-- dump date 20140620_062522 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1249634000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1249634000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1249634000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1249634000004 Walker A motif; other site 1249634000005 ATP binding site [chemical binding]; other site 1249634000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1249634000007 Walker B motif; other site 1249634000008 arginine finger; other site 1249634000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1249634000010 DnaA box-binding interface [nucleotide binding]; other site 1249634000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 1249634000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1249634000013 putative DNA binding surface [nucleotide binding]; other site 1249634000014 dimer interface [polypeptide binding]; other site 1249634000015 beta-clamp/clamp loader binding surface; other site 1249634000016 beta-clamp/translesion DNA polymerase binding surface; other site 1249634000017 recombination protein F; Reviewed; Region: recF; PRK00064 1249634000018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1249634000019 Walker A/P-loop; other site 1249634000020 ATP binding site [chemical binding]; other site 1249634000021 Q-loop/lid; other site 1249634000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1249634000023 ABC transporter signature motif; other site 1249634000024 Walker B; other site 1249634000025 D-loop; other site 1249634000026 H-loop/switch region; other site 1249634000027 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1249634000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1249634000029 Mg2+ binding site [ion binding]; other site 1249634000030 G-X-G motif; other site 1249634000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1249634000032 anchoring element; other site 1249634000033 dimer interface [polypeptide binding]; other site 1249634000034 ATP binding site [chemical binding]; other site 1249634000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1249634000036 active site 1249634000037 putative metal-binding site [ion binding]; other site 1249634000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1249634000039 sugar phosphate phosphatase; Provisional; Region: PRK10513 1249634000040 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1249634000041 active site 1249634000042 motif I; other site 1249634000043 motif II; other site 1249634000044 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1249634000045 motif I; other site 1249634000046 active site 1249634000047 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1249634000048 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1249634000049 ornithine cyclodeaminase; Validated; Region: PRK06823 1249634000050 hypothetical protein; Provisional; Region: PRK06815 1249634000051 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1249634000052 tetramer interface [polypeptide binding]; other site 1249634000053 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634000054 catalytic residue [active] 1249634000055 YheO-like PAS domain; Region: PAS_6; pfam08348 1249634000056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1249634000057 HTH domain; Region: HTH_22; pfam13309 1249634000058 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 1249634000059 hypothetical protein; Provisional; Region: PRK11616 1249634000060 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1249634000061 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1249634000062 putative dimer interface [polypeptide binding]; other site 1249634000063 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1249634000064 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1249634000065 putative dimer interface [polypeptide binding]; other site 1249634000066 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 1249634000067 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1249634000068 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634000069 homodimer interface [polypeptide binding]; other site 1249634000070 catalytic residue [active] 1249634000071 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1249634000072 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1249634000073 dimerization interface [polypeptide binding]; other site 1249634000074 ligand binding site [chemical binding]; other site 1249634000075 NADP binding site [chemical binding]; other site 1249634000076 catalytic site [active] 1249634000077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634000078 D-galactonate transporter; Region: 2A0114; TIGR00893 1249634000079 putative substrate translocation pore; other site 1249634000080 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1249634000081 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1249634000082 substrate binding site [chemical binding]; other site 1249634000083 ATP binding site [chemical binding]; other site 1249634000084 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1249634000085 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1249634000086 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1249634000087 DNA binding site [nucleotide binding] 1249634000088 domain linker motif; other site 1249634000089 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1249634000090 putative dimerization interface [polypeptide binding]; other site 1249634000091 putative ligand binding site [chemical binding]; other site 1249634000092 putative outer membrane lipoprotein; Provisional; Region: PRK10510 1249634000093 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1249634000094 ligand binding site [chemical binding]; other site 1249634000095 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1249634000096 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1249634000097 active site 1249634000098 oxyanion hole [active] 1249634000099 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1249634000100 catalytic triad [active] 1249634000101 Autotransporter beta-domain; Region: Autotransporter; cl17461 1249634000102 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634000103 D-galactonate transporter; Region: 2A0114; TIGR00893 1249634000104 putative substrate translocation pore; other site 1249634000105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634000106 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1249634000107 dimer interface [polypeptide binding]; other site 1249634000108 motif 1; other site 1249634000109 active site 1249634000110 motif 2; other site 1249634000111 motif 3; other site 1249634000112 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1249634000113 DALR anticodon binding domain; Region: DALR_1; pfam05746 1249634000114 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 1249634000115 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 1249634000116 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1249634000117 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1249634000118 active site 1249634000119 P-loop; other site 1249634000120 phosphorylation site [posttranslational modification] 1249634000121 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1249634000122 active site 1249634000123 phosphorylation site [posttranslational modification] 1249634000124 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1249634000125 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1249634000126 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1249634000127 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 1249634000128 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 1249634000129 hypothetical protein; Provisional; Region: PRK11020 1249634000130 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 1249634000131 MOSC domain; Region: MOSC; pfam03473 1249634000132 3-alpha domain; Region: 3-alpha; pfam03475 1249634000133 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1249634000134 dimerization interface [polypeptide binding]; other site 1249634000135 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1249634000136 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1249634000137 dimer interface [polypeptide binding]; other site 1249634000138 putative CheW interface [polypeptide binding]; other site 1249634000139 superoxide dismutase; Provisional; Region: PRK10925 1249634000140 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1249634000141 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1249634000142 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1249634000143 Selenocysteine insertion sequence 3; D781_0035; IMG reference gene:2517281425 1249634000144 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1249634000145 molybdopterin cofactor binding site; other site 1249634000146 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1249634000147 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1249634000148 molybdopterin cofactor binding site; other site 1249634000149 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1249634000150 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1249634000151 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 1249634000152 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1249634000153 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 1249634000154 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1249634000155 hypothetical protein; Provisional; Region: PRK11615 1249634000156 putative glutathione S-transferase; Provisional; Region: PRK10357 1249634000157 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1249634000158 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1249634000159 dimer interface [polypeptide binding]; other site 1249634000160 N-terminal domain interface [polypeptide binding]; other site 1249634000161 putative substrate binding pocket (H-site) [chemical binding]; other site 1249634000162 selenocysteine synthase; Provisional; Region: PRK04311 1249634000163 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 1249634000164 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 1249634000165 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1249634000166 catalytic residue [active] 1249634000167 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 1249634000168 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1249634000169 G1 box; other site 1249634000170 putative GEF interaction site [polypeptide binding]; other site 1249634000171 GTP/Mg2+ binding site [chemical binding]; other site 1249634000172 Switch I region; other site 1249634000173 G2 box; other site 1249634000174 G3 box; other site 1249634000175 Switch II region; other site 1249634000176 G4 box; other site 1249634000177 G5 box; other site 1249634000178 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1249634000179 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 1249634000180 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 1249634000181 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1249634000182 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 1249634000183 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 1249634000184 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1249634000185 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1249634000186 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1249634000187 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 1249634000188 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1249634000189 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1249634000190 putative deaminase; Validated; Region: PRK06846 1249634000191 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1249634000192 active site 1249634000193 PAAR motif; Region: PAAR_motif; pfam05488 1249634000194 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1249634000195 RHS Repeat; Region: RHS_repeat; pfam05593 1249634000196 RHS Repeat; Region: RHS_repeat; pfam05593 1249634000197 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1249634000198 RHS Repeat; Region: RHS_repeat; pfam05593 1249634000199 RHS Repeat; Region: RHS_repeat; cl11982 1249634000200 RHS protein; Region: RHS; pfam03527 1249634000201 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1249634000202 xylulokinase; Provisional; Region: PRK15027 1249634000203 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1249634000204 N- and C-terminal domain interface [polypeptide binding]; other site 1249634000205 active site 1249634000206 MgATP binding site [chemical binding]; other site 1249634000207 catalytic site [active] 1249634000208 metal binding site [ion binding]; metal-binding site 1249634000209 xylulose binding site [chemical binding]; other site 1249634000210 homodimer interface [polypeptide binding]; other site 1249634000211 xylose isomerase; Provisional; Region: PRK05474 1249634000212 xylose isomerase; Region: xylose_isom_A; TIGR02630 1249634000213 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 1249634000214 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1249634000215 putative ligand binding site [chemical binding]; other site 1249634000216 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 1249634000217 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1249634000218 Walker A/P-loop; other site 1249634000219 ATP binding site [chemical binding]; other site 1249634000220 Q-loop/lid; other site 1249634000221 ABC transporter signature motif; other site 1249634000222 Walker B; other site 1249634000223 D-loop; other site 1249634000224 H-loop/switch region; other site 1249634000225 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1249634000226 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1249634000227 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1249634000228 TM-ABC transporter signature motif; other site 1249634000229 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1249634000230 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1249634000231 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1249634000232 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634000233 homodimer interface [polypeptide binding]; other site 1249634000234 catalytic residue [active] 1249634000235 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 1249634000236 putative dimerization interface [polypeptide binding]; other site 1249634000237 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1249634000238 putative ligand binding site [chemical binding]; other site 1249634000239 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634000240 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1249634000241 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634000242 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634000243 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1249634000244 dimerization interface [polypeptide binding]; other site 1249634000245 putative cyanate transporter; Provisional; Region: cynX; PRK09705 1249634000246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634000247 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 1249634000248 Fimbrial protein; Region: Fimbrial; pfam00419 1249634000249 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cl07688 1249634000250 mannosyl binding site [chemical binding]; other site 1249634000251 Fimbrial protein; Region: Fimbrial; pfam00419 1249634000252 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1249634000253 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1249634000254 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 1249634000255 PapC N-terminal domain; Region: PapC_N; pfam13954 1249634000256 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1249634000257 PapC C-terminal domain; Region: PapC_C; pfam13953 1249634000258 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1249634000259 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1249634000260 Fimbrial protein; Region: Fimbrial; cl01416 1249634000261 Fimbrial protein; Region: Fimbrial; cl01416 1249634000262 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1249634000263 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1249634000264 DNA binding residues [nucleotide binding] 1249634000265 dimerization interface [polypeptide binding]; other site 1249634000266 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1249634000267 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1249634000268 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1249634000269 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1249634000270 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1249634000271 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1249634000272 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1249634000273 AP (apurinic/apyrimidinic) site pocket; other site 1249634000274 DNA interaction; other site 1249634000275 D-galactonate transporter; Region: 2A0114; TIGR00893 1249634000276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634000277 putative substrate translocation pore; other site 1249634000278 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1249634000279 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1249634000280 putative NAD(P) binding site [chemical binding]; other site 1249634000281 dimer interface [polypeptide binding]; other site 1249634000282 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634000283 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634000284 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1249634000285 putative effector binding pocket; other site 1249634000286 dimerization interface [polypeptide binding]; other site 1249634000287 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1249634000288 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1249634000289 DNA-binding interface [nucleotide binding]; DNA binding site 1249634000290 IS2 transposase TnpB; Reviewed; Region: PRK09409 1249634000291 HTH-like domain; Region: HTH_21; pfam13276 1249634000292 Integrase core domain; Region: rve; pfam00665 1249634000293 Integrase core domain; Region: rve_3; pfam13683 1249634000294 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1249634000295 B3/4 domain; Region: B3_4; pfam03483 1249634000296 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1249634000297 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1249634000298 non-specific DNA binding site [nucleotide binding]; other site 1249634000299 salt bridge; other site 1249634000300 sequence-specific DNA binding site [nucleotide binding]; other site 1249634000301 Cupin domain; Region: Cupin_2; pfam07883 1249634000302 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1249634000303 catalytic core [active] 1249634000304 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1249634000305 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1249634000306 NAD(P) binding site [chemical binding]; other site 1249634000307 active site 1249634000308 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1249634000309 HD domain; Region: HD_4; pfam13328 1249634000310 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1249634000311 MarR family; Region: MarR; pfam01047 1249634000312 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1249634000313 phosphoethanolamine transferase; Provisional; Region: PRK11560 1249634000314 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1249634000315 Sulfatase; Region: Sulfatase; pfam00884 1249634000316 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 1249634000317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634000318 active site 1249634000319 phosphorylation site [posttranslational modification] 1249634000320 intermolecular recognition site; other site 1249634000321 dimerization interface [polypeptide binding]; other site 1249634000322 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1249634000323 DNA binding residues [nucleotide binding] 1249634000324 dimerization interface [polypeptide binding]; other site 1249634000325 sensory histidine kinase UhpB; Provisional; Region: PRK11644 1249634000326 MASE1; Region: MASE1; cl17823 1249634000327 MASE1; Region: MASE1; cl17823 1249634000328 Histidine kinase; Region: HisKA_3; pfam07730 1249634000329 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1249634000330 ATP binding site [chemical binding]; other site 1249634000331 Mg2+ binding site [ion binding]; other site 1249634000332 G-X-G motif; other site 1249634000333 regulatory protein UhpC; Provisional; Region: PRK11663 1249634000334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634000335 putative substrate translocation pore; other site 1249634000336 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 1249634000337 Caspase domain; Region: Peptidase_C14; pfam00656 1249634000338 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1249634000339 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1249634000340 peptide binding site [polypeptide binding]; other site 1249634000341 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1249634000342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634000343 dimer interface [polypeptide binding]; other site 1249634000344 conserved gate region; other site 1249634000345 putative PBP binding loops; other site 1249634000346 ABC-ATPase subunit interface; other site 1249634000347 dipeptide transporter; Provisional; Region: PRK10913 1249634000348 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1249634000349 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634000350 dimer interface [polypeptide binding]; other site 1249634000351 conserved gate region; other site 1249634000352 putative PBP binding loops; other site 1249634000353 ABC-ATPase subunit interface; other site 1249634000354 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 1249634000355 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1249634000356 Walker A/P-loop; other site 1249634000357 ATP binding site [chemical binding]; other site 1249634000358 Q-loop/lid; other site 1249634000359 ABC transporter signature motif; other site 1249634000360 Walker B; other site 1249634000361 D-loop; other site 1249634000362 H-loop/switch region; other site 1249634000363 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1249634000364 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1249634000365 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1249634000366 Walker A/P-loop; other site 1249634000367 ATP binding site [chemical binding]; other site 1249634000368 Q-loop/lid; other site 1249634000369 ABC transporter signature motif; other site 1249634000370 Walker B; other site 1249634000371 D-loop; other site 1249634000372 H-loop/switch region; other site 1249634000373 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1249634000374 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 1249634000375 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 1249634000376 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 1249634000377 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 1249634000378 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 1249634000379 YhjQ protein; Region: YhjQ; pfam06564 1249634000380 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1249634000381 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 1249634000382 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1249634000383 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1249634000384 DXD motif; other site 1249634000385 PilZ domain; Region: PilZ; pfam07238 1249634000386 cellulose synthase regulator protein; Provisional; Region: PRK11114 1249634000387 endo-1,4-D-glucanase; Provisional; Region: PRK11097 1249634000388 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 1249634000389 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1249634000390 binding surface 1249634000391 TPR motif; other site 1249634000392 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 1249634000393 putative diguanylate cyclase; Provisional; Region: PRK13561 1249634000394 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1249634000395 metal binding site [ion binding]; metal-binding site 1249634000396 active site 1249634000397 I-site; other site 1249634000398 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1249634000399 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1249634000400 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1249634000401 transmembrane helices; other site 1249634000402 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1249634000403 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1249634000404 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1249634000405 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1249634000406 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1249634000407 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1249634000408 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 1249634000409 Part of AAA domain; Region: AAA_19; pfam13245 1249634000410 Family description; Region: UvrD_C_2; pfam13538 1249634000411 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 1249634000412 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1249634000413 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1249634000414 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1249634000415 ATP binding site [chemical binding]; other site 1249634000416 Mg++ binding site [ion binding]; other site 1249634000417 motif III; other site 1249634000418 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1249634000419 nucleotide binding region [chemical binding]; other site 1249634000420 ATP-binding site [chemical binding]; other site 1249634000421 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1249634000422 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1249634000423 catalytic residues [active] 1249634000424 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1249634000425 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1249634000426 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1249634000427 RNA binding site [nucleotide binding]; other site 1249634000428 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1249634000429 multimer interface [polypeptide binding]; other site 1249634000430 Walker A motif; other site 1249634000431 ATP binding site [chemical binding]; other site 1249634000432 Walker B motif; other site 1249634000433 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 1249634000434 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1249634000435 Mg++ binding site [ion binding]; other site 1249634000436 putative catalytic motif [active] 1249634000437 substrate binding site [chemical binding]; other site 1249634000438 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 1249634000439 Chain length determinant protein; Region: Wzz; cl15801 1249634000440 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1249634000441 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1249634000442 active site 1249634000443 homodimer interface [polypeptide binding]; other site 1249634000444 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 1249634000445 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1249634000446 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1249634000447 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1249634000448 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1249634000449 Coenzyme A binding pocket [chemical binding]; other site 1249634000450 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1249634000451 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1249634000452 inhibitor-cofactor binding pocket; inhibition site 1249634000453 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634000454 catalytic residue [active] 1249634000455 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 1249634000456 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 1249634000457 putative common antigen polymerase; Provisional; Region: PRK02975 1249634000458 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1249634000459 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1249634000460 putative transport protein YifK; Provisional; Region: PRK10746 1249634000461 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 1249634000462 HemY protein N-terminus; Region: HemY_N; pfam07219 1249634000463 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1249634000464 TPR motif; other site 1249634000465 binding surface 1249634000466 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1249634000467 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 1249634000468 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1249634000469 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1249634000470 active site 1249634000471 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1249634000472 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1249634000473 domain interfaces; other site 1249634000474 active site 1249634000475 adenylate cyclase; Provisional; Region: cyaA; PRK09450 1249634000476 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 1249634000477 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 1249634000478 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 1249634000479 putative iron binding site [ion binding]; other site 1249634000480 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1249634000481 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1249634000482 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1249634000483 hypothetical protein; Provisional; Region: PRK10963 1249634000484 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 1249634000485 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1249634000486 active site 1249634000487 DNA binding site [nucleotide binding] 1249634000488 Int/Topo IB signature motif; other site 1249634000489 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 1249634000490 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1249634000491 motif II; other site 1249634000492 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1249634000493 Part of AAA domain; Region: AAA_19; pfam13245 1249634000494 Family description; Region: UvrD_C_2; pfam13538 1249634000495 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 1249634000496 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1249634000497 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 1249634000498 Cl binding site [ion binding]; other site 1249634000499 oligomer interface [polypeptide binding]; other site 1249634000500 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 1249634000501 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1249634000502 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1249634000503 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 1249634000504 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1249634000505 CoenzymeA binding site [chemical binding]; other site 1249634000506 subunit interaction site [polypeptide binding]; other site 1249634000507 PHB binding site; other site 1249634000508 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 1249634000509 dimerization interface [polypeptide binding]; other site 1249634000510 substrate binding site [chemical binding]; other site 1249634000511 active site 1249634000512 calcium binding site [ion binding]; other site 1249634000513 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 1249634000514 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1249634000515 ATP binding site [chemical binding]; other site 1249634000516 putative Mg++ binding site [ion binding]; other site 1249634000517 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1249634000518 nucleotide binding region [chemical binding]; other site 1249634000519 ATP-binding site [chemical binding]; other site 1249634000520 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1249634000521 HRDC domain; Region: HRDC; pfam00570 1249634000522 threonine efflux system; Provisional; Region: PRK10229 1249634000523 lysophospholipase L2; Provisional; Region: PRK10749 1249634000524 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1249634000525 putative hydrolase; Provisional; Region: PRK10976 1249634000526 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1249634000527 active site 1249634000528 motif I; other site 1249634000529 motif II; other site 1249634000530 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1249634000531 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 1249634000532 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 1249634000533 active site 1249634000534 catalytic site [active] 1249634000535 metal binding site [ion binding]; metal-binding site 1249634000536 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1249634000537 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634000538 putative substrate translocation pore; other site 1249634000539 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 1249634000540 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1249634000541 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 1249634000542 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1249634000543 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 1249634000544 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1249634000545 Cysteine-rich domain; Region: CCG; pfam02754 1249634000546 Cysteine-rich domain; Region: CCG; pfam02754 1249634000547 hypothetical protein; Provisional; Region: PRK11615 1249634000548 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1249634000549 Coenzyme A binding pocket [chemical binding]; other site 1249634000550 hypothetical protein; Provisional; Region: PRK11212 1249634000551 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 1249634000552 CPxP motif; other site 1249634000553 Protein of unknown function (DUF4056); Region: DUF4056; pfam13265 1249634000554 Surface antigen; Region: Bac_surface_Ag; pfam01103 1249634000555 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 1249634000556 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1249634000557 metal-binding site [ion binding] 1249634000558 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1249634000559 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1249634000560 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 1249634000561 active site 1249634000562 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1249634000563 Protease inhibitor Inh; Region: Inh; pfam02974 1249634000564 Predicted membrane protein [Function unknown]; Region: COG3714 1249634000565 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 1249634000566 hypothetical protein; Provisional; Region: PRK10910 1249634000567 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1249634000568 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1249634000569 S-adenosylmethionine binding site [chemical binding]; other site 1249634000570 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1249634000571 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1249634000572 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1249634000573 P loop; other site 1249634000574 GTP binding site [chemical binding]; other site 1249634000575 cell division protein FtsE; Provisional; Region: PRK10908 1249634000576 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1249634000577 Walker A/P-loop; other site 1249634000578 ATP binding site [chemical binding]; other site 1249634000579 Q-loop/lid; other site 1249634000580 ABC transporter signature motif; other site 1249634000581 Walker B; other site 1249634000582 D-loop; other site 1249634000583 H-loop/switch region; other site 1249634000584 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1249634000585 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 1249634000586 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1249634000587 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1249634000588 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1249634000589 DNA binding residues [nucleotide binding] 1249634000590 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 1249634000591 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 1249634000592 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1249634000593 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1249634000594 dimerization interface [polypeptide binding]; other site 1249634000595 ligand binding site [chemical binding]; other site 1249634000596 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1249634000597 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1249634000598 TM-ABC transporter signature motif; other site 1249634000599 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1249634000600 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1249634000601 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1249634000602 TM-ABC transporter signature motif; other site 1249634000603 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1249634000604 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1249634000605 Walker A/P-loop; other site 1249634000606 ATP binding site [chemical binding]; other site 1249634000607 Q-loop/lid; other site 1249634000608 ABC transporter signature motif; other site 1249634000609 Walker B; other site 1249634000610 D-loop; other site 1249634000611 H-loop/switch region; other site 1249634000612 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 1249634000613 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1249634000614 Walker A/P-loop; other site 1249634000615 ATP binding site [chemical binding]; other site 1249634000616 Q-loop/lid; other site 1249634000617 ABC transporter signature motif; other site 1249634000618 Walker B; other site 1249634000619 D-loop; other site 1249634000620 H-loop/switch region; other site 1249634000621 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1249634000622 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1249634000623 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634000624 homodimer interface [polypeptide binding]; other site 1249634000625 catalytic residue [active] 1249634000626 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 1249634000627 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1249634000628 putative active site [active] 1249634000629 catalytic site [active] 1249634000630 putative metal binding site [ion binding]; other site 1249634000631 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1249634000632 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 1249634000633 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634000634 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 1249634000635 putative dimerization interface [polypeptide binding]; other site 1249634000636 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1249634000637 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1249634000638 THF binding site; other site 1249634000639 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1249634000640 substrate binding site [chemical binding]; other site 1249634000641 THF binding site; other site 1249634000642 zinc-binding site [ion binding]; other site 1249634000643 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1249634000644 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1249634000645 uridine phosphorylase; Provisional; Region: PRK11178 1249634000646 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 1249634000647 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1249634000648 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1249634000649 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1249634000650 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1249634000651 RmuC family; Region: RmuC; pfam02646 1249634000652 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1249634000653 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1249634000654 S-adenosylmethionine binding site [chemical binding]; other site 1249634000655 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1249634000656 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1249634000657 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 1249634000658 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1249634000659 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1249634000660 sec-independent translocase; Provisional; Region: PRK01770 1249634000661 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 1249634000662 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1249634000663 active site 1249634000664 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 1249634000665 dimer interface [polypeptide binding]; other site 1249634000666 allosteric magnesium binding site [ion binding]; other site 1249634000667 active site 1249634000668 aspartate-rich active site metal binding site; other site 1249634000669 Schiff base residues; other site 1249634000670 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 1249634000671 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 1249634000672 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 1249634000673 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1249634000674 active site pocket [active] 1249634000675 oxyanion hole [active] 1249634000676 catalytic triad [active] 1249634000677 active site nucleophile [active] 1249634000678 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 1249634000679 FMN reductase; Validated; Region: fre; PRK08051 1249634000680 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1249634000681 FAD binding pocket [chemical binding]; other site 1249634000682 FAD binding motif [chemical binding]; other site 1249634000683 phosphate binding motif [ion binding]; other site 1249634000684 beta-alpha-beta structure motif; other site 1249634000685 NAD binding pocket [chemical binding]; other site 1249634000686 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1249634000687 Helix-turn-helix domain; Region: HTH_28; pfam13518 1249634000688 putative transposase OrfB; Reviewed; Region: PHA02517 1249634000689 Integrase core domain; Region: rve; pfam00665 1249634000690 Integrase core domain; Region: rve_3; pfam13683 1249634000691 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 1249634000692 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1249634000693 dimer interface [polypeptide binding]; other site 1249634000694 active site 1249634000695 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1249634000696 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1249634000697 substrate binding site [chemical binding]; other site 1249634000698 oxyanion hole (OAH) forming residues; other site 1249634000699 trimer interface [polypeptide binding]; other site 1249634000700 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1249634000701 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1249634000702 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1249634000703 proline dipeptidase; Provisional; Region: PRK13607 1249634000704 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1249634000705 active site 1249634000706 hypothetical protein; Provisional; Region: PRK11568 1249634000707 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1249634000708 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1249634000709 potassium transporter; Provisional; Region: PRK10750 1249634000710 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1249634000711 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 1249634000712 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1249634000713 FAD binding domain; Region: FAD_binding_4; pfam01565 1249634000714 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1249634000715 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1249634000716 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1249634000717 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1249634000718 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1249634000719 pantothenate kinase; Provisional; Region: PRK05439 1249634000720 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1249634000721 ATP-binding site [chemical binding]; other site 1249634000722 CoA-binding site [chemical binding]; other site 1249634000723 Mg2+-binding site [ion binding]; other site 1249634000724 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1249634000725 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1249634000726 Coenzyme A binding pocket [chemical binding]; other site 1249634000727 elongation factor Tu; Reviewed; Region: PRK00049 1249634000728 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1249634000729 G1 box; other site 1249634000730 GEF interaction site [polypeptide binding]; other site 1249634000731 GTP/Mg2+ binding site [chemical binding]; other site 1249634000732 Switch I region; other site 1249634000733 G2 box; other site 1249634000734 G3 box; other site 1249634000735 Switch II region; other site 1249634000736 G4 box; other site 1249634000737 G5 box; other site 1249634000738 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1249634000739 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1249634000740 Antibiotic Binding Site [chemical binding]; other site 1249634000741 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1249634000742 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1249634000743 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1249634000744 putative homodimer interface [polypeptide binding]; other site 1249634000745 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1249634000746 heterodimer interface [polypeptide binding]; other site 1249634000747 homodimer interface [polypeptide binding]; other site 1249634000748 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1249634000749 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1249634000750 23S rRNA interface [nucleotide binding]; other site 1249634000751 L7/L12 interface [polypeptide binding]; other site 1249634000752 putative thiostrepton binding site; other site 1249634000753 L25 interface [polypeptide binding]; other site 1249634000754 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1249634000755 mRNA/rRNA interface [nucleotide binding]; other site 1249634000756 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1249634000757 23S rRNA interface [nucleotide binding]; other site 1249634000758 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1249634000759 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1249634000760 core dimer interface [polypeptide binding]; other site 1249634000761 peripheral dimer interface [polypeptide binding]; other site 1249634000762 L10 interface [polypeptide binding]; other site 1249634000763 L11 interface [polypeptide binding]; other site 1249634000764 putative EF-Tu interaction site [polypeptide binding]; other site 1249634000765 putative EF-G interaction site [polypeptide binding]; other site 1249634000766 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1249634000767 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1249634000768 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1249634000769 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1249634000770 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1249634000771 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1249634000772 RPB3 interaction site [polypeptide binding]; other site 1249634000773 RPB1 interaction site [polypeptide binding]; other site 1249634000774 RPB11 interaction site [polypeptide binding]; other site 1249634000775 RPB10 interaction site [polypeptide binding]; other site 1249634000776 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1249634000777 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1249634000778 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1249634000779 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1249634000780 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1249634000781 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1249634000782 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1249634000783 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1249634000784 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1249634000785 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1249634000786 DNA binding site [nucleotide binding] 1249634000787 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1249634000788 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 1249634000789 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1249634000790 FeS/SAM binding site; other site 1249634000791 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1249634000792 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1249634000793 ThiS interaction site; other site 1249634000794 putative active site [active] 1249634000795 tetramer interface [polypeptide binding]; other site 1249634000796 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1249634000797 thiS-thiF/thiG interaction site; other site 1249634000798 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1249634000799 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1249634000800 ATP binding site [chemical binding]; other site 1249634000801 substrate interface [chemical binding]; other site 1249634000802 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1249634000803 thiamine phosphate binding site [chemical binding]; other site 1249634000804 active site 1249634000805 pyrophosphate binding site [ion binding]; other site 1249634000806 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1249634000807 ThiC-associated domain; Region: ThiC-associated; pfam13667 1249634000808 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1249634000809 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 1249634000810 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1249634000811 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1249634000812 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1249634000813 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1249634000814 putative NADH binding site [chemical binding]; other site 1249634000815 putative active site [active] 1249634000816 nudix motif; other site 1249634000817 putative metal binding site [ion binding]; other site 1249634000818 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1249634000819 substrate binding site [chemical binding]; other site 1249634000820 active site 1249634000821 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1249634000822 Active_site [active] 1249634000823 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 1249634000824 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1249634000825 IHF dimer interface [polypeptide binding]; other site 1249634000826 IHF - DNA interface [nucleotide binding]; other site 1249634000827 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 1249634000828 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1249634000829 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1249634000830 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1249634000831 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1249634000832 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1249634000833 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1249634000834 purine monophosphate binding site [chemical binding]; other site 1249634000835 dimer interface [polypeptide binding]; other site 1249634000836 putative catalytic residues [active] 1249634000837 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1249634000838 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1249634000839 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1249634000840 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1249634000841 Na binding site [ion binding]; other site 1249634000842 Predicted membrane protein [Function unknown]; Region: COG3162 1249634000843 acetyl-CoA synthetase; Provisional; Region: PRK00174 1249634000844 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1249634000845 active site 1249634000846 CoA binding site [chemical binding]; other site 1249634000847 acyl-activating enzyme (AAE) consensus motif; other site 1249634000848 AMP binding site [chemical binding]; other site 1249634000849 acetate binding site [chemical binding]; other site 1249634000850 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 1249634000851 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1249634000852 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1249634000853 active site clefts [active] 1249634000854 zinc binding site [ion binding]; other site 1249634000855 dimer interface [polypeptide binding]; other site 1249634000856 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1249634000857 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1249634000858 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1249634000859 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1249634000860 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1249634000861 putative acyl-acceptor binding pocket; other site 1249634000862 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 1249634000863 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1249634000864 HlyD family secretion protein; Region: HlyD_3; pfam13437 1249634000865 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1249634000866 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1249634000867 Walker A/P-loop; other site 1249634000868 ATP binding site [chemical binding]; other site 1249634000869 Q-loop/lid; other site 1249634000870 ABC transporter signature motif; other site 1249634000871 Walker B; other site 1249634000872 D-loop; other site 1249634000873 H-loop/switch region; other site 1249634000874 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1249634000875 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1249634000876 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1249634000877 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1249634000878 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 1249634000879 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1249634000880 inhibitor-cofactor binding pocket; inhibition site 1249634000881 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634000882 catalytic residue [active] 1249634000883 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1249634000884 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1249634000885 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1249634000886 argininosuccinate lyase; Provisional; Region: PRK02186 1249634000887 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1249634000888 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1249634000889 tetramer interface [polypeptide binding]; other site 1249634000890 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1249634000891 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634000892 catalytic residue [active] 1249634000893 dimer interface [polypeptide binding]; other site 1249634000894 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634000895 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1249634000896 putative substrate translocation pore; other site 1249634000897 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1249634000898 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1249634000899 acyl-activating enzyme (AAE) consensus motif; other site 1249634000900 AMP binding site [chemical binding]; other site 1249634000901 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1249634000902 Condensation domain; Region: Condensation; pfam00668 1249634000903 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1249634000904 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1249634000905 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1249634000906 acyl-activating enzyme (AAE) consensus motif; other site 1249634000907 AMP binding site [chemical binding]; other site 1249634000908 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1249634000909 Condensation domain; Region: Condensation; pfam00668 1249634000910 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1249634000911 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1249634000912 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1249634000913 acyl-activating enzyme (AAE) consensus motif; other site 1249634000914 AMP binding site [chemical binding]; other site 1249634000915 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1249634000916 Condensation domain; Region: Condensation; pfam00668 1249634000917 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1249634000918 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1249634000919 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1249634000920 acyl-activating enzyme (AAE) consensus motif; other site 1249634000921 AMP binding site [chemical binding]; other site 1249634000922 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1249634000923 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1249634000924 MbtH-like protein; Region: MbtH; cl01279 1249634000925 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 1249634000926 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1249634000927 putative transcriptional regulator; Provisional; Region: PRK11640 1249634000928 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1249634000929 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1249634000930 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1249634000931 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1249634000932 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1249634000933 DsbD alpha interface [polypeptide binding]; other site 1249634000934 catalytic residues [active] 1249634000935 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 1249634000936 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1249634000937 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1249634000938 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1249634000939 Aspartase; Region: Aspartase; cd01357 1249634000940 active sites [active] 1249634000941 tetramer interface [polypeptide binding]; other site 1249634000942 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 1249634000943 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1249634000944 oligomerisation interface [polypeptide binding]; other site 1249634000945 mobile loop; other site 1249634000946 roof hairpin; other site 1249634000947 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1249634000948 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1249634000949 ring oligomerisation interface [polypeptide binding]; other site 1249634000950 ATP/Mg binding site [chemical binding]; other site 1249634000951 stacking interactions; other site 1249634000952 hinge regions; other site 1249634000953 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1249634000954 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1249634000955 active site 1249634000956 TDP-binding site; other site 1249634000957 acceptor substrate-binding pocket; other site 1249634000958 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 1249634000959 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1249634000960 Helix-turn-helix domain; Region: HTH_28; pfam13518 1249634000961 putative transposase OrfB; Reviewed; Region: PHA02517 1249634000962 Integrase core domain; Region: rve; pfam00665 1249634000963 Integrase core domain; Region: rve_3; pfam13683 1249634000964 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1249634000965 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1249634000966 FeS/SAM binding site; other site 1249634000967 elongation factor P; Validated; Region: PRK00529 1249634000968 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1249634000969 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1249634000970 RNA binding site [nucleotide binding]; other site 1249634000971 