002281 phosphorylation site [posttranslational modification] 588858002282 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 588858002283 HPr interaction site; other site 588858002284 glycerol kinase (GK) interaction site [polypeptide binding]; other site 588858002285 active site 588858002286 phosphorylation site [posttranslational modification] 588858002287 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 588858002288 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 588858002289 active site 588858002290 HIGH motif; other site 588858002291 nucleotide binding site [chemical binding]; other site 588858002292 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 588858002293 KMSKS motif; other site 588858002294 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 588858002295 outer membrane porin, OprD family; Region: OprD; pfam03573 588858002296 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 588858002297 YbfN-like lipoprotein; Region: YbfN; pfam13982 588858002298 citrate-proton symporter; Provisional; Region: PRK15075 588858002299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858002300 putative substrate translocation pore; other site 588858002301 tricarballylate utilization protein B; Provisional; Region: PRK15033 588858002302 tricarballylate dehydrogenase; Validated; Region: PRK08274 588858002303 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 588858002304 Transcriptional regulator [Transcription]; Region: LysR; COG0583 588858002305 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858002306 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 588858002307 putative dimerization interface [polypeptide binding]; other site 588858002308 ferric uptake regulator; Provisional; Region: fur; PRK09462 588858002309 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 588858002310 metal binding site 2 [ion binding]; metal-binding site 588858002311 putative DNA binding helix; other site 588858002312 metal binding site 1 [ion binding]; metal-binding site 588858002313 dimer interface [polypeptide binding]; other site 588858002314 structural Zn2+ binding site [ion binding]; other site 588858002315 flavodoxin FldA; Validated; Region: PRK09267 588858002316 LexA regulated protein; Provisional; Region: PRK11675 588858002317 acyl-CoA esterase; Provisional; Region: PRK10673 588858002318 PGAP1-like protein; Region: PGAP1; pfam07819 588858002319 replication initiation regulator SeqA; Provisional; Region: PRK11187 588858002320 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 588858002321 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 588858002322 active site 588858002323 substrate binding site [chemical binding]; other site 588858002324 metal binding site [ion binding]; metal-binding site 588858002325 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 588858002326 putrescine transporter; Provisional; Region: potE; PRK10655 588858002327 ornithine decarboxylase; Provisional; Region: PRK13578 588858002328 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 588858002329 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 588858002330 homodimer interface [polypeptide binding]; other site 588858002331 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858002332 catalytic residue [active] 588858002333 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 588858002334 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 588858002335 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 588858002336 active site 588858002337 phosphorylation site [posttranslational modification] 588858002338 intermolecular recognition site; other site 588858002339 dimerization interface [polypeptide binding]; other site 588858002340 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 588858002341 DNA binding site [nucleotide binding] 588858002342 sensor protein KdpD; Provisional; Region: PRK10490 588858002343 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 588858002344 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 588858002345 Ligand Binding Site [chemical binding]; other site 588858002346 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 588858002347 GAF domain; Region: GAF_3; pfam13492 588858002348 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 588858002349 dimer interface [polypeptide binding]; other site 588858002350 phosphorylation site [posttranslational modification] 588858002351 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 588858002352 ATP binding site [chemical binding]; other site 588858002353 Mg2+ binding site [ion binding]; other site 588858002354 G-X-G motif; other site 588858002355 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 588858002356 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 588858002357 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 588858002358 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 588858002359 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 588858002360 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 588858002361 DNA photolyase; Region: DNA_photolyase; pfam00875 588858002362 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 588858002363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858002364 putative substrate translocation pore; other site 588858002365 POT family; Region: PTR2; pfam00854 588858002366 Uncharacterized conserved protein [Function unknown]; Region: COG0327 588858002367 metal-binding protein; Provisional; Region: PRK10799 588858002368 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 588858002369 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 588858002370 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 588858002371 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 588858002372 putative active site [active] 588858002373 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 588858002374 active site 588858002375 DNA binding site [nucleotide binding] 588858002376 Int/Topo IB signature motif; other site 588858002377 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 588858002378 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 588858002379 UDP-galactopyranose mutase; Region: GLF; pfam03275 588858002380 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 588858002381 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 588858002382 active site 588858002383 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 588858002384 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 588858002385 putative ADP-binding pocket [chemical binding]; other site 588858002386 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 588858002387 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 588858002388 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 588858002389 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 588858002390 Walker A/P-loop; other site 588858002391 ATP binding site [chemical binding]; other site 588858002392 Q-loop/lid; other site 588858002393 ABC transporter signature motif; other site 588858002394 Walker B; other site 588858002395 D-loop; other site 588858002396 H-loop/switch region; other site 588858002397 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 588858002398 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 588858002399 active site 588858002400 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 588858002401 active site 588858002402 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 588858002403 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 588858002404 endonuclease VIII; Provisional; Region: PRK10445 588858002405 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 588858002406 DNA binding site [nucleotide binding] 588858002407 catalytic residue [active] 588858002408 putative catalytic residues [active] 588858002409 H2TH interface [polypeptide binding]; other site 588858002410 intercalation triad [nucleotide binding]; other site 588858002411 substrate specificity determining residue; other site 588858002412 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 588858002413 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 588858002414 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 588858002415 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 588858002416 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 588858002417 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 588858002418 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 588858002419 dimer interface [polypeptide binding]; other site 588858002420 active site 588858002421 citrylCoA binding site [chemical binding]; other site 588858002422 NADH binding [chemical binding]; other site 588858002423 cationic pore residues; other site 588858002424 oxalacetate/citrate binding site [chemical binding]; other site 588858002425 coenzyme A binding site [chemical binding]; other site 588858002426 catalytic triad [active] 588858002427 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 588858002428 Iron-sulfur protein interface; other site 588858002429 proximal quinone binding site [chemical binding]; other site 588858002430 SdhD (CybS) interface [polypeptide binding]; other site 588858002431 proximal heme binding site [chemical binding]; other site 588858002432 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 588858002433 SdhC subunit interface [polypeptide binding]; other site 588858002434 proximal heme binding site [chemical binding]; other site 588858002435 cardiolipin binding site; other site 588858002436 Iron-sulfur protein interface; other site 588858002437 proximal quinone binding site [chemical binding]; other site 588858002438 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 588858002439 L-aspartate oxidase; Provisional; Region: PRK06175 588858002440 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 588858002441 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 588858002442 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 588858002443 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 588858002444 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 588858002445 TPP-binding site [chemical binding]; other site 588858002446 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 588858002447 dimer interface [polypeptide binding]; other site 588858002448 PYR/PP interface [polypeptide binding]; other site 588858002449 TPP binding site [chemical binding]; other site 588858002450 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 588858002451 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 588858002452 E3 interaction surface; other site 588858002453 lipoyl attachment site [posttranslational modification]; other site 588858002454 e3 binding domain; Region: E3_binding; pfam02817 588858002455 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 588858002456 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 588858002457 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 588858002458 CoA-ligase; Region: Ligase_CoA; pfam00549 588858002459 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 588858002460 CoA binding domain; Region: CoA_binding; smart00881 588858002461 CoA-ligase; Region: Ligase_CoA; pfam00549 588858002462 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 588858002463 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 588858002464 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 588858002465 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 588858002466 Predicted outer membrane lipoprotein [Function unknown]; Region: COG4890 588858002467 hypothetical protein; Provisional; Region: PRK10588 588858002468 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 588858002469 active site 588858002470 colicin uptake protein TolQ; Provisional; Region: PRK10801 588858002471 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 588858002472 colicin uptake protein TolR; Provisional; Region: PRK11024 588858002473 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 588858002474 TolA C-terminal; Region: TolA; pfam06519 588858002475 translocation protein TolB; Provisional; Region: tolB; PRK03629 588858002476 TolB amino-terminal domain; Region: TolB_N; pfam04052 588858002477 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 588858002478 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 588858002479 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 588858002480 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 588858002481 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 588858002482 ligand binding site [chemical binding]; other site 588858002483 tol-pal system protein YbgF; Provisional; Region: PRK10803 588858002484 Tetratricopeptide repeat; Region: TPR_6; pfam13174 588858002485 Tetratricopeptide repeat; Region: TPR_6; pfam13174 588858002486 quinolinate synthetase; Provisional; Region: PRK09375 588858002487 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 588858002488 zinc transporter ZitB; Provisional; Region: PRK03557 588858002489 YbgS-like protein; Region: YbgS; pfam13985 588858002490 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 588858002491 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 588858002492 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Region: FumA; COG1838 588858002493 fumarate hydratase; Provisional; Region: PRK06246 588858002494 Transcriptional regulator [Transcription]; Region: LysR; COG0583 588858002495 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858002496 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 588858002497 dimerization interface [polypeptide binding]; other site 588858002498 cell density-dependent motility repressor; Provisional; Region: PRK10082 588858002499 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858002500 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 588858002501 dimerization interface [polypeptide binding]; other site 588858002502 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 588858002503 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 588858002504 transmembrane helices; other site 588858002505 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 588858002506 pseudogene; frameshift relative to Klebsiella pneumoniae oxaloacetate decarboxylase alpha chain; OADA (SW:P13187) 588858002507 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 588858002508 Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767 588858002509 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 588858002510 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 588858002511 dimer interface [polypeptide binding]; other site 588858002512 putative PBP binding regions; other site 588858002513 ABC-ATPase subunit interface; other site 588858002514 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 588858002515 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 588858002516 Walker A/P-loop; other site 588858002517 ATP binding site [chemical binding]; other site 588858002518 Q-loop/lid; other site 588858002519 ABC transporter signature motif; other site 588858002520 Walker B; other site 588858002521 D-loop; other site 588858002522 H-loop/switch region; other site 588858002523 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 588858002524 catalytic core [active] 588858002525 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 588858002526 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 588858002527 active site 588858002528 catalytic residues [active] 588858002529 galactokinase; Provisional; Region: PRK05101 588858002530 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 588858002531 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 588858002532 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 588858002533 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 588858002534 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 588858002535 dimer interface [polypeptide binding]; other site 588858002536 active site 588858002537 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 588858002538 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 588858002539 NAD binding site [chemical binding]; other site 588858002540 homodimer interface [polypeptide binding]; other site 588858002541 active site 588858002542 substrate binding site [chemical binding]; other site 588858002543 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4714 588858002544 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 588858002545 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 588858002546 Walker A/P-loop; other site 588858002547 ATP binding site [chemical binding]; other site 588858002548 Q-loop/lid; other site 588858002549 ABC transporter signature motif; other site 588858002550 Walker B; other site 588858002551 D-loop; other site 588858002552 H-loop/switch region; other site 588858002553 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 588858002554 Walker A/P-loop; other site 588858002555 ATP binding site [chemical binding]; other site 588858002556 Q-loop/lid; other site 588858002557 ABC transporter signature motif; other site 588858002558 Walker B; other site 588858002559 D-loop; other site 588858002560 H-loop/switch region; other site 588858002561 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 588858002562 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 588858002563 molybdenum-pterin binding domain; Region: Mop; TIGR00638 588858002564 TOBE domain; Region: TOBE; pfam03459 588858002565 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 588858002566 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 588858002567 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 588858002568 substrate binding pocket [chemical binding]; other site 588858002569 membrane-bound complex binding site; other site 588858002570 hinge residues; other site 588858002571 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 588858002572 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858002573 dimer interface [polypeptide binding]; other site 588858002574 conserved gate region; other site 588858002575 putative PBP binding loops; other site 588858002576 ABC-ATPase subunit interface; other site 588858002577 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 588858002578 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 588858002579 Walker A/P-loop; other site 588858002580 ATP binding site [chemical binding]; other site 588858002581 Q-loop/lid; other site 588858002582 ABC transporter signature motif; other site 588858002583 Walker B; other site 588858002584 D-loop; other site 588858002585 H-loop/switch region; other site 588858002586 molybdenum-pterin binding domain; Region: Mop; TIGR00638 588858002587 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 588858002588 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 588858002589 active site 588858002590 motif I; other site 588858002591 motif II; other site 588858002592 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 588858002593 6-phosphogluconolactonase; Provisional; Region: PRK11028 588858002594 acyl-CoA thioesterase; Provisional; Region: PRK10531 588858002595 putative pectinesterase; Region: PLN02432; cl01911 588858002596 imidazolonepropionase; Validated; Region: PRK09356 588858002597 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 588858002598 active site 588858002599 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 588858002600 putative active site [active] 588858002601 putative metal binding site [ion binding]; other site 588858002602 histidine utilization repressor; Provisional; Region: PRK14999 588858002603 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 588858002604 DNA-binding site [nucleotide binding]; DNA binding site 588858002605 UTRA domain; Region: UTRA; pfam07702 588858002606 pseudogene; frameshift relative to Pseudomonas putida urocanate hydratase; HUTU (SW:P25080) 588858002607 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 588858002608 active sites [active] 588858002609 tetramer interface [polypeptide binding]; other site 588858002610 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 588858002611 substrate binding site [chemical binding]; other site 588858002612 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 588858002613 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 588858002614 inhibitor-cofactor binding pocket; inhibition site 588858002615 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858002616 catalytic residue [active] 588858002617 biotin synthase; Provisional; Region: PRK15108 588858002618 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 588858002619 FeS/SAM binding site; other site 588858002620 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 588858002621 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 588858002622 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 588858002623 substrate-cofactor binding pocket; other site 588858002624 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858002625 catalytic residue [active] 588858002626 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 588858002627 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 588858002628 S-adenosylmethionine binding site [chemical binding]; other site 588858002629 AAA domain; Region: AAA_26; pfam13500 588858002630 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 588858002631 excinuclease ABC subunit B; Provisional; Region: PRK05298 588858002632 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 588858002633 ATP binding site [chemical binding]; other site 588858002634 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 588858002635 nucleotide binding region [chemical binding]; other site 588858002636 ATP-binding site [chemical binding]; other site 588858002637 Ultra-violet resistance protein B; Region: UvrB; pfam12344 588858002638 UvrB/uvrC motif; Region: UVR; pfam02151 588858002639 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 588858002640 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 588858002641 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 588858002642 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 588858002643 Leucine-rich repeats; other site 588858002644 Substrate binding site [chemical binding]; other site 588858002645 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 588858002646 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 588858002647 putative substrate binding pocket [chemical binding]; other site 588858002648 dimer interface [polypeptide binding]; other site 588858002649 phosphate binding site [ion binding]; other site 588858002650 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 588858002651 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 588858002652 FeS/SAM binding site; other site 588858002653 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 588858002654 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 588858002655 MPT binding site; other site 588858002656 trimer interface [polypeptide binding]; other site 588858002657 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 588858002658 trimer interface [polypeptide binding]; other site 588858002659 dimer interface [polypeptide binding]; other site 588858002660 putative active site [active] 588858002661 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 588858002662 MoaE interaction surface [polypeptide binding]; other site 588858002663 MoeB interaction surface [polypeptide binding]; other site 588858002664 thiocarboxylated glycine; other site 588858002665 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 588858002666 MoaE homodimer interface [polypeptide binding]; other site 588858002667 MoaD interaction [polypeptide binding]; other site 588858002668 active site residues [active] 588858002669 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 588858002670 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 588858002671 Transposase IS200 like; Region: Y1_Tnp; pfam01797 588858002672 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 588858002673 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 588858002674 Predicted integral membrane protein [Function unknown]; Region: COG0392 588858002675 cardiolipin synthase 2; Provisional; Region: PRK11263 588858002676 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 588858002677 putative active site [active] 588858002678 catalytic site [active] 588858002679 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 588858002680 putative active site [active] 588858002681 catalytic site [active] 588858002682 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 588858002683 putative catalytic site [active] 588858002684 putative metal binding site [ion binding]; other site 588858002685 putative phosphate binding site [ion binding]; other site 588858002686 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 588858002687 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 588858002688 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 588858002689 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 588858002690 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 588858002691 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 588858002692 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 588858002693 Walker A/P-loop; other site 588858002694 ATP binding site [chemical binding]; other site 588858002695 Q-loop/lid; other site 588858002696 ABC transporter signature motif; other site 588858002697 Walker B; other site 588858002698 D-loop; other site 588858002699 H-loop/switch region; other site 588858002700 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 588858002701 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 588858002702 Walker A/P-loop; other site 588858002703 ATP binding site [chemical binding]; other site 588858002704 Q-loop/lid; other site 588858002705 ABC transporter signature motif; other site 588858002706 Walker B; other site 588858002707 D-loop; other site 588858002708 H-loop/switch region; other site 588858002709 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 588858002710 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 588858002711 HlyD family secretion protein; Region: HlyD_3; pfam13437 588858002712 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 588858002713 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 588858002714 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 588858002715 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 588858002716 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 588858002717 ATP binding site [chemical binding]; other site 588858002718 Mg++ binding site [ion binding]; other site 588858002719 motif III; other site 588858002720 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 588858002721 nucleotide binding region [chemical binding]; other site 588858002722 ATP-binding site [chemical binding]; other site 588858002723 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 588858002724 DEAD_2; Region: DEAD_2; pfam06733 588858002725 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 588858002726 glycosyl transferase family protein; Provisional; Region: PRK08136 588858002727 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 588858002728 hypothetical protein; Provisional; Region: PRK10259 588858002729 hypothetical protein; Provisional; Region: PRK11019 588858002730 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 588858002731 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 588858002732 putative mechanosensitive channel protein; Provisional; Region: PRK11465 588858002733 Mechanosensitive ion channel; Region: MS_channel; pfam00924 588858002734 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 588858002735 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 588858002736 Walker A/P-loop; other site 588858002737 ATP binding site [chemical binding]; other site 588858002738 Q-loop/lid; other site 588858002739 ABC transporter signature motif; other site 588858002740 Walker B; other site 588858002741 D-loop; other site 588858002742 H-loop/switch region; other site 588858002743 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 588858002744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858002745 dimer interface [polypeptide binding]; other site 588858002746 conserved gate region; other site 588858002747 putative PBP binding loops; other site 588858002748 ABC-ATPase subunit interface; other site 588858002749 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 588858002750 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 588858002751 substrate binding pocket [chemical binding]; other site 588858002752 membrane-bound complex binding site; other site 588858002753 hinge residues; other site 588858002754 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 588858002755 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 588858002756 dimerization interface [polypeptide binding]; other site 588858002757 DPS ferroxidase diiron center [ion binding]; other site 588858002758 ion pore; other site 588858002759 threonine and homoserine efflux system; Provisional; Region: PRK10532 588858002760 EamA-like transporter family; Region: EamA; pfam00892 588858002761 outer membrane protein X; Provisional; Region: ompX; PRK09408 588858002762 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 588858002763 Sulfatase; Region: Sulfatase; pfam00884 588858002764 manganese transport regulator MntR; Provisional; Region: PRK11050 588858002765 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 588858002766 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 588858002767 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 588858002768 transmembrane helices; other site 588858002769 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 588858002770 L,D-transpeptidase; Provisional; Region: PRK10260 588858002771 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 588858002772 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 588858002773 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 588858002774 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 588858002775 Walker A/P-loop; other site 588858002776 ATP binding site [chemical binding]; other site 588858002777 ABC transporter signature motif; other site 588858002778 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 588858002779 Walker B; other site 588858002780 ABC transporter; Region: ABC_tran_2; pfam12848 588858002781 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 588858002782 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 588858002783 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 588858002784 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 588858002785 motif II; other site 588858002786 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 588858002787 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 588858002788 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 588858002789 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 588858002790 active site 588858002791 motif I; other site 588858002792 motif II; other site 588858002793 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 588858002794 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 588858002795 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 588858002796 dimer interface [polypeptide binding]; other site 588858002797 active site 588858002798 glycine loop; other site 588858002799 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 588858002800 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 588858002801 FeS/SAM binding site; other site 588858002802 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 588858002803 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 588858002804 ATP binding site [chemical binding]; other site 588858002805 substrate interface [chemical binding]; other site 588858002806 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 588858002807 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 588858002808 dimer interface [polypeptide binding]; other site 588858002809 putative functional site; other site 588858002810 putative MPT binding site; other site 588858002811 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 588858002812 catalytic nucleophile [active] 588858002813 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 588858002814 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 588858002815 Walker A/P-loop; other site 588858002816 ATP binding site [chemical binding]; other site 588858002817 Q-loop/lid; other site 588858002818 ABC transporter signature motif; other site 588858002819 Walker B; other site 588858002820 D-loop; other site 588858002821 H-loop/switch region; other site 588858002822 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 588858002823 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 588858002824 Walker A/P-loop; other site 588858002825 ATP binding site [chemical binding]; other site 588858002826 Q-loop/lid; other site 588858002827 ABC transporter signature motif; other site 588858002828 Walker B; other site 588858002829 D-loop; other site 588858002830 H-loop/switch region; other site 588858002831 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 588858002832 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 588858002833 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 588858002834 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 588858002835 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858002836 dimer interface [polypeptide binding]; other site 588858002837 conserved gate region; other site 588858002838 putative PBP binding loops; other site 588858002839 ABC-ATPase subunit interface; other site 588858002840 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 588858002841 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 588858002842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858002843 dimer interface [polypeptide binding]; other site 588858002844 conserved gate region; other site 588858002845 putative PBP binding loops; other site 588858002846 ABC-ATPase subunit interface; other site 588858002847 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 588858002848 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 588858002849 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 588858002850 FeS/SAM binding site; other site 588858002851 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 588858002852 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 588858002853 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 588858002854 Ligand binding site [chemical binding]; other site 588858002855 Electron transfer flavoprotein domain; Region: ETF; pfam01012 588858002856 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 588858002857 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 588858002858 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 588858002859 similar to MaoC-like domain protein; disrupted by frameshift 588858002860 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 588858002861 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 588858002862 active site 588858002863 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 588858002864 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 588858002865 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 588858002866 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 588858002867 Transcriptional regulator [Transcription]; Region: LysR; COG0583 588858002868 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858002869 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 588858002870 putative dimerization interface [polypeptide binding]; other site 588858002871 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 588858002872 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 588858002873 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 588858002874 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 588858002875 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 588858002876 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 588858002877 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 588858002878 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 588858002879 putative C-terminal domain interface [polypeptide binding]; other site 588858002880 putative GSH binding site (G-site) [chemical binding]; other site 588858002881 putative dimer interface [polypeptide binding]; other site 588858002882 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 588858002883 putative N-terminal domain interface [polypeptide binding]; other site 588858002884 putative dimer interface [polypeptide binding]; other site 588858002885 putative substrate binding pocket (H-site) [chemical binding]; other site 588858002886 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 588858002887 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 588858002888 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 588858002889 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 588858002890 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 588858002891 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 588858002892 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 588858002893 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 588858002894 active site 588858002895 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 588858002896 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858002897 putative substrate translocation pore; other site 588858002898 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 588858002899 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 588858002900 active site 588858002901 motif I; other site 588858002902 motif II; other site 588858002903 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 588858002904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858002905 putative substrate translocation pore; other site 588858002906 Major Facilitator Superfamily; Region: MFS_1; pfam07690 588858002907 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 588858002908 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 588858002909 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 588858002910 putative transporter; Provisional; Region: PRK04972 588858002911 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 588858002912 TrkA-C domain; Region: TrkA_C; pfam02080 588858002913 TrkA-C domain; Region: TrkA_C; pfam02080 588858002914 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 588858002915 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 588858002916 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 588858002917 GSH binding site [chemical binding]; other site 588858002918 catalytic residues [active] 588858002919 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 588858002920 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 588858002921 dimer interface [polypeptide binding]; other site 588858002922 FMN binding site [chemical binding]; other site 588858002923 NADPH bind site [chemical binding]; other site 588858002924 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 588858002925 RimK-like ATP-grasp domain; Region: RimK; pfam08443 588858002926 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 588858002927 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 588858002928 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 588858002929 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 588858002930 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 588858002931 Walker A/P-loop; other site 588858002932 ATP binding site [chemical binding]; other site 588858002933 Q-loop/lid; other site 588858002934 ABC transporter signature motif; other site 588858002935 Walker B; other site 588858002936 D-loop; other site 588858002937 H-loop/switch region; other site 588858002938 TOBE domain; Region: TOBE_2; pfam08402 588858002939 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 588858002940 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858002941 dimer interface [polypeptide binding]; other site 588858002942 conserved gate region; other site 588858002943 putative PBP binding loops; other site 588858002944 ABC-ATPase subunit interface; other site 588858002945 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 588858002946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858002947 dimer interface [polypeptide binding]; other site 588858002948 conserved gate region; other site 588858002949 putative PBP binding loops; other site 588858002950 ABC-ATPase subunit interface; other site 588858002951 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 588858002952 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 588858002953 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 588858002954 S-adenosylmethionine binding site [chemical binding]; other site 588858002955 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 588858002956 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 588858002957 active site 588858002958 P-loop; other site 588858002959 phosphorylation site [posttranslational modification] 588858002960 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 588858002961 Sulfatase; Region: Sulfatase; cl17466 588858002962 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 588858002963 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 588858002964 substrate binding pocket [chemical binding]; other site 588858002965 membrane-bound complex binding site; other site 588858002966 hinge residues; other site 588858002967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858002968 dimer interface [polypeptide binding]; other site 588858002969 conserved gate region; other site 588858002970 putative PBP binding loops; other site 588858002971 ABC-ATPase subunit interface; other site 588858002972 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 588858002973 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858002974 dimer interface [polypeptide binding]; other site 588858002975 conserved gate region; other site 588858002976 putative PBP binding loops; other site 588858002977 ABC-ATPase subunit interface; other site 588858002978 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 588858002979 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 588858002980 substrate binding pocket [chemical binding]; other site 588858002981 membrane-bound complex binding site; other site 588858002982 hinge residues; other site 588858002983 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 588858002984 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 588858002985 Walker A/P-loop; other site 588858002986 ATP binding site [chemical binding]; other site 588858002987 Q-loop/lid; other site 588858002988 ABC transporter signature motif; other site 588858002989 Walker B; other site 588858002990 D-loop; other site 588858002991 H-loop/switch region; other site 588858002992 putative lipoprotein; Provisional; Region: PRK10533 588858002993 hypothetical protein; Provisional; Region: PRK02877 588858002994 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 588858002995 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 588858002996 amidase catalytic site [active] 588858002997 Zn binding residues [ion binding]; other site 588858002998 substrate binding site [chemical binding]; other site 588858002999 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 588858003000 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 588858003001 NAD(P) binding site [chemical binding]; other site 588858003002 active site 588858003003 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 588858003004 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 588858003005 putative NAD(P) binding site [chemical binding]; other site 588858003006 putative active site [active] 588858003007 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 588858003008 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 588858003009 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 588858003010 tetramer interface [polypeptide binding]; other site 588858003011 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858003012 catalytic residue [active] 588858003013 pyruvate dehydrogenase; Provisional; Region: PRK09124 588858003014 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 588858003015 PYR/PP interface [polypeptide binding]; other site 588858003016 dimer interface [polypeptide binding]; other site 588858003017 tetramer interface [polypeptide binding]; other site 588858003018 TPP binding site [chemical binding]; other site 588858003019 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 588858003020 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 588858003021 TPP-binding site [chemical binding]; other site 588858003022 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 588858003023 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 588858003024 FAD binding pocket [chemical binding]; other site 588858003025 FAD binding motif [chemical binding]; other site 588858003026 phosphate binding motif [ion binding]; other site 588858003027 beta-alpha-beta structure motif; other site 588858003028 NAD binding pocket [chemical binding]; other site 588858003029 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 588858003030 catalytic loop [active] 588858003031 iron binding site [ion binding]; other site 588858003032 hybrid cluster protein; Provisional; Region: PRK05290 588858003033 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 588858003034 ACS interaction site; other site 588858003035 CODH interaction site; other site 588858003036 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 588858003037 hybrid metal cluster; other site 588858003038 Predicted membrane protein [Function unknown]; Region: COG2431 588858003039 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 588858003040 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 588858003041 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 588858003042 putative active site [active] 588858003043 putative metal-binding site [ion binding]; other site 588858003044 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 588858003045 macrolide transporter subunit MacA; Provisional; Region: PRK11578 588858003046 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 588858003047 HlyD family secretion protein; Region: HlyD_3; pfam13437 588858003048 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 588858003049 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 588858003050 Walker A/P-loop; other site 588858003051 ATP binding site [chemical binding]; other site 588858003052 Q-loop/lid; other site 588858003053 ABC transporter signature motif; other site 588858003054 Walker B; other site 588858003055 D-loop; other site 588858003056 H-loop/switch region; other site 588858003057 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 588858003058 FtsX-like permease family; Region: FtsX; pfam02687 588858003059 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 588858003060 DNA-binding site [nucleotide binding]; DNA binding site 588858003061 RNA-binding motif; other site 588858003062 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 588858003063 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 588858003064 Clp amino terminal domain; Region: Clp_N; pfam02861 588858003065 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 588858003066 Walker A motif; other site 588858003067 ATP binding site [chemical binding]; other site 588858003068 Walker B motif; other site 588858003069 arginine finger; other site 588858003070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 588858003071 Walker A motif; other site 588858003072 ATP binding site [chemical binding]; other site 588858003073 Walker B motif; other site 588858003074 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 588858003075 Transposase IS200 like; Region: Y1_Tnp; pfam01797 588858003076 Integrase core domain; Region: rve; pfam00665 588858003077 Integrase core domain; Region: rve_3; pfam13683 588858003078 Helix-turn-helix domain; Region: HTH_28; pfam13518 588858003079 Isochorismatase family; Region: Isochorismatase; pfam00857 588858003080 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 588858003081 catalytic triad [active] 588858003082 dimer interface [polypeptide binding]; other site 588858003083 conserved cis-peptide bond; other site 588858003084 Pirin-related protein [General function prediction only]; Region: COG1741 588858003085 Pirin; Region: Pirin; pfam02678 588858003086 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 588858003087 LysR family transcriptional regulator; Provisional; Region: PRK14997 588858003088 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858003089 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 588858003090 putative effector binding pocket; other site 588858003091 putative dimerization interface [polypeptide binding]; other site 588858003092 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 588858003093 rRNA binding site [nucleotide binding]; other site 588858003094 predicted 30S ribosome binding site; other site 588858003095 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 588858003096 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 588858003097 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 588858003098 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 588858003099 Walker A/P-loop; other site 588858003100 ATP binding site [chemical binding]; other site 588858003101 Q-loop/lid; other site 588858003102 ABC transporter signature motif; other site 588858003103 Walker B; other site 588858003104 D-loop; other site 588858003105 H-loop/switch region; other site 588858003106 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 588858003107 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 588858003108 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 588858003109 Walker A/P-loop; other site 588858003110 ATP binding site [chemical binding]; other site 588858003111 Q-loop/lid; other site 588858003112 ABC transporter signature motif; other site 588858003113 Walker B; other site 588858003114 D-loop; other site 588858003115 H-loop/switch region; other site 588858003116 thioredoxin reductase; Provisional; Region: PRK10262 588858003117 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 588858003118 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 588858003119 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 588858003120 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 588858003121 putative DNA binding site [nucleotide binding]; other site 588858003122 putative Zn2+ binding site [ion binding]; other site 588858003123 AsnC family; Region: AsnC_trans_reg; pfam01037 588858003124 DNA translocase FtsK; Provisional; Region: PRK10263 588858003125 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 588858003126 DNA translocase FtsK; Provisional; Region: PRK10263 588858003127 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 588858003128 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 588858003129 periplasmic chaperone LolA; Region: lolA; TIGR00547 588858003130 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 588858003131 recombination factor protein RarA; Reviewed; Region: PRK13342 588858003132 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 588858003133 Walker A motif; other site 588858003134 ATP binding site [chemical binding]; other site 588858003135 Walker B motif; other site 588858003136 arginine finger; other site 588858003137 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 588858003138 seryl-tRNA synthetase; Provisional; Region: PRK05431 588858003139 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 588858003140 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 588858003141 dimer interface [polypeptide binding]; other site 588858003142 active site 588858003143 motif 1; other site 588858003144 motif 2; other site 588858003145 motif 3; other site 588858003146 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 588858003147 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 588858003148 putative [Fe4-S4] binding site [ion binding]; other site 588858003149 putative molybdopterin cofactor binding site [chemical binding]; other site 588858003150 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 588858003151 putative molybdopterin cofactor binding site; other site 588858003152 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 588858003153 4Fe-4S binding domain; Region: Fer4; pfam00037 588858003154 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 588858003155 putative MFS family transporter protein; Provisional; Region: PRK03633 588858003156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858003157 putative substrate translocation pore; other site 588858003158 inner membrane transporter YjeM; Provisional; Region: PRK15238 588858003159 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 588858003160 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 588858003161 FeS/SAM binding site; other site 588858003162 pathogenicity island 1 protein SopD2; Provisional; Region: PRK15380 588858003163 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 588858003164 Pyruvate formate lyase 1; Region: PFL1; cd01678 588858003165 coenzyme A binding site [chemical binding]; other site 588858003166 active site 588858003167 catalytic residues [active] 588858003168 glycine loop; other site 588858003169 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 588858003170 uncharacterized domain; Region: TIGR00702 588858003171 YcaO-like family; Region: YcaO; pfam02624 588858003172 Predicted membrane protein [Function unknown]; Region: COG2323 588858003173 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 588858003174 homodimer interface [polypeptide binding]; other site 588858003175 substrate-cofactor binding pocket; other site 588858003176 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858003177 catalytic residue [active] 588858003178 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 588858003179 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 588858003180 hinge; other site 588858003181 active site 588858003182 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 588858003183 cytidylate kinase; Provisional; Region: cmk; PRK00023 588858003184 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 588858003185 CMP-binding site; other site 588858003186 The sites determining sugar specificity; other site 588858003187 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 588858003188 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 588858003189 RNA binding site [nucleotide binding]; other site 588858003190 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 588858003191 RNA binding site [nucleotide binding]; other site 588858003192 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 588858003193 RNA binding site [nucleotide binding]; other site 588858003194 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 588858003195 RNA binding site [nucleotide binding]; other site 588858003196 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 588858003197 RNA binding site [nucleotide binding]; other site 588858003198 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 588858003199 IHF dimer interface [polypeptide binding]; other site 588858003200 IHF - DNA interface [nucleotide binding]; other site 588858003201 ComEC family competence protein; Provisional; Region: PRK11539 588858003202 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 588858003203 Competence protein; Region: Competence; pfam03772 588858003204 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 588858003205 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 588858003206 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 588858003207 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 588858003208 Walker A/P-loop; other site 588858003209 ATP binding site [chemical binding]; other site 588858003210 Q-loop/lid; other site 588858003211 ABC transporter signature motif; other site 588858003212 Walker B; other site 588858003213 D-loop; other site 588858003214 H-loop/switch region; other site 588858003215 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 588858003216 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 588858003217 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 588858003218 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 588858003219 hypothetical protein; Provisional; Region: PRK11827 588858003220 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 588858003221 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 588858003222 Ligand binding site; other site 588858003223 oligomer interface; other site 588858003224 hypothetical protein; Provisional; Region: PRK10593 588858003225 Uncharacterized conserved protein [Function unknown]; Region: COG1434 588858003226 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 588858003227 putative active site [active] 588858003228 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 588858003229 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 588858003230 S-adenosylmethionine binding site [chemical binding]; other site 588858003231 condesin subunit F; Provisional; Region: PRK05260 588858003232 condesin subunit E; Provisional; Region: PRK05256 588858003233 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 588858003234 P-loop containing region of AAA domain; Region: AAA_29; cl17516 588858003235 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 588858003236 murein L,D-transpeptidase; Provisional; Region: PRK10594 588858003237 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 588858003238 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 588858003239 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 588858003240 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 588858003241 Peptidase M15; Region: Peptidase_M15_3; cl01194 588858003242 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 588858003243 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 588858003244 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 588858003245 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858003246 homodimer interface [polypeptide binding]; other site 588858003247 catalytic residue [active] 588858003248 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 588858003249 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 588858003250 trimer interface [polypeptide binding]; other site 588858003251 eyelet of channel; other site 588858003252 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 588858003253 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 588858003254 putative dimer interface [polypeptide binding]; other site 588858003255 putative anticodon binding site; other site 588858003256 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 588858003257 homodimer interface [polypeptide binding]; other site 588858003258 motif 1; other site 588858003259 motif 2; other site 588858003260 active site 588858003261 motif 3; other site 588858003262 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 588858003263 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 588858003264 putative DNA binding site [nucleotide binding]; other site 588858003265 putative Zn2+ binding site [ion binding]; other site 588858003266 AsnC family; Region: AsnC_trans_reg; pfam01037 588858003267 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 588858003268 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 588858003269 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 588858003270 catalytic residue [active] 588858003271 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 588858003272 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 588858003273 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 588858003274 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 588858003275 active site 588858003276 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 588858003277 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 588858003278 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 588858003279 Int/Topo IB signature motif; other site 588858003280 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 588858003281 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 588858003282 RecT family; Region: RecT; pfam03837 588858003283 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 588858003284 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 588858003285 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 588858003286 non-specific DNA binding site [nucleotide binding]; other site 588858003287 salt bridge; other site 588858003288 sequence-specific DNA binding site [nucleotide binding]; other site 588858003289 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 588858003290 DNA binding residues [nucleotide binding] 588858003291 Bacteriophage CII protein; Region: Phage_CII; pfam05269 588858003292 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 588858003293 primosomal protein DnaI; Provisional; Region: PRK02854 588858003294 putative replication protein; Provisional; Region: PRK12377 588858003295 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 588858003296 Walker A motif; other site 588858003297 ATP binding site [chemical binding]; other site 588858003298 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 588858003299 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 588858003300 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 588858003301 DinI-like family; Region: DinI; pfam06183 588858003302 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 588858003303 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 588858003304 Antitermination protein; Region: Antiterm; pfam03589 588858003305 Antitermination protein; Region: Antiterm; pfam03589 588858003306 PipA protein; Region: PipA; pfam07108 588858003307 phage holin, lambda family; Region: holin_lambda; TIGR01594 588858003308 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 588858003309 catalytic residues [active] 588858003310 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 588858003311 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 588858003312 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 588858003313 Domain of unknown function (DUF1859); Region: DUF1859; pfam08948 588858003314 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 588858003315 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 588858003316 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 588858003317 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 588858003318 oligomer interface [polypeptide binding]; other site 588858003319 active site residues [active] 588858003320 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 588858003321 Uncharacterized conserved protein [Function unknown]; Region: COG5471 588858003322 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 588858003323 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 588858003324 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 588858003325 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 588858003326 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 588858003327 phage tail assembly protein T; Region: phage_lam_T; TIGR01715 588858003328 Phage-related minor tail protein [Function unknown]; Region: COG5281 588858003329 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 588858003330 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 588858003331 Phage-related protein [Function unknown]; Region: COG4718 588858003332 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 588858003333 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 588858003334 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 588858003335 E-class dimer interface [polypeptide binding]; other site 588858003336 P-class dimer interface [polypeptide binding]; other site 588858003337 active site 588858003338 Cu2+ binding site [ion binding]; other site 588858003339 Zn2+ binding site [ion binding]; other site 588858003340 Phage-related protein [Function unknown]; Region: gp18; COG4672 588858003341 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 588858003342 MPN+ (JAMM) motif; other site 588858003343 Zinc-binding site [ion binding]; other site 588858003344 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 588858003345 NlpC/P60 family; Region: NLPC_P60; cl17555 588858003346 Phage-related protein, tail component [Function unknown]; Region: COG4723 588858003347 Phage-related protein, tail component [Function unknown]; Region: COG4733 588858003348 Putative phage tail protein; Region: Phage-tail_3; pfam13550 588858003349 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 588858003350 Interdomain contacts; other site 588858003351 Cytokine receptor motif; other site 588858003352 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 588858003353 Fibronectin type III protein; Region: DUF3672; pfam12421 588858003354 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 588858003355 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 588858003356 Phage Tail Collar Domain; Region: Collar; pfam07484 588858003357 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 588858003358 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 588858003359 pseudogene; in-frame stop following codon 112 588858003360 hypothetical protein; Provisional; Region: PRK09951 588858003361 DinI-like family; Region: DinI; cl11630 588858003362 aminopeptidase N; Provisional; Region: pepN; PRK14015 588858003363 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 588858003364 active site 588858003365 Zn binding site [ion binding]; other site 588858003366 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 588858003367 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 588858003368 quinone interaction residues [chemical binding]; other site 588858003369 active site 588858003370 catalytic residues [active] 588858003371 FMN binding site [chemical binding]; other site 588858003372 substrate binding site [chemical binding]; other site 588858003373 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 588858003374 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 588858003375 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 588858003376 MOSC domain; Region: MOSC; pfam03473 588858003377 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 588858003378 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 588858003379 catalytic loop [active] 588858003380 iron binding site [ion binding]; other site 588858003381 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 588858003382 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 588858003383 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 588858003384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 588858003385 S-adenosylmethionine binding site [chemical binding]; other site 588858003386 ABC transporter ATPase component; Reviewed; Region: PRK11147 588858003387 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 588858003388 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 588858003389 Walker A/P-loop; other site 588858003390 Walker A/P-loop; other site 588858003391 ATP binding site [chemical binding]; other site 588858003392 ATP binding site [chemical binding]; other site 588858003393 Q-loop/lid; other site 588858003394 Q-loop/lid; other site 588858003395 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 588858003396 ABC transporter signature motif; other site 588858003397 Walker B; other site 588858003398 D-loop; other site 588858003399 ABC transporter; Region: ABC_tran_2; pfam12848 588858003400 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 588858003401 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 588858003402 Paraquat-inducible protein A; Region: PqiA; pfam04403 588858003403 Paraquat-inducible protein A; Region: PqiA; pfam04403 588858003404 paraquat-inducible protein B; Provisional; Region: PRK10807 588858003405 mce related protein; Region: MCE; pfam02470 588858003406 mce related protein; Region: MCE; pfam02470 588858003407 mce related protein; Region: MCE; pfam02470 588858003408 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 588858003409 Protein of unknown function (DUF330); Region: DUF330; pfam03886 588858003410 ribosome modulation factor; Provisional; Region: PRK14563 588858003411 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 588858003412 active site 1 [active] 588858003413 dimer interface [polypeptide binding]; other site 588858003414 active site 2 [active] 588858003415 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 588858003416 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 588858003417 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 588858003418 outer membrane protein A; Reviewed; Region: PRK10808 588858003419 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 588858003420 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 588858003421 ligand binding site [chemical binding]; other site 588858003422 cell division inhibitor SulA; Region: sula; TIGR00623 588858003423 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 588858003424 TfoX C-terminal domain; Region: TfoX_C; pfam04994 588858003425 TIGR01666 family membrane protein; Region: YCCS 588858003426 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 588858003427 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 588858003428 Predicted membrane protein [Function unknown]; Region: COG3304 588858003429 Domain of unknown function (DUF307); Region: DUF307; pfam03733 588858003430 Domain of unknown function (DUF307); Region: DUF307; pfam03733 588858003431 DNA helicase IV; Provisional; Region: helD; PRK11054 588858003432 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 588858003433 Part of AAA domain; Region: AAA_19; pfam13245 588858003434 Family description; Region: UvrD_C_2; pfam13538 588858003435 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 588858003436 active site 588858003437 dimer interfaces [polypeptide binding]; other site 588858003438 catalytic residues [active] 588858003439 hypothetical protein; Provisional; Region: PRK03641 588858003440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 588858003441 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 588858003442 heat shock protein HspQ; Provisional; Region: PRK14129 588858003443 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 588858003444 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 588858003445 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 588858003446 putative RNA binding site [nucleotide binding]; other site 588858003447 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 588858003448 S-adenosylmethionine binding site [chemical binding]; other site 588858003449 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 588858003450 substrate binding site [chemical binding]; other site 588858003451 Cupin domain; Region: Cupin_2; cl17218 588858003452 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 588858003453 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 588858003454 acylphosphatase; Provisional; Region: PRK14426 588858003455 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 588858003456 sulfur transfer protein TusE; Provisional; Region: PRK11508 588858003457 YccA-like proteins; Region: YccA_like; cd10433 588858003458 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 588858003459 PipA protein; Region: PipA; pfam07108 588858003460 secreted effector protein PipB; Provisional; Region: PRK15197 588858003461 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 588858003462 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 588858003463 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 588858003464 type III secretion chaperone protein SigE; Provisional; Region: PRK15202 588858003465 inositol phosphate phosphatase SopB; Provisional; Region: PRK15378 588858003466 Enterobacterial virulence protein IpgD; Region: IpgD; pfam05925 588858003467 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 588858003468 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 588858003469 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 588858003470 HAMP domain; Region: HAMP; pfam00672 588858003471 dimerization interface [polypeptide binding]; other site 588858003472 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 588858003473 dimer interface [polypeptide binding]; other site 588858003474 phosphorylation site [posttranslational modification] 588858003475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 588858003476 ATP binding site [chemical binding]; other site 588858003477 Mg2+ binding site [ion binding]; other site 588858003478 G-X-G motif; other site 588858003479 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 588858003480 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 588858003481 active site 588858003482 phosphorylation site [posttranslational modification] 588858003483 intermolecular recognition site; other site 588858003484 dimerization interface [polypeptide binding]; other site 588858003485 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 588858003486 DNA binding site [nucleotide binding] 588858003487 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 588858003488 active site 588858003489 homotetramer interface [polypeptide binding]; other site 588858003490 4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486 588858003491 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 588858003492 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 588858003493 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 588858003494 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 588858003495 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203 588858003496 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 588858003497 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 588858003498 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 588858003499 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 588858003500 NAD binding site [chemical binding]; other site 588858003501 catalytic residues [active] 588858003502 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 588858003503 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 588858003504 putative active site [active] 588858003505 putative metal binding site [ion binding]; other site 588858003506 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 588858003507 putative substrate binding pocket [chemical binding]; other site 588858003508 trimer interface [polypeptide binding]; other site 588858003509 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 588858003510 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 588858003511 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858003512 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 588858003513 putative substrate translocation pore; other site 588858003514 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 588858003515 Cupin domain; Region: Cupin_2; pfam07883 588858003516 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 588858003517 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 588858003518 anti-adapter protein IraM; Provisional; Region: PRK09919 588858003519 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 588858003520 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 588858003521 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 588858003522 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 588858003523 HSP70 interaction site [polypeptide binding]; other site 588858003524 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 588858003525 substrate binding site [polypeptide binding]; other site 588858003526 dimer interface [polypeptide binding]; other site 588858003527 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 588858003528 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 588858003529 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 588858003530 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 588858003531 DsbD alpha interface [polypeptide binding]; other site 588858003532 catalytic residues [active] 588858003533 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 588858003534 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 588858003535 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 588858003536 catalytic residues [active] 588858003537 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 588858003538 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 588858003539 catalytic residues [active] 588858003540 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 588858003541 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 588858003542 catalytic core [active] 588858003543 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 588858003544 hypothetical protein; Provisional; Region: PRK10174 588858003545 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 588858003546 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 588858003547 pseudogene; in-frame stops following codons 5 and 21 588858003548 General stress protein [General function prediction only]; Region: GsiB; COG3729 588858003549 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 588858003550 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 588858003551 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 588858003552 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 588858003553 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 588858003554 Predicted transcriptional regulator [Transcription]; Region: COG3905 588858003555 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 588858003556 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 588858003557 Glutamate binding site [chemical binding]; other site 588858003558 NAD binding site [chemical binding]; other site 588858003559 catalytic residues [active] 588858003560 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 588858003561 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 588858003562 Na binding site [ion binding]; other site 588858003563 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 588858003564 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 588858003565 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 588858003566 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 588858003567 putative active site [active] 588858003568 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 588858003569 Na binding site [ion binding]; other site 588858003570 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 588858003571 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 588858003572 putative active site cavity [active] 588858003573 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 588858003574 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 588858003575 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178 588858003576 putative sialic acid transporter; Provisional; Region: PRK12307 588858003577 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858003578 putative substrate translocation pore; other site 588858003579 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 588858003580 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 588858003581 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 588858003582 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 588858003583 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 588858003584 putative ligand binding site [chemical binding]; other site 588858003585 NAD binding site [chemical binding]; other site 588858003586 dimerization interface [polypeptide binding]; other site 588858003587 catalytic site [active] 588858003588 putative hydrolase; Validated; Region: PRK09248 588858003589 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 588858003590 active site 588858003591 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 588858003592 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 588858003593 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 588858003594 curli assembly protein CsgF; Provisional; Region: PRK10050 588858003595 curli assembly protein CsgE; Provisional; Region: PRK10386 588858003596 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 588858003597 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 588858003598 DNA binding residues [nucleotide binding] 588858003599 dimerization interface [polypeptide binding]; other site 588858003600 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 588858003601 Curlin associated repeat; Region: Curlin_rpt; pfam07012 588858003602 Curlin associated repeat; Region: Curlin_rpt; pfam07012 588858003603 major curlin subunit; Provisional; Region: csgA; PRK10051 588858003604 Curlin associated repeat; Region: Curlin_rpt; pfam07012 588858003605 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 588858003606 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 588858003607 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 588858003608 putative ADP-ribose binding site [chemical binding]; other site 588858003609 putative active site [active] 588858003610 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 588858003611 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 588858003612 putative active site [active] 588858003613 catalytic site [active] 588858003614 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 588858003615 putative active site [active] 588858003616 catalytic site [active] 588858003617 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 588858003618 Acyltransferase family; Region: Acyl_transf_3; pfam01757 588858003619 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 588858003620 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 588858003621 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 588858003622 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 588858003623 Ligand binding site; other site 588858003624 DXD motif; other site 588858003625 lipoprotein; Provisional; Region: PRK10175 588858003626 secY/secA suppressor protein; Provisional; Region: PRK11467 588858003627 drug efflux system protein MdtG; Provisional; Region: PRK09874 588858003628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858003629 putative substrate translocation pore; other site 588858003630 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 588858003631 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 588858003632 putative acyl-acceptor binding pocket; other site 588858003633 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 588858003634 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 588858003635 active site residue [active] 588858003636 hypothetical protein; Provisional; Region: PRK03757 588858003637 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 588858003638 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 588858003639 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 588858003640 hydroxyglutarate oxidase; Provisional; Region: PRK11728 588858003641 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 588858003642 DNA damage-inducible protein I; Provisional; Region: PRK10597 588858003643 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 588858003644 active site 588858003645 substrate binding pocket [chemical binding]; other site 588858003646 dimer interface [polypeptide binding]; other site 588858003647 lipoprotein; Provisional; Region: PRK10598 588858003648 glutaredoxin 2; Provisional; Region: PRK10387 588858003649 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 588858003650 C-terminal domain interface [polypeptide binding]; other site 588858003651 GSH binding site (G-site) [chemical binding]; other site 588858003652 catalytic residues [active] 588858003653 putative dimer interface [polypeptide binding]; other site 588858003654 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 588858003655 N-terminal domain interface [polypeptide binding]; other site 588858003656 multidrug resistance protein MdtH; Provisional; Region: PRK11646 588858003657 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858003658 putative substrate translocation pore; other site 588858003659 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 588858003660 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 588858003661 hypothetical protein; Provisional; Region: PRK11239 588858003662 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 588858003663 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 588858003664 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 588858003665 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 588858003666 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 588858003667 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 588858003668 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 588858003669 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 588858003670 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 588858003671 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 588858003672 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 588858003673 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 588858003674 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 588858003675 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 588858003676 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 588858003677 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 588858003678 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 588858003679 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 588858003680 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 588858003681 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 588858003682 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 588858003683 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 588858003684 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 588858003685 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 588858003686 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 588858003687 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 588858003688 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 588858003689 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 588858003690 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 588858003691 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 588858003692 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 588858003693 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 588858003694 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 588858003695 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 588858003696 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 588858003697 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 588858003698 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 588858003699 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 588858003700 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 588858003701 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 588858003702 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 588858003703 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 588858003704 homodimer interface [polypeptide binding]; other site 588858003705 oligonucleotide binding site [chemical binding]; other site 588858003706 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 588858003707 pseudogene; in-frame stop following codon 97; no start near Escherichia coli start 588858003708 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 588858003709 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 588858003710 RNA binding surface [nucleotide binding]; other site 588858003711 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 588858003712 active site 588858003713 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 588858003714 Maf-like protein; Region: Maf; pfam02545 588858003715 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 588858003716 active site 588858003717 dimer interface [polypeptide binding]; other site 588858003718 hypothetical protein; Provisional; Region: PRK11193 588858003719 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 588858003720 putative phosphate acyltransferase; Provisional; Region: PRK05331 588858003721 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 588858003722 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 588858003723 dimer interface [polypeptide binding]; other site 588858003724 active site 588858003725 CoA binding pocket [chemical binding]; other site 588858003726 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 588858003727 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 588858003728 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 588858003729 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 588858003730 NAD(P) binding site [chemical binding]; other site 588858003731 homotetramer interface [polypeptide binding]; other site 588858003732 homodimer interface [polypeptide binding]; other site 588858003733 active site 588858003734 acyl carrier protein; Provisional; Region: acpP; PRK00982 588858003735 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 588858003736 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 588858003737 dimer interface [polypeptide binding]; other site 588858003738 active site 588858003739 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 588858003740 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 588858003741 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858003742 catalytic residue [active] 588858003743 conserved hypothetical protein, YceG family; Region: TIGR00247 588858003744 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 588858003745 dimerization interface [polypeptide binding]; other site 588858003746 thymidylate kinase; Validated; Region: tmk; PRK00698 588858003747 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 588858003748 TMP-binding site; other site 588858003749 ATP-binding site [chemical binding]; other site 588858003750 DNA polymerase III subunit delta'; Validated; Region: PRK07993 588858003751 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 588858003752 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 588858003753 active site 588858003754 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 588858003755 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 588858003756 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 588858003757 active site turn [active] 588858003758 phosphorylation site [posttranslational modification] 588858003759 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 588858003760 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 588858003761 N-terminal plug; other site 588858003762 ligand-binding site [chemical binding]; other site 588858003763 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 588858003764 nucleotide binding site/active site [active] 588858003765 HIT family signature motif; other site 588858003766 catalytic residue [active] 588858003767 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 588858003768 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 588858003769 putative dimer interface [polypeptide binding]; other site 588858003770 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 588858003771 thiamine kinase; Region: ycfN_thiK; TIGR02721 588858003772 thiamine kinase; Provisional; Region: thiK; PRK10271 588858003773 substrate binding site [chemical binding]; other site 588858003774 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 588858003775 beta-hexosaminidase; Provisional; Region: PRK05337 588858003776 hypothetical protein; Provisional; Region: PRK04940 588858003777 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 588858003778 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 588858003779 hypothetical protein; Provisional; Region: PRK11280 588858003780 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 588858003781 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 588858003782 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 588858003783 L,D-transpeptidase; Provisional; Region: PRK10190 588858003784 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 588858003785 