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1249634000972 RNA binding site [nucleotide binding]; other site 1249634000973 Predicted small secreted protein [Function unknown]; Region: COG5510 1249634000974 multidrug efflux system protein; Provisional; Region: PRK11431 1249634000975 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 1249634000976 Iron-sulfur protein interface; other site 1249634000977 proximal quinone binding site [chemical binding]; other site 1249634000978 C-subunit interface; other site 1249634000979 distal quinone binding site; other site 1249634000980 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 1249634000981 D-subunit interface [polypeptide binding]; other site 1249634000982 Iron-sulfur protein interface; other site 1249634000983 proximal quinone binding site [chemical binding]; other site 1249634000984 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 1249634000985 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1249634000986 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 1249634000987 L-aspartate oxidase; Provisional; Region: PRK06175 1249634000988 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1249634000989 poxB regulator PoxA; Provisional; Region: PRK09350 1249634000990 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1249634000991 motif 1; other site 1249634000992 dimer interface [polypeptide binding]; other site 1249634000993 active site 1249634000994 motif 2; other site 1249634000995 motif 3; other site 1249634000996 putative mechanosensitive channel protein; Provisional; Region: PRK10929 1249634000997 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1249634000998 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1249634000999 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1249634001000 GTPase RsgA; Reviewed; Region: PRK12288 1249634001001 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1249634001002 RNA binding site [nucleotide binding]; other site 1249634001003 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1249634001004 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1249634001005 GTP/Mg2+ binding site [chemical binding]; other site 1249634001006 G4 box; other site 1249634001007 G5 box; other site 1249634001008 G1 box; other site 1249634001009 Switch I region; other site 1249634001010 G2 box; other site 1249634001011 G3 box; other site 1249634001012 Switch II region; other site 1249634001013 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1249634001014 catalytic site [active] 1249634001015 putative active site [active] 1249634001016 putative substrate binding site [chemical binding]; other site 1249634001017 dimer interface [polypeptide binding]; other site 1249634001018 epoxyqueuosine reductase; Region: TIGR00276 1249634001019 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1249634001020 putative carbohydrate kinase; Provisional; Region: PRK10565 1249634001021 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1249634001022 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1249634001023 putative substrate binding site [chemical binding]; other site 1249634001024 putative ATP binding site [chemical binding]; other site 1249634001025 ADP-binding protein; Provisional; Region: PRK10646 1249634001026 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 1249634001027 AMIN domain; Region: AMIN; pfam11741 1249634001028 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1249634001029 active site 1249634001030 metal binding site [ion binding]; metal-binding site 1249634001031 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1249634001032 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1249634001033 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1249634001034 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1249634001035 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1249634001036 ATP binding site [chemical binding]; other site 1249634001037 Mg2+ binding site [ion binding]; other site 1249634001038 G-X-G motif; other site 1249634001039 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1249634001040 ATP binding site [chemical binding]; other site 1249634001041 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1249634001042 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1249634001043 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1249634001044 bacterial Hfq-like; Region: Hfq; cd01716 1249634001045 hexamer interface [polypeptide binding]; other site 1249634001046 Sm1 motif; other site 1249634001047 RNA binding site [nucleotide binding]; other site 1249634001048 Sm2 motif; other site 1249634001049 GTPase HflX; Provisional; Region: PRK11058 1249634001050 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1249634001051 HflX GTPase family; Region: HflX; cd01878 1249634001052 G1 box; other site 1249634001053 GTP/Mg2+ binding site [chemical binding]; other site 1249634001054 Switch I region; other site 1249634001055 G2 box; other site 1249634001056 G3 box; other site 1249634001057 Switch II region; other site 1249634001058 G4 box; other site 1249634001059 G5 box; other site 1249634001060 FtsH protease regulator HflK; Provisional; Region: PRK10930 1249634001061 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 1249634001062 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1249634001063 FtsH protease regulator HflC; Provisional; Region: PRK11029 1249634001064 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1249634001065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 1249634001066 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1249634001067 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1249634001068 GDP-binding site [chemical binding]; other site 1249634001069 ACT binding site; other site 1249634001070 IMP binding site; other site 1249634001071 transcriptional repressor NsrR; Provisional; Region: PRK11014 1249634001072 Rrf2 family protein; Region: rrf2_super; TIGR00738 1249634001073 exoribonuclease R; Provisional; Region: PRK11642 1249634001074 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 1249634001075 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1249634001076 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1249634001077 RNB domain; Region: RNB; pfam00773 1249634001078 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1249634001079 RNA binding site [nucleotide binding]; other site 1249634001080 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1249634001081 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1249634001082 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1249634001083 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1249634001084 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1249634001085 active site 1249634001086 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1249634001087 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1249634001088 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 1249634001089 esterase; Provisional; Region: PRK10566 1249634001090 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1249634001091 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1249634001092 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1249634001093 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1249634001094 dimer interface [polypeptide binding]; other site 1249634001095 ssDNA binding site [nucleotide binding]; other site 1249634001096 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1249634001097 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1249634001098 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1249634001099 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1249634001100 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1249634001101 Protein of unknown function, DUF488; Region: DUF488; cl01246 1249634001102 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 1249634001103 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 1249634001104 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 1249634001105 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1249634001106 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1249634001107 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 1249634001108 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1249634001109 active site 1249634001110 metal binding site [ion binding]; metal-binding site 1249634001111 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1249634001112 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1249634001113 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1249634001114 active site 1249634001115 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; cl17398 1249634001116 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 1249634001117 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1249634001118 Domain of unknown function DUF21; Region: DUF21; pfam01595 1249634001119 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1249634001120 Transporter associated domain; Region: CorC_HlyC; smart01091 1249634001121 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1249634001122 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1249634001123 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1249634001124 Surface antigen; Region: Bac_surface_Ag; pfam01103 1249634001125 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1249634001126 Family of unknown function (DUF490); Region: DUF490; pfam04357 1249634001127 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1249634001128 putative active site pocket [active] 1249634001129 dimerization interface [polypeptide binding]; other site 1249634001130 putative catalytic residue [active] 1249634001131 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1249634001132 dimer interface [polypeptide binding]; other site 1249634001133 substrate binding site [chemical binding]; other site 1249634001134 metal binding sites [ion binding]; metal-binding site 1249634001135 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1249634001136 dimer interface [polypeptide binding]; other site 1249634001137 ligand binding site [chemical binding]; other site 1249634001138 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1249634001139 dimerization interface [polypeptide binding]; other site 1249634001140 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1249634001141 dimer interface [polypeptide binding]; other site 1249634001142 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1249634001143 putative CheW interface [polypeptide binding]; other site 1249634001144 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1249634001145 AMP binding site [chemical binding]; other site 1249634001146 metal binding site [ion binding]; metal-binding site 1249634001147 active site 1249634001148 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1249634001149 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1249634001150 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1249634001151 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1249634001152 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1249634001153 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1249634001154 arginine repressor; Provisional; Region: PRK05066 1249634001155 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1249634001156 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1249634001157 malate dehydrogenase; Provisional; Region: PRK05086 1249634001158 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 1249634001159 NAD binding site [chemical binding]; other site 1249634001160 dimerization interface [polypeptide binding]; other site 1249634001161 Substrate binding site [chemical binding]; other site 1249634001162 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 1249634001163 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 1249634001164 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 1249634001165 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1249634001166 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1249634001167 substrate binding pocket [chemical binding]; other site 1249634001168 chain length determination region; other site 1249634001169 substrate-Mg2+ binding site; other site 1249634001170 catalytic residues [active] 1249634001171 aspartate-rich region 1; other site 1249634001172 active site lid residues [active] 1249634001173 aspartate-rich region 2; other site 1249634001174 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1249634001175 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1249634001176 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1249634001177 EamA-like transporter family; Region: EamA; pfam00892 1249634001178 GTPase CgtA; Reviewed; Region: obgE; PRK12298 1249634001179 GTP1/OBG; Region: GTP1_OBG; pfam01018 1249634001180 Obg GTPase; Region: Obg; cd01898 1249634001181 G1 box; other site 1249634001182 GTP/Mg2+ binding site [chemical binding]; other site 1249634001183 Switch I region; other site 1249634001184 G2 box; other site 1249634001185 G3 box; other site 1249634001186 Switch II region; other site 1249634001187 G4 box; other site 1249634001188 G5 box; other site 1249634001189 sensor protein BasS/PmrB; Provisional; Region: PRK10755 1249634001190 HAMP domain; Region: HAMP; pfam00672 1249634001191 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1249634001192 dimer interface [polypeptide binding]; other site 1249634001193 phosphorylation site [posttranslational modification] 1249634001194 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1249634001195 ATP binding site [chemical binding]; other site 1249634001196 Mg2+ binding site [ion binding]; other site 1249634001197 G-X-G motif; other site 1249634001198 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1249634001199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634001200 active site 1249634001201 phosphorylation site [posttranslational modification] 1249634001202 intermolecular recognition site; other site 1249634001203 dimerization interface [polypeptide binding]; other site 1249634001204 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1249634001205 DNA binding site [nucleotide binding] 1249634001206 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 1249634001207 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1249634001208 Enterobacteria greA leader; D781_0383; IMG reference gene:2517281773 1249634001209 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1249634001210 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1249634001211 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1249634001212 RNA-binding protein YhbY; Provisional; Region: PRK10343 1249634001213 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1249634001214 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1249634001215 S-adenosylmethionine binding site [chemical binding]; other site 1249634001216 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 1249634001217 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1249634001218 Walker A motif; other site 1249634001219 ATP binding site [chemical binding]; other site 1249634001220 Walker B motif; other site 1249634001221 arginine finger; other site 1249634001222 Peptidase family M41; Region: Peptidase_M41; pfam01434 1249634001223 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1249634001224 dihydropteroate synthase; Region: DHPS; TIGR01496 1249634001225 substrate binding pocket [chemical binding]; other site 1249634001226 dimer interface [polypeptide binding]; other site 1249634001227 inhibitor binding site; inhibition site 1249634001228 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1249634001229 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1249634001230 active site 1249634001231 substrate binding site [chemical binding]; other site 1249634001232 metal binding site [ion binding]; metal-binding site 1249634001233 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1249634001234 Enterobacteria rnk leader; D781_0393; IMG reference gene:2517281783 1249634001235 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1249634001236 hypothetical protein; Provisional; Region: PRK14641 1249634001237 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1249634001238 putative oligomer interface [polypeptide binding]; other site 1249634001239 putative RNA binding site [nucleotide binding]; other site 1249634001240 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1249634001241 NusA N-terminal domain; Region: NusA_N; pfam08529 1249634001242 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1249634001243 RNA binding site [nucleotide binding]; other site 1249634001244 homodimer interface [polypeptide binding]; other site 1249634001245 NusA-like KH domain; Region: KH_5; pfam13184 1249634001246 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1249634001247 G-X-X-G motif; other site 1249634001248 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1249634001249 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1249634001250 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1249634001251 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1249634001252 translation initiation factor IF-2; Region: IF-2; TIGR00487 1249634001253 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1249634001254 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1249634001255 G1 box; other site 1249634001256 putative GEF interaction site [polypeptide binding]; other site 1249634001257 GTP/Mg2+ binding site [chemical binding]; other site 1249634001258 Switch I region; other site 1249634001259 G2 box; other site 1249634001260 G3 box; other site 1249634001261 Switch II region; other site 1249634001262 G4 box; other site 1249634001263 G5 box; other site 1249634001264 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1249634001265 Translation-initiation factor 2; Region: IF-2; pfam11987 1249634001266 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1249634001267 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1249634001268 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1249634001269 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1249634001270 RNA binding site [nucleotide binding]; other site 1249634001271 active site 1249634001272 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1249634001273 Ribosomal S15 leader; D781_0399; IMG reference gene:2517281789 1249634001274 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1249634001275 16S/18S rRNA binding site [nucleotide binding]; other site 1249634001276 S13e-L30e interaction site [polypeptide binding]; other site 1249634001277 25S rRNA binding site [nucleotide binding]; other site 1249634001278 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1249634001279 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1249634001280 RNase E interface [polypeptide binding]; other site 1249634001281 trimer interface [polypeptide binding]; other site 1249634001282 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1249634001283 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1249634001284 RNase E interface [polypeptide binding]; other site 1249634001285 trimer interface [polypeptide binding]; other site 1249634001286 active site 1249634001287 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1249634001288 putative nucleic acid binding region [nucleotide binding]; other site 1249634001289 G-X-X-G motif; other site 1249634001290 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1249634001291 RNA binding site [nucleotide binding]; other site 1249634001292 domain interface; other site 1249634001293 lipoprotein NlpI; Provisional; Region: PRK11189 1249634001294 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1249634001295 binding surface 1249634001296 TPR motif; other site 1249634001297 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 1249634001298 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1249634001299 ATP binding site [chemical binding]; other site 1249634001300 Mg++ binding site [ion binding]; other site 1249634001301 motif III; other site 1249634001302 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1249634001303 nucleotide binding region [chemical binding]; other site 1249634001304 ATP-binding site [chemical binding]; other site 1249634001305 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1249634001306 putative RNA binding site [nucleotide binding]; other site 1249634001307 putative inner membrane protein; Provisional; Region: PRK11099 1249634001308 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 1249634001309 CPxP motif; other site 1249634001310 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1249634001311 salt bridge; other site 1249634001312 non-specific DNA binding site [nucleotide binding]; other site 1249634001313 sequence-specific DNA binding site [nucleotide binding]; other site 1249634001314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634001315 putative substrate translocation pore; other site 1249634001316 hypothetical protein; Provisional; Region: PRK10508 1249634001317 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1249634001318 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1249634001319 HlyD family secretion protein; Region: HlyD_3; pfam13437 1249634001320 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1249634001321 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1249634001322 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1249634001323 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1249634001324 putative protease; Provisional; Region: PRK15447 1249634001325 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1249634001326 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1249634001327 Peptidase family U32; Region: Peptidase_U32; pfam01136 1249634001328 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 1249634001329 Predicted acetyltransferase [General function prediction only]; Region: COG3153 1249634001330 Coenzyme A binding pocket [chemical binding]; other site 1249634001331 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1249634001332 GIY-YIG motif/motif A; other site 1249634001333 putative active site [active] 1249634001334 putative metal binding site [ion binding]; other site 1249634001335 CRISPR-associated endonuclease Cas1, subtype I-F/YPEST; Region: cas1_YPEST; TIGR03637 1249634001336 CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673 1249634001337 CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562 1249634001338 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cd09735 1249634001339 CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09736 1249634001340 CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737 1249634001341 CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739 1249634001342 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1249634001343 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1249634001344 putative DNA binding site [nucleotide binding]; other site 1249634001345 putative Zn2+ binding site [ion binding]; other site 1249634001346 AsnC family; Region: AsnC_trans_reg; pfam01037 1249634001347 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1249634001348 hypothetical protein; Provisional; Region: PRK03467 1249634001349 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 1249634001350 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1249634001351 NAD binding site [chemical binding]; other site 1249634001352 active site 1249634001353 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 1249634001354 putative hydrolase; Provisional; Region: PRK02113 1249634001355 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1249634001356 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 1249634001357 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1249634001358 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 1249634001359 active site 1249634001360 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 1249634001361 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1249634001362 Walker A/P-loop; other site 1249634001363 ATP binding site [chemical binding]; other site 1249634001364 Q-loop/lid; other site 1249634001365 ABC transporter signature motif; other site 1249634001366 Walker B; other site 1249634001367 D-loop; other site 1249634001368 H-loop/switch region; other site 1249634001369 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 1249634001370 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1249634001371 Walker A/P-loop; other site 1249634001372 ATP binding site [chemical binding]; other site 1249634001373 Q-loop/lid; other site 1249634001374 ABC transporter signature motif; other site 1249634001375 Walker B; other site 1249634001376 D-loop; other site 1249634001377 H-loop/switch region; other site 1249634001378 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1249634001379 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 1249634001380 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 1249634001381 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 1249634001382 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 1249634001383 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 1249634001384 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1249634001385 DNA-binding site [nucleotide binding]; DNA binding site 1249634001386 UTRA domain; Region: UTRA; pfam07702 1249634001387 Predicted permease; Region: DUF318; cl17795 1249634001388 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1249634001389 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 1249634001390 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1249634001391 FeS/SAM binding site; other site 1249634001392 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1249634001393 ATP cone domain; Region: ATP-cone; pfam03477 1249634001394 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1249634001395 effector binding site; other site 1249634001396 active site 1249634001397 Zn binding site [ion binding]; other site 1249634001398 glycine loop; other site 1249634001399 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 1249634001400 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1249634001401 Ca binding site [ion binding]; other site 1249634001402 active site 1249634001403 catalytic site [active] 1249634001404 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1249634001405 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 1249634001406 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1249634001407 active site turn [active] 1249634001408 phosphorylation site [posttranslational modification] 1249634001409 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1249634001410 trehalose repressor; Provisional; Region: treR; PRK09492 1249634001411 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1249634001412 DNA binding site [nucleotide binding] 1249634001413 domain linker motif; other site 1249634001414 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 1249634001415 dimerization interface [polypeptide binding]; other site 1249634001416 ligand binding site [chemical binding]; other site 1249634001417 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1249634001418 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1249634001419 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1249634001420 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1249634001421 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 1249634001422 putative active site [active] 1249634001423 metal binding site [ion binding]; metal-binding site 1249634001424 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1249634001425 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1249634001426 inhibitor site; inhibition site 1249634001427 active site 1249634001428 dimer interface [polypeptide binding]; other site 1249634001429 catalytic residue [active] 1249634001430 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1249634001431 Na binding site [ion binding]; other site 1249634001432 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 1249634001433 BNR repeat-like domain; Region: BNR_2; pfam13088 1249634001434 Domain of unknown function (DUF386); Region: DUF386; cl01047 1249634001435 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1249634001436 classical (c) SDRs; Region: SDR_c; cd05233 1249634001437 NAD(P) binding site [chemical binding]; other site 1249634001438 active site 1249634001439 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 1249634001440 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 1249634001441 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1249634001442 active site 1249634001443 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 1249634001444 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1249634001445 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1249634001446 acyl-activating enzyme (AAE) consensus motif; other site 1249634001447 AMP binding site [chemical binding]; other site 1249634001448 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1249634001449 thioester reductase domain; Region: Thioester-redct; TIGR01746 1249634001450 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1249634001451 NAD(P) binding site [chemical binding]; other site 1249634001452 active site 1249634001453 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1249634001454 homotrimer interaction site [polypeptide binding]; other site 1249634001455 putative active site [active] 1249634001456 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 1249634001457 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 1249634001458 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 1249634001459 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 1249634001460 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1249634001461 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1249634001462 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 1249634001463 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1249634001464 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1249634001465 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 1249634001466 RNase E inhibitor protein; Provisional; Region: PRK11191 1249634001467 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 1249634001468 active site 1249634001469 dinuclear metal binding site [ion binding]; other site 1249634001470 dimerization interface [polypeptide binding]; other site 1249634001471 choline dehydrogenase; Validated; Region: PRK02106 1249634001472 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1249634001473 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1249634001474 Coenzyme A binding pocket [chemical binding]; other site 1249634001475 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1249634001476 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1249634001477 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1249634001478 HIGH motif; other site 1249634001479 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1249634001480 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1249634001481 active site 1249634001482 KMSKS motif; other site 1249634001483 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1249634001484 tRNA binding surface [nucleotide binding]; other site 1249634001485 anticodon binding site; other site 1249634001486 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1249634001487 DNA polymerase III subunit chi; Validated; Region: PRK05728 1249634001488 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1249634001489 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1249634001490 interface (dimer of trimers) [polypeptide binding]; other site 1249634001491 Substrate-binding/catalytic site; other site 1249634001492 Zn-binding sites [ion binding]; other site 1249634001493 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 1249634001494 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1249634001495 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 1249634001496 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1249634001497 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1249634001498 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1249634001499 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 1249634001500 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1249634001501 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1249634001502 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1249634001503 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1249634001504 Hexamer interface [polypeptide binding]; other site 1249634001505 Hexagonal pore residue; other site 1249634001506 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 1249634001507 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1249634001508 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1249634001509 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 1249634001510 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1249634001511 dimer interface [polypeptide binding]; other site 1249634001512 active site 1249634001513 glycine loop; other site 1249634001514 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1249634001515 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 1249634001516 putative active site [active] 1249634001517 metal binding site [ion binding]; metal-binding site 1249634001518 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1249634001519 Hexamer/Pentamer interface [polypeptide binding]; other site 1249634001520 central pore; other site 1249634001521 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1249634001522 putative catalytic cysteine [active] 1249634001523 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1249634001524 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1249634001525 Hexamer interface [polypeptide binding]; other site 1249634001526 Hexagonal pore residue; other site 1249634001527 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1249634001528 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1249634001529 Hexamer interface [polypeptide binding]; other site 1249634001530 Hexagonal pore residue; other site 1249634001531 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1249634001532 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1249634001533 Hexamer interface [polypeptide binding]; other site 1249634001534 Hexagonal pore residue; other site 1249634001535 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1249634001536 DNA binding site [nucleotide binding] 1249634001537 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1249634001538 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1249634001539 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 1249634001540 putative NAD(P) binding site [chemical binding]; other site 1249634001541 active site 1249634001542 putative substrate binding site [chemical binding]; other site 1249634001543 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1249634001544 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1249634001545 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1249634001546 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1249634001547 DNA phosphorothioation-dependent restriction protein DptF; Region: dnd_assoc_3; TIGR03238 1249634001548 DNA phosphorothioation-dependent restriction protein DptG; Region: dnd_assoc_1; TIGR03236 1249634001549 DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237 1249634001550 AAA-like domain; Region: AAA_10; pfam12846 1249634001551 Protein of unknown function DUF262; Region: DUF262; pfam03235 1249634001552 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1249634001553 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1249634001554 Domain of unknown function (DUF1832); Region: DUF1832; pfam08870 1249634001555 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 1249634001556 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1249634001557 Walker A/P-loop; other site 1249634001558 ATP binding site [chemical binding]; other site 1249634001559 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1249634001560 ABC transporter signature motif; other site 1249634001561 Walker B; other site 1249634001562 D-loop; other site 1249634001563 H-loop/switch region; other site 1249634001564 hypothetical protein; Provisional; Region: PRK06850 1249634001565 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1249634001566 Active Sites [active] 1249634001567 DNA-sulfur modification-associated; Region: DndB; pfam14072 1249634001568 DGQHR domain; Region: DGQHR; TIGR03187 1249634001569 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1249634001570 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1249634001571 inhibitor-cofactor binding pocket; inhibition site 1249634001572 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634001573 catalytic residue [active] 1249634001574 ethanolamine permease; Region: 2A0305; TIGR00908 1249634001575 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1249634001576 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1249634001577 active site 1249634001578 substrate binding site [chemical binding]; other site 1249634001579 ATP binding site [chemical binding]; other site 1249634001580 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1249634001581 SurA N-terminal domain; Region: SurA_N; pfam09312 1249634001582 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1249634001583 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634001584 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1249634001585 beta-galactosidase; Region: BGL; TIGR03356 1249634001586 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 1249634001587 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1249634001588 active site turn [active] 1249634001589 phosphorylation site [posttranslational modification] 1249634001590 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1249634001591 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1249634001592 HPr interaction site; other site 1249634001593 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1249634001594 active site 1249634001595 phosphorylation site [posttranslational modification] 1249634001596 Survival protein SurE; Region: SurE; pfam01975 1249634001597 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1249634001598 catalytic core [active] 1249634001599 outer membrane porin, OprD family; Region: OprD; pfam03573 1249634001600 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1249634001601 CAT RNA binding domain; Region: CAT_RBD; smart01061 1249634001602 PRD domain; Region: PRD; pfam00874 1249634001603 PRD domain; Region: PRD; pfam00874 1249634001604 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 1249634001605 Phosphotransferase enzyme family; Region: APH; pfam01636 1249634001606 active site 1249634001607 ATP binding site [chemical binding]; other site 1249634001608 antibiotic binding site [chemical binding]; other site 1249634001609 HNH endonuclease; Region: HNH_2; pfam13391 1249634001610 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 1249634001611 PAAR motif; Region: PAAR_motif; pfam05488 1249634001612 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1249634001613 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1249634001614 RHS Repeat; Region: RHS_repeat; pfam05593 1249634001615 RHS Repeat; Region: RHS_repeat; pfam05593 1249634001616 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1249634001617 RHS Repeat; Region: RHS_repeat; cl11982 1249634001618 RHS protein; Region: RHS; pfam03527 1249634001619 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1249634001620 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1249634001621 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 1249634001622 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1249634001623 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1249634001624 Na binding site [ion binding]; other site 1249634001625 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1249634001626 homotrimer interaction site [polypeptide binding]; other site 1249634001627 putative active site [active] 1249634001628 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 1249634001629 acetylornithine deacetylase; Provisional; Region: PRK07522 1249634001630 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1249634001631 metal binding site [ion binding]; metal-binding site 1249634001632 putative dimer interface [polypeptide binding]; other site 1249634001633 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634001634 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634001635 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 1249634001636 putative substrate binding pocket [chemical binding]; other site 1249634001637 dimerization interface [polypeptide binding]; other site 1249634001638 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1249634001639 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1249634001640 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1249634001641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634001642 putative substrate translocation pore; other site 1249634001643 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1249634001644 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1249634001645 peptide binding site [polypeptide binding]; other site 1249634001646 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 1249634001647 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1249634001648 P-loop, Walker A motif; other site 1249634001649 Base recognition motif; other site 1249634001650 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1249634001651 Uncharacterized small protein [Function unknown]; Region: COG2879 1249634001652 carbon starvation protein A; Provisional; Region: PRK15015 1249634001653 Carbon starvation protein CstA; Region: CstA; pfam02554 1249634001654 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1249634001655 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1249634001656 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1249634001657 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1249634001658 PQQ-like domain; Region: PQQ_2; pfam13360 1249634001659 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1249634001660 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1249634001661 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1249634001662 trimer interface [polypeptide binding]; other site 1249634001663 eyelet of channel; other site 1249634001664 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1249634001665 Helix-turn-helix domain; Region: HTH_18; pfam12833 1249634001666 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634001667 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 1249634001668 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1249634001669 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1249634001670 L,D-transpeptidase; Provisional; Region: PRK10260 1249634001671 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 1249634001672 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1249634001673 Putative catalytic domain, repeat 1, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_1; cd09106 1249634001674 PLD-like domain; Region: PLDc_2; pfam13091 1249634001675 putative active site [active] 1249634001676 putative catalytic site [active] 1249634001677 Putative catalytic domain, repeat 2, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_2; cd09107 1249634001678 PLD-like domain; Region: PLDc_2; pfam13091 1249634001679 putative active site [active] 1249634001680 putative catalytic site [active] 1249634001681 Protein of unknown function (DUF1043); Region: DUF1043; cl11473 1249634001682 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1249634001683 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1249634001684 active site 1249634001685 NAD binding site [chemical binding]; other site 1249634001686 metal binding site [ion binding]; metal-binding site 1249634001687 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1249634001688 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1249634001689 DNA binding residues [nucleotide binding] 1249634001690 dimerization interface [polypeptide binding]; other site 1249634001691 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1249634001692 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1249634001693 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 1249634001694 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1249634001695 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1249634001696 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 1249634001697 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1249634001698 active site 1249634001699 Zn binding site [ion binding]; other site 1249634001700 benzoate transport; Region: 2A0115; TIGR00895 1249634001701 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1249634001702 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1249634001703 DNA binding residues [nucleotide binding] 1249634001704 dimerization interface [polypeptide binding]; other site 1249634001705 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1249634001706 Sulfatase; Region: Sulfatase; pfam00884 1249634001707 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1249634001708 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1249634001709 FeS/SAM binding site; other site 1249634001710 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1249634001711 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1249634001712 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 1249634001713 classical (c) SDRs; Region: SDR_c; cd05233 1249634001714 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1249634001715 NAD(P) binding site [chemical binding]; other site 1249634001716 active site 1249634001717 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 1249634001718 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1249634001719 classical (c) SDRs; Region: SDR_c; cd05233 1249634001720 NAD(P) binding site [chemical binding]; other site 1249634001721 active site 1249634001722 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 1249634001723 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1249634001724 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1249634001725 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 1249634001726 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1249634001727 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 1249634001728 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1249634001729 NAD binding site [chemical binding]; other site 1249634001730 catalytic residues [active] 1249634001731 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 1249634001732 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1249634001733 putative active site [active] 1249634001734 putative metal binding site [ion binding]; other site 1249634001735 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 1249634001736 putative substrate binding pocket [chemical binding]; other site 1249634001737 trimer interface [polypeptide binding]; other site 1249634001738 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 1249634001739 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1249634001740 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1249634001741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634001742 putative substrate translocation pore; other site 1249634001743 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 1249634001744 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1249634001745 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634001746 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 1249634001747 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1249634001748 Flavin Reductases; Region: FlaRed; cl00801 1249634001749 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 1249634001750 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 1249634001751 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1249634001752 non-specific DNA binding site [nucleotide binding]; other site 1249634001753 salt bridge; other site 1249634001754 sequence-specific DNA binding site [nucleotide binding]; other site 1249634001755 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 1249634001756 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1249634001757 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1249634001758 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1249634001759 DNA-binding site [nucleotide binding]; DNA binding site 1249634001760 FCD domain; Region: FCD; pfam07729 1249634001761 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1249634001762 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 1249634001763 NAD binding site [chemical binding]; other site 1249634001764 homotetramer interface [polypeptide binding]; other site 1249634001765 homodimer interface [polypeptide binding]; other site 1249634001766 active site 1249634001767 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1249634001768 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1249634001769 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1249634001770 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 1249634001771 putative active site pocket [active] 1249634001772 metal binding site [ion binding]; metal-binding site 1249634001773 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1249634001774 Amidohydrolase; Region: Amidohydro_2; pfam04909 1249634001775 short chain dehydrogenase; Provisional; Region: PRK08628 1249634001776 classical (c) SDRs; Region: SDR_c; cd05233 1249634001777 NAD(P) binding site [chemical binding]; other site 1249634001778 active site 1249634001779 Domain of unknown function (DUF718); Region: DUF718; pfam05336 1249634001780 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1249634001781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634001782 putative substrate translocation pore; other site 1249634001783 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1249634001784 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1249634001785 metal binding site [ion binding]; metal-binding site 1249634001786 active site 1249634001787 I-site; other site 1249634001788 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 1249634001789 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634001790 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634001791 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1249634001792 putative effector binding pocket; other site 1249634001793 putative dimerization interface [polypeptide binding]; other site 1249634001794 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1249634001795 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1249634001796 active site 1249634001797 catalytic tetrad [active] 1249634001798 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 1249634001799 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 1249634001800 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1249634001801 S-adenosylmethionine binding site [chemical binding]; other site 1249634001802 DNA polymerase III subunit psi; Validated; Region: PRK06856 1249634001803 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 1249634001804 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1249634001805 Coenzyme A binding pocket [chemical binding]; other site 1249634001806 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1249634001807 non-specific DNA binding site [nucleotide binding]; other site 1249634001808 salt bridge; other site 1249634001809 sequence-specific DNA binding site [nucleotide binding]; other site 1249634001810 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1249634001811 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1249634001812 G1 box; other site 1249634001813 putative GEF interaction site [polypeptide binding]; other site 1249634001814 GTP/Mg2+ binding site [chemical binding]; other site 1249634001815 Switch I region; other site 1249634001816 G2 box; other site 1249634001817 G3 box; other site 1249634001818 Switch II region; other site 1249634001819 G4 box; other site 1249634001820 G5 box; other site 1249634001821 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1249634001822 periplasmic protein; Provisional; Region: PRK10568 1249634001823 BON domain; Region: BON; pfam04972 1249634001824 BON domain; Region: BON; pfam04972 1249634001825 CsbD-like; Region: CsbD; cl17424 1249634001826 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1249634001827 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1249634001828 active site 1249634001829 nucleophile elbow; other site 1249634001830 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1249634001831 active site 1249634001832 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1249634001833 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1249634001834 Nucleoside recognition; Region: Gate; pfam07670 1249634001835 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1249634001836 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1249634001837 intersubunit interface [polypeptide binding]; other site 1249634001838 active site 1249634001839 catalytic residue [active] 1249634001840 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1249634001841 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1249634001842 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1249634001843 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1249634001844 phosphopentomutase; Provisional; Region: PRK05362 1249634001845 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1249634001846 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1249634001847 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1249634001848 hypothetical protein; Provisional; Region: PRK11246 1249634001849 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 1249634001850 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1249634001851 motif I; other site 1249634001852 motif II; other site 1249634001853 DNA repair protein RadA; Region: sms; TIGR00416 1249634001854 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1249634001855 Walker A motif/ATP binding site; other site 1249634001856 ATP binding site [chemical binding]; other site 1249634001857 Walker B motif; other site 1249634001858 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1249634001859 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1249634001860 non-specific DNA binding site [nucleotide binding]; other site 1249634001861 salt bridge; other site 1249634001862 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 1249634001863 sequence-specific DNA binding site [nucleotide binding]; other site 1249634001864 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1249634001865 active site 1249634001866 nucleotide binding site [chemical binding]; other site 1249634001867 HIGH motif; other site 1249634001868 KMSKS motif; other site 1249634001869 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1249634001870 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1249634001871 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1249634001872 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1249634001873 ABC transporter; Region: ABC_tran_2; pfam12848 1249634001874 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1249634001875 putative outer membrane lipoprotein; Provisional; Region: PRK09967 1249634001876 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1249634001877 ligand binding site [chemical binding]; other site 1249634001878 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 1249634001879 HAMP domain; Region: HAMP; pfam00672 1249634001880 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1249634001881 metal binding site [ion binding]; metal-binding site 1249634001882 active site 1249634001883 I-site; other site 1249634001884 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 1249634001885 lytic murein transglycosylase; Provisional; Region: PRK11619 1249634001886 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1249634001887 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1249634001888 catalytic residue [active] 1249634001889 Trp operon repressor; Provisional; Region: PRK01381 1249634001890 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 1249634001891 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1249634001892 catalytic core [active] 1249634001893 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 1249634001894 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634001895 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1249634001896 hypothetical protein; Provisional; Region: PRK10756 1249634001897 CreA protein; Region: CreA; pfam05981 1249634001898 two-component response regulator; Provisional; Region: PRK11173 1249634001899 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634001900 active site 1249634001901 phosphorylation site [posttranslational modification] 1249634001902 intermolecular recognition site; other site 1249634001903 dimerization interface [polypeptide binding]; other site 1249634001904 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1249634001905 DNA binding site [nucleotide binding] 1249634001906 putative RNA methyltransferase; Provisional; Region: PRK10433 1249634001907 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 1249634001908 Threonine operon leader; D781_0632; IMG reference gene:2517282022 1249634001909 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 1249634001910 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1249634001911 putative catalytic residues [active] 1249634001912 putative nucleotide binding site [chemical binding]; other site 1249634001913 putative aspartate binding site [chemical binding]; other site 1249634001914 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 1249634001915 dimer interface [polypeptide binding]; other site 1249634001916 putative threonine allosteric regulatory site; other site 1249634001917 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 1249634001918 putative threonine allosteric regulatory site; other site 1249634001919 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1249634001920 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1249634001921 homoserine kinase; Provisional; Region: PRK01212 1249634001922 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1249634001923 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1249634001924 threonine synthase; Validated; Region: PRK09225 1249634001925 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1249634001926 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1249634001927 catalytic residue [active] 1249634001928 hypothetical protein; Validated; Region: PRK02101 1249634001929 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1249634001930 amino acid carrier protein; Region: agcS; TIGR00835 1249634001931 transaldolase-like protein; Provisional; Region: PTZ00411 1249634001932 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1249634001933 active site 1249634001934 dimer interface [polypeptide binding]; other site 1249634001935 catalytic residue [active] 1249634001936 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1249634001937 MPT binding site; other site 1249634001938 trimer interface [polypeptide binding]; other site 1249634001939 metabolite-proton symporter; Region: 2A0106; TIGR00883 1249634001940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634001941 putative substrate translocation pore; other site 1249634001942 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1249634001943 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1249634001944 nucleotide binding site [chemical binding]; other site 1249634001945 chaperone protein DnaJ; Provisional; Region: PRK10767 1249634001946 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1249634001947 HSP70 interaction site [polypeptide binding]; other site 1249634001948 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1249634001949 substrate binding site [polypeptide binding]; other site 1249634001950 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1249634001951 Zn binding sites [ion binding]; other site 1249634001952 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1249634001953 dimer interface [polypeptide binding]; other site 1249634001954 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 1249634001955 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 1249634001956 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634001957 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 1249634001958 putative dimerization interface [polypeptide binding]; other site 1249634001959 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1249634001960 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1249634001961 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1249634001962 active site 1249634001963 Riboflavin kinase; Region: Flavokinase; smart00904 1249634001964 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1249634001965 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1249634001966 active site 1249634001967 HIGH motif; other site 1249634001968 nucleotide binding site [chemical binding]; other site 1249634001969 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1249634001970 active site 1249634001971 KMSKS motif; other site 1249634001972 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1249634001973 tRNA binding surface [nucleotide binding]; other site 1249634001974 anticodon binding site; other site 1249634001975 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1249634001976 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1249634001977 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1249634001978 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1249634001979 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1249634001980 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1249634001981 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1249634001982 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634001983 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1249634001984 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634001985 alpha-galactosidase; Provisional; Region: PRK15076 1249634001986 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1249634001987 NAD binding site [chemical binding]; other site 1249634001988 sugar binding site [chemical binding]; other site 1249634001989 divalent metal binding site [ion binding]; other site 1249634001990 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1249634001991 dimer interface [polypeptide binding]; other site 1249634001992 galactoside permease; Reviewed; Region: lacY; PRK09528 1249634001993 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1249634001994 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1249634001995 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1249634001996 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1249634001997 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1249634001998 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1249634001999 catalytic site [active] 1249634002000 subunit interface [polypeptide binding]; other site 1249634002001 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1249634002002 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1249634002003 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1249634002004 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1249634002005 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1249634002006 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1249634002007 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1249634002008 IMP binding site; other site 1249634002009 dimer interface [polypeptide binding]; other site 1249634002010 interdomain contacts; other site 1249634002011 partial ornithine binding site; other site 1249634002012 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 1249634002013 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 1249634002014 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1249634002015 TrkA-N domain; Region: TrkA_N; pfam02254 1249634002016 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1249634002017 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1249634002018 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1249634002019 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1249634002020 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1249634002021 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1249634002022 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1249634002023 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1249634002024 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1249634002025 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1249634002026 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1249634002027 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1249634002028 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1249634002029 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1249634002030 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1249634002031 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1249634002032 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1249634002033 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1249634002034 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1249634002035 hypothetical protein; Provisional; Region: PRK09917 1249634002036 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1249634002037 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1249634002038 folate binding site [chemical binding]; other site 1249634002039 NADP+ binding site [chemical binding]; other site 1249634002040 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 1249634002041 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 1249634002042 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1249634002043 active site 1249634002044 metal binding site [ion binding]; metal-binding site 1249634002045 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1249634002046 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1249634002047 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1249634002048 S-adenosylmethionine binding site [chemical binding]; other site 1249634002049 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1249634002050 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1249634002051 SurA N-terminal domain; Region: SurA_N; pfam09312 1249634002052 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1249634002053 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1249634002054 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 1249634002055 OstA-like protein; Region: OstA; pfam03968 1249634002056 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1249634002057 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 1249634002058 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1249634002059 putative metal binding site [ion binding]; other site 1249634002060 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1249634002061 HSP70 interaction site [polypeptide binding]; other site 1249634002062 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1249634002063 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1249634002064 active site 1249634002065 ATP-dependent helicase HepA; Validated; Region: PRK04914 1249634002066 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1249634002067 ATP binding site [chemical binding]; other site 1249634002068 putative Mg++ binding site [ion binding]; other site 1249634002069 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1249634002070 nucleotide binding region [chemical binding]; other site 1249634002071 ATP-binding site [chemical binding]; other site 1249634002072 DNA polymerase II; Reviewed; Region: PRK05762 1249634002073 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 1249634002074 active site 1249634002075 catalytic site [active] 1249634002076 substrate binding site [chemical binding]; other site 1249634002077 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 1249634002078 active site 1249634002079 metal-binding site 1249634002080 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1249634002081 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1249634002082 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 1249634002083 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1249634002084 putative valine binding site [chemical binding]; other site 1249634002085 dimer interface [polypeptide binding]; other site 1249634002086 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 1249634002087 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1249634002088 PYR/PP interface [polypeptide binding]; other site 1249634002089 dimer interface [polypeptide binding]; other site 1249634002090 TPP binding site [chemical binding]; other site 1249634002091 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1249634002092 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1249634002093 TPP-binding site [chemical binding]; other site 1249634002094 dimer interface [polypeptide binding]; other site 1249634002095 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 1249634002096 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1249634002097 Walker A/P-loop; other site 1249634002098 ATP binding site [chemical binding]; other site 1249634002099 Q-loop/lid; other site 1249634002100 ABC transporter signature motif; other site 1249634002101 Walker B; other site 1249634002102 D-loop; other site 1249634002103 H-loop/switch region; other site 1249634002104 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 1249634002105 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634002106 dimer interface [polypeptide binding]; other site 1249634002107 conserved gate region; other site 1249634002108 putative PBP binding loops; other site 1249634002109 ABC-ATPase subunit interface; other site 1249634002110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634002111 dimer interface [polypeptide binding]; other site 1249634002112 conserved gate region; other site 1249634002113 putative PBP binding loops; other site 1249634002114 ABC-ATPase subunit interface; other site 1249634002115 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1249634002116 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 1249634002117 transcriptional regulator SgrR; Provisional; Region: PRK13626 1249634002118 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1249634002119 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1249634002120 sugar efflux transporter; Region: 2A0120; TIGR00899 1249634002121 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634002122 putative substrate translocation pore; other site 1249634002123 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1249634002124 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1249634002125 transmembrane helices; other site 1249634002126 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1249634002127 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1249634002128 substrate binding site [chemical binding]; other site 1249634002129 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1249634002130 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1249634002131 substrate binding site [chemical binding]; other site 1249634002132 ligand binding site [chemical binding]; other site 1249634002133 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1249634002134 tartrate dehydrogenase; Region: TTC; TIGR02089 1249634002135 2-isopropylmalate synthase; Validated; Region: PRK00915 1249634002136 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1249634002137 active site 1249634002138 catalytic residues [active] 1249634002139 metal binding site [ion binding]; metal-binding site 1249634002140 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1249634002141 Leucine operon leader; D781_0700; IMG reference gene:2517282090 1249634002142 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1249634002143 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634002144 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 1249634002145 putative substrate binding pocket [chemical binding]; other site 1249634002146 putative dimerization interface [polypeptide binding]; other site 1249634002147 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1249634002148 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1249634002149 acyl-activating enzyme (AAE) consensus motif; other site 1249634002150 putative AMP binding site [chemical binding]; other site 1249634002151 putative active site [active] 1249634002152 putative CoA binding site [chemical binding]; other site 1249634002153 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 1249634002154 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1249634002155 PYR/PP interface [polypeptide binding]; other site 1249634002156 dimer interface [polypeptide binding]; other site 1249634002157 TPP binding site [chemical binding]; other site 1249634002158 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1249634002159 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1249634002160 TPP-binding site [chemical binding]; other site 1249634002161 dimer interface [polypeptide binding]; other site 1249634002162 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1249634002163 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1249634002164 putative valine binding site [chemical binding]; other site 1249634002165 dimer interface [polypeptide binding]; other site 1249634002166 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1249634002167 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 1249634002168 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1249634002169 DNA binding site [nucleotide binding] 1249634002170 domain linker motif; other site 1249634002171 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1249634002172 dimerization interface [polypeptide binding]; other site 1249634002173 ligand binding site [chemical binding]; other site 1249634002174 cell division protein MraZ; Reviewed; Region: PRK00326 1249634002175 MraZ protein; Region: MraZ; pfam02381 1249634002176 MraZ protein; Region: MraZ; pfam02381 1249634002177 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 1249634002178 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1249634002179 cell division protein FtsL; Provisional; Region: PRK10772 1249634002180 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1249634002181 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1249634002182 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1249634002183 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1249634002184 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1249634002185 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1249634002186 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1249634002187 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 1249634002188 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1249634002189 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1249634002190 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1249634002191 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1249634002192 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1249634002193 Mg++ binding site [ion binding]; other site 1249634002194 putative catalytic motif [active] 1249634002195 putative substrate binding site [chemical binding]; other site 1249634002196 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 1249634002197 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1249634002198 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1249634002199 cell division protein FtsW; Provisional; Region: PRK10774 1249634002200 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1249634002201 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1249634002202 active site 1249634002203 homodimer interface [polypeptide binding]; other site 1249634002204 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1249634002205 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1249634002206 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1249634002207 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1249634002208 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1249634002209 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1249634002210 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1249634002211 cell division protein FtsQ; Provisional; Region: PRK10775 1249634002212 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1249634002213 Cell division protein FtsQ; Region: FtsQ; pfam03799 1249634002214 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 1249634002215 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1249634002216 Cell division protein FtsA; Region: FtsA; pfam14450 1249634002217 cell division protein FtsZ; Validated; Region: PRK09330 1249634002218 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1249634002219 nucleotide binding site [chemical binding]; other site 1249634002220 SulA interaction site; other site 1249634002221 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1249634002222 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1249634002223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4701 1249634002224 SecA regulator SecM; Provisional; Region: PRK02943 1249634002225 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1249634002226 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1249634002227 SEC-C motif; Region: SEC-C; pfam02810 1249634002228 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1249634002229 active site 1249634002230 8-oxo-dGMP binding site [chemical binding]; other site 1249634002231 nudix motif; other site 1249634002232 metal binding site [ion binding]; metal-binding site 1249634002233 DNA gyrase inhibitor; Reviewed; Region: PRK00418 1249634002234 hypothetical protein; Provisional; Region: PRK05287 1249634002235 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1249634002236 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1249634002237 CoA-binding site [chemical binding]; other site 1249634002238 ATP-binding [chemical binding]; other site 1249634002239 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 1249634002240 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1249634002241 active site 1249634002242 type IV pilin biogenesis protein; Provisional; Region: PRK10573 1249634002243 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1249634002244 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1249634002245 hypothetical protein; Provisional; Region: PRK10436 1249634002246 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1249634002247 Walker A motif; other site 1249634002248 ATP binding site [chemical binding]; other site 1249634002249 Walker B motif; other site 1249634002250 putative major pilin subunit; Provisional; Region: PRK10574 1249634002251 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1249634002252 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 1249634002253 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1249634002254 dimerization interface [polypeptide binding]; other site 1249634002255 active site 1249634002256 regulatory protein AmpE; Provisional; Region: PRK10987 1249634002257 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1249634002258 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1249634002259 inhibitor-cofactor binding pocket; inhibition site 1249634002260 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634002261 catalytic residue [active] 1249634002262 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1249634002263 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1249634002264 Cl- selectivity filter; other site 1249634002265 Cl- binding residues [ion binding]; other site 1249634002266 pore gating glutamate residue; other site 1249634002267 dimer interface [polypeptide binding]; other site 1249634002268 H+/Cl- coupling transport residue; other site 1249634002269 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1249634002270 hypothetical protein; Provisional; Region: PRK10578 1249634002271 UPF0126 domain; Region: UPF0126; pfam03458 1249634002272 UPF0126 domain; Region: UPF0126; pfam03458 1249634002273 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 1249634002274 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1249634002275 cobalamin binding residues [chemical binding]; other site 1249634002276 putative BtuC binding residues; other site 1249634002277 dimer interface [polypeptide binding]; other site 1249634002278 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1249634002279 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1249634002280 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 1249634002281 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1249634002282 Zn2+ binding site [ion binding]; other site 1249634002283 Mg2+ binding site [ion binding]; other site 1249634002284 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1249634002285 serine endoprotease; Provisional; Region: PRK10942 1249634002286 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1249634002287 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1249634002288 protein binding site [polypeptide binding]; other site 1249634002289 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1249634002290 protein binding site [polypeptide binding]; other site 1249634002291 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 1249634002292 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1249634002293 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1249634002294 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1249634002295 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1249634002296 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1249634002297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634002298 D-galactonate transporter; Region: 2A0114; TIGR00893 1249634002299 putative substrate translocation pore; other site 1249634002300 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1249634002301 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1249634002302 active site 1249634002303 tetramer interface [polypeptide binding]; other site 1249634002304 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1249634002305 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1249634002306 active site 1249634002307 tetramer interface [polypeptide binding]; other site 1249634002308 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 1249634002309 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 1249634002310 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1249634002311 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1249634002312 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 1249634002313 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 1249634002314 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1249634002315 dimerization interface [polypeptide binding]; other site 1249634002316 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1249634002317 dimer interface [polypeptide binding]; other site 1249634002318 phosphorylation site [posttranslational modification] 1249634002319 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1249634002320 ATP binding site [chemical binding]; other site 1249634002321 Mg2+ binding site [ion binding]; other site 1249634002322 G-X-G motif; other site 1249634002323 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 1249634002324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634002325 active site 1249634002326 phosphorylation site [posttranslational modification] 1249634002327 intermolecular recognition site; other site 1249634002328 dimerization interface [polypeptide binding]; other site 1249634002329 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1249634002330 putative binding surface; other site 1249634002331 active site 1249634002332 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1249634002333 TRAM domain; Region: TRAM; pfam01938 1249634002334 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1249634002335 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1249634002336 S-adenosylmethionine binding site [chemical binding]; other site 1249634002337 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 1249634002338 HD domain; Region: HD_4; pfam13328 1249634002339 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1249634002340 synthetase active site [active] 1249634002341 NTP binding site [chemical binding]; other site 1249634002342 metal binding site [ion binding]; metal-binding site 1249634002343 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1249634002344 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1249634002345 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1249634002346 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1249634002347 homodimer interface [polypeptide binding]; other site 1249634002348 metal binding site [ion binding]; metal-binding site 1249634002349 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1249634002350 homodimer interface [polypeptide binding]; other site 1249634002351 active site 1249634002352 putative chemical substrate binding site [chemical binding]; other site 1249634002353 metal binding site [ion binding]; metal-binding site 1249634002354 CTP synthetase; Validated; Region: pyrG; PRK05380 1249634002355 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1249634002356 Catalytic site [active] 1249634002357 active site 1249634002358 UTP binding site [chemical binding]; other site 1249634002359 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1249634002360 active site 1249634002361 putative oxyanion hole; other site 1249634002362 catalytic triad [active] 1249634002363 enolase; Provisional; Region: eno; PRK00077 1249634002364 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1249634002365 dimer interface [polypeptide binding]; other site 1249634002366 metal binding site [ion binding]; metal-binding site 1249634002367 substrate binding pocket [chemical binding]; other site 1249634002368 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1249634002369 methionine gamma-lyase; Provisional; Region: PRK07503 1249634002370 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1249634002371 homodimer interface [polypeptide binding]; other site 1249634002372 substrate-cofactor binding pocket; other site 1249634002373 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634002374 catalytic residue [active] 1249634002375 putative proline-specific permease; Provisional; Region: proY; PRK10580 1249634002376 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1249634002377 active sites [active] 1249634002378 tetramer interface [polypeptide binding]; other site 1249634002379 urocanate hydratase; Provisional; Region: PRK05414 1249634002380 benzoate transport; Region: 2A0115; TIGR00895 1249634002381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634002382 putative substrate translocation pore; other site 1249634002383 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634002384 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1249634002385 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1249634002386 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1249634002387 active site 1249634002388 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 1249634002389 Flavodoxin; Region: Flavodoxin_1; pfam00258 1249634002390 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1249634002391 FAD binding pocket [chemical binding]; other site 1249634002392 FAD binding motif [chemical binding]; other site 1249634002393 catalytic residues [active] 1249634002394 NAD binding pocket [chemical binding]; other site 1249634002395 phosphate binding motif [ion binding]; other site 1249634002396 beta-alpha-beta structure motif; other site 1249634002397 sulfite reductase subunit beta; Provisional; Region: PRK13504 1249634002398 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1249634002399 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1249634002400 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1249634002401 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1249634002402 Active Sites [active] 1249634002403 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 1249634002404 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1249634002405 metal binding site [ion binding]; metal-binding site 1249634002406 siroheme synthase; Provisional; Region: cysG; PRK10637 1249634002407 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1249634002408 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1249634002409 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1249634002410 active site 1249634002411 SAM binding site [chemical binding]; other site 1249634002412 homodimer interface [polypeptide binding]; other site 1249634002413 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1249634002414 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1249634002415 Active Sites [active] 1249634002416 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 1249634002417 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1249634002418 CysD dimerization site [polypeptide binding]; other site 1249634002419 G1 box; other site 1249634002420 putative GEF interaction site [polypeptide binding]; other site 1249634002421 GTP/Mg2+ binding site [chemical binding]; other site 1249634002422 Switch I region; other site 1249634002423 G2 box; other site 1249634002424 G3 box; other site 1249634002425 Switch II region; other site 1249634002426 G4 box; other site 1249634002427 G5 box; other site 1249634002428 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1249634002429 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1249634002430 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1249634002431 ligand-binding site [chemical binding]; other site 1249634002432 hypothetical protein; Provisional; Region: PRK10726 1249634002433 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1249634002434 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1249634002435 Walker A/P-loop; other site 1249634002436 ATP binding site [chemical binding]; other site 1249634002437 Q-loop/lid; other site 1249634002438 ABC transporter signature motif; other site 1249634002439 Walker B; other site 1249634002440 D-loop; other site 1249634002441 H-loop/switch region; other site 1249634002442 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634002443 dimer interface [polypeptide binding]; other site 1249634002444 conserved gate region; other site 1249634002445 putative PBP binding loops; other site 1249634002446 ABC-ATPase subunit interface; other site 1249634002447 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1249634002448 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1249634002449 substrate binding pocket [chemical binding]; other site 1249634002450 membrane-bound complex binding site; other site 1249634002451 hinge residues; other site 1249634002452 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 1249634002453 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1249634002454 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1249634002455 substrate binding site; other site 1249634002456 dimer interface; other site 1249634002457 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1249634002458 homotrimer interaction site [polypeptide binding]; other site 1249634002459 zinc binding site [ion binding]; other site 1249634002460 CDP-binding sites; other site 1249634002461 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 1249634002462 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 1249634002463 Permutation of conserved domain; other site 1249634002464 active site 1249634002465 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1249634002466 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1249634002467 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1249634002468 S-adenosylmethionine binding site [chemical binding]; other site 1249634002469 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 1249634002470 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1249634002471 Peptidase family M23; Region: Peptidase_M23; pfam01551 1249634002472 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 1249634002473 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1249634002474 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1249634002475 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1249634002476 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1249634002477 DNA binding residues [nucleotide binding] 1249634002478 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1249634002479 MutS domain I; Region: MutS_I; pfam01624 1249634002480 MutS domain II; Region: MutS_II; pfam05188 1249634002481 MutS domain III; Region: MutS_III; pfam05192 1249634002482 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1249634002483 Walker A/P-loop; other site 1249634002484 ATP binding site [chemical binding]; other site 1249634002485 Q-loop/lid; other site 1249634002486 ABC transporter signature motif; other site 1249634002487 Walker B; other site 1249634002488 D-loop; other site 1249634002489 H-loop/switch region; other site 1249634002490 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1249634002491 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1249634002492 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1249634002493 catalytic residue [active] 1249634002494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634002495 putative substrate translocation pore; other site 1249634002496 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1249634002497 hypothetical protein; Validated; Region: PRK03661 1249634002498 recombinase A; Provisional; Region: recA; PRK09354 1249634002499 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1249634002500 hexamer interface [polypeptide binding]; other site 1249634002501 Walker A motif; other site 1249634002502 ATP binding site [chemical binding]; other site 1249634002503 Walker B motif; other site 1249634002504 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1249634002505 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1249634002506 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1249634002507 motif 1; other site 1249634002508 active site 1249634002509 motif 2; other site 1249634002510 motif 3; other site 1249634002511 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1249634002512 DHHA1 domain; Region: DHHA1; pfam02272 1249634002513 carbon storage regulator; Provisional; Region: PRK01712 1249634002514 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 1249634002515 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1249634002516 active site 1249634002517 motif I; other site 1249634002518 motif II; other site 1249634002519 Predicted membrane protein [Function unknown]; Region: COG1238 1249634002520 glutamate--cysteine ligase; Provisional; Region: PRK02107 1249634002521 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1249634002522 hypothetical protein; Provisional; Region: PRK11573 1249634002523 Domain of unknown function DUF21; Region: DUF21; pfam01595 1249634002524 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1249634002525 Transporter associated domain; Region: CorC_HlyC; smart01091 1249634002526 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 1249634002527 signal recognition particle protein; Provisional; Region: PRK10867 1249634002528 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1249634002529 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1249634002530 P loop; other site 1249634002531 GTP binding site [chemical binding]; other site 1249634002532 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1249634002533 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1249634002534 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1249634002535 RimM N-terminal domain; Region: RimM; pfam01782 1249634002536 PRC-barrel domain; Region: PRC; pfam05239 1249634002537 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1249634002538 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1249634002539 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1249634002540 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1249634002541 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1249634002542 phage tail protein, P2 protein I family; Region: tail_P2_I; TIGR01634 1249634002543 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 1249634002544 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1249634002545 Phage protein U [General function prediction only]; Region: COG3499 1249634002546 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 1249634002547 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1249634002548 major tail tube protein; Provisional; Region: FII; PHA02600 1249634002549 major tail sheath protein; Provisional; Region: FI; PHA02560 1249634002550 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1249634002551 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1249634002552 Phage Tail Collar Domain; Region: Collar; pfam07484 1249634002553 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 1249634002554 baseplate assembly protein; Provisional; Region: J; PHA02568 1249634002555 baseplate wedge subunit; Provisional; Region: W; PHA02516 1249634002556 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1249634002557 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 1249634002558 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 1249634002559 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1249634002560 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 1249634002561 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1249634002562 catalytic residues [active] 1249634002563 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 1249634002564 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 1249634002565 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 1249634002566 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 1249634002567 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1249634002568 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1249634002569 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1249634002570 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 1249634002571 Chorismate mutase type II; Region: CM_2; cl00693 1249634002572 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1249634002573 prephenate dehydrogenase; Validated; Region: PRK08507 1249634002574 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 1249634002575 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 1249634002576 Prephenate dehydratase; Region: PDT; pfam00800 1249634002577 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1249634002578 putative L-Phe binding site [chemical binding]; other site 1249634002579 Phenylalanine leader peptide; D781_0842; IMG reference gene:2517282232 1249634002580 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1249634002581 30S subunit binding site; other site 1249634002582 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 1249634002583 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1249634002584 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1249634002585 RNA binding surface [nucleotide binding]; other site 1249634002586 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1249634002587 active site 1249634002588 hypothetical protein; Provisional; Region: PRK10723 1249634002589 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1249634002590 protein disaggregation chaperone; Provisional; Region: PRK10865 1249634002591 Clp amino terminal domain; Region: Clp_N; pfam02861 1249634002592 Clp amino terminal domain; Region: Clp_N; pfam02861 1249634002593 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1249634002594 Walker A motif; other site 1249634002595 ATP binding site [chemical binding]; other site 1249634002596 Walker B motif; other site 1249634002597 arginine finger; other site 1249634002598 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1249634002599 Walker A motif; other site 1249634002600 ATP binding site [chemical binding]; other site 1249634002601 Walker B motif; other site 1249634002602 arginine finger; other site 1249634002603 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1249634002604 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 1249634002605 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1249634002606 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1249634002607 putative acyl-acceptor binding pocket; other site 1249634002608 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1249634002609 acyl carrier protein; Provisional; Region: PRK05350 1249634002610 Predicted membrane protein [Function unknown]; Region: COG4648 1249634002611 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1249634002612 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1249634002613 acyl-activating enzyme (AAE) consensus motif; other site 1249634002614 AMP binding site [chemical binding]; other site 1249634002615 active site 1249634002616 CoA binding site [chemical binding]; other site 1249634002617 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 1249634002618 active site 2 [active] 1249634002619 dimer interface [polypeptide binding]; other site 1249634002620 active site 1 [active] 1249634002621 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1249634002622 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1249634002623 Ligand binding site; other site 1249634002624 Putative Catalytic site; other site 1249634002625 DXD motif; other site 1249634002626 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1249634002627 putative acyl-acceptor binding pocket; other site 1249634002628 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1249634002629 active site 1249634002630 Uncharacterized protein conserved in bacteria (DUF2195); Region: DUF2195; cl02042 1249634002631 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1249634002632 Predicted exporter [General function prediction only]; Region: COG4258 1249634002633 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 1249634002634 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 1249634002635 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1249634002636 dimer interface [polypeptide binding]; other site 1249634002637 active site 1249634002638 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1249634002639 active site 2 [active] 1249634002640 active site 1 [active] 1249634002641 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1249634002642 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 1249634002643 NAD(P) binding site [chemical binding]; other site 1249634002644 homotetramer interface [polypeptide binding]; other site 1249634002645 homodimer interface [polypeptide binding]; other site 1249634002646 active site 1249634002647 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 1249634002648 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1249634002649 dimer interface [polypeptide binding]; other site 1249634002650 active site 1249634002651 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1249634002652 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1249634002653 active site 1249634002654 catalytic tetrad [active] 1249634002655 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634002656 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634002657 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1249634002658 dimerization interface [polypeptide binding]; other site 1249634002659 hypothetical protein; Provisional; Region: PRK05421 1249634002660 putative catalytic site [active] 1249634002661 putative phosphate binding site [ion binding]; other site 1249634002662 putative metal binding site [ion binding]; other site 1249634002663 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 1249634002664 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1249634002665 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1249634002666 catalytic residue [active] 1249634002667 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1249634002668 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1249634002669 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 1249634002670 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1249634002671 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1249634002672 RNA/DNA hybrid binding site [nucleotide binding]; other site 1249634002673 active site 1249634002674 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1249634002675 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1249634002676 active site 1249634002677 catalytic site [active] 1249634002678 substrate binding site [chemical binding]; other site 1249634002679 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1249634002680 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 1249634002681 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1249634002682 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1249634002683 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1249634002684 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1249634002685 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1249634002686 N- and C-terminal domain interface [polypeptide binding]; other site 1249634002687 D-xylulose kinase; Region: XylB; TIGR01312 1249634002688 active site 1249634002689 MgATP binding site [chemical binding]; other site 1249634002690 catalytic site [active] 1249634002691 metal binding site [ion binding]; metal-binding site 1249634002692 xylulose binding site [chemical binding]; other site 1249634002693 homodimer interface [polypeptide binding]; other site 1249634002694 polyol permease family; Region: 2A0118; TIGR00897 1249634002695 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634002696 putative substrate translocation pore; other site 1249634002697 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1249634002698 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1249634002699 N-terminal plug; other site 1249634002700 ligand-binding site [chemical binding]; other site 1249634002701 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 1249634002702 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1249634002703 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1249634002704 IucA / IucC family; Region: IucA_IucC; pfam04183 1249634002705 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1249634002706 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1249634002707 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1249634002708 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1249634002709 IucA / IucC family; Region: IucA_IucC; pfam04183 1249634002710 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1249634002711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634002712 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1249634002713 putative substrate translocation pore; other site 1249634002714 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1249634002715 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1249634002716 FAD binding pocket [chemical binding]; other site 1249634002717 FAD binding motif [chemical binding]; other site 1249634002718 phosphate binding motif [ion binding]; other site 1249634002719 NAD binding pocket [chemical binding]; other site 1249634002720 C-N hydrolase family amidase; Provisional; Region: PRK10438 1249634002721 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 1249634002722 putative active site [active] 1249634002723 catalytic triad [active] 1249634002724 dimer interface [polypeptide binding]; other site 1249634002725 multimer interface [polypeptide binding]; other site 1249634002726 methionine aminotransferase; Validated; Region: PRK09082 1249634002727 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1249634002728 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634002729 homodimer interface [polypeptide binding]; other site 1249634002730 catalytic residue [active] 1249634002731 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 1249634002732 intersubunit interface [polypeptide binding]; other site 1249634002733 active site 1249634002734 Zn2+ binding site [ion binding]; other site 1249634002735 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 1249634002736 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1249634002737 Cupin domain; Region: Cupin_2; cl17218 1249634002738 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1249634002739 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1249634002740 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 1249634002741 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1249634002742 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1249634002743 active site 1249634002744 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1249634002745 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1249634002746 dimer interface [polypeptide binding]; other site 1249634002747 active site 1249634002748 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1249634002749 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1249634002750 putative active site [active] 1249634002751 putative dimer interface [polypeptide binding]; other site 1249634002752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1249634002753 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 1249634002754 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1249634002755 E3 interaction surface; other site 1249634002756 lipoyl attachment site [posttranslational modification]; other site 1249634002757 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 1249634002758 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 1249634002759 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 1249634002760 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 1249634002761 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 1249634002762 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 1249634002763 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 1249634002764 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1249634002765 catalytic loop [active] 1249634002766 iron binding site [ion binding]; other site 1249634002767 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 1249634002768 FAD binding pocket [chemical binding]; other site 1249634002769 FAD binding motif [chemical binding]; other site 1249634002770 phosphate binding motif [ion binding]; other site 1249634002771 beta-alpha-beta structure motif; other site 1249634002772 NAD binding pocket [chemical binding]; other site 1249634002773 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1249634002774 ApbE family; Region: ApbE; pfam02424 1249634002775 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991 1249634002776 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1249634002777 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1249634002778 active site 1249634002779 catalytic site [active] 1249634002780 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1249634002781 active site 1249634002782 DNA polymerase IV; Validated; Region: PRK02406 1249634002783 DNA binding site [nucleotide binding] 1249634002784 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 1249634002785 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 1249634002786 metal binding site [ion binding]; metal-binding site 1249634002787 dimer interface [polypeptide binding]; other site 1249634002788 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1249634002789 active site 1249634002790 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 1249634002791 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 1249634002792 gamma-glutamyl kinase; Provisional; Region: PRK05429 1249634002793 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1249634002794 nucleotide binding site [chemical binding]; other site 1249634002795 homotetrameric interface [polypeptide binding]; other site 1249634002796 putative phosphate binding site [ion binding]; other site 1249634002797 putative allosteric binding site; other site 1249634002798 PUA domain; Region: PUA; pfam01472 1249634002799 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1249634002800 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1249634002801 putative catalytic cysteine [active] 1249634002802 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442 1249634002803 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 1249634002804 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 1249634002805 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 1249634002806 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1249634002807 lac repressor; Reviewed; Region: lacI; PRK09526 1249634002808 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1249634002809 DNA binding site [nucleotide binding] 1249634002810 domain linker motif; other site 1249634002811 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1249634002812 ligand binding site [chemical binding]; other site 1249634002813 dimerization interface (open form) [polypeptide binding]; other site 1249634002814 dimerization interface (closed form) [polypeptide binding]; other site 1249634002815 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 1249634002816 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1249634002817 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1249634002818 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1249634002819 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 1249634002820 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 1249634002821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634002822 putative substrate translocation pore; other site 1249634002823 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1249634002824 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1249634002825 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1249634002826 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1249634002827 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 1249634002828 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 1249634002829 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634002830 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1249634002831 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1249634002832 NAD(P) binding site [chemical binding]; other site 1249634002833 catalytic residues [active] 1249634002834 leucine export protein LeuE; Provisional; Region: PRK10958 1249634002835 tellurite resistance protein TehB; Provisional; Region: PRK11207 1249634002836 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1249634002837 S-adenosylmethionine binding site [chemical binding]; other site 1249634002838 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 1249634002839 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1249634002840 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1249634002841 dimer interface [polypeptide binding]; other site 1249634002842 PYR/PP interface [polypeptide binding]; other site 1249634002843 TPP binding site [chemical binding]; other site 1249634002844 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1249634002845 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1249634002846 TPP-binding site [chemical binding]; other site 1249634002847 dimer interface [polypeptide binding]; other site 1249634002848 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 1249634002849 hypothetical protein; Provisional; Region: PRK11667 1249634002850 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 1249634002851 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1249634002852 LysR family transcriptional regulator; Provisional; Region: PRK14997 1249634002853 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634002854 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 1249634002855 putative effector binding pocket; other site 1249634002856 putative dimerization interface [polypeptide binding]; other site 1249634002857 Pirin-related protein [General function prediction only]; Region: COG1741 1249634002858 Pirin; Region: Pirin; pfam02678 1249634002859 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1249634002860 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 1249634002861 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 1249634002862 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1249634002863 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1249634002864 salt bridge; other site 1249634002865 non-specific DNA binding site [nucleotide binding]; other site 1249634002866 sequence-specific DNA binding site [nucleotide binding]; other site 1249634002867 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1249634002868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1249634002869 S-adenosylmethionine binding site [chemical binding]; other site 1249634002870 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1249634002871 amphipathic channel; other site 1249634002872 Asn-Pro-Ala signature motifs; other site 1249634002873 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1249634002874 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1249634002875 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1249634002876 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1249634002877 S-adenosylmethionine binding site [chemical binding]; other site 1249634002878 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 1249634002879 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 1249634002880 putative ligand binding residues [chemical binding]; other site 1249634002881 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1249634002882 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1249634002883 N-terminal plug; other site 1249634002884 ligand-binding site [chemical binding]; other site 1249634002885 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1249634002886 Coenzyme A binding pocket [chemical binding]; other site 1249634002887 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1249634002888 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1249634002889 ADP binding site [chemical binding]; other site 1249634002890 magnesium binding site [ion binding]; other site 1249634002891 putative shikimate binding site; other site 1249634002892 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1249634002893 Helix-turn-helix domain; Region: HTH_18; pfam12833 1249634002894 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634002895 SnoaL-like domain; Region: SnoaL_2; pfam12680 1249634002896 hypothetical protein; Provisional; Region: PRK10579 1249634002897 recombination associated protein; Reviewed; Region: rdgC; PRK00321 1249634002898 fructokinase; Reviewed; Region: PRK09557 1249634002899 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1249634002900 nucleotide binding site [chemical binding]; other site 1249634002901 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1249634002902 AAA