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 588858003786 transcription-repair coupling factor; Provisional; Region: PRK10689 588858003787 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 588858003788 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 588858003789 ATP binding site [chemical binding]; other site 588858003790 putative Mg++ binding site [ion binding]; other site 588858003791 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 588858003792 nucleotide binding region [chemical binding]; other site 588858003793 ATP-binding site [chemical binding]; other site 588858003794 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 588858003795 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 588858003796 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 588858003797 FtsX-like permease family; Region: FtsX; pfam02687 588858003798 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 588858003799 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 588858003800 Walker A/P-loop; other site 588858003801 ATP binding site [chemical binding]; other site 588858003802 Q-loop/lid; other site 588858003803 ABC transporter signature motif; other site 588858003804 Walker B; other site 588858003805 D-loop; other site 588858003806 H-loop/switch region; other site 588858003807 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 588858003808 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 588858003809 FtsX-like permease family; Region: FtsX; pfam02687 588858003810 fructokinase; Reviewed; Region: PRK09557 588858003811 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 588858003812 nucleotide binding site [chemical binding]; other site 588858003813 NAD-dependent deacetylase; Provisional; Region: PRK00481 588858003814 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 588858003815 NAD+ binding site [chemical binding]; other site 588858003816 substrate binding site [chemical binding]; other site 588858003817 Zn binding site [ion binding]; other site 588858003818 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 588858003819 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 588858003820 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 588858003821 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858003822 dimer interface [polypeptide binding]; other site 588858003823 conserved gate region; other site 588858003824 putative PBP binding loops; other site 588858003825 ABC-ATPase subunit interface; other site 588858003826 Sif protein; Region: Sif; pfam06767 588858003827 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 588858003828 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858003829 dimer interface [polypeptide binding]; other site 588858003830 conserved gate region; other site 588858003831 putative PBP binding loops; other site 588858003832 ABC-ATPase subunit interface; other site 588858003833 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 588858003834 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 588858003835 Walker A/P-loop; other site 588858003836 ATP binding site [chemical binding]; other site 588858003837 Q-loop/lid; other site 588858003838 ABC transporter signature motif; other site 588858003839 Walker B; other site 588858003840 D-loop; other site 588858003841 H-loop/switch region; other site 588858003842 TOBE domain; Region: TOBE_2; pfam08402 588858003843 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 588858003844 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 588858003845 metal binding site [ion binding]; metal-binding site 588858003846 dimer interface [polypeptide binding]; other site 588858003847 putative periplasmic protein; disrupted by IS element 588858003848 Transposase IS200 like; Region: Y1_Tnp; pfam01797 588858003849 Uncharacterized conserved protein [Function unknown]; Region: COG2850 588858003850 Cupin-like domain; Region: Cupin_8; pfam13621 588858003851 sensor protein PhoQ; Provisional; Region: PRK10815 588858003852 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 588858003853 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 588858003854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 588858003855 ATP binding site [chemical binding]; other site 588858003856 Mg2+ binding site [ion binding]; other site 588858003857 G-X-G motif; other site 588858003858 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 588858003859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 588858003860 active site 588858003861 phosphorylation site [posttranslational modification] 588858003862 intermolecular recognition site; other site 588858003863 dimerization interface [polypeptide binding]; other site 588858003864 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 588858003865 DNA binding site [nucleotide binding] 588858003866 adenylosuccinate lyase; Provisional; Region: PRK09285 588858003867 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 588858003868 tetramer interface [polypeptide binding]; other site 588858003869 active site 588858003870 putative lysogenization regulator; Reviewed; Region: PRK00218 588858003871 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 588858003872 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 588858003873 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 588858003874 nudix motif; other site 588858003875 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 588858003876 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 588858003877 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 588858003878 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 588858003879 probable active site [active] 588858003880 isocitrate dehydrogenase; Validated; Region: PRK07362 588858003881 isocitrate dehydrogenase; Reviewed; Region: PRK07006 588858003882 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 588858003883 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 588858003884 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 588858003885 dimer interface [polypeptide binding]; other site 588858003886 active site 588858003887 Int/Topo IB signature motif; other site 588858003888 recombination and repair protein RecT; Reviewed; Region: recT; PRK09846 588858003889 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 588858003890 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 588858003891 P-loop; other site 588858003892 Magnesium ion binding site [ion binding]; other site 588858003893 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 588858003894 Magnesium ion binding site [ion binding]; other site 588858003895 transcriptional repressor DicA; Reviewed; Region: PRK09706 588858003896 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 588858003897 non-specific DNA binding site [nucleotide binding]; other site 588858003898 sequence-specific DNA binding site [nucleotide binding]; other site 588858003899 salt bridge; other site 588858003900 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 588858003901 Bacteriophage CII protein; Region: Phage_CII; pfam05269 588858003902 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 588858003903 Replication protein P; Region: Phage_lambda_P; pfam06992 588858003904 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 588858003905 Methyltransferase domain; Region: Methyltransf_25; pfam13649 588858003906 Protein of unknown function (DUF550); Region: DUF550; pfam04447 588858003907 Protein of unknown function (DUF551); Region: DUF551; pfam04448 588858003908 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 588858003909 DinI-like family; Region: DinI; pfam06183 588858003910 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 588858003911 Protein of unknown function (DUF968); Region: DUF968; pfam06147 588858003912 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 588858003913 Protein of unknown function (DUF1133); Region: DUF1133; pfam06576 588858003914 ORF6N domain; Region: ORF6N; pfam10543 588858003915 Protein of unknown function (DUF2441); Region: DUF2441; pfam10386 588858003916 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 588858003917 catalytic residues [active] 588858003918 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 588858003919 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 588858003920 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 588858003921 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 588858003922 gpW; Region: gpW; pfam02831 588858003923 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 588858003924 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 588858003925 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 588858003926 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 588858003927 tandem repeat interface [polypeptide binding]; other site 588858003928 oligomer interface [polypeptide binding]; other site 588858003929 active site residues [active] 588858003930 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 588858003931 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 588858003932 DNA packaging-like protein; disrupted by frameshift 588858003933 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; cl05094 588858003934 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 588858003935 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 588858003936 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 588858003937 Probable transposase; Region: OrfB_IS605; pfam01385 588858003938 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 588858003939 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 588858003940 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 588858003941 Phage tail protein; Region: Phage_tail_3; pfam08813 588858003942 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 588858003943 Minor tail protein T; Region: Phage_tail_T; pfam06223 588858003944 Phage-related minor tail protein [Function unknown]; Region: COG5281 588858003945 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 588858003946 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 588858003947 Phage-related protein [Function unknown]; Region: COG4718 588858003948 Phage-related protein [Function unknown]; Region: gp18; COG4672 588858003949 Phage-related protein, tail component [Function unknown]; Region: COG4723 588858003950 Phage-related protein, tail component [Function unknown]; Region: COG4733 588858003951 Putative phage tail protein; Region: Phage-tail_3; pfam13550 588858003952 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 588858003953 Interdomain contacts; other site 588858003954 Cytokine receptor motif; other site 588858003955 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 588858003956 Fibronectin type III protein; Region: DUF3672; pfam12421 588858003957 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 588858003958 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 588858003959 Phage Tail Collar Domain; Region: Collar; pfam07484 588858003960 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 588858003961 Winged helix-turn helix; Region: HTH_29; pfam13551 588858003962 Helix-turn-helix domain; Region: HTH_28; pfam13518 588858003963 putative integrase; disrupted by frameshift 588858003964 E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387 588858003965 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 588858003966 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 588858003967 Leucine-rich repeats, bacterial type; Region: LRR_BAC; smart00364 588858003968 hypothetical protein; Provisional; Region: PRK09951 588858003969 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 588858003970 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 588858003971 DinI-like family; Region: DinI; pfam06183 588858003972 Ricin-type beta-trefoil; Region: RICIN; smart00458 588858003973 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 588858003974 putative sugar binding sites [chemical binding]; other site 588858003975 Q-X-W motif; other site 588858003976 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 588858003977 DNA-binding site [nucleotide binding]; DNA binding site 588858003978 RNA-binding motif; other site 588858003979 pseudogene; in-frame stop following codon 4 588858003980 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 588858003981 pseudogene; frameshift 588858003982 lysozyme inhibitor; Provisional; Region: PRK13791 588858003983 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 588858003984 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 588858003985 putative dimer interface [polypeptide binding]; other site 588858003986 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 588858003987 BNR repeat-like domain; Region: BNR_2; pfam13088 588858003988 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 588858003989 TRL-like protein family; Region: TRL; pfam13146 588858003990 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 588858003991 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 588858003992 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 588858003993 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858003994 dimer interface [polypeptide binding]; other site 588858003995 conserved gate region; other site 588858003996 ABC-ATPase subunit interface; other site 588858003997 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 588858003998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858003999 dimer interface [polypeptide binding]; other site 588858004000 conserved gate region; other site 588858004001 putative PBP binding loops; other site 588858004002 ABC-ATPase subunit interface; other site 588858004003 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 588858004004 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 588858004005 Walker A/P-loop; other site 588858004006 ATP binding site [chemical binding]; other site 588858004007 Q-loop/lid; other site 588858004008 ABC transporter signature motif; other site 588858004009 Walker B; other site 588858004010 D-loop; other site 588858004011 H-loop/switch region; other site 588858004012 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 588858004013 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 588858004014 Walker A/P-loop; other site 588858004015 ATP binding site [chemical binding]; other site 588858004016 Q-loop/lid; other site 588858004017 ABC transporter signature motif; other site 588858004018 Walker B; other site 588858004019 D-loop; other site 588858004020 H-loop/switch region; other site 588858004021 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 588858004022 Mechanosensitive ion channel; Region: MS_channel; pfam00924 588858004023 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 588858004024 dimerization interface [polypeptide binding]; other site 588858004025 zinc/cadmium-binding protein; Provisional; Region: PRK10306 588858004026 aminoglycoside resistance protein; Provisional; Region: PRK13746 588858004027 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 588858004028 active site 588858004029 NTP binding site [chemical binding]; other site 588858004030 metal binding triad [ion binding]; metal-binding site 588858004031 antibiotic binding site [chemical binding]; other site 588858004032 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 588858004033 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 588858004034 DNA binding residues [nucleotide binding] 588858004035 transcriptional regulator MirA; Provisional; Region: PRK15043 588858004036 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 588858004037 DNA binding residues [nucleotide binding] 588858004038 dimer interface [polypeptide binding]; other site 588858004039 Pleckstrin homology-like domain; Region: PH-like; cl17171 588858004040 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 588858004041 chorismate mutase; Provisional; Region: PRK08055 588858004042 leucine export protein LeuE; Provisional; Region: PRK10958 588858004043 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 588858004044 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 588858004045 hypothetical protein; Provisional; Region: PRK10457 588858004046 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 588858004047 murein hydrolase B; Provisional; Region: PRK10760; cl17906 588858004048 Domain of unknown function (DUF333); Region: DUF333; pfam03891 588858004049 Uncharacterized conserved protein [Function unknown]; Region: COG3189 588858004050 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 588858004051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858004052 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 588858004053 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 588858004054 Predicted membrane protein [Function unknown]; Region: COG2707 588858004055 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 588858004056 putative deacylase active site [active] 588858004057 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 588858004058 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 588858004059 metal binding site [ion binding]; metal-binding site 588858004060 active site 588858004061 I-site; other site 588858004062 hypothetical protein; Provisional; Region: PRK05325 588858004063 PrkA family serine protein kinase; Provisional; Region: PRK15455 588858004064 AAA ATPase domain; Region: AAA_16; pfam13191 588858004065 Walker A motif; other site 588858004066 ATP binding site [chemical binding]; other site 588858004067 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 588858004068 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 588858004069 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 588858004070 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 588858004071 FeS/SAM binding site; other site 588858004072 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 588858004073 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 588858004074 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 588858004075 active site 588858004076 catalytic tetrad [active] 588858004077 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 588858004078 active site 588858004079 phosphate binding residues; other site 588858004080 catalytic residues [active] 588858004081 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 588858004082 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 588858004083 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 588858004084 methionine sulfoxide reductase B; Provisional; Region: PRK00222 588858004085 SelR domain; Region: SelR; pfam01641 588858004086 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 588858004087 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 588858004088 Isochorismatase family; Region: Isochorismatase; pfam00857 588858004089 catalytic triad [active] 588858004090 metal binding site [ion binding]; metal-binding site 588858004091 conserved cis-peptide bond; other site 588858004092 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 588858004093 active site 588858004094 homodimer interface [polypeptide binding]; other site 588858004095 protease 4; Provisional; Region: PRK10949 588858004096 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 588858004097 tandem repeat interface [polypeptide binding]; other site 588858004098 oligomer interface [polypeptide binding]; other site 588858004099 active site residues [active] 588858004100 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 588858004101 tandem repeat interface [polypeptide binding]; other site 588858004102 oligomer interface [polypeptide binding]; other site 588858004103 active site residues [active] 588858004104 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 588858004105 putative FMN binding site [chemical binding]; other site 588858004106 selenophosphate synthetase; Provisional; Region: PRK00943 588858004107 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 588858004108 dimerization interface [polypeptide binding]; other site 588858004109 putative ATP binding site [chemical binding]; other site 588858004110 DNA topoisomerase III; Provisional; Region: PRK07726 588858004111 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 588858004112 active site 588858004113 putative interdomain interaction site [polypeptide binding]; other site 588858004114 putative metal-binding site [ion binding]; other site 588858004115 putative nucleotide binding site [chemical binding]; other site 588858004116 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 588858004117 domain I; other site 588858004118 DNA binding groove [nucleotide binding] 588858004119 phosphate binding site [ion binding]; other site 588858004120 domain II; other site 588858004121 domain III; other site 588858004122 nucleotide binding site [chemical binding]; other site 588858004123 catalytic site [active] 588858004124 domain IV; other site 588858004125 glutamate dehydrogenase; Provisional; Region: PRK09414 588858004126 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 588858004127 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 588858004128 NAD(P) binding site [chemical binding]; other site 588858004129 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 588858004130 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 588858004131 active site 588858004132 8-oxo-dGMP binding site [chemical binding]; other site 588858004133 nudix motif; other site 588858004134 metal binding site [ion binding]; metal-binding site 588858004135 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 588858004136 putative catalytic site [active] 588858004137 putative phosphate binding site [ion binding]; other site 588858004138 active site 588858004139 metal binding site A [ion binding]; metal-binding site 588858004140 DNA binding site [nucleotide binding] 588858004141 putative AP binding site [nucleotide binding]; other site 588858004142 putative metal binding site B [ion binding]; other site 588858004143 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 588858004144 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 588858004145 inhibitor-cofactor binding pocket; inhibition site 588858004146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858004147 catalytic residue [active] 588858004148 arginine succinyltransferase; Provisional; Region: PRK10456 588858004149 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 588858004150 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 588858004151 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 588858004152 NAD(P) binding site [chemical binding]; other site 588858004153 catalytic residues [active] 588858004154 succinylarginine dihydrolase; Provisional; Region: PRK13281 588858004155 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 588858004156 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 588858004157 putative active site [active] 588858004158 Zn binding site [ion binding]; other site 588858004159 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 588858004160 dimer interface [polypeptide binding]; other site 588858004161 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 588858004162 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 588858004163 GIY-YIG motif/motif A; other site 588858004164 active site 588858004165 catalytic site [active] 588858004166 putative DNA binding site [nucleotide binding]; other site 588858004167 metal binding site [ion binding]; metal-binding site 588858004168 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 588858004169 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 588858004170 homodimer interface [polypeptide binding]; other site 588858004171 NAD binding pocket [chemical binding]; other site 588858004172 ATP binding pocket [chemical binding]; other site 588858004173 Mg binding site [ion binding]; other site 588858004174 active-site loop [active] 588858004175 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 588858004176 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 588858004177 active site 588858004178 P-loop; other site 588858004179 phosphorylation site [posttranslational modification] 588858004180 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 588858004181 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 588858004182 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 588858004183 methionine cluster; other site 588858004184 active site 588858004185 phosphorylation site [posttranslational modification] 588858004186 metal binding site [ion binding]; metal-binding site 588858004187 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 588858004188 Cupin domain; Region: Cupin_2; pfam07883 588858004189 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 588858004190 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 588858004191 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 588858004192 NAD binding site [chemical binding]; other site 588858004193 sugar binding site [chemical binding]; other site 588858004194 divalent metal binding site [ion binding]; other site 588858004195 tetramer (dimer of dimers) interface [polypeptide binding]; other site 588858004196 dimer interface [polypeptide binding]; other site 588858004197 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 588858004198 putative active site [active] 588858004199 YdjC motif; other site 588858004200 Mg binding site [ion binding]; other site 588858004201 putative homodimer interface [polypeptide binding]; other site 588858004202 hydroperoxidase II; Provisional; Region: katE; PRK11249 588858004203 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 588858004204 tetramer interface [polypeptide binding]; other site 588858004205 heme binding pocket [chemical binding]; other site 588858004206 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 588858004207 domain interactions; other site 588858004208 cell division modulator; Provisional; Region: PRK10113 588858004209 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 588858004210 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 588858004211 inner membrane protein; Provisional; Region: PRK11648 588858004212 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 588858004213 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 588858004214 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 588858004215 motif II; other site 588858004216 YniB-like protein; Region: YniB; pfam14002 588858004217 Phosphotransferase enzyme family; Region: APH; pfam01636 588858004218 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 588858004219 active site 588858004220 ATP binding site [chemical binding]; other site 588858004221 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 588858004222 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 588858004223 6-phosphofructokinase 2; Provisional; Region: PRK10294 588858004224 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 588858004225 putative substrate binding site [chemical binding]; other site 588858004226 putative ATP binding site [chemical binding]; other site 588858004227 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 588858004228 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528 588858004229 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 588858004230 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 588858004231 active site 588858004232 substrate binding site [chemical binding]; other site 588858004233 Mg2+ binding site [ion binding]; other site 588858004234 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 588858004235 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 588858004236 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 588858004237 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 588858004238 active site 588858004239 dimer interface [polypeptide binding]; other site 588858004240 motif 1; other site 588858004241 motif 2; other site 588858004242 motif 3; other site 588858004243 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 588858004244 anticodon binding site; other site 588858004245 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 588858004246 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 588858004247 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 588858004248 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 588858004249 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 588858004250 23S rRNA binding site [nucleotide binding]; other site 588858004251 L21 binding site [polypeptide binding]; other site 588858004252 L13 binding site [polypeptide binding]; other site 588858004253 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 588858004254 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 588858004255 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 588858004256 dimer interface [polypeptide binding]; other site 588858004257 motif 1; other site 588858004258 active site 588858004259 motif 2; other site 588858004260 motif 3; other site 588858004261 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 588858004262 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 588858004263 putative tRNA-binding site [nucleotide binding]; other site 588858004264 B3/4 domain; Region: B3_4; pfam03483 588858004265 tRNA synthetase B5 domain; Region: B5; smart00874 588858004266 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 588858004267 dimer interface [polypeptide binding]; other site 588858004268 motif 1; other site 588858004269 motif 3; other site 588858004270 motif 2; other site 588858004271 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 588858004272 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 588858004273 IHF dimer interface [polypeptide binding]; other site 588858004274 IHF - DNA interface [nucleotide binding]; other site 588858004275 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 588858004276 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 588858004277 ABC-ATPase subunit interface; other site 588858004278 dimer interface [polypeptide binding]; other site 588858004279 putative PBP binding regions; other site 588858004280 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 588858004281 catalytic residues [active] 588858004282 dimer interface [polypeptide binding]; other site 588858004283 ABC-type cobalamin transport system, ATPase component [Coenzyme metabolism]; Region: BtuD; COG4138 588858004284 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 588858004285 Walker A/P-loop; other site 588858004286 ATP binding site [chemical binding]; other site 588858004287 Q-loop/lid; other site 588858004288 ABC transporter signature motif; other site 588858004289 Walker B; other site 588858004290 D-loop; other site 588858004291 H-loop/switch region; other site 588858004292 NlpC/P60 family; Region: NLPC_P60; pfam00877 588858004293 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 588858004294 Uncharacterized conserved protein [Function unknown]; Region: COG0397 588858004295 hypothetical protein; Validated; Region: PRK00029 588858004296 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 588858004297 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 588858004298 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 588858004299 PEP synthetase regulatory protein; Provisional; Region: PRK05339 588858004300 phosphoenolpyruvate synthase; Validated; Region: PRK06464 588858004301 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 588858004302 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 588858004303 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 588858004304 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 588858004305 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 588858004306 acyl-activating enzyme (AAE) consensus motif; other site 588858004307 putative AMP binding site [chemical binding]; other site 588858004308 putative active site [active] 588858004309 putative CoA binding site [chemical binding]; other site 588858004310 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 588858004311 oxidoreductase; Provisional; Region: PRK10015 588858004312 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 588858004313 Electron transfer flavoprotein domain; Region: ETF; smart00893 588858004314 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 588858004315 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 588858004316 Ligand binding site [chemical binding]; other site 588858004317 Electron transfer flavoprotein domain; Region: ETF; pfam01012 588858004318 Cupin domain; Region: Cupin_2; pfam07883 588858004319 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 588858004320 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 588858004321 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 588858004322 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 588858004323 active site 588858004324 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 588858004325 Coenzyme A transferase; Region: CoA_trans; smart00882 588858004326 Coenzyme A transferase; Region: CoA_trans; cl17247 588858004327 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 588858004328 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 588858004329 active site 588858004330 catalytic residue [active] 588858004331 dimer interface [polypeptide binding]; other site 588858004332 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 588858004333 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 588858004334 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 588858004335 shikimate binding site; other site 588858004336 NAD(P) binding site [chemical binding]; other site 588858004337 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858004338 putative transporter; Provisional; Region: PRK03699 588858004339 putative substrate translocation pore; other site 588858004340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858004341 Major Facilitator Superfamily; Region: MFS_1; pfam07690 588858004342 putative substrate translocation pore; other site 588858004343 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 588858004344 putative inner membrane protein; Provisional; Region: PRK10983 588858004345 Domain of unknown function DUF20; Region: UPF0118; pfam01594 588858004346 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 588858004347 FAD binding domain; Region: FAD_binding_4; pfam01565 588858004348 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 588858004349 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 588858004350 CoenzymeA binding site [chemical binding]; other site 588858004351 subunit interaction site [polypeptide binding]; other site 588858004352 PHB binding site; other site 588858004353 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 588858004354 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 588858004355 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 588858004356 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 588858004357 putative ABC transporter; Region: ycf24; CHL00085 588858004358 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 588858004359 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 588858004360 Walker A/P-loop; other site 588858004361 ATP binding site [chemical binding]; other site 588858004362 Q-loop/lid; other site 588858004363 ABC transporter signature motif; other site 588858004364 Walker B; other site 588858004365 D-loop; other site 588858004366 H-loop/switch region; other site 588858004367 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 588858004368 FeS assembly protein SufD; Region: sufD; TIGR01981 588858004369 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 588858004370 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 588858004371 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 588858004372 catalytic residue [active] 588858004373 cysteine desufuration protein SufE; Provisional; Region: PRK09296 588858004374 L,D-transpeptidase; Provisional; Region: PRK10190 588858004375 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 588858004376 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 588858004377 murein lipoprotein; Provisional; Region: PRK15396 588858004378 murein lipoprotein; Provisional; Region: PRK15396 588858004379 pyruvate kinase; Provisional; Region: PRK09206 588858004380 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 588858004381 domain interfaces; other site 588858004382 active site 588858004383 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 588858004384 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 588858004385 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 588858004386 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 588858004387 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 588858004388 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 588858004389 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 588858004390 substrate binding site [chemical binding]; other site 588858004391 dimer interface [polypeptide binding]; other site 588858004392 ATP binding site [chemical binding]; other site 588858004393 tetrathionate reductase subunit A; Provisional; Region: PRK14991 588858004394 The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758 588858004395 putative [Fe4-S4] binding site [ion binding]; other site 588858004396 putative molybdopterin cofactor binding site [chemical binding]; other site 588858004397 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 588858004398 putative molybdopterin cofactor binding site; other site 588858004399 tetrathionate reductase subunit C; Provisional; Region: PRK14992 588858004400 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 588858004401 tetrathionate reductase subunit B; Provisional; Region: PRK14993 588858004402 4Fe-4S binding domain; Region: Fer4; pfam00037 588858004403 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 588858004404 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 588858004405 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 588858004406 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 588858004407 dimer interface [polypeptide binding]; other site 588858004408 phosphorylation site [posttranslational modification] 588858004409 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 588858004410 ATP binding site [chemical binding]; other site 588858004411 Mg2+ binding site [ion binding]; other site 588858004412 G-X-G motif; other site 588858004413 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 588858004414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 588858004415 active site 588858004416 phosphorylation site [posttranslational modification] 588858004417 intermolecular recognition site; other site 588858004418 dimerization interface [polypeptide binding]; other site 588858004419 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 588858004420 DNA binding residues [nucleotide binding] 588858004421 dimerization interface [polypeptide binding]; other site 588858004422 hypothetical protein; Provisional; Region: PRK10292 588858004423 Uncharacterized conserved protein [Function unknown]; Region: COG1683 588858004424 Uncharacterized conserved protein [Function unknown]; Region: COG3272 588858004425 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 588858004426 transcriptional regulator MirA; Provisional; Region: PRK15043 588858004427 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 588858004428 DNA binding residues [nucleotide binding] 588858004429 two component system sensor kinase SsrB; Provisional; Region: PRK15369 588858004430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 588858004431 active site 588858004432 phosphorylation site [posttranslational modification] 588858004433 intermolecular recognition site; other site 588858004434 dimerization interface [polypeptide binding]; other site 588858004435 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 588858004436 DNA binding residues [nucleotide binding] 588858004437 dimerization interface [polypeptide binding]; other site 588858004438 two component system sensor kinase SsrA; Provisional; Region: PRK15347 588858004439 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 588858004440 dimerization interface [polypeptide binding]; other site 588858004441 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 588858004442 dimer interface [polypeptide binding]; other site 588858004443 phosphorylation site [posttranslational modification] 588858004444 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 588858004445 ATP binding site [chemical binding]; other site 588858004446 Mg2+ binding site [ion binding]; other site 588858004447 G-X-G motif; other site 588858004448 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 588858004449 active site 588858004450 phosphorylation site [posttranslational modification] 588858004451 intermolecular recognition site; other site 588858004452 dimerization interface [polypeptide binding]; other site 588858004453 pathogenicity island chaperone protein SpiC; Provisional; Region: PRK15368 588858004454 outer membrane secretin SsaC; Provisional; Region: PRK15346 588858004455 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 588858004456 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 588858004457 type III secretion system protein SsaD; Provisional; Region: PRK15367 588858004458 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 588858004459 type III secretion system chaperone SsaE; Provisional; Region: PRK15366 588858004460 type III secretion system chaperone SseA; Provisional; Region: PRK15365 588858004461 pathogenicity island 2 effector protein SseB; Provisional; Region: PRK15364 588858004462 pathogenicity island 2 chaperone protein SscA; Provisional; Region: PRK15363 588858004463 pathogenicity island 2 effector protein SseC; Provisional; Region: PRK15362 588858004464 pathogenicity island 2 effector protein SseD; Provisional; Region: PRK15361 588858004465 pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360 588858004466 type III secretion system chaperone protein SscB; Provisional; Region: PRK15359 588858004467 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 588858004468 TPR motif; other site 588858004469 binding surface 588858004470 pathogenicity island 2 effector protein SseF; Provisional; Region: PRK15358 588858004471 pathogenicity island 2 effector protein SseG; Provisional; Region: PRK15357 588858004472 type III secretion system needle protein SsaG; Provisional; Region: PRK15344 588858004473 type III secretion system protein SsaH; Provisional; Region: PRK15356 588858004474 type III secretion system protein SsaI; Provisional; Region: PRK15355 588858004475 type III secretion system lipoprotein SsaJ; Provisional; Region: PRK15348 588858004476 Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327 588858004477 type III secretion system protein SsaK; Provisional; Region: PRK15354 588858004478 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 588858004479 type III secretion system protein SsaL; Provisional; Region: PRK15345 588858004480 HrpJ-like domain; Region: HrpJ; pfam07201 588858004481 TyeA; Region: TyeA; cl07611 588858004482 type III secretion system protein SsaM; Provisional; Region: PRK15353 588858004483 secretion system apparatus protein SsaV; Provisional; Region: PRK12720 588858004484 FHIPEP family; Region: FHIPEP; pfam00771 588858004485 type III secretion system ATPase SsaN; Validated; Region: PRK07594 588858004486 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 588858004487 Walker A motif; other site 588858004488 ATP binding site [chemical binding]; other site 588858004489 Walker B motif; other site 588858004490 type III secretion system protein SsaO; Provisional; Region: PRK15352 588858004491 type III secretion system protein SsaP; Provisional; Region: PRK15351 588858004492 type III secretion system protein SsaQ; Validated; Region: PRK08035 588858004493 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437 588858004494 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 588858004495 Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790 588858004496 type III secretion system protein SsaS; Provisional; Region: PRK15350 588858004497 type III secretion system protein SsaT; Provisional; Region: PRK15349 588858004498 secretion system apparatus protein SsaU; Reviewed; Region: PRK12721 588858004499 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 588858004500 multidrug efflux protein; Reviewed; Region: PRK01766 588858004501 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 588858004502 cation binding site [ion binding]; other site 588858004503 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 588858004504 Lumazine binding domain; Region: Lum_binding; pfam00677 588858004505 Lumazine binding domain; Region: Lum_binding; pfam00677 588858004506 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 588858004507 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 588858004508 S-adenosylmethionine binding site [chemical binding]; other site 588858004509 putative transporter; Provisional; Region: PRK11043 588858004510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858004511 putative substrate translocation pore; other site 588858004512 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 588858004513 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858004514 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 588858004515 dimerization interface [polypeptide binding]; other site 588858004516 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 588858004517 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 588858004518 DNA binding site [nucleotide binding] 588858004519 domain linker motif; other site 588858004520 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 588858004521 dimerization interface [polypeptide binding]; other site 588858004522 ligand binding site [chemical binding]; other site 588858004523 superoxide dismutase; Provisional; Region: PRK10543 588858004524 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 588858004525 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 588858004526 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 588858004527 NlpC/P60 family; Region: NLPC_P60; pfam00877 588858004528 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 588858004529 putative GSH binding site [chemical binding]; other site 588858004530 catalytic residues [active] 588858004531 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 588858004532 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 588858004533 dimer interface [polypeptide binding]; other site 588858004534 catalytic site [active] 588858004535 putative active site [active] 588858004536 putative substrate binding site [chemical binding]; other site 588858004537 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 588858004538 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 588858004539 dimer interface [polypeptide binding]; other site 588858004540 active site 588858004541 metal binding site [ion binding]; metal-binding site 588858004542 glutathione binding site [chemical binding]; other site 588858004543 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 588858004544 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 588858004545 FMN binding site [chemical binding]; other site 588858004546 active site 588858004547 substrate binding site [chemical binding]; other site 588858004548 catalytic residue [active] 588858004549 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 588858004550 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 588858004551 Predicted Fe-S protein [General function prediction only]; Region: COG3313 588858004552 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 588858004553 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 588858004554 active site 588858004555 catalytic tetrad [active] 588858004556 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 588858004557 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 588858004558 E-class dimer interface [polypeptide binding]; other site 588858004559 P-class dimer interface [polypeptide binding]; other site 588858004560 active site 588858004561 Cu2+ binding site [ion binding]; other site 588858004562 Zn2+ binding site [ion binding]; other site 588858004563 Fusaric acid resistance protein family; Region: FUSC; pfam04632 588858004564 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 588858004565 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 588858004566 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 588858004567 HlyD family secretion protein; Region: HlyD_3; pfam13437 588858004568 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 588858004569 transcriptional regulator SlyA; Provisional; Region: PRK03573 588858004570 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 588858004571 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 588858004572 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 588858004573 lysozyme inhibitor; Provisional; Region: PRK11372 588858004574 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 588858004575 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 588858004576 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 588858004577 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 588858004578 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 588858004579 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 588858004580 active site 588858004581 HIGH motif; other site 588858004582 dimer interface [polypeptide binding]; other site 588858004583 KMSKS motif; other site 588858004584 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 588858004585 RNA binding surface [nucleotide binding]; other site 588858004586 pyridoxamine kinase; Validated; Region: PRK05756 588858004587 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 588858004588 dimer interface [polypeptide binding]; other site 588858004589 pyridoxal binding site [chemical binding]; other site 588858004590 ATP binding site [chemical binding]; other site 588858004591 glutathionine S-transferase; Provisional; Region: PRK10542 588858004592 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 588858004593 C-terminal domain interface [polypeptide binding]; other site 588858004594 GSH binding site (G-site) [chemical binding]; other site 588858004595 dimer interface [polypeptide binding]; other site 588858004596 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 588858004597 dimer interface [polypeptide binding]; other site 588858004598 N-terminal domain interface [polypeptide binding]; other site 588858004599 substrate binding pocket (H-site) [chemical binding]; other site 588858004600 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 588858004601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858004602 putative substrate translocation pore; other site 588858004603 POT family; Region: PTR2; pfam00854 588858004604 endonuclease III; Provisional; Region: PRK10702 588858004605 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 588858004606 minor groove reading motif; other site 588858004607 helix-hairpin-helix signature motif; other site 588858004608 substrate binding pocket [chemical binding]; other site 588858004609 active site 588858004610 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 588858004611 electron transport complex RsxE subunit; Provisional; Region: PRK12405 588858004612 electron transport complex protein RnfG; Validated; Region: PRK01908 588858004613 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 588858004614 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 588858004615 SLBB domain; Region: SLBB; pfam10531 588858004616 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 588858004617 electron transport complex protein RnfB; Provisional; Region: PRK05113 588858004618 Putative Fe-S cluster; Region: FeS; cl17515 588858004619 4Fe-4S binding domain; Region: Fer4; pfam00037 588858004620 electron transport complex protein RsxA; Provisional; Region: PRK05151 588858004621 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 588858004622 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 588858004623 putative oxidoreductase; Provisional; Region: PRK11579 588858004624 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 588858004625 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 588858004626 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 588858004627 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 588858004628 active site 588858004629 purine riboside binding site [chemical binding]; other site 588858004630 pseudogene; in-frame stop following codon 16 588858004631 pseudogene; frameshift 588858004632 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 588858004633 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 588858004634 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 588858004635 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 588858004636 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 588858004637 fumarate hydratase; Provisional; Region: PRK15389 588858004638 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 588858004639 Fumarase C-terminus; Region: Fumerase_C; pfam05683 588858004640 fumarate hydratase; Reviewed; Region: fumC; PRK00485 588858004641 Class II fumarases; Region: Fumarase_classII; cd01362 588858004642 active site 588858004643 tetramer interface [polypeptide binding]; other site 588858004644 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 588858004645 sensor protein RstB; Provisional; Region: PRK10604 588858004646 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 588858004647 dimerization interface [polypeptide binding]; other site 588858004648 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 588858004649 dimer interface [polypeptide binding]; other site 588858004650 phosphorylation site [posttranslational modification] 588858004651 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 588858004652 ATP binding site [chemical binding]; other site 588858004653 Mg2+ binding site [ion binding]; other site 588858004654 G-X-G motif; other site 588858004655 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 588858004656 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 588858004657 active site 588858004658 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 588858004659 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 588858004660 trimer interface [polypeptide binding]; other site 588858004661 eyelet of channel; other site 588858004662 pseudogene; frameshift 588858004663 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 588858004664 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 588858004665 active site 588858004666 phosphorylation site [posttranslational modification] 588858004667 intermolecular recognition site; other site 588858004668 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 588858004669 DNA binding site [nucleotide binding] 588858004670 GlpM protein; Region: GlpM; pfam06942 588858004671 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 588858004672 Spore germination protein; Region: Spore_permease; cl17796 588858004673 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 588858004674 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 588858004675 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 588858004676 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 588858004677 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 588858004678 ligand binding site [chemical binding]; other site 588858004679 homodimer interface [polypeptide binding]; other site 588858004680 NAD(P) binding site [chemical binding]; other site 588858004681 trimer interface B [polypeptide binding]; other site 588858004682 trimer interface A [polypeptide binding]; other site 588858004683 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 588858004684 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 588858004685 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 588858004686 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 588858004687 Domain of unknown function DUF20; Region: UPF0118; pfam01594 588858004688 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 588858004689 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 588858004690 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 588858004691 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 588858004692 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858004693 putative substrate translocation pore; other site 588858004694 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 588858004695 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858004696 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 588858004697 dimerization interface [polypeptide binding]; other site 588858004698 substrate binding pocket [chemical binding]; other site 588858004699 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 588858004700 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 588858004701 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 588858004702 putative dithiobiotin synthetase; Provisional; Region: PRK12374 588858004703 AAA domain; Region: AAA_26; pfam13500 588858004704 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 588858004705 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 588858004706 Cl- selectivity filter; other site 588858004707 Cl- binding residues [ion binding]; other site 588858004708 pore gating glutamate residue; other site 588858004709 dimer interface [polypeptide binding]; other site 588858004710 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 588858004711 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 588858004712 Walker A/P-loop; other site 588858004713 ATP binding site [chemical binding]; other site 588858004714 Q-loop/lid; other site 588858004715 ABC transporter signature motif; other site 588858004716 Walker B; other site 588858004717 D-loop; other site 588858004718 H-loop/switch region; other site 588858004719 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 588858004720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858004721 dimer interface [polypeptide binding]; other site 588858004722 conserved gate region; other site 588858004723 ABC-ATPase subunit interface; other site 588858004724 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 588858004725 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858004726 dimer interface [polypeptide binding]; other site 588858004727 conserved gate region; other site 588858004728 putative PBP binding loops; other site 588858004729 ABC-ATPase subunit interface; other site 588858004730 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 588858004731 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 588858004732 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 588858004733 4Fe-4S binding domain; Region: Fer4; pfam00037 588858004734 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 588858004735 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 588858004736 putative [Fe4-S4] binding site [ion binding]; other site 588858004737 putative molybdopterin cofactor binding site [chemical binding]; other site 588858004738 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 588858004739 putative molybdopterin cofactor binding site; other site 588858004740 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 588858004741 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 588858004742 putative [Fe4-S4] binding site [ion binding]; other site 588858004743 putative molybdopterin cofactor binding site [chemical binding]; other site 588858004744 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 588858004745 putative molybdopterin cofactor binding site; other site 588858004746 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 588858004747 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 588858004748 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 588858004749 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 588858004750 Coenzyme A binding pocket [chemical binding]; other site 588858004751 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 588858004752 hypothetical protein; Provisional; Region: PRK13659 588858004753 hypothetical protein; Provisional; Region: PRK02237 588858004754 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 588858004755 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 588858004756 putative active site pocket [active] 588858004757 putative metal binding site [ion binding]; other site 588858004758 putative oxidoreductase; Provisional; Region: PRK10083 588858004759 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 588858004760 putative NAD(P) binding site [chemical binding]; other site 588858004761 catalytic Zn binding site [ion binding]; other site 588858004762 structural Zn binding site [ion binding]; other site 588858004763 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 588858004764 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 588858004765 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 588858004766 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 588858004767 Transcriptional regulators [Transcription]; Region: GntR; COG1802 588858004768 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 588858004769 DNA-binding site [nucleotide binding]; DNA binding site 588858004770 FCD domain; Region: FCD; pfam07729 588858004771 malonic semialdehyde reductase; Provisional; Region: PRK10538 588858004772 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 588858004773 putative NAD(P) binding site [chemical binding]; other site 588858004774 homodimer interface [polypeptide binding]; other site 588858004775 homotetramer interface [polypeptide binding]; other site 588858004776 active site 588858004777 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 588858004778 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 588858004779 active site 588858004780 Zn binding site [ion binding]; other site 588858004781 General stress protein [General function prediction only]; Region: GsiB; COG3729 588858004782 hypothetical protein; Validated; Region: PRK03657 588858004783 hypothetical protein; Provisional; Region: PRK10053 588858004784 putative transporter; Provisional; Region: PRK10054 588858004785 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858004786 putative substrate translocation pore; other site 588858004787 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 588858004788 EamA-like transporter family; Region: EamA; pfam00892 588858004789 MarB protein; Region: MarB; pfam13999 588858004790 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 588858004791 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 588858004792 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 588858004793 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 588858004794 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 588858004795 inner membrane protein; Provisional; Region: PRK10995 588858004796 putative arabinose transporter; Provisional; Region: PRK03545 588858004797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858004798 putative substrate translocation pore; other site 588858004799 Transcriptional regulator [Transcription]; Region: LysR; COG0583 588858004800 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858004801 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 588858004802 putative dimerization interface [polypeptide binding]; other site 588858004803 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 588858004804 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 588858004805 NAD(P) binding site [chemical binding]; other site 588858004806 catalytic residues [active] 588858004807 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 588858004808 glutaminase; Provisional; Region: PRK00971 588858004809 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 588858004810 Predicted membrane protein [Function unknown]; Region: COG3781 588858004811 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 588858004812 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 588858004813 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 588858004814 trimer interface [polypeptide binding]; other site 588858004815 eyelet of channel; other site 588858004816 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 588858004817 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 588858004818 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 588858004819 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 588858004820 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 588858004821 Rubredoxin [Energy production and conversion]; Region: COG1773 588858004822 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 588858004823 iron binding site [ion binding]; other site 588858004824 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 588858004825 HupF/HypC family; Region: HupF_HypC; cl00394 588858004826 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 588858004827 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 588858004828 putative substrate-binding site; other site 588858004829 nickel binding site [ion binding]; other site 588858004830 Ni,Fe-hydrogenase I cytochrome b subunit [Energy production and conversion]; Region: HyaC; COG1969 588858004831 hydrogenase 1 large subunit; Provisional; Region: PRK10170 588858004832 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 588858004833 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 588858004834 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 588858004835 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 588858004836 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 588858004837 active site 588858004838 Transcriptional regulators [Transcription]; Region: FadR; COG2186 588858004839 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 588858004840 DNA-binding site [nucleotide binding]; DNA binding site 588858004841 FCD domain; Region: FCD; pfam07729 588858004842 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 588858004843 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 588858004844 putative NAD(P) binding site [chemical binding]; other site 588858004845 catalytic Zn binding site [ion binding]; other site 588858004846 structural Zn binding site [ion binding]; other site 588858004847 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858004848 D-galactonate transporter; Region: 2A0114; TIGR00893 588858004849 putative substrate translocation pore; other site 588858004850 PhoPQ-activated pathogenicity-related protein [General function prediction only]; Region: PqaA; COG4287 588858004851 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858004852 Major Facilitator Superfamily; Region: MFS_1; pfam07690 588858004853 putative substrate translocation pore; other site 588858004854 hypothetical protein; Provisional; Region: PRK06184 588858004855 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 588858004856 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 588858004857 Transcriptional regulators [Transcription]; Region: MarR; COG1846 588858004858 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 588858004859 putative DNA binding site [nucleotide binding]; other site 588858004860 putative Zn2+ binding site [ion binding]; other site 588858004861 S-adenosylmethionine:tRNA-ribosyltransferase- isomerase (queuine synthetase) [Translation, ribosomal structure and biogenesis]; Region: QueA; COG0809 588858004862 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 588858004863 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 588858004864 homotrimer interaction site [polypeptide binding]; other site 588858004865 putative active site [active] 588858004866 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 588858004867 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 588858004868 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 588858004869 pseudogene; frameshift 588858004870 Transcriptional regulators [Transcription]; Region: PurR; COG1609 588858004871 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 588858004872 DNA binding site [nucleotide binding] 588858004873 domain linker motif; other site 588858004874 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 588858004875 dimerization interface (closed form) [polypeptide binding]; other site 588858004876 ligand binding site [chemical binding]; other site 588858004877 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 588858004878 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 588858004879 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 588858004880 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858004881 homodimer interface [polypeptide binding]; other site 588858004882 catalytic residue [active] 588858004883 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 588858004884 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 588858004885 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 588858004886 active site 588858004887 catalytic site [active] 588858004888 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 588858004889 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 588858004890 active site 588858004891 catalytic site [active] 588858004892 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 588858004893 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 588858004894 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 588858004895 catalytic site [active] 588858004896 active site 588858004897 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 588858004898 Protein of unknown function (DUF1264); Region: DUF1264; pfam06884 588858004899 acid-resistance protein; Provisional; Region: hdeB; PRK11566 588858004900 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 588858004901 biofilm-dependent modulation protein; Provisional; Region: PRK11436 588858004902 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 588858004903 malate dehydrogenase; Provisional; Region: PRK13529 588858004904 Malic enzyme, N-terminal domain; Region: malic; pfam00390 588858004905 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 588858004906 NAD(P) binding site [chemical binding]; other site 588858004907 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 588858004908 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 588858004909 NAD binding site [chemical binding]; other site 588858004910 substrate binding site [chemical binding]; other site 588858004911 catalytic Zn binding site [ion binding]; other site 588858004912 tetramer interface [polypeptide binding]; other site 588858004913 structural Zn binding site [ion binding]; other site 588858004914 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 588858004915 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 588858004916 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 588858004917 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 588858004918 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 588858004919 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 588858004920 [4Fe-4S] binding site [ion binding]; other site 588858004921 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 588858004922 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 588858004923 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 588858004924 molybdopterin cofactor binding site; other site 588858004925 aromatic amino acid exporter; Provisional; Region: PRK11689 588858004926 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 588858004927 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 588858004928 trimer interface [polypeptide binding]; other site 588858004929 eyelet of channel; other site 588858004930 Uncharacterized conserved protein [Function unknown]; Region: COG3791 588858004931 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 588858004932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858004933 putative substrate translocation pore; other site 588858004934 TetR family transcriptional regulator; Provisional; Region: PRK14996 588858004935 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 588858004936 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 588858004937 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 588858004938 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 588858004939 [4Fe-4S] binding site [ion binding]; other site 588858004940 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 588858004941 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 588858004942 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 588858004943 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 588858004944 molybdopterin cofactor binding site; other site 588858004945 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 588858004946 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 588858004947 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 588858004948 hypothetical protein; Provisional; Region: PRK10281 588858004949 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 588858004950 L-asparagine permease; Provisional; Region: PRK15049 588858004951 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 588858004952 Uncharacterized conserved protein [Function unknown]; Region: COG3391 588858004953 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 588858004954 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 588858004955 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 588858004956 N-terminal plug; other site 588858004957 ligand-binding site [chemical binding]; other site 588858004958 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 588858004959 DNA-binding site [nucleotide binding]; DNA binding site 588858004960 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 588858004961 FCD domain; Region: FCD; pfam07729 588858004962 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 588858004963 Prostaglandin dehydrogenases; Region: PGDH; cd05288 588858004964 NAD(P) binding site [chemical binding]; other site 588858004965 substrate binding site [chemical binding]; other site 588858004966 dimer interface [polypeptide binding]; other site 588858004967 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 588858004968 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 588858004969 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 588858004970 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 588858004971 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfB; COG4457 588858004972 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458 588858004973 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 588858004974 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 588858004975 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 588858004976 tetrameric interface [polypeptide binding]; other site 588858004977 NAD binding site [chemical binding]; other site 588858004978 catalytic residues [active] 588858004979 substrate binding site [chemical binding]; other site 588858004980 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 588858004981 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 588858004982 DNA-binding site [nucleotide binding]; DNA binding site 588858004983 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 588858004984 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858004985 homodimer interface [polypeptide binding]; other site 588858004986 catalytic residue [active] 588858004987 D-alanyl-D-alanine dipeptidase [Cell envelope biogenesis, outer membrane]; Region: DdpX; COG2173 588858004988 secreted effector protein SifB; Provisional; Region: sifB; PRK09499 588858004989 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 588858004990 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 588858004991 Peptidase family U32; Region: Peptidase_U32; pfam01136 588858004992 Collagenase; Region: DUF3656; pfam12392 588858004993 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 588858004994 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 588858004995 non-specific DNA binding site [nucleotide binding]; other site 588858004996 salt bridge; other site 588858004997 sequence-specific DNA binding site [nucleotide binding]; other site 588858004998 Cupin domain; Region: Cupin_2; pfam07883 588858004999 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 588858005000 benzoate transporter; Region: benE; TIGR00843 588858005001 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 588858005002 tellurite resistance protein TehB; Provisional; Region: PRK11207 588858005003 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 588858005004 S-adenosylmethionine binding site [chemical binding]; other site 588858005005 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 588858005006 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 588858005007 gating phenylalanine in ion channel; other site 588858005008 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 588858005009 putative trimer interface [polypeptide binding]; other site 588858005010 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 588858005011 putative trimer interface [polypeptide binding]; other site 588858005012 putative CoA binding site [chemical binding]; other site 588858005013 putative CoA binding site [chemical binding]; other site 588858005014 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 588858005015 putative trimer interface [polypeptide binding]; other site 588858005016 putative CoA binding site [chemical binding]; other site 588858005017 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 588858005018 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 588858005019 Coenzyme A binding pocket [chemical binding]; other site 588858005020 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 588858005021 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 588858005022 oligomer interface [polypeptide binding]; other site 588858005023 active site 588858005024 metal binding site [ion binding]; metal-binding site 588858005025 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 588858005026 active site 588858005027 P-loop; other site 588858005028 phosphorylation site [posttranslational modification] 588858005029 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 588858005030 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 588858005031 membrane complex biogenesis protein, BtpA family; Region: thylakoid_BtpA; TIGR00259 588858005032 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 588858005033 active site 588858005034 phosphorylation site [posttranslational modification] 588858005035 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 588858005036 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 588858005037 substrate binding site [chemical binding]; other site 588858005038 hexamer interface [polypeptide binding]; other site 588858005039 metal binding site [ion binding]; metal-binding site 588858005040 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 588858005041 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 588858005042 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 588858005043 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 588858005044 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 588858005045 Coenzyme A binding pocket [chemical binding]; other site 588858005046 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 588858005047 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 588858005048 teramer interface [polypeptide binding]; other site 588858005049 active site 588858005050 FMN binding site [chemical binding]; other site 588858005051 catalytic residues [active] 588858005052 Uncharacterized conserved protein [Function unknown]; Region: COG2353 588858005053 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 588858005054 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 588858005055 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 588858005056 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 588858005057 substrate binding pocket [chemical binding]; other site 588858005058 catalytic triad [active] 588858005059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 588858005060 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 588858005061 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 588858005062 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858005063 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 588858005064 dimerization interface [polypeptide binding]; other site 588858005065 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 588858005066 dimer interface [polypeptide binding]; other site 588858005067 ligand binding site [chemical binding]; other site 588858005068 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 588858005069 HAMP domain; Region: HAMP; pfam00672 588858005070 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 588858005071 dimer interface [polypeptide binding]; other site 588858005072 putative CheW interface [polypeptide binding]; other site 588858005073 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 588858005074 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 588858005075 substrate binding site [chemical binding]; other site 588858005076 catalytic Zn binding site [ion binding]; other site 588858005077 NAD binding site [chemical binding]; other site 588858005078 structural Zn binding site [ion binding]; other site 588858005079 dimer interface [polypeptide binding]; other site 588858005080 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 588858005081 putative metal binding site [ion binding]; other site 588858005082 putative homodimer interface [polypeptide binding]; other site 588858005083 putative homotetramer interface [polypeptide binding]; other site 588858005084 putative homodimer-homodimer interface [polypeptide binding]; other site 588858005085 putative allosteric switch controlling residues; other site 588858005086 Sif protein; Region: Sif; cl11505 588858005087 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 588858005088 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 588858005089 active site 588858005090 catalytic triad [active] 588858005091 oxyanion hole [active] 588858005092 Predicted membrane protein [Function unknown]; Region: COG3326 588858005093 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 588858005094 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 588858005095 substrate binding pocket [chemical binding]; other site 588858005096 membrane-bound complex binding site; other site 588858005097 hinge residues; other site 588858005098 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 588858005099 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858005100 dimer interface [polypeptide binding]; other site 588858005101 conserved gate region; other site 588858005102 putative PBP binding loops; other site 588858005103 ABC-ATPase subunit interface; other site 588858005104 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 588858005105 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 588858005106 Walker A/P-loop; other site 588858005107 ATP binding site [chemical binding]; other site 588858005108 Q-loop/lid; other site 588858005109 ABC transporter signature motif; other site 588858005110 Walker B; other site 588858005111 D-loop; other site 588858005112 H-loop/switch region; other site 588858005113 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 588858005114 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858005115 dimer interface [polypeptide binding]; other site 588858005116 conserved gate region; other site 588858005117 putative PBP binding loops; other site 588858005118 ABC-ATPase subunit interface; other site 588858005119 Predicted membrane protein [Function unknown]; Region: COG5305 588858005120 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 588858005121 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 588858005122 S-adenosylmethionine binding site [chemical binding]; other site 588858005123 cytochrome b561; Provisional; Region: PRK11513 588858005124 Uncharacterized conserved protein [Function unknown]; Region: COG1434 588858005125 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 588858005126 putative active site [active] 588858005127 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 588858005128 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 588858005129 ATP binding site [chemical binding]; other site 588858005130 putative Mg++ binding site [ion binding]; other site 588858005131 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 588858005132 nucleotide binding region [chemical binding]; other site 588858005133 ATP-binding site [chemical binding]; other site 588858005134 Helicase associated domain (HA2); Region: HA2; pfam04408 588858005135 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 588858005136 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 588858005137 azoreductase; Reviewed; Region: PRK00170 588858005138 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 588858005139 Uncharacterized conserved protein [Function unknown]; Region: COG3791 588858005140 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 588858005141 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 588858005142 hypothetical protein; Provisional; Region: PRK10695 588858005143 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 588858005144 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 588858005145 putative ligand binding site [chemical binding]; other site 588858005146 putative NAD binding site [chemical binding]; other site 588858005147 catalytic site [active] 588858005148 heat-inducible protein; Provisional; Region: PRK10449 588858005149 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 588858005150 Domain of unknown function (DUF333); Region: DUF333; pfam03891 588858005151 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 588858005152 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 588858005153 dimer interface [polypeptide binding]; other site 588858005154 PYR/PP interface [polypeptide binding]; other site 588858005155 TPP binding site [chemical binding]; other site 588858005156 substrate binding site [chemical binding]; other site 588858005157 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 588858005158 Domain of unknown function; Region: EKR; smart00890 588858005159 4Fe-4S binding domain; Region: Fer4_6; pfam12837 588858005160 4Fe-4S binding domain; Region: Fer4; pfam00037 588858005161 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 588858005162 TPP-binding site [chemical binding]; other site 588858005163 dimer interface [polypeptide binding]; other site 588858005164 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 588858005165 Ligand Binding Site [chemical binding]; other site 588858005166 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 588858005167 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 588858005168 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 588858005169 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 588858005170 Ligand Binding Site [chemical binding]; other site 588858005171 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 588858005172 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 588858005173 ATP binding site [chemical binding]; other site 588858005174 Mg++ binding site [ion binding]; other site 588858005175 motif III; other site 588858005176 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 588858005177 nucleotide binding region [chemical binding]; other site 588858005178 ATP-binding site [chemical binding]; other site 588858005179 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 588858005180 putative RNA binding site [nucleotide binding]; other site 588858005181 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 588858005182 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 588858005183 Cl binding site [ion binding]; other site 588858005184 oligomer interface [polypeptide binding]; other site 588858005185 HAMP domain; Region: HAMP; pfam00672 588858005186 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 588858005187 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 588858005188 dimer interface [polypeptide binding]; other site 588858005189 putative CheW interface [polypeptide binding]; other site 588858005190 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 588858005191 Smr domain; Region: Smr; pfam01713 588858005192 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 588858005193 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 588858005194 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 588858005195 DNA binding site [nucleotide binding] 588858005196 active site 588858005197 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 588858005198 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 588858005199 ligand binding site [chemical binding]; other site 588858005200 flexible hinge region; other site 588858005201 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 588858005202 putative switch regulator; other site 588858005203 non-specific DNA interactions [nucleotide binding]; other site 588858005204 DNA binding site [nucleotide binding] 588858005205 sequence specific DNA binding site [nucleotide binding]; other site 588858005206 putative cAMP binding site [chemical binding]; other site 588858005207 universal stress protein UspE; Provisional; Region: PRK11175 588858005208 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 588858005209 Ligand Binding Site [chemical binding]; other site 588858005210 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 588858005211 Ligand Binding Site [chemical binding]; other site 588858005212 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 588858005213 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 588858005214 Mechanosensitive ion channel; Region: MS_channel; pfam00924 588858005215 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 588858005216 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 588858005217 non-specific DNA binding site [nucleotide binding]; other site 588858005218 salt bridge; other site 588858005219 sequence-specific DNA binding site [nucleotide binding]; other site 588858005220 Cupin domain; Region: Cupin_2; pfam07883 588858005221 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 588858005222 B3/4 domain; Region: B3_4; pfam03483 588858005223 pseudogene; in-frame stop following codon 24 588858005224 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: Tpx; COG2077 588858005225 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 588858005226 similar to Escherichia coli putative AraC-type regulatory protein (AAC73403.1); AraC family; helix-turn-helix; disrupted by frameshift 588858005227 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 588858005228 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 588858005229 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 588858005230 oxidoreductase; Provisional; Region: PRK12742 588858005231 classical (c) SDRs; Region: SDR_c; cd05233 588858005232 NAD(P) binding site [chemical binding]; other site 588858005233 active site 588858005234 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 588858005235 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 588858005236 active site 588858005237 catalytic tetrad [active] 588858005238 Transcriptional regulator [Transcription]; Region: LysR; COG0583 588858005239 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858005240 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 588858005241 putative effector binding pocket; other site 588858005242 putative dimerization interface [polypeptide binding]; other site 588858005243 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 588858005244 NmrA-like family; Region: NmrA; pfam05368 588858005245 NAD(P) binding site [chemical binding]; other site 588858005246 active site lysine 588858005247 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 588858005248 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 588858005249 peptide binding site [polypeptide binding]; other site 588858005250 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 