domain; Region: AAA_23; pfam13476 1249634002903 Walker A/P-loop; other site 1249634002904 ATP binding site [chemical binding]; other site 1249634002905 Q-loop/lid; other site 1249634002906 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1249634002907 ABC transporter signature motif; other site 1249634002908 Walker B; other site 1249634002909 D-loop; other site 1249634002910 H-loop/switch region; other site 1249634002911 exonuclease subunit SbcD; Provisional; Region: PRK10966 1249634002912 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1249634002913 active site 1249634002914 metal binding site [ion binding]; metal-binding site 1249634002915 DNA binding site [nucleotide binding] 1249634002916 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1249634002917 transcriptional regulator PhoB; Provisional; Region: PRK10161 1249634002918 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634002919 active site 1249634002920 phosphorylation site [posttranslational modification] 1249634002921 intermolecular recognition site; other site 1249634002922 dimerization interface [polypeptide binding]; other site 1249634002923 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1249634002924 DNA binding site [nucleotide binding] 1249634002925 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 1249634002926 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 1249634002927 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1249634002928 putative active site [active] 1249634002929 heme pocket [chemical binding]; other site 1249634002930 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1249634002931 dimer interface [polypeptide binding]; other site 1249634002932 phosphorylation site [posttranslational modification] 1249634002933 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1249634002934 ATP binding site [chemical binding]; other site 1249634002935 Mg2+ binding site [ion binding]; other site 1249634002936 G-X-G motif; other site 1249634002937 PBP superfamily domain; Region: PBP_like_2; cl17296 1249634002938 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1249634002939 substrate binding site [chemical binding]; other site 1249634002940 THF binding site; other site 1249634002941 zinc-binding site [ion binding]; other site 1249634002942 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1249634002943 putative proline-specific permease; Provisional; Region: proY; PRK10580 1249634002944 Spore germination protein; Region: Spore_permease; cl17796 1249634002945 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1249634002946 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1249634002947 maltodextrin glucosidase; Provisional; Region: PRK10785 1249634002948 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1249634002949 homodimer interface [polypeptide binding]; other site 1249634002950 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1249634002951 active site 1249634002952 homodimer interface [polypeptide binding]; other site 1249634002953 catalytic site [active] 1249634002954 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1249634002955 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1249634002956 peroxidase; Provisional; Region: PRK15000 1249634002957 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1249634002958 dimer interface [polypeptide binding]; other site 1249634002959 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1249634002960 catalytic triad [active] 1249634002961 peroxidatic and resolving cysteines [active] 1249634002962 Protein of unknown function, DUF479; Region: DUF479; cl01203 1249634002963 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1249634002964 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1249634002965 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1249634002966 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1249634002967 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1249634002968 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1249634002969 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1249634002970 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1249634002971 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1249634002972 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1249634002973 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1249634002974 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1249634002975 Protein export membrane protein; Region: SecD_SecF; pfam02355 1249634002976 hypothetical protein; Provisional; Region: PRK11530 1249634002977 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1249634002978 ATP cone domain; Region: ATP-cone; pfam03477 1249634002979 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1249634002980 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1249634002981 catalytic motif [active] 1249634002982 Zn binding site [ion binding]; other site 1249634002983 RibD C-terminal domain; Region: RibD_C; cl17279 1249634002984 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1249634002985 homopentamer interface [polypeptide binding]; other site 1249634002986 active site 1249634002987 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1249634002988 putative RNA binding site [nucleotide binding]; other site 1249634002989 thiamine monophosphate kinase; Provisional; Region: PRK05731 1249634002990 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1249634002991 ATP binding site [chemical binding]; other site 1249634002992 dimerization interface [polypeptide binding]; other site 1249634002993 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1249634002994 tetramer interfaces [polypeptide binding]; other site 1249634002995 binuclear metal-binding site [ion binding]; other site 1249634002996 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1249634002997 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1249634002998 TPP-binding site; other site 1249634002999 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1249634003000 PYR/PP interface [polypeptide binding]; other site 1249634003001 dimer interface [polypeptide binding]; other site 1249634003002 TPP binding site [chemical binding]; other site 1249634003003 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1249634003004 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1249634003005 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1249634003006 substrate binding pocket [chemical binding]; other site 1249634003007 chain length determination region; other site 1249634003008 substrate-Mg2+ binding site; other site 1249634003009 catalytic residues [active] 1249634003010 aspartate-rich region 1; other site 1249634003011 active site lid residues [active] 1249634003012 aspartate-rich region 2; other site 1249634003013 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1249634003014 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 1249634003015 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1249634003016 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1249634003017 Ligand Binding Site [chemical binding]; other site 1249634003018 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1249634003019 active site residue [active] 1249634003020 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 1249634003021 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1249634003022 conserved cys residue [active] 1249634003023 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1249634003024 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1249634003025 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1249634003026 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1249634003027 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1249634003028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634003029 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1249634003030 putative substrate translocation pore; other site 1249634003031 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 1249634003032 UbiA prenyltransferase family; Region: UbiA; pfam01040 1249634003033 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 1249634003034 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1249634003035 Subunit I/III interface [polypeptide binding]; other site 1249634003036 Subunit III/IV interface [polypeptide binding]; other site 1249634003037 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1249634003038 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1249634003039 D-pathway; other site 1249634003040 Putative ubiquinol binding site [chemical binding]; other site 1249634003041 Low-spin heme (heme b) binding site [chemical binding]; other site 1249634003042 Putative water exit pathway; other site 1249634003043 Binuclear center (heme o3/CuB) [ion binding]; other site 1249634003044 K-pathway; other site 1249634003045 Putative proton exit pathway; other site 1249634003046 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 1249634003047 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1249634003048 Acetyl-coenzyme A transporter 1; Region: Acatn; pfam13000 1249634003049 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634003050 hypothetical protein; Provisional; Region: PRK11627 1249634003051 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 1249634003052 transcriptional regulator BolA; Provisional; Region: PRK11628 1249634003053 trigger factor; Provisional; Region: tig; PRK01490 1249634003054 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1249634003055 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1249634003056 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1249634003057 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1249634003058 oligomer interface [polypeptide binding]; other site 1249634003059 active site residues [active] 1249634003060 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1249634003061 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1249634003062 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1249634003063 Walker A motif; other site 1249634003064 ATP binding site [chemical binding]; other site 1249634003065 Walker B motif; other site 1249634003066 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1249634003067 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 1249634003068 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1249634003069 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1249634003070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1249634003071 Walker A motif; other site 1249634003072 ATP binding site [chemical binding]; other site 1249634003073 Walker B motif; other site 1249634003074 arginine finger; other site 1249634003075 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1249634003076 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1249634003077 IHF dimer interface [polypeptide binding]; other site 1249634003078 IHF - DNA interface [nucleotide binding]; other site 1249634003079 periplasmic folding chaperone; Provisional; Region: PRK10788 1249634003080 SurA N-terminal domain; Region: SurA_N_3; cl07813 1249634003081 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1249634003082 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1249634003083 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1249634003084 active site 1249634003085 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1249634003086 Ligand Binding Site [chemical binding]; other site 1249634003087 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1249634003088 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1249634003089 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1249634003090 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 1249634003091 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1249634003092 active site 1249634003093 motif I; other site 1249634003094 motif II; other site 1249634003095 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1249634003096 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1249634003097 EamA-like transporter family; Region: EamA; pfam00892 1249634003098 EamA-like transporter family; Region: EamA; pfam00892 1249634003099 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1249634003100 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1249634003101 putative DNA binding site [nucleotide binding]; other site 1249634003102 putative Zn2+ binding site [ion binding]; other site 1249634003103 AsnC family; Region: AsnC_trans_reg; pfam01037 1249634003104 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1249634003105 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1249634003106 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1249634003107 Walker A/P-loop; other site 1249634003108 ATP binding site [chemical binding]; other site 1249634003109 Q-loop/lid; other site 1249634003110 ABC transporter signature motif; other site 1249634003111 Walker B; other site 1249634003112 D-loop; other site 1249634003113 H-loop/switch region; other site 1249634003114 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 1249634003115 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1249634003116 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1249634003117 Walker A/P-loop; other site 1249634003118 ATP binding site [chemical binding]; other site 1249634003119 Q-loop/lid; other site 1249634003120 ABC transporter signature motif; other site 1249634003121 Walker B; other site 1249634003122 D-loop; other site 1249634003123 H-loop/switch region; other site 1249634003124 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 1249634003125 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1249634003126 ammonium transporter; Provisional; Region: PRK10666 1249634003127 acyl-CoA thioesterase II; Provisional; Region: PRK10526 1249634003128 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1249634003129 active site 1249634003130 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1249634003131 catalytic triad [active] 1249634003132 dimer interface [polypeptide binding]; other site 1249634003133 azoreductase; Reviewed; Region: PRK00170 1249634003134 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1249634003135 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634003136 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634003137 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 1249634003138 putative effector binding pocket; other site 1249634003139 putative dimerization interface [polypeptide binding]; other site 1249634003140 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 1249634003141 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1249634003142 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1249634003143 DNA binding site [nucleotide binding] 1249634003144 active site 1249634003145 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1249634003146 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1249634003147 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1249634003148 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1249634003149 NAD(P) binding site [chemical binding]; other site 1249634003150 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1249634003151 Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958 1249634003152 succinylarginine dihydrolase; Provisional; Region: PRK13281 1249634003153 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1249634003154 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1249634003155 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1249634003156 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1249634003157 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1249634003158 active site 1249634003159 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1249634003160 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634003161 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634003162 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1249634003163 dimerization interface [polypeptide binding]; other site 1249634003164 gene expression modulator; Provisional; Region: PRK10945 1249634003165 Hha toxicity attenuator; Provisional; Region: PRK10667 1249634003166 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 1249634003167 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1249634003168 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1249634003169 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1249634003170 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1249634003171 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1249634003172 metal binding site [ion binding]; metal-binding site 1249634003173 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1249634003174 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1249634003175 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 1249634003176 Protein export membrane protein; Region: SecD_SecF; cl14618 1249634003177 Protein export membrane protein; Region: SecD_SecF; cl14618 1249634003178 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1249634003179 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1249634003180 HlyD family secretion protein; Region: HlyD_3; pfam13437 1249634003181 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 1249634003182 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1249634003183 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1249634003184 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 1249634003185 hypothetical protein; Provisional; Region: PRK11038 1249634003186 Primosomal replication protein priB and priC; Region: priB_priC; pfam07445 1249634003187 hypothetical protein; Provisional; Region: PRK10527 1249634003188 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1249634003189 active site 1249634003190 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 1249634003191 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1249634003192 Walker A motif; other site 1249634003193 ATP binding site [chemical binding]; other site 1249634003194 Walker B motif; other site 1249634003195 arginine finger; other site 1249634003196 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1249634003197 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 1249634003198 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 1249634003199 contains DnaX ribosomal frameshifting element; D781_1058 1249634003200 hypothetical protein; Validated; Region: PRK00153 1249634003201 recombination protein RecR; Reviewed; Region: recR; PRK00076 1249634003202 RecR protein; Region: RecR; pfam02132 1249634003203 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1249634003204 putative active site [active] 1249634003205 putative metal-binding site [ion binding]; other site 1249634003206 tetramer interface [polypeptide binding]; other site 1249634003207 heat shock protein 90; Provisional; Region: PRK05218 1249634003208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1249634003209 ATP binding site [chemical binding]; other site 1249634003210 Mg2+ binding site [ion binding]; other site 1249634003211 G-X-G motif; other site 1249634003212 adenylate kinase; Reviewed; Region: adk; PRK00279 1249634003213 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1249634003214 AMP-binding site [chemical binding]; other site 1249634003215 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1249634003216 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1249634003217 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1249634003218 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1249634003219 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1249634003220 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1249634003221 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1249634003222 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1249634003223 ferrochelatase; Reviewed; Region: hemH; PRK00035 1249634003224 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1249634003225 C-terminal domain interface [polypeptide binding]; other site 1249634003226 active site 1249634003227 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1249634003228 active site 1249634003229 N-terminal domain interface [polypeptide binding]; other site 1249634003230 inosine/guanosine kinase; Provisional; Region: PRK15074 1249634003231 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1249634003232 substrate binding site [chemical binding]; other site 1249634003233 ATP binding site [chemical binding]; other site 1249634003234 putative cation:proton antiport protein; Provisional; Region: PRK10669 1249634003235 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 1249634003236 TrkA-N domain; Region: TrkA_N; pfam02254 1249634003237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634003238 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1249634003239 putative substrate translocation pore; other site 1249634003240 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 1249634003241 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 1249634003242 active site 1249634003243 metal binding site [ion binding]; metal-binding site 1249634003244 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1249634003245 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1249634003246 putative deacylase active site [active] 1249634003247 TraB family; Region: TraB; cl12050 1249634003248 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1249634003249 metal-binding site [ion binding] 1249634003250 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 1249634003251 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1249634003252 DNA binding residues [nucleotide binding] 1249634003253 dimer interface [polypeptide binding]; other site 1249634003254 copper binding site [ion binding]; other site 1249634003255 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1249634003256 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1249634003257 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1249634003258 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 1249634003259 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1249634003260 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1249634003261 S-adenosylmethionine binding site [chemical binding]; other site 1249634003262 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1249634003263 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1249634003264 oxidoreductase; Provisional; Region: PRK08017 1249634003265 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1249634003266 NADP binding site [chemical binding]; other site 1249634003267 active site 1249634003268 steroid binding site; other site 1249634003269 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1249634003270 active site 1249634003271 catalytic triad [active] 1249634003272 oxyanion hole [active] 1249634003273 switch loop; other site 1249634003274 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 1249634003275 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1249634003276 Walker A/P-loop; other site 1249634003277 ATP binding site [chemical binding]; other site 1249634003278 Q-loop/lid; other site 1249634003279 ABC transporter signature motif; other site 1249634003280 Walker B; other site 1249634003281 D-loop; other site 1249634003282 H-loop/switch region; other site 1249634003283 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1249634003284 FtsX-like permease family; Region: FtsX; pfam02687 1249634003285 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1249634003286 ATP-grasp domain; Region: ATP-grasp; pfam02222 1249634003287 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1249634003288 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1249634003289 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1249634003290 putative active site [active] 1249634003291 putative metal binding site [ion binding]; other site 1249634003292 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1249634003293 substrate binding site [chemical binding]; other site 1249634003294 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1249634003295 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1249634003296 active site 1249634003297 HIGH motif; other site 1249634003298 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1249634003299 KMSKS motif; other site 1249634003300 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1249634003301 tRNA binding surface [nucleotide binding]; other site 1249634003302 anticodon binding site; other site 1249634003303 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 1249634003304 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1249634003305 DNA binding site [nucleotide binding] 1249634003306 domain linker motif; other site 1249634003307 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1249634003308 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1249634003309 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1249634003310 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1249634003311 active site turn [active] 1249634003312 phosphorylation site [posttranslational modification] 1249634003313 ribosome-associated protein; Provisional; Region: PRK11507 1249634003314 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 1249634003315 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1249634003316 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1249634003317 homodimer interface [polypeptide binding]; other site 1249634003318 NADP binding site [chemical binding]; other site 1249634003319 substrate binding site [chemical binding]; other site 1249634003320 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 1249634003321 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 1249634003322 DNA polymerase III, theta subunit; Region: DNA_pol3_theta; cl11635 1249634003323 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634003324 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634003325 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1249634003326 putative effector binding pocket; other site 1249634003327 putative dimerization interface [polypeptide binding]; other site 1249634003328 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1249634003329 MASE1; Region: MASE1; cl17823 1249634003330 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1249634003331 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1249634003332 metal binding site [ion binding]; metal-binding site 1249634003333 active site 1249634003334 I-site; other site 1249634003335 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1249634003336 DNA-binding site [nucleotide binding]; DNA binding site 1249634003337 RNA-binding motif; other site 1249634003338 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1249634003339 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1249634003340 metal binding site [ion binding]; metal-binding site 1249634003341 dimer interface [polypeptide binding]; other site 1249634003342 contains cspA thermoregulator; D781_1104; IMG reference gene:2517282494 1249634003343 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1249634003344 DNA-binding site [nucleotide binding]; DNA binding site 1249634003345 RNA-binding motif; other site 1249634003346 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1249634003347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634003348 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1249634003349 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1249634003350 chromosome condensation membrane protein; Provisional; Region: PRK14196 1249634003351 twin arginine translocase protein A; Validated; Region: tatE; PRK01614 1249634003352 lipoyl synthase; Provisional; Region: PRK05481 1249634003353 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1249634003354 FeS/SAM binding site; other site 1249634003355 lipoate-protein ligase B; Provisional; Region: PRK14342 1249634003356 hypothetical protein; Provisional; Region: PRK04998 1249634003357 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 1249634003358 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1249634003359 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1249634003360 rare lipoprotein A; Provisional; Region: PRK10672 1249634003361 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1249634003362 Sporulation related domain; Region: SPOR; pfam05036 1249634003363 cell wall shape-determining protein; Provisional; Region: PRK10794 1249634003364 penicillin-binding protein 2; Provisional; Region: PRK10795 1249634003365 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1249634003366 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1249634003367 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1249634003368 ribosome-associated protein; Provisional; Region: PRK11538 1249634003369 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1249634003370 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1249634003371 active site 1249634003372 (T/H)XGH motif; other site 1249634003373 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1249634003374 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1249634003375 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 1249634003376 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1249634003377 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1249634003378 HIGH motif; other site 1249634003379 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1249634003380 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1249634003381 active site 1249634003382 KMSKS motif; other site 1249634003383 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1249634003384 tRNA binding surface [nucleotide binding]; other site 1249634003385 hypothetical protein; Provisional; Region: PRK11032 1249634003386 Predicted integral membrane metal-binding protein (DUF2296); Region: DUF2296; pfam10058 1249634003387 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 1249634003388 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1249634003389 active site 1249634003390 tetramer interface [polypeptide binding]; other site 1249634003391 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1249634003392 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1249634003393 Walker A/P-loop; other site 1249634003394 ATP binding site [chemical binding]; other site 1249634003395 Q-loop/lid; other site 1249634003396 ABC transporter signature motif; other site 1249634003397 Walker B; other site 1249634003398 D-loop; other site 1249634003399 H-loop/switch region; other site 1249634003400 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1249634003401 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634003402 dimer interface [polypeptide binding]; other site 1249634003403 conserved gate region; other site 1249634003404 putative PBP binding loops; other site 1249634003405 ABC-ATPase subunit interface; other site 1249634003406 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1249634003407 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634003408 dimer interface [polypeptide binding]; other site 1249634003409 conserved gate region; other site 1249634003410 putative PBP binding loops; other site 1249634003411 ABC-ATPase subunit interface; other site 1249634003412 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 1249634003413 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1249634003414 substrate binding pocket [chemical binding]; other site 1249634003415 membrane-bound complex binding site; other site 1249634003416 hinge residues; other site 1249634003417 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1249634003418 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1249634003419 putative active site [active] 1249634003420 catalytic triad [active] 1249634003421 putative dimer interface [polypeptide binding]; other site 1249634003422 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 1249634003423 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1249634003424 Transporter associated domain; Region: CorC_HlyC; smart01091 1249634003425 metal-binding heat shock protein; Provisional; Region: PRK00016 1249634003426 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1249634003427 PhoH-like protein; Region: PhoH; pfam02562 1249634003428 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1249634003429 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1249634003430 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1249634003431 FeS/SAM binding site; other site 1249634003432 TRAM domain; Region: TRAM; pfam01938 1249634003433 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1249634003434 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 1249634003435 asparagine synthetase B; Provisional; Region: asnB; PRK09431 1249634003436 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1249634003437 active site 1249634003438 dimer interface [polypeptide binding]; other site 1249634003439 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1249634003440 Ligand Binding Site [chemical binding]; other site 1249634003441 Molecular Tunnel; other site 1249634003442 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 1249634003443 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 1249634003444 putative active site [active] 1249634003445 UMP phosphatase; Provisional; Region: PRK10444 1249634003446 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1249634003447 active site 1249634003448 motif I; other site 1249634003449 motif II; other site 1249634003450 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1249634003451 motif II; other site 1249634003452 MarR family; Region: MarR; pfam01047 1249634003453 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1249634003454 ROK family; Region: ROK; pfam00480 1249634003455 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1249634003456 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1249634003457 active site 1249634003458 dimer interface [polypeptide binding]; other site 1249634003459 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1249634003460 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1249634003461 active site 1249634003462 trimer interface [polypeptide binding]; other site 1249634003463 allosteric site; other site 1249634003464 active site lid [active] 1249634003465 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1249634003466 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1249634003467 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 1249634003468 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1249634003469 active site turn [active] 1249634003470 phosphorylation site [posttranslational modification] 1249634003471 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1249634003472 HPr interaction site; other site 1249634003473 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1249634003474 active site 1249634003475 phosphorylation site [posttranslational modification] 1249634003476 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1249634003477 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1249634003478 active site 1249634003479 HIGH motif; other site 1249634003480 nucleotide binding site [chemical binding]; other site 1249634003481 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1249634003482 KMSKS motif; other site 1249634003483 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1249634003484 outer membrane porin, OprD family; Region: OprD; pfam03573 1249634003485 YbfN-like lipoprotein; Region: YbfN; pfam13982 1249634003486 Putative carbohydrate binding domain; Region: CHB_HEX; smart01081 1249634003487 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 1249634003488 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 1249634003489 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a...; Region: GH20_Sm-chitobiase-like; cd06569 1249634003490 active site 1249634003491 C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847 1249634003492 ferric uptake regulator; Provisional; Region: fur; PRK09462 1249634003493 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1249634003494 metal binding site 2 [ion binding]; metal-binding site 1249634003495 putative DNA binding helix; other site 1249634003496 metal binding site 1 [ion binding]; metal-binding site 1249634003497 dimer interface [polypeptide binding]; other site 1249634003498 structural Zn2+ binding site [ion binding]; other site 1249634003499 flavodoxin FldA; Validated; Region: PRK09267 1249634003500 LexA regulated protein; Provisional; Region: PRK11675 1249634003501 acyl-CoA esterase; Provisional; Region: PRK10673 1249634003502 PGAP1-like protein; Region: PGAP1; pfam07819 1249634003503 replication initiation regulator SeqA; Provisional; Region: PRK11187 1249634003504 phosphoglucomutase; Validated; Region: PRK07564 1249634003505 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1249634003506 active site 1249634003507 substrate binding site [chemical binding]; other site 1249634003508 metal binding site [ion binding]; metal-binding site 1249634003509 Predicted transcriptional regulators [Transcription]; Region: COG1695 1249634003510 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1249634003511 Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977 1249634003512 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1249634003513 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634003514 active site 1249634003515 phosphorylation site [posttranslational modification] 1249634003516 intermolecular recognition site; other site 1249634003517 dimerization interface [polypeptide binding]; other site 1249634003518 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1249634003519 DNA binding site [nucleotide binding] 1249634003520 sensor protein KdpD; Provisional; Region: PRK10490 1249634003521 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1249634003522 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1249634003523 Ligand Binding Site [chemical binding]; other site 1249634003524 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1249634003525 GAF domain; Region: GAF_3; pfam13492 1249634003526 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1249634003527 dimer interface [polypeptide binding]; other site 1249634003528 phosphorylation site [posttranslational modification] 1249634003529 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1249634003530 ATP binding site [chemical binding]; other site 1249634003531 Mg2+ binding site [ion binding]; other site 1249634003532 G-X-G motif; other site 1249634003533 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1249634003534 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1249634003535 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1249634003536 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1249634003537 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 1249634003538 Protein of unknown function (DUF523); Region: DUF523; pfam04463 1249634003539 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1249634003540 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 1249634003541 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 1249634003542 DNA photolyase; Region: DNA_photolyase; pfam00875 1249634003543 cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776 1249634003544 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1249634003545 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1249634003546 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1249634003547 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1249634003548 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1249634003549 LamB/YcsF family protein; Provisional; Region: PRK05406 1249634003550 Protein of unknown function (DUF969); Region: DUF969; pfam06149 1249634003551 Predicted membrane protein [Function unknown]; Region: COG3817 1249634003552 Protein of unknown function (DUF979); Region: DUF979; pfam06166 1249634003553 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1249634003554 putative substrate binding pocket [chemical binding]; other site 1249634003555 AC domain interface; other site 1249634003556 catalytic triad [active] 1249634003557 AB domain interface; other site 1249634003558 interchain disulfide; other site 1249634003559 endonuclease VIII; Provisional; Region: PRK10445 1249634003560 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 1249634003561 DNA binding site [nucleotide binding] 1249634003562 catalytic residue [active] 1249634003563 H2TH interface [polypeptide binding]; other site 1249634003564 putative catalytic residues [active] 1249634003565 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1249634003566 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1249634003567 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1249634003568 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1249634003569 dimer interface [polypeptide binding]; other site 1249634003570 active site 1249634003571 citrylCoA binding site [chemical binding]; other site 1249634003572 NADH binding [chemical binding]; other site 1249634003573 cationic pore residues; other site 1249634003574 oxalacetate/citrate binding site [chemical binding]; other site 1249634003575 coenzyme A binding site [chemical binding]; other site 1249634003576 catalytic triad [active] 1249634003577 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1249634003578 Iron-sulfur protein interface; other site 1249634003579 proximal quinone binding site [chemical binding]; other site 1249634003580 SdhD (CybS) interface [polypeptide binding]; other site 1249634003581 proximal heme binding site [chemical binding]; other site 1249634003582 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1249634003583 SdhC subunit interface [polypeptide binding]; other site 1249634003584 proximal heme binding site [chemical binding]; other site 1249634003585 cardiolipin binding site; other site 1249634003586 Iron-sulfur protein interface; other site 1249634003587 proximal quinone binding site [chemical binding]; other site 1249634003588 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 1249634003589 L-aspartate oxidase; Provisional; Region: PRK06175 1249634003590 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1249634003591 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1249634003592 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1249634003593 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1249634003594 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1249634003595 TPP-binding site [chemical binding]; other site 1249634003596 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1249634003597 dimer interface [polypeptide binding]; other site 1249634003598 PYR/PP interface [polypeptide binding]; other site 1249634003599 TPP binding site [chemical binding]; other site 1249634003600 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1249634003601 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1249634003602 E3 interaction surface; other site 1249634003603 lipoyl attachment site [posttranslational modification]; other site 1249634003604 e3 binding domain; Region: E3_binding; pfam02817 1249634003605 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1249634003606 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1249634003607 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1249634003608 CoA-ligase; Region: Ligase_CoA; pfam00549 1249634003609 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1249634003610 CoA binding domain; Region: CoA_binding; smart00881 1249634003611 CoA-ligase; Region: Ligase_CoA; pfam00549 1249634003612 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1249634003613 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1249634003614 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1249634003615 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1249634003616 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 1249634003617 hypothetical protein; Provisional; Region: PRK10588 1249634003618 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1249634003619 active site 1249634003620 colicin uptake protein TolQ; Provisional; Region: PRK10801 1249634003621 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1249634003622 colicin uptake protein TolR; Provisional; Region: PRK11024 1249634003623 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 1249634003624 TolA C-terminal; Region: TolA; pfam06519 1249634003625 translocation protein TolB; Provisional; Region: tolB; PRK03629 1249634003626 TolB amino-terminal domain; Region: TolB_N; pfam04052 1249634003627 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1249634003628 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1249634003629 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1249634003630 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 1249634003631 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1249634003632 ligand binding site [chemical binding]; other site 1249634003633 tol-pal system protein YbgF; Provisional; Region: PRK10803 1249634003634 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1249634003635 binding surface 1249634003636 TPR motif; other site 1249634003637 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1249634003638 Cupin; Region: Cupin_1; smart00835 1249634003639 Cupin; Region: Cupin_1; smart00835 1249634003640 quinolinate synthetase; Provisional; Region: PRK09375 1249634003641 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 1249634003642 Cation efflux family; Region: Cation_efflux; cl00316 1249634003643 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1249634003644 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1249634003645 substrate binding pocket [chemical binding]; other site 1249634003646 membrane-bound complex binding site; other site 1249634003647 hinge residues; other site 1249634003648 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1249634003649 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1249634003650 substrate binding pocket [chemical binding]; other site 1249634003651 membrane-bound complex binding site; other site 1249634003652 hinge residues; other site 1249634003653 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1249634003654 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1249634003655 dimer interface [polypeptide binding]; other site 1249634003656 phosphorylation site [posttranslational modification] 1249634003657 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1249634003658 ATP binding site [chemical binding]; other site 1249634003659 Mg2+ binding site [ion binding]; other site 1249634003660 G-X-G motif; other site 1249634003661 Response regulator receiver domain; Region: Response_reg; pfam00072 1249634003662 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634003663 active site 1249634003664 phosphorylation site [posttranslational modification] 1249634003665 intermolecular recognition site; other site 1249634003666 dimerization interface [polypeptide binding]; other site 1249634003667 Hpt domain; Region: Hpt; pfam01627 1249634003668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634003669 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1249634003670 active site 1249634003671 phosphorylation site [posttranslational modification] 1249634003672 intermolecular recognition site; other site 1249634003673 dimerization interface [polypeptide binding]; other site 1249634003674 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1249634003675 DNA binding residues [nucleotide binding] 1249634003676 dimerization interface [polypeptide binding]; other site 1249634003677 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1249634003678 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1249634003679 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1249634003680 catalytic core [active] 1249634003681 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1249634003682 psiF repeat; Region: PsiF_repeat; pfam07769 1249634003683 psiF repeat; Region: PsiF_repeat; pfam07769 1249634003684 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1249634003685 active site 1249634003686 catalytic residues [active] 1249634003687 galactokinase; Provisional; Region: PRK05101 1249634003688 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1249634003689 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1249634003690 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1249634003691 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 1249634003692 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1249634003693 dimer interface [polypeptide binding]; other site 1249634003694 active site 1249634003695 CAAX protease self-immunity; Region: Abi; pfam02517 1249634003696 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 1249634003697 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1249634003698 Walker A/P-loop; other site 1249634003699 ATP binding site [chemical binding]; other site 1249634003700 Q-loop/lid; other site 1249634003701 ABC transporter signature motif; other site 1249634003702 Walker B; other site 1249634003703 D-loop; other site 1249634003704 H-loop/switch region; other site 1249634003705 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1249634003706 Walker A/P-loop; other site 1249634003707 ATP binding site [chemical binding]; other site 1249634003708 Q-loop/lid; other site 1249634003709 ABC transporter signature motif; other site 1249634003710 Walker B; other site 1249634003711 D-loop; other site 1249634003712 H-loop/switch region; other site 1249634003713 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 1249634003714 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1249634003715 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1249634003716 TOBE domain; Region: TOBE; pfam03459 1249634003717 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 1249634003718 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 1249634003719 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1249634003720 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1249634003721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634003722 dimer interface [polypeptide binding]; other site 1249634003723 conserved gate region; other site 1249634003724 putative PBP binding loops; other site 1249634003725 ABC-ATPase subunit interface; other site 1249634003726 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 1249634003727 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1249634003728 Walker A/P-loop; other site 1249634003729 ATP binding site [chemical binding]; other site 1249634003730 Q-loop/lid; other site 1249634003731 ABC transporter signature motif; other site 1249634003732 Walker B; other site 1249634003733 D-loop; other site 1249634003734 H-loop/switch region; other site 1249634003735 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1249634003736 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 1249634003737 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1249634003738 active site 1249634003739 motif I; other site 1249634003740 motif II; other site 1249634003741 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1249634003742 6-phosphogluconolactonase; Provisional; Region: PRK11028 1249634003743 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 1249634003744 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1249634003745 substrate binding site [chemical binding]; other site 1249634003746 Uncharacterized conserved protein [Function unknown]; Region: COG3339 1249634003747 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 1249634003748 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1249634003749 inhibitor-cofactor binding pocket; inhibition site 1249634003750 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634003751 catalytic residue [active] 1249634003752 biotin synthase; Provisional; Region: PRK15108 1249634003753 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1249634003754 FeS/SAM binding site; other site 1249634003755 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1249634003756 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1249634003757 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1249634003758 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1249634003759 catalytic residue [active] 1249634003760 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1249634003761 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1249634003762 S-adenosylmethionine binding site [chemical binding]; other site 1249634003763 AAA domain; Region: AAA_26; pfam13500 1249634003764 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 1249634003765 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1249634003766 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1249634003767 Walker A/P-loop; other site 1249634003768 ATP binding site [chemical binding]; other site 1249634003769 Q-loop/lid; other site 1249634003770 ABC transporter signature motif; other site 1249634003771 Walker B; other site 1249634003772 D-loop; other site 1249634003773 H-loop/switch region; other site 1249634003774 excinuclease ABC subunit B; Provisional; Region: PRK05298 1249634003775 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1249634003776 ATP binding site [chemical binding]; other site 1249634003777 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1249634003778 nucleotide binding region [chemical binding]; other site 1249634003779 ATP-binding site [chemical binding]; other site 1249634003780 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1249634003781 UvrB/uvrC motif; Region: UVR; pfam02151 1249634003782 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 1249634003783 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1249634003784 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1249634003785 phosphate binding site [ion binding]; other site 1249634003786 putative substrate binding pocket [chemical binding]; other site 1249634003787 dimer interface [polypeptide binding]; other site 1249634003788 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1249634003789 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1249634003790 FeS/SAM binding site; other site 1249634003791 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1249634003792 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1249634003793 MPT binding site; other site 1249634003794 trimer interface [polypeptide binding]; other site 1249634003795 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1249634003796 trimer interface [polypeptide binding]; other site 1249634003797 dimer interface [polypeptide binding]; other site 1249634003798 putative active site [active] 1249634003799 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1249634003800 MoaE interaction surface [polypeptide binding]; other site 1249634003801 MoeB interaction surface [polypeptide binding]; other site 1249634003802 thiocarboxylated glycine; other site 1249634003803 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1249634003804 MoaE homodimer interface [polypeptide binding]; other site 1249634003805 MoaD interaction [polypeptide binding]; other site 1249634003806 active site residues [active] 1249634003807 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1249634003808 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1249634003809 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 1249634003810 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1249634003811 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1249634003812 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1249634003813 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1249634003814 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1249634003815 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1249634003816 Walker A/P-loop; other site 1249634003817 ATP binding site [chemical binding]; other site 1249634003818 Q-loop/lid; other site 1249634003819 ABC transporter signature motif; other site 1249634003820 Walker B; other site 1249634003821 D-loop; other site 1249634003822 H-loop/switch region; other site 1249634003823 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1249634003824 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1249634003825 Walker A/P-loop; other site 1249634003826 ATP binding site [chemical binding]; other site 1249634003827 Q-loop/lid; other site 1249634003828 ABC transporter signature motif; other site 1249634003829 Walker B; other site 1249634003830 D-loop; other site 1249634003831 H-loop/switch region; other site 1249634003832 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1249634003833 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1249634003834 HlyD family secretion protein; Region: HlyD_3; pfam13437 1249634003835 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 1249634003836 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1249634003837 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1249634003838 helicase 45; Provisional; Region: PTZ00424 1249634003839 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1249634003840 ATP binding site [chemical binding]; other site 1249634003841 Mg++ binding site [ion binding]; other site 1249634003842 motif III; other site 1249634003843 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1249634003844 nucleotide binding region [chemical binding]; other site 1249634003845 ATP-binding site [chemical binding]; other site 1249634003846 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 1249634003847 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1249634003848 FMN binding site [chemical binding]; other site 1249634003849 active site 1249634003850 catalytic residues [active] 1249634003851 substrate binding site [chemical binding]; other site 1249634003852 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 1249634003853 L-asparagine permease; Provisional; Region: PRK15049 1249634003854 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1249634003855 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1249634003856 dimerization interface [polypeptide binding]; other site 1249634003857 putative Zn2+ binding site [ion binding]; other site 1249634003858 putative DNA binding site [nucleotide binding]; other site 1249634003859 Predicted membrane protein [Function unknown]; Region: COG4125 1249634003860 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1249634003861 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1249634003862 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634003863 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634003864 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1249634003865 dimerization interface [polypeptide binding]; other site 1249634003866 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1249634003867 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1249634003868 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 1249634003869 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1249634003870 Protein of unknown function (DUF808); Region: DUF808; pfam05661 1249634003871 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1249634003872 EamA-like transporter family; Region: EamA; pfam00892 1249634003873 EamA-like transporter family; Region: EamA; pfam00892 1249634003874 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634003875 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634003876 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1249634003877 dimerization interface [polypeptide binding]; other site 1249634003878 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 1249634003879 lipoprotein, YaeC family; Region: TIGR00363 1249634003880 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 