588858005251 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 588858005252 putative active site [active] 588858005253 Zn binding site [ion binding]; other site 588858005254 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 588858005255 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 588858005256 active site 588858005257 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 588858005258 dimer interface [polypeptide binding]; other site 588858005259 catalytic triad [active] 588858005260 peroxidatic and resolving cysteines [active] 588858005261 Transposase IS200 like; Region: Y1_Tnp; pfam01797 588858005262 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 588858005263 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 588858005264 putative aromatic amino acid binding site; other site 588858005265 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 588858005266 Walker A motif; other site 588858005267 ATP binding site [chemical binding]; other site 588858005268 Walker B motif; other site 588858005269 arginine finger; other site 588858005270 hypothetical protein; Provisional; Region: PRK05415 588858005271 TIGR01620 family protein; Region: hyp_HI0043 588858005272 Predicted ATPase [General function prediction only]; Region: COG3106 588858005273 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 588858005274 active site residue [active] 588858005275 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 588858005276 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 588858005277 phage shock protein C; Region: phageshock_pspC; TIGR02978 588858005278 phage shock protein B; Provisional; Region: pspB; PRK09458 588858005279 phage shock protein PspA; Provisional; Region: PRK10698 588858005280 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 588858005281 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 588858005282 Walker A motif; other site 588858005283 ATP binding site [chemical binding]; other site 588858005284 Walker B motif; other site 588858005285 arginine finger; other site 588858005286 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 588858005287 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 588858005288 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 588858005289 peptide binding site [polypeptide binding]; other site 588858005290 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 588858005291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858005292 dimer interface [polypeptide binding]; other site 588858005293 conserved gate region; other site 588858005294 putative PBP binding loops; other site 588858005295 ABC-ATPase subunit interface; other site 588858005296 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 588858005297 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 588858005298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858005299 dimer interface [polypeptide binding]; other site 588858005300 conserved gate region; other site 588858005301 putative PBP binding loops; other site 588858005302 ABC-ATPase subunit interface; other site 588858005303 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 588858005304 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 588858005305 Walker A/P-loop; other site 588858005306 ATP binding site [chemical binding]; other site 588858005307 Q-loop/lid; other site 588858005308 ABC transporter signature motif; other site 588858005309 Walker B; other site 588858005310 D-loop; other site 588858005311 H-loop/switch region; other site 588858005312 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 588858005313 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 588858005314 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 588858005315 Walker A/P-loop; other site 588858005316 ATP binding site [chemical binding]; other site 588858005317 Q-loop/lid; other site 588858005318 ABC transporter signature motif; other site 588858005319 Walker B; other site 588858005320 D-loop; other site 588858005321 H-loop/switch region; other site 588858005322 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 588858005323 Protein kinase domain; Region: Pkinase; pfam00069 588858005324 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 588858005325 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 588858005326 NAD binding site [chemical binding]; other site 588858005327 homotetramer interface [polypeptide binding]; other site 588858005328 homodimer interface [polypeptide binding]; other site 588858005329 substrate binding site [chemical binding]; other site 588858005330 active site 588858005331 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 588858005332 Uncharacterized conserved protein [Function unknown]; Region: COG2128 588858005333 exoribonuclease II; Provisional; Region: PRK05054 588858005334 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 588858005335 RNB domain; Region: RNB; pfam00773 588858005336 S1 RNA binding domain; Region: S1; pfam00575 588858005337 RNase II stability modulator; Provisional; Region: PRK10060 588858005338 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 588858005339 putative active site [active] 588858005340 heme pocket [chemical binding]; other site 588858005341 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 588858005342 metal binding site [ion binding]; metal-binding site 588858005343 active site 588858005344 I-site; other site 588858005345 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 588858005346 hypothetical protein; Provisional; Region: PRK13658 588858005347 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 588858005348 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 588858005349 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 588858005350 lipoprotein; Provisional; Region: PRK10540 588858005351 translation initiation factor Sui1; Validated; Region: PRK06824 588858005352 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 588858005353 putative rRNA binding site [nucleotide binding]; other site 588858005354 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 588858005355 active site 588858005356 dimer interface [polypeptide binding]; other site 588858005357 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 588858005358 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 588858005359 binding surface 588858005360 TPR motif; other site 588858005361 Predicted membrane protein [Function unknown]; Region: COG3771 588858005362 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 588858005363 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 588858005364 active site 588858005365 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 588858005366 dimerization interface [polypeptide binding]; other site 588858005367 active site 588858005368 aconitate hydratase; Validated; Region: PRK09277 588858005369 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 588858005370 substrate binding site [chemical binding]; other site 588858005371 ligand binding site [chemical binding]; other site 588858005372 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 588858005373 substrate binding site [chemical binding]; other site 588858005374 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 588858005375 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858005376 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 588858005377 substrate binding site [chemical binding]; other site 588858005378 putative dimerization interface [polypeptide binding]; other site 588858005379 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 588858005380 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 588858005381 active site 588858005382 interdomain interaction site; other site 588858005383 putative metal-binding site [ion binding]; other site 588858005384 nucleotide binding site [chemical binding]; other site 588858005385 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 588858005386 domain I; other site 588858005387 DNA binding groove [nucleotide binding] 588858005388 phosphate binding site [ion binding]; other site 588858005389 domain II; other site 588858005390 domain III; other site 588858005391 nucleotide binding site [chemical binding]; other site 588858005392 catalytic site [active] 588858005393 domain IV; other site 588858005394 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 588858005395 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 588858005396 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 588858005397 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 588858005398 hypothetical protein; Provisional; Region: PRK11037 588858005399 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 588858005400 putative inner membrane peptidase; Provisional; Region: PRK11778 588858005401 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 588858005402 tandem repeat interface [polypeptide binding]; other site 588858005403 oligomer interface [polypeptide binding]; other site 588858005404 active site residues [active] 588858005405 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 588858005406 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 588858005407 NADP binding site [chemical binding]; other site 588858005408 homodimer interface [polypeptide binding]; other site 588858005409 active site 588858005410 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 588858005411 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 588858005412 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 588858005413 homodimer interface [polypeptide binding]; other site 588858005414 Walker A motif; other site 588858005415 ATP binding site [chemical binding]; other site 588858005416 hydroxycobalamin binding site [chemical binding]; other site 588858005417 Walker B motif; other site 588858005418 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 588858005419 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 588858005420 RNA binding surface [nucleotide binding]; other site 588858005421 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 588858005422 probable active site [active] 588858005423 translation factor; disrupted by frameshift 588858005424 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 588858005425 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 588858005426 active site 588858005427 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 588858005428 anthranilate synthase component I; Provisional; Region: PRK13564 588858005429 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 588858005430 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 588858005431 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 588858005432 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 588858005433 glutamine binding [chemical binding]; other site 588858005434 catalytic triad [active] 588858005435 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 588858005436 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 588858005437 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 588858005438 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 588858005439 active site 588858005440 ribulose/triose binding site [chemical binding]; other site 588858005441 phosphate binding site [ion binding]; other site 588858005442 substrate (anthranilate) binding pocket [chemical binding]; other site 588858005443 product (indole) binding pocket [chemical binding]; other site 588858005444 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 588858005445 active site 588858005446 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 588858005447 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 588858005448 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858005449 catalytic residue [active] 588858005450 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 588858005451 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 588858005452 substrate binding site [chemical binding]; other site 588858005453 active site 588858005454 catalytic residues [active] 588858005455 heterodimer interface [polypeptide binding]; other site 588858005456 General stress protein [General function prediction only]; Region: GsiB; COG3729 588858005457 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 588858005458 dimerization interface [polypeptide binding]; other site 588858005459 metal binding site [ion binding]; metal-binding site 588858005460 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 588858005461 dinuclear metal binding motif [ion binding]; other site 588858005462 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 588858005463 dimanganese center [ion binding]; other site 588858005464 outer membrane protein W; Provisional; Region: PRK10959 588858005465 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 588858005466 hypothetical protein; Provisional; Region: PRK02868 588858005467 intracellular septation protein A; Reviewed; Region: PRK00259 588858005468 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 588858005469 transport protein TonB; Provisional; Region: PRK10819 588858005470 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 588858005471 YciI-like protein; Reviewed; Region: PRK11370 588858005472 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 588858005473 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 588858005474 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 588858005475 putative active site [active] 588858005476 catalytic site [active] 588858005477 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 588858005478 putative active site [active] 588858005479 catalytic site [active] 588858005480 dsDNA-mimic protein; Reviewed; Region: PRK05094 588858005481 Ion transport protein; Region: Ion_trans; pfam00520 588858005482 Ion channel; Region: Ion_trans_2; pfam07885 588858005483 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 588858005484 Double zinc ribbon; Region: DZR; pfam12773 588858005485 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 588858005486 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 588858005487 Walker A/P-loop; other site 588858005488 ATP binding site [chemical binding]; other site 588858005489 Q-loop/lid; other site 588858005490 ABC transporter signature motif; other site 588858005491 Walker B; other site 588858005492 D-loop; other site 588858005493 H-loop/switch region; other site 588858005494 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 588858005495 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 588858005496 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 588858005497 Walker A/P-loop; other site 588858005498 ATP binding site [chemical binding]; other site 588858005499 Q-loop/lid; other site 588858005500 ABC transporter signature motif; other site 588858005501 Walker B; other site 588858005502 D-loop; other site 588858005503 H-loop/switch region; other site 588858005504 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 588858005505 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 588858005506 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 588858005507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858005508 dimer interface [polypeptide binding]; other site 588858005509 conserved gate region; other site 588858005510 ABC-ATPase subunit interface; other site 588858005511 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 588858005512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858005513 dimer interface [polypeptide binding]; other site 588858005514 conserved gate region; other site 588858005515 putative PBP binding loops; other site 588858005516 ABC-ATPase subunit interface; other site 588858005517 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 588858005518 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 588858005519 peptide binding site [polypeptide binding]; other site 588858005520 hypothetical protein; Provisional; Region: PRK11111 588858005521 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 588858005522 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 588858005523 putative catalytic cysteine [active] 588858005524 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 588858005525 putative active site [active] 588858005526 metal binding site [ion binding]; metal-binding site 588858005527 thymidine kinase; Provisional; Region: PRK04296 588858005528 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 588858005529 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 588858005530 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 588858005531 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 588858005532 active site 588858005533 tetramer interface; other site 588858005534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 588858005535 active site 588858005536 response regulator of RpoS; Provisional; Region: PRK10693 588858005537 phosphorylation site [posttranslational modification] 588858005538 intermolecular recognition site; other site 588858005539 dimerization interface [polypeptide binding]; other site 588858005540 hypothetical protein; Provisional; Region: PRK10279 588858005541 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 588858005542 active site 588858005543 nucleophile elbow; other site 588858005544 SEC-C motif; Region: SEC-C; pfam02810 588858005545 hypothetical protein; Provisional; Region: PRK04233 588858005546 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 588858005547 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 588858005548 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 588858005549 putative active site [active] 588858005550 putative substrate binding site [chemical binding]; other site 588858005551 putative cosubstrate binding site; other site 588858005552 catalytic site [active] 588858005553 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 588858005554 Sel1-like repeats; Region: SEL1; smart00671 588858005555 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 588858005556 Sel1-like repeats; Region: SEL1; smart00671 588858005557 Sel1-like repeats; Region: SEL1; smart00671 588858005558 Sel1-like repeats; Region: SEL1; smart00671 588858005559 Sel1-like repeats; Region: SEL1; smart00671 588858005560 Sel1-like repeats; Region: SEL1; smart00671 588858005561 Sel1-like repeats; Region: SEL1; smart00671 588858005562 Sel1-like repeats; Region: SEL1; smart00671 588858005563 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 588858005564 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 588858005565 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 588858005566 4Fe-4S binding domain; Region: Fer4; cl02805 588858005567 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 588858005568 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 588858005569 [4Fe-4S] binding site [ion binding]; other site 588858005570 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 588858005571 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 588858005572 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 588858005573 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 588858005574 molybdopterin cofactor binding site; other site 588858005575 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 588858005576 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 588858005577 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 588858005578 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 588858005579 dimerization interface [polypeptide binding]; other site 588858005580 Histidine kinase; Region: HisKA_3; pfam07730 588858005581 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 588858005582 ATP binding site [chemical binding]; other site 588858005583 Mg2+ binding site [ion binding]; other site 588858005584 G-X-G motif; other site 588858005585 transcriptional regulator NarL; Provisional; Region: PRK10651 588858005586 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 588858005587 active site 588858005588 phosphorylation site [posttranslational modification] 588858005589 intermolecular recognition site; other site 588858005590 dimerization interface [polypeptide binding]; other site 588858005591 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 588858005592 DNA binding residues [nucleotide binding] 588858005593 dimerization interface [polypeptide binding]; other site 588858005594 putative invasin; Provisional; Region: PRK10177 588858005595 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 588858005596 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 588858005597 cation transport regulator; Reviewed; Region: chaB; PRK09582 588858005598 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 588858005599 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 588858005600 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 588858005601 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 588858005602 hypothetical protein; Provisional; Region: PRK10941 588858005603 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 588858005604 hypothetical protein; Provisional; Region: PRK10278 588858005605 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 588858005606 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 588858005607 peptide chain release factor 1; Validated; Region: prfA; PRK00591 588858005608 This domain is found in peptide chain release factors; Region: PCRF; smart00937 588858005609 RF-1 domain; Region: RF-1; pfam00472 588858005610 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 588858005611 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 588858005612 tRNA; other site 588858005613 putative tRNA binding site [nucleotide binding]; other site 588858005614 putative NADP binding site [chemical binding]; other site 588858005615 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 588858005616 Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017 588858005617 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 588858005618 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 588858005619 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 588858005620 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 588858005621 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 588858005622 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 588858005623 active site 588858005624 putative transporter; Provisional; Region: PRK11660 588858005625 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 588858005626 Sulfate transporter family; Region: Sulfate_transp; pfam00916 588858005627 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 588858005628 hypothetical protein; Provisional; Region: PRK10692 588858005629 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 588858005630 putative active site [active] 588858005631 catalytic residue [active] 588858005632 GTP-binding protein YchF; Reviewed; Region: PRK09601 588858005633 YchF GTPase; Region: YchF; cd01900 588858005634 G1 box; other site 588858005635 GTP/Mg2+ binding site [chemical binding]; other site 588858005636 Switch I region; other site 588858005637 G2 box; other site 588858005638 Switch II region; other site 588858005639 G3 box; other site 588858005640 G4 box; other site 588858005641 G5 box; other site 588858005642 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 588858005643 Protein of unknown function (DUF2743); Region: DUF2743; pfam10899 588858005644 Protein of unknown function (DUF4427); Region: DUF4427; pfam14468 588858005645 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 588858005646 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 588858005647 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 588858005648 hydrogenase 1 large subunit; Provisional; Region: PRK10170 588858005649 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 588858005650 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 588858005651 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 588858005652 putative substrate-binding site; other site 588858005653 nickel binding site [ion binding]; other site 588858005654 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 588858005655 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 588858005656 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 588858005657 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 588858005658 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 588858005659 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 588858005660 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 588858005661 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 588858005662 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 588858005663 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 588858005664 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 588858005665 NAD(P) binding site [chemical binding]; other site 588858005666 trehalase; Provisional; Region: treA; PRK13271 588858005667 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 588858005668 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 588858005669 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 588858005670 Flagellar regulator YcgR; Region: YcgR; pfam07317 588858005671 PilZ domain; Region: PilZ; pfam07238 588858005672 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 588858005673 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 588858005674 N-acetyl-D-glucosamine binding site [chemical binding]; other site 588858005675 catalytic residue [active] 588858005676 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 588858005677 dimer interface [polypeptide binding]; other site 588858005678 catalytic triad [active] 588858005679 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 588858005680 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 588858005681 TrkA-C domain; Region: TrkA_C; pfam02080 588858005682 Transporter associated domain; Region: CorC_HlyC; smart01091 588858005683 alanine racemase; Reviewed; Region: dadX; PRK03646 588858005684 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 588858005685 active site 588858005686 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 588858005687 substrate binding site [chemical binding]; other site 588858005688 catalytic residues [active] 588858005689 dimer interface [polypeptide binding]; other site 588858005690 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 588858005691 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 588858005692 SpoVR family protein; Provisional; Region: PRK11767 588858005693 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 588858005694 fatty acid metabolism regulator; Provisional; Region: PRK04984 588858005695 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 588858005696 DNA-binding site [nucleotide binding]; DNA binding site 588858005697 FadR C-terminal domain; Region: FadR_C; pfam07840 588858005698 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 588858005699 transmembrane helices; other site 588858005700 disulfide bond formation protein B; Provisional; Region: PRK01749 588858005701 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 588858005702 GnsA/GnsB family; Region: GnsAB; pfam08178 588858005703 hypothetical protein; Provisional; Region: PRK05170 588858005704 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 588858005705 hypothetical protein; Provisional; Region: PRK10691 588858005706 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 588858005707 septum formation inhibitor; Reviewed; Region: minC; PRK03511 588858005708 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 588858005709 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 588858005710 cell division inhibitor MinD; Provisional; Region: PRK10818 588858005711 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 588858005712 Switch I; other site 588858005713 Switch II; other site 588858005714 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 588858005715 ribonuclease D; Provisional; Region: PRK10829 588858005716 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 588858005717 catalytic site [active] 588858005718 putative active site [active] 588858005719 putative substrate binding site [chemical binding]; other site 588858005720 HRDC domain; Region: HRDC; cl02578 588858005721 Transposase IS200 like; Region: Y1_Tnp; pfam01797 588858005722 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 588858005723 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 588858005724 acyl-activating enzyme (AAE) consensus motif; other site 588858005725 putative AMP binding site [chemical binding]; other site 588858005726 putative active site [active] 588858005727 putative CoA binding site [chemical binding]; other site 588858005728 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 588858005729 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 588858005730 Glycoprotease family; Region: Peptidase_M22; pfam00814 588858005731 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 588858005732 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 588858005733 DEAD_2; Region: DEAD_2; pfam06733 588858005734 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 588858005735 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 588858005736 homotrimer interaction site [polypeptide binding]; other site 588858005737 putative active site [active] 588858005738 hypothetical protein; Provisional; Region: PRK05114 588858005739 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 588858005740 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 588858005741 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 588858005742 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 588858005743 putative active site [active] 588858005744 putative CoA binding site [chemical binding]; other site 588858005745 nudix motif; other site 588858005746 metal binding site [ion binding]; metal-binding site 588858005747 L-serine deaminase; Provisional; Region: PRK15023 588858005748 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 588858005749 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 588858005750 phage resistance protein; Provisional; Region: PRK10551 588858005751 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 588858005752 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 588858005753 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 588858005754 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 588858005755 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 588858005756 Transporter associated domain; Region: CorC_HlyC; smart01091 588858005757 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 588858005758 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 588858005759 active pocket/dimerization site; other site 588858005760 active site 588858005761 phosphorylation site [posttranslational modification] 588858005762 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 588858005763 active site 588858005764 phosphorylation site [posttranslational modification] 588858005765 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 588858005766 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 588858005767 hypothetical protein; Provisional; Region: PRK02913 588858005768 hypothetical protein; Provisional; Region: PRK11469 588858005769 Domain of unknown function DUF; Region: DUF204; pfam02659 588858005770 Domain of unknown function DUF; Region: DUF204; pfam02659 588858005771 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 588858005772 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 588858005773 S-adenosylmethionine binding site [chemical binding]; other site 588858005774 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 588858005775 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 588858005776 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 588858005777 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 588858005778 DNA-binding site [nucleotide binding]; DNA binding site 588858005779 RNA-binding motif; other site 588858005780 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 588858005781 YebO-like protein; Region: YebO; pfam13974 588858005782 PhoPQ regulatory protein; Provisional; Region: PRK10299 588858005783 YobH-like protein; Region: YobH; pfam13996 588858005784 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 588858005785 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 588858005786 dimerization interface [polypeptide binding]; other site 588858005787 putative Zn2+ binding site [ion binding]; other site 588858005788 putative DNA binding site [nucleotide binding]; other site 588858005789 Bacterial transcriptional regulator; Region: IclR; pfam01614 588858005790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858005791 Major Facilitator Superfamily; Region: MFS_1; pfam07690 588858005792 putative substrate translocation pore; other site 588858005793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858005794 heat shock protein HtpX; Provisional; Region: PRK05457 588858005795 carboxy-terminal protease; Provisional; Region: PRK11186 588858005796 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 588858005797 protein binding site [polypeptide binding]; other site 588858005798 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 588858005799 Catalytic dyad [active] 588858005800 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 588858005801 ProP expression regulator; Provisional; Region: PRK04950 588858005802 ProQ/FINO family; Region: ProQ; pfam04352 588858005803 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 588858005804 GAF domain; Region: GAF_2; pfam13185 588858005805 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 588858005806 Paraquat-inducible protein A; Region: PqiA; pfam04403 588858005807 Paraquat-inducible protein A; Region: PqiA; pfam04403 588858005808 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 588858005809 mce related protein; Region: MCE; pfam02470 588858005810 mce related protein; Region: MCE; pfam02470 588858005811 mce related protein; Region: MCE; pfam02470 588858005812 mce related protein; Region: MCE; pfam02470 588858005813 mce related protein; Region: MCE; pfam02470 588858005814 mce related protein; Region: MCE; pfam02470 588858005815 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 588858005816 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 588858005817 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 588858005818 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 588858005819 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 588858005820 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 588858005821 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 588858005822 type III secretion protein SopE2; Provisional; Region: PRK15280 588858005823 Salmonella type III secretion SopE effector N-terminus; Region: SecIII_SopE_N; pfam05364 588858005824 SopE GEF domain; Region: SopE_GEF; pfam07487 588858005825 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 588858005826 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 588858005827 Coenzyme A binding pocket [chemical binding]; other site 588858005828 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 588858005829 MULE transposase domain; Region: MULE; pfam10551 588858005830 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 588858005831 DNA binding site [nucleotide binding] 588858005832 active site 588858005833 Int/Topo IB signature motif; other site 588858005834 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 588858005835 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 588858005836 EamA-like transporter family; Region: EamA; pfam00892 588858005837 EamA-like transporter family; Region: EamA; pfam00892 588858005838 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 588858005839 pseudogene; in-frame stop following codon 23 588858005840 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 588858005841 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 588858005842 ADP-ribose binding site [chemical binding]; other site 588858005843 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 588858005844 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 588858005845 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 588858005846 Predicted chitinase [General function prediction only]; Region: COG3179 588858005847 exonuclease VIII; Reviewed; Region: PRK09709 588858005848 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 588858005849 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 588858005850 dimer interface [polypeptide binding]; other site 588858005851 active site 588858005852 Int/Topo IB signature motif; other site 588858005853 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 588858005854 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 588858005855 hypothetical protein; Provisional; Region: PRK10301 588858005856 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 588858005857 Predicted amidohydrolase [General function prediction only]; Region: COG0388 588858005858 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 588858005859 exodeoxyribonuclease X; Provisional; Region: PRK07983 588858005860 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 588858005861 active site 588858005862 catalytic site [active] 588858005863 substrate binding site [chemical binding]; other site 588858005864 protease 2; Provisional; Region: PRK10115 588858005865 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 588858005866 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 588858005867 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 588858005868 putative metal binding site [ion binding]; other site 588858005869 hypothetical protein; Provisional; Region: PRK13680 588858005870 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 588858005871 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 588858005872 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 588858005873 ATP-grasp domain; Region: ATP-grasp; pfam02222 588858005874 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 588858005875 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 588858005876 active site 588858005877 intersubunit interface [polypeptide binding]; other site 588858005878 catalytic residue [active] 588858005879 phosphogluconate dehydratase; Validated; Region: PRK09054 588858005880 6-phosphogluconate dehydratase; Region: edd; TIGR01196 588858005881 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 588858005882 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 588858005883 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 588858005884 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 588858005885 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 588858005886 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 588858005887 putative active site [active] 588858005888 pyruvate kinase; Provisional; Region: PRK05826 588858005889 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 588858005890 domain interfaces; other site 588858005891 active site 588858005892 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 588858005893 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 588858005894 putative acyl-acceptor binding pocket; other site 588858005895 putative peptidase; Provisional; Region: PRK11649 588858005896 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 588858005897 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 588858005898 Peptidase family M23; Region: Peptidase_M23; pfam01551 588858005899 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 588858005900 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 588858005901 metal binding site [ion binding]; metal-binding site 588858005902 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 588858005903 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 588858005904 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 588858005905 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 588858005906 ABC-ATPase subunit interface; other site 588858005907 dimer interface [polypeptide binding]; other site 588858005908 putative PBP binding regions; other site 588858005909 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 588858005910 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 588858005911 Walker A motif; other site 588858005912 ATP binding site [chemical binding]; other site 588858005913 Walker B motif; other site 588858005914 arginine finger; other site 588858005915 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 588858005916 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 588858005917 RuvA N terminal domain; Region: RuvA_N; pfam01330 588858005918 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 588858005919 putative cytoplasmic protein; disrupted by frameshift 588858005920 hypothetical protein; Provisional; Region: PRK11470 588858005921 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 588858005922 active site 588858005923 putative DNA-binding cleft [nucleotide binding]; other site 588858005924 dimer interface [polypeptide binding]; other site 588858005925 hypothetical protein; Validated; Region: PRK00110 588858005926 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 588858005927 nudix motif; other site 588858005928 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 588858005929 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 588858005930 dimer interface [polypeptide binding]; other site 588858005931 anticodon binding site; other site 588858005932 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 588858005933 homodimer interface [polypeptide binding]; other site 588858005934 motif 1; other site 588858005935 active site 588858005936 motif 2; other site 588858005937 GAD domain; Region: GAD; pfam02938 588858005938 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 588858005939 active site 588858005940 motif 3; other site 588858005941 Isochorismatase family; Region: Isochorismatase; pfam00857 588858005942 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 588858005943 catalytic triad [active] 588858005944 conserved cis-peptide bond; other site 588858005945 hypothetical protein; Provisional; Region: PRK10302 588858005946 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 588858005947 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 588858005948 S-adenosylmethionine binding site [chemical binding]; other site 588858005949 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 588858005950 S-adenosylmethionine binding site [chemical binding]; other site 588858005951 copper homeostasis protein CutC; Provisional; Region: PRK11572 588858005952 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 588858005953 putative metal binding site [ion binding]; other site 588858005954 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 588858005955 arginyl-tRNA synthetase; Region: argS; TIGR00456 588858005956 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 588858005957 active site 588858005958 HIGH motif; other site 588858005959 KMSK motif region; other site 588858005960 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 588858005961 tRNA binding surface [nucleotide binding]; other site 588858005962 anticodon binding site; other site 588858005963 penicillin-binding protein 2; Provisional; Region: PRK10795 588858005964 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 588858005965 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 588858005966 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 588858005967 Flagellar protein FlhE; Region: FlhE; pfam06366 588858005968 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 588858005969 FHIPEP family; Region: FHIPEP; pfam00771 588858005970 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 588858005971 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 588858005972 chemotaxis regulator CheZ; Provisional; Region: PRK11166 588858005973 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 588858005974 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 588858005975 active site 588858005976 phosphorylation site [posttranslational modification] 588858005977 intermolecular recognition site; other site 588858005978 dimerization interface [polypeptide binding]; other site 588858005979 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 588858005980 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 588858005981 active site 588858005982 phosphorylation site [posttranslational modification] 588858005983 intermolecular recognition site; other site 588858005984 dimerization interface [polypeptide binding]; other site 588858005985 CheB methylesterase; Region: CheB_methylest; pfam01339 588858005986 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 588858005987 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 588858005988 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 588858005989 S-adenosylmethionine binding site [chemical binding]; other site 588858005990 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 588858005991 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 588858005992 dimer interface [polypeptide binding]; other site 588858005993 ligand binding site [chemical binding]; other site 588858005994 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 588858005995 dimerization interface [polypeptide binding]; other site 588858005996 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 588858005997 dimer interface [polypeptide binding]; other site 588858005998 putative CheW interface [polypeptide binding]; other site 588858005999 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 588858006000 putative CheA interaction surface; other site 588858006001 chemotaxis protein CheA; Provisional; Region: PRK10547 588858006002 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 588858006003 putative binding surface; other site 588858006004 active site 588858006005 CheY binding; Region: CheY-binding; pfam09078 588858006006 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 588858006007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 588858006008 ATP binding site [chemical binding]; other site 588858006009 Mg2+ binding site [ion binding]; other site 588858006010 G-X-G motif; other site 588858006011 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 588858006012 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 588858006013 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 588858006014 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 588858006015 ligand binding site [chemical binding]; other site 588858006016 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 588858006017 flagellar motor protein MotA; Validated; Region: PRK09110 588858006018 transcriptional activator FlhC; Provisional; Region: PRK12722 588858006019 transcriptional activator FlhD; Provisional; Region: PRK02909 588858006020 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 588858006021 Ligand Binding Site [chemical binding]; other site 588858006022 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 588858006023 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 588858006024 active site 588858006025 homotetramer interface [polypeptide binding]; other site 588858006026 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 588858006027 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 588858006028 pseudogene; frameshift 588858006029 DJ-1 family protein; Region: not_thiJ; TIGR01383 588858006030 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 588858006031 conserved cys residue [active] 588858006032 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 588858006033 Ferritin-like domain; Region: Ferritin; pfam00210 588858006034 ferroxidase diiron center [ion binding]; other site 588858006035 hypothetical protein; Provisional; Region: PRK09273 588858006036 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 588858006037 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 588858006038 YecR-like lipoprotein; Region: YecR; pfam13992 588858006039 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 588858006040 Ferritin-like domain; Region: Ferritin; pfam00210 588858006041 ferroxidase diiron center [ion binding]; other site 588858006042 probable metal-binding protein; Region: matur_matur; TIGR03853 588858006043 tyrosine transporter TyrP; Provisional; Region: PRK15132 588858006044 aromatic amino acid transport protein; Region: araaP; TIGR00837 588858006045 hypothetical protein; Provisional; Region: PRK10396 588858006046 yecA family protein; Region: ygfB_yecA; TIGR02292 588858006047 SEC-C motif; Region: SEC-C; pfam02810 588858006048 glucose-6-phosphate 1-dehydrogenase; Region: PLN02640 588858006049 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 588858006050 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 588858006051 NlpC/P60 family; Region: NLPC_P60; cl17555 588858006052 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 588858006053 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 588858006054 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 588858006055 GIY-YIG motif/motif A; other site 588858006056 active site 588858006057 catalytic site [active] 588858006058 putative DNA binding site [nucleotide binding]; other site 588858006059 metal binding site [ion binding]; metal-binding site 588858006060 UvrB/uvrC motif; Region: UVR; pfam02151 588858006061 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 588858006062 Helix-hairpin-helix motif; Region: HHH; pfam00633 588858006063 response regulator; Provisional; Region: PRK09483 588858006064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 588858006065 active site 588858006066 phosphorylation site [posttranslational modification] 588858006067 intermolecular recognition site; other site 588858006068 dimerization interface [polypeptide binding]; other site 588858006069 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 588858006070 DNA binding residues [nucleotide binding] 588858006071 dimerization interface [polypeptide binding]; other site 588858006072 hypothetical protein; Provisional; Region: PRK10613 588858006073 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 588858006074 Autoinducer binding domain; Region: Autoind_bind; pfam03472 588858006075 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 588858006076 DNA binding residues [nucleotide binding] 588858006077 dimerization interface [polypeptide binding]; other site 588858006078 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 588858006079 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 588858006080 Walker A/P-loop; other site 588858006081 ATP binding site [chemical binding]; other site 588858006082 Q-loop/lid; other site 588858006083 ABC transporter signature motif; other site 588858006084 Walker B; other site 588858006085 D-loop; other site 588858006086 H-loop/switch region; other site 588858006087 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 588858006088 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 588858006089 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858006090 dimer interface [polypeptide binding]; other site 588858006091 conserved gate region; other site 588858006092 putative PBP binding loops; other site 588858006093 ABC-ATPase subunit interface; other site 588858006094 D-cysteine desulfhydrase; Validated; Region: PRK03910 588858006095 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 588858006096 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858006097 catalytic residue [active] 588858006098 cystine transporter subunit; Provisional; Region: PRK11260 588858006099 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 588858006100 substrate binding pocket [chemical binding]; other site 588858006101 membrane-bound complex binding site; other site 588858006102 hinge residues; other site 588858006103 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 588858006104 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 588858006105 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 588858006106 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 588858006107 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 588858006108 DNA binding residues [nucleotide binding] 588858006109 Transposase IS200 like; Region: Y1_Tnp; pfam01797 588858006110 flagellin; Validated; Region: PRK08026 588858006111 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 588858006112 Flagellin D3 domain; Region: Flagellin_D3; pfam08884 588858006113 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 588858006114 flagellar capping protein; Reviewed; Region: fliD; PRK08032 588858006115 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 588858006116 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 588858006117 flagellar protein FliS; Validated; Region: fliS; PRK05685 588858006118 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 588858006119 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 588858006120 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 588858006121 active site 588858006122 Na/Ca binding site [ion binding]; other site 588858006123 catalytic site [active] 588858006124 lipoprotein; Provisional; Region: PRK10397 588858006125 putative inner membrane protein; Provisional; Region: PRK11099 588858006126 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 588858006127 CPxP motif; other site 588858006128 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 588858006129 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 588858006130 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 588858006131 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 588858006132 flagellar motor switch protein FliG; Region: fliG; TIGR00207 588858006133 FliG C-terminal domain; Region: FliG_C; pfam01706 588858006134 flagellar assembly protein H; Validated; Region: fliH; PRK05687 588858006135 Flagellar assembly protein FliH; Region: FliH; pfam02108 588858006136 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 588858006137 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 588858006138 Walker A motif/ATP binding site; other site 588858006139 Walker B motif; other site 588858006140 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 588858006141 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 588858006142 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 588858006143 flagellar hook-length control protein; Provisional; Region: PRK10118 588858006144 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 588858006145 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 588858006146 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 588858006147 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 588858006148 flagellar motor switch protein; Validated; Region: fliN; PRK05698 588858006149 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 588858006150 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 588858006151 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 588858006152 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 588858006153 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 588858006154 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 588858006155 DNA binding residues [nucleotide binding] 588858006156 dimerization interface [polypeptide binding]; other site 588858006157 hypothetical protein; Provisional; Region: PRK10708 588858006158 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 588858006159 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 588858006160 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 588858006161 active site 588858006162 motif I; other site 588858006163 motif II; other site 588858006164 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 588858006165 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 588858006166 metal binding site [ion binding]; metal-binding site 588858006167 active site 588858006168 I-site; other site 588858006169 Uncharacterized small protein [Function unknown]; Region: COG5475 588858006170 hypothetical protein; Provisional; Region: PRK10062 588858006171 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 588858006172 EamA-like transporter family; Region: EamA; pfam00892 588858006173 EamA-like transporter family; Region: EamA; pfam00892 588858006174 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 588858006175 additional DNA contacts [nucleotide binding]; other site 588858006176 mismatch recognition site; other site 588858006177 active site 588858006178 zinc binding site [ion binding]; other site 588858006179 DNA intercalation site [nucleotide binding]; other site 588858006180 DNA cytosine methylase; Provisional; Region: PRK10458 588858006181 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 588858006182 cofactor binding site; other site 588858006183 DNA binding site [nucleotide binding] 588858006184 substrate interaction site [chemical binding]; other site 588858006185 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 588858006186 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 588858006187 Zn2+ binding site [ion binding]; other site 588858006188 Mg2+ binding site [ion binding]; other site 588858006189 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 588858006190 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 588858006191 trimer interface [polypeptide binding]; other site 588858006192 eyelet of channel; other site 588858006193 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 588858006194 DNA-binding site [nucleotide binding]; DNA binding site 588858006195 RNA-binding motif; other site 588858006196 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 588858006197 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 588858006198 active site 588858006199 DNA binding site [nucleotide binding] 588858006200 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 588858006201 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 588858006202 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 588858006203 Catalytic site [active] 588858006204 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 588858006205 DNA-binding interface [nucleotide binding]; DNA binding site 588858006206 type III secretion system protein; Provisional; Region: PRK15383 588858006207 non-LEE encoded effector protein NleB; Provisional; Region: PRK15382 588858006208 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 588858006209 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 588858006210 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 588858006211 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 588858006212 putative baseplate J-like protein; disrupted by frameshift 588858006213 Phage protein GP46; Region: GP46; pfam07409 588858006214 Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; pfam06890 588858006215 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 588858006216 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 588858006217 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 588858006218 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 588858006219 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 588858006220 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 588858006221 Phage tail tube protein; Region: Tail_tube; pfam10618 588858006222 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 588858006223 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 588858006224 Protein of unknown function (DUF2635); Region: DUF2635; pfam10948 588858006225 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 588858006226 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 588858006227 oligomerization interface [polypeptide binding]; other site 588858006228 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 588858006229 Phage capsid family; Region: Phage_capsid; pfam05065 588858006230 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 588858006231 Phage-related protein [Function unknown]; Region: COG4695 588858006232 Phage portal protein; Region: Phage_portal; pfam04860 588858006233 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 588858006234 Phage terminase, small subunit; Region: Terminase_4; pfam05119 588858006235 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 588858006236 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 588858006237 active site 588858006238 potential frameshift: common BLAST hit: gi|339998920|ref|YP_004729803.1| phage protein 588858006239 KilA-N domain; Region: KilA-N; pfam04383 588858006240 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 588858006241 Predicted chitinase [General function prediction only]; Region: COG3179 588858006242 catalytic residue [active] 588858006243 Phage holin family (Lysis protein S); Region: Phage_holin_3; pfam05106 588858006244 Protein of unknown function (DUF968); Region: DUF968; pfam06147 588858006245 KilA-N domain; Region: KilA-N; pfam04383 588858006246 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 588858006247 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 588858006248 PerC transcriptional activator; Region: PerC; pfam06069 588858006249 Helix-turn-helix domain; Region: HTH_36; pfam13730 588858006250 Ash protein family; Region: Phage_ASH; pfam10554 588858006251 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 588858006252 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 588858006253 non-specific DNA binding site [nucleotide binding]; other site 588858006254 salt bridge; other site 588858006255 sequence-specific DNA binding site [nucleotide binding]; other site 588858006256 Predicted transcriptional regulator [Transcription]; Region: COG2932 588858006257 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 588858006258 non-specific DNA binding site [nucleotide binding]; other site 588858006259 salt bridge; other site 588858006260 sequence-specific DNA binding site [nucleotide binding]; other site 588858006261 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 588858006262 Catalytic site [active] 588858006263 Uncharacterized conserved protein (DUF2303); Region: DUF2303; pfam10065 588858006264 HD domain; Region: HD_3; cl17350 588858006265 Protein of unknown function DUF262; Region: DUF262; pfam03235 588858006266 Uncharacterized conserved protein [Function unknown]; Region: COG1479 588858006267 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 588858006268 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 588858006269 active site 588858006270 catalytic site [active] 588858006271 substrate binding site [chemical binding]; other site 588858006272 Domain of unknown function (DUF4224); Region: DUF4224; pfam13986 588858006273 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 588858006274 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 588858006275 dimer interface [polypeptide binding]; other site 588858006276 active site 588858006277 Int/Topo IB signature motif; other site 588858006278 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 588858006279 pseudogene; frameshift 588858006280 putative protease; Region: PHA00666 588858006281 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 588858006282 Integrase; Region: Integrase_1; pfam12835 588858006283 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 588858006284 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 588858006285 Sel1 repeat; Region: Sel1; pfam08238 588858006286 Sel1-like repeats; Region: SEL1; smart00671 588858006287 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 588858006288 AMP nucleosidase; Provisional; Region: PRK08292 588858006289 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 588858006290 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 588858006291 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 588858006292 MATE family multidrug exporter; Provisional; Region: PRK10189 588858006293 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 588858006294 L,D-transpeptidase; Provisional; Region: PRK10190 588858006295 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 588858006296 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 588858006297 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 588858006298 putative dimer interface [polypeptide binding]; other site 588858006299 active site pocket [active] 588858006300 putative cataytic base [active] 588858006301 cobalamin synthase; Reviewed; Region: cobS; PRK00235 588858006302 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 588858006303 homotrimer interface [polypeptide binding]; other site 588858006304 Walker A motif; other site 588858006305 GTP binding site [chemical binding]; other site 588858006306 Walker B motif; other site 588858006307 cobyric acid synthase; Provisional; Region: PRK00784 588858006308 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 588858006309 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 588858006310 catalytic triad [active] 588858006311 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 588858006312 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 588858006313 Walker A/P-loop; other site 588858006314 ATP binding site [chemical binding]; other site 588858006315 Q-loop/lid; other site 588858006316 ABC transporter signature motif; other site 588858006317 Walker B; other site 588858006318 D-loop; other site 588858006319 H-loop/switch region; other site 588858006320 cobalt transport protein CbiQ; Provisional; Region: PRK15485 588858006321 cobalt transport protein CbiN; Provisional; Region: PRK02898 588858006322 cobalt transport protein CbiM; Validated; Region: PRK08319 588858006323 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 588858006324 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 588858006325 active site 588858006326 SAM binding site [chemical binding]; other site 588858006327 homodimer interface [polypeptide binding]; other site 588858006328 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 588858006329 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 588858006330 active site 588858006331 C-terminal domain interface [polypeptide binding]; other site 588858006332 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 588858006333 active site 588858006334 N-terminal domain interface [polypeptide binding]; other site 588858006335 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 588858006336 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 588858006337 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 588858006338 active site 588858006339 SAM binding site [chemical binding]; other site 588858006340 homodimer interface [polypeptide binding]; other site 588858006341 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 588858006342 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 588858006343 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 588858006344 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 588858006345 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 588858006346 active site 588858006347 SAM binding site [chemical binding]; other site 588858006348 homodimer interface [polypeptide binding]; other site 588858006349 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 588858006350 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 588858006351 S-adenosylmethionine binding site [chemical binding]; other site 588858006352 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 588858006353 active site 588858006354 putative homodimer interface [polypeptide binding]; other site 588858006355 SAM binding site [chemical binding]; other site 588858006356 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 588858006357 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 588858006358 Precorrin-8X methylmutase; Region: CbiC; pfam02570 588858006359 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 588858006360 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 588858006361 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 588858006362 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 588858006363 catalytic triad [active] 588858006364 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 588858006365 Sensory domain found in PocR; Region: PocR; pfam10114 588858006366 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 588858006367 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 588858006368 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 588858006369 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 588858006370 amphipathic channel; other site 588858006371 Asn-Pro-Ala signature motifs; other site 588858006372 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 588858006373 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 588858006374 Hexamer interface [polypeptide binding]; other site 588858006375 Putative hexagonal pore residue; other site 588858006376 propanediol utilization protein PduB; Provisional; Region: PRK15415 588858006377 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 588858006378 putative hexamer interface [polypeptide binding]; other site 588858006379 putative hexagonal pore; other site 588858006380 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 588858006381 putative hexamer interface [polypeptide binding]; other site 588858006382 putative hexagonal pore; other site 588858006383 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 588858006384 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 588858006385 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 588858006386 alpha-beta subunit interface [polypeptide binding]; other site 588858006387 alpha-gamma subunit interface [polypeptide binding]; other site 588858006388 active site 588858006389 substrate and K+ binding site; other site 588858006390 K+ binding site [ion binding]; other site 588858006391 cobalamin binding site [chemical binding]; other site 588858006392 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 588858006393 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 588858006394 Cell division protein FtsA; Region: FtsA; cl17206 588858006395 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 588858006396 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 588858006397 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 588858006398 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 588858006399 Hexamer interface [polypeptide binding]; other site 588858006400 Putative hexagonal pore residue; other site 588858006401 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 588858006402 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 588858006403 putative hexamer interface [polypeptide binding]; other site 588858006404 putative hexagonal pore; other site 588858006405 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 588858006406 Propanediol utilisation protein PduL; Region: PduL; pfam06130 588858006407 Propanediol utilisation protein PduL; Region: PduL; pfam06130 588858006408 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 588858006409 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 588858006410 Hexamer/Pentamer interface [polypeptide binding]; other site 588858006411 central pore; other site 588858006412 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 588858006413 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 588858006414 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 588858006415 putative catalytic cysteine [active] 588858006416 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 588858006417 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 588858006418 putative active site [active] 588858006419 metal binding site [ion binding]; metal-binding site 588858006420 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 588858006421 SLBB domain; Region: SLBB; pfam10531 588858006422 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 588858006423 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 588858006424 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 588858006425 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 588858006426 putative hexamer interface [polypeptide binding]; other site 588858006427 putative hexagonal pore; other site 588858006428 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 588858006429 putative hexamer interface [polypeptide binding]; other site 588858006430 putative hexagonal pore; other site 588858006431 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 588858006432 putative hexamer interface [polypeptide binding]; other site 588858006433 putative hexagonal pore; other site 588858006434 Ethanolamine utilisation - propanediol utilisation; Region: PduV-EutP; pfam10662 588858006435 G3 box; other site 588858006436 Switch II region; other site 588858006437 GTP/Mg2+ binding site [chemical binding]; other site 588858006438 G4 box; other site 588858006439 G5 box; other site 588858006440 propionate kinase; Reviewed; Region: PRK12397 588858006441 propionate/acetate kinase; Provisional; Region: PRK12379 588858006442 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 588858006443 hypothetical protein; Provisional; Region: PRK05423 588858006444 Predicted membrane protein [Function unknown]; Region: COG1289 588858006445 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 588858006446 DNA gyrase inhibitor; Provisional; Region: PRK10016 588858006447 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 588858006448 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 588858006449 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 588858006450 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 588858006451 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 588858006452 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 588858006453 4Fe-4S binding domain; Region: Fer4; cl02805 588858006454 thiosulfate reductase PhsA; Provisional; Region: PRK15488 588858006455 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 588858006456 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 588858006457 putative [Fe4-S4] binding site [ion binding]; other site 588858006458 putative molybdopterin cofactor binding site [chemical binding]; other site 588858006459 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 588858006460 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 588858006461 putative molybdopterin cofactor binding site; other site 588858006462 E3 ubiquitin-protein ligase SopA; Provisional; Region: PRK15377 588858006463 SopA-like central domain; Region: SopA; pfam13981 588858006464 SopA-like catalytic domain; Region: SopA_C; pfam13979 588858006465 exonuclease I; Provisional; Region: sbcB; PRK11779 588858006466 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 588858006467 active site 588858006468 catalytic site [active] 588858006469 substrate binding site [chemical binding]; other site 588858006470 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 588858006471 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 588858006472 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 588858006473 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858006474 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 588858006475 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 588858006476 dimerization interface [polypeptide binding]; other site 588858006477 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 588858006478 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 588858006479 putative NAD(P) binding site [chemical binding]; other site 588858006480 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 588858006481 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 588858006482 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 588858006483 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 588858006484 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 588858006485 NAD binding site [chemical binding]; other site 588858006486 dimerization interface [polypeptide binding]; other site 588858006487 product binding site; other site 588858006488 substrate binding site [chemical binding]; other site 588858006489 zinc binding site [ion binding]; other site 588858006490 catalytic residues [active] 588858006491 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 588858006492 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 588858006493 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858006494 homodimer interface [polypeptide binding]; other site 588858006495 catalytic residue [active] 588858006496 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 588858006497 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 588858006498 active site 588858006499 motif I; other site 588858006500 motif II; other site 588858006501 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 588858006502 putative active site pocket [active] 588858006503 4-fold oligomerization interface [polypeptide binding]; other site 588858006504 metal binding residues [ion binding]; metal-binding site 588858006505 3-fold/trimer interface [polypeptide binding]; other site 588858006506 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 588858006507 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 588858006508 putative active site [active] 588858006509 oxyanion strand; other site 588858006510 catalytic triad [active] 588858006511 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 588858006512 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 588858006513 catalytic residues [active] 588858006514 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 588858006515 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 588858006516 substrate binding site [chemical binding]; other site 588858006517 glutamase interaction surface [polypeptide binding]; other site 588858006518 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 588858006519 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 588858006520 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 588858006521 metal binding site [ion binding]; metal-binding site 588858006522 chain length determinant protein WzzB; Provisional; Region: PRK15471 588858006523 Chain length determinant protein; Region: Wzz; pfam02706 588858006524 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 588858006525 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 588858006526 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 588858006527 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 588858006528 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 588858006529 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 588858006530 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 588858006531 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 588858006532 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 588858006533 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 588858006534 Bacterial sugar transferase; Region: Bac_transf; pfam02397 588858006535 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 588858006536 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 588858006537 active site 588858006538 substrate binding site [chemical binding]; other site 588858006539 metal binding site [ion binding]; metal-binding site 588858006540 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 588858006541 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 588858006542 Substrate binding site; other site 588858006543 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 588858006544 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 588858006545 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 588858006546 active site 588858006547 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 588858006548 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 588858006549 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 588858006550 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 588858006551 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 588858006552 active site 588858006553 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 588858006554 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 588858006555 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 588858006556 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 588858006557 NAD(P) binding site [chemical binding]; other site 588858006558 active site 588858006559 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 588858006560 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 588858006561 inhibitor-cofactor binding pocket; inhibition site 588858006562 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858006563 catalytic residue [active] 588858006564 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 588858006565 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 588858006566 NAD binding site [chemical binding]; other site 588858006567 homotetramer interface [polypeptide binding]; other site 588858006568 homodimer interface [polypeptide binding]; other site 588858006569 substrate binding site [chemical binding]; other site 588858006570 active site 588858006571 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 588858006572 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 588858006573 substrate binding site; other site 588858006574 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 588858006575 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 588858006576 catalytic loop [active] 588858006577 iron binding site [ion binding]; other site 588858006578 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 588858006579 FAD binding pocket [chemical binding]; other site 588858006580 FAD binding motif [chemical binding]; other site 588858006581 phosphate binding motif [ion binding]; other site 588858006582 beta-alpha-beta structure motif; other site 588858006583 NAD binding pocket [chemical binding]; other site 588858006584 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 588858006585 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 588858006586 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 588858006587 substrate binding site; other site 588858006588 tetramer interface; other site 588858006589 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 588858006590 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 588858006591 NADP binding site [chemical binding]; other site 588858006592 active site 588858006593 putative substrate binding site [chemical binding]; other site 588858006594 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 588858006595 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 588858006596 NAD binding site [chemical binding]; other site 588858006597 substrate binding site [chemical binding]; other site 588858006598 homodimer interface [polypeptide binding]; other site 588858006599 active site 588858006600 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 588858006601 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 588858006602 active site 588858006603 tetramer interface; other site 588858006604 colanic acid biosynthesis protein WcaM; Region: WcaM; TIGR04004 588858006605 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 588858006606 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 588858006607 putative ADP-binding pocket [chemical binding]; other site 588858006608 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 588858006609 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 588858006610 colanic acid exporter; Provisional; Region: PRK10459 588858006611 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 588858006612 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 588858006613 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 588858006614 phosphomannomutase CpsG; Provisional; Region: PRK15414 588858006615 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 588858006616 active site 588858006617 substrate binding site [chemical binding]; other site 588858006618 metal binding site [ion binding]; metal-binding site 588858006619 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 588858006620 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 588858006621 Substrate binding site; other site 588858006622 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 588858006623 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 588858006624 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 588858006625 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 588858006626 active site 588858006627 GDP-Mannose binding site [chemical binding]; other site 588858006628 dimer interface [polypeptide binding]; other site 588858006629 modified nudix motif 588858006630 metal binding site [ion binding]; metal-binding site 588858006631 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 588858006632 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 588858006633 NADP binding site [chemical binding]; other site 588858006634 active site 588858006635 putative substrate binding site [chemical binding]; other site 588858006636 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 588858006637 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 588858006638 NADP-binding site; other site 588858006639 homotetramer interface [polypeptide binding]; other site 588858006640 substrate binding site [chemical binding]; other site 588858006641 homodimer interface [polypeptide binding]; other site 588858006642 active site 588858006643 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 588858006644 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 588858006645 putative trimer interface [polypeptide binding]; other site 588858006646 putative active site [active] 588858006647 putative substrate binding site [chemical binding]; other site 588858006648 putative CoA binding site [chemical binding]; other site 588858006649 putative glycosyl transferase; Provisional; Region: PRK10063 588858006650 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 588858006651 metal-binding site 588858006652 putative colanic acid biosynthesis protein; Provisional; Region: wcaD; cl08075 588858006653 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 588858006654 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 588858006655 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 588858006656 putative acyl transferase; Provisional; Region: PRK10191 588858006657 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 588858006658 trimer interface [polypeptide binding]; other site 588858006659 active site 588858006660 substrate binding site [chemical binding]; other site 588858006661 CoA binding site [chemical binding]; other site 588858006662 putative glycosyl transferase; Provisional; Region: PRK10018 588858006663 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 588858006664 active site 588858006665 tyrosine kinase; Provisional; Region: PRK11519 588858006666 Chain length determinant protein; Region: Wzz; pfam02706 588858006667 Chain length determinant protein; Region: Wzz; cl15801 588858006668 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 588858006669 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 588858006670 Low molecular weight phosphatase family; Region: LMWPc; cd00115 588858006671 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 588858006672 active site 588858006673 polysaccharide export protein Wza; Provisional; Region: PRK15078 588858006674 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 588858006675 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 588858006676 FOG: CBS domain [General function prediction only]; Region: COG0517 588858006677 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 588858006678 Transporter associated domain; Region: CorC_HlyC; smart01091 588858006679 putative assembly protein; Provisional; Region: PRK10833 588858006680 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 588858006681 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 588858006682 trimer interface [polypeptide binding]; other site 588858006683 active site 588858006684 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 588858006685 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 588858006686 ATP-binding site [chemical binding]; other site 588858006687 Sugar specificity; other site 588858006688 Pyrimidine base specificity; other site 588858006689 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 588858006690 PAS domain S-box; Region: sensory_box; TIGR00229 588858006691 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 588858006692 putative active site [active] 588858006693 heme pocket [chemical binding]; other site 588858006694 PAS domain S-box; Region: sensory_box; TIGR00229 588858006695 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 588858006696 putative active site [active] 588858006697 heme pocket [chemical binding]; other site 588858006698 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 588858006699 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 588858006700 metal binding site [ion binding]; metal-binding site 588858006701 active site 588858006702 I-site; other site 588858006703 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 588858006704 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 588858006705 AlkA N-terminal domain; Region: AlkA_N; pfam06029 588858006706 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 588858006707 minor groove reading motif; other site 588858006708 helix-hairpin-helix signature motif; other site 588858006709 substrate binding pocket [chemical binding]; other site 588858006710 active site 588858006711 putative chaperone; Provisional; Region: PRK11678 588858006712 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 588858006713 nucleotide binding site [chemical binding]; other site 588858006714 putative NEF/HSP70 interaction site [polypeptide binding]; other site 588858006715 SBD interface [polypeptide binding]; other site 588858006716 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 588858006717 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 588858006718 HlyD family secretion protein; Region: HlyD_3; pfam13437 588858006719 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 588858006720 Protein export membrane protein; Region: SecD_SecF; cl14618 588858006721 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 588858006722 putative transporter; Provisional; Region: PRK10504 588858006723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858006724 putative substrate translocation pore; other site 588858006725 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 588858006726 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 588858006727 dimerization interface [polypeptide binding]; other site 588858006728 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 588858006729 dimer interface [polypeptide binding]; other site 588858006730 phosphorylation site [posttranslational modification] 588858006731 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 588858006732 ATP binding site [chemical binding]; other site 588858006733 Mg2+ binding site [ion binding]; other site 588858006734 G-X-G motif; other site 588858006735 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 588858006736 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 588858006737 active site 588858006738 phosphorylation site [posttranslational modification] 588858006739 intermolecular recognition site; other site 588858006740 dimerization interface [polypeptide binding]; other site 588858006741 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 588858006742 DNA binding site [nucleotide binding] 588858006743 pseudogene; frameshift 588858006744 PcfJ-like protein; Region: PcfJ; pfam14284 588858006745 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 588858006746 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 588858006747 putative protease; Provisional; Region: PRK15452 588858006748 Peptidase family U32; Region: Peptidase_U32; pfam01136 588858006749 putative cytoplasmic protein; disrupted by frameshift 588858006750 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 588858006751 lipid kinase; Reviewed; Region: PRK13054 588858006752 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 588858006753 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 588858006754 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 588858006755 putative active site; other site 588858006756 catalytic residue [active] 588858006757 nucleoside transporter; Region: 2A0110; TIGR00889 588858006758 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858006759 putative substrate translocation pore; other site 588858006760 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 588858006761 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 588858006762 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 588858006763 substrate binding site [chemical binding]; other site 588858006764 ATP binding site [chemical binding]; other site 588858006765 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 588858006766 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 588858006767 DNA-binding site [nucleotide binding]; DNA binding site 588858006768 UTRA domain; Region: UTRA; pfam07702 588858006769 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 588858006770 dimer interface [polypeptide binding]; other site 588858006771 substrate binding site [chemical binding]; other site 588858006772 ATP binding site [chemical binding]; other site 588858006773 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 588858006774 substrate binding site [chemical binding]; other site 588858006775 multimerization interface [polypeptide binding]; other site 588858006776 ATP binding site [chemical binding]; other site 588858006777 Predicted integral membrane protein [Function unknown]; Region: COG5455 588858006778 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 588858006779 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 588858006780 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 588858006781 PapC N-terminal domain; Region: PapC_N; pfam13954 588858006782 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 588858006783 PapC C-terminal domain; Region: PapC_C; pfam13953 588858006784 fimbrial chaperone protein PegB; Provisional; Region: PRK15218 588858006785 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 588858006786 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 588858006787 fimbrial chaperone protein; Provisional; Region: PRK15220 588858006788 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 588858006789 antiporter inner membrane protein; Provisional; Region: PRK11670 588858006790 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 588858006791 Walker A motif; other site 588858006792 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 588858006793 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 588858006794 active site 588858006795 HIGH motif; other site 588858006796 KMSKS motif; other site 588858006797 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 588858006798 tRNA binding surface [nucleotide binding]; other site 588858006799 anticodon binding site; other site 588858006800 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 588858006801 dimer interface [polypeptide binding]; other site 588858006802 putative tRNA-binding site [nucleotide binding]; other site 588858006803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 588858006804 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 588858006805 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 588858006806 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 588858006807 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 588858006808 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 588858006809 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 588858006810 active site 588858006811 phosphorylation site [posttranslational modification] 588858006812 intermolecular recognition site; other site 588858006813 dimerization interface [polypeptide binding]; other site 588858006814 LytTr DNA-binding domain; Region: LytTR; pfam04397 588858006815 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 588858006816 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 588858006817 GAF domain; Region: GAF; pfam01590 588858006818 Histidine kinase; Region: His_kinase; pfam06580 588858006819 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 588858006820 ATP binding site [chemical binding]; other site 588858006821 Mg2+ binding site [ion binding]; other site 588858006822 G-X-G motif; other site 588858006823 transcriptional regulator MirA; Provisional; Region: PRK15043 588858006824 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 588858006825 DNA binding residues [nucleotide binding] 588858006826 hypothetical protein; Provisional; Region: PRK13681 588858006827 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 588858006828 putative PBP binding loops; other site 588858006829 ABC-ATPase subunit interface; other site 588858006830 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 588858006831 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 588858006832 Walker A/P-loop; other site 588858006833 ATP binding site [chemical binding]; other site 588858006834 Q-loop/lid; other site 588858006835 ABC transporter signature motif; other site 588858006836 Walker B; other site 588858006837 D-loop; other site 588858006838 H-loop/switch region; other site 588858006839 CBS domain; Region: CBS; pfam00571 588858006840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858006841 dimer interface [polypeptide binding]; other site 588858006842 conserved gate region; other site 588858006843 ABC-ATPase subunit interface; other site 588858006844 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 588858006845 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 588858006846 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 588858006847 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 588858006848 D-lactate dehydrogenase; Provisional; Region: PRK11183 588858006849 FAD binding domain; Region: FAD_binding_4; pfam01565 588858006850 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 588858006851 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 588858006852 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 588858006853 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 588858006854 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 588858006855 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 588858006856 oxidoreductase; Provisional; Region: PRK12743 588858006857 classical (c) SDRs; Region: SDR_c; cd05233 588858006858 NAD(P) binding site [chemical binding]; other site 588858006859 active site 588858006860 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 588858006861 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 588858006862 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 588858006863 FMN binding site [chemical binding]; other site 588858006864 active site 588858006865 catalytic residues [active] 588858006866 substrate binding site [chemical binding]; other site 588858006867 salicylate hydroxylase; Provisional; Region: PRK08163 588858006868 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 588858006869 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 588858006870 maleylacetoacetate isomerase; Region: maiA; TIGR01262 588858006871 C-terminal domain interface [polypeptide binding]; other site 588858006872 GSH binding site (G-site) [chemical binding]; other site 588858006873 putative dimer interface [polypeptide binding]; other site 588858006874 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 588858006875 dimer interface [polypeptide binding]; other site 588858006876 N-terminal domain interface [polypeptide binding]; other site 588858006877 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 588858006878 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 588858006879 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 588858006880 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 588858006881 Cupin domain; Region: Cupin_2; pfam07883 588858006882 Cupin domain; Region: Cupin_2; pfam07883 588858006883 benzoate transport; Region: 2A0115; TIGR00895 588858006884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858006885 putative substrate translocation pore; other site 588858006886 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 588858006887 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858006888 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 588858006889 dimerization interface [polypeptide binding]; other site 588858006890 hypothetical protein; Provisional; Region: PRK01821 588858006891 hypothetical protein; Provisional; Region: PRK10711 588858006892 cytidine deaminase; Provisional; Region: PRK09027 588858006893 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 588858006894 active site 588858006895 catalytic motif [active] 588858006896 Zn binding site [ion binding]; other site 588858006897 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 588858006898 active site 588858006899 catalytic motif [active] 588858006900 Zn binding site [ion binding]; other site 588858006901 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 588858006902 putative active site [active] 588858006903 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 588858006904 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 588858006905 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 588858006906 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 588858006907 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 588858006908 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 588858006909 homodimer interface [polypeptide binding]; other site 588858006910 active site 588858006911 FMN binding site [chemical binding]; other site 588858006912 substrate binding site [chemical binding]; other site 588858006913 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 588858006914 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 588858006915 TM-ABC transporter signature motif; other site 588858006916 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 588858006917 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 588858006918 Walker A/P-loop; other site 588858006919 ATP binding site [chemical binding]; other site 588858006920 Q-loop/lid; other site 588858006921 ABC transporter signature motif; other site 588858006922 Walker B; other site 588858006923 D-loop; other site 588858006924 H-loop/switch region; other site 588858006925 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 588858006926 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 588858006927 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 588858006928 ligand binding site [chemical binding]; other site 588858006929 calcium binding site [ion binding]; other site 588858006930 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 588858006931 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 588858006932 DNA binding site [nucleotide binding] 588858006933 domain linker motif; other site 588858006934 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 588858006935 dimerization interface (closed form) [polypeptide binding]; other site 588858006936 ligand binding site [chemical binding]; other site 588858006937 Predicted membrane protein [Function unknown]; Region: COG2311 588858006938 hypothetical protein; Provisional; Region: PRK10835 588858006939 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 588858006940 GTP cyclohydrolase I; Provisional; Region: PLN03044 588858006941 active site 588858006942 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 588858006943 S-formylglutathione hydrolase; Region: PLN02442 588858006944 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 588858006945 non-specific DNA binding site [nucleotide binding]; other site 588858006946 salt bridge; other site 588858006947 sequence-specific DNA binding site [nucleotide binding]; other site 588858006948 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 588858006949 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 588858006950 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 588858006951 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 588858006952 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 588858006953 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 588858006954 motif II; other site 588858006955 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 588858006956 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858006957 putative substrate translocation pore; other site 588858006958 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 588858006959 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 588858006960 N-terminal plug; other site 588858006961 ligand-binding site [chemical binding]; other site 588858006962 lysine transporter; Provisional; Region: PRK10836 588858006963 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 588858006964 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858006965 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 588858006966 putative dimerization interface [polypeptide binding]; other site 588858006967 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 588858006968 endonuclease IV; Provisional; Region: PRK01060 588858006969 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 588858006970 AP (apurinic/apyrimidinic) site pocket; other site 588858006971 DNA interaction; other site 588858006972 Metal-binding active site; metal-binding site 588858006973 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 588858006974 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 588858006975 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 588858006976 active site 588858006977 P-loop; other site 588858006978 phosphorylation site [posttranslational modification] 588858006979 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 588858006980 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 588858006981 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 588858006982 putative substrate binding site [chemical binding]; other site 588858006983 putative ATP binding site [chemical binding]; other site 588858006984 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 588858006985 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 588858006986 active site 588858006987 phosphorylation site [posttranslational modification] 588858006988 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 588858006989 dimerization domain swap beta strand [polypeptide binding]; other site 588858006990 regulatory protein interface [polypeptide binding]; other site 588858006991 active site 588858006992 regulatory phosphorylation site [posttranslational modification]; other site 588858006993 sugar efflux transporter B; Provisional; Region: PRK15011 588858006994 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858006995 putative substrate translocation pore; other site 588858006996 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 588858006997 Flagellin N-methylase; Region: FliB; cl00497 588858006998 contains frameshifts 588858006999 elongation factor P; Provisional; Region: PRK04542 588858007000 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 588858007001 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 588858007002 RNA binding site [nucleotide binding]; other site 588858007003 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 588858007004 RNA binding site [nucleotide binding]; other site 588858007005 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 588858007006 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 588858007007 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 588858007008 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 588858007009 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 588858007010 active site 588858007011 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 588858007012 NlpC/P60 family; Region: NLPC_P60; pfam00877 588858007013 phage resistance protein; Provisional; Region: PRK10551 588858007014 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 588858007015 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 588858007016 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 588858007017 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 588858007018 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 588858007019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858007020 dimer interface [polypeptide binding]; other site 588858007021 conserved gate region; other site 588858007022 putative PBP binding loops; other site 588858007023 ABC-ATPase subunit interface; other site 588858007024 microcin C ABC transporter permease; Provisional; Region: PRK15021 588858007025 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858007026 dimer interface [polypeptide binding]; other site 588858007027 conserved gate region; other site 588858007028 ABC-ATPase subunit interface; other site 588858007029 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 588858007030 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 588858007031 Walker A/P-loop; other site 588858007032 ATP binding site [chemical binding]; other site 588858007033 Q-loop/lid; other site 588858007034 ABC transporter signature motif; other site 588858007035 Walker B; other site 588858007036 D-loop; other site 588858007037 H-loop/switch region; other site 588858007038 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 588858007039 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 588858007040 Walker A/P-loop; other site 588858007041 ATP binding site [chemical binding]; other site 588858007042 Q-loop/lid; other site 588858007043 ABC transporter signature motif; other site 588858007044 Walker B; other site 588858007045 D-loop; other site 588858007046 H-loop/switch region; other site 588858007047 hypothetical protein; Provisional; Region: PRK11835 588858007048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858007049 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 588858007050 putative substrate translocation pore; other site 588858007051 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 588858007052 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 588858007053 RNA binding surface [nucleotide binding]; other site 588858007054 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 588858007055 active site 588858007056 uracil binding [chemical binding]; other site 588858007057 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 588858007058 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 588858007059 ATP binding site [chemical binding]; other site 588858007060 putative Mg++ binding site [ion binding]; other site 588858007061 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 588858007062 nucleotide binding region [chemical binding]; other site 588858007063 ATP-binding site [chemical binding]; other site 588858007064 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 588858007065 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 588858007066 5S rRNA interface [nucleotide binding]; other site 588858007067 CTC domain interface [polypeptide binding]; other site 588858007068 L16 interface [polypeptide binding]; other site 588858007069 Nucleoid-associated protein [General function prediction only]; Region: COG3081 588858007070 nucleoid-associated protein NdpA; Validated; Region: PRK00378 588858007071 hypothetical protein; Provisional; Region: PRK13689 588858007072 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 588858007073 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 588858007074 Sulfatase; Region: Sulfatase; cl17466 588858007075 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 588858007076 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 588858007077 Catalytic site [active] 588858007078 DinI-like family; Region: DinI; cl11630 588858007079 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 588858007080 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 588858007081 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 588858007082 Phage T4 tail fibre; Region: Phage_T4_gp36; pfam03903 588858007083 Phage head maturation protease [General function prediction only]; Region: COG3740 588858007084 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 588858007085 Phage-related protein [Function unknown]; Region: COG4695; cl01923 588858007086 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 588858007087 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 588858007088 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 588858007089 Protein of unknown function (DUF968); Region: DUF968; pfam06147 588858007090 E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387 588858007091 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 588858007092 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 588858007093 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 588858007094 Leucine-rich repeats; other site 588858007095 Substrate binding site [chemical binding]; other site 588858007096 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 588858007097 DinI-like family; Region: DinI; cl11630 588858007098 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 588858007099 transcriptional regulator NarP; Provisional; Region: PRK10403 588858007100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 588858007101 active site 588858007102 phosphorylation site [posttranslational modification] 588858007103 intermolecular recognition site; other site 588858007104 dimerization interface [polypeptide binding]; other site 588858007105 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 588858007106 DNA binding residues [nucleotide binding] 588858007107 dimerization interface [polypeptide binding]; other site 588858007108 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 588858007109 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 588858007110 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 588858007111 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 588858007112 catalytic residues [active] 588858007113 central insert; other site 588858007114 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 588858007115 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150 588858007116 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 588858007117 heme exporter protein CcmC; Region: ccmC; TIGR01191 588858007118 heme exporter protein CcmB; Region: ccmB; TIGR01190 588858007119 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 588858007120 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 588858007121 Walker A/P-loop; other site 588858007122 ATP binding site [chemical binding]; other site 588858007123 Q-loop/lid; other site 588858007124 ABC transporter signature motif; other site 588858007125 Walker B; other site 588858007126 D-loop; other site 588858007127 H-loop/switch region; other site 588858007128 cytochrome c-type protein NapC; Provisional; Region: PRK10617 588858007129 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 588858007130 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 588858007131 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 588858007132 4Fe-4S binding domain; Region: Fer4_5; pfam12801 588858007133 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 588858007134 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 588858007135 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 588858007136 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 588858007137 [4Fe-4S] binding site [ion binding]; other site 588858007138 molybdopterin cofactor binding site; other site 588858007139 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 588858007140 molybdopterin cofactor binding site; other site 588858007141 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 588858007142 ferredoxin-type protein; Provisional; Region: PRK10194 588858007143 4Fe-4S binding domain; Region: Fer4; cl02805 588858007144 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 588858007145 secondary substrate binding site; other site 588858007146 primary substrate binding site; other site 588858007147 inhibition loop; other site 588858007148 dimerization interface [polypeptide binding]; other site 588858007149 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 588858007150 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 588858007151 Walker A/P-loop; other site 588858007152 ATP binding site [chemical binding]; other site 588858007153 Q-loop/lid; other site 588858007154 ABC transporter signature motif; other site 588858007155 Walker B; other site 588858007156 D-loop; other site 588858007157 H-loop/switch region; other site 588858007158 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 588858007159 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 588858007160 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 588858007161 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 588858007162 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 588858007163 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 588858007164 DNA binding site [nucleotide binding] 588858007165 active site 588858007166 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 588858007167 ApbE family; Region: ApbE; pfam02424 588858007168 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 588858007169 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 588858007170 trimer interface [polypeptide binding]; other site 588858007171 eyelet of channel; other site 588858007172 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 588858007173 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 588858007174 ATP binding site [chemical binding]; other site 588858007175 G-X-G motif; other site 588858007176 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 588858007177 putative binding surface; other site 588858007178 active site 588858007179 transcriptional regulator RcsB; Provisional; Region: PRK10840 588858007180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 588858007181 active site 588858007182 phosphorylation site [posttranslational modification] 588858007183 intermolecular recognition site; other site 588858007184 dimerization interface [polypeptide binding]; other site 588858007185 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 588858007186 DNA binding residues [nucleotide binding] 588858007187 dimerization interface [polypeptide binding]; other site 588858007188 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 588858007189 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 588858007190 dimer interface [polypeptide binding]; other site 588858007191 phosphorylation site [posttranslational modification] 588858007192 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 588858007193 ATP binding site [chemical binding]; other site 588858007194 Mg2+ binding site [ion binding]; other site 588858007195 G-X-G motif; other site 588858007196 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 588858007197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 588858007198 active site 588858007199 phosphorylation site [posttranslational modification] 588858007200 intermolecular recognition site; other site 588858007201 dimerization interface [polypeptide binding]; other site 588858007202 DNA gyrase subunit A; Validated; Region: PRK05560 588858007203 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 588858007204 CAP-like domain; other site 588858007205 active site 588858007206 primary dimer interface [polypeptide binding]; other site 588858007207 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 588858007208 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 588858007209 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 588858007210 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 588858007211 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 588858007212 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 588858007213 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 588858007214 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 588858007215 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 588858007216 active site pocket [active] 588858007217 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 588858007218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858007219 putative substrate translocation pore; other site 588858007220 Transcriptional regulators [Transcription]; Region: GntR; COG1802 588858007221 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 588858007222 DNA-binding site [nucleotide binding]; DNA binding site 588858007223 FCD domain; Region: FCD; pfam07729 588858007224 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 588858007225 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 588858007226 S-adenosylmethionine binding site [chemical binding]; other site 588858007227 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 588858007228 ATP cone domain; Region: ATP-cone; pfam03477 588858007229 Class I ribonucleotide reductase; Region: RNR_I; cd01679 588858007230 active site 588858007231 dimer interface [polypeptide binding]; other site 588858007232 catalytic residues [active] 588858007233 effector binding site; other site 588858007234 R2 peptide binding site; other site 588858007235 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 588858007236 dimer interface [polypeptide binding]; other site 588858007237 putative radical transfer pathway; other site 588858007238 diiron center [ion binding]; other site 588858007239 tyrosyl radical; other site 588858007240 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 588858007241 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 588858007242 catalytic loop [active] 588858007243 iron binding site [ion binding]; other site 588858007244 Major Facilitator Superfamily; Region: MFS_1; pfam07690 588858007245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858007246 putative substrate translocation pore; other site 588858007247 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 588858007248 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858007249 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 588858007250 dimerization interface [polypeptide binding]; other site 588858007251 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 588858007252 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 588858007253 active site 588858007254 catalytic site [active] 588858007255 metal binding site [ion binding]; metal-binding site 588858007256 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 588858007257 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858007258 putative substrate translocation pore; other site 588858007259 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 588858007260 hydroxyglutarate oxidase; Provisional; Region: PRK11728 588858007261 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 588858007262 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 588858007263 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 588858007264 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 588858007265 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 588858007266 Cysteine-rich domain; Region: CCG; pfam02754 588858007267 Cysteine-rich domain; Region: CCG; pfam02754 588858007268 deubiquitinase SseL; Provisional; Region: PRK14848 588858007269 hypothetical protein; Provisional; Region: PRK03673 588858007270 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 588858007271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858007272 D-galactonate transporter; Region: 2A0114; TIGR00893 588858007273 putative substrate translocation pore; other site 588858007274 L-rhamnonate dehydratase; Provisional; Region: PRK15440 588858007275 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 588858007276 putative active site pocket [active] 588858007277 putative metal binding site [ion binding]; other site 588858007278 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 588858007279 Transcriptional regulator [Transcription]; Region: IclR; COG1414 588858007280 Bacterial transcriptional regulator; Region: IclR; pfam01614 588858007281 hypothetical protein; Provisional; Region: PRK03673 588858007282 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 588858007283 putative MPT binding site; other site 588858007284 Competence-damaged protein; Region: CinA; cl00666 588858007285 YfaZ precursor; Region: YfaZ; pfam07437 588858007286 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 588858007287 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 588858007288 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 588858007289 catalytic core [active] 588858007290 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 588858007291 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 588858007292 inhibitor-cofactor binding pocket; inhibition site 588858007293 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858007294 catalytic residue [active] 588858007295 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 588858007296 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 588858007297 Ligand binding site; other site 588858007298 Putative Catalytic site; other site 588858007299 DXD motif; other site 588858007300 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 588858007301 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 588858007302 active site 588858007303 substrate binding site [chemical binding]; other site 588858007304 cosubstrate binding site; other site 588858007305 catalytic site [active] 588858007306 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 588858007307 active site 588858007308 hexamer interface [polypeptide binding]; other site 588858007309 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 588858007310 NAD binding site [chemical binding]; other site 588858007311 substrate binding site [chemical binding]; other site 588858007312 active site 588858007313 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 588858007314 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 588858007315 putative active site [active] 588858007316 putative catalytic site [active] 588858007317 putative Zn binding site [ion binding]; other site 588858007318 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 588858007319 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 588858007320 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 588858007321 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 588858007322 signal transduction protein PmrD; Provisional; Region: PRK15450 588858007323 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 588858007324 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 588858007325 acyl-activating enzyme (AAE) consensus motif; other site 588858007326 putative AMP binding site [chemical binding]; other site 588858007327 putative active site [active] 588858007328 putative CoA binding site [chemical binding]; other site 588858007329 O-succinylbenzoate synthase [Coenzyme metabolism]; Region: MenC; COG1441 588858007330 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 588858007331 active site 588858007332 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 588858007333 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 588858007334 substrate binding site [chemical binding]; other site 588858007335 oxyanion hole (OAH) forming residues; other site 588858007336 trimer interface [polypeptide binding]; other site 588858007337 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 588858007338 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 588858007339 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 588858007340 dimer interface [polypeptide binding]; other site 588858007341 tetramer interface [polypeptide binding]; other site 588858007342 PYR/PP interface [polypeptide binding]; other site 588858007343 TPP binding site [chemical binding]; other site 588858007344 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 588858007345 TPP-binding site; other site 588858007346 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 588858007347 isochorismate synthases; Region: isochor_syn; TIGR00543 588858007348 hypothetical protein; Provisional; Region: PRK10404 588858007349 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 588858007350 Coenzyme A binding pocket [chemical binding]; other site 588858007351 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; disrupted by frameshift 588858007352 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 588858007353 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 588858007354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 588858007355 active site 588858007356 phosphorylation site [posttranslational modification] 588858007357 intermolecular recognition site; other site 588858007358 dimerization interface [polypeptide binding]; other site 588858007359 von Willebrand factor; Region: vWF_A; pfam12450 588858007360 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 588858007361 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 588858007362 metal ion-dependent adhesion site (MIDAS); other site 588858007363 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 588858007364 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 588858007365 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 588858007366 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 588858007367 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 588858007368 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 588858007369 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 588858007370 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 588858007371 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 588858007372 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 588858007373 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 588858007374 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 588858007375 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 588858007376 4Fe-4S binding domain; Region: Fer4; pfam00037 588858007377 4Fe-4S binding domain; Region: Fer4; pfam00037 588858007378 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 588858007379 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 588858007380 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 588858007381 catalytic loop [active] 588858007382 iron binding site [ion binding]; other site 588858007383 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 588858007384 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 588858007385 [4Fe-4S] binding site [ion binding]; other site 588858007386 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 588858007387 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 588858007388 SLBB domain; Region: SLBB; pfam10531 588858007389 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 588858007390 NADH dehydrogenase subunit E; Validated; Region: PRK07539 588858007391 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 588858007392 putative dimer interface [polypeptide binding]; other site 588858007393 [2Fe-2S] cluster binding site [ion binding]; other site 588858007394 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 588858007395 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 588858007396 NADH dehydrogenase subunit D; Validated; Region: PRK06075 588858007397 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 588858007398 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 588858007399 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 588858007400 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858007401 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 588858007402 putative dimerization interface [polypeptide binding]; other site 588858007403 aminotransferase AlaT; Validated; Region: PRK09265 588858007404 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 588858007405 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858007406 homodimer interface [polypeptide binding]; other site 588858007407 catalytic residue [active] 588858007408 5'-nucleotidase; Provisional; Region: PRK03826 588858007409 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 588858007410 transmembrane helices; other site 588858007411 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 588858007412 TrkA-C domain; Region: TrkA_C; pfam02080 588858007413 TrkA-C domain; Region: TrkA_C; pfam02080 588858007414 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 588858007415 putative phosphatase; Provisional; Region: PRK11587 588858007416 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 588858007417 motif II; other site 588858007418 hypothetical protein; Validated; Region: PRK05445 588858007419 hypothetical protein; Provisional; Region: PRK01816 588858007420 propionate/acetate kinase; Provisional; Region: PRK12379 588858007421 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 588858007422 phosphate acetyltransferase; Reviewed; Region: PRK05632 588858007423 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 588858007424 DRTGG domain; Region: DRTGG; pfam07085 588858007425 phosphate acetyltransferase; Region: pta; TIGR00651 588858007426 hypothetical protein; Provisional; Region: PRK11588 588858007427 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 588858007428 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 588858007429 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 588858007430 PYR/PP interface [polypeptide binding]; other site 588858007431 dimer interface [polypeptide binding]; other site 588858007432 TPP binding site [chemical binding]; other site 588858007433 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 588858007434 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 588858007435 TPP-binding site [chemical binding]; other site 588858007436 dimer interface [polypeptide binding]; other site 588858007437 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK12996 588858007438 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 588858007439 active site 588858007440 P-loop; other site 588858007441 phosphorylation site [posttranslational modification] 588858007442 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 588858007443 active site 588858007444 phosphorylation site [posttranslational modification] 588858007445 Transcriptional regulators [Transcription]; Region: PurR; COG1609 588858007446 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 588858007447 DNA binding site [nucleotide binding] 588858007448 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 588858007449 putative dimerization interface [polypeptide binding]; other site 588858007450 putative ligand binding site [chemical binding]; other site 588858007451 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 588858007452 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 588858007453 nudix motif; other site 588858007454 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 588858007455 active site 588858007456 metal binding site [ion binding]; metal-binding site 588858007457 homotetramer interface [polypeptide binding]; other site 588858007458 glutathione S-transferase; Provisional; Region: PRK15113 588858007459 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 588858007460 C-terminal domain interface [polypeptide binding]; other site 588858007461 GSH binding site (G-site) [chemical binding]; other site 588858007462 dimer interface [polypeptide binding]; other site 588858007463 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 588858007464 N-terminal domain interface [polypeptide binding]; other site 588858007465 putative dimer interface [polypeptide binding]; other site 588858007466 putative substrate binding pocket (H-site) [chemical binding]; other site 588858007467 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 588858007468 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 588858007469 C-terminal domain interface [polypeptide binding]; other site 588858007470 GSH binding site (G-site) [chemical binding]; other site 588858007471 dimer interface [polypeptide binding]; other site 588858007472 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 588858007473 N-terminal domain interface [polypeptide binding]; other site 588858007474 putative dimer interface [polypeptide binding]; other site 588858007475 active site 588858007476 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 588858007477 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 588858007478 putative NAD(P) binding site [chemical binding]; other site 588858007479 putative active site [active] 588858007480 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 588858007481 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 588858007482 Walker A/P-loop; other site 588858007483 ATP binding site [chemical binding]; other site 588858007484 Q-loop/lid; other site 588858007485 ABC transporter signature motif; other site 588858007486 Walker B; other site 588858007487 D-loop; other site 588858007488 H-loop/switch region; other site 588858007489 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 588858007490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858007491 dimer interface [polypeptide binding]; other site 588858007492 conserved gate region; other site 588858007493 putative PBP binding loops; other site 588858007494 ABC-ATPase subunit interface; other site 588858007495 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 588858007496 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858007497 dimer interface [polypeptide binding]; other site 588858007498 conserved gate region; other site 588858007499 putative PBP binding loops; other site 588858007500 ABC-ATPase subunit interface; other site 588858007501 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 588858007502 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 588858007503 substrate binding pocket [chemical binding]; other site 588858007504 membrane-bound complex binding site; other site 588858007505 hinge residues; other site 588858007506 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 588858007507 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 588858007508 substrate binding pocket [chemical binding]; other site 588858007509 membrane-bound complex binding site; other site 588858007510 hinge residues; other site 588858007511 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 588858007512 Flavoprotein; Region: Flavoprotein; pfam02441 588858007513 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 588858007514 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 588858007515 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 588858007516 dimer interface [polypeptide binding]; other site 588858007517 active site 588858007518 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 588858007519 substrate binding site [chemical binding]; other site 588858007520 catalytic residue [active] 588858007521 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 588858007522 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 588858007523 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 588858007524 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 588858007525 catalytic residue [active] 588858007526 PAS fold; Region: PAS_4; pfam08448 588858007527 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 588858007528 putative active site [active] 588858007529 heme pocket [chemical binding]; other site 588858007530 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 588858007531 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 588858007532 Walker A motif; other site 588858007533 ATP binding site [chemical binding]; other site 588858007534 Walker B motif; other site 588858007535 arginine finger; other site 588858007536 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 588858007537 amidophosphoribosyltransferase; Provisional; Region: PRK09246 588858007538 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 588858007539 active site 588858007540 tetramer interface [polypeptide binding]; other site 588858007541 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 588858007542 active site 588858007543 colicin V production protein; Provisional; Region: PRK10845 588858007544 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 588858007545 cell division protein DedD; Provisional; Region: PRK11633 588858007546 Sporulation related domain; Region: SPOR; pfam05036 588858007547 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 588858007548 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 588858007549 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 588858007550 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 588858007551 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 588858007552 hypothetical protein; Provisional; Region: PRK10847 588858007553 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 588858007554 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 588858007555 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 588858007556 dimerization interface 3.5A [polypeptide binding]; other site 588858007557 active site 588858007558 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 588858007559 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 588858007560 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 588858007561 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 588858007562 ligand binding site [chemical binding]; other site 588858007563 NAD binding site [chemical binding]; other site 588858007564 catalytic site [active] 588858007565 homodimer interface [polypeptide binding]; other site 588858007566 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 588858007567 putative transporter; Provisional; Region: PRK12382 588858007568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858007569 putative substrate translocation pore; other site 588858007570 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 588858007571 non-specific DNA binding site [nucleotide binding]; other site 588858007572 salt bridge; other site 588858007573 sequence-specific DNA binding site [nucleotide binding]; other site 588858007574 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 588858007575 CAAX protease self-immunity; Region: Abi; pfam02517 588858007576 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 588858007577 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 588858007578 dimer interface [polypeptide binding]; other site 588858007579 active site 588858007580 Uncharacterized conserved protein [Function unknown]; Region: COG4121 588858007581 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 588858007582 YfcL protein; Region: YfcL; pfam08891 588858007583 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 588858007584 hypothetical protein; Provisional; Region: PRK10621 588858007585 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 588858007586 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 588858007587 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 588858007588 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 588858007589 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 588858007590 Tetramer interface [polypeptide binding]; other site 588858007591 active site 588858007592 FMN-binding site [chemical binding]; other site 588858007593 HemK family putative methylases; Region: hemK_fam; TIGR00536 588858007594 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 588858007595 S-adenosylmethionine binding site [chemical binding]; other site 588858007596 hypothetical protein; Provisional; Region: PRK04946 588858007597 Smr domain; Region: Smr; pfam01713 588858007598 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 588858007599 catalytic core [active] 588858007600 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 588858007601 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 588858007602 substrate binding site [chemical binding]; other site 588858007603 oxyanion hole (OAH) forming residues; other site 588858007604 trimer interface [polypeptide binding]; other site 588858007605 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 588858007606 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 588858007607 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 588858007608 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 588858007609 dimer interface [polypeptide binding]; other site 588858007610 active site 588858007611 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 588858007612 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 588858007613 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 588858007614 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 588858007615 outer membrane protease; Reviewed; Region: PRK10993 588858007616 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 588858007617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 588858007618 active site 588858007619 phosphorylation site [posttranslational modification] 588858007620 intermolecular recognition site; other site 588858007621 dimerization interface [polypeptide binding]; other site 588858007622 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 588858007623 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 588858007624 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 588858007625 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 588858007626 dimerization interface [polypeptide binding]; other site 588858007627 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 588858007628 dimer interface [polypeptide binding]; other site 588858007629 phosphorylation site [posttranslational modification] 588858007630 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 588858007631 ATP binding site [chemical binding]; other site 588858007632 Mg2+ binding site [ion binding]; other site 588858007633 G-X-G motif; other site 588858007634 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 588858007635 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 588858007636 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 588858007637 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858007638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858007639 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 588858007640 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 588858007641 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 588858007642 putative acyl-acceptor binding pocket; other site 588858007643 aminotransferase; Validated; Region: PRK08175 588858007644 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 588858007645 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858007646 homodimer interface [polypeptide binding]; other site 588858007647 catalytic residue [active] 588858007648 glucokinase; Provisional; Region: glk; PRK00292 588858007649 glucokinase, proteobacterial type; Region: glk; TIGR00749 588858007650 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 588858007651 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 588858007652 Cl- selectivity filter; other site 588858007653 Cl- binding residues [ion binding]; other site 588858007654 pore gating glutamate residue; other site 588858007655 dimer interface [polypeptide binding]; other site 588858007656 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 588858007657 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 588858007658 dimer interface [polypeptide binding]; other site 588858007659 PYR/PP interface [polypeptide binding]; other site 588858007660 TPP binding site [chemical binding]; other site 588858007661 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 588858007662 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 588858007663 TPP-binding site [chemical binding]; other site 588858007664 dimer interface [polypeptide binding]; other site 588858007665 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 588858007666 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 588858007667 active site 588858007668 catalytic tetrad [active] 588858007669 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 588858007670 manganese transport protein MntH; Reviewed; Region: PRK00701 588858007671 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 588858007672 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 588858007673 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 588858007674 Nucleoside recognition; Region: Gate; pfam07670 588858007675 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 588858007676 MASE1; Region: MASE1; pfam05231 588858007677 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 588858007678 diguanylate cyclase; Region: GGDEF; smart00267 588858007679 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 588858007680 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 588858007681 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 588858007682 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 588858007683 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 588858007684 active site 588858007685 HIGH motif; other site 588858007686 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 588858007687 active site 588858007688 KMSKS motif; other site 588858007689 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 588858007690 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858007691 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 588858007692 putative dimerization interface [polypeptide binding]; other site 588858007693 putative substrate binding pocket [chemical binding]; other site 588858007694 XapX domain; Region: XapX; TIGR03510 588858007695 nucleoside transporter; Region: 2A0110; TIGR00889 588858007696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858007697 putative substrate translocation pore; other site 588858007698 purine nucleoside phosphorylase; Provisional; Region: PRK08202 588858007699 hypothetical protein; Provisional; Region: PRK11528 588858007700 Transcriptional regulator [Transcription]; Region: LysR; COG0583 588858007701 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858007702 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 588858007703 putative dimerization interface [polypeptide binding]; other site 588858007704 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 588858007705 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 588858007706 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 588858007707 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 588858007708 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 588858007709 nucleotide binding pocket [chemical binding]; other site 588858007710 K-X-D-G motif; other site 588858007711 catalytic site [active] 588858007712 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 588858007713 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 588858007714 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 588858007715 Dimer interface [polypeptide binding]; other site 588858007716 BRCT sequence motif; other site 588858007717 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 588858007718 cell division protein ZipA; Provisional; Region: PRK03427 588858007719 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 588858007720 FtsZ protein binding site [polypeptide binding]; other site 588858007721 putative sulfate transport protein CysZ; Validated; Region: PRK04949 588858007722 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 588858007723 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 588858007724 dimer interface [polypeptide binding]; other site 588858007725 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858007726 catalytic residue [active] 588858007727 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 588858007728 dimerization domain swap beta strand [polypeptide binding]; other site 588858007729 regulatory protein interface [polypeptide binding]; other site 588858007730 active site 588858007731 regulatory phosphorylation site [posttranslational modification]; other site 588858007732 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 588858007733 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 588858007734 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 588858007735 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 588858007736 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 588858007737 HPr interaction site; other site 588858007738 glycerol kinase (GK) interaction site [polypeptide binding]; other site 588858007739 active site 588858007740 phosphorylation site [posttranslational modification] 588858007741 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 588858007742 dimer interface [polypeptide binding]; other site 588858007743 pyridoxamine kinase; Validated; Region: PRK05756 588858007744 pyridoxal binding site [chemical binding]; other site 588858007745 ATP binding site [chemical binding]; other site 588858007746 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 588858007747 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 588858007748 DNA-binding site [nucleotide binding]; DNA binding site 588858007749 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 588858007750 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858007751 homodimer interface [polypeptide binding]; other site 588858007752 catalytic residue [active] 588858007753 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 588858007754 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 588858007755 catalytic triad [active] 588858007756 hypothetical protein; Provisional; Region: PRK10318 588858007757 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 588858007758 Transglycosylase; Region: Transgly; cl17702 588858007759 cysteine synthase B; Region: cysM; TIGR01138 588858007760 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 588858007761 dimer interface [polypeptide binding]; other site 588858007762 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858007763 catalytic residue [active] 588858007764 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 588858007765 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 588858007766 Walker A/P-loop; other site 588858007767 ATP binding site [chemical binding]; other site 588858007768 Q-loop/lid; other site 588858007769 ABC transporter signature motif; other site 588858007770 Walker B; other site 588858007771 D-loop; other site 588858007772 H-loop/switch region; other site 588858007773 TOBE-like domain; Region: TOBE_3; pfam12857 588858007774 sulfate transport protein; Provisional; Region: cysT; CHL00187 588858007775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858007776 dimer interface [polypeptide binding]; other site 588858007777 conserved gate region; other site 588858007778 putative PBP binding loops; other site 588858007779 ABC-ATPase subunit interface; other site 588858007780 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 588858007781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858007782 dimer interface [polypeptide binding]; other site 588858007783 conserved gate region; other site 588858007784 putative PBP binding loops; other site 588858007785 ABC-ATPase subunit interface; other site 588858007786 thiosulfate transporter subunit; Provisional; Region: PRK10852 588858007787 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 588858007788 short chain dehydrogenase; Provisional; Region: PRK08226 588858007789 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 588858007790 NAD binding site [chemical binding]; other site 588858007791 homotetramer interface [polypeptide binding]; other site 588858007792 homodimer interface [polypeptide binding]; other site 588858007793 active site 588858007794 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 588858007795 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 588858007796 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 588858007797 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 588858007798 putative acetyltransferase; Provisional; Region: PRK03624 588858007799 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 588858007800 Coenzyme A binding pocket [chemical binding]; other site 588858007801 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 588858007802 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 588858007803 active site 588858007804 metal binding site [ion binding]; metal-binding site 588858007805 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 588858007806 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 588858007807 transcriptional regulator EutR; Provisional; Region: PRK10130 588858007808 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 588858007809 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 588858007810 carboxysome structural protein EutK; Provisional; Region: PRK15466 588858007811 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 588858007812 Hexamer interface [polypeptide binding]; other site 588858007813 Hexagonal pore residue; other site 588858007814 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 588858007815 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 588858007816 putative hexamer interface [polypeptide binding]; other site 588858007817 putative hexagonal pore; other site 588858007818 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 588858007819 putative hexamer interface [polypeptide binding]; other site 588858007820 putative hexagonal pore; other site 588858007821 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 588858007822 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 588858007823 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 588858007824 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 588858007825 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 588858007826 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 588858007827 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 588858007828 active site 588858007829 metal binding site [ion binding]; metal-binding site 588858007830 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 588858007831 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 588858007832 nucleotide binding site [chemical binding]; other site 588858007833 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 588858007834 putative catalytic cysteine [active] 588858007835 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 588858007836 Hexamer/Pentamer interface [polypeptide binding]; other site 588858007837 central pore; other site 588858007838 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 588858007839 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 588858007840 Hexamer interface [polypeptide binding]; other site 588858007841 Putative hexagonal pore residue; other site 588858007842 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 588858007843 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 588858007844 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 588858007845 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 588858007846 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 588858007847 G1 box; other site 588858007848 GTP/Mg2+ binding site [chemical binding]; other site 588858007849 G2 box; other site 588858007850 Switch I region; other site 588858007851 G3 box; other site 588858007852 Switch II region; other site 588858007853 G4 box; other site 588858007854 G5 box; other site 588858007855 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 588858007856 putative hexamer interface [polypeptide binding]; other site 588858007857 putative hexagonal pore; other site 588858007858 Transposase IS200 like; Region: Y1_Tnp; pfam01797 588858007859 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 588858007860 Malic enzyme, N-terminal domain; Region: malic; pfam00390 588858007861 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 588858007862 putative NAD(P) binding site [chemical binding]; other site 588858007863 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 588858007864 transaldolase-like protein; Provisional; Region: PTZ00411 588858007865 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 588858007866 active site 588858007867 dimer interface [polypeptide binding]; other site 588858007868 catalytic residue [active] 588858007869 transketolase; Reviewed; Region: PRK12753 588858007870 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 588858007871 TPP-binding site [chemical binding]; other site 588858007872 dimer interface [polypeptide binding]; other site 588858007873 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 588858007874 PYR/PP interface [polypeptide binding]; other site 588858007875 dimer interface [polypeptide binding]; other site 588858007876 TPP binding site [chemical binding]; other site 588858007877 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 588858007878 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 588858007879 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 588858007880 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 588858007881 dimer interface [polypeptide binding]; other site 588858007882 ADP-ribose binding site [chemical binding]; other site 588858007883 active site 588858007884 nudix motif; other site 588858007885 metal binding site [ion binding]; metal-binding site 588858007886 putative periplasmic esterase; Provisional; Region: PRK03642 588858007887 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 588858007888 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 588858007889 4Fe-4S binding domain; Region: Fer4; pfam00037 588858007890 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 588858007891 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 588858007892 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 588858007893 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 588858007894 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 588858007895 dimerization interface [polypeptide binding]; other site 588858007896 Histidine kinase; Region: HisKA_3; pfam07730 588858007897 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 588858007898 ATP binding site [chemical binding]; other site 588858007899 Mg2+ binding site [ion binding]; other site 588858007900 G-X-G motif; other site 588858007901 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 588858007902 Protein export membrane protein; Region: SecD_SecF; cl14618 588858007903 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 588858007904 ArsC family; Region: ArsC; pfam03960 588858007905 putative catalytic residues [active] 588858007906 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 588858007907 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 588858007908 metal binding site [ion binding]; metal-binding site 588858007909 dimer interface [polypeptide binding]; other site 588858007910 hypothetical protein; Provisional; Region: PRK13664 588858007911 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 588858007912 Helicase; Region: Helicase_RecD; pfam05127 588858007913 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 588858007914 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 588858007915 Predicted metalloprotease [General function prediction only]; Region: COG2321 588858007916 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 588858007917 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 588858007918 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 588858007919 ATP binding site [chemical binding]; other site 588858007920 active site 588858007921 substrate binding site [chemical binding]; other site 588858007922 lipoprotein; Provisional; Region: PRK11679 588858007923 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 588858007924 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 588858007925 dihydrodipicolinate synthase; Region: dapA; TIGR00674 588858007926 dimer interface [polypeptide binding]; other site 588858007927 active site 588858007928 catalytic residue [active] 588858007929 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 588858007930 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 588858007931 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 588858007932 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 588858007933 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 588858007934 catalytic triad [active] 588858007935 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 588858007936 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 588858007937 Domain of unknown function DUF20; Region: UPF0118; pfam01594 588858007938 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 588858007939 Peptidase family M48; Region: Peptidase_M48; cl12018 588858007940 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 588858007941 ArsC family; Region: ArsC; pfam03960 588858007942 catalytic residues [active] 588858007943 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 588858007944 DNA replication initiation factor; Provisional; Region: PRK08084 588858007945 uracil transporter; Provisional; Region: PRK10720 588858007946 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 588858007947 active site 588858007948 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 588858007949 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 588858007950 dimerization interface [polypeptide binding]; other site 588858007951 putative ATP binding site [chemical binding]; other site 588858007952 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 588858007953 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 588858007954 active site 588858007955 substrate binding site [chemical binding]; other site 588858007956 cosubstrate binding site; other site 588858007957 catalytic site [active] 588858007958 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 588858007959 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 588858007960 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 588858007961 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 588858007962 putative active site [active] 588858007963 catalytic site [active] 588858007964 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 588858007965 domain interface [polypeptide binding]; other site 588858007966 active site 588858007967 catalytic site [active] 588858007968 exopolyphosphatase; Provisional; Region: PRK10854 588858007969 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 588858007970 nucleotide binding site [chemical binding]; other site 588858007971 MASE1; Region: MASE1; pfam05231 588858007972 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 588858007973 diguanylate cyclase; Region: GGDEF; smart00267 588858007974 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 588858007975 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 588858007976 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 588858007977 Integrase core domain; Region: rve; pfam00665 588858007978 GMP synthase; Reviewed; Region: guaA; PRK00074 588858007979 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 588858007980 AMP/PPi binding site [chemical binding]; other site 588858007981 candidate oxyanion hole; other site 588858007982 catalytic triad [active] 588858007983 potential glutamine specificity residues [chemical binding]; other site 588858007984 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 588858007985 ATP Binding subdomain [chemical binding]; other site 588858007986 Ligand Binding sites [chemical binding]; other site 588858007987 Dimerization subdomain; other site 588858007988 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 588858007989 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 588858007990 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 588858007991 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 588858007992 active site 588858007993 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 588858007994 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 588858007995 generic binding surface II; other site 588858007996 generic binding surface I; other site 588858007997 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 588858007998 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 588858007999 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 588858008000 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 588858008001 Autotransporter beta-domain; Region: Autotransporter; smart00869 588858008002 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 588858008003 putative outer membrane protein; disrupted by frameshift 588858008004 outer membrane protein RatA; Provisional; Region: PRK15315 588858008005 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 588858008006 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 588858008007 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 588858008008 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 588858008009 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 588858008010 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 588858008011 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 588858008012 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 588858008013 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 588858008014 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 588858008015 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 588858008016 intimin-like protein SinH; Provisional; Region: PRK15318 588858008017 intimin-like protein SinH; Provisional; Region: PRK15318 588858008018 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 588858008019 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 588858008020 GTP-binding protein Der; Reviewed; Region: PRK00093 588858008021 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 588858008022 G1 box; other site 588858008023 GTP/Mg2+ binding site [chemical binding]; other site 588858008024 Switch I region; other site 588858008025 G2 box; other site 588858008026 Switch II region; other site 588858008027 G3 box; other site 588858008028 G4 box; other site 588858008029 G5 box; other site 588858008030 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 588858008031 G1 box; other site 588858008032 GTP/Mg2+ binding site [chemical binding]; other site 588858008033 Switch I region; other site 588858008034 G2 box; other site 588858008035 G3 box; other site 588858008036 Switch II region; other site 588858008037 G4 box; other site 588858008038 G5 box; other site 588858008039 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 588858008040 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 588858008041 Trp docking motif [polypeptide binding]; other site 588858008042 active site 588858008043 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 588858008044 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 588858008045 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 588858008046 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 588858008047 dimer interface [polypeptide binding]; other site 588858008048 motif 1; other site 588858008049 active site 588858008050 motif 2; other site 588858008051 motif 3; other site 588858008052 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 588858008053 anticodon binding site; other site 588858008054 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 588858008055 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 588858008056 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 588858008057 cytoskeletal protein RodZ; Provisional; Region: PRK10856 588858008058 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 588858008059 non-specific DNA binding site [nucleotide binding]; other site 588858008060 salt bridge; other site 588858008061 sequence-specific DNA binding site [nucleotide binding]; other site 588858008062 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 588858008063 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 588858008064 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 588858008065 FeS/SAM binding site; other site 588858008066 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 588858008067 active site 588858008068 multimer interface [polypeptide binding]; other site 588858008069 4Fe-4S binding domain; Region: Fer4; pfam00037 588858008070 hydrogenase 4 subunit H; Validated; Region: PRK08222 588858008071 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 588858008072 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 588858008073 4Fe-4S binding domain; Region: Fer4; pfam00037 588858008074 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 588858008075 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 588858008076 putative [Fe4-S4] binding site [ion binding]; other site 588858008077 putative molybdopterin cofactor binding site [chemical binding]; other site 588858008078 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 588858008079 putative molybdopterin cofactor binding site; other site 588858008080 penicillin-binding protein 1C; Provisional; Region: PRK11240 588858008081 Transglycosylase; Region: Transgly; pfam00912 588858008082 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 588858008083 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 588858008084 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 588858008085 MG2 domain; Region: A2M_N; pfam01835 588858008086 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 588858008087 surface patch; other site 588858008088 thioester region; other site 588858008089 specificity defining residues; other site 588858008090 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 588858008091 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 588858008092 active site residue [active] 588858008093 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 588858008094 active site residue [active] 588858008095 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 588858008096 aminopeptidase B; Provisional; Region: PRK05015 588858008097 Peptidase; Region: DUF3663; pfam12404 588858008098 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 588858008099 interface (dimer of trimers) [polypeptide binding]; other site 588858008100 Substrate-binding/catalytic site; other site 588858008101 Zn-binding sites [ion binding]; other site 588858008102 hypothetical protein; Provisional; Region: PRK10721 588858008103 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 588858008104 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 588858008105 catalytic loop [active] 588858008106 iron binding site [ion binding]; other site 588858008107 chaperone protein HscA; Provisional; Region: hscA; PRK05183 588858008108 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 588858008109 nucleotide binding site [chemical binding]; other site 588858008110 putative NEF/HSP70 interaction site [polypeptide binding]; other site 588858008111 SBD interface [polypeptide binding]; other site 588858008112 co-chaperone HscB; Provisional; Region: hscB; PRK05014 588858008113 DnaJ domain; Region: DnaJ; pfam00226 588858008114 HSP70 interaction site [polypeptide binding]; other site 588858008115 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 588858008116 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 588858008117 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 588858008118 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 588858008119 trimerization site [polypeptide binding]; other site 588858008120 active site 588858008121 cysteine desulfurase; Provisional; Region: PRK14012 588858008122 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 588858008123 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 588858008124 catalytic residue [active] 588858008125 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 588858008126 Rrf2 family protein; Region: rrf2_super; TIGR00738 588858008127 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 588858008128 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 588858008129 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 588858008130 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 588858008131 active site 588858008132 dimerization interface [polypeptide binding]; other site 588858008133 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 588858008134 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 588858008135 sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910 588858008136 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 588858008137 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 588858008138 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 588858008139 FAD binding pocket [chemical binding]; other site 588858008140 FAD binding motif [chemical binding]; other site 588858008141 phosphate binding motif [ion binding]; other site 588858008142 beta-alpha-beta structure motif; other site 588858008143 NAD binding pocket [chemical binding]; other site 588858008144 Iron coordination center [ion binding]; other site 588858008145 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 588858008146 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 588858008147 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 588858008148 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 588858008149 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 588858008150 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 588858008151 PRD domain; Region: PRD; pfam00874 588858008152 PRD domain; Region: PRD; pfam00874 588858008153 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 588858008154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858008155 putative substrate translocation pore; other site 588858008156 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 588858008157 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 588858008158 dimer interface [polypeptide binding]; other site 588858008159 active site 588858008160 glycine-pyridoxal phosphate binding site [chemical binding]; other site 588858008161 folate binding site [chemical binding]; other site 588858008162 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 588858008163 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 588858008164 heme-binding site [chemical binding]; other site 588858008165 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 588858008166 FAD binding pocket [chemical binding]; other site 588858008167 FAD binding motif [chemical binding]; other site 588858008168 phosphate binding motif [ion binding]; other site 588858008169 beta-alpha-beta structure motif; other site 588858008170 NAD binding pocket [chemical binding]; other site 588858008171 Heme binding pocket [chemical binding]; other site 588858008172 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 588858008173 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 588858008174 DNA binding site [nucleotide binding] 588858008175 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 588858008176 lysine decarboxylase CadA; Provisional; Region: PRK15400 588858008177 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 588858008178 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 588858008179 homodimer interface [polypeptide binding]; other site 588858008180 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858008181 catalytic residue [active] 588858008182 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 588858008183 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 588858008184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858008185 putative substrate translocation pore; other site 588858008186 POT family; Region: PTR2; pfam00854 588858008187 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 588858008188 Nitrogen regulatory protein P-II; Region: P-II; smart00938 588858008189 response regulator GlrR; Provisional; Region: PRK15115 588858008190 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 588858008191 active site 588858008192 phosphorylation site [posttranslational modification] 588858008193 intermolecular recognition site; other site 588858008194 dimerization interface [polypeptide binding]; other site 588858008195 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 588858008196 Walker A motif; other site 588858008197 ATP binding site [chemical binding]; other site 588858008198 Walker B motif; other site 588858008199 arginine finger; other site 588858008200 hypothetical protein; Provisional; Region: PRK10722 588858008201 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 588858008202 HAMP domain; Region: HAMP; pfam00672 588858008203 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 588858008204 dimer interface [polypeptide binding]; other site 588858008205 phosphorylation site [posttranslational modification] 588858008206 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 588858008207 ATP binding site [chemical binding]; other site 588858008208 Mg2+ binding site [ion binding]; other site 588858008209 G-X-G motif; other site 588858008210 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 588858008211 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 588858008212 dimerization interface [polypeptide binding]; other site 588858008213 ATP binding site [chemical binding]; other site 588858008214 Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of...; Region: PurL; cd02193 588858008215 dimerization interface [polypeptide binding]; other site 588858008216 ATP binding site [chemical binding]; other site 588858008217 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 588858008218 putative active site [active] 588858008219 catalytic triad [active] 588858008220 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 588858008221 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 588858008222 substrate binding pocket [chemical binding]; other site 588858008223 membrane-bound complex binding site; other site 588858008224 hinge residues; other site 588858008225 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 588858008226 N-acetyl-D-glucosamine binding site [chemical binding]; other site 588858008227 catalytic residue [active] 588858008228 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 588858008229 nucleoside/Zn binding site; other site 588858008230 dimer interface [polypeptide binding]; other site 588858008231 catalytic motif [active] 588858008232 hypothetical protein; Provisional; Region: PRK11590 588858008233 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 588858008234 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 588858008235 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 588858008236 active site turn [active] 588858008237 phosphorylation site [posttranslational modification] 588858008238 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 588858008239 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 588858008240 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 588858008241 putative active site [active] 588858008242 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 588858008243 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 588858008244 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 588858008245 putative active site [active] 588858008246 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 588858008247 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 588858008248 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 588858008249 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 588858008250 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858008251 putative substrate translocation pore; other site 588858008252 Transcriptional regulator [Transcription]; Region: LysR; COG0583 588858008253 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858008254 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 588858008255 dimerization interface [polypeptide binding]; other site 588858008256 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 588858008257 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 588858008258 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 588858008259 active site 588858008260 hydrophilic channel; other site 588858008261 dimerization interface [polypeptide binding]; other site 588858008262 catalytic residues [active] 588858008263 active site lid [active] 588858008264 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 588858008265 Recombination protein O N terminal; Region: RecO_N; pfam11967 588858008266 Recombination protein O C terminal; Region: RecO_C; pfam02565 588858008267 GTPase Era; Reviewed; Region: era; PRK00089 588858008268 