1249634003881 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1249634003882 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1249634003883 Coenzyme A binding pocket [chemical binding]; other site 1249634003884 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 1249634003885 putative trimer interface [polypeptide binding]; other site 1249634003886 putative active site [active] 1249634003887 putative substrate binding site [chemical binding]; other site 1249634003888 putative CoA binding site [chemical binding]; other site 1249634003889 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 1249634003890 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1249634003891 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1249634003892 inhibitor site; inhibition site 1249634003893 active site 1249634003894 dimer interface [polypeptide binding]; other site 1249634003895 catalytic residue [active] 1249634003896 D-lactate dehydrogenase; Provisional; Region: PRK11183 1249634003897 FAD binding domain; Region: FAD_binding_4; pfam01565 1249634003898 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 1249634003899 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1249634003900 active site 1249634003901 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 1249634003902 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1249634003903 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1249634003904 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1249634003905 Nitrate and nitrite sensing; Region: NIT; pfam08376 1249634003906 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1249634003907 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1249634003908 dimer interface [polypeptide binding]; other site 1249634003909 putative CheW interface [polypeptide binding]; other site 1249634003910 Isochorismatase family; Region: Isochorismatase; pfam00857 1249634003911 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1249634003912 catalytic triad [active] 1249634003913 conserved cis-peptide bond; other site 1249634003914 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 1249634003915 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1249634003916 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1249634003917 conserved cys residue [active] 1249634003918 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634003919 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1249634003920 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1249634003921 substrate binding pocket [chemical binding]; other site 1249634003922 membrane-bound complex binding site; other site 1249634003923 hinge residues; other site 1249634003924 putative aminotransferase; Provisional; Region: PRK12414 1249634003925 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1249634003926 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634003927 homodimer interface [polypeptide binding]; other site 1249634003928 catalytic residue [active] 1249634003929 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1249634003930 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634003931 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1249634003932 dimerization interface [polypeptide binding]; other site 1249634003933 substrate binding pocket [chemical binding]; other site 1249634003934 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1249634003935 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1249634003936 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1249634003937 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1249634003938 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 1249634003939 putative ligand binding residues [chemical binding]; other site 1249634003940 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1249634003941 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1249634003942 ABC-ATPase subunit interface; other site 1249634003943 dimer interface [polypeptide binding]; other site 1249634003944 putative PBP binding regions; other site 1249634003945 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1249634003946 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1249634003947 Walker A/P-loop; other site 1249634003948 ATP binding site [chemical binding]; other site 1249634003949 Q-loop/lid; other site 1249634003950 ABC transporter signature motif; other site 1249634003951 Walker B; other site 1249634003952 D-loop; other site 1249634003953 H-loop/switch region; other site 1249634003954 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1249634003955 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1249634003956 ParA-like protein; Provisional; Region: PHA02518 1249634003957 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1249634003958 P-loop; other site 1249634003959 Magnesium ion binding site [ion binding]; other site 1249634003960 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634003961 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634003962 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1249634003963 putative effector binding pocket; other site 1249634003964 putative dimerization interface [polypeptide binding]; other site 1249634003965 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1249634003966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634003967 putative substrate translocation pore; other site 1249634003968 Uncharacterized conserved protein [Function unknown]; Region: COG5470 1249634003969 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1249634003970 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1249634003971 DNA-binding site [nucleotide binding]; DNA binding site 1249634003972 FCD domain; Region: FCD; pfam07729 1249634003973 Amino acid synthesis; Region: AA_synth; pfam06684 1249634003974 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1249634003975 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1249634003976 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1249634003977 TAP-like protein; Region: Abhydrolase_4; pfam08386 1249634003978 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1249634003979 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1249634003980 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1249634003981 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1249634003982 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 1249634003983 NAD(P) binding site [chemical binding]; other site 1249634003984 catalytic residues [active] 1249634003985 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1249634003986 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1249634003987 Na binding site [ion binding]; other site 1249634003988 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 1249634003989 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 1249634003990 putative N- and C-terminal domain interface [polypeptide binding]; other site 1249634003991 putative active site [active] 1249634003992 putative MgATP binding site [chemical binding]; other site 1249634003993 catalytic site [active] 1249634003994 metal binding site [ion binding]; metal-binding site 1249634003995 putative carbohydrate binding site [chemical binding]; other site 1249634003996 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 1249634003997 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1249634003998 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1249634003999 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1249634004000 Coenzyme A binding pocket [chemical binding]; other site 1249634004001 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 1249634004002 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1249634004003 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1249634004004 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1249634004005 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1249634004006 Coenzyme A binding pocket [chemical binding]; other site 1249634004007 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1249634004008 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1249634004009 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1249634004010 D-galactonate transporter; Region: 2A0114; TIGR00893 1249634004011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634004012 putative substrate translocation pore; other site 1249634004013 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1249634004014 DNA-binding site [nucleotide binding]; DNA binding site 1249634004015 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1249634004016 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1249634004017 DNA-binding site [nucleotide binding]; DNA binding site 1249634004018 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1249634004019 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1249634004020 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1249634004021 putative NAD(P) binding site [chemical binding]; other site 1249634004022 catalytic Zn binding site [ion binding]; other site 1249634004023 structural Zn binding site [ion binding]; other site 1249634004024 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1249634004025 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1249634004026 Walker A/P-loop; other site 1249634004027 ATP binding site [chemical binding]; other site 1249634004028 Q-loop/lid; other site 1249634004029 ABC transporter signature motif; other site 1249634004030 Walker B; other site 1249634004031 D-loop; other site 1249634004032 H-loop/switch region; other site 1249634004033 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 1249634004034 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1249634004035 substrate binding pocket [chemical binding]; other site 1249634004036 membrane-bound complex binding site; other site 1249634004037 hinge residues; other site 1249634004038 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1249634004039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634004040 dimer interface [polypeptide binding]; other site 1249634004041 conserved gate region; other site 1249634004042 putative PBP binding loops; other site 1249634004043 ABC-ATPase subunit interface; other site 1249634004044 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1249634004045 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 1249634004046 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1249634004047 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1249634004048 Bacterial SH3 domain; Region: SH3_4; pfam06347 1249634004049 allophanate hydrolase; Provisional; Region: PRK08186 1249634004050 Amidase; Region: Amidase; cl11426 1249634004051 urea carboxylase; Region: urea_carbox; TIGR02712 1249634004052 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1249634004053 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1249634004054 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1249634004055 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1249634004056 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1249634004057 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1249634004058 carboxyltransferase (CT) interaction site; other site 1249634004059 biotinylation site [posttranslational modification]; other site 1249634004060 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1249634004061 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1249634004062 DNA-binding site [nucleotide binding]; DNA binding site 1249634004063 FCD domain; Region: FCD; pfam07729 1249634004064 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1249634004065 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1249634004066 putative ligand binding site [chemical binding]; other site 1249634004067 HEAT repeats; Region: HEAT_2; pfam13646 1249634004068 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1249634004069 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1249634004070 TM-ABC transporter signature motif; other site 1249634004071 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1249634004072 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1249634004073 TM-ABC transporter signature motif; other site 1249634004074 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1249634004075 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1249634004076 Walker A/P-loop; other site 1249634004077 ATP binding site [chemical binding]; other site 1249634004078 Q-loop/lid; other site 1249634004079 ABC transporter signature motif; other site 1249634004080 Walker B; other site 1249634004081 D-loop; other site 1249634004082 H-loop/switch region; other site 1249634004083 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1249634004084 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1249634004085 Walker A/P-loop; other site 1249634004086 ATP binding site [chemical binding]; other site 1249634004087 Q-loop/lid; other site 1249634004088 ABC transporter signature motif; other site 1249634004089 Walker B; other site 1249634004090 D-loop; other site 1249634004091 H-loop/switch region; other site 1249634004092 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 1249634004093 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1249634004094 active site residue [active] 1249634004095 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1249634004096 active site residue [active] 1249634004097 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 1249634004098 nudix motif; other site 1249634004099 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1249634004100 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1249634004101 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1249634004102 active site 1249634004103 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 1249634004104 Isochorismatase family; Region: Isochorismatase; pfam00857 1249634004105 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1249634004106 catalytic triad [active] 1249634004107 dimer interface [polypeptide binding]; other site 1249634004108 conserved cis-peptide bond; other site 1249634004109 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634004110 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634004111 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1249634004112 dimerization interface [polypeptide binding]; other site 1249634004113 benzoate transport; Region: 2A0115; TIGR00895 1249634004114 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1249634004115 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 1249634004116 catalytic Zn binding site [ion binding]; other site 1249634004117 NAD binding site [chemical binding]; other site 1249634004118 structural Zn binding site [ion binding]; other site 1249634004119 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1249634004120 putative di-iron ligands [ion binding]; other site 1249634004121 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1249634004122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634004123 dimer interface [polypeptide binding]; other site 1249634004124 conserved gate region; other site 1249634004125 ABC-ATPase subunit interface; other site 1249634004126 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1249634004127 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1249634004128 Walker A/P-loop; other site 1249634004129 ATP binding site [chemical binding]; other site 1249634004130 Q-loop/lid; other site 1249634004131 ABC transporter signature motif; other site 1249634004132 Walker B; other site 1249634004133 D-loop; other site 1249634004134 H-loop/switch region; other site 1249634004135 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1249634004136 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634004137 dimer interface [polypeptide binding]; other site 1249634004138 conserved gate region; other site 1249634004139 putative PBP binding loops; other site 1249634004140 ABC-ATPase subunit interface; other site 1249634004141 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1249634004142 membrane-bound complex binding site; other site 1249634004143 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 1249634004144 Predicted transcriptional regulator [Transcription]; Region: COG2345 1249634004145 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1249634004146 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1249634004147 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634004148 AzlC protein; Region: AzlC; cl00570 1249634004149 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 1249634004150 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1249634004151 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1249634004152 trimer interface [polypeptide binding]; other site 1249634004153 eyelet of channel; other site 1249634004154 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1249634004155 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1249634004156 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1249634004157 dimer interface [polypeptide binding]; other site 1249634004158 substrate binding pocket (H-site) [chemical binding]; other site 1249634004159 N-terminal domain interface [polypeptide binding]; other site 1249634004160 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 1249634004161 DEAD_2; Region: DEAD_2; pfam06733 1249634004162 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1249634004163 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1249634004164 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1249634004165 putative DNA binding site [nucleotide binding]; other site 1249634004166 putative Zn2+ binding site [ion binding]; other site 1249634004167 AsnC family; Region: AsnC_trans_reg; pfam01037 1249634004168 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1249634004169 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1249634004170 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 1249634004171 putative active site [active] 1249634004172 putative nucleic acid binding site [nucleotide binding]; other site 1249634004173 Transposase; Region: HTH_Tnp_1; cl17663 1249634004174 HTH-like domain; Region: HTH_21; pfam13276 1249634004175 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1249634004176 DNA-binding interface [nucleotide binding]; DNA binding site 1249634004177 IS2 transposase TnpB; Reviewed; Region: PRK09409 1249634004178 HTH-like domain; Region: HTH_21; pfam13276 1249634004179 Integrase core domain; Region: rve; pfam00665 1249634004180 Integrase core domain; Region: rve_3; pfam13683 1249634004181 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1249634004182 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1249634004183 Walker A motif; other site 1249634004184 ATP binding site [chemical binding]; other site 1249634004185 Walker B motif; other site 1249634004186 arginine finger; other site 1249634004187 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 1249634004188 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1249634004189 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1249634004190 active site 1249634004191 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634004192 putative substrate translocation pore; other site 1249634004193 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1249634004194 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1249634004195 NAD(P) binding site [chemical binding]; other site 1249634004196 active site 1249634004197 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634004198 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634004199 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1249634004200 dimerization interface [polypeptide binding]; other site 1249634004201 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1249634004202 active site 1249634004203 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1249634004204 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634004205 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1249634004206 dimerization interface [polypeptide binding]; other site 1249634004207 substrate binding pocket [chemical binding]; other site 1249634004208 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1249634004209 EamA-like transporter family; Region: EamA; cl17759 1249634004210 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1249634004211 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1249634004212 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1249634004213 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1249634004214 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1249634004215 Coenzyme A binding pocket [chemical binding]; other site 1249634004216 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1249634004217 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 1249634004218 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1249634004219 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1249634004220 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1249634004221 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1249634004222 active site 1249634004223 motif I; other site 1249634004224 motif II; other site 1249634004225 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1249634004226 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1249634004227 Zn2+ binding site [ion binding]; other site 1249634004228 Mg2+ binding site [ion binding]; other site 1249634004229 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1249634004230 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1249634004231 conserved cys residue [active] 1249634004232 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634004233 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634004234 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1249634004235 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1249634004236 EthD domain; Region: EthD; cl17553 1249634004237 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-2; cd12809 1249634004238 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1249634004239 catalytic site [active] 1249634004240 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634004241 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634004242 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1249634004243 putative effector binding pocket; other site 1249634004244 putative dimerization interface [polypeptide binding]; other site 1249634004245 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1249634004246 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1249634004247 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1249634004248 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634004249 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634004250 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1249634004251 dimerization interface [polypeptide binding]; other site 1249634004252 SnoaL-like domain; Region: SnoaL_2; pfam12680 1249634004253 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1249634004254 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1249634004255 TAP-like protein; Region: Abhydrolase_4; pfam08386 1249634004256 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634004257 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634004258 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1249634004259 putative effector binding pocket; other site 1249634004260 dimerization interface [polypeptide binding]; other site 1249634004261 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1249634004262 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 1249634004263 NAD(P) binding site [chemical binding]; other site 1249634004264 active site 1249634004265 methionine synthase; Provisional; Region: PRK01207 1249634004266 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1249634004267 substrate binding site [chemical binding]; other site 1249634004268 THF binding site; other site 1249634004269 zinc-binding site [ion binding]; other site 1249634004270 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 1249634004271 glycosyl transferase family protein; Provisional; Region: PRK08136 1249634004272 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1249634004273 Peptidase M3-like family, a zincin metallopeptidase, includes M3 and M32 families; Region: M3_like; cd06258 1249634004274 active site 1249634004275 Zn binding site [ion binding]; other site 1249634004276 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1249634004277 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 1249634004278 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1249634004279 S-adenosylmethionine binding site [chemical binding]; other site 1249634004280 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1249634004281 PAS domain; Region: PAS_9; pfam13426 1249634004282 putative active site [active] 1249634004283 heme pocket [chemical binding]; other site 1249634004284 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1249634004285 PAS domain; Region: PAS_9; pfam13426 1249634004286 putative active site [active] 1249634004287 heme pocket [chemical binding]; other site 1249634004288 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1249634004289 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1249634004290 dimer interface [polypeptide binding]; other site 1249634004291 putative CheW interface [polypeptide binding]; other site 1249634004292 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1249634004293 FMN binding site [chemical binding]; other site 1249634004294 substrate binding site [chemical binding]; other site 1249634004295 putative catalytic residue [active] 1249634004296 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634004297 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634004298 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1249634004299 dimerization interface [polypeptide binding]; other site 1249634004300 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 1249634004301 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1249634004302 Walker A/P-loop; other site 1249634004303 ATP binding site [chemical binding]; other site 1249634004304 Q-loop/lid; other site 1249634004305 ABC transporter signature motif; other site 1249634004306 Walker B; other site 1249634004307 D-loop; other site 1249634004308 H-loop/switch region; other site 1249634004309 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1249634004310 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634004311 dimer interface [polypeptide binding]; other site 1249634004312 conserved gate region; other site 1249634004313 putative PBP binding loops; other site 1249634004314 ABC-ATPase subunit interface; other site 1249634004315 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1249634004316 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1249634004317 substrate binding pocket [chemical binding]; other site 1249634004318 membrane-bound complex binding site; other site 1249634004319 hinge residues; other site 1249634004320 hypothetical protein; Provisional; Region: PRK11019 1249634004321 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1249634004322 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1249634004323 dimerization interface [polypeptide binding]; other site 1249634004324 DPS ferroxidase diiron center [ion binding]; other site 1249634004325 ion pore; other site 1249634004326 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 1249634004327 active site 1249634004328 catalytic residues [active] 1249634004329 Domain of unknown function (DUF386); Region: DUF386; cl01047 1249634004330 threonine and homoserine efflux system; Provisional; Region: PRK10532 1249634004331 EamA-like transporter family; Region: EamA; pfam00892 1249634004332 outer membrane protein X; Provisional; Region: ompX; PRK09408 1249634004333 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1249634004334 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1249634004335 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1249634004336 putative transporter; Provisional; Region: PRK09821 1249634004337 GntP family permease; Region: GntP_permease; pfam02447 1249634004338 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 1249634004339 putative aldolase; Validated; Region: PRK08130 1249634004340 active site 1249634004341 intersubunit interface [polypeptide binding]; other site 1249634004342 Zn2+ binding site [ion binding]; other site 1249634004343 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1249634004344 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1249634004345 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1249634004346 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1249634004347 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1249634004348 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1249634004349 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1249634004350 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1249634004351 DNA binding site [nucleotide binding] 1249634004352 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1249634004353 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1249634004354 DNA binding residues [nucleotide binding] 1249634004355 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1249634004356 putative chaperone protein EcpD; Provisional; Region: PRK09926 1249634004357 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1249634004358 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1249634004359 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1249634004360 PapC N-terminal domain; Region: PapC_N; pfam13954 1249634004361 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1249634004362 PapC C-terminal domain; Region: PapC_C; pfam13953 1249634004363 Fimbrial protein; Region: Fimbrial; cl01416 1249634004364 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1249634004365 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1249634004366 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1249634004367 choline transport protein BetT; Provisional; Region: PRK09928 1249634004368 transcriptional regulator BetI; Validated; Region: PRK00767 1249634004369 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1249634004370 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1249634004371 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 1249634004372 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 1249634004373 tetrameric interface [polypeptide binding]; other site 1249634004374 NAD binding site [chemical binding]; other site 1249634004375 catalytic residues [active] 1249634004376 choline dehydrogenase; Validated; Region: PRK02106 1249634004377 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1249634004378 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1249634004379 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1249634004380 active site 1249634004381 FMN binding site [chemical binding]; other site 1249634004382 substrate binding site [chemical binding]; other site 1249634004383 3Fe-4S cluster binding site [ion binding]; other site 1249634004384 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 1249634004385 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 1249634004386 DNA binding residues [nucleotide binding] 1249634004387 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1249634004388 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1249634004389 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1249634004390 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1249634004391 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1249634004392 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1249634004393 PapC N-terminal domain; Region: PapC_N; pfam13954 1249634004394 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1249634004395 PapC C-terminal domain; Region: PapC_C; pfam13953 1249634004396 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1249634004397 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1249634004398 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1249634004399 Helix-turn-helix domain; Region: HTH_28; pfam13518 1249634004400 putative transposase OrfB; Reviewed; Region: PHA02517 1249634004401 Integrase core domain; Region: rve; pfam00665 1249634004402 Integrase core domain; Region: rve_3; pfam13683 1249634004403 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1249634004404 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634004405 malate:quinone oxidoreductase; Validated; Region: PRK05257 1249634004406 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1249634004407 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1249634004408 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1249634004409 C-terminal domain interface [polypeptide binding]; other site 1249634004410 GSH binding site (G-site) [chemical binding]; other site 1249634004411 dimer interface [polypeptide binding]; other site 1249634004412 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 1249634004413 dimer interface [polypeptide binding]; other site 1249634004414 N-terminal domain interface [polypeptide binding]; other site 1249634004415 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1249634004416 dimerization interface [polypeptide binding]; other site 1249634004417 putative DNA binding site [nucleotide binding]; other site 1249634004418 putative Zn2+ binding site [ion binding]; other site 1249634004419 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1249634004420 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 1249634004421 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 1249634004422 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 1249634004423 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 1249634004424 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 1249634004425 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 1249634004426 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 1249634004427 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1249634004428 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1249634004429 Walker A/P-loop; other site 1249634004430 ATP binding site [chemical binding]; other site 1249634004431 Q-loop/lid; other site 1249634004432 ABC transporter signature motif; other site 1249634004433 Walker B; other site 1249634004434 D-loop; other site 1249634004435 H-loop/switch region; other site 1249634004436 ABC transporter; Region: ABC_tran_2; pfam12848 1249634004437 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1249634004438 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1249634004439 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1249634004440 ATP binding site [chemical binding]; other site 1249634004441 substrate interface [chemical binding]; other site 1249634004442 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 1249634004443 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1249634004444 dimer interface [polypeptide binding]; other site 1249634004445 putative functional site; other site 1249634004446 putative MPT binding site; other site 1249634004447 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 1249634004448 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 1249634004449 catalytic nucleophile [active] 1249634004450 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1249634004451 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1249634004452 Walker A/P-loop; other site 1249634004453 ATP binding site [chemical binding]; other site 1249634004454 Q-loop/lid; other site 1249634004455 ABC transporter signature motif; other site 1249634004456 Walker B; other site 1249634004457 D-loop; other site 1249634004458 H-loop/switch region; other site 1249634004459 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1249634004460 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1249634004461 Walker A/P-loop; other site 1249634004462 ATP binding site [chemical binding]; other site 1249634004463 Q-loop/lid; other site 1249634004464 ABC transporter signature motif; other site 1249634004465 Walker B; other site 1249634004466 D-loop; other site 1249634004467 H-loop/switch region; other site 1249634004468 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1249634004469 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 1249634004470 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 1249634004471 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 1249634004472 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634004473 dimer interface [polypeptide binding]; other site 1249634004474 conserved gate region; other site 1249634004475 putative PBP binding loops; other site 1249634004476 ABC-ATPase subunit interface; other site 1249634004477 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 1249634004478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634004479 dimer interface [polypeptide binding]; other site 1249634004480 conserved gate region; other site 1249634004481 putative PBP binding loops; other site 1249634004482 ABC-ATPase subunit interface; other site 1249634004483 S-formylglutathione hydrolase; Region: PLN02442 1249634004484 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1249634004485 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1249634004486 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1249634004487 substrate binding site [chemical binding]; other site 1249634004488 catalytic Zn binding site [ion binding]; other site 1249634004489 NAD binding site [chemical binding]; other site 1249634004490 structural Zn binding site [ion binding]; other site 1249634004491 dimer interface [polypeptide binding]; other site 1249634004492 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634004493 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634004494 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1249634004495 putative dimerization interface [polypeptide binding]; other site 1249634004496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634004497 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1249634004498 putative substrate translocation pore; other site 1249634004499 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1249634004500 active site 1249634004501 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1249634004502 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1249634004503 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 1249634004504 DctM-like transporters; Region: DctM; pfam06808 1249634004505 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1249634004506 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1249634004507 DNA-binding site [nucleotide binding]; DNA binding site 1249634004508 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1249634004509 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1249634004510 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1249634004511 Predicted membrane protein [Function unknown]; Region: COG2311 1249634004512 hypothetical protein; Provisional; Region: PRK10835 1249634004513 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1249634004514 putative active site [active] 1249634004515 malate dehydrogenase; Provisional; Region: PRK13529 1249634004516 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1249634004517 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1249634004518 NAD(P) binding site [chemical binding]; other site 1249634004519 cytidine deaminase; Provisional; Region: PRK09027 1249634004520 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1249634004521 active site 1249634004522 catalytic motif [active] 1249634004523 Zn binding site [ion binding]; other site 1249634004524 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1249634004525 active site 1249634004526 catalytic motif [active] 1249634004527 Zn binding site [ion binding]; other site 1249634004528 hypothetical protein; Provisional; Region: PRK10711 1249634004529 hypothetical protein; Provisional; Region: PRK01821 1249634004530 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634004531 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1249634004532 putative substrate translocation pore; other site 1249634004533 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1249634004534 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1249634004535 active site 1249634004536 HIGH motif; other site 1249634004537 KMSKS motif; other site 1249634004538 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1249634004539 tRNA binding surface [nucleotide binding]; other site 1249634004540 anticodon binding site; other site 1249634004541 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1249634004542 dimer interface [polypeptide binding]; other site 1249634004543 putative tRNA-binding site [nucleotide binding]; other site 1249634004544 antiporter inner membrane protein; Provisional; Region: PRK11670 1249634004545 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1249634004546 Walker A motif; other site 1249634004547 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1249634004548 active site 1249634004549 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1249634004550 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1249634004551 ATP-binding site [chemical binding]; other site 1249634004552 Sugar specificity; other site 1249634004553 Pyrimidine base specificity; other site 1249634004554 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1249634004555 trimer interface [polypeptide binding]; other site 1249634004556 active site 1249634004557 putative assembly protein; Provisional; Region: PRK10833 1249634004558 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1249634004559 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 1249634004560 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1249634004561 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1249634004562 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1249634004563 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1249634004564 Transporter associated domain; Region: CorC_HlyC; smart01091 1249634004565 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1249634004566 active site 1249634004567 tetramer interface; other site 1249634004568 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1249634004569 active site 1249634004570 tetramer interface; other site 1249634004571 polysaccharide export protein Wza; Provisional; Region: PRK15078 1249634004572 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1249634004573 SLBB domain; Region: SLBB; pfam10531 1249634004574 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1249634004575 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1249634004576 active site 1249634004577 tyrosine kinase; Provisional; Region: PRK11519 1249634004578 Chain length determinant protein; Region: Wzz; pfam02706 1249634004579 Chain length determinant protein; Region: Wzz; cl15801 1249634004580 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1249634004581 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1249634004582 P loop; other site 1249634004583 Nucleotide binding site [chemical binding]; other site 1249634004584 DTAP/Switch II; other site 1249634004585 Switch I; other site 1249634004586 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1249634004587 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1249634004588 active site 1249634004589 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 1249634004590 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1249634004591 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 1249634004592 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1249634004593 NAD binding site [chemical binding]; other site 1249634004594 substrate binding site [chemical binding]; other site 1249634004595 homodimer interface [polypeptide binding]; other site 1249634004596 active site 1249634004597 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1249634004598 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1249634004599 substrate binding site; other site 1249634004600 tetramer interface; other site 1249634004601 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1249634004602 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1249634004603 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1249634004604 NADP binding site [chemical binding]; other site 1249634004605 active site 1249634004606 putative substrate binding site [chemical binding]; other site 1249634004607 putative glycosyl transferase; Provisional; Region: PRK10018 1249634004608 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1249634004609 active site 1249634004610 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1249634004611 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1249634004612 active site 1249634004613 colanic acid exporter; Provisional; Region: PRK10459 1249634004614 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1249634004615 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1249634004616 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1249634004617 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1249634004618 active site 1249634004619 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 1249634004620 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 1249634004621 Walker A/P-loop; other site 1249634004622 ATP binding site [chemical binding]; other site 1249634004623 Q-loop/lid; other site 1249634004624 ABC transporter signature motif; other site 1249634004625 Walker B; other site 1249634004626 D-loop; other site 1249634004627 H-loop/switch region; other site 1249634004628 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1249634004629 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1249634004630 HlyD family secretion protein; Region: HlyD_3; pfam13437 1249634004631 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1249634004632 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1249634004633 UDP-glucose 4-epimerase; Region: PLN02240 1249634004634 NAD binding site [chemical binding]; other site 1249634004635 homodimer interface [polypeptide binding]; other site 1249634004636 active site 1249634004637 substrate binding site [chemical binding]; other site 1249634004638 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1249634004639 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1249634004640 putative ADP-binding pocket [chemical binding]; other site 1249634004641 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1249634004642 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1249634004643 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1249634004644 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1249634004645 active site 1249634004646 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1249634004647 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1249634004648 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1249634004649 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1249634004650 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1249634004651 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1249634004652 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1249634004653 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1249634004654 metal binding site [ion binding]; metal-binding site 1249634004655 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1249634004656 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1249634004657 substrate binding site [chemical binding]; other site 1249634004658 glutamase interaction surface [polypeptide binding]; other site 1249634004659 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1249634004660 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1249634004661 catalytic residues [active] 1249634004662 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 1249634004663 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1249634004664 putative active site [active] 1249634004665 oxyanion strand; other site 1249634004666 catalytic triad [active] 1249634004667 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 1249634004668 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1249634004669 active site 1249634004670 motif I; other site 1249634004671 motif II; other site 1249634004672 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1249634004673 putative active site pocket [active] 1249634004674 4-fold oligomerization interface [polypeptide binding]; other site 1249634004675 metal binding residues [ion binding]; metal-binding site 1249634004676 3-fold/trimer interface [polypeptide binding]; other site 1249634004677 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 1249634004678 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1249634004679 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634004680 homodimer interface [polypeptide binding]; other site 1249634004681 catalytic residue [active] 1249634004682 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1249634004683 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1249634004684 NAD binding site [chemical binding]; other site 1249634004685 dimerization interface [polypeptide binding]; other site 1249634004686 product binding site; other site 1249634004687 substrate binding site [chemical binding]; other site 1249634004688 zinc binding site [ion binding]; other site 1249634004689 catalytic residues [active] 1249634004690 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1249634004691 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1249634004692 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1249634004693 Histidine operon leader; D781_1524; IMG reference gene:2517282914 1249634004694 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1249634004695 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1249634004696 NAD(P) binding site [chemical binding]; other site 1249634004697 active site 1249634004698 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1249634004699 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1249634004700 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1249634004701 FeS/SAM binding site; other site 1249634004702 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1249634004703 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1249634004704 Bacterial transcriptional regulator; Region: IclR; pfam01614 1249634004705 hypothetical protein; Validated; Region: PRK06201 1249634004706 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 1249634004707 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1249634004708 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 1249634004709 ligand binding site [chemical binding]; other site 1249634004710 NAD binding site [chemical binding]; other site 1249634004711 dimerization interface [polypeptide binding]; other site 1249634004712 catalytic site [active] 1249634004713 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1249634004714 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1249634004715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634004716 putative substrate translocation pore; other site 1249634004717 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1249634004718 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 1249634004719 active site 1249634004720 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634004721 putative substrate translocation pore; other site 1249634004722 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1249634004723 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1249634004724 oligomer interface [polypeptide binding]; other site 1249634004725 metal binding site [ion binding]; metal-binding site 1249634004726 metal binding site [ion binding]; metal-binding site 1249634004727 putative Cl binding site [ion binding]; other site 1249634004728 basic sphincter; other site 1249634004729 hydrophobic gate; other site 1249634004730 periplasmic entrance; other site 1249634004731 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1249634004732 Coenzyme A binding pocket [chemical binding]; other site 1249634004733 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1249634004734 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1249634004735 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1249634004736 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1249634004737 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1249634004738 motif II; other site 1249634004739 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 1249634004740 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1249634004741 homodimer interface [polypeptide binding]; other site 1249634004742 substrate-cofactor binding pocket; other site 1249634004743 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634004744 catalytic residue [active] 1249634004745 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1249634004746 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1249634004747 dimer interface [polypeptide binding]; other site 1249634004748 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634004749 catalytic residue [active] 1249634004750 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1249634004751 FOG: CBS domain [General function prediction only]; Region: COG0517 1249634004752 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 1249634004753 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1249634004754 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1249634004755 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1249634004756 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1249634004757 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1249634004758 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1249634004759 serine transporter; Region: stp; TIGR00814 1249634004760 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 1249634004761 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1249634004762 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1249634004763 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1249634004764 intersubunit interface [polypeptide binding]; other site 1249634004765 active site 1249634004766 catalytic residue [active] 1249634004767 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1249634004768 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1249634004769 active site 1249634004770 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 1249634004771 active site 1249634004772 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 1249634004773 secondary substrate binding site; other site 1249634004774 primary substrate binding site; other site 1249634004775 inhibition loop; other site 1249634004776 dimerization interface [polypeptide binding]; other site 1249634004777 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1249634004778 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1249634004779 active site 1249634004780 metal binding site [ion binding]; metal-binding site 1249634004781 nudix motif; other site 1249634004782 UbiA prenyltransferase family; Region: UbiA; pfam01040 1249634004783 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1249634004784 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1249634004785 UbiA prenyltransferase family; Region: UbiA; pfam01040 1249634004786 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1249634004787 Domain of unknown function (DUF4354); Region: DUF4354; pfam14263 1249634004788 putative transporter; Provisional; Region: PRK04972 1249634004789 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1249634004790 TrkA-C domain; Region: TrkA_C; pfam02080 1249634004791 TrkA-C domain; Region: TrkA_C; pfam02080 1249634004792 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1249634004793 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 1249634004794 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 1249634004795 GSH binding site [chemical binding]; other site 1249634004796 catalytic residues [active] 1249634004797 hypothetical protein; Provisional; Region: PRK10591 1249634004798 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1249634004799 RimK-like ATP-grasp domain; Region: RimK; pfam08443 1249634004800 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1249634004801 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 1249634004802 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 1249634004803 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1249634004804 S-adenosylmethionine binding site [chemical binding]; other site 1249634004805 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1249634004806 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1249634004807 substrate binding pocket [chemical binding]; other site 1249634004808 membrane-bound complex binding site; other site 1249634004809 hinge residues; other site 1249634004810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634004811 dimer interface [polypeptide binding]; other site 1249634004812 conserved gate region; other site 1249634004813 putative PBP binding loops; other site 1249634004814 ABC-ATPase subunit interface; other site 1249634004815 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1249634004816 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634004817 dimer interface [polypeptide binding]; other site 1249634004818 conserved gate region; other site 1249634004819 putative PBP binding loops; other site 1249634004820 ABC-ATPase subunit interface; other site 1249634004821 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1249634004822 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1249634004823 substrate binding pocket [chemical binding]; other site 1249634004824 membrane-bound complex binding site; other site 1249634004825 hinge residues; other site 1249634004826 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 1249634004827 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1249634004828 Walker A/P-loop; other site 1249634004829 ATP binding site [chemical binding]; other site 1249634004830 Q-loop/lid; other site 1249634004831 ABC transporter signature motif; other site 1249634004832 Walker B; other site 1249634004833 D-loop; other site 1249634004834 H-loop/switch region; other site 1249634004835 putative lipoprotein; Provisional; Region: PRK10533 1249634004836 hypothetical protein; Provisional; Region: PRK02877 1249634004837 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1249634004838 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1249634004839 amidase catalytic site [active] 1249634004840 Zn binding residues [ion binding]; other site 1249634004841 substrate binding site [chemical binding]; other site 1249634004842 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1249634004843 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1249634004844 NAD(P) binding site [chemical binding]; other site 1249634004845 active site 1249634004846 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1249634004847 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 1249634004848 putative NAD(P) binding site [chemical binding]; other site 1249634004849 putative active site [active] 1249634004850 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1249634004851 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 1249634004852 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1249634004853 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1249634004854 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1249634004855 putative active site [active] 1249634004856 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1249634004857 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1249634004858 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1249634004859 active site turn [active] 1249634004860 phosphorylation site [posttranslational modification] 1249634004861 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1249634004862 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1249634004863 putative active site cavity [active] 1249634004864 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1249634004865 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1249634004866 tetramer interface [polypeptide binding]; other site 1249634004867 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634004868 catalytic residue [active] 1249634004869 pyruvate dehydrogenase; Provisional; Region: PRK09124 1249634004870 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1249634004871 PYR/PP interface [polypeptide binding]; other site 1249634004872 dimer interface [polypeptide binding]; other site 1249634004873 tetramer interface [polypeptide binding]; other site 1249634004874 TPP binding site [chemical binding]; other site 1249634004875 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1249634004876 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1249634004877 TPP-binding site [chemical binding]; other site 1249634004878 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 1249634004879 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1249634004880 FAD binding pocket [chemical binding]; other site 1249634004881 FAD binding motif [chemical binding]; other site 1249634004882 phosphate binding motif [ion binding]; other site 1249634004883 beta-alpha-beta structure motif; other site 1249634004884 NAD binding pocket [chemical binding]; other site 1249634004885 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1249634004886 catalytic loop [active] 1249634004887 iron binding site [ion binding]; other site 1249634004888 hybrid cluster protein; Provisional; Region: PRK05290 1249634004889 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1249634004890 ACS interaction site; other site 1249634004891 CODH interaction site; other site 1249634004892 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 1249634004893 hybrid metal cluster; other site 1249634004894 Predicted membrane protein [Function unknown]; Region: COG2431 1249634004895 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1249634004896 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 1249634004897 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1249634004898 putative active site [active] 1249634004899 putative metal-binding site [ion binding]; other site 1249634004900 Protein of unknown function (DUF535); Region: DUF535; pfam04393 1249634004901 macrolide transporter subunit MacA; Provisional; Region: PRK11578 1249634004902 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1249634004903 HlyD family secretion protein; Region: HlyD_3; pfam13437 1249634004904 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1249634004905 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1249634004906 Walker A/P-loop; other site 1249634004907 ATP binding site [chemical binding]; other site 1249634004908 Q-loop/lid; other site 1249634004909 ABC transporter signature motif; other site 1249634004910 Walker B; other site 1249634004911 D-loop; other site 1249634004912 H-loop/switch region; other site 1249634004913 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1249634004914 FtsX-like permease family; Region: FtsX; pfam02687 1249634004915 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1249634004916 DNA-binding site [nucleotide binding]; DNA binding site 1249634004917 RNA-binding motif; other site 1249634004918 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1249634004919 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 1249634004920 Clp amino terminal domain; Region: Clp_N; pfam02861 1249634004921 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1249634004922 Walker A motif; other site 1249634004923 ATP binding site [chemical binding]; other site 1249634004924 Walker B motif; other site 1249634004925 arginine finger; other site 1249634004926 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1249634004927 Walker A motif; other site 1249634004928 ATP binding site [chemical binding]; other site 1249634004929 Walker B motif; other site 1249634004930 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1249634004931 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1249634004932 rRNA binding site [nucleotide binding]; other site 1249634004933 predicted 30S ribosome binding site; other site 1249634004934 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1249634004935 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 1249634004936 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 1249634004937 Walker A/P-loop; other site 1249634004938 ATP binding site [chemical binding]; other site 1249634004939 Q-loop/lid; other site 1249634004940 ABC transporter signature motif; other site 1249634004941 Walker B; other site 1249634004942 D-loop; other site 1249634004943 H-loop/switch region; other site 1249634004944 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 1249634004945 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1249634004946 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1249634004947 Q-loop/lid; other site 1249634004948 ABC transporter signature motif; other site 1249634004949 Walker B; other site 1249634004950 D-loop; other site 1249634004951 H-loop/switch region; other site 1249634004952 thioredoxin reductase; Provisional; Region: PRK10262 1249634004953 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1249634004954 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1249634004955 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1249634004956 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1249634004957 putative DNA binding site [nucleotide binding]; other site 1249634004958 putative Zn2+ binding site [ion binding]; other site 1249634004959 AsnC family; Region: AsnC_trans_reg; pfam01037 1249634004960 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634004961 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1249634004962 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1249634004963 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 1249634004964 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1249634004965 recombination factor protein RarA; Reviewed; Region: PRK13342 1249634004966 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1249634004967 Walker A motif; other site 1249634004968 ATP binding site [chemical binding]; other site 1249634004969 Walker B motif; other site 1249634004970 arginine finger; other site 1249634004971 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1249634004972 seryl-tRNA synthetase; Provisional; Region: PRK05431 1249634004973 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1249634004974 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1249634004975 dimer interface [polypeptide binding]; other site 1249634004976 active site 1249634004977 motif 1; other site 1249634004978 motif 2; other site 1249634004979 motif 3; other site 1249634004980 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1249634004981 nudix motif; other site 1249634004982 putative MFS family transporter protein; Provisional; Region: PRK03633 1249634004983 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634004984 putative substrate translocation pore; other site 1249634004985 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 1249634004986 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1249634004987 FeS/SAM binding site; other site 1249634004988 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1249634004989 Pyruvate formate lyase 1; Region: PFL1; cd01678 1249634004990 coenzyme A binding site [chemical binding]; other site 1249634004991 active site 1249634004992 catalytic residues [active] 1249634004993 glycine loop; other site 1249634004994 formate transporter; Provisional; Region: PRK10805 1249634004995 uncharacterized domain; Region: TIGR00702 1249634004996 YcaO-like family; Region: YcaO; pfam02624 1249634004997 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1249634004998 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1249634004999 Trp docking motif [polypeptide binding]; other site 1249634005000 putative active site [active] 1249634005001 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 1249634005002 homodimer interface [polypeptide binding]; other site 1249634005003 active site 1249634005004 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1249634005005 homodimer interface [polypeptide binding]; other site 1249634005006 substrate-cofactor binding pocket; other site 1249634005007 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634005008 catalytic residue [active] 1249634005009 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1249634005010 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1249634005011 hinge; other site 1249634005012 active site 1249634005013 cytidylate kinase; Provisional; Region: cmk; PRK00023 1249634005014 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1249634005015 CMP-binding site; other site 1249634005016 The sites determining sugar specificity; other site 1249634005017 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1249634005018 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1249634005019 RNA binding site [nucleotide binding]; other site 1249634005020 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1249634005021 RNA binding site [nucleotide binding]; other site 1249634005022 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 1249634005023 RNA binding site [nucleotide binding]; other site 1249634005024 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 1249634005025 RNA binding site [nucleotide binding]; other site 1249634005026 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1249634005027 RNA binding site [nucleotide binding]; other site 1249634005028 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1249634005029 IHF dimer interface [polypeptide binding]; other site 1249634005030 IHF - DNA interface [nucleotide binding]; other site 1249634005031 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1249634005032 ComEC family competence protein; Provisional; Region: PRK11539 1249634005033 Competence protein; Region: Competence; pfam03772 1249634005034 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1249634005035 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 1249634005036 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1249634005037 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1249634005038 Walker A/P-loop; other site 1249634005039 ATP binding site [chemical binding]; other site 1249634005040 Q-loop/lid; other site 1249634005041 ABC transporter signature motif; other site 1249634005042 Walker B; other site 1249634005043 D-loop; other site 1249634005044 H-loop/switch region; other site 1249634005045 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 1249634005046 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1249634005047 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 1249634005048 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1249634005049 contains cspA thermoregulator; D781_1621; IMG reference gene:2517283011 1249634005050 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1249634005051 DNA-binding site [nucleotide binding]; DNA binding site 1249634005052 RNA-binding motif; other site 1249634005053 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1249634005054 DNA-binding site [nucleotide binding]; DNA binding site 1249634005055 RNA-binding motif; other site 1249634005056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1249634005057 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1249634005058 Trm112p-like protein; Region: Trm112p; cl01066 1249634005059 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1249634005060 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1249634005061 Ligand binding site; other site 1249634005062 oligomer interface; other site 1249634005063 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1249634005064 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1249634005065 putative active site [active] 1249634005066 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1249634005067 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1249634005068 S-adenosylmethionine binding site [chemical binding]; other site 1249634005069 condesin subunit F; Provisional; Region: PRK05260 1249634005070 condesin subunit E; Provisional; Region: PRK05256 1249634005071 cell division protein MukB; Provisional; Region: mukB; PRK04863 1249634005072 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1249634005073 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1249634005074 murein L,D-transpeptidase; Provisional; Region: PRK10594 1249634005075 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1249634005076 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1249634005077 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1249634005078 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 1249634005079 Peptidase M15; Region: Peptidase_M15_3; cl01194 1249634005080 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1249634005081 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1249634005082 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1249634005083 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634005084 homodimer interface [polypeptide binding]; other site 1249634005085 catalytic residue [active] 1249634005086 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1249634005087 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1249634005088 trimer interface [polypeptide binding]; other site 1249634005089 eyelet of channel; other site 1249634005090 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1249634005091 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1249634005092 putative dimer interface [polypeptide binding]; other site 1249634005093 putative anticodon binding site; other site 1249634005094 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1249634005095 homodimer interface [polypeptide binding]; other site 1249634005096 motif 1; other site 1249634005097 motif 2; other site 1249634005098 active site 1249634005099 motif 3; other site 1249634005100 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 1249634005101 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 1249634005102 active site 1249634005103 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1249634005104 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1249634005105 metal binding site [ion binding]; metal-binding site 1249634005106 active site 1249634005107 I-site; other site 1249634005108 aminopeptidase N; Provisional; Region: pepN; PRK14015 1249634005109 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1249634005110 active site 1249634005111 Zn binding site [ion binding]; other site 1249634005112 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 1249634005113 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1249634005114 Walker A/P-loop; other site 1249634005115 ATP binding site [chemical binding]; other site 1249634005116 Q-loop/lid; other site 1249634005117 ABC transporter signature motif; other site 1249634005118 Walker B; other site 1249634005119 D-loop; other site 1249634005120 H-loop/switch region; other site 1249634005121 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1249634005122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634005123 dimer interface [polypeptide binding]; other site 1249634005124 conserved gate region; other site 1249634005125 putative PBP binding loops; other site 1249634005126 ABC-ATPase subunit interface; other site 1249634005127 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1249634005128 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1249634005129 active site 1249634005130 dimer interface [polypeptide binding]; other site 1249634005131 non-prolyl cis peptide bond; other site 1249634005132 insertion regions; other site 1249634005133 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1249634005134 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1249634005135 substrate binding pocket [chemical binding]; other site 1249634005136 membrane-bound complex binding site; other site 1249634005137 hinge residues; other site 1249634005138 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 1249634005139 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1249634005140 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1249634005141 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1249634005142 quinone interaction residues [chemical binding]; other site 1249634005143 active site 1249634005144 catalytic residues [active] 1249634005145 FMN binding site [chemical binding]; other site 1249634005146 substrate binding site [chemical binding]; other site 1249634005147 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 1249634005148 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1249634005149 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1249634005150 MOSC domain; Region: MOSC; pfam03473 1249634005151 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1249634005152 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1249634005153 catalytic loop [active] 1249634005154 iron binding site [ion binding]; other site 1249634005155 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1249634005156 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1249634005157 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 1249634005158 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1249634005159 S-adenosylmethionine binding site [chemical binding]; other site 1249634005160 ABC transporter ATPase component; Reviewed; Region: PRK11147 1249634005161 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1249634005162 Walker A/P-loop; other site 1249634005163 ATP binding site [chemical binding]; other site 1249634005164 Q-loop/lid; other site 1249634005165 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1249634005166 ABC transporter; Region: ABC_tran_2; pfam12848 1249634005167 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1249634005168 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 1249634005169 Paraquat-inducible protein A; Region: PqiA; pfam04403 1249634005170 Paraquat-inducible protein A; Region: PqiA; pfam04403 1249634005171 paraquat-inducible protein B; Provisional; Region: PRK10807 1249634005172 mce related protein; Region: MCE; pfam02470 1249634005173 mce related protein; Region: MCE; pfam02470 1249634005174 mce related protein; Region: MCE; pfam02470 1249634005175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 1249634005176 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1249634005177 Ribosome modulation factor; Region: RMF; pfam04957 1249634005178 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1249634005179 active site 2 [active] 1249634005180 dimer interface [polypeptide binding]; other site 1249634005181 active site 1 [active] 1249634005182 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 1249634005183 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1249634005184 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 1249634005185 outer membrane protein A; Reviewed; Region: PRK10808 1249634005186 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 1249634005187 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1249634005188 ligand binding site [chemical binding]; other site 1249634005189 SOS cell division inhibitor; Provisional; Region: PRK10595 1249634005190 TfoX N-terminal domain; Region: TfoX_N; pfam04993 1249634005191 TfoX C-terminal domain; Region: TfoX_C; pfam04994 1249634005192 TIGR01666 family membrane protein; Region: YCCS 1249634005193 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1249634005194 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1249634005195 Predicted membrane protein [Function unknown]; Region: COG3304 1249634005196 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1249634005197 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1249634005198 DNA helicase IV; Provisional; Region: helD; PRK11054 1249634005199 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 1249634005200 Part of AAA domain; Region: AAA_19; pfam13245 1249634005201 Family description; Region: UvrD_C_2; pfam13538 1249634005202 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1249634005203 active site 1249634005204 dimer interfaces [polypeptide binding]; other site 1249634005205 catalytic residues [active] 1249634005206 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437 1249634005207 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1249634005208 heat shock protein HspQ; Provisional; Region: PRK14129 1249634005209 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 1249634005210 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 1249634005211 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1249634005212 putative RNA binding site [nucleotide binding]; other site 1249634005213 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1249634005214 S-adenosylmethionine binding site [chemical binding]; other site 1249634005215 acylphosphatase; Provisional; Region: PRK14426 1249634005216 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1249634005217 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 1249634005218 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1249634005219 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 1249634005220 tetramer interface [polypeptide binding]; other site 1249634005221 catalytic Zn binding site [ion binding]; other site 1249634005222 NADP binding site [chemical binding]; other site 1249634005223 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1249634005224 YccA-like proteins; Region: YccA_like; cd10433 1249634005225 Protein of unknown function (DUF770); Region: DUF770; pfam05591 1249634005226 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 1249634005227 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1249634005228 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 1249634005229 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1249634005230 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 1249634005231 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1249634005232 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1249634005233 ligand binding site [chemical binding]; other site 1249634005234 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1249634005235 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1249634005236 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1249634005237 Walker A motif; other site 1249634005238 ATP binding site [chemical binding]; other site 1249634005239 Walker B motif; other site 1249634005240 arginine finger; other site 1249634005241 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1249634005242 Walker A motif; other site 1249634005243 ATP binding site [chemical binding]; other site 1249634005244 Walker B motif; other site 1249634005245 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1249634005246 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 1249634005247 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1249634005248 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1249634005249 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 1249634005250 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 1249634005251 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 1249634005252 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 1249634005253 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 1249634005254 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 1249634005255 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 1249634005256 PAAR motif; Region: PAAR_motif; pfam05488 1249634005257 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 1249634005258 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1249634005259 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1249634005260 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 1249634005261 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1249634005262 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 1249634005263 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1249634005264 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1249634005265 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 1249634005266 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 1249634005267 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1249634005268 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1249634005269 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1249634005270 putative acyl-acceptor binding pocket; other site 1249634005271 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 1249634005272 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1249634005273 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 1249634005274 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1249634005275 ImpA domain protein; Region: DUF3702; pfam12486 1249634005276 hypothetical protein; Provisional; Region: PRK07236 1249634005277 FAD binding domain; Region: FAD_binding_3; pfam01494 1249634005278 xanthine permease; Region: pbuX; TIGR03173 1249634005279 OHCU decarboxylase; Region: UraD_2; TIGR03180 1249634005280 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1249634005281 active site 1249634005282 homotetramer interface [polypeptide binding]; other site 1249634005283 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 1249634005284 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1249634005285 Na binding site [ion binding]; other site 1249634005286 putative substrate binding site [chemical binding]; other site 1249634005287 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1249634005288 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1249634005289 DNA-binding site [nucleotide binding]; DNA binding site 1249634005290 FCD domain; Region: FCD; pfam07729 1249634005291 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1249634005292 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1249634005293 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 1249634005294 active site 1249634005295 catalytic site [active] 1249634005296 tetramer interface [polypeptide binding]; other site 1249634005297 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 1249634005298 amidase; Provisional; Region: PRK09201 1249634005299 Amidase; Region: Amidase; pfam01425 1249634005300 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 1249634005301 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1249634005302 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1249634005303 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1249634005304 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1249634005305 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1249634005306 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1249634005307 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1249634005308 substrate binding pocket [chemical binding]; other site 1249634005309 membrane-bound complex binding site; other site 1249634005310 hinge residues; other site 1249634005311 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634005312 dimer interface [polypeptide binding]; other site 1249634005313 conserved gate region; other site 1249634005314 putative PBP binding loops; other site 1249634005315 ABC-ATPase subunit interface; other site 1249634005316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1249634005317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634005318 putative PBP binding loops; other site 1249634005319 dimer interface [polypeptide binding]; other site 1249634005320 ABC-ATPase subunit interface; other site 1249634005321 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1249634005322 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1249634005323 Walker A/P-loop; other site 1249634005324 ATP binding site [chemical binding]; other site 1249634005325 Q-loop/lid; other site 1249634005326 ABC transporter signature motif; other site 1249634005327 Walker B; other site 1249634005328 D-loop; other site 1249634005329 H-loop/switch region; other site 1249634005330 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1249634005331 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1249634005332 catalytic residue [active] 1249634005333 allantoate amidohydrolase; Reviewed; Region: PRK09290 1249634005334 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1249634005335 active site 1249634005336 metal binding site [ion binding]; metal-binding site 1249634005337 dimer interface [polypeptide binding]; other site 1249634005338 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1249634005339 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1249634005340 Cytochrome c; Region: Cytochrom_C; pfam00034 1249634005341 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1249634005342 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1249634005343 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1249634005344 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1249634005345 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1249634005346 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1249634005347 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1249634005348 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1249634005349 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 1249634005350 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 1249634005351 Predicted membrane protein [Function unknown]; Region: COG4984 1249634005352 Domain of unknown function (DUF4401); Region: DUF4401; pfam14351 1249634005353 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1249634005354 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1249634005355 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1249634005356 Walker A motif; other site 1249634005357 ATP binding site [chemical binding]; other site 1249634005358 Walker B motif; other site 1249634005359 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1249634005360 Walker A motif; other site 1249634005361 ATP binding site [chemical binding]; other site 1249634005362 Walker B motif; other site 1249634005363 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1249634005364 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1249634005365 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1249634005366 N-terminal plug; other site 1249634005367 ligand-binding site [chemical binding]; other site 1249634005368 hypothetical protein; Provisional; Region: PRK10536 1249634005369 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1249634005370 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 1249634005371 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 1249634005372 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1249634005373 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1249634005374 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1249634005375 FAD binding pocket [chemical binding]; other site 1249634005376 FAD binding motif [chemical binding]; other site 1249634005377 phosphate binding motif [ion binding]; other site 1249634005378 NAD binding pocket [chemical binding]; other site 1249634005379 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 1249634005380 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1249634005381 putative active site pocket [active] 1249634005382 dimerization interface [polypeptide binding]; other site 1249634005383 putative catalytic residue [active] 1249634005384 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 1249634005385 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 1249634005386 substrate binding site [chemical binding]; other site 1249634005387 dimerization interface [polypeptide binding]; other site 1249634005388 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 1249634005389 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1249634005390 active site 1249634005391 substrate binding site [chemical binding]; other site 1249634005392 Mg2+ binding site [ion binding]; other site 1249634005393 BCCT family transporter; Region: BCCT; cl00569 1249634005394 Cation transport protein; Region: TrkH; cl17365 1249634005395 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1249634005396 LysE type translocator; Region: LysE; cl00565 1249634005397 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1249634005398 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634005399 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1249634005400 dimerization interface [polypeptide binding]; other site 1249634005401 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1249634005402 sequence-specific DNA binding site [nucleotide binding]; other site 1249634005403 salt bridge; other site 1249634005404 Cupin domain; Region: Cupin_2; cl17218 1249634005405 EamA-like transporter family; Region: EamA; pfam00892 1249634005406 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1249634005407 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1249634005408 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 1249634005409 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1249634005410 Ligand Binding Site [chemical binding]; other site 1249634005411 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 1249634005412 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1249634005413 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1249634005414 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1249634005415 dimer interface [polypeptide binding]; other site 1249634005416 NADP binding site [chemical binding]; other site 1249634005417 catalytic residues [active] 1249634005418 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1249634005419 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1249634005420 inhibitor site; inhibition site 1249634005421 active site 1249634005422 dimer interface [polypeptide binding]; other site 1249634005423 catalytic residue [active] 1249634005424 PAS fold; Region: PAS_4; pfam08448 1249634005425 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1249634005426 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634005427 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 1249634005428 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1249634005429 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1249634005430 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1249634005431 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1249634005432 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1249634005433 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 1249634005434 hypothetical protein; Provisional; Region: PRK10613 1249634005435 response regulator; Provisional; Region: PRK09483 1249634005436 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634005437 active site 1249634005438 phosphorylation site [posttranslational modification] 1249634005439 intermolecular recognition site; other site 1249634005440 dimerization interface [polypeptide binding]; other site 1249634005441 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1249634005442 DNA binding residues [nucleotide binding] 1249634005443 dimerization interface [polypeptide binding]; other site 1249634005444 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1249634005445 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1249634005446 GIY-YIG motif/motif A; other site 1249634005447 active site 1249634005448 catalytic site [active] 1249634005449 putative DNA binding site [nucleotide binding]; other site 1249634005450 metal binding site [ion binding]; metal-binding site 1249634005451 UvrB/uvrC motif; Region: UVR; pfam02151 1249634005452 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1249634005453 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1249634005454 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 1249634005455 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1249634005456 active site 1249634005457 NTP binding site [chemical binding]; other site 1249634005458 metal binding triad [ion binding]; metal-binding site 1249634005459 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1249634005460 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1249634005461 DNA binding site [nucleotide binding] 1249634005462 domain linker motif; other site 1249634005463 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1249634005464 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1249634005465 dimer interface [polypeptide binding]; other site 1249634005466 active site 1249634005467 Schiff base residues; other site 1249634005468 proline/glycine betaine transporter; Provisional; Region: PRK10642 1249634005469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634005470 putative substrate translocation pore; other site 1249634005471 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 1249634005472 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 1249634005473 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 1249634005474 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1249634005475 TrkA-C domain; Region: TrkA_C; pfam02080 1249634005476 Transporter associated domain; Region: CorC_HlyC; smart01091 1249634005477 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1249634005478 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1249634005479 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 1249634005480 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 1249634005481 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1249634005482 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 1249634005483 Ligand binding site; other site 1249634005484 DXD motif; other site 1249634005485 lipoprotein; Provisional; Region: PRK10175 1249634005486 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1249634005487 MsyB protein; Region: MsyB; cl08181 1249634005488 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1249634005489 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1249634005490 NAD(P) binding site [chemical binding]; other site 1249634005491 catalytic residues [active] 1249634005492 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1249634005493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634005494 putative substrate translocation pore; other site 1249634005495 POT family; Region: PTR2; cl17359 1249634005496 drug efflux system protein MdtG; Provisional; Region: PRK09874 1249634005497 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634005498 putative substrate translocation pore; other site 1249634005499 YCII-related domain; Region: YCII; cl00999 1249634005500 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1249634005501 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1249634005502 putative acyl-acceptor binding pocket; other site 1249634005503 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1249634005504 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1249634005505 active site 1249634005506 FMN binding site [chemical binding]; other site 1249634005507 substrate binding site [chemical binding]; other site 1249634005508 homotetramer interface [polypeptide binding]; other site 1249634005509 catalytic residue [active] 1249634005510 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1249634005511 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1249634005512 active site residue [active] 1249634005513 hypothetical protein; Provisional; Region: PRK03757 1249634005514 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1249634005515 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 1249634005516 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1249634005517 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 1249634005518 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1249634005519 DNA binding residues [nucleotide binding] 1249634005520 dimerization interface [polypeptide binding]; other site 1249634005521 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1249634005522 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1249634005523 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 1249634005524 DNA damage-inducible protein I; Provisional; Region: PRK10597 1249634005525 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1249634005526 active site 1249634005527 substrate binding pocket [chemical binding]; other site 1249634005528 dimer interface [polypeptide binding]; other site 1249634005529 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1249634005530 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 1249634005531 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1249634005532 homodimer interface [polypeptide binding]; other site 1249634005533 oligonucleotide binding site [chemical binding]; other site 1249634005534 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 1249634005535 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1249634005536 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1249634005537 RNA binding surface [nucleotide binding]; other site 1249634005538 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1249634005539 active site 1249634005540 Maf-like protein; Region: Maf; pfam02545 1249634005541 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1249634005542 active site 1249634005543 dimer interface [polypeptide binding]; other site 1249634005544 hypothetical protein; Provisional; Region: PRK11193 1249634005545 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1249634005546 Fatty acid/phospholipid biosynthesis enzyme [Lipid metabolism]; Region: PlsX; COG0416 1249634005547 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1249634005548 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1249634005549 dimer interface [polypeptide binding]; other site 1249634005550 active site 1249634005551 CoA binding pocket [chemical binding]; other site 1249634005552 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1249634005553 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1249634005554 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1249634005555 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1249634005556 NAD(P) binding site [chemical binding]; other site 1249634005557 homotetramer interface [polypeptide binding]; other site 1249634005558 homodimer interface [polypeptide binding]; other site 1249634005559 active site 1249634005560 acyl carrier protein; Provisional; Region: acpP; PRK00982 1249634005561 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1249634005562 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1249634005563 dimer interface [polypeptide binding]; other site 1249634005564 active site 1249634005565 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1249634005566 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1249634005567 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634005568 catalytic residue [active] 1249634005569 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 1249634005570 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1249634005571 dimerization interface [polypeptide binding]; other site 1249634005572 thymidylate kinase; Validated; Region: tmk; PRK00698 1249634005573 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1249634005574 TMP-binding site; other site 1249634005575 ATP-binding site [chemical binding]; other site 1249634005576 DNA polymerase III subunit delta'; Validated; Region: PRK07993 1249634005577 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1249634005578 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 1249634005579 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1249634005580 active site 1249634005581 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 1249634005582 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1249634005583 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1249634005584 active site turn [active] 1249634005585 phosphorylation site [posttranslational modification] 1249634005586 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1249634005587 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1249634005588 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1249634005589 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 1249634005590 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1249634005591 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1249634005592 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1249634005593 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1249634005594 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1249634005595 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1249634005596 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1249634005597 zinc/cadmium-binding protein; Provisional; Region: PRK10306 1249634005598 short chain dehydrogenase; Provisional; Region: PRK06500 1249634005599 classical (c) SDRs; Region: SDR_c; cd05233 1249634005600 NAD(P) binding site [chemical binding]; other site 1249634005601 active site 1249634005602 Predicted transcriptional regulators [Transcription]; Region: COG1733 1249634005603 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1249634005604 putative DNA binding site [nucleotide binding]; other site 1249634005605 dimerization interface [polypeptide binding]; other site 1249634005606 putative Zn2+ binding site [ion binding]; other site 1249634005607 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1249634005608 nucleotide binding site/active site [active] 1249634005609 HIT family signature motif; other site 1249634005610 catalytic residue [active] 1249634005611 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 1249634005612 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 1249634005613 putative dimer interface [polypeptide binding]; other site 1249634005614 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 1249634005615 thiamine kinase; Region: ycfN_thiK; TIGR02721 1249634005616 active site 1249634005617 substrate binding site [chemical binding]; other site 1249634005618 ATP binding site [chemical binding]; other site 1249634005619 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1249634005620 beta-hexosaminidase; Provisional; Region: PRK05337 1249634005621 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1249634005622 hypothetical protein; Provisional; Region: PRK04940 1249634005623 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1249634005624 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1249634005625 hypothetical protein; Provisional; Region: PRK11280 1249634005626 transcription-repair coupling factor; Provisional; Region: PRK10689 1249634005627 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1249634005628 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1249634005629 ATP binding site [chemical binding]; other site 1249634005630 putative Mg++ binding site [ion binding]; other site 1249634005631 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1249634005632 nucleotide binding region [chemical binding]; other site 1249634005633 ATP-binding site [chemical binding]; other site 1249634005634 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1249634005635 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 1249634005636 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1249634005637 FtsX-like permease family; Region: FtsX; pfam02687 1249634005638 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 1249634005639 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1249634005640 Walker A/P-loop; other site 1249634005641 ATP binding site [chemical binding]; other site 1249634005642 Q-loop/lid; other site 1249634005643 ABC transporter signature motif; other site 1249634005644 Walker B; other site 1249634005645 D-loop; other site 1249634005646 H-loop/switch region; other site 1249634005647 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 1249634005648 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1249634005649 FtsX-like permease family; Region: FtsX; pfam02687 1249634005650 fructokinase; Reviewed; Region: PRK09557 1249634005651 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1249634005652 nucleotide binding site [chemical binding]; other site 1249634005653 NAD-dependent deacetylase; Provisional; Region: PRK00481 1249634005654 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1249634005655 NAD+ binding site [chemical binding]; other site 1249634005656 substrate binding site [chemical binding]; other site 1249634005657 Zn binding site [ion binding]; other site 1249634005658 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 1249634005659 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1249634005660 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1249634005661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634005662 dimer interface [polypeptide binding]; other site 1249634005663 conserved gate region; other site 1249634005664 putative PBP binding loops; other site 1249634005665 ABC-ATPase subunit interface; other site 1249634005666 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1249634005667 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634005668 dimer interface [polypeptide binding]; other site 1249634005669 conserved gate region; other site 1249634005670 putative PBP binding loops; other site 1249634005671 ABC-ATPase subunit interface; other site 1249634005672 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 1249634005673 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1249634005674 Walker A/P-loop; other site 1249634005675 ATP binding site [chemical binding]; other site 1249634005676 Q-loop/lid; other site 1249634005677 ABC transporter signature motif; other site 1249634005678 Walker B; other site 1249634005679 D-loop; other site 1249634005680 H-loop/switch region; other site 1249634005681 TOBE domain; Region: TOBE_2; pfam08402 1249634005682 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 1249634005683 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1249634005684 metal binding site [ion binding]; metal-binding site 1249634005685 dimer interface [polypeptide binding]; other site 1249634005686 putative dehydrogenase; Provisional; Region: PRK10098 1249634005687 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1249634005688 S-adenosylmethionine binding site [chemical binding]; other site 1249634005689 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1249634005690 Cupin domain; Region: Cupin_2; cl17218 1249634005691 sensor protein PhoQ; Provisional; Region: PRK10815 1249634005692 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 1249634005693 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1249634005694 dimer interface [polypeptide binding]; other site 1249634005695 phosphorylation site [posttranslational modification] 1249634005696 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1249634005697 ATP binding site [chemical binding]; other site 1249634005698 Mg2+ binding site [ion binding]; other site 1249634005699 G-X-G motif; other site 1249634005700 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 1249634005701 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634005702 active site 1249634005703 phosphorylation site [posttranslational modification] 1249634005704 intermolecular recognition site; other site 1249634005705 dimerization interface [polypeptide binding]; other site 1249634005706 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1249634005707 DNA binding site [nucleotide binding] 1249634005708 adenylosuccinate lyase; Provisional; Region: PRK09285 1249634005709 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1249634005710 tetramer interface [polypeptide binding]; other site 1249634005711 active site 1249634005712 putative lysogenization regulator; Reviewed; Region: PRK00218 1249634005713 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1249634005714 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1249634005715 Ligand Binding Site [chemical binding]; other site 1249634005716 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 1249634005717 nudix motif; other site 1249634005718 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1249634005719 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 1249634005720 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 1249634005721 probable active site [active] 1249634005722 isocitrate dehydrogenase; Validated; Region: PRK07362 1249634005723 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1249634005724 HNH endonuclease; Region: HNH_2; pfam13391 1249634005725 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1249634005726 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1249634005727 Catalytic site [active] 1249634005728 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1249634005729 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1249634005730 active site 1249634005731 DNA binding site [nucleotide binding] 1249634005732 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1249634005733 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1249634005734 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 1249634005735 active site 1249634005736 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1249634005737 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1249634005738 Bor protein; Region: Lambda_Bor; pfam06291 1249634005739 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1249634005740 cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976 1249634005741 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1249634005742 catalytic residue [active] 1249634005743 Biofilm formation and stress response factor; Region: BsmA; cl01794 1249634005744 CsbD-like; Region: CsbD; pfam05532 1249634005745 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1249634005746 DNA binding site [nucleotide binding] 1249634005747 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1249634005748 Ligand Binding Site [chemical binding]; other site 1249634005749 short chain dehydrogenase; Provisional; Region: PRK06138 1249634005750 classical (c) SDRs; Region: SDR_c; cd05233 1249634005751 NAD(P) binding site [chemical binding]; other site 1249634005752 active site 1249634005753 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1249634005754 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1249634005755 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 1249634005756 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1249634005757 NAD(P) binding site [chemical binding]; other site 1249634005758 catalytic residues [active] 1249634005759 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1249634005760 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1249634005761 non-specific DNA binding site [nucleotide binding]; other site 1249634005762 salt bridge; other site 1249634005763 sequence-specific DNA binding site [nucleotide binding]; other site 1249634005764 Cupin domain; Region: Cupin_2; pfam07883 1249634005765 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 1249634005766 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1249634005767 catalytic triad [active] 1249634005768 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1249634005769 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1249634005770 amino acid transporter; Region: 2A0306; TIGR00909 1249634005771 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 1249634005772 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 1249634005773 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1249634005774 chorismate mutase; Provisional; Region: PRK08055 1249634005775 Beta-lactamase; Region: Beta-lactamase; pfam00144 1249634005776 D-aminopeptidase; Reviewed; Region: PRK13128 1249634005777 N-formylglutamate amidohydrolase; Region: FGase; cl01522 1249634005778 imidazolonepropionase; Validated; Region: PRK09356 1249634005779 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1249634005780 active site 1249634005781 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 1249634005782 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1249634005783 DNA-binding site [nucleotide binding]; DNA binding site 1249634005784 UTRA domain; Region: UTRA; pfam07702 1249634005785 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 1249634005786 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 1249634005787 active site 1249634005788 HutD; Region: HutD; pfam05962 1249634005789 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1249634005790 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1249634005791 DNA binding site [nucleotide binding] 1249634005792 domain linker motif; other site 1249634005793 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 1249634005794 putative dimerization interface [polypeptide binding]; other site 1249634005795 putative ligand binding site [chemical binding]; other site 1249634005796 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1249634005797 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1249634005798 substrate binding [chemical binding]; other site 1249634005799 active site 1249634005800 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1249634005801 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634005802 oligosaccharide:H+ symporter; Region: 2A0105; TIGR00882 1249634005803 putative substrate translocation pore; other site 1249634005804 metabolite-proton symporter; Region: 2A0106; TIGR00883 1249634005805 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1249634005806 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1249634005807 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1249634005808 Cytochrome c; Region: Cytochrom_C; pfam00034 1249634005809 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1249634005810 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1249634005811 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 1249634005812 Domain of unknown function (DUF336); Region: DUF336; pfam03928 1249634005813 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1249634005814 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1249634005815 NAD binding site [chemical binding]; other site 1249634005816 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 1249634005817 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 1249634005818 hypothetical protein; Provisional; Region: PRK09262 1249634005819 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1249634005820 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634005821 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1249634005822 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634005823 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 1249634005824 putative dimerization interface [polypeptide binding]; other site 1249634005825 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1249634005826 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1249634005827 trimer interface [polypeptide binding]; other site 1249634005828 active site 1249634005829 dimer interface [polypeptide binding]; other site 1249634005830 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1249634005831 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1249634005832 active site 1249634005833 protocatechuate 4,5-dioxygenase; Provisional; Region: PRK13367 1249634005834 The N-terminal domain of the Class III extradiol dioxygenase, Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_Doxase_N; cd07950 