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 588858008269 G1 box; other site 588858008270 GTP/Mg2+ binding site [chemical binding]; other site 588858008271 Switch I region; other site 588858008272 G2 box; other site 588858008273 Switch II region; other site 588858008274 G3 box; other site 588858008275 G4 box; other site 588858008276 G5 box; other site 588858008277 KH domain; Region: KH_2; pfam07650 588858008278 ribonuclease III; Reviewed; Region: rnc; PRK00102 588858008279 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 588858008280 dimerization interface [polypeptide binding]; other site 588858008281 active site 588858008282 metal binding site [ion binding]; metal-binding site 588858008283 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 588858008284 dsRNA binding site [nucleotide binding]; other site 588858008285 signal peptidase I; Provisional; Region: PRK10861 588858008286 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 588858008287 Catalytic site [active] 588858008288 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 588858008289 GTP-binding protein LepA; Provisional; Region: PRK05433 588858008290 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 588858008291 G1 box; other site 588858008292 putative GEF interaction site [polypeptide binding]; other site 588858008293 GTP/Mg2+ binding site [chemical binding]; other site 588858008294 Switch I region; other site 588858008295 G2 box; other site 588858008296 G3 box; other site 588858008297 Switch II region; other site 588858008298 G4 box; other site 588858008299 G5 box; other site 588858008300 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 588858008301 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 588858008302 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 588858008303 type III secretion protein GogB; Provisional; Region: PRK15386 588858008304 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 588858008305 Macro domain, Appr-1"-pase family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase; cd02900 588858008306 ADP-ribose binding site [chemical binding]; other site 588858008307 putative active site [active] 588858008308 dimer interface [polypeptide binding]; other site 588858008309 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 588858008310 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 588858008311 Phage Tail Collar Domain; Region: Collar; pfam07484 588858008312 Phage-related protein, tail component [Function unknown]; Region: COG4733 588858008313 Putative phage tail protein; Region: Phage-tail_3; pfam13550 588858008314 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 588858008315 Interdomain contacts; other site 588858008316 Cytokine receptor motif; other site 588858008317 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 588858008318 Fibronectin type III protein; Region: DUF3672; pfam12421 588858008319 Phage-related protein, tail component [Function unknown]; Region: COG4723 588858008320 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 588858008321 MPN+ (JAMM) motif; other site 588858008322 Zinc-binding site [ion binding]; other site 588858008323 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 588858008324 NlpC/P60 family; Region: NLPC_P60; cl17555 588858008325 Phage-related protein [Function unknown]; Region: gp18; COG4672 588858008326 Phage-related protein [Function unknown]; Region: COG4718 588858008327 Phage-related minor tail protein [Function unknown]; Region: COG5281 588858008328 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 588858008329 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 588858008330 Minor tail protein T; Region: Phage_tail_T; pfam06223 588858008331 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 588858008332 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 588858008333 Phage tail protein; Region: Phage_tail_3; pfam08813 588858008334 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 588858008335 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 588858008336 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 588858008337 Probable transposase; Region: OrfB_IS605; pfam01385 588858008338 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 588858008339 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 588858008340 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; cl05094 588858008341 similar to DNA packaging protein gp9 of phage N14; disrupted by frameshift 588858008342 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 588858008343 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 588858008344 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 588858008345 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 588858008346 tandem repeat interface [polypeptide binding]; other site 588858008347 oligomer interface [polypeptide binding]; other site 588858008348 active site residues [active] 588858008349 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 588858008350 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 588858008351 gpW; Region: gpW; pfam02831 588858008352 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 588858008353 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 588858008354 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 588858008355 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 588858008356 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 588858008357 catalytic residues [active] 588858008358 phage holin, lambda family; Region: holin_lambda; TIGR01594 588858008359 PipA protein; Region: PipA; pfam07108 588858008360 ORF6N domain; Region: ORF6N; pfam10543 588858008361 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 588858008362 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 588858008363 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 588858008364 DinI-like family; Region: DinI; pfam06183 588858008365 Protein of unknown function (DUF550); Region: DUF550; pfam04447 588858008366 Replication protein P; Region: Phage_lambda_P; pfam06992 588858008367 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 588858008368 Bacteriophage CII protein; Region: Phage_CII; pfam05269 588858008369 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 588858008370 transcriptional repressor DicA; Reviewed; Region: PRK09706 588858008371 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 588858008372 non-specific DNA binding site [nucleotide binding]; other site 588858008373 salt bridge; other site 588858008374 sequence-specific DNA binding site [nucleotide binding]; other site 588858008375 AAA domain; Region: AAA_31; pfam13614 588858008376 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 588858008377 P-loop; other site 588858008378 Magnesium ion binding site [ion binding]; other site 588858008379 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 588858008380 Magnesium ion binding site [ion binding]; other site 588858008381 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 588858008382 exonuclease VIII; Reviewed; Region: PRK09709 588858008383 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 588858008384 RecT family; Region: RecT; pfam03837 588858008385 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 588858008386 integrase; Provisional; Region: PRK09692 588858008387 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 588858008388 active site 588858008389 Int/Topo IB signature motif; other site 588858008390 SoxR reducing system protein RseC; Provisional; Region: PRK10862 588858008391 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 588858008392 anti-sigma E factor; Provisional; Region: rseB; PRK09455 588858008393 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 588858008394 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 588858008395 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 588858008396 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 588858008397 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 588858008398 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 588858008399 DNA binding residues [nucleotide binding] 588858008400 L-aspartate oxidase; Provisional; Region: PRK09077 588858008401 L-aspartate oxidase; Provisional; Region: PRK06175 588858008402 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 588858008403 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 588858008404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 588858008405 S-adenosylmethionine binding site [chemical binding]; other site 588858008406 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 588858008407 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 588858008408 ATP binding site [chemical binding]; other site 588858008409 Mg++ binding site [ion binding]; other site 588858008410 motif III; other site 588858008411 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 588858008412 nucleotide binding region [chemical binding]; other site 588858008413 ATP-binding site [chemical binding]; other site 588858008414 Transcriptional regulator [Transcription]; Region: LysR; COG0583 588858008415 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858008416 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 588858008417 dimerization interface [polypeptide binding]; other site 588858008418 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 588858008419 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 588858008420 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 588858008421 ligand binding site [chemical binding]; other site 588858008422 active site 588858008423 UGI interface [polypeptide binding]; other site 588858008424 catalytic site [active] 588858008425 putative methyltransferase; Provisional; Region: PRK10864 588858008426 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 588858008427 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 588858008428 thioredoxin 2; Provisional; Region: PRK10996 588858008429 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 588858008430 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 588858008431 catalytic residues [active] 588858008432 Uncharacterized conserved protein [Function unknown]; Region: COG3148 588858008433 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 588858008434 CoA binding domain; Region: CoA_binding_2; pfam13380 588858008435 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 588858008436 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 588858008437 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 588858008438 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 588858008439 Coenzyme A binding pocket [chemical binding]; other site 588858008440 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 588858008441 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 588858008442 domain interface [polypeptide binding]; other site 588858008443 putative active site [active] 588858008444 catalytic site [active] 588858008445 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 588858008446 domain interface [polypeptide binding]; other site 588858008447 putative active site [active] 588858008448 catalytic site [active] 588858008449 lipoprotein; Provisional; Region: PRK10759 588858008450 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 588858008451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858008452 putative substrate translocation pore; other site 588858008453 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 588858008454 potential protein location (hypothetical protein STM14_3255 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]) that overlaps RNA (5S ribosomal RNA) 588858008455 protein disaggregation chaperone; Provisional; Region: PRK10865 588858008456 Clp amino terminal domain; Region: Clp_N; pfam02861 588858008457 Clp amino terminal domain; Region: Clp_N; pfam02861 588858008458 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 588858008459 Walker A motif; other site 588858008460 ATP binding site [chemical binding]; other site 588858008461 Walker B motif; other site 588858008462 arginine finger; other site 588858008463 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 588858008464 Walker A motif; other site 588858008465 ATP binding site [chemical binding]; other site 588858008466 Walker B motif; other site 588858008467 arginine finger; other site 588858008468 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 588858008469 hypothetical protein; Provisional; Region: PRK10723 588858008470 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 588858008471 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 588858008472 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 588858008473 RNA binding surface [nucleotide binding]; other site 588858008474 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 588858008475 active site 588858008476 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 588858008477 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 588858008478 pseudogene; two in-frame stops relative to Escherichia coli b2596 588858008479 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 588858008480 30S subunit binding site; other site 588858008481 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 588858008482 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 588858008483 Prephenate dehydratase; Region: PDT; pfam00800 588858008484 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 588858008485 putative L-Phe binding site [chemical binding]; other site 588858008486 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 588858008487 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 588858008488 Chorismate mutase type II; Region: CM_2; cl00693 588858008489 prephenate dehydrogenase; Validated; Region: PRK08507 588858008490 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 588858008491 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 588858008492 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 588858008493 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 588858008494 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 588858008495 metal binding site [ion binding]; metal-binding site 588858008496 active site 588858008497 I-site; other site 588858008498 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 588858008499 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 588858008500 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 588858008501 RimM N-terminal domain; Region: RimM; pfam01782 588858008502 PRC-barrel domain; Region: PRC; pfam05239 588858008503 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 588858008504 signal recognition particle protein; Provisional; Region: PRK10867 588858008505 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 588858008506 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 588858008507 P loop; other site 588858008508 GTP binding site [chemical binding]; other site 588858008509 Signal peptide binding domain; Region: SRP_SPB; pfam02978 588858008510 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 588858008511 hypothetical protein; Provisional; Region: PRK11573 588858008512 Domain of unknown function DUF21; Region: DUF21; pfam01595 588858008513 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 588858008514 Transporter associated domain; Region: CorC_HlyC; smart01091 588858008515 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 588858008516 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 588858008517 dimer interface [polypeptide binding]; other site 588858008518 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 588858008519 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 588858008520 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 588858008521 recombination and repair protein; Provisional; Region: PRK10869 588858008522 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 588858008523 Walker A/P-loop; other site 588858008524 ATP binding site [chemical binding]; other site 588858008525 Q-loop/lid; other site 588858008526 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 588858008527 ABC transporter signature motif; other site 588858008528 Walker B; other site 588858008529 D-loop; other site 588858008530 H-loop/switch region; other site 588858008531 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 588858008532 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 588858008533 hypothetical protein; Validated; Region: PRK01777 588858008534 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 588858008535 putative coenzyme Q binding site [chemical binding]; other site 588858008536 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 588858008537 SmpB-tmRNA interface; other site 588858008538 pseudogene; frameshift; proline/threonine-rich protein 588858008539 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 588858008540 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 588858008541 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 588858008542 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 588858008543 Walker A/P-loop; other site 588858008544 ATP binding site [chemical binding]; other site 588858008545 Q-loop/lid; other site 588858008546 ABC transporter signature motif; other site 588858008547 Walker B; other site 588858008548 D-loop; other site 588858008549 H-loop/switch region; other site 588858008550 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 588858008551 HlyD family secretion protein; Region: HlyD_3; pfam13437 588858008552 DNA-directed RNA polymerase II subunit 7; Provisional; Region: PTZ00162 588858008553 SEC-C motif; Region: SEC-C; pfam02810 588858008554 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 588858008555 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 588858008556 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 588858008557 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 588858008558 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 588858008559 non-specific DNA binding site [nucleotide binding]; other site 588858008560 salt bridge; other site 588858008561 sequence-specific DNA binding site [nucleotide binding]; other site 588858008562 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 588858008563 Phosphotransferase system sorbitol-specific component IIC [Carbohydrate transport and metabolism]; Region: SrlA; COG3730 588858008564 Phosphotransferase system sorbitol-specific component IIA [Carbohydrate transport and metabolism]; Region: SrlB; COG3731 588858008565 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 588858008566 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 588858008567 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 588858008568 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 588858008569 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 588858008570 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 588858008571 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 588858008572 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 588858008573 active site 588858008574 dimer interface [polypeptide binding]; other site 588858008575 magnesium binding site [ion binding]; other site 588858008576 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 588858008577 tetramer interface [polypeptide binding]; other site 588858008578 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 588858008579 active site 588858008580 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140 588858008581 Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560 588858008582 similar to Escherichia coli PTS system; glucose-specific IIBC component (AAC74185.1); disrupted by stop codon 588858008583 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 588858008584 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 588858008585 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 588858008586 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 588858008587 Integrase; Region: Integrase_1; pfam12835 588858008588 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 588858008589 HTH-like domain; Region: HTH_21; pfam13276 588858008590 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 588858008591 DNA-binding interface [nucleotide binding]; DNA binding site 588858008592 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 588858008593 Family description; Region: UvrD_C_2; pfam13538 588858008594 Transposase; Region: HTH_Tnp_1; cl17663 588858008595 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 588858008596 putative transposase OrfB; Reviewed; Region: PHA02517 588858008597 HTH-like domain; Region: HTH_21; pfam13276 588858008598 Integrase core domain; Region: rve; pfam00665 588858008599 Integrase core domain; Region: rve_2; pfam13333 588858008600 Repressor of phase-1 flagellin; Region: Flag1_repress; pfam03614 588858008601 flagellin; Validated; Region: PRK08026 588858008602 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 588858008603 Flagellin D3 domain; Region: Flagellin_D3; pfam08884 588858008604 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 588858008605 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 588858008606 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 588858008607 catalytic residues [active] 588858008608 catalytic nucleophile [active] 588858008609 Presynaptic Site I dimer interface [polypeptide binding]; other site 588858008610 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 588858008611 Synaptic Flat tetramer interface [polypeptide binding]; other site 588858008612 Synaptic Site I dimer interface [polypeptide binding]; other site 588858008613 DNA binding site [nucleotide binding] 588858008614 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 588858008615 DNA-binding interface [nucleotide binding]; DNA binding site 588858008616 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 588858008617 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 588858008618 homodimer interface [polypeptide binding]; other site 588858008619 active site 588858008620 TDP-binding site; other site 588858008621 acceptor substrate-binding pocket; other site 588858008622 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 588858008623 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 588858008624 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 588858008625 Walker A/P-loop; other site 588858008626 ATP binding site [chemical binding]; other site 588858008627 Q-loop/lid; other site 588858008628 ABC transporter signature motif; other site 588858008629 Walker B; other site 588858008630 D-loop; other site 588858008631 H-loop/switch region; other site 588858008632 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 588858008633 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 588858008634 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 588858008635 Walker A/P-loop; other site 588858008636 ATP binding site [chemical binding]; other site 588858008637 Q-loop/lid; other site 588858008638 ABC transporter signature motif; other site 588858008639 Walker B; other site 588858008640 D-loop; other site 588858008641 H-loop/switch region; other site 588858008642 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 588858008643 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 588858008644 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 588858008645 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 588858008646 outer membrane receptor FepA; Provisional; Region: PRK13528 588858008647 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 588858008648 N-terminal plug; other site 588858008649 ligand-binding site [chemical binding]; other site 588858008650 pseudogene; frameshift 588858008651 secreted effector protein PipB2; Provisional; Region: PRK15196 588858008652 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 588858008653 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 588858008654 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 588858008655 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 588858008656 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 588858008657 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 588858008658 antimicrobial resistance protein Mig-14; Provisional; Region: PRK15312 588858008659 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 588858008660 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 588858008661 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 588858008662 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 588858008663 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 588858008664 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 588858008665 dimer interface [polypeptide binding]; other site 588858008666 phosphorylation site [posttranslational modification] 588858008667 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 588858008668 ATP binding site [chemical binding]; other site 588858008669 Mg2+ binding site [ion binding]; other site 588858008670 G-X-G motif; other site 588858008671 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 588858008672 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 588858008673 active site 588858008674 phosphorylation site [posttranslational modification] 588858008675 intermolecular recognition site; other site 588858008676 dimerization interface [polypeptide binding]; other site 588858008677 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 588858008678 DNA binding site [nucleotide binding] 588858008679 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 588858008680 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 588858008681 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 588858008682 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 588858008683 substrate binding pocket [chemical binding]; other site 588858008684 active site 588858008685 iron coordination sites [ion binding]; other site 588858008686 Predicted dehydrogenase [General function prediction only]; Region: COG0579 588858008687 hydroxyglutarate oxidase; Provisional; Region: PRK11728 588858008688 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 588858008689 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 588858008690 tetramerization interface [polypeptide binding]; other site 588858008691 NAD(P) binding site [chemical binding]; other site 588858008692 catalytic residues [active] 588858008693 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 588858008694 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 588858008695 inhibitor-cofactor binding pocket; inhibition site 588858008696 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858008697 catalytic residue [active] 588858008698 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 588858008699 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 588858008700 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 588858008701 DNA-binding site [nucleotide binding]; DNA binding site 588858008702 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 588858008703 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 588858008704 bacterial OsmY and nodulation domain; Region: BON; smart00749 588858008705 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 588858008706 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 588858008707 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 588858008708 dimerization interface [polypeptide binding]; other site 588858008709 putative DNA binding site [nucleotide binding]; other site 588858008710 Transcriptional regulators [Transcription]; Region: MarR; COG1846 588858008711 putative Zn2+ binding site [ion binding]; other site 588858008712 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 588858008713 active site residue [active] 588858008714 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 588858008715 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 588858008716 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 588858008717 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 588858008718 hypothetical protein; Provisional; Region: PRK10556 588858008719 hypothetical protein; Provisional; Region: PRK10132 588858008720 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 588858008721 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 588858008722 DNA-binding site [nucleotide binding]; DNA binding site 588858008723 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 588858008724 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858008725 homodimer interface [polypeptide binding]; other site 588858008726 catalytic residue [active] 588858008727 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 588858008728 Uncharacterized conserved protein [Function unknown]; Region: COG2128 588858008729 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 588858008730 catalytic residues [active] 588858008731 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 588858008732 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 588858008733 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 588858008734 Class I ribonucleotide reductase; Region: RNR_I; cd01679 588858008735 active site 588858008736 dimer interface [polypeptide binding]; other site 588858008737 catalytic residues [active] 588858008738 effector binding site; other site 588858008739 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 588858008740 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 588858008741 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 588858008742 dimer interface [polypeptide binding]; other site 588858008743 putative radical transfer pathway; other site 588858008744 diiron center [ion binding]; other site 588858008745 tyrosyl radical; other site 588858008746 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 588858008747 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 588858008748 Walker A/P-loop; other site 588858008749 ATP binding site [chemical binding]; other site 588858008750 Q-loop/lid; other site 588858008751 ABC transporter signature motif; other site 588858008752 Walker B; other site 588858008753 D-loop; other site 588858008754 H-loop/switch region; other site 588858008755 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 588858008756 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 588858008757 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858008758 dimer interface [polypeptide binding]; other site 588858008759 conserved gate region; other site 588858008760 putative PBP binding loops; other site 588858008761 ABC-ATPase subunit interface; other site 588858008762 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 588858008763 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 588858008764 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 588858008765 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858008766 transcriptional repressor MprA; Provisional; Region: PRK10870 588858008767 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 588858008768 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 588858008769 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 588858008770 HlyD family secretion protein; Region: HlyD_3; pfam13437 588858008771 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 588858008772 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858008773 putative substrate translocation pore; other site 588858008774 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858008775 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 588858008776 S-ribosylhomocysteinase; Provisional; Region: PRK02260 588858008777 glutamate--cysteine ligase; Provisional; Region: PRK02107 588858008778 Predicted membrane protein [Function unknown]; Region: COG1238 588858008779 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 588858008780 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 588858008781 motif II; other site 588858008782 carbon storage regulator; Provisional; Region: PRK01712 588858008783 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 588858008784 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 588858008785 motif 1; other site 588858008786 active site 588858008787 motif 2; other site 588858008788 motif 3; other site 588858008789 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 588858008790 DHHA1 domain; Region: DHHA1; pfam02272 588858008791 recombination regulator RecX; Reviewed; Region: recX; PRK00117 588858008792 recombinase A; Provisional; Region: recA; PRK09354 588858008793 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 588858008794 hexamer interface [polypeptide binding]; other site 588858008795 Walker A motif; other site 588858008796 ATP binding site [chemical binding]; other site 588858008797 Walker B motif; other site 588858008798 hypothetical protein; Validated; Region: PRK03661 588858008799 Transglycosylase SLT domain; Region: SLT_2; pfam13406 588858008800 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 588858008801 N-acetyl-D-glucosamine binding site [chemical binding]; other site 588858008802 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 588858008803 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 588858008804 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 588858008805 Nucleoside recognition; Region: Gate; pfam07670 588858008806 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 588858008807 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 588858008808 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 588858008809 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 588858008810 putative NAD(P) binding site [chemical binding]; other site 588858008811 active site 588858008812 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 588858008813 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 588858008814 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 588858008815 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 588858008816 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 588858008817 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 588858008818 putative active site [active] 588858008819 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 588858008820 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 588858008821 GAF domain; Region: GAF; pfam01590 588858008822 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 588858008823 Walker A motif; other site 588858008824 ATP binding site [chemical binding]; other site 588858008825 Walker B motif; other site 588858008826 arginine finger; other site 588858008827 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 588858008828 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 588858008829 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 588858008830 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 588858008831 iron binding site [ion binding]; other site 588858008832 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 588858008833 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 588858008834 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 588858008835 Acylphosphatase; Region: Acylphosphatase; pfam00708 588858008836 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 588858008837 HypF finger; Region: zf-HYPF; pfam07503 588858008838 HypF finger; Region: zf-HYPF; pfam07503 588858008839 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 588858008840 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 588858008841 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 588858008842 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 588858008843 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 588858008844 nickel binding site [ion binding]; other site 588858008845 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 588858008846 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 588858008847 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 588858008848 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 588858008849 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 588858008850 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 588858008851 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 588858008852 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 588858008853 NADH dehydrogenase; Region: NADHdh; cl00469 588858008854 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 588858008855 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 588858008856 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 588858008857 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 588858008858 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 588858008859 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 588858008860 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 588858008861 hydrogenase assembly chaperone; Provisional; Region: PRK10409 588858008862 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 588858008863 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 588858008864 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 588858008865 dimerization interface [polypeptide binding]; other site 588858008866 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 588858008867 ATP binding site [chemical binding]; other site 588858008868 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 588858008869 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 588858008870 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 588858008871 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 588858008872 Walker A motif; other site 588858008873 ATP binding site [chemical binding]; other site 588858008874 Walker B motif; other site 588858008875 arginine finger; other site 588858008876 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 588858008877 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 588858008878 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 588858008879 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 588858008880 metal binding site [ion binding]; metal-binding site 588858008881 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 588858008882 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 588858008883 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 588858008884 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 588858008885 ABC-ATPase subunit interface; other site 588858008886 dimer interface [polypeptide binding]; other site 588858008887 putative PBP binding regions; other site 588858008888 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 588858008889 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 588858008890 ABC-ATPase subunit interface; other site 588858008891 dimer interface [polypeptide binding]; other site 588858008892 putative PBP binding regions; other site 588858008893 transcriptional activator SprB; Provisional; Region: PRK15320 588858008894 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 588858008895 transcriptional regulator SirC; Provisional; Region: PRK15044 588858008896 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 588858008897 putative type III secretion system effector protein OrgC; Provisional; Region: PRK15321 588858008898 invasion protein OrgB; Provisional; Region: PRK15322 588858008899 type III secretion apparatus protein OrgA/MxiK; Region: OrgA_MxiK; TIGR02555 588858008900 invasion protein OrgA; Provisional; Region: PRK15323 588858008901 type III secretion system lipoprotein PrgK; Provisional; Region: PRK15324 588858008902 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 588858008903 type III secretion system needle complex protein PrgI; Provisional; Region: PRK15326 588858008904 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327 588858008905 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 588858008906 transcriptional regulator HilD; Provisional; Region: PRK15185 588858008907 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 588858008908 invasion protein regulator; Provisional; Region: PRK12370 588858008909 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 588858008910 DNA binding site [nucleotide binding] 588858008911 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 588858008912 binding surface 588858008913 TPR motif; other site 588858008914 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 588858008915 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 588858008916 N-acetyl-D-glucosamine binding site [chemical binding]; other site 588858008917 catalytic residue [active] 588858008918 pathogenicity island 1 effector protein StpP; Provisional; Region: PRK15375 588858008919 SicP binding; Region: SicP-binding; pfam09119 588858008920 GTPase-activating protein (GAP) domain found in bacterial cytotoxins, ExoS, SptP, and YopE. Part of protein secretion system; stimulates Rac1- dependent cytoskeletal changes that promote bacterial internalization; Region: ToxGAP; cd00219 588858008921 switch II binding region; other site 588858008922 Rac1 P-loop interaction site [polypeptide binding]; other site 588858008923 GTP binding residues [chemical binding]; other site 588858008924 switch I binding region; other site 588858008925 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047 588858008926 active site 588858008927 chaperone protein SicP; Provisional; Region: PRK15329 588858008928 putative acyl carrier protein IacP; Validated; Region: PRK08172 588858008929 pathogenicity island 1 effector protein SipA; Provisional; Region: PRK15376 588858008930 cell invasion protein SipD; Provisional; Region: PRK15330 588858008931 pathogenicity island 1 effector protein SipC; Provisional; Region: PRK15373 588858008932 pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374 588858008933 chaperone protein SicA; Provisional; Region: PRK15331 588858008934 Tetratricopeptide repeat; Region: TPR_3; pfam07720 588858008935 Tetratricopeptide repeat; Region: TPR_3; pfam07720 588858008936 type III secretion system protein SpaS; Validated; Region: PRK08156 588858008937 type III secretion system protein SpaR; Provisional; Region: PRK15332 588858008938 type III secretion system protein SpaQ; Provisional; Region: PRK15333 588858008939 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 588858008940 type III secretion system protein SpaO; Validated; Region: PRK08158 588858008941 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 588858008942 antigen presentation protein SpaN; Provisional; Region: PRK15334 588858008943 Surface presentation of antigens protein; Region: SPAN; pfam02510 588858008944 Salmonella surface presentation of antigen gene type M protein; Region: SPAM; pfam02090 588858008945 ATP synthase SpaL; Validated; Region: PRK08149 588858008946 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 588858008947 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 588858008948 Walker A motif; other site 588858008949 ATP binding site [chemical binding]; other site 588858008950 Walker B motif; other site 588858008951 type III secretion system chaperone SpaK; Provisional; Region: PRK15336 588858008952 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 588858008953 type III secretion system protein InvA; Provisional; Region: PRK15337 588858008954 type III secretion system regulator InvE; Provisional; Region: PRK15338 588858008955 type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568 588858008956 type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339 588858008957 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 588858008958 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 588858008959 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 588858008960 transcriptional regulator InvF; Provisional; Region: PRK15340 588858008961 InvH outer membrane lipoprotein; Region: InvH; pfam04741 588858008962 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 588858008963 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 588858008964 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 588858008965 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 588858008966 active site 588858008967 metal binding site [ion binding]; metal-binding site 588858008968 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 588858008969 MutS domain I; Region: MutS_I; pfam01624 588858008970 MutS domain II; Region: MutS_II; pfam05188 588858008971 MutS domain III; Region: MutS_III; pfam05192 588858008972 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 588858008973 Walker A/P-loop; other site 588858008974 ATP binding site [chemical binding]; other site 588858008975 Q-loop/lid; other site 588858008976 ABC transporter signature motif; other site 588858008977 Walker B; other site 588858008978 D-loop; other site 588858008979 H-loop/switch region; other site 588858008980 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 588858008981 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858008982 Major Facilitator Superfamily; Region: MFS_1; pfam07690 588858008983 putative substrate translocation pore; other site 588858008984 Transcriptional regulator [Transcription]; Region: LysR; COG0583 588858008985 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858008986 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 588858008987 putative effector binding pocket; other site 588858008988 dimerization interface [polypeptide binding]; other site 588858008989 GntP family permease; Region: GntP_permease; pfam02447 588858008990 fructuronate transporter; Provisional; Region: PRK10034; cl15264 588858008991 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 588858008992 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 588858008993 putative NAD(P) binding site [chemical binding]; other site 588858008994 active site 588858008995 putative substrate binding site [chemical binding]; other site 588858008996 hypothetical protein; Provisional; Region: PRK09989 588858008997 putative aldolase; Validated; Region: PRK08130 588858008998 intersubunit interface [polypeptide binding]; other site 588858008999 active site 588858009000 Zn2+ binding site [ion binding]; other site 588858009001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 588858009002 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 588858009003 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 588858009004 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 588858009005 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 588858009006 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 588858009007 MarR family; Region: MarR_2; cl17246 588858009008 Transcriptional regulators [Transcription]; Region: MarR; COG1846 588858009009 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 588858009010 Flavoprotein; Region: Flavoprotein; pfam02441 588858009011 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 588858009012 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 588858009013 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 588858009014 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 588858009015 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 588858009016 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 588858009017 DNA binding residues [nucleotide binding] 588858009018 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 588858009019 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 588858009020 Peptidase family M23; Region: Peptidase_M23; pfam01551 588858009021 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 588858009022 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 588858009023 S-adenosylmethionine binding site [chemical binding]; other site 588858009024 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 588858009025 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 588858009026 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 588858009027 Permutation of conserved domain; other site 588858009028 active site 588858009029 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 588858009030 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 588858009031 homotrimer interaction site [polypeptide binding]; other site 588858009032 zinc binding site [ion binding]; other site 588858009033 CDP-binding sites; other site 588858009034 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 588858009035 substrate binding site; other site 588858009036 dimer interface; other site 588858009037 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 588858009038 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 588858009039 Cwf15/Cwc15 cell cycle control protein; Region: Cwf_Cwc_15; pfam04889 588858009040 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 588858009041 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 588858009042 ligand-binding site [chemical binding]; other site 588858009043 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 588858009044 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 588858009045 CysD dimerization site [polypeptide binding]; other site 588858009046 G1 box; other site 588858009047 putative GEF interaction site [polypeptide binding]; other site 588858009048 GTP/Mg2+ binding site [chemical binding]; other site 588858009049 Switch I region; other site 588858009050 G2 box; other site 588858009051 G3 box; other site 588858009052 Switch II region; other site 588858009053 G4 box; other site 588858009054 G5 box; other site 588858009055 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 588858009056 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 588858009057 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 588858009058 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 588858009059 Active Sites [active] 588858009060 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 588858009061 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 588858009062 metal binding site [ion binding]; metal-binding site 588858009063 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 588858009064 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 588858009065 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 588858009066 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 588858009067 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 588858009068 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646 588858009069 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 588858009070 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 588858009071 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 588858009072 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 588858009073 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 588858009074 pathogenicity island 1 effector protein SopD; Provisional; Region: PRK15379 588858009075 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 588858009076 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 588858009077 Active Sites [active] 588858009078 sulfite reductase subunit beta; Provisional; Region: PRK13504 588858009079 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 588858009080 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 588858009081 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 588858009082 Flavodoxin; Region: Flavodoxin_1; pfam00258 588858009083 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 588858009084 FAD binding pocket [chemical binding]; other site 588858009085 FAD binding motif [chemical binding]; other site 588858009086 catalytic residues [active] 588858009087 NAD binding pocket [chemical binding]; other site 588858009088 phosphate binding motif [ion binding]; other site 588858009089 beta-alpha-beta structure motif; other site 588858009090 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 588858009091 active site 588858009092 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 588858009093 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 588858009094 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 588858009095 enolase; Provisional; Region: eno; PRK00077 588858009096 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 588858009097 dimer interface [polypeptide binding]; other site 588858009098 metal binding site [ion binding]; metal-binding site 588858009099 substrate binding pocket [chemical binding]; other site 588858009100 CTP synthetase; Validated; Region: pyrG; PRK05380 588858009101 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 588858009102 Catalytic site [active] 588858009103 active site 588858009104 UTP binding site [chemical binding]; other site 588858009105 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 588858009106 active site 588858009107 putative oxyanion hole; other site 588858009108 catalytic triad [active] 588858009109 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 588858009110 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 588858009111 homodimer interface [polypeptide binding]; other site 588858009112 metal binding site [ion binding]; metal-binding site 588858009113 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 588858009114 homodimer interface [polypeptide binding]; other site 588858009115 active site 588858009116 putative chemical substrate binding site [chemical binding]; other site 588858009117 metal binding site [ion binding]; metal-binding site 588858009118 Fimbrial protein; Region: Fimbrial; cl01416 588858009119 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 588858009120 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 588858009121 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 588858009122 HD domain; Region: HD_4; pfam13328 588858009123 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 588858009124 synthetase active site [active] 588858009125 NTP binding site [chemical binding]; other site 588858009126 metal binding site [ion binding]; metal-binding site 588858009127 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 588858009128 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 588858009129 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 588858009130 TRAM domain; Region: TRAM; pfam01938 588858009131 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 588858009132 S-adenosylmethionine binding site [chemical binding]; other site 588858009133 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 588858009134 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 588858009135 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 588858009136 dimerization interface [polypeptide binding]; other site 588858009137 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 588858009138 dimer interface [polypeptide binding]; other site 588858009139 phosphorylation site [posttranslational modification] 588858009140 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 588858009141 ATP binding site [chemical binding]; other site 588858009142 Mg2+ binding site [ion binding]; other site 588858009143 G-X-G motif; other site 588858009144 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 588858009145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 588858009146 active site 588858009147 phosphorylation site [posttranslational modification] 588858009148 intermolecular recognition site; other site 588858009149 dimerization interface [polypeptide binding]; other site 588858009150 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 588858009151 putative binding surface; other site 588858009152 active site 588858009153 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 588858009154 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 588858009155 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 588858009156 active site 588858009157 tetramer interface [polypeptide binding]; other site 588858009158 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 588858009159 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 588858009160 active site 588858009161 tetramer interface [polypeptide binding]; other site 588858009162 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858009163 D-galactonate transporter; Region: 2A0114; TIGR00893 588858009164 putative substrate translocation pore; other site 588858009165 flavodoxin; Provisional; Region: PRK08105 588858009166 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 588858009167 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 588858009168 probable active site [active] 588858009169 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 588858009170 SecY interacting protein Syd; Provisional; Region: PRK04968 588858009171 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 588858009172 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 588858009173 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 588858009174 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 588858009175 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 588858009176 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 588858009177 serine transporter; Region: stp; TIGR00814 588858009178 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 588858009179 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 588858009180 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 588858009181 flap endonuclease-like protein; Provisional; Region: PRK09482 588858009182 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 588858009183 active site 588858009184 metal binding site 1 [ion binding]; metal-binding site 588858009185 putative 5' ssDNA interaction site; other site 588858009186 metal binding site 3; metal-binding site 588858009187 metal binding site 2 [ion binding]; metal-binding site 588858009188 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 588858009189 putative DNA binding site [nucleotide binding]; other site 588858009190 putative metal binding site [ion binding]; other site 588858009191 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 588858009192 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 588858009193 dimer interface [polypeptide binding]; other site 588858009194 active site 588858009195 metal binding site [ion binding]; metal-binding site 588858009196 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 588858009197 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 588858009198 intersubunit interface [polypeptide binding]; other site 588858009199 active site 588858009200 Zn2+ binding site [ion binding]; other site 588858009201 pseudogene; frameshift; fucose permease 588858009202 L-fucose isomerase; Provisional; Region: fucI; PRK10991 588858009203 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 588858009204 hexamer (dimer of trimers) interface [polypeptide binding]; other site 588858009205 trimer interface [polypeptide binding]; other site 588858009206 substrate binding site [chemical binding]; other site 588858009207 Mn binding site [ion binding]; other site 588858009208 L-fuculokinase; Provisional; Region: PRK10331 588858009209 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 588858009210 nucleotide binding site [chemical binding]; other site 588858009211 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 588858009212 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 588858009213 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 588858009214 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 588858009215 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 588858009216 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 588858009217 hypothetical protein; Provisional; Region: PRK10873 588858009218 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 588858009219 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858009220 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 588858009221 dimerization interface [polypeptide binding]; other site 588858009222 substrate binding pocket [chemical binding]; other site 588858009223 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 588858009224 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 588858009225 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 588858009226 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 588858009227 catalytic residue [active] 588858009228 CsdA-binding activator; Provisional; Region: PRK15019 588858009229 Predicted permeases [General function prediction only]; Region: RarD; COG2962 588858009230 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 588858009231 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 588858009232 putative ATP binding site [chemical binding]; other site 588858009233 putative substrate interface [chemical binding]; other site 588858009234 murein transglycosylase A; Provisional; Region: mltA; PRK11162 588858009235 murein hydrolase B; Provisional; Region: PRK10760; cl17906 588858009236 MltA specific insert domain; Region: MltA; pfam03562 588858009237 3D domain; Region: 3D; pfam06725 588858009238 AMIN domain; Region: AMIN; pfam11741 588858009239 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 588858009240 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 588858009241 active site 588858009242 metal binding site [ion binding]; metal-binding site 588858009243 N-acetylglutamate synthase; Validated; Region: PRK05279 588858009244 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 588858009245 putative feedback inhibition sensing region; other site 588858009246 putative nucleotide binding site [chemical binding]; other site 588858009247 putative substrate binding site [chemical binding]; other site 588858009248 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 588858009249 Coenzyme A binding pocket [chemical binding]; other site 588858009250 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 588858009251 AAA domain; Region: AAA_30; pfam13604 588858009252 Family description; Region: UvrD_C_2; pfam13538 588858009253 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 588858009254 protease3; Provisional; Region: PRK15101 588858009255 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 588858009256 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 588858009257 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 588858009258 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 588858009259 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 588858009260 hypothetical protein; Provisional; Region: PRK10332 588858009261 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 588858009262 hypothetical protein; Provisional; Region: PRK11521 588858009263 hypothetical protein; Provisional; Region: PRK10557 588858009264 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 588858009265 hypothetical protein; Provisional; Region: PRK10506 588858009266 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 588858009267 thymidylate synthase; Reviewed; Region: thyA; PRK01827 588858009268 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 588858009269 dimerization interface [polypeptide binding]; other site 588858009270 active site 588858009271 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 588858009272 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 588858009273 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 588858009274 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 588858009275 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 588858009276 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 588858009277 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 588858009278 putative active site [active] 588858009279 Ap4A binding site [chemical binding]; other site 588858009280 nudix motif; other site 588858009281 putative metal binding site [ion binding]; other site 588858009282 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 588858009283 putative DNA-binding cleft [nucleotide binding]; other site 588858009284 putative DNA clevage site; other site 588858009285 molecular lever; other site 588858009286 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 588858009287 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 588858009288 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 588858009289 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 588858009290 active site 588858009291 catalytic tetrad [active] 588858009292 lysophospholipid transporter LplT; Provisional; Region: PRK11195 588858009293 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858009294 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 588858009295 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 588858009296 putative acyl-acceptor binding pocket; other site 588858009297 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 588858009298 acyl-activating enzyme (AAE) consensus motif; other site 588858009299 putative AMP binding site [chemical binding]; other site 588858009300 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 588858009301 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 588858009302 DNA binding site [nucleotide binding] 588858009303 domain linker motif; other site 588858009304 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 588858009305 dimerization interface (closed form) [polypeptide binding]; other site 588858009306 ligand binding site [chemical binding]; other site 588858009307 Transcriptional regulators [Transcription]; Region: PurR; COG1609 588858009308 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 588858009309 DNA binding site [nucleotide binding] 588858009310 domain linker motif; other site 588858009311 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 588858009312 dimerization interface (closed form) [polypeptide binding]; other site 588858009313 ligand binding site [chemical binding]; other site 588858009314 diaminopimelate decarboxylase; Provisional; Region: PRK11165 588858009315 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 588858009316 active site 588858009317 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 588858009318 substrate binding site [chemical binding]; other site 588858009319 catalytic residues [active] 588858009320 dimer interface [polypeptide binding]; other site 588858009321 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 588858009322 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858009323 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 588858009324 dimerization interface [polypeptide binding]; other site 588858009325 putative racemase; Provisional; Region: PRK10200 588858009326 aspartate racemase; Region: asp_race; TIGR00035 588858009327 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 588858009328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858009329 putative substrate translocation pore; other site 588858009330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858009331 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 588858009332 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 588858009333 NADP binding site [chemical binding]; other site 588858009334 homodimer interface [polypeptide binding]; other site 588858009335 active site 588858009336 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 588858009337 putative acyltransferase; Provisional; Region: PRK05790 588858009338 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 588858009339 dimer interface [polypeptide binding]; other site 588858009340 active site 588858009341 Transcriptional regulator [Transcription]; Region: LysR; COG0583 588858009342 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858009343 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 588858009344 dimerization interface [polypeptide binding]; other site 588858009345 Predicted membrane protein [Function unknown]; Region: COG4125 588858009346 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 588858009347 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 588858009348 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 588858009349 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 588858009350 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 588858009351 putative metal binding site [ion binding]; other site 588858009352 putative homodimer interface [polypeptide binding]; other site 588858009353 putative homotetramer interface [polypeptide binding]; other site 588858009354 putative homodimer-homodimer interface [polypeptide binding]; other site 588858009355 putative allosteric switch controlling residues; other site 588858009356 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 588858009357 transcriptional activator SprB; Provisional; Region: PRK15320 588858009358 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14600 588858009359 Protein of unknown function (DUF1401); Region: DUF1401; pfam07180 588858009360 Fimbrial protein; Region: Fimbrial; pfam00419 588858009361 fimbrial chaperone protein StdC; Provisional; Region: PRK15254 588858009362 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 588858009363 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 588858009364 fimbrial outer membrane usher protein StdB; Provisional; Region: PRK15255 588858009365 PapC N-terminal domain; Region: PapC_N; pfam13954 588858009366 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 588858009367 PapC C-terminal domain; Region: PapC_C; pfam13953 588858009368 fimbrial protein StdA; Provisional; Region: PRK15210 588858009369 hypothetical protein; Provisional; Region: PRK10316 588858009370 YfdX protein; Region: YfdX; pfam10938 588858009371 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 588858009372 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 588858009373 oligomeric interface; other site 588858009374 putative active site [active] 588858009375 homodimer interface [polypeptide binding]; other site 588858009376 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 588858009377 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 588858009378 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 588858009379 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 588858009380 Peptidase family M23; Region: Peptidase_M23; pfam01551 588858009381 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 588858009382 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 588858009383 active site 588858009384 metal binding site [ion binding]; metal-binding site 588858009385 nudix motif; other site 588858009386 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 588858009387 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 588858009388 dimer interface [polypeptide binding]; other site 588858009389 putative anticodon binding site; other site 588858009390 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 588858009391 motif 1; other site 588858009392 active site 588858009393 motif 2; other site 588858009394 motif 3; other site 588858009395 peptide chain release factor 2; Validated; Region: prfB; PRK00578 588858009396 This domain is found in peptide chain release factors; Region: PCRF; smart00937 588858009397 RF-1 domain; Region: RF-1; pfam00472 588858009398 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 588858009399 DHH family; Region: DHH; pfam01368 588858009400 DHHA1 domain; Region: DHHA1; pfam02272 588858009401 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 588858009402 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 588858009403 dimerization domain [polypeptide binding]; other site 588858009404 dimer interface [polypeptide binding]; other site 588858009405 catalytic residues [active] 588858009406 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 588858009407 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 588858009408 active site 588858009409 Int/Topo IB signature motif; other site 588858009410 flavodoxin FldB; Provisional; Region: PRK12359 588858009411 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 588858009412 hypothetical protein; Provisional; Region: PRK10878 588858009413 putative global regulator; Reviewed; Region: PRK09559 588858009414 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 588858009415 hemolysin; Provisional; Region: PRK15087 588858009416 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 588858009417 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 588858009418 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 588858009419 beta-galactosidase; Region: BGL; TIGR03356 588858009420 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 588858009421 glycine dehydrogenase; Provisional; Region: PRK05367 588858009422 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 588858009423 tetramer interface [polypeptide binding]; other site 588858009424 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858009425 catalytic residue [active] 588858009426 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 588858009427 tetramer interface [polypeptide binding]; other site 588858009428 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858009429 catalytic residue [active] 588858009430 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 588858009431 lipoyl attachment site [posttranslational modification]; other site 588858009432 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 588858009433 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 588858009434 oxidoreductase; Provisional; Region: PRK08013 588858009435 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 588858009436 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 588858009437 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 588858009438 proline aminopeptidase P II; Provisional; Region: PRK10879 588858009439 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 588858009440 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 588858009441 active site 588858009442 hypothetical protein; Reviewed; Region: PRK01736 588858009443 Z-ring-associated protein; Provisional; Region: PRK10972 588858009444 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 588858009445 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 588858009446 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 588858009447 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 588858009448 ligand binding site [chemical binding]; other site 588858009449 NAD binding site [chemical binding]; other site 588858009450 tetramer interface [polypeptide binding]; other site 588858009451 catalytic site [active] 588858009452 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 588858009453 L-serine binding site [chemical binding]; other site 588858009454 ACT domain interface; other site 588858009455 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 588858009456 tetramer (dimer of dimers) interface [polypeptide binding]; other site 588858009457 active site 588858009458 dimer interface [polypeptide binding]; other site 588858009459 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 588858009460 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858009461 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 588858009462 putative dimerization interface [polypeptide binding]; other site 588858009463 Uncharacterized conserved protein [Function unknown]; Region: COG2968 588858009464 oxidative stress defense protein; Provisional; Region: PRK11087 588858009465 arginine exporter protein; Provisional; Region: PRK09304 588858009466 mechanosensitive channel MscS; Provisional; Region: PRK10334 588858009467 Mechanosensitive ion channel; Region: MS_channel; pfam00924 588858009468 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 588858009469 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 588858009470 active site 588858009471 intersubunit interface [polypeptide binding]; other site 588858009472 zinc binding site [ion binding]; other site 588858009473 Na+ binding site [ion binding]; other site 588858009474 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 588858009475 Phosphoglycerate kinase; Region: PGK; pfam00162 588858009476 substrate binding site [chemical binding]; other site 588858009477 hinge regions; other site 588858009478 ADP binding site [chemical binding]; other site 588858009479 catalytic site [active] 588858009480 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 588858009481 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 588858009482 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 588858009483 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 588858009484 trimer interface [polypeptide binding]; other site 588858009485 putative Zn binding site [ion binding]; other site 588858009486 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 588858009487 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 588858009488 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 588858009489 Walker A/P-loop; other site 588858009490 ATP binding site [chemical binding]; other site 588858009491 Q-loop/lid; other site 588858009492 ABC transporter signature motif; other site 588858009493 Walker B; other site 588858009494 D-loop; other site 588858009495 H-loop/switch region; other site 588858009496 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 588858009497 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 588858009498 Walker A/P-loop; other site 588858009499 ATP binding site [chemical binding]; other site 588858009500 Q-loop/lid; other site 588858009501 ABC transporter signature motif; other site 588858009502 Walker B; other site 588858009503 D-loop; other site 588858009504 H-loop/switch region; other site 588858009505 transketolase; Reviewed; Region: PRK12753 588858009506 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 588858009507 TPP-binding site [chemical binding]; other site 588858009508 dimer interface [polypeptide binding]; other site 588858009509 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 588858009510 PYR/PP interface [polypeptide binding]; other site 588858009511 dimer interface [polypeptide binding]; other site 588858009512 TPP binding site [chemical binding]; other site 588858009513 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 588858009514 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 588858009515 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 588858009516 agmatinase; Region: agmatinase; TIGR01230 588858009517 oligomer interface [polypeptide binding]; other site 588858009518 putative active site [active] 588858009519 Mn binding site [ion binding]; other site 588858009520 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 588858009521 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 588858009522 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 588858009523 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 588858009524 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 588858009525 putative NAD(P) binding site [chemical binding]; other site 588858009526 catalytic Zn binding site [ion binding]; other site 588858009527 structural Zn binding site [ion binding]; other site 588858009528 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 588858009529 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 588858009530 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 588858009531 Transcriptional regulators [Transcription]; Region: FadR; COG2186 588858009532 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 588858009533 DNA-binding site [nucleotide binding]; DNA binding site 588858009534 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 588858009535 DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237 588858009536 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 588858009537 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 588858009538 dimer interface [polypeptide binding]; other site 588858009539 active site 588858009540 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 588858009541 catalytic residues [active] 588858009542 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 588858009543 Virulence promoting factor; Region: YqgB; pfam11036 588858009544 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 588858009545 S-adenosylmethionine synthetase; Validated; Region: PRK05250 588858009546 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 588858009547 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 588858009548 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 588858009549 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 588858009550 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858009551 putative substrate translocation pore; other site 588858009552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858009553 hypothetical protein; Provisional; Region: PRK04860 588858009554 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 588858009555 DNA-specific endonuclease I; Provisional; Region: PRK15137 588858009556 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 588858009557 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 588858009558 RNA methyltransferase, RsmE family; Region: TIGR00046 588858009559 glutathione synthetase; Provisional; Region: PRK05246 588858009560 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 588858009561 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 588858009562 hypothetical protein; Validated; Region: PRK00228 588858009563 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 588858009564 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 588858009565 Transcriptional regulator [Transcription]; Region: IclR; COG1414 588858009566 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 588858009567 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 588858009568 Walker A motif; other site 588858009569 ATP binding site [chemical binding]; other site 588858009570 Walker B motif; other site 588858009571 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 588858009572 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 588858009573 catalytic residue [active] 588858009574 YGGT family; Region: YGGT; pfam02325 588858009575 YGGT family; Region: YGGT; pfam02325 588858009576 hypothetical protein; Validated; Region: PRK05090 588858009577 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 588858009578 active site 588858009579 dimerization interface [polypeptide binding]; other site 588858009580 HemN family oxidoreductase; Provisional; Region: PRK05660 588858009581 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 588858009582 FeS/SAM binding site; other site 588858009583 HemN C-terminal domain; Region: HemN_C; pfam06969 588858009584 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 588858009585 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 588858009586 homodimer interface [polypeptide binding]; other site 588858009587 active site 588858009588 hypothetical protein; Provisional; Region: PRK10626 588858009589 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 588858009590 hypothetical protein; Provisional; Region: PRK11702 588858009591 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 588858009592 adenine DNA glycosylase; Provisional; Region: PRK10880 588858009593 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 588858009594 minor groove reading motif; other site 588858009595 helix-hairpin-helix signature motif; other site 588858009596 substrate binding pocket [chemical binding]; other site 588858009597 active site 588858009598 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 588858009599 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 588858009600 DNA binding and oxoG recognition site [nucleotide binding] 588858009601 oxidative damage protection protein; Provisional; Region: PRK05408 588858009602 murein transglycosylase C; Provisional; Region: mltC; PRK11671 588858009603 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 588858009604 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 588858009605 N-acetyl-D-glucosamine binding site [chemical binding]; other site 588858009606 catalytic residue [active] 588858009607 similar to Escherichia coli transport of nucleosides, permease protein (AAC76001.1); MFS family 588858009608 ornithine decarboxylase; Provisional; Region: PRK13578 588858009609 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 588858009610 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 588858009611 homodimer interface [polypeptide binding]; other site 588858009612 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858009613 catalytic residue [active] 588858009614 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 588858009615 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 588858009616 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 588858009617 dimer interface [polypeptide binding]; other site 588858009618 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 588858009619 metal binding site [ion binding]; metal-binding site 588858009620 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 588858009621 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 588858009622 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 588858009623 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 588858009624 putative active site [active] 588858009625 putative catalytic site [active] 588858009626 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 588858009627 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 588858009628 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858009629 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 588858009630 putative dimerization interface [polypeptide binding]; other site 588858009631 putative substrate binding pocket [chemical binding]; other site 588858009632 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 588858009633 Sulfatase; Region: Sulfatase; pfam00884 588858009634 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 588858009635 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 588858009636 FeS/SAM binding site; other site 588858009637 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 588858009638 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 588858009639 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 588858009640 DNA binding residues [nucleotide binding] 588858009641 dimerization interface [polypeptide binding]; other site 588858009642 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 588858009643 Amino acid permease; Region: AA_permease_2; pfam13520 588858009644 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 588858009645 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 588858009646 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 588858009647 Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113 588858009648 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 588858009649 NAD(P) binding site [chemical binding]; other site 588858009650 catalytic residues [active] 588858009651 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 588858009652 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 588858009653 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 588858009654 active site 588858009655 catalytic site [active] 588858009656 Zn binding site [ion binding]; other site 588858009657 tetramer interface [polypeptide binding]; other site 588858009658 putative amidohydrolase; disrupted by frameshift 588858009659 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858009660 D-galactonate transporter; Region: 2A0114; TIGR00893 588858009661 putative substrate translocation pore; other site 588858009662 mannonate dehydratase; Provisional; Region: PRK03906 588858009663 mannonate dehydratase; Region: uxuA; TIGR00695 588858009664 D-mannonate oxidoreductase; Provisional; Region: PRK15037 588858009665 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 588858009666 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 588858009667 Glucuronate isomerase; Region: UxaC; pfam02614 588858009668 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 588858009669 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 588858009670 dimer interface [polypeptide binding]; other site 588858009671 putative CheW interface [polypeptide binding]; other site 588858009672 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 588858009673 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 588858009674 CHAP domain; Region: CHAP; pfam05257 588858009675 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 588858009676 putative S-transferase; Provisional; Region: PRK11752 588858009677 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 588858009678 C-terminal domain interface [polypeptide binding]; other site 588858009679 GSH binding site (G-site) [chemical binding]; other site 588858009680 dimer interface [polypeptide binding]; other site 588858009681 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 588858009682 dimer interface [polypeptide binding]; other site 588858009683 N-terminal domain interface [polypeptide binding]; other site 588858009684 active site 588858009685 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 588858009686 molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537 588858009687 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 588858009688 putative ligand binding residues [chemical binding]; other site 588858009689 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 588858009690 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 588858009691 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 588858009692 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 588858009693 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 588858009694 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 588858009695 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 588858009696 putative substrate-binding site; other site 588858009697 nickel binding site [ion binding]; other site 588858009698 hydrogenase 2 large subunit; Provisional; Region: PRK10467 588858009699 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 588858009700 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 588858009701 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 588858009702 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 588858009703 4Fe-4S binding domain; Region: Fer4_6; pfam12837 588858009704 hydrogenase 2 small subunit; Provisional; Region: PRK10468 588858009705 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 588858009706 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 588858009707 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 588858009708 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 588858009709 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 588858009710 dimerization interface [polypeptide binding]; other site 588858009711 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 588858009712 dimer interface [polypeptide binding]; other site 588858009713 putative CheW interface [polypeptide binding]; other site 588858009714 hypothetical protein; Provisional; Region: PRK05208 588858009715 oxidoreductase; Provisional; Region: PRK07985 588858009716 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 588858009717 NAD binding site [chemical binding]; other site 588858009718 metal binding site [ion binding]; metal-binding site 588858009719 active site 588858009720 biopolymer transport protein ExbD; Provisional; Region: PRK11267 588858009721 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 588858009722 biopolymer transport protein ExbB; Provisional; Region: PRK10414 588858009723 cystathionine beta-lyase; Provisional; Region: PRK08114 588858009724 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 588858009725 homodimer interface [polypeptide binding]; other site 588858009726 substrate-cofactor binding pocket; other site 588858009727 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858009728 catalytic residue [active] 588858009729 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 588858009730 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 588858009731 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 588858009732 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 588858009733 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 588858009734 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 588858009735 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 588858009736 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 588858009737 dimer interface [polypeptide binding]; other site 588858009738 active site 588858009739 metal binding site [ion binding]; metal-binding site 588858009740 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 588858009741 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 