1249634005835 putative active site [active] 1249634005836 Fe(II) binding site [ion binding]; other site 1249634005837 putative dimer interface [polypeptide binding]; other site 1249634005838 The C-terminal domain of Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_dioxygenase_C; cd07923 1249634005839 putative dimer interface [polypeptide binding]; other site 1249634005840 putative N- and C-terminal domain interface [polypeptide binding]; other site 1249634005841 benzoate transport; Region: 2A0115; TIGR00895 1249634005842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634005843 putative substrate translocation pore; other site 1249634005844 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1249634005845 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1249634005846 active site 1249634005847 substrate-binding site [chemical binding]; other site 1249634005848 metal-binding site [ion binding] 1249634005849 ATP binding site [chemical binding]; other site 1249634005850 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 1249634005851 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1249634005852 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 1249634005853 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 1249634005854 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1249634005855 S-adenosylmethionine binding site [chemical binding]; other site 1249634005856 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1249634005857 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1249634005858 mce related protein; Region: MCE; pfam02470 1249634005859 mce related protein; Region: MCE; pfam02470 1249634005860 mce related protein; Region: MCE; pfam02470 1249634005861 mce related protein; Region: MCE; pfam02470 1249634005862 mce related protein; Region: MCE; pfam02470 1249634005863 mce related protein; Region: MCE; pfam02470 1249634005864 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 1249634005865 Paraquat-inducible protein A; Region: PqiA; pfam04403 1249634005866 Paraquat-inducible protein A; Region: PqiA; pfam04403 1249634005867 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1249634005868 GAF domain; Region: GAF_2; pfam13185 1249634005869 ProP expression regulator; Provisional; Region: PRK04950 1249634005870 ProQ/FINO family; Region: ProQ; pfam04352 1249634005871 putative RNA binding sites [nucleotide binding]; other site 1249634005872 carboxy-terminal protease; Provisional; Region: PRK11186 1249634005873 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1249634005874 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1249634005875 protein binding site [polypeptide binding]; other site 1249634005876 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1249634005877 Catalytic dyad [active] 1249634005878 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 1249634005879 heat shock protein HtpX; Provisional; Region: PRK05457 1249634005880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634005881 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1249634005882 putative substrate translocation pore; other site 1249634005883 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634005884 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 1249634005885 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1249634005886 dimerization interface [polypeptide binding]; other site 1249634005887 putative Zn2+ binding site [ion binding]; other site 1249634005888 putative DNA binding site [nucleotide binding]; other site 1249634005889 Bacterial transcriptional regulator; Region: IclR; pfam01614 1249634005890 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1249634005891 transcriptional regulator protein; Region: phnR; TIGR03337 1249634005892 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1249634005893 DNA-binding site [nucleotide binding]; DNA binding site 1249634005894 UTRA domain; Region: UTRA; pfam07702 1249634005895 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 1249634005896 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1249634005897 catalytic residue [active] 1249634005898 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 1249634005899 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1249634005900 motif II; other site 1249634005901 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1249634005902 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1249634005903 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1249634005904 inner membrane protein; Provisional; Region: PRK11648 1249634005905 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 1249634005906 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1249634005907 NADP binding site [chemical binding]; other site 1249634005908 homodimer interface [polypeptide binding]; other site 1249634005909 active site 1249634005910 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1249634005911 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 1249634005912 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1249634005913 motif II; other site 1249634005914 YniB-like protein; Region: YniB; pfam14002 1249634005915 Fructosamine kinase; Region: Fructosamin_kin; pfam03881 1249634005916 Phosphotransferase enzyme family; Region: APH; pfam01636 1249634005917 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1249634005918 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1249634005919 ABC-ATPase subunit interface; other site 1249634005920 dimer interface [polypeptide binding]; other site 1249634005921 putative PBP binding regions; other site 1249634005922 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1249634005923 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1249634005924 ABC-ATPase subunit interface; other site 1249634005925 dimer interface [polypeptide binding]; other site 1249634005926 putative PBP binding regions; other site 1249634005927 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 1249634005928 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1249634005929 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1249634005930 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1249634005931 metal binding site [ion binding]; metal-binding site 1249634005932 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 1249634005933 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1249634005934 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1249634005935 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1249634005936 catalytic residue [active] 1249634005937 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 1249634005938 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1249634005939 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1249634005940 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1249634005941 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1249634005942 Cytochrome c; Region: Cytochrom_C; cl11414 1249634005943 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1249634005944 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1249634005945 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1249634005946 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1249634005947 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 1249634005948 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1249634005949 intersubunit interface [polypeptide binding]; other site 1249634005950 Right handed beta helix region; Region: Beta_helix; pfam13229 1249634005951 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1249634005952 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1249634005953 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1249634005954 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1249634005955 active site 1249634005956 dimer interface [polypeptide binding]; other site 1249634005957 motif 1; other site 1249634005958 motif 2; other site 1249634005959 motif 3; other site 1249634005960 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1249634005961 anticodon binding site; other site 1249634005962 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1249634005963 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1249634005964 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1249634005965 Long range pseudoknot; IMG reference gene:2517283362; D781_1972 1249634005966 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1249634005967 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1249634005968 23S rRNA binding site [nucleotide binding]; other site 1249634005969 L21 binding site [polypeptide binding]; other site 1249634005970 L13 binding site [polypeptide binding]; other site 1249634005971 Phenylalanine leader peptide; D781_1975; IMG reference gene:2517283365 1249634005972 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1249634005973 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1249634005974 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1249634005975 dimer interface [polypeptide binding]; other site 1249634005976 motif 1; other site 1249634005977 active site 1249634005978 motif 2; other site 1249634005979 motif 3; other site 1249634005980 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1249634005981 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1249634005982 putative tRNA-binding site [nucleotide binding]; other site 1249634005983 B3/4 domain; Region: B3_4; pfam03483 1249634005984 tRNA synthetase B5 domain; Region: B5; smart00874 1249634005985 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1249634005986 dimer interface [polypeptide binding]; other site 1249634005987 motif 1; other site 1249634005988 motif 3; other site 1249634005989 motif 2; other site 1249634005990 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1249634005991 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1249634005992 IHF dimer interface [polypeptide binding]; other site 1249634005993 IHF - DNA interface [nucleotide binding]; other site 1249634005994 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 1249634005995 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1249634005996 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1249634005997 dimer interface [polypeptide binding]; other site 1249634005998 putative PBP binding regions; other site 1249634005999 ABC-ATPase subunit interface; other site 1249634006000 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1249634006001 catalytic residues [active] 1249634006002 dimer interface [polypeptide binding]; other site 1249634006003 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 1249634006004 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1249634006005 Walker A/P-loop; other site 1249634006006 ATP binding site [chemical binding]; other site 1249634006007 Q-loop/lid; other site 1249634006008 ABC transporter signature motif; other site 1249634006009 Walker B; other site 1249634006010 D-loop; other site 1249634006011 H-loop/switch region; other site 1249634006012 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1249634006013 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1249634006014 inhibitor-cofactor binding pocket; inhibition site 1249634006015 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634006016 catalytic residue [active] 1249634006017 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1249634006018 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1249634006019 Ligand binding site; other site 1249634006020 Putative Catalytic site; other site 1249634006021 DXD motif; other site 1249634006022 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 1249634006023 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1249634006024 active site 1249634006025 substrate binding site [chemical binding]; other site 1249634006026 cosubstrate binding site; other site 1249634006027 catalytic site [active] 1249634006028 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 1249634006029 active site 1249634006030 hexamer interface [polypeptide binding]; other site 1249634006031 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 1249634006032 NAD binding site [chemical binding]; other site 1249634006033 substrate binding site [chemical binding]; other site 1249634006034 active site 1249634006035 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 1249634006036 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 1249634006037 putative active site [active] 1249634006038 putative catalytic site [active] 1249634006039 putative Zn binding site [ion binding]; other site 1249634006040 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 1249634006041 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1249634006042 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 1249634006043 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 1249634006044 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 1249634006045 NlpC/P60 family; Region: NLPC_P60; pfam00877 1249634006046 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 1249634006047 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1249634006048 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1249634006049 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1249634006050 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1249634006051 hypothetical protein; Validated; Region: PRK00029 1249634006052 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1249634006053 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1249634006054 Walker A/P-loop; other site 1249634006055 ATP binding site [chemical binding]; other site 1249634006056 Q-loop/lid; other site 1249634006057 ABC transporter signature motif; other site 1249634006058 Walker B; other site 1249634006059 D-loop; other site 1249634006060 H-loop/switch region; other site 1249634006061 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1249634006062 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1249634006063 ABC-ATPase subunit interface; other site 1249634006064 dimer interface [polypeptide binding]; other site 1249634006065 putative PBP binding regions; other site 1249634006066 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 1249634006067 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1249634006068 putative hemin binding site; other site 1249634006069 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 1249634006070 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 1249634006071 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 1249634006072 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1249634006073 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1249634006074 N-terminal plug; other site 1249634006075 ligand-binding site [chemical binding]; other site 1249634006076 Hemin uptake protein hemP; Region: hemP; pfam10636 1249634006077 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1249634006078 catalytic residues [active] 1249634006079 dimer interface [polypeptide binding]; other site 1249634006080 Isochorismatase family; Region: Isochorismatase; pfam00857 1249634006081 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1249634006082 catalytic triad [active] 1249634006083 dimer interface [polypeptide binding]; other site 1249634006084 conserved cis-peptide bond; other site 1249634006085 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1249634006086 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1249634006087 heme binding site [chemical binding]; other site 1249634006088 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1249634006089 heme binding site [chemical binding]; other site 1249634006090 PAAR motif; Region: PAAR_motif; pfam05488 1249634006091 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1249634006092 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1249634006093 RHS Repeat; Region: RHS_repeat; pfam05593 1249634006094 RHS Repeat; Region: RHS_repeat; pfam05593 1249634006095 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1249634006096 RHS Repeat; Region: RHS_repeat; cl11982 1249634006097 RHS protein; Region: RHS; pfam03527 1249634006098 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1249634006099 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1249634006100 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1249634006101 N-terminal plug; other site 1249634006102 ligand-binding site [chemical binding]; other site 1249634006103 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 1249634006104 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1249634006105 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1249634006106 MbtH-like protein; Region: MbtH; pfam03621 1249634006107 Condensation domain; Region: Condensation; pfam00668 1249634006108 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1249634006109 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1249634006110 acyl-activating enzyme (AAE) consensus motif; other site 1249634006111 AMP binding site [chemical binding]; other site 1249634006112 Condensation domain; Region: Condensation; pfam00668 1249634006113 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1249634006114 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1249634006115 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1249634006116 acyl-activating enzyme (AAE) consensus motif; other site 1249634006117 AMP binding site [chemical binding]; other site 1249634006118 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1249634006119 enterobactin exporter EntS; Provisional; Region: PRK10489 1249634006120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634006121 putative substrate translocation pore; other site 1249634006122 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634006123 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 1249634006124 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1249634006125 siderophore binding site; other site 1249634006126 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 1249634006127 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1249634006128 N-terminal plug; other site 1249634006129 ligand-binding site [chemical binding]; other site 1249634006130 PQQ-like domain; Region: PQQ_2; pfam13360 1249634006131 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1249634006132 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1249634006133 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1249634006134 N-terminal plug; other site 1249634006135 ligand-binding site [chemical binding]; other site 1249634006136 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1249634006137 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634006138 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 1249634006139 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1249634006140 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1249634006141 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1249634006142 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1249634006143 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1249634006144 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1249634006145 putative inner membrane protein; Provisional; Region: PRK10983 1249634006146 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1249634006147 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1249634006148 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1249634006149 FAD binding domain; Region: FAD_binding_4; pfam01565 1249634006150 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1249634006151 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1249634006152 CoenzymeA binding site [chemical binding]; other site 1249634006153 subunit interaction site [polypeptide binding]; other site 1249634006154 PHB binding site; other site 1249634006155 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 1249634006156 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1249634006157 putative ABC transporter; Region: ycf24; CHL00085 1249634006158 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 1249634006159 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1249634006160 Walker A/P-loop; other site 1249634006161 ATP binding site [chemical binding]; other site 1249634006162 Q-loop/lid; other site 1249634006163 ABC transporter signature motif; other site 1249634006164 Walker B; other site 1249634006165 D-loop; other site 1249634006166 H-loop/switch region; other site 1249634006167 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 1249634006168 FeS assembly protein SufD; Region: sufD; TIGR01981 1249634006169 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1249634006170 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1249634006171 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1249634006172 catalytic residue [active] 1249634006173 cysteine desufuration protein SufE; Provisional; Region: PRK09296 1249634006174 L,D-transpeptidase; Provisional; Region: PRK10190 1249634006175 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1249634006176 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1249634006177 murein lipoprotein; Provisional; Region: PRK15396 1249634006178 pyruvate kinase; Provisional; Region: PRK09206 1249634006179 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1249634006180 domain interfaces; other site 1249634006181 active site 1249634006182 Cupin domain; Region: Cupin_2; cl17218 1249634006183 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1249634006184 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1249634006185 conserved cys residue [active] 1249634006186 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634006187 benzoate transport; Region: 2A0115; TIGR00895 1249634006188 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634006189 putative substrate translocation pore; other site 1249634006190 aromatic amino acid exporter; Provisional; Region: PRK11689 1249634006191 EamA-like transporter family; Region: EamA; pfam00892 1249634006192 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1249634006193 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1249634006194 inhibitor site; inhibition site 1249634006195 active site 1249634006196 dimer interface [polypeptide binding]; other site 1249634006197 catalytic residue [active] 1249634006198 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1249634006199 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1249634006200 NAD(P) binding site [chemical binding]; other site 1249634006201 catalytic residues [active] 1249634006202 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1249634006203 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1249634006204 DNA-binding site [nucleotide binding]; DNA binding site 1249634006205 FCD domain; Region: FCD; pfam07729 1249634006206 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1249634006207 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1249634006208 multidrug efflux protein; Reviewed; Region: PRK01766 1249634006209 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1249634006210 cation binding site [ion binding]; other site 1249634006211 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 1249634006212 Lumazine binding domain; Region: Lum_binding; pfam00677 1249634006213 Lumazine binding domain; Region: Lum_binding; pfam00677 1249634006214 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 1249634006215 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 1249634006216 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1249634006217 S-adenosylmethionine binding site [chemical binding]; other site 1249634006218 putative transporter; Provisional; Region: PRK11043 1249634006219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634006220 putative substrate translocation pore; other site 1249634006221 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1249634006222 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634006223 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1249634006224 dimerization interface [polypeptide binding]; other site 1249634006225 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 1249634006226 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1249634006227 DNA binding site [nucleotide binding] 1249634006228 domain linker motif; other site 1249634006229 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1249634006230 dimerization interface [polypeptide binding]; other site 1249634006231 ligand binding site [chemical binding]; other site 1249634006232 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1249634006233 Helix-turn-helix domain; Region: HTH_28; pfam13518 1249634006234 putative transposase OrfB; Reviewed; Region: PHA02517 1249634006235 Integrase core domain; Region: rve; pfam00665 1249634006236 Integrase core domain; Region: rve_3; pfam13683 1249634006237 superoxide dismutase; Provisional; Region: PRK10543 1249634006238 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1249634006239 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1249634006240 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1249634006241 NlpC/P60 family; Region: NLPC_P60; pfam00877 1249634006242 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1249634006243 putative GSH binding site [chemical binding]; other site 1249634006244 catalytic residues [active] 1249634006245 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1249634006246 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 1249634006247 dimer interface [polypeptide binding]; other site 1249634006248 catalytic site [active] 1249634006249 putative active site [active] 1249634006250 putative substrate binding site [chemical binding]; other site 1249634006251 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1249634006252 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1249634006253 dimer interface [polypeptide binding]; other site 1249634006254 active site 1249634006255 metal binding site [ion binding]; metal-binding site 1249634006256 glutathione binding site [chemical binding]; other site 1249634006257 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1249634006258 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1249634006259 FMN binding site [chemical binding]; other site 1249634006260 active site 1249634006261 substrate binding site [chemical binding]; other site 1249634006262 catalytic residue [active] 1249634006263 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1249634006264 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1249634006265 putative metal dependent hydrolase; Provisional; Region: PRK11598 1249634006266 Domain of unknown function (DUF4203); Region: DUF4203; pfam13886 1249634006267 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1249634006268 Sulfatase; Region: Sulfatase; pfam00884 1249634006269 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1249634006270 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1249634006271 NAD binding site [chemical binding]; other site 1249634006272 substrate binding site [chemical binding]; other site 1249634006273 putative active site [active] 1249634006274 transcriptional regulator; Provisional; Region: PRK10632 1249634006275 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634006276 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1249634006277 putative effector binding pocket; other site 1249634006278 dimerization interface [polypeptide binding]; other site 1249634006279 Predicted Fe-S protein [General function prediction only]; Region: COG3313 1249634006280 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1249634006281 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1249634006282 active site 1249634006283 catalytic tetrad [active] 1249634006284 Lipase (class 3); Region: Lipase_3; pfam01764 1249634006285 nucleophilic elbow; other site 1249634006286 catalytic triad; other site 1249634006287 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1249634006288 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1249634006289 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1249634006290 E-class dimer interface [polypeptide binding]; other site 1249634006291 P-class dimer interface [polypeptide binding]; other site 1249634006292 active site 1249634006293 Cu2+ binding site [ion binding]; other site 1249634006294 Zn2+ binding site [ion binding]; other site 1249634006295 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1249634006296 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1249634006297 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1249634006298 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1249634006299 HlyD family secretion protein; Region: HlyD_3; pfam13437 1249634006300 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 1249634006301 transcriptional regulator SlyA; Provisional; Region: PRK03573 1249634006302 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1249634006303 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 1249634006304 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1249634006305 lysozyme inhibitor; Provisional; Region: PRK11372 1249634006306 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1249634006307 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1249634006308 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1249634006309 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1249634006310 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1249634006311 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1249634006312 active site 1249634006313 HIGH motif; other site 1249634006314 dimer interface [polypeptide binding]; other site 1249634006315 KMSKS motif; other site 1249634006316 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1249634006317 RNA binding surface [nucleotide binding]; other site 1249634006318 pyridoxamine kinase; Validated; Region: PRK05756 1249634006319 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1249634006320 dimer interface [polypeptide binding]; other site 1249634006321 pyridoxal binding site [chemical binding]; other site 1249634006322 ATP binding site [chemical binding]; other site 1249634006323 glutathionine S-transferase; Provisional; Region: PRK10542 1249634006324 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1249634006325 C-terminal domain interface [polypeptide binding]; other site 1249634006326 GSH binding site (G-site) [chemical binding]; other site 1249634006327 dimer interface [polypeptide binding]; other site 1249634006328 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1249634006329 dimer interface [polypeptide binding]; other site 1249634006330 N-terminal domain interface [polypeptide binding]; other site 1249634006331 substrate binding pocket (H-site) [chemical binding]; other site 1249634006332 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1249634006333 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1249634006334 dimer interface [polypeptide binding]; other site 1249634006335 active site 1249634006336 catalytic residue [active] 1249634006337 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1249634006338 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1249634006339 homotrimer interaction site [polypeptide binding]; other site 1249634006340 putative active site [active] 1249634006341 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 1249634006342 Cupin domain; Region: Cupin_2; cl17218 1249634006343 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 1249634006344 benzoate transporter; Region: benE; TIGR00843 1249634006345 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1249634006346 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1249634006347 non-specific DNA binding site [nucleotide binding]; other site 1249634006348 salt bridge; other site 1249634006349 sequence-specific DNA binding site [nucleotide binding]; other site 1249634006350 Cupin domain; Region: Cupin_2; pfam07883 1249634006351 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1249634006352 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1249634006353 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1249634006354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634006355 putative substrate translocation pore; other site 1249634006356 POT family; Region: PTR2; pfam00854 1249634006357 endonuclease III; Provisional; Region: PRK10702 1249634006358 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1249634006359 minor groove reading motif; other site 1249634006360 helix-hairpin-helix signature motif; other site 1249634006361 substrate binding pocket [chemical binding]; other site 1249634006362 active site 1249634006363 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1249634006364 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1249634006365 electron transport complex protein RnfG; Validated; Region: PRK01908 1249634006366 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 1249634006367 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1249634006368 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634006369 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1249634006370 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 1249634006371 SLBB domain; Region: SLBB; pfam10531 1249634006372 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1249634006373 ferredoxin; Provisional; Region: PRK08764 1249634006374 Putative Fe-S cluster; Region: FeS; cl17515 1249634006375 4Fe-4S binding domain; Region: Fer4; cl02805 1249634006376 electron transport complex protein RsxA; Provisional; Region: PRK05151 1249634006377 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 1249634006378 carbon starvation protein A; Provisional; Region: PRK15015 1249634006379 Carbon starvation protein CstA; Region: CstA; pfam02554 1249634006380 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1249634006381 exoribonuclease II; Provisional; Region: PRK05054 1249634006382 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1249634006383 RNB domain; Region: RNB; pfam00773 1249634006384 S1 RNA binding domain; Region: S1; pfam00575 1249634006385 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1249634006386 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1249634006387 dimer interface [polypeptide binding]; other site 1249634006388 active site 1249634006389 metal binding site [ion binding]; metal-binding site 1249634006390 glutathione binding site [chemical binding]; other site 1249634006391 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1249634006392 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1249634006393 putative molybdopterin cofactor binding site [chemical binding]; other site 1249634006394 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1249634006395 putative molybdopterin cofactor binding site; other site 1249634006396 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 1249634006397 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1249634006398 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1249634006399 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634006400 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634006401 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1249634006402 dimerization interface [polypeptide binding]; other site 1249634006403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 1249634006404 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1249634006405 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 1249634006406 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1249634006407 Walker A/P-loop; other site 1249634006408 ATP binding site [chemical binding]; other site 1249634006409 Q-loop/lid; other site 1249634006410 ABC transporter signature motif; other site 1249634006411 Walker B; other site 1249634006412 D-loop; other site 1249634006413 H-loop/switch region; other site 1249634006414 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 1249634006415 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1249634006416 Walker A/P-loop; other site 1249634006417 ATP binding site [chemical binding]; other site 1249634006418 Q-loop/lid; other site 1249634006419 ABC transporter signature motif; other site 1249634006420 Walker B; other site 1249634006421 D-loop; other site 1249634006422 H-loop/switch region; other site 1249634006423 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1249634006424 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 1249634006425 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1249634006426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634006427 dimer interface [polypeptide binding]; other site 1249634006428 conserved gate region; other site 1249634006429 putative PBP binding loops; other site 1249634006430 ABC-ATPase subunit interface; other site 1249634006431 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 1249634006432 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634006433 putative PBP binding loops; other site 1249634006434 dimer interface [polypeptide binding]; other site 1249634006435 ABC-ATPase subunit interface; other site 1249634006436 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1249634006437 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1249634006438 peptide binding site [polypeptide binding]; other site 1249634006439 putative GTP cyclohydrolase; Provisional; Region: PRK13674 1249634006440 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 1249634006441 Fic/DOC family; Region: Fic; pfam02661 1249634006442 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1249634006443 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1249634006444 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634006445 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634006446 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1249634006447 dimerization interface [polypeptide binding]; other site 1249634006448 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 1249634006449 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1249634006450 Walker A motif; other site 1249634006451 ATP binding site [chemical binding]; other site 1249634006452 Walker B motif; other site 1249634006453 arginine finger; other site 1249634006454 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1249634006455 phage shock protein PspA; Provisional; Region: PRK10698 1249634006456 phage shock protein B; Provisional; Region: pspB; PRK09458 1249634006457 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 1249634006458 phage shock protein C; Region: phageshock_pspC; TIGR02978 1249634006459 Phage shock protein PspD (Phageshock_PspD); Region: Phageshock_PspD; cl11512 1249634006460 Predicted ATPase [General function prediction only]; Region: COG3106 1249634006461 hypothetical protein; Provisional; Region: PRK05415 1249634006462 Domain of unknown function (DUF697); Region: DUF697; cl12064 1249634006463 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 1249634006464 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 1249634006465 putative aromatic amino acid binding site; other site 1249634006466 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1249634006467 Walker A motif; other site 1249634006468 ATP binding site [chemical binding]; other site 1249634006469 Walker B motif; other site 1249634006470 arginine finger; other site 1249634006471 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1249634006472 dimer interface [polypeptide binding]; other site 1249634006473 catalytic triad [active] 1249634006474 peroxidatic and resolving cysteines [active] 1249634006475 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 1249634006476 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1249634006477 active site 1249634006478 murein peptide amidase A; Provisional; Region: PRK10602 1249634006479 active site 1249634006480 Zn binding site [ion binding]; other site 1249634006481 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1249634006482 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1249634006483 peptide binding site [polypeptide binding]; other site 1249634006484 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 1249634006485 NmrA-like family; Region: NmrA; pfam05368 1249634006486 NAD(P) binding site [chemical binding]; other site 1249634006487 active site lysine 1249634006488 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634006489 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634006490 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1249634006491 putative effector binding pocket; other site 1249634006492 putative dimerization interface [polypeptide binding]; other site 1249634006493 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1249634006494 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 1249634006495 Cl binding site [ion binding]; other site 1249634006496 oligomer interface [polypeptide binding]; other site 1249634006497 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1249634006498 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1249634006499 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1249634006500 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1249634006501 Ligand Binding Site [chemical binding]; other site 1249634006502 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1249634006503 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1249634006504 dimer interface [polypeptide binding]; other site 1249634006505 PYR/PP interface [polypeptide binding]; other site 1249634006506 TPP binding site [chemical binding]; other site 1249634006507 substrate binding site [chemical binding]; other site 1249634006508 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1249634006509 Domain of unknown function; Region: EKR; smart00890 1249634006510 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1249634006511 4Fe-4S binding domain; Region: Fer4; pfam00037 1249634006512 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1249634006513 TPP-binding site [chemical binding]; other site 1249634006514 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1249634006515 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 1249634006516 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1249634006517 heat-inducible protein; Provisional; Region: PRK10449 1249634006518 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 1249634006519 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1249634006520 putative ligand binding site [chemical binding]; other site 1249634006521 putative NAD binding site [chemical binding]; other site 1249634006522 catalytic site [active] 1249634006523 hypothetical protein; Provisional; Region: PRK10695 1249634006524 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 1249634006525 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 1249634006526 azoreductase; Reviewed; Region: PRK00170 1249634006527 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1249634006528 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1249634006529 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1249634006530 ATP binding site [chemical binding]; other site 1249634006531 putative Mg++ binding site [ion binding]; other site 1249634006532 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1249634006533 nucleotide binding region [chemical binding]; other site 1249634006534 ATP-binding site [chemical binding]; other site 1249634006535 Helicase associated domain (HA2); Region: HA2; pfam04408 1249634006536 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1249634006537 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1249634006538 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1249634006539 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1249634006540 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1249634006541 RbsD / FucU transport protein family; Region: RbsD_FucU; pfam05025 1249634006542 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1249634006543 classical (c) SDRs; Region: SDR_c; cd05233 1249634006544 NAD(P) binding site [chemical binding]; other site 1249634006545 active site 1249634006546 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1249634006547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634006548 putative substrate translocation pore; other site 1249634006549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634006550 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1249634006551 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1249634006552 DNA binding site [nucleotide binding] 1249634006553 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1249634006554 sensor protein RstB; Provisional; Region: PRK10604 1249634006555 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1249634006556 active site 1249634006557 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1249634006558 dimerization interface [polypeptide binding]; other site 1249634006559 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1249634006560 dimer interface [polypeptide binding]; other site 1249634006561 phosphorylation site [posttranslational modification] 1249634006562 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1249634006563 ATP binding site [chemical binding]; other site 1249634006564 Mg2+ binding site [ion binding]; other site 1249634006565 G-X-G motif; other site 1249634006566 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 1249634006567 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634006568 active site 1249634006569 phosphorylation site [posttranslational modification] 1249634006570 intermolecular recognition site; other site 1249634006571 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1249634006572 DNA binding site [nucleotide binding] 1249634006573 dihydromonapterin reductase; Provisional; Region: PRK06483 1249634006574 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1249634006575 NAD(P) binding site [chemical binding]; other site 1249634006576 active site 1249634006577 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1249634006578 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1249634006579 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1249634006580 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1249634006581 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 1249634006582 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1249634006583 ligand binding site [chemical binding]; other site 1249634006584 homodimer interface [polypeptide binding]; other site 1249634006585 NAD(P) binding site [chemical binding]; other site 1249634006586 trimer interface B [polypeptide binding]; other site 1249634006587 trimer interface A [polypeptide binding]; other site 1249634006588 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1249634006589 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 1249634006590 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1249634006591 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 1249634006592 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 1249634006593 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 1249634006594 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 1249634006595 universal stress protein UspE; Provisional; Region: PRK11175 1249634006596 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1249634006597 Ligand Binding Site [chemical binding]; other site 1249634006598 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1249634006599 Ligand Binding Site [chemical binding]; other site 1249634006600 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1249634006601 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1249634006602 ligand binding site [chemical binding]; other site 1249634006603 flexible hinge region; other site 1249634006604 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1249634006605 putative switch regulator; other site 1249634006606 non-specific DNA interactions [nucleotide binding]; other site 1249634006607 DNA binding site [nucleotide binding] 1249634006608 sequence specific DNA binding site [nucleotide binding]; other site 1249634006609 putative cAMP binding site [chemical binding]; other site 1249634006610 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 1249634006611 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1249634006612 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1249634006613 DNA binding site [nucleotide binding] 1249634006614 active site 1249634006615 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 1249634006616 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1249634006617 putative acyl-acceptor binding pocket; other site 1249634006618 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 1249634006619 Flagellar regulator YcgR; Region: YcgR; pfam07317 1249634006620 PilZ domain; Region: PilZ; pfam07238 1249634006621 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1249634006622 dimer interface [polypeptide binding]; other site 1249634006623 pyridoxal binding site [chemical binding]; other site 1249634006624 ATP binding site [chemical binding]; other site 1249634006625 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1249634006626 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1249634006627 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1249634006628 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634006629 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 1249634006630 putative dimerization interface [polypeptide binding]; other site 1249634006631 putative substrate binding pocket [chemical binding]; other site 1249634006632 Chromate transporter; Region: Chromate_transp; pfam02417 1249634006633 Chromate transporter; Region: Chromate_transp; pfam02417 1249634006634 RibD C-terminal domain; Region: RibD_C; cl17279 1249634006635 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1249634006636 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 1249634006637 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1249634006638 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1249634006639 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1249634006640 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634006641 homodimer interface [polypeptide binding]; other site 1249634006642 catalytic residue [active] 1249634006643 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1249634006644 EamA-like transporter family; Region: EamA; pfam00892 1249634006645 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634006646 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1249634006647 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634006648 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1249634006649 HlyD family secretion protein; Region: HlyD_3; pfam13437 1249634006650 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1249634006651 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1249634006652 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1249634006653 Walker A/P-loop; other site 1249634006654 ATP binding site [chemical binding]; other site 1249634006655 Q-loop/lid; other site 1249634006656 ABC transporter signature motif; other site 1249634006657 Walker B; other site 1249634006658 D-loop; other site 1249634006659 H-loop/switch region; other site 1249634006660 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1249634006661 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1249634006662 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1249634006663 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1249634006664 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1249634006665 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1249634006666 Hemolysin-type calcium-binding repeat (2 copies); Region: HemolysinCabind; pfam00353 1249634006667 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1249634006668 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 1249634006669 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 1249634006670 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1249634006671 active site 1249634006672 motif I; other site 1249634006673 motif II; other site 1249634006674 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 1249634006675 penicillin-binding protein 2; Provisional; Region: PRK10795 1249634006676 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1249634006677 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1249634006678 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1249634006679 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1249634006680 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1249634006681 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634006682 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634006683 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1249634006684 dimerization interface [polypeptide binding]; other site 1249634006685 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1249634006686 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1249634006687 metal binding site [ion binding]; metal-binding site 1249634006688 putative dimer interface [polypeptide binding]; other site 1249634006689 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634006690 metabolite-proton symporter; Region: 2A0106; TIGR00883 1249634006691 putative substrate translocation pore; other site 1249634006692 Rrf2 family protein; Region: rrf2_super; TIGR00738 1249634006693 Transcriptional regulator; Region: Rrf2; pfam02082 1249634006694 Transcriptional regulator; Region: Rrf2; cl17282 1249634006695 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 1249634006696 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1249634006697 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1249634006698 HlyD family secretion protein; Region: HlyD_3; pfam13437 1249634006699 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1249634006700 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 1249634006701 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 1249634006702 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1249634006703 dimer interface [polypeptide binding]; other site 1249634006704 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1249634006705 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1249634006706 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1249634006707 catalytic residue [active] 1249634006708 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1249634006709 dimer interface [polypeptide binding]; other site 1249634006710 FMN binding site [chemical binding]; other site 1249634006711 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458 1249634006712 Putative bacterial virulence factor; Region: Virul_Fac; pfam10139 1249634006713 Virulence factor SrfB; Region: SrfB; pfam07520 1249634006714 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634006715 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634006716 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 1249634006717 putative substrate binding pocket [chemical binding]; other site 1249634006718 putative dimerization interface [polypeptide binding]; other site 1249634006719 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1249634006720 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1249634006721 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1249634006722 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1249634006723 NAD(P) binding site [chemical binding]; other site 1249634006724 active site 1249634006725 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1249634006726 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1249634006727 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 1249634006728 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1249634006729 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1249634006730 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1249634006731 dimer interface [polypeptide binding]; other site 1249634006732 active site 1249634006733 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1249634006734 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1249634006735 active site 1249634006736 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1249634006737 active site 1249634006738 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1249634006739 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1249634006740 Walker A/P-loop; other site 1249634006741 ATP binding site [chemical binding]; other site 1249634006742 Q-loop/lid; other site 1249634006743 ABC transporter signature motif; other site 1249634006744 Walker B; other site 1249634006745 D-loop; other site 1249634006746 H-loop/switch region; other site 1249634006747 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1249634006748 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1249634006749 FtsX-like permease family; Region: FtsX; pfam02687 1249634006750 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 1249634006751 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 1249634006752 putative NAD(P) binding site [chemical binding]; other site 1249634006753 active site 1249634006754 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1249634006755 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1249634006756 von Willebrand factor type D domain; Region: VWD; cl02516 1249634006757 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1249634006758 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1249634006759 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1249634006760 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1249634006761 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1249634006762 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1249634006763 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1249634006764 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1249634006765 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1249634006766 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1249634006767 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 1249634006768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634006769 putative substrate translocation pore; other site 1249634006770 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1249634006771 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1249634006772 tetramerization interface [polypeptide binding]; other site 1249634006773 NAD(P) binding site [chemical binding]; other site 1249634006774 catalytic residues [active] 1249634006775 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1249634006776 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1249634006777 potential catalytic triad [active] 1249634006778 conserved cys residue [active] 1249634006779 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1249634006780 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634006781 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1249634006782 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634006783 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1249634006784 elongation factor G; Reviewed; Region: PRK00007 1249634006785 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1249634006786 G1 box; other site 1249634006787 putative GEF interaction site [polypeptide binding]; other site 1249634006788 GTP/Mg2+ binding site [chemical binding]; other site 1249634006789 Switch I region; other site 1249634006790 G2 box; other site 1249634006791 G3 box; other site 1249634006792 Switch II region; other site 1249634006793 G4 box; other site 1249634006794 G5 box; other site 1249634006795 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1249634006796 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1249634006797 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1249634006798 