588858009742 active site 588858009743 catalytic tetrad [active] 588858009744 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 588858009745 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 588858009746 transmembrane helices; other site 588858009747 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 588858009748 nucleotide binding site/active site [active] 588858009749 catalytic residue [active] 588858009750 hypothetical protein; Provisional; Region: PRK01254 588858009751 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 588858009752 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 588858009753 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 588858009754 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 588858009755 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 588858009756 DctM-like transporters; Region: DctM; pfam06808 588858009757 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 588858009758 FtsI repressor; Provisional; Region: PRK10883 588858009759 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 588858009760 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 588858009761 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 588858009762 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 588858009763 putative acyl-acceptor binding pocket; other site 588858009764 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 588858009765 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 588858009766 CAP-like domain; other site 588858009767 active site 588858009768 primary dimer interface [polypeptide binding]; other site 588858009769 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 588858009770 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 588858009771 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 588858009772 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 588858009773 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 588858009774 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 588858009775 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 588858009776 active site 588858009777 phosphorylation site [posttranslational modification] 588858009778 intermolecular recognition site; other site 588858009779 dimerization interface [polypeptide binding]; other site 588858009780 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 588858009781 DNA binding site [nucleotide binding] 588858009782 sensor protein QseC; Provisional; Region: PRK10337 588858009783 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 588858009784 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 588858009785 dimer interface [polypeptide binding]; other site 588858009786 phosphorylation site [posttranslational modification] 588858009787 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 588858009788 ATP binding site [chemical binding]; other site 588858009789 Mg2+ binding site [ion binding]; other site 588858009790 G-X-G motif; other site 588858009791 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 588858009792 Uncharacterized conserved protein [Function unknown]; Region: COG1359 588858009793 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 588858009794 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 588858009795 ATP binding site [chemical binding]; other site 588858009796 Mg2+ binding site [ion binding]; other site 588858009797 G-X-G motif; other site 588858009798 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 588858009799 anchoring element; other site 588858009800 dimer interface [polypeptide binding]; other site 588858009801 ATP binding site [chemical binding]; other site 588858009802 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 588858009803 active site 588858009804 metal binding site [ion binding]; metal-binding site 588858009805 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 588858009806 esterase YqiA; Provisional; Region: PRK11071 588858009807 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 588858009808 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 588858009809 active site 588858009810 metal binding site [ion binding]; metal-binding site 588858009811 hexamer interface [polypeptide binding]; other site 588858009812 putative dehydrogenase; Provisional; Region: PRK11039 588858009813 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 588858009814 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 588858009815 dimer interface [polypeptide binding]; other site 588858009816 ADP-ribose binding site [chemical binding]; other site 588858009817 active site 588858009818 nudix motif; other site 588858009819 metal binding site [ion binding]; metal-binding site 588858009820 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 588858009821 hypothetical protein; Provisional; Region: PRK11653 588858009822 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 588858009823 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 588858009824 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 588858009825 putative active site [active] 588858009826 metal binding site [ion binding]; metal-binding site 588858009827 zinc transporter ZupT; Provisional; Region: PRK04201 588858009828 ZIP Zinc transporter; Region: Zip; pfam02535 588858009829 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 588858009830 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 588858009831 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 588858009832 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 588858009833 catalytic residues [active] 588858009834 hinge region; other site 588858009835 alpha helical domain; other site 588858009836 putative disulfide oxidoreductase; Provisional; Region: PRK04307 588858009837 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 588858009838 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 588858009839 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 588858009840 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 588858009841 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 588858009842 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 588858009843 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 588858009844 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 588858009845 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 588858009846 putative ribose interaction site [chemical binding]; other site 588858009847 putative ADP binding site [chemical binding]; other site 588858009848 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 588858009849 active site 588858009850 nucleotide binding site [chemical binding]; other site 588858009851 HIGH motif; other site 588858009852 KMSKS motif; other site 588858009853 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 588858009854 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 588858009855 metal binding triad; other site 588858009856 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 588858009857 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 588858009858 metal binding triad; other site 588858009859 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 588858009860 Uncharacterized conserved protein [Function unknown]; Region: COG3025 588858009861 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 588858009862 putative active site [active] 588858009863 putative metal binding residues [ion binding]; other site 588858009864 signature motif; other site 588858009865 putative triphosphate binding site [ion binding]; other site 588858009866 CHAD domain; Region: CHAD; pfam05235 588858009867 SH3 domain-containing protein; Provisional; Region: PRK10884 588858009868 Bacterial SH3 domain homologues; Region: SH3b; smart00287 588858009869 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 588858009870 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 588858009871 active site 588858009872 NTP binding site [chemical binding]; other site 588858009873 metal binding triad [ion binding]; metal-binding site 588858009874 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 588858009875 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 588858009876 Zn2+ binding site [ion binding]; other site 588858009877 Mg2+ binding site [ion binding]; other site 588858009878 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 588858009879 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 588858009880 homooctamer interface [polypeptide binding]; other site 588858009881 active site 588858009882 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 588858009883 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 588858009884 UGMP family protein; Validated; Region: PRK09604 588858009885 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 588858009886 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 588858009887 DNA primase; Validated; Region: dnaG; PRK05667 588858009888 CHC2 zinc finger; Region: zf-CHC2; pfam01807 588858009889 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 588858009890 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 588858009891 active site 588858009892 metal binding site [ion binding]; metal-binding site 588858009893 interdomain interaction site; other site 588858009894 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 588858009895 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 588858009896 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 588858009897 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 588858009898 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 588858009899 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 588858009900 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 588858009901 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 588858009902 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 588858009903 DNA binding residues [nucleotide binding] 588858009904 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 588858009905 active site 588858009906 SUMO-1 interface [polypeptide binding]; other site 588858009907 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 588858009908 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 588858009909 FAD binding pocket [chemical binding]; other site 588858009910 FAD binding motif [chemical binding]; other site 588858009911 phosphate binding motif [ion binding]; other site 588858009912 NAD binding pocket [chemical binding]; other site 588858009913 Predicted transcriptional regulators [Transcription]; Region: COG1695 588858009914 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 588858009915 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 588858009916 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 588858009917 dimerization interface [polypeptide binding]; other site 588858009918 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 588858009919 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 588858009920 dimer interface [polypeptide binding]; other site 588858009921 putative CheW interface [polypeptide binding]; other site 588858009922 PAS fold; Region: PAS_3; pfam08447 588858009923 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 588858009924 putative active site [active] 588858009925 heme pocket [chemical binding]; other site 588858009926 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 588858009927 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 588858009928 dimer interface [polypeptide binding]; other site 588858009929 putative CheW interface [polypeptide binding]; other site 588858009930 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 588858009931 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 588858009932 inhibitor-cofactor binding pocket; inhibition site 588858009933 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858009934 catalytic residue [active] 588858009935 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 588858009936 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 588858009937 active site 588858009938 FMN binding site [chemical binding]; other site 588858009939 2,4-decadienoyl-CoA binding site; other site 588858009940 catalytic residue [active] 588858009941 4Fe-4S cluster binding site [ion binding]; other site 588858009942 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 588858009943 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 588858009944 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 588858009945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 588858009946 S-adenosylmethionine binding site [chemical binding]; other site 588858009947 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 588858009948 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 588858009949 putative active site [active] 588858009950 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 588858009951 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 588858009952 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 588858009953 serine/threonine transporter SstT; Provisional; Region: PRK13628 588858009954 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 588858009955 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 588858009956 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 588858009957 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 588858009958 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 588858009959 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 588858009960 Predicted membrane protein [Function unknown]; Region: COG5393 588858009961 YqjK-like protein; Region: YqjK; pfam13997 588858009962 Predicted membrane protein [Function unknown]; Region: COG2259 588858009963 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 588858009964 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 588858009965 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 588858009966 putative dimer interface [polypeptide binding]; other site 588858009967 N-terminal domain interface [polypeptide binding]; other site 588858009968 putative substrate binding pocket (H-site) [chemical binding]; other site 588858009969 Predicted membrane protein [Function unknown]; Region: COG3152 588858009970 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858009971 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 588858009972 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 588858009973 dimerization interface [polypeptide binding]; other site 588858009974 Pirin-related protein [General function prediction only]; Region: COG1741 588858009975 Pirin; Region: Pirin; pfam02678 588858009976 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 588858009977 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 588858009978 serine transporter; Region: stp; TIGR00814 588858009979 L-serine dehydratase TdcG; Provisional; Region: PRK15040 588858009980 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 588858009981 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 588858009982 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 588858009983 Pyruvate formate lyase 1; Region: PFL1; cd01678 588858009984 coenzyme A binding site [chemical binding]; other site 588858009985 active site 588858009986 catalytic residues [active] 588858009987 glycine loop; other site 588858009988 propionate/acetate kinase; Provisional; Region: PRK12379 588858009989 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 588858009990 threonine/serine transporter TdcC; Provisional; Region: PRK13629 588858009991 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 588858009992 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 588858009993 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 588858009994 tetramer interface [polypeptide binding]; other site 588858009995 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858009996 catalytic residue [active] 588858009997 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 588858009998 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858009999 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 588858010000 putative substrate binding pocket [chemical binding]; other site 588858010001 putative dimerization interface [polypeptide binding]; other site 588858010002 glycerate kinase I; Provisional; Region: PRK10342 588858010003 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 588858010004 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 588858010005 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 588858010006 galactarate dehydratase; Region: galactar-dH20; TIGR03248 588858010007 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 588858010008 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 588858010009 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 588858010010 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 588858010011 substrate binding site [chemical binding]; other site 588858010012 ATP binding site [chemical binding]; other site 588858010013 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 588858010014 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 588858010015 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 588858010016 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 588858010017 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 588858010018 intersubunit interface [polypeptide binding]; other site 588858010019 active site 588858010020 zinc binding site [ion binding]; other site 588858010021 Na+ binding site [ion binding]; other site 588858010022 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 588858010023 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 588858010024 putative substrate binding site [chemical binding]; other site 588858010025 putative ATP binding site [chemical binding]; other site 588858010026 PTS system fructose-specific EIIBC component 588858010027 PTS family galactitol-specific enzyme IIC 588858010028 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 588858010029 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 588858010030 putative NAD(P) binding site [chemical binding]; other site 588858010031 catalytic Zn binding site [ion binding]; other site 588858010032 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 588858010033 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 588858010034 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 588858010035 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 588858010036 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 588858010037 putative SAM binding site [chemical binding]; other site 588858010038 putative homodimer interface [polypeptide binding]; other site 588858010039 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 588858010040 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 588858010041 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 588858010042 putative ligand binding site [chemical binding]; other site 588858010043 TIGR00252 family protein; Region: TIGR00252 588858010044 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 588858010045 dimer interface [polypeptide binding]; other site 588858010046 active site 588858010047 outer membrane lipoprotein; Provisional; Region: PRK11023 588858010048 BON domain; Region: BON; pfam04972 588858010049 BON domain; Region: BON; pfam04972 588858010050 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 588858010051 NADH(P)-binding; Region: NAD_binding_10; pfam13460 588858010052 NAD binding site [chemical binding]; other site 588858010053 active site 588858010054 intracellular protease, PfpI family; Region: PfpI; TIGR01382 588858010055 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 588858010056 proposed catalytic triad [active] 588858010057 conserved cys residue [active] 588858010058 hypothetical protein; Provisional; Region: PRK03467 588858010059 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 588858010060 GIY-YIG motif/motif A; other site 588858010061 putative active site [active] 588858010062 putative metal binding site [ion binding]; other site 588858010063 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 588858010064 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 588858010065 Coenzyme A binding pocket [chemical binding]; other site 588858010066 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 588858010067 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 588858010068 Peptidase family U32; Region: Peptidase_U32; pfam01136 588858010069 putative protease; Provisional; Region: PRK15447 588858010070 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 588858010071 hypothetical protein; Provisional; Region: PRK10508 588858010072 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 588858010073 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 588858010074 tryptophan permease; Provisional; Region: PRK10483 588858010075 aromatic amino acid transport protein; Region: araaP; TIGR00837 588858010076 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 588858010077 DEAD-like helicases superfamily; Region: DEXDc; smart00487 588858010078 ATP binding site [chemical binding]; other site 588858010079 Mg++ binding site [ion binding]; other site 588858010080 motif III; other site 588858010081 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 588858010082 nucleotide binding region [chemical binding]; other site 588858010083 ATP-binding site [chemical binding]; other site 588858010084 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 588858010085 putative RNA binding site [nucleotide binding]; other site 588858010086 lipoprotein NlpI; Provisional; Region: PRK11189 588858010087 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 588858010088 binding surface 588858010089 TPR motif; other site 588858010090 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 588858010091 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 588858010092 RNase E interface [polypeptide binding]; other site 588858010093 trimer interface [polypeptide binding]; other site 588858010094 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 588858010095 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 588858010096 RNase E interface [polypeptide binding]; other site 588858010097 trimer interface [polypeptide binding]; other site 588858010098 active site 588858010099 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 588858010100 putative nucleic acid binding region [nucleotide binding]; other site 588858010101 G-X-X-G motif; other site 588858010102 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 588858010103 RNA binding site [nucleotide binding]; other site 588858010104 domain interface; other site 588858010105 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 588858010106 16S/18S rRNA binding site [nucleotide binding]; other site 588858010107 S13e-L30e interaction site [polypeptide binding]; other site 588858010108 25S rRNA binding site [nucleotide binding]; other site 588858010109 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 588858010110 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 588858010111 RNA binding site [nucleotide binding]; other site 588858010112 active site 588858010113 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 588858010114 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 588858010115 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 588858010116 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 588858010117 translation initiation factor IF-2; Region: IF-2; TIGR00487 588858010118 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 588858010119 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 588858010120 G1 box; other site 588858010121 putative GEF interaction site [polypeptide binding]; other site 588858010122 GTP/Mg2+ binding site [chemical binding]; other site 588858010123 Switch I region; other site 588858010124 G2 box; other site 588858010125 G3 box; other site 588858010126 Switch II region; other site 588858010127 G4 box; other site 588858010128 G5 box; other site 588858010129 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 588858010130 Translation-initiation factor 2; Region: IF-2; pfam11987 588858010131 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 588858010132 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 588858010133 NusA N-terminal domain; Region: NusA_N; pfam08529 588858010134 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 588858010135 RNA binding site [nucleotide binding]; other site 588858010136 homodimer interface [polypeptide binding]; other site 588858010137 NusA-like KH domain; Region: KH_5; pfam13184 588858010138 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 588858010139 G-X-X-G motif; other site 588858010140 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 588858010141 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 588858010142 ribosome maturation protein RimP; Reviewed; Region: PRK00092 588858010143 Sm and related proteins; Region: Sm_like; cl00259 588858010144 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 588858010145 putative oligomer interface [polypeptide binding]; other site 588858010146 putative RNA binding site [nucleotide binding]; other site 588858010147 argininosuccinate synthase; Validated; Region: PRK05370 588858010148 argininosuccinate synthase; Provisional; Region: PRK13820 588858010149 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 588858010150 Preprotein translocase SecG subunit; Region: SecG; pfam03840 588858010151 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 588858010152 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 588858010153 active site 588858010154 substrate binding site [chemical binding]; other site 588858010155 metal binding site [ion binding]; metal-binding site 588858010156 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 588858010157 dihydropteroate synthase; Region: DHPS; TIGR01496 588858010158 substrate binding pocket [chemical binding]; other site 588858010159 dimer interface [polypeptide binding]; other site 588858010160 inhibitor binding site; inhibition site 588858010161 Transposase IS200 like; Region: Y1_Tnp; pfam01797 588858010162 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 588858010163 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 588858010164 Walker A motif; other site 588858010165 ATP binding site [chemical binding]; other site 588858010166 Walker B motif; other site 588858010167 arginine finger; other site 588858010168 Peptidase family M41; Region: Peptidase_M41; pfam01434 588858010169 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 588858010170 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 588858010171 S-adenosylmethionine binding site [chemical binding]; other site 588858010172 RNA-binding protein YhbY; Provisional; Region: PRK10343 588858010173 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 588858010174 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 588858010175 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 588858010176 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 588858010177 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 588858010178 GTPase CgtA; Reviewed; Region: obgE; PRK12298 588858010179 GTP1/OBG; Region: GTP1_OBG; pfam01018 588858010180 Obg GTPase; Region: Obg; cd01898 588858010181 G1 box; other site 588858010182 GTP/Mg2+ binding site [chemical binding]; other site 588858010183 Switch I region; other site 588858010184 G2 box; other site 588858010185 G3 box; other site 588858010186 Switch II region; other site 588858010187 G4 box; other site 588858010188 G5 box; other site 588858010189 pseudogene; frameshift relative to Escherichia coli b3184; yhhE 588858010190 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 588858010191 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 588858010192 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 588858010193 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 588858010194 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 588858010195 substrate binding pocket [chemical binding]; other site 588858010196 chain length determination region; other site 588858010197 substrate-Mg2+ binding site; other site 588858010198 catalytic residues [active] 588858010199 aspartate-rich region 1; other site 588858010200 active site lid residues [active] 588858010201 aspartate-rich region 2; other site 588858010202 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 588858010203 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 588858010204 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 588858010205 hinge; other site 588858010206 active site 588858010207 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 588858010208 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 588858010209 anti sigma factor interaction site; other site 588858010210 regulatory phosphorylation site [posttranslational modification]; other site 588858010211 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 588858010212 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 588858010213 mce related protein; Region: MCE; pfam02470 588858010214 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 588858010215 conserved hypothetical integral membrane protein; Region: TIGR00056 588858010216 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 588858010217 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 588858010218 Walker A/P-loop; other site 588858010219 ATP binding site [chemical binding]; other site 588858010220 Q-loop/lid; other site 588858010221 ABC transporter signature motif; other site 588858010222 Walker B; other site 588858010223 D-loop; other site 588858010224 H-loop/switch region; other site 588858010225 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 588858010226 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 588858010227 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 588858010228 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 588858010229 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 588858010230 putative active site [active] 588858010231 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 588858010232 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 588858010233 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 588858010234 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 588858010235 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 588858010236 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 588858010237 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 588858010238 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 588858010239 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 588858010240 Walker A/P-loop; other site 588858010241 ATP binding site [chemical binding]; other site 588858010242 Q-loop/lid; other site 588858010243 ABC transporter signature motif; other site 588858010244 Walker B; other site 588858010245 D-loop; other site 588858010246 H-loop/switch region; other site 588858010247 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 588858010248 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 588858010249 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 588858010250 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 588858010251 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 588858010252 30S subunit binding site; other site 588858010253 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 588858010254 active site 588858010255 phosphorylation site [posttranslational modification] 588858010256 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 588858010257 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 588858010258 dimerization domain swap beta strand [polypeptide binding]; other site 588858010259 regulatory protein interface [polypeptide binding]; other site 588858010260 active site 588858010261 regulatory phosphorylation site [posttranslational modification]; other site 588858010262 hypothetical protein; Provisional; Region: PRK10345 588858010263 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 588858010264 Transglycosylase; Region: Transgly; cl17702 588858010265 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 588858010266 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 588858010267 conserved cys residue [active] 588858010268 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 588858010269 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 588858010270 putative active site [active] 588858010271 heme pocket [chemical binding]; other site 588858010272 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 588858010273 dimer interface [polypeptide binding]; other site 588858010274 phosphorylation site [posttranslational modification] 588858010275 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 588858010276 ATP binding site [chemical binding]; other site 588858010277 Mg2+ binding site [ion binding]; other site 588858010278 G-X-G motif; other site 588858010279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 588858010280 active site 588858010281 phosphorylation site [posttranslational modification] 588858010282 intermolecular recognition site; other site 588858010283 dimerization interface [polypeptide binding]; other site 588858010284 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 588858010285 putative binding surface; other site 588858010286 active site 588858010287 radical SAM protein, TIGR01212 family; Region: TIGR01212 588858010288 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 588858010289 FeS/SAM binding site; other site 588858010290 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 588858010291 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 588858010292 active site 588858010293 dimer interface [polypeptide binding]; other site 588858010294 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 588858010295 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 588858010296 active site 588858010297 FMN binding site [chemical binding]; other site 588858010298 substrate binding site [chemical binding]; other site 588858010299 3Fe-4S cluster binding site [ion binding]; other site 588858010300 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 588858010301 domain interface; other site 588858010302 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 588858010303 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 588858010304 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 588858010305 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 588858010306 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 588858010307 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 588858010308 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 588858010309 Na binding site [ion binding]; other site 588858010310 putative substrate binding site [chemical binding]; other site 588858010311 cytosine deaminase; Provisional; Region: PRK09230 588858010312 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 588858010313 active site 588858010314 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 588858010315 N-acetylmannosamine kinase; Provisional; Region: PRK05082 588858010316 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 588858010317 nucleotide binding site [chemical binding]; other site 588858010318 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 588858010319 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 588858010320 putative active site cavity [active] 588858010321 putative sialic acid transporter; Provisional; Region: PRK03893 588858010322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858010323 putative substrate translocation pore; other site 588858010324 N-acetylneuraminate lyase; Provisional; Region: PRK04147 588858010325 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 588858010326 inhibitor site; inhibition site 588858010327 active site 588858010328 dimer interface [polypeptide binding]; other site 588858010329 catalytic residue [active] 588858010330 transcriptional regulator NanR; Provisional; Region: PRK03837 588858010331 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 588858010332 DNA-binding site [nucleotide binding]; DNA binding site 588858010333 FCD domain; Region: FCD; pfam07729 588858010334 Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969 588858010335 stringent starvation protein A; Provisional; Region: sspA; PRK09481 588858010336 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 588858010337 C-terminal domain interface [polypeptide binding]; other site 588858010338 putative GSH binding site (G-site) [chemical binding]; other site 588858010339 dimer interface [polypeptide binding]; other site 588858010340 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 588858010341 dimer interface [polypeptide binding]; other site 588858010342 N-terminal domain interface [polypeptide binding]; other site 588858010343 Family of unknown function (DUF695); Region: DUF695; pfam05117 588858010344 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 588858010345 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 588858010346 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 588858010347 23S rRNA interface [nucleotide binding]; other site 588858010348 L3 interface [polypeptide binding]; other site 588858010349 Predicted ATPase [General function prediction only]; Region: COG1485 588858010350 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 588858010351 hypothetical protein; Provisional; Region: PRK11677 588858010352 serine endoprotease; Provisional; Region: PRK10139 588858010353 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 588858010354 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 588858010355 protein binding site [polypeptide binding]; other site 588858010356 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 588858010357 serine endoprotease; Provisional; Region: PRK10898 588858010358 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 588858010359 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 588858010360 Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767 588858010361 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 588858010362 oxaloacetate decarboxylase; Provisional; Region: PRK14040 588858010363 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 588858010364 active site 588858010365 catalytic residues [active] 588858010366 metal binding site [ion binding]; metal-binding site 588858010367 homodimer binding site [polypeptide binding]; other site 588858010368 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 588858010369 carboxyltransferase (CT) interaction site; other site 588858010370 biotinylation site [posttranslational modification]; other site 588858010371 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 588858010372 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 588858010373 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 588858010374 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 588858010375 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 588858010376 transmembrane helices; other site 588858010377 Transcriptional regulators [Transcription]; Region: GntR; COG1802 588858010378 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 588858010379 DNA-binding site [nucleotide binding]; DNA binding site 588858010380 FCD domain; Region: FCD; pfam07729 588858010381 Transcriptional regulators [Transcription]; Region: GntR; COG1802 588858010382 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 588858010383 DNA-binding site [nucleotide binding]; DNA binding site 588858010384 malate dehydrogenase; Provisional; Region: PRK05086 588858010385 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 588858010386 NAD binding site [chemical binding]; other site 588858010387 dimerization interface [polypeptide binding]; other site 588858010388 Substrate binding site [chemical binding]; other site 588858010389 arginine repressor; Provisional; Region: PRK05066 588858010390 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 588858010391 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 588858010392 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 588858010393 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 588858010394 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 588858010395 RNAase interaction site [polypeptide binding]; other site 588858010396 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 588858010397 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 588858010398 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 588858010399 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 588858010400 HlyD family secretion protein; Region: HlyD_3; pfam13437 588858010401 efflux system membrane protein; Provisional; Region: PRK11594 588858010402 transcriptional regulator; Provisional; Region: PRK10632 588858010403 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858010404 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 588858010405 putative effector binding pocket; other site 588858010406 dimerization interface [polypeptide binding]; other site 588858010407 protease TldD; Provisional; Region: tldD; PRK10735 588858010408 hypothetical protein; Provisional; Region: PRK10899 588858010409 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 588858010410 ribonuclease G; Provisional; Region: PRK11712 588858010411 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 588858010412 homodimer interface [polypeptide binding]; other site 588858010413 oligonucleotide binding site [chemical binding]; other site 588858010414 Maf-like protein; Region: Maf; pfam02545 588858010415 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 588858010416 active site 588858010417 dimer interface [polypeptide binding]; other site 588858010418 rod shape-determining protein MreD; Provisional; Region: PRK11060 588858010419 rod shape-determining protein MreC; Region: mreC; TIGR00219 588858010420 rod shape-determining protein MreC; Region: MreC; pfam04085 588858010421 rod shape-determining protein MreB; Provisional; Region: PRK13927 588858010422 MreB and similar proteins; Region: MreB_like; cd10225 588858010423 nucleotide binding site [chemical binding]; other site 588858010424 Mg binding site [ion binding]; other site 588858010425 putative protofilament interaction site [polypeptide binding]; other site 588858010426 RodZ interaction site [polypeptide binding]; other site 588858010427 regulatory protein CsrD; Provisional; Region: PRK11059 588858010428 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 588858010429 metal binding site [ion binding]; metal-binding site 588858010430 active site 588858010431 I-site; other site 588858010432 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 588858010433 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 588858010434 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 588858010435 NADP binding site [chemical binding]; other site 588858010436 dimer interface [polypeptide binding]; other site 588858010437 TMAO/DMSO reductase; Reviewed; Region: PRK05363 588858010438 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 588858010439 Moco binding site; other site 588858010440 metal coordination site [ion binding]; other site 588858010441 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 588858010442 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 588858010443 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 588858010444 carboxyltransferase (CT) interaction site; other site 588858010445 biotinylation site [posttranslational modification]; other site 588858010446 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 588858010447 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 588858010448 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 588858010449 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 588858010450 hypothetical protein; Provisional; Region: PRK10633 588858010451 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 588858010452 Na binding site [ion binding]; other site 588858010453 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 588858010454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 588858010455 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 588858010456 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 588858010457 FMN binding site [chemical binding]; other site 588858010458 active site 588858010459 catalytic residues [active] 588858010460 substrate binding site [chemical binding]; other site 588858010461 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 588858010462 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 588858010463 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 588858010464 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 588858010465 DNA methylase; Region: N6_N4_Mtase; pfam01555 588858010466 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 588858010467 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 588858010468 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 588858010469 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 588858010470 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 588858010471 metal binding site [ion binding]; metal-binding site 588858010472 active site 588858010473 I-site; other site 588858010474 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 588858010475 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 588858010476 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 588858010477 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 588858010478 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 588858010479 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 588858010480 HlyD family secretion protein; Region: HlyD_3; pfam13437 588858010481 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 588858010482 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 588858010483 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 588858010484 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 588858010485 trimer interface [polypeptide binding]; other site 588858010486 putative metal binding site [ion binding]; other site 588858010487 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 588858010488 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 588858010489 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 588858010490 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 588858010491 shikimate binding site; other site 588858010492 NAD(P) binding site [chemical binding]; other site 588858010493 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 588858010494 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 588858010495 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 588858010496 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 588858010497 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 588858010498 hypothetical protein; Validated; Region: PRK03430 588858010499 hypothetical protein; Provisional; Region: PRK10736 588858010500 DNA protecting protein DprA; Region: dprA; TIGR00732 588858010501 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 588858010502 active site 588858010503 catalytic residues [active] 588858010504 metal binding site [ion binding]; metal-binding site 588858010505 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 588858010506 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 588858010507 putative active site [active] 588858010508 substrate binding site [chemical binding]; other site 588858010509 putative cosubstrate binding site; other site 588858010510 catalytic site [active] 588858010511 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 588858010512 substrate binding site [chemical binding]; other site 588858010513 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 588858010514 putative RNA binding site [nucleotide binding]; other site 588858010515 16S rRNA methyltransferase B; Provisional; Region: PRK10901 588858010516 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 588858010517 S-adenosylmethionine binding site [chemical binding]; other site 588858010518 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 588858010519 TrkA-N domain; Region: TrkA_N; pfam02254 588858010520 TrkA-C domain; Region: TrkA_C; pfam02080 588858010521 TrkA-N domain; Region: TrkA_N; pfam02254 588858010522 TrkA-C domain; Region: TrkA_C; pfam02080 588858010523 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 588858010524 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 588858010525 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 588858010526 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 588858010527 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 588858010528 DNA binding residues [nucleotide binding] 588858010529 dimer interface [polypeptide binding]; other site 588858010530 metal binding site [ion binding]; metal-binding site 588858010531 hypothetical protein; Provisional; Region: PRK10203 588858010532 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 588858010533 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 588858010534 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 588858010535 alphaNTD homodimer interface [polypeptide binding]; other site 588858010536 alphaNTD - beta interaction site [polypeptide binding]; other site 588858010537 alphaNTD - beta' interaction site [polypeptide binding]; other site 588858010538 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 588858010539 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 588858010540 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 588858010541 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 588858010542 RNA binding surface [nucleotide binding]; other site 588858010543 30S ribosomal protein S11; Validated; Region: PRK05309 588858010544 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 588858010545 30S ribosomal protein S13; Region: bact_S13; TIGR03631 588858010546 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 588858010547 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 588858010548 SecY translocase; Region: SecY; pfam00344 588858010549 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 588858010550 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 588858010551 23S rRNA binding site [nucleotide binding]; other site 588858010552 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 588858010553 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 588858010554 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 588858010555 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 588858010556 23S rRNA interface [nucleotide binding]; other site 588858010557 5S rRNA interface [nucleotide binding]; other site 588858010558 L27 interface [polypeptide binding]; other site 588858010559 L5 interface [polypeptide binding]; other site 588858010560 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 588858010561 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 588858010562 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 588858010563 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 588858010564 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 588858010565 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 588858010566 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 588858010567 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 588858010568 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 588858010569 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 588858010570 RNA binding site [nucleotide binding]; other site 588858010571 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 588858010572 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 588858010573 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 588858010574 23S rRNA interface [nucleotide binding]; other site 588858010575 putative translocon interaction site; other site 588858010576 signal recognition particle (SRP54) interaction site; other site 588858010577 L23 interface [polypeptide binding]; other site 588858010578 trigger factor interaction site; other site 588858010579 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 588858010580 23S rRNA interface [nucleotide binding]; other site 588858010581 5S rRNA interface [nucleotide binding]; other site 588858010582 putative antibiotic binding site [chemical binding]; other site 588858010583 L25 interface [polypeptide binding]; other site 588858010584 L27 interface [polypeptide binding]; other site 588858010585 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 588858010586 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 588858010587 G-X-X-G motif; other site 588858010588 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 588858010589 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 588858010590 protein-rRNA interface [nucleotide binding]; other site 588858010591 putative translocon binding site; other site 588858010592 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 588858010593 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 588858010594 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 588858010595 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 588858010596 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 588858010597 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 588858010598 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 588858010599 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 588858010600 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 588858010601 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 588858010602 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 588858010603 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 588858010604 heme binding site [chemical binding]; other site 588858010605 ferroxidase pore; other site 588858010606 ferroxidase diiron center [ion binding]; other site 588858010607 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 588858010608 elongation factor Tu; Reviewed; Region: PRK00049 588858010609 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 588858010610 G1 box; other site 588858010611 GEF interaction site [polypeptide binding]; other site 588858010612 GTP/Mg2+ binding site [chemical binding]; other site 588858010613 Switch I region; other site 588858010614 G2 box; other site 588858010615 G3 box; other site 588858010616 Switch II region; other site 588858010617 G4 box; other site 588858010618 G5 box; other site 588858010619 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 588858010620 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 588858010621 Antibiotic Binding Site [chemical binding]; other site 588858010622 elongation factor G; Reviewed; Region: PRK00007 588858010623 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 588858010624 G1 box; other site 588858010625 putative GEF interaction site [polypeptide binding]; other site 588858010626 GTP/Mg2+ binding site [chemical binding]; other site 588858010627 Switch I region; other site 588858010628 G2 box; other site 588858010629 G3 box; other site 588858010630 Switch II region; other site 588858010631 G4 box; other site 588858010632 G5 box; other site 588858010633 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 588858010634 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 588858010635 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 588858010636 30S ribosomal protein S7; Validated; Region: PRK05302 588858010637 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 588858010638 S17 interaction site [polypeptide binding]; other site 588858010639 S8 interaction site; other site 588858010640 16S rRNA interaction site [nucleotide binding]; other site 588858010641 streptomycin interaction site [chemical binding]; other site 588858010642 23S rRNA interaction site [nucleotide binding]; other site 588858010643 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 588858010644 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 588858010645 sulfur relay protein TusC; Validated; Region: PRK00211 588858010646 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 588858010647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 588858010648 YheO-like PAS domain; Region: PAS_6; pfam08348 588858010649 HTH domain; Region: HTH_22; pfam13309 588858010650 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 588858010651 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 588858010652 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 588858010653 phi X174 lysis protein; Provisional; Region: PRK02793 588858010654 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 588858010655 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 588858010656 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 588858010657 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 588858010658 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 588858010659 TrkA-N domain; Region: TrkA_N; pfam02254 588858010660 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 588858010661 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 588858010662 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 588858010663 Walker A/P-loop; other site 588858010664 ATP binding site [chemical binding]; other site 588858010665 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 588858010666 ABC transporter signature motif; other site 588858010667 Walker B; other site 588858010668 D-loop; other site 588858010669 ABC transporter; Region: ABC_tran_2; pfam12848 588858010670 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 588858010671 pseudogene; in-frame stop following codon 15 588858010672 putative monooxygenase; Provisional; Region: PRK11118 588858010673 putative hydrolase; Provisional; Region: PRK10985 588858010674 SAM (Sterile alpha motif ); Region: SAM_superfamily; cl15755 588858010675 hypothetical protein; Provisional; Region: PRK04966 588858010676 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 588858010677 active site 588858010678 hypothetical protein; Provisional; Region: PRK10738 588858010679 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 588858010680 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 588858010681 ligand binding site [chemical binding]; other site 588858010682 flexible hinge region; other site 588858010683 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 588858010684 putative switch regulator; other site 588858010685 non-specific DNA interactions [nucleotide binding]; other site 588858010686 DNA binding site [nucleotide binding] 588858010687 sequence specific DNA binding site [nucleotide binding]; other site 588858010688 putative cAMP binding site [chemical binding]; other site 588858010689 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 588858010690 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 588858010691 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 588858010692 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 588858010693 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 588858010694 inhibitor-cofactor binding pocket; inhibition site 588858010695 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858010696 catalytic residue [active] 588858010697 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 588858010698 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 588858010699 glutamine binding [chemical binding]; other site 588858010700 catalytic triad [active] 588858010701 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 588858010702 cell filamentation protein Fic; Provisional; Region: PRK10347 588858010703 hypothetical protein; Provisional; Region: PRK10204 588858010704 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 588858010705 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 588858010706 substrate binding site [chemical binding]; other site 588858010707 putative transporter; Provisional; Region: PRK03699 588858010708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858010709 putative substrate translocation pore; other site 588858010710 nitrite reductase subunit NirD; Provisional; Region: PRK14989 588858010711 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 588858010712 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 588858010713 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 588858010714 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 588858010715 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 588858010716 nitrite transporter NirC; Provisional; Region: PRK11562 588858010717 siroheme synthase; Provisional; Region: cysG; PRK10637 588858010718 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 588858010719 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 588858010720 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 588858010721 active site 588858010722 SAM binding site [chemical binding]; other site 588858010723 homodimer interface [polypeptide binding]; other site 588858010724 Autotransporter beta-domain; Region: Autotransporter; pfam03797 588858010725 Transposase IS200 like; Region: Y1_Tnp; pfam01797 588858010726 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 588858010727 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 588858010728 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 588858010729 active site 588858010730 HIGH motif; other site 588858010731 dimer interface [polypeptide binding]; other site 588858010732 KMSKS motif; other site 588858010733 phosphoglycolate phosphatase; Provisional; Region: PRK13222 588858010734 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 588858010735 motif II; other site 588858010736 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 588858010737 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 588858010738 substrate binding site [chemical binding]; other site 588858010739 hexamer interface [polypeptide binding]; other site 588858010740 metal binding site [ion binding]; metal-binding site 588858010741 DNA adenine methylase; Provisional; Region: PRK10904 588858010742 cell division protein DamX; Validated; Region: PRK10905 588858010743 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 588858010744 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 588858010745 active site 588858010746 dimer interface [polypeptide binding]; other site 588858010747 metal binding site [ion binding]; metal-binding site 588858010748 shikimate kinase; Reviewed; Region: aroK; PRK00131 588858010749 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 588858010750 ADP binding site [chemical binding]; other site 588858010751 magnesium binding site [ion binding]; other site 588858010752 putative shikimate binding site; other site 588858010753 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 588858010754 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 588858010755 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 588858010756 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 588858010757 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 588858010758 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 588858010759 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 588858010760 Transglycosylase; Region: Transgly; pfam00912 588858010761 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 588858010762 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 588858010763 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 588858010764 ADP-ribose binding site [chemical binding]; other site 588858010765 dimer interface [polypeptide binding]; other site 588858010766 active site 588858010767 nudix motif; other site 588858010768 metal binding site [ion binding]; metal-binding site 588858010769 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 588858010770 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 588858010771 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 588858010772 motif II; other site 588858010773 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 588858010774 RNA binding surface [nucleotide binding]; other site 588858010775 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 588858010776 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 588858010777 dimerization interface [polypeptide binding]; other site 588858010778 domain crossover interface; other site 588858010779 redox-dependent activation switch; other site 588858010780 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 588858010781 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 588858010782 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 588858010783 active site 588858010784 substrate-binding site [chemical binding]; other site 588858010785 metal-binding site [ion binding] 588858010786 ATP binding site [chemical binding]; other site 588858010787 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 588858010788 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 588858010789 dimerization interface [polypeptide binding]; other site 588858010790 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 588858010791 dimer interface [polypeptide binding]; other site 588858010792 phosphorylation site [posttranslational modification] 588858010793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 588858010794 ATP binding site [chemical binding]; other site 588858010795 G-X-G motif; other site 588858010796 osmolarity response regulator; Provisional; Region: ompR; PRK09468 588858010797 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 588858010798 active site 588858010799 phosphorylation site [posttranslational modification] 588858010800 intermolecular recognition site; other site 588858010801 dimerization interface [polypeptide binding]; other site 588858010802 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 588858010803 DNA binding site [nucleotide binding] 588858010804 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 588858010805 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 588858010806 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 588858010807 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 588858010808 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 588858010809 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 588858010810 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 588858010811 RNA binding site [nucleotide binding]; other site 588858010812 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 588858010813 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 588858010814 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 588858010815 G1 box; other site 588858010816 GTP/Mg2+ binding site [chemical binding]; other site 588858010817 Switch I region; other site 588858010818 G2 box; other site 588858010819 G3 box; other site 588858010820 Switch II region; other site 588858010821 G4 box; other site 588858010822 G5 box; other site 588858010823 Nucleoside recognition; Region: Gate; pfam07670 588858010824 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 588858010825 Nucleoside recognition; Region: Gate; pfam07670 588858010826 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 588858010827 hypothetical protein; Provisional; Region: PRK09956 588858010828 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 588858010829 carboxylesterase BioH; Provisional; Region: PRK10349 588858010830 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 588858010831 DNA utilization protein GntX; Provisional; Region: PRK11595 588858010832 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 588858010833 active site 588858010834 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 588858010835 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 588858010836 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 588858010837 high-affinity gluconate transporter; Provisional; Region: PRK14984 588858010838 gluconate transporter; Region: gntP; TIGR00791 588858010839 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 588858010840 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 588858010841 maltodextrin phosphorylase; Provisional; Region: PRK14985 588858010842 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 588858010843 homodimer interface [polypeptide binding]; other site 588858010844 active site pocket [active] 588858010845 transcriptional regulator MalT; Provisional; Region: PRK04841 588858010846 AAA ATPase domain; Region: AAA_16; pfam13191 588858010847 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 588858010848 DNA binding residues [nucleotide binding] 588858010849 dimerization interface [polypeptide binding]; other site 588858010850 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 588858010851 DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077 588858010852 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 588858010853 RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874 588858010854 putative active site [active] 588858010855 adenylation catalytic residue [active] 588858010856 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 588858010857 hypothetical protein; Reviewed; Region: PRK09588 588858010858 TROVE domain; Region: TROVE; pfam05731 588858010859 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 588858010860 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 588858010861 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 588858010862 Walker A motif; other site 588858010863 ATP binding site [chemical binding]; other site 588858010864 Walker B motif; other site 588858010865 arginine finger; other site 588858010866 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 588858010867 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 588858010868 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 588858010869 intramembrane serine protease GlpG; Provisional; Region: PRK10907 588858010870 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 588858010871 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 588858010872 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 588858010873 active site residue [active] 588858010874 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 588858010875 hypothetical protein; Provisional; Region: PRK09781 588858010876 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 588858010877 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 588858010878 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 588858010879 dimer interface [polypeptide binding]; other site 588858010880 active site 588858010881 metal binding site [ion binding]; metal-binding site 588858010882 pseudogene; frameshift; putative permease 588858010883 Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism / Carbohydrate transport and metabolism]; Region: IlvD; COG0129 588858010884 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 588858010885 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 588858010886 inhibitor site; inhibition site 588858010887 active site 588858010888 dimer interface [polypeptide binding]; other site 588858010889 catalytic residue [active] 588858010890 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 588858010891 Transcriptional regulator [Transcription]; Region: IclR; COG1414 588858010892 Bacterial transcriptional regulator; Region: IclR; pfam01614 588858010893 glycogen phosphorylase; Provisional; Region: PRK14986 588858010894 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 588858010895 homodimer interface [polypeptide binding]; other site 588858010896 active site pocket [active] 588858010897 glycogen synthase; Provisional; Region: glgA; PRK00654 588858010898 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 588858010899 ADP-binding pocket [chemical binding]; other site 588858010900 homodimer interface [polypeptide binding]; other site 588858010901 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 588858010902 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 588858010903 ligand binding site; other site 588858010904 oligomer interface; other site 588858010905 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 588858010906 dimer interface [polypeptide binding]; other site 588858010907 N-terminal domain interface [polypeptide binding]; other site 588858010908 sulfate 1 binding site; other site 588858010909 glycogen debranching enzyme; Provisional; Region: PRK03705 588858010910 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 588858010911 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 588858010912 active site 588858010913 catalytic site [active] 588858010914 glycogen branching enzyme; Provisional; Region: PRK05402 588858010915 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 588858010916 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 588858010917 active site 588858010918 catalytic site [active] 588858010919 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 588858010920 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 588858010921 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 588858010922 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 588858010923 low affinity gluconate transporter; Provisional; Region: PRK10472 588858010924 gluconate transporter; Region: gntP; TIGR00791 588858010925 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 588858010926 ATP-binding site [chemical binding]; other site 588858010927 Gluconate-6-phosphate binding site [chemical binding]; other site 588858010928 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 588858010929 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 588858010930 DNA binding site [nucleotide binding] 588858010931 domain linker motif; other site 588858010932 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 588858010933 putative ligand binding site [chemical binding]; other site 588858010934 putative dimerization interface [polypeptide binding]; other site 588858010935 Pirin-related protein [General function prediction only]; Region: COG1741 588858010936 Pirin; Region: Pirin; pfam02678 588858010937 putative oxidoreductase; Provisional; Region: PRK10206 588858010938 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 588858010939 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 588858010940 putative acetyltransferase YhhY; Provisional; Region: PRK10140 588858010941 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 588858010942 Coenzyme A binding pocket [chemical binding]; other site 588858010943 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 588858010944 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 588858010945 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 588858010946 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 588858010947 substrate binding site [chemical binding]; other site 588858010948 dimer interface [polypeptide binding]; other site 588858010949 ATP binding site [chemical binding]; other site 588858010950 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 588858010951 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 588858010952 Protein of unknown function, DUF606; Region: DUF606; pfam04657 588858010953 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 588858010954 active site 588858010955 substrate binding pocket [chemical binding]; other site 588858010956 homodimer interaction site [polypeptide binding]; other site 588858010957 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 588858010958 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 588858010959 hypothetical protein; Provisional; Region: PRK10350 588858010960 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 588858010961 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 588858010962 putative active site [active] 588858010963 catalytic site [active] 588858010964 putative metal binding site [ion binding]; other site 588858010965 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 588858010966 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 588858010967 Walker A/P-loop; other site 588858010968 ATP binding site [chemical binding]; other site 588858010969 Q-loop/lid; other site 588858010970 ABC transporter signature motif; other site 588858010971 Walker B; other site 588858010972 D-loop; other site 588858010973 H-loop/switch region; other site 588858010974 TOBE domain; Region: TOBE_2; pfam08402 588858010975 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 588858010976 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858010977 dimer interface [polypeptide binding]; other site 588858010978 conserved gate region; other site 588858010979 ABC-ATPase subunit interface; other site 588858010980 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 588858010981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858010982 dimer interface [polypeptide binding]; other site 588858010983 conserved gate region; other site 588858010984 putative PBP binding loops; other site 588858010985 ABC-ATPase subunit interface; other site 588858010986 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 588858010987 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 588858010988 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 588858010989 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 588858010990 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 588858010991 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 588858010992 Walker A/P-loop; other site 588858010993 ATP binding site [chemical binding]; other site 588858010994 Q-loop/lid; other site 588858010995 ABC transporter signature motif; other site 588858010996 Walker B; other site 588858010997 D-loop; other site 588858010998 H-loop/switch region; other site 588858010999 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 588858011000 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 588858011001 Walker A/P-loop; other site 588858011002 ATP binding site [chemical binding]; other site 588858011003 Q-loop/lid; other site 588858011004 ABC transporter signature motif; other site 588858011005 Walker B; other site 588858011006 D-loop; other site 588858011007 H-loop/switch region; other site 588858011008 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 588858011009 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 588858011010 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 588858011011 TM-ABC transporter signature motif; other site 588858011012 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 588858011013 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 588858011014 TM-ABC transporter signature motif; other site 588858011015 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 588858011016 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 588858011017 dimerization interface [polypeptide binding]; other site 588858011018 ligand binding site [chemical binding]; other site 588858011019 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 588858011020 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 588858011021 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 588858011022 dimerization interface [polypeptide binding]; other site 588858011023 ligand binding site [chemical binding]; other site 588858011024 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 588858011025 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 588858011026 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 588858011027 DNA binding residues [nucleotide binding] 588858011028 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 588858011029 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 588858011030 cell division protein FtsE; Provisional; Region: PRK10908 588858011031 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 588858011032 Walker A/P-loop; other site 588858011033 ATP binding site [chemical binding]; other site 588858011034 Q-loop/lid; other site 588858011035 ABC transporter signature motif; other site 588858011036 Walker B; other site 588858011037 D-loop; other site 588858011038 H-loop/switch region; other site 588858011039 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 588858011040 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 588858011041 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 588858011042 P loop; other site 588858011043 GTP binding site [chemical binding]; other site 588858011044 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 588858011045 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 588858011046 S-adenosylmethionine binding site [chemical binding]; other site 588858011047 hypothetical protein; Provisional; Region: PRK10910 588858011048 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 588858011049 Predicted membrane protein [Function unknown]; Region: COG3714 588858011050 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 588858011051 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 588858011052 metal-binding site [ion binding] 588858011053 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 588858011054 Soluble P-type ATPase [General function prediction only]; Region: COG4087 588858011055 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 588858011056 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 588858011057 dimer interface [polypeptide binding]; other site 588858011058 ligand binding site [chemical binding]; other site 588858011059 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 588858011060 dimerization interface [polypeptide binding]; other site 588858011061 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 588858011062 dimer interface [polypeptide binding]; other site 588858011063 putative CheW interface [polypeptide binding]; other site 588858011064 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 588858011065 CPxP motif; other site 588858011066 hypothetical protein; Provisional; Region: PRK11212 588858011067 hypothetical protein; Provisional; Region: PRK11615 588858011068 major facilitator superfamily transporter; Provisional; Region: PRK05122 588858011069 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858011070 putative substrate translocation pore; other site 588858011071 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 588858011072 Domain of unknown function DUF20; Region: UPF0118; pfam01594 588858011073 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 588858011074 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 588858011075 nickel responsive regulator; Provisional; Region: PRK02967 588858011076 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 588858011077 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 588858011078 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 588858011079 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 588858011080 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 588858011081 Walker A/P-loop; other site 588858011082 ATP binding site [chemical binding]; other site 588858011083 Q-loop/lid; other site 588858011084 ABC transporter signature motif; other site 588858011085 Walker B; other site 588858011086 D-loop; other site 588858011087 H-loop/switch region; other site 588858011088 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 588858011089 Walker A/P-loop; other site 588858011090 ATP binding site [chemical binding]; other site 588858011091 Q-loop/lid; other site 588858011092 ABC transporter signature motif; other site 588858011093 Walker B; other site 588858011094 D-loop; other site 588858011095 H-loop/switch region; other site 588858011096 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 588858011097 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 588858011098 HlyD family secretion protein; Region: HlyD; pfam00529 588858011099 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 588858011100 HlyD family secretion protein; Region: HlyD_3; pfam13437 588858011101 Predicted flavoproteins [General function prediction only]; Region: COG2081 588858011102 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 588858011103 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 588858011104 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 588858011105 universal stress protein UspB; Provisional; Region: PRK04960 588858011106 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 588858011107 Ligand Binding Site [chemical binding]; other site 588858011108 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 588858011109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858011110 putative substrate translocation pore; other site 588858011111 POT family; Region: PTR2; pfam00854 588858011112 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 588858011113 S-adenosylmethionine binding site [chemical binding]; other site 588858011114 oligopeptidase A; Provisional; Region: PRK10911 588858011115 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 588858011116 active site 588858011117 Zn binding site [ion binding]; other site 588858011118 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 588858011119 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 588858011120 active site 588858011121 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 588858011122 glutathione reductase; Validated; Region: PRK06116 588858011123 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 588858011124 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 588858011125 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 588858011126 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 588858011127 active site 588858011128 homodimer interface [polypeptide binding]; other site 588858011129 homotetramer interface [polypeptide binding]; other site 588858011130 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 588858011131 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 588858011132 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 588858011133 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 588858011134 substrate binding site [chemical binding]; other site 588858011135 ATP binding site [chemical binding]; other site 588858011136 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 588858011137 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 588858011138 putative active site [active] 588858011139 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 588858011140 dimer interface [polypeptide binding]; other site 588858011141 active site 588858011142 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 588858011143 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 588858011144 DNA-binding site [nucleotide binding]; DNA binding site 588858011145 UTRA domain; Region: UTRA; pfam07702 588858011146 trehalase; Provisional; Region: treF; PRK13270 588858011147 Trehalase; Region: Trehalase; pfam01204 588858011148 Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772 588858011149 catalytic residue [active] 588858011150 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 588858011151 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 588858011152 DNA binding residues [nucleotide binding] 588858011153 dimerization interface [polypeptide binding]; other site 588858011154 Transcriptional regulator [Transcription]; Region: LysR; COG0583 588858011155 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858011156 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 588858011157 putative effector binding pocket; other site 588858011158 putative dimerization interface [polypeptide binding]; other site 588858011159 inner membrane protein YhjD; Region: TIGR00766 588858011160 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858011161 metabolite-proton symporter; Region: 2A0106; TIGR00883 588858011162 putative substrate translocation pore; other site 588858011163 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 588858011164 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 588858011165 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 588858011166 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 588858011167 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 588858011168 substrate binding site [chemical binding]; other site 588858011169 ATP binding site [chemical binding]; other site 588858011170 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 588858011171 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 588858011172 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 588858011173 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 588858011174 putative diguanylate cyclase; Provisional; Region: PRK13561 588858011175 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 588858011176 metal binding site [ion binding]; metal-binding site 588858011177 active site 588858011178 I-site; other site 588858011179 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 588858011180 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 588858011181 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 588858011182 TPR motif; other site 588858011183 binding surface 588858011184 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 588858011185 TPR motif; other site 588858011186 binding surface 588858011187 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 588858011188 binding surface 588858011189 TPR motif; other site 588858011190 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 588858011191 endo-1,4-D-glucanase; Provisional; Region: PRK11097 588858011192 cellulose synthase regulator protein; Provisional; Region: PRK11114 588858011193 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 588858011194 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 588858011195 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 588858011196 DXD motif; other site 588858011197 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 588858011198 PilZ domain; Region: PilZ; pfam07238 588858011199 cell division protein; Provisional; Region: PRK10037 588858011200 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 588858011201 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 588858011202 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 588858011203 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 588858011204 cellulose synthase operon protein YhjU; Region: cellulose_yhjU; TIGR03368 588858011205 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 588858011206 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 588858011207 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 588858011208 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 588858011209 Walker A/P-loop; other site 588858011210 ATP binding site [chemical binding]; other site 588858011211 Q-loop/lid; other site 588858011212 ABC transporter signature motif; other site 588858011213 Walker B; other site 588858011214 D-loop; other site 588858011215 H-loop/switch region; other site 588858011216 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 588858011217 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 588858011218 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 588858011219 Walker A/P-loop; other site 588858011220 ATP binding site [chemical binding]; other site 588858011221 Q-loop/lid; other site 588858011222 ABC transporter signature motif; other site 588858011223 Walker B; other site 588858011224 D-loop; other site 588858011225 H-loop/switch region; other site 588858011226 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 588858011227 dipeptide transporter; Provisional; Region: PRK10913 588858011228 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 588858011229 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858011230 dimer interface [polypeptide binding]; other site 588858011231 conserved gate region; other site 588858011232 putative PBP binding loops; other site 588858011233 ABC-ATPase subunit interface; other site 588858011234 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 588858011235 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858011236 dimer interface [polypeptide binding]; other site 588858011237 conserved gate region; other site 588858011238 putative PBP binding loops; other site 588858011239 ABC-ATPase subunit interface; other site 588858011240 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 588858011241 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 588858011242 peptide binding site [polypeptide binding]; other site 588858011243 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 588858011244 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 588858011245 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 588858011246 Transcriptional regulators [Transcription]; Region: PurR; COG1609 588858011247 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 588858011248 DNA binding site [nucleotide binding] 588858011249 domain linker motif; other site 588858011250 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_8; cd06287 588858011251 putative dimerization interface [polypeptide binding]; other site 588858011252 putative ligand binding site [chemical binding]; other site 588858011253 phosphoethanolamine transferase; Provisional; Region: PRK11560 588858011254 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 588858011255 Sulfatase; Region: Sulfatase; pfam00884 588858011256 long polar fimbrial protein LpfE; Provisional; Region: PRK15205 588858011257 LpfD protein precursor (SW:LPFD_SALTY); disrupted by frameshift 588858011258 long polar fimbrial outer membrane usher protein LpfC; Provisional; Region: PRK15207 588858011259 PapC N-terminal domain; Region: PapC_N; pfam13954 588858011260 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 588858011261 PapC C-terminal domain; Region: PapC_C; pfam13953 588858011262 long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208 588858011263 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 588858011264 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 588858011265 long polar fimbrial protein LpfA; Provisional; Region: PRK15209 588858011266 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 588858011267 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 588858011268 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 588858011269 Coenzyme A binding pocket [chemical binding]; other site 588858011270 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 588858011271 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 588858011272 molybdopterin cofactor binding site [chemical binding]; other site 588858011273 substrate binding site [chemical binding]; other site 588858011274 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 588858011275 molybdopterin cofactor binding site; other site 588858011276 putative outer membrane lipoprotein; Provisional; Region: PRK10510 588858011277 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 588858011278 ligand binding site [chemical binding]; other site 588858011279 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 588858011280 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 588858011281 dimerization interface [polypeptide binding]; other site 588858011282 ligand binding site [chemical binding]; other site 588858011283 NADP binding site [chemical binding]; other site 588858011284 catalytic site [active] 588858011285 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 588858011286 Predicted transcriptional regulator [Transcription]; Region: COG2944 588858011287 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 588858011288 salt bridge; other site 588858011289 non-specific DNA binding site [nucleotide binding]; other site 588858011290 sequence-specific DNA binding site [nucleotide binding]; other site 588858011291 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 588858011292 DNA-binding site [nucleotide binding]; DNA binding site 588858011293 RNA-binding motif; other site 588858011294 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 588858011295 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 588858011296 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 588858011297 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 588858011298 Coenzyme A binding pocket [chemical binding]; other site 588858011299 pseudogene; in-frame stop following codon 23 588858011300 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 588858011301 DALR anticodon binding domain; Region: DALR_1; pfam05746 588858011302 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 588858011303 dimer interface [polypeptide binding]; other site 588858011304 motif 1; other site 588858011305 active site 588858011306 motif 2; other site 588858011307 motif 3; other site 588858011308 YsaB-like lipoprotein; Region: YsaB; pfam13983 588858011309 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 588858011310 Acyltransferase family; Region: Acyl_transf_3; pfam01757 588858011311 Predicted membrane protein [Function unknown]; Region: COG4682 588858011312 yiaA/B two helix domain; Region: YiaAB; cl01759 588858011313 yiaA/B two helix domain; Region: YiaAB; cl01759 588858011314 xylulokinase; Provisional; Region: PRK15027 588858011315 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 588858011316 N- and C-terminal domain interface [polypeptide binding]; other site 588858011317 active site 588858011318 MgATP binding site [chemical binding]; other site 588858011319 catalytic site [active] 588858011320 metal binding site [ion binding]; metal-binding site 588858011321 xylulose binding site [chemical binding]; other site 588858011322 homodimer interface [polypeptide binding]; other site 588858011323 xylose isomerase; Provisional; Region: PRK05474 588858011324 xylose isomerase; Region: xylose_isom_A; TIGR02630 588858011325 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 588858011326 putative dimerization interface [polypeptide binding]; other site 588858011327 Transcriptional regulators [Transcription]; Region: PurR; COG1609 588858011328 putative ligand binding site [chemical binding]; other site 588858011329 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 588858011330 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 588858011331 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 588858011332 hypothetical protein; Provisional; Region: PRK10356 588858011333 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 588858011334 alpha-amylase; Reviewed; Region: malS; PRK09505 588858011335 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 588858011336 active site 588858011337 catalytic site [active] 588858011338 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 588858011339 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 588858011340 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858011341 homodimer interface [polypeptide binding]; other site 588858011342 catalytic residue [active] 588858011343 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 588858011344 Transcriptional regulator [Transcription]; Region: IclR; COG1414 588858011345 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 588858011346 Bacterial transcriptional regulator; Region: IclR; pfam01614 588858011347 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 588858011348 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 588858011349 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 588858011350 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 588858011351 DctM-like transporters; Region: DctM; pfam06808 588858011352 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 588858011353 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 588858011354 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 588858011355 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 588858011356 putative N- and C-terminal domain interface [polypeptide binding]; other site 588858011357 putative active site [active] 588858011358 MgATP binding site [chemical binding]; other site 588858011359 catalytic site [active] 588858011360 metal binding site [ion binding]; metal-binding site 588858011361 putative xylulose binding site [chemical binding]; other site 588858011362 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 588858011363 active site 588858011364 dimer interface [polypeptide binding]; other site 588858011365 magnesium binding site [ion binding]; other site 588858011366 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 588858011367 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 588858011368 AP (apurinic/apyrimidinic) site pocket; other site 588858011369 DNA interaction; other site 588858011370 Metal-binding active site; metal-binding site 588858011371 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 588858011372 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 588858011373 intersubunit interface [polypeptide binding]; other site 588858011374 active site 588858011375 Zn2+ binding site [ion binding]; other site 588858011376 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 588858011377 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 588858011378 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 588858011379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 588858011380 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 588858011381 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 588858011382 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 588858011383 NAD(P) binding site [chemical binding]; other site 588858011384 catalytic residues [active] 588858011385 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 588858011386 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 588858011387 nucleotide binding site [chemical binding]; other site 588858011388 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 588858011389 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 588858011390 G1 box; other site 588858011391 putative GEF interaction site [polypeptide binding]; other site 588858011392 GTP/Mg2+ binding site [chemical binding]; other site 588858011393 Switch I region; other site 588858011394 G2 box; other site 588858011395 G3 box; other site 588858011396 Switch II region; other site 588858011397 G4 box; other site 588858011398 G5 box; other site 588858011399 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 588858011400 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 588858011401 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 588858011402 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 588858011403 selenocysteine synthase; Provisional; Region: PRK04311 588858011404 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 588858011405 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 588858011406 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 588858011407 catalytic residue [active] 588858011408 putative glutathione S-transferase; Provisional; Region: PRK10357 588858011409 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 588858011410 putative C-terminal domain interface [polypeptide binding]; other site 588858011411 putative GSH binding site (G-site) [chemical binding]; other site 588858011412 putative dimer interface [polypeptide binding]; other site 588858011413 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 588858011414 dimer interface [polypeptide binding]; other site 588858011415 N-terminal domain interface [polypeptide binding]; other site 588858011416 putative substrate binding pocket (H-site) [chemical binding]; other site 588858011417 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 588858011418 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 588858011419 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 588858011420 active site 588858011421 P-loop; other site 588858011422 phosphorylation site [posttranslational modification] 588858011423 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 588858011424 active site 588858011425 phosphorylation site [posttranslational modification] 588858011426 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 588858011427 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 588858011428 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 588858011429 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 588858011430 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 588858011431 hypothetical protein; Provisional; Region: PRK11020 588858011432 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 588858011433 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 588858011434 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 588858011435 trimer interface [polypeptide binding]; other site 588858011436 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 588858011437 Haemagglutinin; Region: HIM; pfam05662 588858011438 Haemagglutinin; Region: HIM; pfam05662 588858011439 YadA-like C-terminal region; Region: YadA; pfam03895 588858011440 L-lactate permease; Provisional; Region: PRK10420 588858011441 glycolate transporter; Provisional; Region: PRK09695 588858011442 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 588858011443 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 588858011444 DNA-binding site [nucleotide binding]; DNA binding site 588858011445 FCD domain; Region: FCD; pfam07729 588858011446 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 588858011447 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 588858011448 active site 588858011449 substrate binding site [chemical binding]; other site 588858011450 FMN binding site [chemical binding]; other site 588858011451 putative catalytic residues [active] 588858011452 putative rRNA methylase; Provisional; Region: PRK10358 588858011453 Transcriptional regulators [Transcription]; Region: PurR; COG1609 588858011454 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 588858011455 DNA binding site [nucleotide binding] 588858011456 domain linker motif; other site 588858011457 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 588858011458 putative dimerization interface [polypeptide binding]; other site 588858011459 putative ligand binding site [chemical binding]; other site 588858011460 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 588858011461 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 588858011462 active site pocket [active] 588858011463 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858011464 D-galactonate transporter; Region: 2A0114; TIGR00893 588858011465 putative substrate translocation pore; other site 588858011466 serine acetyltransferase; Provisional; Region: cysE; PRK11132 588858011467 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 588858011468 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 588858011469 trimer interface [polypeptide binding]; other site 588858011470 active site 588858011471 substrate binding site [chemical binding]; other site 588858011472 CoA binding site [chemical binding]; other site 588858011473 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 588858011474 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 588858011475 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 588858011476 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 588858011477 SecA binding site; other site 588858011478 Preprotein binding site; other site 588858011479 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 588858011480 GSH binding site [chemical binding]; other site 588858011481 catalytic residues [active] 588858011482 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 588858011483 active site residue [active] 588858011484 phosphoglyceromutase; Provisional; Region: PRK05434 588858011485 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 588858011486 AmiB activator; Provisional; Region: PRK11637 588858011487 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 588858011488 Peptidase family M23; Region: Peptidase_M23; pfam01551 588858011489 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 588858011490 NodB motif; other site 588858011491 putative active site [active] 588858011492 putative catalytic site [active] 588858011493 Zn binding site [ion binding]; other site 588858011494 putative glycosyl transferase; Provisional; Region: PRK10073 588858011495 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 588858011496 active site 588858011497 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 588858011498 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 588858011499 NAD(P) binding site [chemical binding]; other site 588858011500 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 588858011501 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 588858011502 substrate-cofactor binding pocket; other site 588858011503 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858011504 catalytic residue [active] 588858011505 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 588858011506 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 588858011507 NADP binding site [chemical binding]; other site 588858011508 homopentamer interface [polypeptide binding]; other site 588858011509 substrate binding site [chemical binding]; other site 588858011510 active site 588858011511 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 588858011512 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 588858011513 putative active site [active] 588858011514 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 588858011515 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 588858011516 putative active site [active] 588858011517 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 588858011518 O-antigen ligase RfaL; Provisional; Region: PRK15487 588858011519 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 588858011520 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 588858011521 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 588858011522 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176 588858011523 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 588858011524 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 588858011525 Ligand binding site; other site 588858011526 metal-binding site 588858011527 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 588858011528 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 588858011529 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 588858011530 Ligand binding site; other site 588858011531 metal-binding site 588858011532 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 588858011533 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 588858011534 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 588858011535 putative ADP-binding pocket [chemical binding]; other site 588858011536 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 588858011537 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 588858011538 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 588858011539 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 588858011540 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 588858011541 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 588858011542 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 588858011543 putative active site [active] 588858011544 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 588858011545 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 588858011546 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 588858011547 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 588858011548 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 588858011549 active site 588858011550 (T/H)XGH motif; other site 588858011551 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 588858011552 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 588858011553 DNA binding site [nucleotide binding] 588858011554 catalytic residue [active] 588858011555 H2TH interface [polypeptide binding]; other site 588858011556 putative catalytic residues [active] 588858011557 turnover-facilitating residue; other site 588858011558 intercalation triad [nucleotide binding]; other site 588858011559 8OG recognition residue [nucleotide binding]; other site 588858011560 putative reading head residues; other site 588858011561 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 588858011562 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 588858011563 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 588858011564 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 588858011565 hypothetical protein; Reviewed; Region: PRK00024 588858011566 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 588858011567 MPN+ (JAMM) motif; other site 588858011568 Zinc-binding site [ion binding]; other site 588858011569 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 588858011570 Flavoprotein; Region: Flavoprotein; pfam02441 588858011571 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 588858011572 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 588858011573 trimer interface [polypeptide binding]; other site 588858011574 active site 588858011575 division inhibitor protein; Provisional; Region: slmA; PRK09480 588858011576 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 588858011577 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 588858011578 active site 588858011579 ribonuclease PH; Reviewed; Region: rph; PRK00173 588858011580 Ribonuclease PH; Region: RNase_PH_bact; cd11362 588858011581 hexamer interface [polypeptide binding]; other site 588858011582 active site 588858011583 hypothetical protein; Provisional; Region: PRK11820 588858011584 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 588858011585 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 588858011586 Transcriptional regulator [Transcription]; Region: LysR; COG0583 588858011587 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858011588 dimerization interface [polypeptide binding]; other site 588858011589 LysR substrate binding domain; Region: LysR_substrate; pfam03466 588858011590 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 588858011591 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 588858011592 active site 588858011593 Predicted membrane protein [Function unknown]; Region: COG2860 588858011594 UPF0126 domain; Region: UPF0126; pfam03458 588858011595 UPF0126 domain; Region: UPF0126; pfam03458 588858011596 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 588858011597 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 588858011598 nucleotide binding pocket [chemical binding]; other site 588858011599 K-X-D-G motif; other site 588858011600 catalytic site [active] 588858011601 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 588858011602 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 588858011603 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 588858011604 catalytic site [active] 588858011605 G-X2-G-X-G-K; other site 588858011606 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 588858011607 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 588858011608 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 588858011609 Zn2+ binding site [ion binding]; other site 588858011610 Mg2+ binding site [ion binding]; other site 588858011611 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 588858011612 synthetase active site [active] 588858011613 NTP binding site [chemical binding]; other site 588858011614 metal binding site [ion binding]; metal-binding site 588858011615 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 588858011616 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 588858011617 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 588858011618 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 588858011619 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 588858011620 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 588858011621 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 588858011622 generic binding surface II; other site 588858011623 ssDNA binding site; other site 588858011624 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 588858011625 ATP binding site [chemical binding]; other site 588858011626 putative Mg++ binding site [ion binding]; other site 588858011627 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 588858011628 nucleotide binding region [chemical binding]; other site 588858011629 ATP-binding site [chemical binding]; other site 588858011630 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 588858011631 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 588858011632 AsmA family; Region: AsmA; pfam05170 588858011633 putative alpha-glucosidase; Provisional; Region: PRK10658 588858011634 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 588858011635 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 588858011636 active site 588858011637 homotrimer interface [polypeptide binding]; other site 588858011638 catalytic site [active] 588858011639 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 588858011640 putative transporter; Provisional; Region: PRK11462 588858011641 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 588858011642 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 588858011643 AAA domain; Region: AAA_23; pfam13476 588858011644 Walker A/P-loop; other site 588858011645 ATP binding site [chemical binding]; other site 588858011646 AAA domain; Region: AAA_21; pfam13304 588858011647 Methyltransferase domain; Region: Methyltransf_27; pfam13708 588858011648 Virulence protein [General function prediction only]; Region: COG3943 588858011649 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 588858011650 autotransport protein MisL; Provisional; Region: PRK15313 588858011651 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 588858011652 Autotransporter beta-domain; Region: Autotransporter; pfam03797 588858011653 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 588858011654 DNA binding site [nucleotide binding] 588858011655 Isochorismatase family; Region: Isochorismatase; pfam00857 588858011656 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 588858011657 catalytic triad [active] 588858011658 dimer interface [polypeptide binding]; other site 588858011659 conserved cis-peptide bond; other site 588858011660 magnesium-transporting ATPase; Provisional; Region: PRK15122 588858011661 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 588858011662 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 588858011663 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 588858011664 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 588858011665 motif II; other site 588858011666 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 588858011667 magnesium transport protein MgtC; Provisional; Region: PRK15385 588858011668 MgtC family; Region: MgtC; pfam02308 588858011669 EamA-like transporter family; Region: EamA; pfam00892 588858011670 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 588858011671 EamA-like transporter family; Region: EamA; pfam00892 588858011672 hypothetical protein; Provisional; Region: PRK09956 588858011673 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 588858011674 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 588858011675 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 588858011676 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 588858011677 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 588858011678 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 588858011679 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 588858011680 active site 588858011681 phosphorylation site [posttranslational modification] 588858011682 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 588858011683 active pocket/dimerization site; other site 588858011684 active site 588858011685 phosphorylation site [posttranslational modification] 588858011686 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 588858011687 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 588858011688 Walker A motif; other site 588858011689 ATP binding site [chemical binding]; other site 588858011690 Walker B motif; other site 588858011691 arginine finger; other site 588858011692 Transcriptional antiterminator [Transcription]; Region: COG3933 588858011693 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 588858011694 active site 588858011695 active pocket/dimerization site; other site 588858011696 phosphorylation site [posttranslational modification] 588858011697 PRD domain; Region: PRD; pfam00874 588858011698 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 588858011699 beta-galactosidase; Region: BGL; TIGR03356 588858011700 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 588858011701 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858011702 putative substrate translocation pore; other site 588858011703 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737 588858011704 Predicted transcriptional regulator [Transcription]; Region: COG2944 588858011705 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 588858011706 non-specific DNA binding site [nucleotide binding]; other site 588858011707 salt bridge; other site 588858011708 sequence-specific DNA binding site [nucleotide binding]; other site 588858011709 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 588858011710 dimerization domain swap beta strand [polypeptide binding]; other site 588858011711 regulatory protein interface [polypeptide binding]; other site 588858011712 active site 588858011713 regulatory phosphorylation site [posttranslational modification]; other site 588858011714 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 588858011715 intersubunit interface [polypeptide binding]; other site 588858011716 active site 588858011717 zinc binding site [ion binding]; other site 588858011718 Na+ binding site [ion binding]; other site 588858011719 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 588858011720 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 588858011721 putative N- and C-terminal domain interface [polypeptide binding]; other site 588858011722 putative active site [active] 588858011723 putative MgATP binding site [chemical binding]; other site 588858011724 catalytic site [active] 588858011725 metal binding site [ion binding]; metal-binding site 588858011726 putative carbohydrate binding site [chemical binding]; other site 588858011727 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 588858011728 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 588858011729 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 588858011730 active site 588858011731 P-loop; other site 588858011732 phosphorylation site [posttranslational modification] 588858011733 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 588858011734 active site 588858011735 phosphorylation site [posttranslational modification] 588858011736 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 588858011737 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 588858011738 DNA-binding site [nucleotide binding]; DNA binding site 588858011739 UTRA domain; Region: UTRA; pfam07702 588858011740 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 588858011741 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 588858011742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858011743 putative substrate translocation pore; other site 588858011744 regulatory protein UhpC; Provisional; Region: PRK11663 588858011745 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858011746 putative substrate translocation pore; other site 588858011747 sensory histidine kinase UhpB; Provisional; Region: PRK11644 588858011748 MASE1; Region: MASE1; pfam05231 588858011749 Histidine kinase; Region: HisKA_3; pfam07730 588858011750 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 588858011751 ATP binding site [chemical binding]; other site 588858011752 Mg2+ binding site [ion binding]; other site 588858011753 G-X-G motif; other site 588858011754 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 588858011755 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 588858011756 active site 588858011757 phosphorylation site [posttranslational modification] 588858011758 intermolecular recognition site; other site 588858011759 dimerization interface [polypeptide binding]; other site 588858011760 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 588858011761 DNA binding residues [nucleotide binding] 588858011762 dimerization interface [polypeptide binding]; other site 588858011763 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 588858011764 active site 588858011765 catalytic residues [active] 588858011766 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 588858011767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858011768 putative substrate translocation pore; other site 588858011769 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 588858011770 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 588858011771 substrate binding site [chemical binding]; other site 588858011772 dimer interface [polypeptide binding]; other site 588858011773 ATP binding site [chemical binding]; other site 588858011774 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 588858011775 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 588858011776 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 588858011777 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 588858011778 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 588858011779 putative valine binding site [chemical binding]; other site 588858011780 dimer interface [polypeptide binding]; other site 588858011781 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 588858011782 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 588858011783 PYR/PP interface [polypeptide binding]; other site 588858011784 dimer interface [polypeptide binding]; other site 588858011785 TPP binding site [chemical binding]; other site 588858011786 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 588858011787 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 588858011788 TPP-binding site [chemical binding]; other site 588858011789 dimer interface [polypeptide binding]; other site 588858011790 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 588858011791 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 588858011792 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 588858011793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858011794 putative substrate translocation pore; other site 588858011795 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 588858011796 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 588858011797 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858011798 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 588858011799 dimerization interface [polypeptide binding]; other site 588858011800 substrate binding pocket [chemical binding]; other site 588858011801 permease DsdX; Provisional; Region: PRK09921 588858011802 gluconate transporter; Region: gntP; TIGR00791 588858011803 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 588858011804 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 588858011805 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 588858011806 catalytic residue [active] 588858011807 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 588858011808 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 588858011809 Domain of unknown function (DUF202); Region: DUF202; pfam02656 588858011810 Predicted membrane protein [Function unknown]; Region: COG2149 588858011811 pseudogene; frameshift 588858011812 putative transporter; Validated; Region: PRK03818 588858011813 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 588858011814 TrkA-C domain; Region: TrkA_C; pfam02080 588858011815 TrkA-C domain; Region: TrkA_C; pfam02080 588858011816 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 588858011817 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 588858011818 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 588858011819 putative dimer interface [polypeptide binding]; other site 588858011820 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 588858011821 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 588858011822 putative dimer interface [polypeptide binding]; other site 588858011823 hypothetical protein; Provisional; Region: PRK11616 588858011824 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 588858011825 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 588858011826 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 588858011827 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 588858011828 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 588858011829 catalytic residues [active] 588858011830 central insert; other site 588858011831 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 588858011832 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150 588858011833 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 588858011834 heme exporter protein CcmC; Region: ccmC; TIGR01191 588858011835 heme exporter protein CcmB; Region: ccmB; TIGR01190 588858011836 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 588858011837 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 588858011838 Walker A/P-loop; other site 588858011839 ATP binding site [chemical binding]; other site 588858011840 Q-loop/lid; other site 588858011841 ABC transporter signature motif; other site 588858011842 Walker B; other site 588858011843 D-loop; other site 588858011844 H-loop/switch region; other site 588858011845 Haem-binding domain; Region: Haem_bd; pfam14376 588858011846 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 588858011847 chaperone protein TorD; Validated; Region: torD; PRK04976 588858011848 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 588858011849 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 588858011850 molybdopterin cofactor binding site [chemical binding]; other site 588858011851 substrate binding site [chemical binding]; other site 588858011852 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 588858011853 molybdopterin cofactor binding site; other site 588858011854 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 588858011855 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 588858011856 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 588858011857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 588858011858 active site 588858011859 phosphorylation site [posttranslational modification] 588858011860 intermolecular recognition site; other site 588858011861 dimerization interface [polypeptide binding]; other site 588858011862 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 588858011863 DNA binding site [nucleotide binding] 588858011864 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 588858011865 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 588858011866 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 588858011867 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 588858011868 dimer interface [polypeptide binding]; other site 588858011869 phosphorylation site [posttranslational modification] 588858011870 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 588858011871 ATP binding site [chemical binding]; other site 588858011872 Mg2+ binding site [ion binding]; other site 588858011873 G-X-G motif; other site 588858011874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 588858011875 active site 588858011876 phosphorylation site [posttranslational modification] 588858011877 intermolecular recognition site; other site 588858011878 dimerization interface [polypeptide binding]; other site 588858011879 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 588858011880 putative binding surface; other site 588858011881 active site 588858011882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858011883 D-galactonate transporter; Region: 2A0114; TIGR00893 588858011884 putative substrate translocation pore; other site 588858011885 galactonate dehydratase; Provisional; Region: PRK14017 588858011886 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 588858011887 putative active site pocket [active] 588858011888 putative metal binding site [ion binding]; other site 588858011889 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 588858011890 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 588858011891 Transcriptional regulators [Transcription]; Region: FadR; COG2186 588858011892 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 588858011893 DNA-binding site [nucleotide binding]; DNA binding site 588858011894 FCD domain; Region: FCD; pfam07729 588858011895 sugar phosphate phosphatase; Provisional; Region: PRK10513 588858011896 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 588858011897 active site 588858011898 motif I; other site 588858011899 motif II; other site 588858011900 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 588858011901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858011902 D-galactonate transporter; Region: 2A0114; TIGR00893 588858011903 putative substrate translocation pore; other site 588858011904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858011905 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 588858011906 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 588858011907 active site pocket [active] 588858011908 Transcriptional regulator [Transcription]; Region: LysR; COG0583 588858011909 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858011910 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 588858011911 putative dimerization interface [polypeptide binding]; other site 588858011912 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 588858011913 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 588858011914 Mg2+ binding site [ion binding]; other site 588858011915 G-X-G motif; other site 588858011916 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 588858011917 anchoring element; other site 588858011918 dimer interface [polypeptide binding]; other site 588858011919 ATP binding site [chemical binding]; other site 588858011920 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 588858011921 active site 588858011922 putative metal-binding site [ion binding]; other site 588858011923 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 588858011924 recF protein; Region: recf; TIGR00611 588858011925 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 588858011926 Walker A/P-loop; other site 588858011927 ATP binding site [chemical binding]; other site 588858011928 Q-loop/lid; other site 588858011929 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 588858011930 ABC transporter signature motif; other site 588858011931 Walker B; other site 588858011932 D-loop; other site 588858011933 H-loop/switch region; other site 588858011934 DNA polymerase III subunit beta; Validated; Region: PRK05643 588858011935 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 588858011936 putative DNA binding surface [nucleotide binding]; other site 588858011937 dimer interface [polypeptide binding]; other site 588858011938 beta-clamp/clamp loader binding surface; other site 588858011939 beta-clamp/translesion DNA polymerase binding surface; other site 588858011940 DnaA N-terminal domain; Region: DnaA_N; pfam11638 588858011941 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 588858011942 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 588858011943 Walker A motif; other site 588858011944 ATP binding site [chemical binding]; other site 588858011945 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 588858011946 Walker B motif; other site 588858011947 arginine finger; other site 588858011948 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 588858011949 DnaA box-binding interface [nucleotide binding]; other site 588858011950 ent-kaur-16-ene synthase; Region: PLN02279 588858011951 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 588858011952 ribonuclease P; Reviewed; Region: rnpA; PRK01732 588858011953 hypothetical protein; Validated; Region: PRK00041 588858011954 membrane protein insertase; Provisional; Region: PRK01318 588858011955 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 588858011956 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 588858011957 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 588858011958 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 588858011959 trmE is a tRNA modification GTPase; Region: trmE; cd04164 588858011960 G1 box; other site 588858011961 GTP/Mg2+ binding site [chemical binding]; other site 588858011962 Switch I region; other site 588858011963 G2 box; other site 588858011964 Switch II region; other site 588858011965 G3 box; other site 588858011966 G4 box; other site 588858011967 G5 box; other site 588858011968 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 588858011969 pseudogene; in-frame stop; putative integrase 588858011970 putative transferase, LIC12162 family; Region: o_ant_LIC12162; TIGR04331 588858011971 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 588858011972 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 588858011973 putative active site [active] 588858011974 putative NTP binding site [chemical binding]; other site 588858011975 putative nucleic acid binding site [nucleotide binding]; other site 588858011976 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 588858011977 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858011978 putative substrate translocation pore; other site 588858011979 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 588858011980 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858011981 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 588858011982 substrate binding pocket [chemical binding]; other site 588858011983 dimerization interface [polypeptide binding]; other site 588858011984 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 588858011985 Predicted flavoprotein [General function prediction only]; Region: COG0431 588858011986 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 588858011987 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 588858011988 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 588858011989 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 588858011990 active site 588858011991 motif I; other site 588858011992 motif II; other site 588858011993 transcriptional regulator PhoU; Provisional; Region: PRK11115 588858011994 PhoU domain; Region: PhoU; pfam01895 588858011995 PhoU domain; Region: PhoU; pfam01895 588858011996 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 588858011997 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 588858011998 Walker A/P-loop; other site 588858011999 ATP binding site [chemical binding]; other site 588858012000 Q-loop/lid; other site 588858012001 ABC transporter signature motif; other site 588858012002 Walker B; other site 588858012003 D-loop; other site 588858012004 H-loop/switch region; other site 588858012005 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 588858012006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858012007 dimer interface [polypeptide binding]; other site 588858012008 conserved gate region; other site 588858012009 putative PBP binding loops; other site 588858012010 ABC-ATPase subunit interface; other site 588858012011 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 588858012012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858012013 dimer interface [polypeptide binding]; other site 588858012014 conserved gate region; other site 588858012015 putative PBP binding loops; other site 588858012016 ABC-ATPase subunit interface; other site 588858012017 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 588858012018 substrate binding pocket [chemical binding]; other site 588858012019 membrane-bound complex binding site; other site 588858012020 hinge residues; other site 588858012021 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 588858012022 active site 588858012023 P-loop; other site 588858012024 phosphorylation site [posttranslational modification] 588858012025 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 588858012026 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 588858012027 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 588858012028 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 588858012029 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 588858012030 shikimate binding site; other site 588858012031 NAD(P) binding site [chemical binding]; other site 588858012032 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 588858012033 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 588858012034 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 588858012035 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 588858012036 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 588858012037 glutaminase active site [active] 588858012038 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 588858012039 dimer interface [polypeptide binding]; other site 588858012040 active site 588858012041 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 588858012042 dimer interface [polypeptide binding]; other site 588858012043 active site 588858012044 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 588858012045 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 588858012046 Substrate binding site; other site 588858012047 Mg++ binding site; other site 588858012048 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 588858012049 active site 588858012050 substrate binding site [chemical binding]; other site 588858012051 CoA binding site [chemical binding]; other site 588858012052 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 588858012053 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 588858012054 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 588858012055 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 588858012056 gamma subunit interface [polypeptide binding]; other site 588858012057 epsilon subunit interface [polypeptide binding]; other site 588858012058 LBP interface [polypeptide binding]; other site 588858012059 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 588858012060 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 588858012061 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 588858012062 alpha subunit interaction interface [polypeptide binding]; other site 588858012063 Walker A motif; other site 588858012064 ATP binding site [chemical binding]; other site 588858012065 Walker B motif; other site 588858012066 inhibitor binding site; inhibition site 588858012067 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 588858012068 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 588858012069 core domain interface [polypeptide binding]; other site 588858012070 delta subunit interface [polypeptide binding]; other site 588858012071 epsilon subunit interface [polypeptide binding]; other site 588858012072 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 588858012073 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 588858012074 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 588858012075 beta subunit interaction interface [polypeptide binding]; other site 588858012076 Walker A motif; other site 588858012077 ATP binding site [chemical binding]; other site 588858012078 Walker B motif; other site 588858012079 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 588858012080 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 588858012081 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 588858012082 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 588858012083 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 588858012084 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 588858012085 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 588858012086 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 588858012087 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 588858012088 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 588858012089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 588858012090 S-adenosylmethionine binding site [chemical binding]; other site 588858012091 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 588858012092 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 588858012093 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 588858012094 FMN-binding protein MioC; Provisional; Region: PRK09004 588858012095 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 588858012096 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 588858012097 putative DNA binding site [nucleotide binding]; other site 588858012098 putative Zn2+ binding site [ion binding]; other site 588858012099 AsnC family; Region: AsnC_trans_reg; pfam01037 588858012100 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 588858012101 dimer interface [polypeptide binding]; other site 588858012102 active site 588858012103 hypothetical protein; Provisional; Region: yieM; PRK10997 588858012104 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 588858012105 metal ion-dependent adhesion site (MIDAS); other site 588858012106 regulatory ATPase RavA; Provisional; Region: PRK13531 588858012107 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 588858012108 Walker A motif; other site 588858012109 ATP binding site [chemical binding]; other site 588858012110 Walker B motif; other site 588858012111 arginine finger; other site 588858012112 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 588858012113 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 588858012114 potassium uptake protein; Region: kup; TIGR00794 588858012115 D-ribose pyranase; Provisional; Region: PRK11797 588858012116 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 588858012117 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 588858012118 Walker A/P-loop; other site 588858012119 ATP binding site [chemical binding]; other site 588858012120 Q-loop/lid; other site 588858012121 ABC transporter signature motif; other site 588858012122 Walker B; other site 588858012123 D-loop; other site 588858012124 H-loop/switch region; other site 588858012125 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 588858012126 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 588858012127 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 588858012128 TM-ABC transporter signature motif; other site 588858012129 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 588858012130 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 588858012131 ligand binding site [chemical binding]; other site 588858012132 dimerization interface [polypeptide binding]; other site 588858012133 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 588858012134 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 588858012135 substrate binding site [chemical binding]; other site 588858012136 dimer interface [polypeptide binding]; other site 588858012137 ATP binding site [chemical binding]; other site 588858012138 transcriptional repressor RbsR; Provisional; Region: PRK10423 588858012139 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 588858012140 DNA binding site [nucleotide binding] 588858012141 domain linker motif; other site 588858012142 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 588858012143 dimerization interface [polypeptide binding]; other site 588858012144 ligand binding site [chemical binding]; other site 588858012145 putative transporter; Provisional; Region: PRK10504 588858012146 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858012147 putative substrate translocation pore; other site 588858012148 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858012149 Transcriptional regulators [Transcription]; Region: FadR; COG2186 588858012150 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 588858012151 DNA-binding site [nucleotide binding]; DNA binding site 588858012152 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 588858012153 transcriptional regulator HdfR; Provisional; Region: PRK03601 588858012154 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858012155 LysR substrate binding domain; Region: LysR_substrate; pfam03466 588858012156 dimerization interface [polypeptide binding]; other site 588858012157 hypothetical protein; Provisional; Region: PRK11027 588858012158 putative ATP-dependent protease; Provisional; Region: PRK09862 588858012159 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 588858012160 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 588858012161 Walker A motif; other site 588858012162 ATP binding site [chemical binding]; other site 588858012163 Walker B motif; other site 588858012164 arginine finger; other site 588858012165 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 588858012166 ilvG operon leader peptide; Provisional; Region: PRK10424 588858012167 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 588858012168 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 588858012169 PYR/PP interface [polypeptide binding]; other site 588858012170 dimer interface [polypeptide binding]; other site 588858012171 TPP binding site [chemical binding]; other site 588858012172 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 588858012173 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 588858012174 TPP-binding site [chemical binding]; other site 588858012175 dimer interface [polypeptide binding]; other site 588858012176 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 588858012177 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 588858012178 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 588858012179 homodimer interface [polypeptide binding]; other site 588858012180 substrate-cofactor binding pocket; other site 588858012181 catalytic residue [active] 588858012182 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 588858012183 threonine dehydratase; Reviewed; Region: PRK09224 588858012184 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 588858012185 tetramer interface [polypeptide binding]; other site 588858012186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858012187 catalytic residue [active] 588858012188 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 588858012189 putative Ile/Val binding site [chemical binding]; other site 588858012190 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 588858012191 putative Ile/Val binding site [chemical binding]; other site 588858012192 Phage-related protein [Function unknown]; Region: COG4679 588858012193 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 588858012194 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858012195 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 588858012196 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 588858012197 putative dimerization interface [polypeptide binding]; other site 588858012198 ketol-acid reductoisomerase; Validated; Region: PRK05225 588858012199 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 588858012200 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 588858012201 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 588858012202 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 588858012203 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 588858012204 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 588858012205 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 588858012206 Part of AAA domain; Region: AAA_19; pfam13245 588858012207 Family description; Region: UvrD_C_2; pfam13538 588858012208 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 588858012209 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 588858012210 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 588858012211 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 588858012212 ATP binding site [chemical binding]; other site 588858012213 Mg++ binding site [ion binding]; other site 588858012214 motif III; other site 588858012215 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 588858012216 nucleotide binding region [chemical binding]; other site 588858012217 ATP-binding site [chemical binding]; other site 588858012218 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 588858012219 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 588858012220 catalytic residues [active] 588858012221 pseudogene; no in-frame start 588858012222 transcription termination factor Rho; Provisional; Region: rho; PRK09376 588858012223 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 588858012224 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 588858012225 RNA binding site [nucleotide binding]; other site 588858012226 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 588858012227 multimer interface [polypeptide binding]; other site 588858012228 Walker A motif; other site 588858012229 ATP binding site [chemical binding]; other site 588858012230 Walker B motif; other site 588858012231 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 588858012232 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 588858012233 Mg++ binding site [ion binding]; other site 588858012234 putative catalytic motif [active] 588858012235 substrate binding site [chemical binding]; other site 588858012236 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 588858012237 Chain length determinant protein; Region: Wzz; pfam02706 588858012238 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 588858012239 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 588858012240 active site 588858012241 homodimer interface [polypeptide binding]; other site 588858012242 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 588858012243 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 588858012244 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 588858012245 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 588858012246 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 588858012247 NAD binding site [chemical binding]; other site 588858012248 substrate binding site [chemical binding]; other site 588858012249 homodimer interface [polypeptide binding]; other site 588858012250 active site 588858012251 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 588858012252 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 588858012253 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 588858012254 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 588858012255 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 588858012256 inhibitor-cofactor binding pocket; inhibition site 588858012257 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858012258 catalytic residue [active] 588858012259 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 588858012260 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 588858012261 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 588858012262 putative common antigen polymerase; Provisional; Region: PRK02975 588858012263 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 588858012264 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 588858012265 putative transport protein YifK; Provisional; Region: PRK10746 588858012266 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 588858012267 HemY protein N-terminus; Region: HemY_N; pfam07219 588858012268 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 588858012269 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 588858012270 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 588858012271 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 588858012272 active site 588858012273 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 588858012274 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 588858012275 domain interfaces; other site 588858012276 active site 588858012277 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 588858012278 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 588858012279 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 588858012280 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 588858012281 putative iron binding site [ion binding]; other site 588858012282 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 588858012283 pseudogene; 2 frameshifts 588858012284 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 588858012285 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 588858012286 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 588858012287 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 588858012288 hypothetical protein; Provisional; Region: PRK10963 588858012289 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 588858012290 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 588858012291 active site 588858012292 Int/Topo IB signature motif; other site 588858012293 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 588858012294 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 588858012295 motif II; other site 588858012296 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 588858012297 Part of AAA domain; Region: AAA_19; pfam13245 588858012298 Family description; Region: UvrD_C_2; pfam13538 588858012299 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 588858012300 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 588858012301 Cl binding site [ion binding]; other site 588858012302 oligomer interface [polypeptide binding]; other site 588858012303 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 588858012304 hypothetical protein; Provisional; Region: PRK11371 588858012305 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 588858012306 EamA-like transporter family; Region: EamA; cl17759 588858012307 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 588858012308 CoenzymeA binding site [chemical binding]; other site 588858012309 subunit interaction site [polypeptide binding]; other site 588858012310 PHB binding site; other site 588858012311 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 588858012312 dimerization interface [polypeptide binding]; other site 588858012313 substrate binding site [chemical binding]; other site 588858012314 active site 588858012315 calcium binding site [ion binding]; other site 588858012316 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 588858012317 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 588858012318 ATP binding site [chemical binding]; other site 588858012319 putative Mg++ binding site [ion binding]; other site 588858012320 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 588858012321 nucleotide binding region [chemical binding]; other site 588858012322 ATP-binding site [chemical binding]; other site 588858012323 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 588858012324 Helicase and RNase D C-terminal; Region: HRDC; smart00341 588858012325 threonine efflux system; Provisional; Region: PRK10229 588858012326 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 588858012327 lysophospholipase L2; Provisional; Region: PRK10749 588858012328 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 588858012329 putative hydrolase; Provisional; Region: PRK10976 588858012330 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 588858012331 active site 588858012332 motif I; other site 588858012333 motif II; other site 588858012334 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 588858012335 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 588858012336 EamA-like transporter family; Region: EamA; pfam00892 588858012337 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 588858012338 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858012339 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 588858012340 putative dimerization interface [polypeptide binding]; other site 588858012341 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 588858012342 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 588858012343 THF binding site; other site 588858012344 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 588858012345 substrate binding site [chemical binding]; other site 588858012346 THF binding site; other site 588858012347 zinc-binding site [ion binding]; other site 588858012348 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 588858012349 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 588858012350 FeS/SAM binding site; other site 588858012351 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 588858012352 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 588858012353 uridine phosphorylase; Provisional; Region: PRK11178 588858012354 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 588858012355 DNA recombination protein RmuC; Provisional; Region: PRK10361 588858012356 RmuC family; Region: RmuC; pfam02646 588858012357 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 588858012358 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 588858012359 S-adenosylmethionine binding site [chemical binding]; other site 588858012360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 588858012361 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 588858012362 SCP-2 sterol transfer family; Region: SCP2; pfam02036 588858012363 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 588858012364 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 588858012365 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 588858012366 sec-independent translocase; Provisional; Region: PRK01770 588858012367 sec-independent translocase; Provisional; Region: tatB; PRK00404 588858012368 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 588858012369 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 588858012370 active site 588858012371 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 588858012372 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 588858012373 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 588858012374 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 588858012375 FMN reductase; Validated; Region: fre; PRK08051 588858012376 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 588858012377 FAD binding pocket [chemical binding]; other site 588858012378 FAD binding motif [chemical binding]; other site 588858012379 phosphate binding motif [ion binding]; other site 588858012380 beta-alpha-beta structure motif; other site 588858012381 NAD binding pocket [chemical binding]; other site 588858012382 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 588858012383 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 588858012384 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 588858012385 dimer interface [polypeptide binding]; other site 588858012386 active site 588858012387 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 588858012388 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 588858012389 substrate binding site [chemical binding]; other site 588858012390 oxyanion hole (OAH) forming residues; other site 588858012391 trimer interface [polypeptide binding]; other site 588858012392 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 588858012393 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 588858012394 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 588858012395 proline dipeptidase; Provisional; Region: PRK13607 588858012396 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 588858012397 active site 588858012398 hypothetical protein; Provisional; Region: PRK11568 588858012399 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 588858012400 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 588858012401 potassium transporter; Provisional; Region: PRK10750 588858012402 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 588858012403 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 588858012404 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 588858012405 Walker A motif; other site 588858012406 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 588858012407 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 588858012408 GTP binding site; other site 588858012409 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 588858012410 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 588858012411 serine/threonine protein kinase; Provisional; Region: PRK11768 588858012412 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 588858012413 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 588858012414 catalytic residues [active] 588858012415 hinge region; other site 588858012416 alpha helical domain; other site 588858012417 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 588858012418 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 588858012419 putative acyl-acceptor binding pocket; other site 588858012420 DNA polymerase I; Provisional; Region: PRK05755 588858012421 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 588858012422 active site 588858012423 metal binding site 1 [ion binding]; metal-binding site 588858012424 putative 5' ssDNA interaction site; other site 588858012425 metal binding site 3; metal-binding site 588858012426 metal binding site 2 [ion binding]; metal-binding site 588858012427 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 588858012428 putative DNA binding site [nucleotide binding]; other site 588858012429 putative metal binding site [ion binding]; other site 588858012430 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 588858012431 active site 588858012432 catalytic site [active] 588858012433 substrate binding site [chemical binding]; other site 588858012434 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 588858012435 active site 588858012436 DNA binding site [nucleotide binding] 588858012437 catalytic site [active] 588858012438 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 588858012439 G1 box; other site 588858012440 GTP/Mg2+ binding site [chemical binding]; other site 588858012441 Switch I region; other site 588858012442 G2 box; other site 588858012443 G3 box; other site 588858012444 Switch II region; other site 588858012445 G4 box; other site 588858012446 G5 box; other site 588858012447 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 588858012448 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 588858012449 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 588858012450 FeS/SAM binding site; other site 588858012451 HemN C-terminal domain; Region: HemN_C; pfam06969 588858012452 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 588858012453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 588858012454 active site 588858012455 phosphorylation site [posttranslational modification] 588858012456 intermolecular recognition site; other site 588858012457 dimerization interface [polypeptide binding]; other site 588858012458 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 588858012459 Walker A motif; other site 588858012460 ATP binding site [chemical binding]; other site 588858012461 Walker B motif; other site 588858012462 arginine finger; other site 588858012463 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 588858012464 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 588858012465 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 588858012466 putative active site [active] 588858012467 heme pocket [chemical binding]; other site 588858012468 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 588858012469 dimer interface [polypeptide binding]; other site 588858012470 phosphorylation site [posttranslational modification] 588858012471 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 588858012472 ATP binding site [chemical binding]; other site 588858012473 Mg2+ binding site [ion binding]; other site 588858012474 G-X-G motif; other site 588858012475 glutamine synthetase; Provisional; Region: glnA; PRK09469 588858012476 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 588858012477 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 588858012478 GTP-binding protein; Provisional; Region: PRK10218 588858012479 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 588858012480 G1 box; other site 588858012481 putative GEF interaction site [polypeptide binding]; other site 588858012482 GTP/Mg2+ binding site [chemical binding]; other site 588858012483 Switch I region; other site 588858012484 G2 box; other site 588858012485 G3 box; other site 588858012486 Switch II region; other site 588858012487 G4 box; other site 588858012488 G5 box; other site 588858012489 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 588858012490 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 588858012491 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 588858012492 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 588858012493 active site 588858012494 motif I; other site 588858012495 motif II; other site 588858012496 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 588858012497 coproporphyrinogen III oxidase; Validated; Region: PRK08208 588858012498 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 588858012499 FeS/SAM binding site; other site 588858012500 HemN C-terminal domain; Region: HemN_C; pfam06969 588858012501 Sulfatase; Region: Sulfatase; cl17466 588858012502 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 588858012503 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 588858012504 Leucine-rich repeats; other site 588858012505 Substrate binding site [chemical binding]; other site 588858012506 outer membrane porin L; Provisional; Region: ompL; PRK09980 588858012507 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 588858012508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858012509 putative substrate translocation pore; other site 588858012510 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 588858012511 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 588858012512 alpha-glucosidase; Provisional; Region: PRK10426 588858012513 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 588858012514 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 588858012515 putative active site [active] 588858012516 putative catalytic site [active] 588858012517 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 588858012518 active site 588858012519 catalytic residues [active] 588858012520 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 588858012521 dimerization interface [polypeptide binding]; other site 588858012522 putative active cleft [active] 588858012523 Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684 588858012524 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 588858012525 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 588858012526 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 588858012527 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 588858012528 substrate binding site [chemical binding]; other site 588858012529 ATP binding site [chemical binding]; other site 588858012530 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 588858012531 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 588858012532 putative DNA binding site [nucleotide binding]; other site 588858012533 putative Zn2+ binding site [ion binding]; other site 588858012534 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 588858012535 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 588858012536 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 588858012537 motif II; other site 588858012538 hypothetical protein; Reviewed; Region: PRK01637 588858012539 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 588858012540 putative active site [active] 588858012541 dimerization interface [polypeptide binding]; other site 588858012542 putative tRNAtyr binding site [nucleotide binding]; other site 588858012543 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 588858012544 Coenzyme A binding pocket [chemical binding]; other site 588858012545 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 588858012546 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 588858012547 non-specific DNA binding site [nucleotide binding]; other site 588858012548 salt bridge; other site 588858012549 sequence-specific DNA binding site [nucleotide binding]; other site 588858012550 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680 588858012551 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 588858012552 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 588858012553 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 588858012554 Predicted transcriptional regulator [Transcription]; Region: COG2944 588858012555 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 588858012556 non-specific DNA binding site [nucleotide binding]; other site 588858012557 salt bridge; other site 588858012558 sequence-specific DNA binding site [nucleotide binding]; other site 588858012559 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 588858012560 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 588858012561 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 588858012562 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 588858012563 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 588858012564 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 588858012565 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 588858012566 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 588858012567 [4Fe-4S] binding site [ion binding]; other site 588858012568 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 588858012569 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 588858012570 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 588858012571 molybdopterin cofactor binding site; other site 588858012572 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 588858012573 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 588858012574 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 588858012575 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 588858012576 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 588858012577 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 588858012578 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 588858012579 non-specific DNA binding site [nucleotide binding]; other site 588858012580 salt bridge; other site 588858012581 sequence-specific DNA binding site [nucleotide binding]; other site 588858012582 Cupin domain; Region: Cupin_2; cl17218 588858012583 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 588858012584 lactaldehyde reductase; Region: lactal_redase; TIGR02638 588858012585 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 588858012586 dimer interface [polypeptide binding]; other site 588858012587 active site 588858012588 metal binding site [ion binding]; metal-binding site 588858012589 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 588858012590 intersubunit interface [polypeptide binding]; other site 588858012591 active site 588858012592 Zn2+ binding site [ion binding]; other site 588858012593 L-rhamnose isomerase; Provisional; Region: PRK01076 588858012594 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 588858012595 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 588858012596 N- and C-terminal domain interface [polypeptide binding]; other site 588858012597 active site 588858012598 putative catalytic site [active] 588858012599 metal binding site [ion binding]; metal-binding site 588858012600 ATP binding site [chemical binding]; other site 588858012601 rhamnulokinase; Provisional; Region: rhaB; PRK10640 588858012602 carbohydrate binding site [chemical binding]; other site 588858012603 transcriptional activator RhaS; Provisional; Region: PRK13503 588858012604 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 588858012605 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 588858012606 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 588858012607 transcriptional activator RhaR; Provisional; Region: PRK13502 588858012608 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 588858012609 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 588858012610 L-rhamnose-proton symport protein (RhaT); Region: RhaT; pfam06379 588858012611 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 588858012612 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178 588858012613 DctM-like transporters; Region: DctM; pfam06808 588858012614 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 588858012615 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 588858012616 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 588858012617 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 588858012618 superoxide dismutase; Provisional; Region: PRK10925 588858012619 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 588858012620 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 588858012621 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 588858012622 MOSC domain; Region: MOSC; pfam03473 588858012623 3-alpha domain; Region: 3-alpha; pfam03475 588858012624 SnoaL-like domain; Region: SnoaL_2; pfam12680 588858012625 two-component sensor protein; Provisional; Region: cpxA; PRK09470 588858012626 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 588858012627 dimerization interface [polypeptide binding]; other site 588858012628 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 588858012629 dimer interface [polypeptide binding]; other site 588858012630 phosphorylation site [posttranslational modification] 588858012631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 588858012632 ATP binding site [chemical binding]; other site 588858012633 Mg2+ binding site [ion binding]; other site 588858012634 G-X-G motif; other site 588858012635 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 588858012636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 588858012637 active site 588858012638 intermolecular recognition site; other site 588858012639 dimerization interface [polypeptide binding]; other site 588858012640 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 588858012641 DNA binding site [nucleotide binding] 588858012642 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 588858012643 dimer interface [polypeptide binding]; other site 588858012644 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 588858012645 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 588858012646 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 588858012647 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 588858012648 active site 588858012649 ADP/pyrophosphate binding site [chemical binding]; other site 588858012650 dimerization interface [polypeptide binding]; other site 588858012651 allosteric effector site; other site 588858012652 fructose-1,6-bisphosphate binding site; other site 588858012653 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 588858012654 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 588858012655 substrate binding pocket [chemical binding]; other site 588858012656 membrane-bound complex binding site; other site 588858012657 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 588858012658 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 588858012659 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 588858012660 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 588858012661 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 588858012662 putative substrate binding site [chemical binding]; other site 588858012663 putative ATP binding site [chemical binding]; other site 588858012664 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 588858012665 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 588858012666 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 588858012667 DNA-binding site [nucleotide binding]; DNA binding site 588858012668 Alanine racemase, C-terminal domain; Region: Ala_racemase_C; cl08293 588858012669 UTRA domain; Region: UTRA; pfam07702 588858012670 CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934 588858012671 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 588858012672 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 588858012673 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 588858012674 putative N- and C-terminal domain interface [polypeptide binding]; other site 588858012675 putative active site [active] 588858012676 putative MgATP binding site [chemical binding]; other site 588858012677 catalytic site [active] 588858012678 metal binding site [ion binding]; metal-binding site 588858012679 putative carbohydrate binding site [chemical binding]; other site 588858012680 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 588858012681 transcriptional regulator LsrR; Provisional; Region: PRK15418 588858012682 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 588858012683 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 588858012684 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 588858012685 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 588858012686 Walker A/P-loop; other site 588858012687 ATP binding site [chemical binding]; other site 588858012688 Q-loop/lid; other site 588858012689 ABC transporter signature motif; other site 588858012690 Walker B; other site 588858012691 D-loop; other site 588858012692 H-loop/switch region; other site 588858012693 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 588858012694 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 588858012695 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 588858012696 TM-ABC transporter signature motif; other site 588858012697 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 588858012698 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 588858012699 TM-ABC transporter signature motif; other site 588858012700 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 588858012701 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 588858012702 ligand binding site [chemical binding]; other site 588858012703 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 588858012704 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 588858012705 putative active site; other site 588858012706 catalytic residue [active] 588858012707 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 588858012708 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 588858012709 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 588858012710 substrate binding site [chemical binding]; other site 588858012711 hexamer interface [polypeptide binding]; other site 588858012712 metal binding site [ion binding]; metal-binding site 588858012713 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 588858012714 triosephosphate isomerase; Provisional; Region: PRK14567 588858012715 substrate binding site [chemical binding]; other site 588858012716 dimer interface [polypeptide binding]; other site 588858012717 catalytic triad [active] 588858012718 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 588858012719 Predicted membrane protein [Function unknown]; Region: COG3152 588858012720 ferredoxin-NADP reductase; Provisional; Region: PRK10926 588858012721 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 588858012722 FAD binding pocket [chemical binding]; other site 588858012723 FAD binding motif [chemical binding]; other site 588858012724 phosphate binding motif [ion binding]; other site 588858012725 beta-alpha-beta structure motif; other site 588858012726 NAD binding pocket [chemical binding]; other site 588858012727 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 588858012728 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 588858012729 putative active site [active] 588858012730 glycerol kinase; Provisional; Region: glpK; PRK00047 588858012731 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 588858012732 N- and C-terminal domain interface [polypeptide binding]; other site 588858012733 active site 588858012734 MgATP binding site [chemical binding]; other site 588858012735 catalytic site [active] 588858012736 metal binding site [ion binding]; metal-binding site 588858012737 glycerol binding site [chemical binding]; other site 588858012738 homotetramer interface [polypeptide binding]; other site 588858012739 homodimer interface [polypeptide binding]; other site 588858012740 FBP binding site [chemical binding]; other site 588858012741 protein IIAGlc interface [polypeptide binding]; other site 588858012742 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 588858012743 amphipathic channel; other site 588858012744 Asn-Pro-Ala signature motifs; other site 588858012745 septal ring assembly protein ZapB; Provisional; Region: PRK15422 588858012746 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 588858012747 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 588858012748 UbiA prenyltransferase family; Region: UbiA; pfam01040 588858012749 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 588858012750 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 588858012751 Walker A motif; other site 588858012752 ATP binding site [chemical binding]; other site 588858012753 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 588858012754 Walker B motif; other site 588858012755 arginine finger; other site 588858012756 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 588858012757 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 588858012758 active site 588858012759 HslU subunit interaction site [polypeptide binding]; other site 588858012760 essential cell division protein FtsN; Provisional; Region: PRK10927 588858012761 cell division protein FtsN; Provisional; Region: PRK12757 588858012762 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 588858012763 DNA binding site [nucleotide binding] 588858012764 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 588858012765 domain linker motif; other site 588858012766 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 588858012767 dimerization interface [polypeptide binding]; other site 588858012768 ligand binding site [chemical binding]; other site 588858012769 primosome assembly protein PriA; Validated; Region: PRK05580 588858012770 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 588858012771 ATP binding site [chemical binding]; other site 588858012772 putative Mg++ binding site [ion binding]; other site 588858012773 helicase superfamily c-terminal domain; Region: HELICc; smart00490 588858012774 ATP-binding site [chemical binding]; other site 588858012775 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 588858012776 conserved hypothetical protein; Region: chp_urease_rgn; TIGR02117 588858012777 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 588858012778 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 588858012779 dimerization interface [polypeptide binding]; other site 588858012780 DNA binding site [nucleotide binding] 588858012781 corepressor binding sites; other site 588858012782 cystathionine gamma-synthase; Provisional; Region: PRK08045 588858012783 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 588858012784 homodimer interface [polypeptide binding]; other site 588858012785 substrate-cofactor binding pocket; other site 588858012786 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858012787 catalytic residue [active] 588858012788 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 588858012789 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 588858012790 putative catalytic residues [active] 588858012791 putative nucleotide binding site [chemical binding]; other site 588858012792 putative aspartate binding site [chemical binding]; other site 588858012793 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 588858012794 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 588858012795 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 588858012796 mechanosensitive channel MscS; Provisional; Region: PRK10334 588858012797 Conserved TM helix; Region: TM_helix; pfam05552 588858012798 Mechanosensitive ion channel; Region: MS_channel; pfam00924 588858012799 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 588858012800 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 588858012801 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 588858012802 active site 588858012803 metal binding site [ion binding]; metal-binding site 588858012804 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 588858012805 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 588858012806 FAD binding site [chemical binding]; other site 588858012807 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 588858012808 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 588858012809 heme binding site [chemical binding]; other site 588858012810 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 588858012811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 588858012812 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 588858012813 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 588858012814 dimer interface [polypeptide binding]; other site 588858012815 active site 588858012816 metal binding site [ion binding]; metal-binding site 588858012817 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 588858012818 active site 588858012819 intersubunit interactions; other site 588858012820 catalytic residue [active] 588858012821 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 588858012822 dimerization domain swap beta strand [polypeptide binding]; other site 588858012823 regulatory protein interface [polypeptide binding]; other site 588858012824 active site 588858012825 regulatory phosphorylation site [posttranslational modification]; other site 588858012826 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 588858012827 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 588858012828 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 588858012829 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 588858012830 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 588858012831 active site 588858012832 phosphorylation site [posttranslational modification] 588858012833 pseudogene; frameshift 588858012834 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 588858012835 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 588858012836 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 588858012837 active site 588858012838 P-loop; other site 588858012839 phosphorylation site [posttranslational modification] 588858012840 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 588858012841 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 588858012842 dimer interface [polypeptide binding]; other site 588858012843 active site 588858012844 glycine loop; other site 588858012845 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 588858012846 FeS/SAM binding site; other site 588858012847 pyruvate formate lyase II activase; Provisional; Region: PRK10076 588858012848 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 588858012849 active site 588858012850 P-loop; other site 588858012851 phosphorylation site [posttranslational modification] 588858012852 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 588858012853 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 588858012854 hypothetical protein; Provisional; Region: PRK10649 588858012855 Sulfatase; Region: Sulfatase; pfam00884 588858012856 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 588858012857 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 588858012858 acetylornithine deacetylase; Provisional; Region: PRK05111 588858012859 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 588858012860 metal binding site [ion binding]; metal-binding site 588858012861 putative dimer interface [polypeptide binding]; other site 588858012862 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 588858012863 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 588858012864 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 588858012865 nucleotide binding site [chemical binding]; other site 588858012866 N-acetyl-L-glutamate binding site [chemical binding]; other site 588858012867 argininosuccinate lyase; Provisional; Region: PRK04833 588858012868 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 588858012869 active sites [active] 588858012870 tetramer interface [polypeptide binding]; other site 588858012871 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 588858012872 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858012873 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 588858012874 dimerization interface [polypeptide binding]; other site 588858012875 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 588858012876 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 588858012877 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 588858012878 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 588858012879 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 588858012880 hypothetical protein; Provisional; Region: PRK11056 588858012881 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 588858012882 Protein of unknown function (DUF3164); Region: DUF3164; pfam11363 588858012883 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 588858012884 S-adenosylmethionine binding site [chemical binding]; other site 588858012885 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 588858012886 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 588858012887 N-terminal plug; other site 588858012888 ligand-binding site [chemical binding]; other site 588858012889 glutamate racemase; Provisional; Region: PRK00865 588858012890 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 588858012891 FAD binding domain; Region: FAD_binding_4; pfam01565 588858012892 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 588858012893 Biotin operon repressor [Transcription]; Region: BirA; COG1654 588858012894 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 588858012895 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 588858012896 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 588858012897 pantothenate kinase; Provisional; Region: PRK05439 588858012898 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 588858012899 ATP-binding site [chemical binding]; other site 588858012900 CoA-binding site [chemical binding]; other site 588858012901 Mg2+-binding site [ion binding]; other site 588858012902 pseudogene; no in-frame start 588858012903 elongation factor Tu; Reviewed; Region: PRK00049 588858012904 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 588858012905 G1 box; other site 588858012906 GEF interaction site [polypeptide binding]; other site 588858012907 GTP/Mg2+ binding site [chemical binding]; other site 588858012908 Switch I region; other site 588858012909 G2 box; other site 588858012910 G3 box; other site 588858012911 Switch II region; other site 588858012912 G4 box; other site 588858012913 G5 box; other site 588858012914 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 588858012915 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 588858012916 Antibiotic Binding Site [chemical binding]; other site 588858012917 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 588858012918 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 588858012919 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 588858012920 putative homodimer interface [polypeptide binding]; other site 588858012921 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 588858012922 heterodimer interface [polypeptide binding]; other site 588858012923 homodimer interface [polypeptide binding]; other site 588858012924 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 588858012925 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 588858012926 23S rRNA interface [nucleotide binding]; other site 588858012927 L7/L12 interface [polypeptide binding]; other site 588858012928 putative thiostrepton binding site; other site 588858012929 L25 interface [polypeptide binding]; other site 588858012930 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 588858012931 mRNA/rRNA interface [nucleotide binding]; other site 588858012932 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 588858012933 23S rRNA interface [nucleotide binding]; other site 588858012934 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 588858012935 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 588858012936 core dimer interface [polypeptide binding]; other site 588858012937 peripheral dimer interface [polypeptide binding]; other site 588858012938 L10 interface [polypeptide binding]; other site 588858012939 L11 interface [polypeptide binding]; other site 588858012940 putative EF-Tu interaction site [polypeptide binding]; other site 588858012941 putative EF-G interaction site [polypeptide binding]; other site 588858012942 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 588858012943 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 588858012944 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 588858012945 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 588858012946 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 588858012947 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 588858012948 RPB3 interaction site [polypeptide binding]; other site 588858012949 RPB1 interaction site [polypeptide binding]; other site 588858012950 RPB11 interaction site [polypeptide binding]; other site 588858012951 RPB10 interaction site [polypeptide binding]; other site 588858012952 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 588858012953 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 588858012954 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 588858012955 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 588858012956 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 588858012957 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 588858012958 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 588858012959 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 588858012960 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 588858012961 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 588858012962 DNA binding site [nucleotide binding] 588858012963 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 588858012964 type III secretion system protein; Provisional; Region: PRK15384 588858012965 non-LEE encoded effector protein NleB; Provisional; Region: PRK15382 588858012966 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 588858012967 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 588858012968 FeS/SAM binding site; other site 588858012969 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 588858012970 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 588858012971 ThiS interaction site; other site 588858012972 putative active site [active] 588858012973 tetramer interface [polypeptide binding]; other site 588858012974 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 588858012975 thiS-thiF/thiG interaction site; other site 588858012976 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 588858012977 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 588858012978 ATP binding site [chemical binding]; other site 588858012979 substrate interface [chemical binding]; other site 588858012980 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 588858012981 thiamine phosphate binding site [chemical binding]; other site 588858012982 active site 588858012983 pyrophosphate binding site [ion binding]; other site 588858012984 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 588858012985 ThiC-associated domain; Region: ThiC-associated; pfam13667 588858012986 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 588858012987 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 588858012988 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 588858012989 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 588858012990 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 588858012991 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 588858012992 putative NADH binding site [chemical binding]; other site 588858012993 putative active site [active] 588858012994 nudix motif; other site 588858012995 putative metal binding site [ion binding]; other site 588858012996 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 588858012997 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 588858012998 substrate binding site [chemical binding]; other site 588858012999 active site 588858013000 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 588858013001 Active_site [active] 588858013002 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 588858013003 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 588858013004 IHF dimer interface [polypeptide binding]; other site 588858013005 IHF - DNA interface [nucleotide binding]; other site 588858013006 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 588858013007 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 588858013008 dimer interface [polypeptide binding]; other site 588858013009 sensor protein ZraS; Provisional; Region: PRK10364 588858013010 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 588858013011 dimer interface [polypeptide binding]; other site 588858013012 phosphorylation site [posttranslational modification] 588858013013 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 588858013014 ATP binding site [chemical binding]; other site 588858013015 Mg2+ binding site [ion binding]; other site 588858013016 G-X-G motif; other site 588858013017 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 588858013018 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 588858013019 active site 588858013020 phosphorylation site [posttranslational modification] 588858013021 intermolecular recognition site; other site 588858013022 dimerization interface [polypeptide binding]; other site 588858013023 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 588858013024 Walker A motif; other site 588858013025 ATP binding site [chemical binding]; other site 588858013026 Walker B motif; other site 588858013027 arginine finger; other site 588858013028 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 588858013029 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 588858013030 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 588858013031 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 588858013032 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 588858013033 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 588858013034 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 588858013035 purine monophosphate binding site [chemical binding]; other site 588858013036 dimer interface [polypeptide binding]; other site 588858013037 putative catalytic residues [active] 588858013038 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 588858013039 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 588858013040 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 588858013041 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 588858013042 Coenzyme A binding pocket [chemical binding]; other site 588858013043 homoserine O-succinyltransferase; Provisional; Region: PRK05368 588858013044 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 588858013045 proposed active site lysine [active] 588858013046 conserved cys residue [active] 588858013047 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 588858013048 malate synthase A; Region: malate_syn_A; TIGR01344 588858013049 active site 588858013050 isocitrate lyase; Provisional; Region: PRK15063 588858013051 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 588858013052 tetramer interface [polypeptide binding]; other site 588858013053 active site 588858013054 Mg2+/Mn2+ binding site [ion binding]; other site 588858013055 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 588858013056 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 588858013057 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 588858013058 transcriptional repressor IclR; Provisional; Region: PRK11569 588858013059 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 588858013060 Bacterial transcriptional regulator; Region: IclR; pfam01614 588858013061 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 588858013062 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 588858013063 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 588858013064 substrate binding pocket [chemical binding]; other site 588858013065 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 588858013066 B12 binding site [chemical binding]; other site 588858013067 cobalt ligand [ion binding]; other site 588858013068 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 588858013069 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 588858013070 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 588858013071 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 588858013072 active site pocket [active] 588858013073 oxyanion hole [active] 588858013074 catalytic triad [active] 588858013075 active site nucleophile [active] 588858013076 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 588858013077 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 588858013078 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 588858013079 RNA binding surface [nucleotide binding]; other site 588858013080 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 588858013081 probable active site [active] 588858013082 hypothetical protein; Provisional; Region: PRK10515 588858013083 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 588858013084 putative Na+-dependent transporter 588858013085 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 588858013086 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 588858013087 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 588858013088 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 588858013089 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 588858013090 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 588858013091 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 588858013092 Phage-related baseplate assembly protein [General function prediction only]; Region: COG3948 588858013093 Phage baseplate assembly protein W [General function prediction only]; Region: COG3628 588858013094 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 588858013095 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 588858013096 Ligand binding site; other site 588858013097 Putative Catalytic site; other site 588858013098 DXD motif; other site 588858013099 Predicted membrane protein [Function unknown]; Region: COG2246 588858013100 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 588858013101 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 588858013102 Phage protein D [General function prediction only]; Region: COG3500 588858013103 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 588858013104 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 588858013105 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 588858013106 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 588858013107 Phage tail tube protein FII [General function prediction only]; Region: COG3498 588858013108 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 588858013109 Gp37 protein; Region: Gp37; pfam09646 588858013110 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 588858013111 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 588858013112 N-acetyl-D-glucosamine binding site [chemical binding]; other site 588858013113 catalytic residue [active] 588858013114 Protein of unknown function (DUF4063); Region: DUF4063; pfam13272 588858013115 Mor transcription activator family; Region: Mor; pfam08765 588858013116 aspartate kinase III; Validated; Region: PRK09084 588858013117 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 588858013118 nucleotide binding site [chemical binding]; other site 588858013119 substrate binding site [chemical binding]; other site 588858013120 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 588858013121 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 588858013122 dimer interface [polypeptide binding]; other site 588858013123 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 588858013124 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 588858013125 active site 588858013126 dimer interface [polypeptide binding]; other site 588858013127 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 588858013128 dimer interface [polypeptide binding]; other site 588858013129 active site 588858013130 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 588858013131 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 588858013132 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 588858013133 Predicted membrane protein [Function unknown]; Region: COG3223 588858013134 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 588858013135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858013136 dimer interface [polypeptide binding]; other site 588858013137 conserved gate region; other site 588858013138 putative PBP binding loops; other site 588858013139 ABC-ATPase subunit interface; other site 588858013140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 588858013141 dimer interface [polypeptide binding]; other site 588858013142 conserved gate region; other site 588858013143 putative PBP binding loops; other site 588858013144 ABC-ATPase subunit interface; other site 588858013145 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 588858013146 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 588858013147 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 588858013148 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 588858013149 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 588858013150 Walker A/P-loop; other site 588858013151 ATP binding site [chemical binding]; other site 588858013152 Q-loop/lid; other site 588858013153 ABC transporter signature motif; other site 588858013154 Walker B; other site 588858013155 D-loop; other site 588858013156 H-loop/switch region; other site 588858013157 TOBE domain; Region: TOBE_2; pfam08402 588858013158 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 588858013159 trimer interface; other site 588858013160 sugar binding site [chemical binding]; other site 588858013161 maltose regulon periplasmic protein; Provisional; Region: PRK10564 588858013162 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 588858013163 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 588858013164 UbiA prenyltransferase family; Region: UbiA; pfam01040 588858013165 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 588858013166 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 588858013167 putative acyl-acceptor binding pocket; other site 588858013168 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 588858013169 LexA repressor; Validated; Region: PRK00215 588858013170 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 588858013171 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 588858013172 Catalytic site [active] 588858013173 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 588858013174 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 588858013175 hypothetical protein; Provisional; Region: PRK10428 588858013176 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 588858013177 metal binding site 2 [ion binding]; metal-binding site 588858013178 putative DNA binding helix; other site 588858013179 metal binding site 1 [ion binding]; metal-binding site 588858013180 dimer interface [polypeptide binding]; other site 588858013181 structural Zn2+ binding site [ion binding]; other site 588858013182 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 588858013183 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 588858013184 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 588858013185 FMN binding site [chemical binding]; other site 588858013186 active site 588858013187 catalytic residues [active] 588858013188 substrate binding site [chemical binding]; other site 588858013189 phage shock protein G; Reviewed; Region: pspG; PRK09459 588858013190 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 588858013191 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 588858013192 NADP binding site [chemical binding]; other site 588858013193 dimer interface [polypeptide binding]; other site 588858013194 replicative DNA helicase; Provisional; Region: PRK08006 588858013195 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 588858013196 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 588858013197 Walker A motif; other site 588858013198 ATP binding site [chemical binding]; other site 588858013199 Walker B motif; other site 588858013200 DNA binding loops [nucleotide binding] 588858013201 alanine racemase; Reviewed; Region: alr; PRK00053 588858013202 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 588858013203 active site 588858013204 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 588858013205 substrate binding site [chemical binding]; other site 588858013206 catalytic residues [active] 588858013207 dimer interface [polypeptide binding]; other site 588858013208 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 588858013209 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 588858013210 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858013211 homodimer interface [polypeptide binding]; other site 588858013212 catalytic residue [active] 588858013213 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 588858013214 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 588858013215 active site 588858013216 motif I; other site 588858013217 motif II; other site 588858013218 Uncharacterized conserved protein [Function unknown]; Region: COG0432 588858013219 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 588858013220 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 588858013221 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 588858013222 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 588858013223 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 588858013224 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 588858013225 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 588858013226 dimer interface [polypeptide binding]; other site 588858013227 ssDNA binding site [nucleotide binding]; other site 588858013228 tetramer (dimer of dimers) interface [polypeptide binding]; other site 588858013229 hypothetical protein; Validated; Region: PRK09039 588858013230 Zinc finger-containing protein; Region: zf-C4H2; pfam10146 588858013231 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 588858013232 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 588858013233 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 588858013234 HlyD family secretion protein; Region: HlyD_3; pfam13437 588858013235 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 588858013236 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 588858013237 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 588858013238 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 588858013239 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 588858013240 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 588858013241 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 588858013242 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 588858013243 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 588858013244 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 588858013245 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 588858013246 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 588858013247 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 588858013248 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 588858013249 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 588858013250 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 588858013251 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 588858013252 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 588858013253 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 588858013254 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 588858013255 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 588858013256 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 588858013257 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 588858013258 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 588858013259 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 588858013260 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 588858013261 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 588858013262 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 588858013263 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 588858013264 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 588858013265 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 588858013266 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 588858013267 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 588858013268 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 588858013269 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 588858013270 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 588858013271 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 588858013272 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 588858013273 Bacterial Ig-like domain (group 3); Region: Big_3_2; pfam12245 588858013274 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 588858013275 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 588858013276 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 588858013277 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 588858013278 Walker A/P-loop; other site 588858013279 ATP binding site [chemical binding]; other site 588858013280 Q-loop/lid; other site 588858013281 ABC transporter signature motif; other site 588858013282 Walker B; other site 588858013283 D-loop; other site 588858013284 H-loop/switch region; other site 588858013285 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 588858013286 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 588858013287 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 588858013288 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 588858013289 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 588858013290 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 588858013291 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 588858013292 DNA binding residues [nucleotide binding] 588858013293 dimer interface [polypeptide binding]; other site 588858013294 [2Fe-2S] cluster binding site [ion binding]; other site 588858013295 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 588858013296 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 588858013297 putative C-terminal domain interface [polypeptide binding]; other site 588858013298 putative GSH binding site (G-site) [chemical binding]; other site 588858013299 putative dimer interface [polypeptide binding]; other site 588858013300 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 588858013301 putative N-terminal domain interface [polypeptide binding]; other site 588858013302 putative dimer interface [polypeptide binding]; other site 588858013303 putative substrate binding pocket (H-site) [chemical binding]; other site 588858013304 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 588858013305 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 588858013306 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 588858013307 Transcriptional regulator [Transcription]; Region: LysR; COG0583 588858013308 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858013309 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 588858013310 putative dimerization interface [polypeptide binding]; other site 588858013311 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 588858013312 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 588858013313 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 588858013314 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 588858013315 Na binding site [ion binding]; other site 588858013316 Predicted membrane protein [Function unknown]; Region: COG3162 588858013317 acetyl-CoA synthetase; Provisional; Region: PRK00174 588858013318 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 588858013319 active site 588858013320 CoA binding site [chemical binding]; other site 588858013321 acyl-activating enzyme (AAE) consensus motif; other site 588858013322 AMP binding site [chemical binding]; other site 588858013323 acetate binding site [chemical binding]; other site 588858013324 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 588858013325 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 588858013326 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 588858013327 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 588858013328 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 588858013329 heme lyase subunit NrfE; Provisional; Region: PRK10369 588858013330 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 588858013331 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 588858013332 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 588858013333 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 588858013334 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 588858013335 Sel1-like repeats; Region: SEL1; smart00671 588858013336 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 588858013337 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 588858013338 [4Fe-4S] binding site [ion binding]; other site 588858013339 molybdopterin cofactor binding site; other site 588858013340 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 588858013341 molybdopterin cofactor binding site; other site 588858013342 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 588858013343 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 588858013344 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 588858013345 Coenzyme A binding pocket [chemical binding]; other site 588858013346 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 588858013347 dimer interface [polypeptide binding]; other site 588858013348 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 588858013349 hypothetical protein; Provisional; Region: PRK10220 588858013350 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 588858013351 PhnA protein; Region: PhnA; pfam03831 588858013352 proline/glycine betaine transporter; Provisional; Region: PRK10642 588858013353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858013354 putative substrate translocation pore; other site 588858013355 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 588858013356 sensor protein BasS/PmrB; Provisional; Region: PRK10755 588858013357 HAMP domain; Region: HAMP; pfam00672 588858013358 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 588858013359 dimer interface [polypeptide binding]; other site 588858013360 phosphorylation site [posttranslational modification] 588858013361 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 588858013362 ATP binding site [chemical binding]; other site 588858013363 Mg2+ binding site [ion binding]; other site 588858013364 G-X-G motif; other site 588858013365 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 588858013366 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 588858013367 active site 588858013368 phosphorylation site [posttranslational modification] 588858013369 intermolecular recognition site; other site 588858013370 dimerization interface [polypeptide binding]; other site 588858013371 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 588858013372 DNA binding site [nucleotide binding] 588858013373 putative metal dependent hydrolase; Provisional; Region: PRK11598 588858013374 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 588858013375 Sulfatase; Region: Sulfatase; pfam00884 588858013376 arginine:agmatin antiporter; Provisional; Region: PRK10644 588858013377 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 588858013378 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 588858013379 arginine decarboxylase; Provisional; Region: PRK15029 588858013380 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 588858013381 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 588858013382 homodimer interface [polypeptide binding]; other site 588858013383 pyridoxal 5'-phosphate binding site [chemical binding]; other site 588858013384 catalytic residue [active] 588858013385 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 588858013386 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 588858013387 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 588858013388 alpha-galactosidase; Provisional; Region: PRK15076 588858013389 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 588858013390 NAD binding site [chemical binding]; other site 588858013391 sugar binding site [chemical binding]; other site 588858013392 divalent metal binding site [ion binding]; other site 588858013393 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 588858013394 dimer interface [polypeptide binding]; other site 588858013395 melibiose:sodium symporter; Provisional; Region: PRK10429 588858013396 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 588858013397 fumarate hydratase; Provisional; Region: PRK15389 588858013398 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 588858013399 Fumarase C-terminus; Region: Fumerase_C; pfam05683 588858013400 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 588858013401 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 588858013402 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 588858013403 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 588858013404 active site 588858013405 phosphorylation site [posttranslational modification] 588858013406 intermolecular recognition site; other site 588858013407 dimerization interface [polypeptide binding]; other site 588858013408 sensory histidine kinase DcuS; Provisional; Region: PRK11086 588858013409 PAS domain; Region: PAS; smart00091 588858013410 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 588858013411 ATP binding site [chemical binding]; other site 588858013412 Mg2+ binding site [ion binding]; other site 588858013413 G-X-G motif; other site 588858013414 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 588858013415 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 588858013416 putative [Fe4-S4] binding site [ion binding]; other site 588858013417 putative molybdopterin cofactor binding site [chemical binding]; other site 588858013418 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 588858013419 putative molybdopterin cofactor binding site; other site 588858013420 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 588858013421 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 588858013422 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 588858013423 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 588858013424 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 588858013425 SdiA-regulated; Region: SdiA-regulated; cd09971 588858013426 putative active site [active] 588858013427 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 588858013428 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 588858013429 DNA binding residues [nucleotide binding] 588858013430 dimerization interface [polypeptide binding]; other site 588858013431 AraC family transcriptional regulator; Provisional; Region: PRK15186 588858013432 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 588858013433 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 588858013434 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 588858013435 Coenzyme A binding pocket [chemical binding]; other site 588858013436 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 588858013437 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 588858013438 active site 588858013439 EthD domain; Region: EthD; pfam07110 588858013440 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 588858013441 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 588858013442 DNA binding residues [nucleotide binding] 588858013443 putative dimer interface [polypeptide binding]; other site 588858013444 putative transcriptional regulator; Provisional; Region: PRK11640 588858013445 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 588858013446 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 588858013447 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 588858013448 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 588858013449 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 588858013450 DsbD alpha interface [polypeptide binding]; other site 588858013451 catalytic residues [active] 588858013452 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 588858013453 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 588858013454 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 588858013455 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 588858013456 Aspartase; Region: Aspartase; cd01357 588858013457 active sites [active] 588858013458 tetramer interface [polypeptide binding]; other site 588858013459 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 588858013460 putative transporter; Provisional; Region: PRK11021 588858013461 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 588858013462 oligomerisation interface [polypeptide binding]; other site 588858013463 mobile loop; other site 588858013464 roof hairpin; other site 588858013465 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 588858013466 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 588858013467 ring oligomerisation interface [polypeptide binding]; other site 588858013468 ATP/Mg binding site [chemical binding]; other site 588858013469 stacking interactions; other site 588858013470 hinge regions; other site 588858013471 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 588858013472 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 588858013473 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 588858013474 FeS/SAM binding site; other site 588858013475 elongation factor P; Validated; Region: PRK00529 588858013476 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 588858013477 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 588858013478 RNA binding site [nucleotide binding]; other site 588858013479 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 588858013480 RNA binding site [nucleotide binding]; other site 588858013481 Predicted small secreted protein [Function unknown]; Region: COG5510 588858013482 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 588858013483 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 588858013484 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 588858013485 DNA binding residues [nucleotide binding] 588858013486 dimerization interface [polypeptide binding]; other site 588858013487 multidrug efflux system protein; Provisional; Region: PRK11431 588858013488 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 588858013489 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 588858013490 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 588858013491 Iron-sulfur protein interface; other site 588858013492 proximal quinone binding site [chemical binding]; other site 588858013493 C-subunit interface; other site 588858013494 distal quinone binding site; other site 588858013495 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 588858013496 D-subunit interface [polypeptide binding]; other site 588858013497 Iron-sulfur protein interface; other site 588858013498 proximal quinone binding site [chemical binding]; other site 588858013499 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 588858013500 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 588858013501 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 588858013502 L-aspartate oxidase; Provisional; Region: PRK06175 588858013503 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 588858013504 poxB regulator PoxA; Provisional; Region: PRK09350 588858013505 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 588858013506 motif 1; other site 588858013507 dimer interface [polypeptide binding]; other site 588858013508 active site 588858013509 motif 2; other site 588858013510 motif 3; other site 588858013511 inner membrane transporter YjeM; Provisional; Region: PRK15238 588858013512 Protein of unknown function (DUF2645); Region: DUF2645; pfam10840 588858013513 putative mechanosensitive channel protein; Provisional; Region: PRK10929 588858013514 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 588858013515 Mechanosensitive ion channel; Region: MS_channel; pfam00924 588858013516 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 588858013517 GTPase RsgA; Reviewed; Region: PRK12288 588858013518 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 588858013519 RNA binding site [nucleotide binding]; other site 588858013520 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 588858013521 GTPase/Zn-binding domain interface [polypeptide binding]; other site 588858013522 GTP/Mg2+ binding site [chemical binding]; other site 588858013523 G4 box; other site 588858013524 G5 box; other site 588858013525 G1 box; other site 588858013526 Switch I region; other site 588858013527 G2 box; other site 588858013528 G3 box; other site 588858013529 Switch II region; other site 588858013530 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 588858013531 catalytic site [active] 588858013532 putative active site [active] 588858013533 putative substrate binding site [chemical binding]; other site 588858013534 dimer interface [polypeptide binding]; other site 588858013535 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 588858013536 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 588858013537 substrate binding pocket [chemical binding]; other site 588858013538 membrane-bound complex binding site; other site 588858013539 hinge residues; other site 588858013540 epoxyqueuosine reductase; Region: TIGR00276 588858013541 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 588858013542 putative carbohydrate kinase; Provisional; Region: PRK10565 588858013543 Uncharacterized conserved protein [Function unknown]; Region: COG0062 588858013544 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 588858013545 putative substrate binding site [chemical binding]; other site 588858013546 putative ATP binding site [chemical binding]; other site 588858013547 ADP-binding protein; Provisional; Region: PRK10646 588858013548 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 588858013549 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 588858013550 active site 588858013551 metal binding site [ion binding]; metal-binding site 588858013552 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 588858013553 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 588858013554 ATP binding site [chemical binding]; other site 588858013555 Mg2+ binding site [ion binding]; other site 588858013556 G-X-G motif; other site 588858013557 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 588858013558 ATP binding site [chemical binding]; other site 588858013559 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 588858013560 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 588858013561 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 588858013562 bacterial Hfq-like; Region: Hfq; cd01716 588858013563 hexamer interface [polypeptide binding]; other site 588858013564 Sm1 motif; other site 588858013565 RNA binding site [nucleotide binding]; other site 588858013566 Sm2 motif; other site 588858013567 GTPase HflX; Provisional; Region: PRK11058 588858013568 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 588858013569 HflX GTPase family; Region: HflX; cd01878 588858013570 G1 box; other site 588858013571 GTP/Mg2+ binding site [chemical binding]; other site 588858013572 Switch I region; other site 588858013573 G2 box; other site 588858013574 G3 box; other site 588858013575 Switch II region; other site 588858013576 G4 box; other site 588858013577 G5 box; other site 588858013578 FtsH protease regulator HflK; Provisional; Region: PRK10930 588858013579 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 588858013580 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 588858013581 FtsH protease regulator HflC; Provisional; Region: PRK11029 588858013582 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 588858013583 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 588858013584 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 588858013585 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 588858013586 GDP-binding site [chemical binding]; other site 588858013587 ACT binding site; other site 588858013588 IMP binding site; other site 588858013589 Predicted transcriptional regulator [Transcription]; Region: COG1959 588858013590 transcriptional repressor NsrR; Provisional; Region: PRK11014 588858013591 exoribonuclease R; Provisional; Region: PRK11642 588858013592 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 588858013593 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 588858013594 RNB domain; Region: RNB; pfam00773 588858013595 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 588858013596 RNA binding site [nucleotide binding]; other site 588858013597 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 588858013598 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 588858013599 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 588858013600 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3789 588858013601 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 588858013602 Ion channel; Region: Ion_trans_2; pfam07885 588858013603 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 588858013604 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 588858013605 Predicted membrane protein [Function unknown]; Region: COG3766 588858013606 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 588858013607 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 588858013608 Predicted integral membrane protein [Function unknown]; Region: COG5463 588858013609 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 588858013610 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 588858013611 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 588858013612 FAD binding site [chemical binding]; other site 588858013613 substrate binding site [chemical binding]; other site 588858013614 catalytic residues [active] 588858013615 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 588858013616 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 588858013617 esterase; Provisional; Region: PRK10566 588858013618 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 588858013619 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 588858013620 transcriptional repressor UlaR; Provisional; Region: PRK13509 588858013621 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 588858013622 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 588858013623 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 588858013624 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 588858013625 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 588858013626 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 588858013627 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 588858013628 active site 588858013629 P-loop; other site 588858013630 phosphorylation site [posttranslational modification] 588858013631 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 588858013632 active site 588858013633 phosphorylation site [posttranslational modification] 588858013634 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 588858013635 active site 588858013636 dimer interface [polypeptide binding]; other site 588858013637 magnesium binding site [ion binding]; other site 588858013638 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 588858013639 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 588858013640 AP (apurinic/apyrimidinic) site pocket; other site 588858013641 DNA interaction; other site 588858013642 Metal-binding active site; metal-binding site 588858013643 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 588858013644 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 588858013645 intersubunit interface [polypeptide binding]; other site 588858013646 active site 588858013647 Zn2+ binding site [ion binding]; other site 588858013648 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 588858013649 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 588858013650 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 588858013651 dimer interface [polypeptide binding]; other site 588858013652 ssDNA binding site [nucleotide binding]; other site 588858013653 tetramer (dimer of dimers) interface [polypeptide binding]; other site 588858013654 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 588858013655 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 588858013656 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 588858013657 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 588858013658 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 588858013659 EamA-like transporter family; Region: EamA; pfam00892 588858013660 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 588858013661 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 588858013662 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 588858013663 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 588858013664 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 588858013665 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 588858013666 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 588858013667 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 588858013668 Hemerythrin-like domain; Region: Hr-like; cd12108 588858013669 Fe binding site [ion binding]; other site 588858013670 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 588858013671 EamA-like transporter family; Region: EamA; pfam00892 588858013672 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 588858013673 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 588858013674 NADP binding site [chemical binding]; other site 588858013675 Predicted transcriptional regulators [Transcription]; Region: COG1733 588858013676 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 588858013677 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 588858013678 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 588858013679 active site 588858013680 metal binding site [ion binding]; metal-binding site 588858013681 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 588858013682 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 588858013683 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 588858013684 active site 588858013685 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 588858013686 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 588858013687 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 588858013688 Domain of unknown function DUF21; Region: DUF21; pfam01595 588858013689 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 588858013690 Transporter associated domain; Region: CorC_HlyC; smart01091 588858013691 methionine sulfoxide reductase A; Provisional; Region: PRK00058 588858013692 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 588858013693 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 588858013694 Surface antigen; Region: Bac_surface_Ag; pfam01103 588858013695 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 588858013696 Family of unknown function (DUF490); Region: DUF490; pfam04357 588858013697 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 588858013698 putative active site pocket [active] 588858013699 dimerization interface [polypeptide binding]; other site 588858013700 putative catalytic residue [active] 588858013701 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858013702 D-galactonate transporter; Region: 2A0114; TIGR00893 588858013703 putative substrate translocation pore; other site 588858013704 putative metallo-dependent hydrolase; Provisional; Region: PRK12394 588858013705 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 588858013706 active site 588858013707 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 588858013708 dimer interface [polypeptide binding]; other site 588858013709 substrate binding site [chemical binding]; other site 588858013710 metal binding sites [ion binding]; metal-binding site 588858013711 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 588858013712 AMP binding site [chemical binding]; other site 588858013713 metal binding site [ion binding]; metal-binding site 588858013714 active site 588858013715 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 588858013716 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 588858013717 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 588858013718 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 588858013719 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 588858013720 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 588858013721 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 588858013722 putative active site [active] 588858013723 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 588858013724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858013725 putative substrate translocation pore; other site 588858013726 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858013727 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 588858013728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858013729 putative substrate translocation pore; other site 588858013730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858013731 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 588858013732 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 588858013733 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 588858013734 tetrameric interface [polypeptide binding]; other site 588858013735 NAD binding site [chemical binding]; other site 588858013736 catalytic residues [active] 588858013737 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 588858013738 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 588858013739 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 588858013740 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 588858013741 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 588858013742 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 588858013743 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 588858013744 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 588858013745 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 588858013746 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 588858013747 major facilitator superfamily transporter; Provisional; Region: PRK05122 588858013748 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858013749 putative substrate translocation pore; other site 588858013750 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 588858013751 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 588858013752 substrate binding site [chemical binding]; other site 588858013753 ATP binding site [chemical binding]; other site 588858013754 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 588858013755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 588858013756 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 588858013757 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 588858013758 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 588858013759 polyol permease family; Region: 2A0118; TIGR00897 588858013760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858013761 putative substrate translocation pore; other site 588858013762 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 588858013763 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 588858013764 DNA interaction; other site 588858013765 Metal-binding active site; metal-binding site 588858013766 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 588858013767 hypothetical protein; Provisional; Region: PRK05255 588858013768 peptidase PmbA; Provisional; Region: PRK11040 588858013769 cytochrome b562; Provisional; Region: PRK15058 588858013770 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 588858013771 conserved hypothetical protein EF_0830/AHA_3911; Region: EF_0830; TIGR03577 588858013772 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 588858013773 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 588858013774 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 588858013775 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 588858013776 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 588858013777 active site 588858013778 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 588858013779 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 588858013780 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 588858013781 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 588858013782 HTH domain; Region: HTH_11; pfam08279 588858013783 Mga helix-turn-helix domain; Region: Mga; pfam05043 588858013784 PRD domain; Region: PRD; pfam00874 588858013785 PRD domain; Region: PRD; pfam00874 588858013786 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 588858013787 active site 588858013788 P-loop; other site 588858013789 phosphorylation site [posttranslational modification] 588858013790 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 588858013791 active site 588858013792 phosphorylation site [posttranslational modification] 588858013793 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 588858013794 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 588858013795 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 588858013796 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 588858013797 FeS/SAM binding site; other site 588858013798 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 588858013799 ATP cone domain; Region: ATP-cone; pfam03477 588858013800 Class III ribonucleotide reductase; Region: RNR_III; cd01675 588858013801 effector binding site; other site 588858013802 active site 588858013803 Zn binding site [ion binding]; other site 588858013804 glycine loop; other site 588858013805 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 588858013806 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 588858013807 Ca binding site [ion binding]; other site 588858013808 active site 588858013809 catalytic site [active] 588858013810 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 588858013811 pseudogene; frameshift 588858013812 trehalose repressor; Provisional; Region: treR; PRK09492 588858013813 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 588858013814 DNA binding site [nucleotide binding] 588858013815 domain linker motif; other site 588858013816 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 588858013817 dimerization interface [polypeptide binding]; other site 588858013818 ligand binding site [chemical binding]; other site 588858013819 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 588858013820 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 588858013821 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 588858013822 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 588858013823 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 588858013824 Soluble P-type ATPase [General function prediction only]; Region: COG4087 588858013825 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 588858013826 Transposase; Region: HTH_Tnp_1; cl17663 588858013827 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 588858013828 homotrimer interaction site [polypeptide binding]; other site 588858013829 putative active site [active] 588858013830 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 588858013831 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 588858013832 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 588858013833 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 588858013834 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 588858013835 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 588858013836 pyrBI operon leader peptide; Provisional; Region: PRK10224 588858013837 Arginine repressor [Transcription]; Region: ArgR; COG1438 588858013838 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 588858013839 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 588858013840 Predicted membrane protein [Function unknown]; Region: COG1288 588858013841 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 588858013842 ornithine carbamoyltransferase; Validated; Region: PRK02102 588858013843 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 588858013844 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 588858013845 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 588858013846 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 588858013847 putative substrate binding site [chemical binding]; other site 588858013848 nucleotide binding site [chemical binding]; other site 588858013849 nucleotide binding site [chemical binding]; other site 588858013850 homodimer interface [polypeptide binding]; other site 588858013851 arginine deiminase; Provisional; Region: PRK01388 588858013852 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 588858013853 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 588858013854 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 588858013855 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 588858013856 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 588858013857 RNase E inhibitor protein; Provisional; Region: PRK11191 588858013858 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 588858013859 active site 588858013860 dinuclear metal binding site [ion binding]; other site 588858013861 dimerization interface [polypeptide binding]; other site 588858013862 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 588858013863 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 588858013864 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 588858013865 Coenzyme A binding pocket [chemical binding]; other site 588858013866 Predicted membrane protein [Function unknown]; Region: COG4269 588858013867 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 588858013868 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 588858013869 HIGH motif; other site 588858013870 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 588858013871 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 588858013872 active site 588858013873 KMSKS motif; other site 588858013874 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 588858013875 tRNA binding surface [nucleotide binding]; other site 588858013876 anticodon binding site; other site 588858013877 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 588858013878 DNA polymerase III subunit chi; Validated; Region: PRK05728 588858013879 multifunctional aminopeptidase A; Provisional; Region: PRK00913 588858013880 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 588858013881 interface (dimer of trimers) [polypeptide binding]; other site 588858013882 Substrate-binding/catalytic site; other site 588858013883 Zn-binding sites [ion binding]; other site 588858013884 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 588858013885 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 588858013886 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 588858013887 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 588858013888 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 588858013889 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 588858013890 DNA binding site [nucleotide binding] 588858013891 domain linker motif; other site 588858013892 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 588858013893 putative dimerization interface [polypeptide binding]; other site 588858013894 putative ligand binding site [chemical binding]; other site 588858013895 gluconate transporter; Region: gntP; TIGR00791 588858013896 fructuronate transporter; Provisional; Region: PRK10034; cl15264 588858013897 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 588858013898 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 588858013899 NADP binding site [chemical binding]; other site 588858013900 homodimer interface [polypeptide binding]; other site 588858013901 active site 588858013902 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 588858013903 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 588858013904 putative NAD(P) binding site [chemical binding]; other site 588858013905 catalytic Zn binding site [ion binding]; other site 588858013906 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 588858013907 ATP-binding site [chemical binding]; other site 588858013908 Gluconate-6-phosphate binding site [chemical binding]; other site 588858013909 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 588858013910 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 588858013911 putative NAD(P) binding site [chemical binding]; other site 588858013912 putative substrate binding site [chemical binding]; other site 588858013913 catalytic Zn binding site [ion binding]; other site 588858013914 structural Zn binding site [ion binding]; other site 588858013915 dimer interface [polypeptide binding]; other site 588858013916 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 588858013917 Part of AAA domain; Region: AAA_19; pfam13245 588858013918 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 588858013919 AAA domain; Region: AAA_12; pfam13087 588858013920 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 588858013921 putative active site [active] 588858013922 catalytic site [active] 588858013923 Uncharacterized conserved protein [Function unknown]; Region: COG4127 588858013924 Restriction endonuclease; Region: Mrr_cat; pfam04471 588858013925 conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653 588858013926 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 588858013927 TIGR02687 family protein; Region: TIGR02687 588858013928 PglZ domain; Region: PglZ; pfam08665 588858013929 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 588858013930 AAA domain; Region: AAA_21; pfam13304 588858013931 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 588858013932 Walker A/P-loop; other site 588858013933 Walker A/P-loop; other site 588858013934 ATP binding site [chemical binding]; other site 588858013935 ATP binding site [chemical binding]; other site 588858013936 Q-loop/lid; other site 588858013937 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 588858013938 Methyltransferase domain; Region: Methyltransf_26; pfam13659 588858013939 TIGR02680 family protein; Region: TIGR02680 588858013940 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 588858013941 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 588858013942 hypothetical protein; Provisional; Region: PRK12378 588858013943 Methyltransferase domain; Region: Methyltransf_23; pfam13489 588858013944 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 588858013945 S-adenosylmethionine binding site [chemical binding]; other site 588858013946 Methyltransferase domain; Region: Methyltransf_31; pfam13847 588858013947 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 588858013948 S-adenosylmethionine binding site [chemical binding]; other site 588858013949 hypothetical protein; Provisional; Region: PRK13687 588858013950 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4332 588858013951 Protein of unknown function DUF91; Region: DUF91; cl00709 588858013952 Uncharacterized conserved protein [Function unknown]; Region: COG3439 588858013953 Dienelactone hydrolase family; Region: DLH; pfam01738 588858013954 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 588858013955 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 588858013956 DNA-binding site [nucleotide binding]; DNA binding site 588858013957 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 588858013958 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 588858013959 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 588858013960 active site 588858013961 HIGH motif; other site 588858013962 dimer interface [polypeptide binding]; other site 588858013963 KMSKS motif; other site 588858013964 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 588858013965 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 588858013966 aspartate racemase; Region: asp_race; TIGR00035 588858013967 cell density-dependent motility repressor; Provisional; Region: PRK10082 588858013968 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 588858013969 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 588858013970 dimerization interface [polypeptide binding]; other site 588858013971 isoaspartyl dipeptidase; Provisional; Region: PRK10657 588858013972 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 588858013973 active site 588858013974 hypothetical protein; Provisional; Region: PRK10519 588858013975 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 588858013976 Nucleoside recognition; Region: Gate; pfam07670 588858013977 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 588858013978 Predicted membrane protein [Function unknown]; Region: COG2733 588858013979 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 588858013980 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 588858013981 putative substrate translocation pore; other site 588858013982 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 588858013983 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 588858013984 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 588858013985 NAD(P) binding site [chemical binding]; other site 588858013986 catalytic residues [active] 588858013987 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 588858013988 endoribonuclease SymE; Provisional; Region: PRK13605 588858013989 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 588858013990 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 588858013991 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 588858013992 HsdM N-terminal domain; Region: HsdM_N; pfam12161 588858013993 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 588858013994 Methyltransferase domain; Region: Methyltransf_26; pfam13659 588858013995 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 588858013996 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 588858013997 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 588858013998 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 588858013999 ATP binding site [chemical binding]; other site 588858014000 putative Mg++ binding site [ion binding]; other site 588858014001 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 588858014002 Mrr N-terminal domain; Region: Mrr_N; pfam14338 588858014003 Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; Region: CH; cl00030 588858014004 Restriction endonuclease; Region: Mrr_cat; pfam04471 588858014005 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929 588858014006 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514 588858014007 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 588858014008 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 588858014009 P-loop, Walker A motif; other site 588858014010 Base recognition motif; other site 588858014011 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 588858014012 Uncharacterized small protein [Function unknown]; Region: COG2879 588858014013 carbon starvation protein A; Provisional; Region: PRK15015 588858014014 Carbon starvation protein CstA; Region: CstA; pfam02554 588858014015 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 588858014016 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 588858014017 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 588858014018 dimer interface [polypeptide binding]; other site 588858014019 ligand binding site [chemical binding]; other site 588858014020 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 588858014021 dimerization interface [polypeptide binding]; other site 588858014022 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 588858014023 dimer interface [polypeptide binding]; other site 588858014024 putative CheW interface [polypeptide binding]; other site 588858014025 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 588858014026 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 588858014027 Walker A motif; other site 588858014028 ATP binding site [chemical binding]; other site 588858014029 Walker B motif; other site 588858014030 arginine finger; other site 588858014031 Transcriptional antiterminator [Transcription]; Region: COG3933 588858014032 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 588858014033 active pocket/dimerization site; other site 588858014034 active site 588858014035 phosphorylation site [posttranslational modification] 588858014036 PRD domain; Region: PRD; pfam00874 588858014037 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 588858014038 active pocket/dimerization site; other site 588858014039 active site 588858014040 phosphorylation site [posttranslational modification] 588858014041 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 588858014042 active site 588858014043 phosphorylation site [posttranslational modification] 588858014044 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 588858014045 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 588858014046 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 588858014047 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 588858014048 dimer interface [polypeptide binding]; other site 588858014049 active site 588858014050 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 588858014051 dimer interface [polypeptide binding]; other site 588858014052 active site 588858014053 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 588858014054 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 588858014055 putative active site [active] 588858014056 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 588858014057 phosphoglycerol transferase I; Provisional; Region: PRK03776 588858014058 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 588858014059 hypothetical protein; Provisional; Region: PRK11667 588858014060 DNA replication protein DnaC; Validated; Region: PRK07952 588858014061 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 588858014062 Walker A motif; other site 588858014063 ATP binding site [chemical binding]; other site 588858014064 Walker B motif; other site 588858014065 primosomal protein DnaI; Provisional; Region: PRK02854 588858014066 hypothetical protein; Provisional; Region: PRK09917 588858014067 Uncharacterized conserved protein [Function unknown]; Region: COG2966 588858014068 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 588858014069 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 588858014070 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 588858014071 DNA binding residues [nucleotide binding] 588858014072 dimerization interface [polypeptide binding]; other site 588858014073 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 588858014074 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 588858014075 DNA binding residues [nucleotide binding] 588858014076 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 588858014077 putative deacylase active site [active] 588858014078 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 588858014079 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 588858014080 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 588858014081 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 588858014082 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 588858014083 metal binding site [ion binding]; metal-binding site 588858014084 active site 588858014085 I-site; other site 588858014086 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 588858014087 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 588858014088 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 588858014089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 588858014090 S-adenosylmethionine binding site [chemical binding]; other site 588858014091 DNA polymerase III subunit psi; Validated; Region: PRK06856 588858014092 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 588858014093 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 588858014094 Coenzyme A binding pocket [chemical binding]; other site 588858014095 dUMP phosphatase; Provisional; Region: PRK09449 588858014096 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 588858014097 motif II; other site 588858014098 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 588858014099 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 588858014100 G1 box; other site 588858014101 putative GEF interaction site [polypeptide binding]; other site 588858014102 GTP/Mg2+ binding site [chemical binding]; other site 588858014103 Switch I region; other site 588858014104 G2 box; other site 588858014105 G3 box; other site 588858014106 Switch II region; other site 588858014107 G4 box; other site 588858014108 G5 box; other site 588858014109 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 588858014110 periplasmic protein; Provisional; Region: PRK10568 588858014111 BON domain; Region: BON; pfam04972 588858014112 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 588858014113 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 588858014114 active site 588858014115 nucleophile elbow; other site 588858014116 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 588858014117 active site 588858014118 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 588858014119 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 588858014120 FeS/SAM binding site; other site 588858014121 hypothetical protein; Provisional; Region: PRK10977 588858014122 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 588858014123 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 588858014124 intersubunit interface [polypeptide binding]; other site 588858014125 active site 588858014126 catalytic residue [active] 588858014127 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 588858014128 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 588858014129 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 588858014130 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 588858014131 phosphopentomutase; Provisional; Region: PRK05362 588858014132 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 588858014133 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 588858014134 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 588858014135 hypothetical protein; Provisional; Region: PRK15301 588858014136 putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304 588858014137 PapC N-terminal domain; Region: PapC_N; pfam13954 588858014138 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 588858014139 PapC C-terminal domain; Region: PapC_C; pfam13953 588858014140 putative fimbrial chaperone protein; Provisional; Region: PRK09918 588858014141 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 588858014142 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 588858014143 hypothetical protein; Provisional; Region: PRK15302 588858014144 hypothetical protein; Provisional; Region: PRK15303 588858014145 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 588858014146 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 588858014147 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 588858014148 hypothetical protein; Provisional; Region: PRK11246 588858014149 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 588858014150 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 588858014151 motif II; other site 588858014152 DNA repair protein RadA; Region: sms; TIGR00416 588858014153 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 588858014154 Walker A motif/ATP binding site; other site 588858014155 ATP binding site [chemical binding]; other site 588858014156 Walker B motif; other site 588858014157 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 588858014158 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 588858014159 non-specific DNA binding site [nucleotide binding]; other site 588858014160 salt bridge; other site 588858014161 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 588858014162 sequence-specific DNA binding site [nucleotide binding]; other site 588858014163 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 588858014164 active site 588858014165 (T/H)XGH motif; other site 588858014166 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 588858014167 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 588858014168 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 588858014169 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 588858014170 ABC transporter; Region: ABC_tran_2; pfam12848 588858014171 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 588858014172 lytic murein transglycosylase; Provisional; Region: PRK11619 588858014173 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 588858014174 N-acetyl-D-glucosamine binding site [chemical binding]; other site 588858014175 catalytic residue [active] 588858014176 Trp operon repressor; Provisional; Region: PRK01381 588858014177 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 588858014178 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 588858014179 catalytic core [active] 588858014180 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 588858014181 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 588858014182 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 588858014183 hypothetical protein; Provisional; Region: PRK10756 588858014184 CreA protein; Region: CreA; pfam05981 588858014185 DNA-binding response regulator CreB; Provisional; Region: PRK11083 588858014186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 588858014187 active site 588858014188 phosphorylation site [posttranslational modification] 588858014189 intermolecular recognition site; other site 588858014190 dimerization interface [polypeptide binding]; other site 588858014191 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 588858014192 DNA binding site [nucleotide binding] 588858014193 sensory histidine kinase CreC; Provisional; Region: PRK11100 588858014194 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 588858014195 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 588858014196 dimer interface [polypeptide binding]; other site 588858014197 phosphorylation site [posttranslational modification] 588858014198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 588858014199 ATP binding site [chemical binding]; other site 588858014200 Mg2+ binding site [ion binding]; other site 588858014201 G-X-G motif; other site 588858014202 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 588858014203 putative major fimbrial protein SthE; Provisional; Region: PRK15292 588858014204 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 588858014205 putative fimbrial protein SthD; Provisional; Region: PRK15293 588858014206 putative fimbrial outer membrane usher protein SthC; Provisional; Region: PRK15294 588858014207 PapC N-terminal domain; Region: PapC_N; pfam13954 588858014208 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 588858014209 PapC C-terminal domain; Region: PapC_C; pfam13953 588858014210 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 588858014211 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 588858014212 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 588858014213 putative fimbrial protein SthA; Provisional; Region: PRK15296 588858014214 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 588858014215 Helix-turn-helix domain; Region: HTH_36; pfam13730 588858014216 two-component response regulator; Provisional; Region: PRK11173 588858014217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 588858014218 active site 588858014219 phosphorylation site [posttranslational modification] 588858014220 intermolecular recognition site; other site 588858014221 dimerization interface [polypeptide binding]; other site 588858014222 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 588858014223 DNA binding site [nucleotide binding] 588858014224 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 588858014225 putative RNA methyltransferase; Provisional; Region: PRK10433