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 1249634006799 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 1249634006800 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1249634006801 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1249634006802 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 1249634006803 active site turn [active] 1249634006804 phosphorylation site [posttranslational modification] 1249634006805 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634006806 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634006807 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1249634006808 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1249634006809 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1249634006810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634006811 dimer interface [polypeptide binding]; other site 1249634006812 conserved gate region; other site 1249634006813 putative PBP binding loops; other site 1249634006814 ABC-ATPase subunit interface; other site 1249634006815 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1249634006816 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634006817 dimer interface [polypeptide binding]; other site 1249634006818 conserved gate region; other site 1249634006819 putative PBP binding loops; other site 1249634006820 ABC-ATPase subunit interface; other site 1249634006821 alpha-galactosidase; Provisional; Region: PRK15076 1249634006822 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1249634006823 NAD(P) binding site [chemical binding]; other site 1249634006824 LDH/MDH dimer interface [polypeptide binding]; other site 1249634006825 substrate binding site [chemical binding]; other site 1249634006826 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1249634006827 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1249634006828 Walker A/P-loop; other site 1249634006829 ATP binding site [chemical binding]; other site 1249634006830 Q-loop/lid; other site 1249634006831 ABC transporter signature motif; other site 1249634006832 Walker B; other site 1249634006833 D-loop; other site 1249634006834 H-loop/switch region; other site 1249634006835 TOBE domain; Region: TOBE_2; pfam08402 1249634006836 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1249634006837 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1249634006838 Ca binding site [ion binding]; other site 1249634006839 active site 1249634006840 catalytic site [active] 1249634006841 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1249634006842 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1249634006843 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1249634006844 haloalkane dehalogenase; Provisional; Region: PRK03592 1249634006845 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1249634006846 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1249634006847 active site 1249634006848 catalytic site [active] 1249634006849 LysR family transcriptional regulator; Provisional; Region: PRK14997 1249634006850 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634006851 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 1249634006852 putative effector binding pocket; other site 1249634006853 putative dimerization interface [polypeptide binding]; other site 1249634006854 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1249634006855 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1249634006856 NAD(P) binding site [chemical binding]; other site 1249634006857 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 1249634006858 MerC mercury resistance protein; Region: MerC; pfam03203 1249634006859 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1249634006860 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1249634006861 Trp docking motif [polypeptide binding]; other site 1249634006862 putative active site [active] 1249634006863 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 1249634006864 coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110 1249634006865 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1249634006866 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 1249634006867 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1249634006868 FeS/SAM binding site; other site 1249634006869 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1249634006870 pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079 1249634006871 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 1249634006872 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 1249634006873 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 1249634006874 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 1249634006875 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1249634006876 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1249634006877 active site 1249634006878 dimer interface [polypeptide binding]; other site 1249634006879 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1249634006880 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1249634006881 Trp docking motif [polypeptide binding]; other site 1249634006882 putative active site [active] 1249634006883 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 1249634006884 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1249634006885 proline/glycine betaine transporter; Provisional; Region: PRK10642 1249634006886 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634006887 putative substrate translocation pore; other site 1249634006888 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1249634006889 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1249634006890 putative DNA binding site [nucleotide binding]; other site 1249634006891 putative Zn2+ binding site [ion binding]; other site 1249634006892 AsnC family; Region: AsnC_trans_reg; pfam01037 1249634006893 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 1249634006894 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 1249634006895 putative active site [active] 1249634006896 Zn binding site [ion binding]; other site 1249634006897 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 1249634006898 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1249634006899 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1249634006900 active site 1249634006901 ectoine utilization protein EutC; Validated; Region: PRK08291 1249634006902 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1249634006903 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1249634006904 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1249634006905 tetramer interface [polypeptide binding]; other site 1249634006906 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634006907 catalytic residue [active] 1249634006908 hypothetical protein; Provisional; Region: PRK07482 1249634006909 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1249634006910 inhibitor-cofactor binding pocket; inhibition site 1249634006911 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634006912 catalytic residue [active] 1249634006913 succinic semialdehyde dehydrogenase; Region: PLN02278 1249634006914 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1249634006915 tetramerization interface [polypeptide binding]; other site 1249634006916 NAD(P) binding site [chemical binding]; other site 1249634006917 catalytic residues [active] 1249634006918 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1249634006919 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1249634006920 putative NAD(P) binding site [chemical binding]; other site 1249634006921 putative substrate binding site [chemical binding]; other site 1249634006922 catalytic Zn binding site [ion binding]; other site 1249634006923 structural Zn binding site [ion binding]; other site 1249634006924 dimer interface [polypeptide binding]; other site 1249634006925 Predicted transcriptional regulators [Transcription]; Region: COG1733 1249634006926 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1249634006927 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1249634006928 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1249634006929 catalytic residue [active] 1249634006930 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 1249634006931 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1249634006932 inhibitor-cofactor binding pocket; inhibition site 1249634006933 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634006934 catalytic residue [active] 1249634006935 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1249634006936 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1249634006937 metal binding site [ion binding]; metal-binding site 1249634006938 active site 1249634006939 I-site; other site 1249634006940 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 1249634006941 nudix motif; other site 1249634006942 short chain dehydrogenase; Provisional; Region: PRK06500 1249634006943 classical (c) SDRs; Region: SDR_c; cd05233 1249634006944 NAD(P) binding site [chemical binding]; other site 1249634006945 active site 1249634006946 Predicted transcriptional regulators [Transcription]; Region: COG1733 1249634006947 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1249634006948 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1249634006949 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1249634006950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634006951 metabolite-proton symporter; Region: 2A0106; TIGR00883 1249634006952 putative substrate translocation pore; other site 1249634006953 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 1249634006954 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 1249634006955 NAD binding site [chemical binding]; other site 1249634006956 catalytic Zn binding site [ion binding]; other site 1249634006957 structural Zn binding site [ion binding]; other site 1249634006958 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1249634006959 Coenzyme A binding pocket [chemical binding]; other site 1249634006960 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1249634006961 GlpM protein; Region: GlpM; pfam06942 1249634006962 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1249634006963 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634006964 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1249634006965 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634006966 short chain dehydrogenase; Provisional; Region: PRK06180 1249634006967 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1249634006968 NADP binding site [chemical binding]; other site 1249634006969 active site 1249634006970 steroid binding site; other site 1249634006971 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1249634006972 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1249634006973 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1249634006974 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1249634006975 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1249634006976 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1249634006977 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1249634006978 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634006979 active site 1249634006980 phosphorylation site [posttranslational modification] 1249634006981 intermolecular recognition site; other site 1249634006982 dimerization interface [polypeptide binding]; other site 1249634006983 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1249634006984 DNA binding site [nucleotide binding] 1249634006985 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1249634006986 dimerization interface [polypeptide binding]; other site 1249634006987 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1249634006988 dimer interface [polypeptide binding]; other site 1249634006989 phosphorylation site [posttranslational modification] 1249634006990 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1249634006991 ATP binding site [chemical binding]; other site 1249634006992 Mg2+ binding site [ion binding]; other site 1249634006993 G-X-G motif; other site 1249634006994 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1249634006995 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1249634006996 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1249634006997 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1249634006998 conserved cys residue [active] 1249634006999 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634007000 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1249634007001 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1249634007002 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1249634007003 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1249634007004 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1249634007005 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1249634007006 DNA binding residues [nucleotide binding] 1249634007007 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1249634007008 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 1249634007009 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 1249634007010 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1249634007011 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 1249634007012 putative active site [active] 1249634007013 putative FMN binding site [chemical binding]; other site 1249634007014 putative substrate binding site [chemical binding]; other site 1249634007015 putative catalytic residue [active] 1249634007016 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1249634007017 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1249634007018 DNA binding residues [nucleotide binding] 1249634007019 short chain dehydrogenase; Provisional; Region: PRK12937 1249634007020 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1249634007021 NADP binding site [chemical binding]; other site 1249634007022 homodimer interface [polypeptide binding]; other site 1249634007023 active site 1249634007024 substrate binding site [chemical binding]; other site 1249634007025 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 1249634007026 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634007027 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634007028 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1249634007029 substrate binding pocket [chemical binding]; other site 1249634007030 dimerization interface [polypeptide binding]; other site 1249634007031 enoyl-CoA hydratase; Provisional; Region: PRK06494 1249634007032 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1249634007033 substrate binding site [chemical binding]; other site 1249634007034 oxyanion hole (OAH) forming residues; other site 1249634007035 trimer interface [polypeptide binding]; other site 1249634007036 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1249634007037 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1249634007038 substrate binding site [chemical binding]; other site 1249634007039 oxyanion hole (OAH) forming residues; other site 1249634007040 trimer interface [polypeptide binding]; other site 1249634007041 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1249634007042 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1249634007043 substrate binding site [chemical binding]; other site 1249634007044 oxyanion hole (OAH) forming residues; other site 1249634007045 trimer interface [polypeptide binding]; other site 1249634007046 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1249634007047 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1249634007048 malonyl-CoA binding site [chemical binding]; other site 1249634007049 dimer interface [polypeptide binding]; other site 1249634007050 active site 1249634007051 product binding site; other site 1249634007052 aspartate aminotransferase; Provisional; Region: PRK06348 1249634007053 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1249634007054 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634007055 homodimer interface [polypeptide binding]; other site 1249634007056 catalytic residue [active] 1249634007057 hypothetical protein; Provisional; Region: PRK07206 1249634007058 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1249634007059 sugar efflux transporter; Region: 2A0120; TIGR00899 1249634007060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634007061 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1249634007062 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634007063 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1249634007064 dimerization interface [polypeptide binding]; other site 1249634007065 substrate binding pocket [chemical binding]; other site 1249634007066 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1249634007067 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1249634007068 NAD(P) binding site [chemical binding]; other site 1249634007069 active site 1249634007070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634007071 D-galactonate transporter; Region: 2A0114; TIGR00893 1249634007072 putative substrate translocation pore; other site 1249634007073 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1249634007074 TPP-binding site [chemical binding]; other site 1249634007075 dimer interface [polypeptide binding]; other site 1249634007076 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1249634007077 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1249634007078 PYR/PP interface [polypeptide binding]; other site 1249634007079 dimer interface [polypeptide binding]; other site 1249634007080 TPP binding site [chemical binding]; other site 1249634007081 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1249634007082 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1249634007083 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1249634007084 dimerization interface [polypeptide binding]; other site 1249634007085 putative DNA binding site [nucleotide binding]; other site 1249634007086 putative Zn2+ binding site [ion binding]; other site 1249634007087 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 1249634007088 putative hydrophobic ligand binding site [chemical binding]; other site 1249634007089 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1249634007090 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634007091 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1249634007092 dimerization interface [polypeptide binding]; other site 1249634007093 substrate binding pocket [chemical binding]; other site 1249634007094 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1249634007095 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1249634007096 putative NAD(P) binding site [chemical binding]; other site 1249634007097 putative active site [active] 1249634007098 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 1249634007099 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1249634007100 active site 1249634007101 Zn binding site [ion binding]; other site 1249634007102 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1249634007103 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 1249634007104 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1249634007105 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 1249634007106 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1249634007107 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1249634007108 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 1249634007109 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1249634007110 catalytic loop [active] 1249634007111 iron binding site [ion binding]; other site 1249634007112 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1249634007113 FAD binding domain; Region: FAD_binding_4; pfam01565 1249634007114 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1249634007115 guanine deaminase; Provisional; Region: PRK09228 1249634007116 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 1249634007117 active site 1249634007118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634007119 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1249634007120 putative substrate translocation pore; other site 1249634007121 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1249634007122 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1249634007123 Coenzyme A binding pocket [chemical binding]; other site 1249634007124 malonic semialdehyde reductase; Provisional; Region: PRK10538 1249634007125 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1249634007126 putative NAD(P) binding site [chemical binding]; other site 1249634007127 homodimer interface [polypeptide binding]; other site 1249634007128 homotetramer interface [polypeptide binding]; other site 1249634007129 active site 1249634007130 hypothetical protein; Provisional; Region: PRK02237 1249634007131 hypothetical protein; Provisional; Region: PRK13659 1249634007132 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 1249634007133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634007134 putative substrate translocation pore; other site 1249634007135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634007136 dimer interface [polypeptide binding]; other site 1249634007137 conserved gate region; other site 1249634007138 putative PBP binding loops; other site 1249634007139 ABC-ATPase subunit interface; other site 1249634007140 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1249634007141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634007142 dimer interface [polypeptide binding]; other site 1249634007143 conserved gate region; other site 1249634007144 ABC-ATPase subunit interface; other site 1249634007145 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1249634007146 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1249634007147 Walker A/P-loop; other site 1249634007148 ATP binding site [chemical binding]; other site 1249634007149 Q-loop/lid; other site 1249634007150 ABC transporter signature motif; other site 1249634007151 Walker B; other site 1249634007152 D-loop; other site 1249634007153 H-loop/switch region; other site 1249634007154 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 1249634007155 Haem-binding domain; Region: Haem_bd; pfam14376 1249634007156 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 1249634007157 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1249634007158 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1249634007159 Cl- selectivity filter; other site 1249634007160 Cl- binding residues [ion binding]; other site 1249634007161 pore gating glutamate residue; other site 1249634007162 dimer interface [polypeptide binding]; other site 1249634007163 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1249634007164 AAA domain; Region: AAA_26; pfam13500 1249634007165 MarR family; Region: MarR_2; cl17246 1249634007166 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1249634007167 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1249634007168 nucleotide binding site [chemical binding]; other site 1249634007169 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1249634007170 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634007171 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1249634007172 dimerization interface [polypeptide binding]; other site 1249634007173 substrate binding pocket [chemical binding]; other site 1249634007174 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1249634007175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634007176 putative substrate translocation pore; other site 1249634007177 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 1249634007178 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1249634007179 Class II fumarases; Region: Fumarase_classII; cd01362 1249634007180 active site 1249634007181 tetramer interface [polypeptide binding]; other site 1249634007182 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1249634007183 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1249634007184 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1249634007185 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 1249634007186 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 1249634007187 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 1249634007188 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1249634007189 DNA binding site [nucleotide binding] 1249634007190 domain linker motif; other site 1249634007191 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1249634007192 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 1249634007193 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1249634007194 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1249634007195 active site turn [active] 1249634007196 phosphorylation site [posttranslational modification] 1249634007197 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1249634007198 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1249634007199 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634007200 homodimer interface [polypeptide binding]; other site 1249634007201 catalytic residue [active] 1249634007202 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1249634007203 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1249634007204 dimer interface [polypeptide binding]; other site 1249634007205 ADP-ribose binding site [chemical binding]; other site 1249634007206 active site 1249634007207 nudix motif; other site 1249634007208 metal binding site [ion binding]; metal-binding site 1249634007209 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1249634007210 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1249634007211 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1249634007212 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1249634007213 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1249634007214 active site 1249634007215 purine riboside binding site [chemical binding]; other site 1249634007216 C factor cell-cell signaling protein; Provisional; Region: PRK09009 1249634007217 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1249634007218 NAD(P) binding site [chemical binding]; other site 1249634007219 active site 1249634007220 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634007221 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634007222 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 1249634007223 putative substrate binding pocket [chemical binding]; other site 1249634007224 putative dimerization interface [polypeptide binding]; other site 1249634007225 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1249634007226 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1249634007227 putative oxidoreductase; Provisional; Region: PRK11579 1249634007228 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1249634007229 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1249634007230 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 1249634007231 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1249634007232 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634007233 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634007234 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1249634007235 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1249634007236 TM-ABC transporter signature motif; other site 1249634007237 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 1249634007238 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1249634007239 Walker A/P-loop; other site 1249634007240 ATP binding site [chemical binding]; other site 1249634007241 Q-loop/lid; other site 1249634007242 ABC transporter signature motif; other site 1249634007243 Walker B; other site 1249634007244 D-loop; other site 1249634007245 H-loop/switch region; other site 1249634007246 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1249634007247 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1249634007248 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 1249634007249 ligand binding site [chemical binding]; other site 1249634007250 ribulokinase; Provisional; Region: PRK04123 1249634007251 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1249634007252 N- and C-terminal domain interface [polypeptide binding]; other site 1249634007253 active site 1249634007254 MgATP binding site [chemical binding]; other site 1249634007255 catalytic site [active] 1249634007256 metal binding site [ion binding]; metal-binding site 1249634007257 carbohydrate binding site [chemical binding]; other site 1249634007258 homodimer interface [polypeptide binding]; other site 1249634007259 L-arabinose isomerase; Provisional; Region: PRK02929 1249634007260 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1249634007261 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1249634007262 trimer interface [polypeptide binding]; other site 1249634007263 putative substrate binding site [chemical binding]; other site 1249634007264 putative metal binding site [ion binding]; other site 1249634007265 2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793 1249634007266 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1249634007267 active site 1249634007268 intersubunit interactions; other site 1249634007269 catalytic residue [active] 1249634007270 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1249634007271 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1249634007272 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1249634007273 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1249634007274 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1249634007275 intersubunit interface [polypeptide binding]; other site 1249634007276 active site 1249634007277 Zn2+ binding site [ion binding]; other site 1249634007278 lipoprotein; Provisional; Region: PRK10540 1249634007279 translation initiation factor Sui1; Validated; Region: PRK06824 1249634007280 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1249634007281 putative rRNA binding site [nucleotide binding]; other site 1249634007282 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1249634007283 active site 1249634007284 dimer interface [polypeptide binding]; other site 1249634007285 tetratricopeptide repeat protein; Provisional; Region: PRK11788 1249634007286 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1249634007287 binding surface 1249634007288 TPR motif; other site 1249634007289 Predicted membrane protein [Function unknown]; Region: COG3771 1249634007290 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1249634007291 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1249634007292 active site 1249634007293 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1249634007294 dimerization interface [polypeptide binding]; other site 1249634007295 active site 1249634007296 aconitate hydratase; Validated; Region: PRK09277 1249634007297 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1249634007298 substrate binding site [chemical binding]; other site 1249634007299 ligand binding site [chemical binding]; other site 1249634007300 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1249634007301 substrate binding site [chemical binding]; other site 1249634007302 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 1249634007303 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634007304 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 1249634007305 substrate binding site [chemical binding]; other site 1249634007306 putative dimerization interface [polypeptide binding]; other site 1249634007307 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1249634007308 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1249634007309 active site 1249634007310 interdomain interaction site; other site 1249634007311 putative metal-binding site [ion binding]; other site 1249634007312 nucleotide binding site [chemical binding]; other site 1249634007313 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1249634007314 domain I; other site 1249634007315 DNA binding groove [nucleotide binding] 1249634007316 phosphate binding site [ion binding]; other site 1249634007317 domain II; other site 1249634007318 domain III; other site 1249634007319 nucleotide binding site [chemical binding]; other site 1249634007320 catalytic site [active] 1249634007321 domain IV; other site 1249634007322 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1249634007323 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1249634007324 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1249634007325 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1249634007326 hypothetical protein; Provisional; Region: PRK11037 1249634007327 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 1249634007328 putative inner membrane peptidase; Provisional; Region: PRK11778 1249634007329 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1249634007330 tandem repeat interface [polypeptide binding]; other site 1249634007331 oligomer interface [polypeptide binding]; other site 1249634007332 active site residues [active] 1249634007333 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 1249634007334 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 1249634007335 NADP binding site [chemical binding]; other site 1249634007336 homodimer interface [polypeptide binding]; other site 1249634007337 active site 1249634007338 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1249634007339 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 1249634007340 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1249634007341 homodimer interface [polypeptide binding]; other site 1249634007342 Walker A motif; other site 1249634007343 ATP binding site [chemical binding]; other site 1249634007344 hydroxycobalamin binding site [chemical binding]; other site 1249634007345 Walker B motif; other site 1249634007346 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 1249634007347 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1249634007348 RNA binding surface [nucleotide binding]; other site 1249634007349 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1249634007350 probable active site [active] 1249634007351 hypothetical protein; Provisional; Region: PRK11630 1249634007352 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1249634007353 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1249634007354 active site 1249634007355 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1249634007356 Tryptophan operon leader; D781_2416; IMG reference gene:2517283806 1249634007357 anthranilate synthase component I; Provisional; Region: PRK13564 1249634007358 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1249634007359 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1249634007360 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1249634007361 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1249634007362 glutamine binding [chemical binding]; other site 1249634007363 catalytic triad [active] 1249634007364 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1249634007365 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1249634007366 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1249634007367 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 1249634007368 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1249634007369 active site 1249634007370 ribulose/triose binding site [chemical binding]; other site 1249634007371 phosphate binding site [ion binding]; other site 1249634007372 substrate (anthranilate) binding pocket [chemical binding]; other site 1249634007373 product (indole) binding pocket [chemical binding]; other site 1249634007374 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1249634007375 active site 1249634007376 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1249634007377 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1249634007378 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634007379 catalytic residue [active] 1249634007380 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1249634007381 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1249634007382 substrate binding site [chemical binding]; other site 1249634007383 active site 1249634007384 catalytic residues [active] 1249634007385 heterodimer interface [polypeptide binding]; other site 1249634007386 Photosystem II Pbs27; Region: PSII_Pbs27; cl11841 1249634007387 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1249634007388 BON domain; Region: BON; pfam04972 1249634007389 outer membrane protein W; Provisional; Region: PRK10959 1249634007390 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 1249634007391 hypothetical protein; Provisional; Region: PRK02868 1249634007392 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1249634007393 Helix-turn-helix domain; Region: HTH_28; pfam13518 1249634007394 putative transposase OrfB; Reviewed; Region: PHA02517 1249634007395 Integrase core domain; Region: rve; pfam00665 1249634007396 Integrase core domain; Region: rve_3; pfam13683 1249634007397 intracellular septation protein A; Reviewed; Region: PRK00259 1249634007398 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1249634007399 transport protein TonB; Provisional; Region: PRK10819 1249634007400 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1249634007401 2-isopropylmalate synthase; Validated; Region: PRK03739 1249634007402 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1249634007403 active site 1249634007404 catalytic residues [active] 1249634007405 metal binding site [ion binding]; metal-binding site 1249634007406 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1249634007407 Cupin domain; Region: Cupin_2; cl17218 1249634007408 Helix-turn-helix domain; Region: HTH_18; pfam12833 1249634007409 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634007410 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 1249634007411 YciI-like protein; Reviewed; Region: PRK11370 1249634007412 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1249634007413 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1249634007414 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1249634007415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634007416 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1249634007417 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1249634007418 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 1249634007419 putative active site [active] 1249634007420 catalytic site [active] 1249634007421 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 1249634007422 putative active site [active] 1249634007423 catalytic site [active] 1249634007424 dsDNA-mimic protein; Reviewed; Region: PRK05094 1249634007425 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1249634007426 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1249634007427 Walker A/P-loop; other site 1249634007428 ATP binding site [chemical binding]; other site 1249634007429 Q-loop/lid; other site 1249634007430 ABC transporter signature motif; other site 1249634007431 Walker B; other site 1249634007432 D-loop; other site 1249634007433 H-loop/switch region; other site 1249634007434 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1249634007435 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 1249634007436 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1249634007437 Walker A/P-loop; other site 1249634007438 ATP binding site [chemical binding]; other site 1249634007439 Q-loop/lid; other site 1249634007440 ABC transporter signature motif; other site 1249634007441 Walker B; other site 1249634007442 D-loop; other site 1249634007443 H-loop/switch region; other site 1249634007444 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1249634007445 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1249634007446 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1249634007447 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634007448 dimer interface [polypeptide binding]; other site 1249634007449 conserved gate region; other site 1249634007450 ABC-ATPase subunit interface; other site 1249634007451 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1249634007452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634007453 dimer interface [polypeptide binding]; other site 1249634007454 conserved gate region; other site 1249634007455 putative PBP binding loops; other site 1249634007456 ABC-ATPase subunit interface; other site 1249634007457 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1249634007458 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1249634007459 peptide binding site [polypeptide binding]; other site 1249634007460 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1249634007461 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1249634007462 peptide binding site [polypeptide binding]; other site 1249634007463 hypothetical protein; Provisional; Region: PRK11111 1249634007464 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1249634007465 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1249634007466 putative catalytic cysteine [active] 1249634007467 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1249634007468 putative active site [active] 1249634007469 metal binding site [ion binding]; metal-binding site 1249634007470 thymidine kinase; Provisional; Region: PRK04296 1249634007471 Uncharacterized conserved protein (DUF2217); Region: DUF2217; pfam10265 1249634007472 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 1249634007473 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1249634007474 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1249634007475 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 1249634007476 putative NAD(P) binding site [chemical binding]; other site 1249634007477 active site 1249634007478 putative substrate binding site [chemical binding]; other site 1249634007479 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1249634007480 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1249634007481 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1249634007482 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1249634007483 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1249634007484 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1249634007485 active site 1249634007486 tetramer interface; other site 1249634007487 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634007488 active site 1249634007489 response regulator of RpoS; Provisional; Region: PRK10693 1249634007490 phosphorylation site [posttranslational modification] 1249634007491 intermolecular recognition site; other site 1249634007492 dimerization interface [polypeptide binding]; other site 1249634007493 hypothetical protein; Provisional; Region: PRK10279 1249634007494 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1249634007495 active site 1249634007496 nucleophile elbow; other site 1249634007497 SEC-C motif; Region: SEC-C; pfam02810 1249634007498 hypothetical protein; Provisional; Region: PRK04233 1249634007499 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1249634007500 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1249634007501 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1249634007502 putative active site [active] 1249634007503 putative substrate binding site [chemical binding]; other site 1249634007504 putative cosubstrate binding site; other site 1249634007505 catalytic site [active] 1249634007506 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1249634007507 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1249634007508 putative catalytic site [active] 1249634007509 putative phosphate binding site [ion binding]; other site 1249634007510 active site 1249634007511 metal binding site A [ion binding]; metal-binding site 1249634007512 DNA binding site [nucleotide binding] 1249634007513 putative AP binding site [nucleotide binding]; other site 1249634007514 putative metal binding site B [ion binding]; other site 1249634007515 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1249634007516 active site 1249634007517 8-oxo-dGMP binding site [chemical binding]; other site 1249634007518 nudix motif; other site 1249634007519 metal binding site [ion binding]; metal-binding site 1249634007520 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 1249634007521 DNA topoisomerase III; Provisional; Region: PRK07726 1249634007522 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1249634007523 active site 1249634007524 putative interdomain interaction site [polypeptide binding]; other site 1249634007525 putative metal-binding site [ion binding]; other site 1249634007526 putative nucleotide binding site [chemical binding]; other site 1249634007527 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1249634007528 domain I; other site 1249634007529 DNA binding groove [nucleotide binding] 1249634007530 phosphate binding site [ion binding]; other site 1249634007531 domain II; other site 1249634007532 domain III; other site 1249634007533 nucleotide binding site [chemical binding]; other site 1249634007534 catalytic site [active] 1249634007535 domain IV; other site 1249634007536 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 1249634007537 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 1249634007538 active site residue [active] 1249634007539 selenophosphate synthetase; Provisional; Region: PRK00943 1249634007540 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1249634007541 dimerization interface [polypeptide binding]; other site 1249634007542 putative ATP binding site [chemical binding]; other site 1249634007543 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1249634007544 putative FMN binding site [chemical binding]; other site 1249634007545 protease 4; Provisional; Region: PRK10949 1249634007546 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1249634007547 tandem repeat interface [polypeptide binding]; other site 1249634007548 oligomer interface [polypeptide binding]; other site 1249634007549 active site residues [active] 1249634007550 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 1249634007551 tandem repeat interface [polypeptide binding]; other site 1249634007552 oligomer interface [polypeptide binding]; other site 1249634007553 active site residues [active] 1249634007554 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1249634007555 active site 1249634007556 homodimer interface [polypeptide binding]; other site 1249634007557 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1249634007558 Isochorismatase family; Region: Isochorismatase; pfam00857 1249634007559 catalytic triad [active] 1249634007560 metal binding site [ion binding]; metal-binding site 1249634007561 conserved cis-peptide bond; other site 1249634007562 Protein of unknown function (DUF1315); Region: DUF1315; pfam07023 1249634007563 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1249634007564 SelR domain; Region: SelR; pfam01641 1249634007565 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 1249634007566 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1249634007567 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1249634007568 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1249634007569 active site 1249634007570 phosphate binding residues; other site 1249634007571 catalytic residues [active] 1249634007572 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1249634007573 PrkA family serine protein kinase; Provisional; Region: PRK15455 1249634007574 AAA ATPase domain; Region: AAA_16; pfam13191 1249634007575 Walker A motif; other site 1249634007576 ATP binding site [chemical binding]; other site 1249634007577 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1249634007578 hypothetical protein; Provisional; Region: PRK05325 1249634007579 Proteolipid membrane potential modulator; Region: Pmp3; cl00431 1249634007580 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 1249634007581 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1249634007582 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1249634007583 N-terminal plug; other site 1249634007584 ligand-binding site [chemical binding]; other site 1249634007585 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1249634007586 active site 1249634007587 substrate binding site [chemical binding]; other site 1249634007588 catalytic site [active] 1249634007589 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634007590 putative substrate translocation pore; other site 1249634007591 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1249634007592 alanine racemase; Reviewed; Region: dadX; PRK03646 1249634007593 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1249634007594 active site 1249634007595 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1249634007596 substrate binding site [chemical binding]; other site 1249634007597 catalytic residues [active] 1249634007598 dimer interface [polypeptide binding]; other site 1249634007599 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1249634007600 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1249634007601 SpoVR family protein; Provisional; Region: PRK11767 1249634007602 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1249634007603 fatty acid metabolism regulator; Provisional; Region: PRK04984 1249634007604 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1249634007605 DNA-binding site [nucleotide binding]; DNA binding site 1249634007606 FadR C-terminal domain; Region: FadR_C; pfam07840 1249634007607 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 1249634007608 disulfide bond formation protein B; Provisional; Region: PRK01749 1249634007609 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1249634007610 FeS/SAM binding site; other site 1249634007611 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 1249634007612 hypothetical protein; Provisional; Region: PRK05170 1249634007613 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1249634007614 hypothetical protein; Provisional; Region: PRK10691 1249634007615 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1249634007616 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1249634007617 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1249634007618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 1249634007619 septum formation inhibitor; Reviewed; Region: minC; PRK03511 1249634007620 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1249634007621 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1249634007622 cell division inhibitor MinD; Provisional; Region: PRK10818 1249634007623 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1249634007624 Switch I; other site 1249634007625 Switch II; other site 1249634007626 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1249634007627 ribonuclease D; Provisional; Region: PRK10829 1249634007628 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1249634007629 catalytic site [active] 1249634007630 putative active site [active] 1249634007631 putative substrate binding site [chemical binding]; other site 1249634007632 HRDC domain; Region: HRDC; pfam00570 1249634007633 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 1249634007634 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1249634007635 acyl-activating enzyme (AAE) consensus motif; other site 1249634007636 putative AMP binding site [chemical binding]; other site 1249634007637 putative active site [active] 1249634007638 putative CoA binding site [chemical binding]; other site 1249634007639 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 1249634007640 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1249634007641 Glycoprotease family; Region: Peptidase_M22; pfam00814 1249634007642 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1249634007643 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1249634007644 ATP binding site [chemical binding]; other site 1249634007645 DEAD_2; Region: DEAD_2; pfam06733 1249634007646 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1249634007647 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 1249634007648 homotrimer interaction site [polypeptide binding]; other site 1249634007649 putative active site [active] 1249634007650 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 1249634007651 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 1249634007652 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1249634007653 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1249634007654 active site 1249634007655 intersubunit interface [polypeptide binding]; other site 1249634007656 catalytic residue [active] 1249634007657 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1249634007658 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1249634007659 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1249634007660 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1249634007661 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1249634007662 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1249634007663 putative active site [active] 1249634007664 pyruvate kinase; Provisional; Region: PRK05826 1249634007665 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1249634007666 domain interfaces; other site 1249634007667 active site 1249634007668 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1249634007669 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1249634007670 putative acyl-acceptor binding pocket; other site 1249634007671 putative peptidase; Provisional; Region: PRK11649 1249634007672 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 1249634007673 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1249634007674 Peptidase family M23; Region: Peptidase_M23; pfam01551 1249634007675 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 1249634007676 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1249634007677 metal binding site [ion binding]; metal-binding site 1249634007678 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 1249634007679 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1249634007680 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1249634007681 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1249634007682 ABC-ATPase subunit interface; other site 1249634007683 dimer interface [polypeptide binding]; other site 1249634007684 putative PBP binding regions; other site 1249634007685 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1249634007686 Helix-turn-helix domain; Region: HTH_28; pfam13518 1249634007687 putative transposase OrfB; Reviewed; Region: PHA02517 1249634007688 Integrase core domain; Region: rve; pfam00665 1249634007689 Integrase core domain; Region: rve_3; pfam13683 1249634007690 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1249634007691 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1249634007692 Walker A motif; other site 1249634007693 ATP binding site [chemical binding]; other site 1249634007694 Walker B motif; other site 1249634007695 arginine finger; other site 1249634007696 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1249634007697 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1249634007698 RuvA N terminal domain; Region: RuvA_N; pfam01330 1249634007699 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1249634007700 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1249634007701 active site 1249634007702 putative DNA-binding cleft [nucleotide binding]; other site 1249634007703 dimer interface [polypeptide binding]; other site 1249634007704 hypothetical protein; Validated; Region: PRK00110 1249634007705 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 1249634007706 nudix motif; other site 1249634007707 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1249634007708 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1249634007709 dimer interface [polypeptide binding]; other site 1249634007710 anticodon binding site; other site 1249634007711 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1249634007712 homodimer interface [polypeptide binding]; other site 1249634007713 motif 1; other site 1249634007714 active site 1249634007715 motif 2; other site 1249634007716 GAD domain; Region: GAD; pfam02938 1249634007717 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1249634007718 active site 1249634007719 motif 3; other site 1249634007720 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 1249634007721 Isochorismatase family; Region: Isochorismatase; pfam00857 1249634007722 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1249634007723 catalytic triad [active] 1249634007724 conserved cis-peptide bond; other site 1249634007725 hypothetical protein; Provisional; Region: PRK10302 1249634007726 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 1249634007727 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1249634007728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1249634007729 S-adenosylmethionine binding site [chemical binding]; other site 1249634007730 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1249634007731 S-adenosylmethionine binding site [chemical binding]; other site 1249634007732 HPP family; Region: HPP; pfam04982 1249634007733 copper homeostasis protein CutC; Provisional; Region: PRK11572 1249634007734 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 1249634007735 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1249634007736 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634007737 homodimer interface [polypeptide binding]; other site 1249634007738 catalytic residue [active] 1249634007739 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 1249634007740 putative metal binding site [ion binding]; other site 1249634007741 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1249634007742 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1249634007743 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1249634007744 active site 1249634007745 HIGH motif; other site 1249634007746 KMSK motif region; other site 1249634007747 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1249634007748 tRNA binding surface [nucleotide binding]; other site 1249634007749 anticodon binding site; other site 1249634007750 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1249634007751 MviN-like protein; Region: MVIN; pfam03023 1249634007752 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1249634007753 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1249634007754 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 1249634007755 hypothetical protein; Provisional; Region: PRK11239 1249634007756 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 1249634007757 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1249634007758 glutaredoxin 2; Provisional; Region: PRK10387 1249634007759 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 1249634007760 C-terminal domain interface [polypeptide binding]; other site 1249634007761 GSH binding site (G-site) [chemical binding]; other site 1249634007762 catalytic residues [active] 1249634007763 putative dimer interface [polypeptide binding]; other site 1249634007764 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 1249634007765 N-terminal domain interface [polypeptide binding]; other site 1249634007766 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1249634007767 ABC1 family; Region: ABC1; pfam03109 1249634007768 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1249634007769 active site 1249634007770 ATP binding site [chemical binding]; other site 1249634007771 lipoprotein; Provisional; Region: PRK10598 1249634007772 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 1249634007773 putative hydrolase; Validated; Region: PRK09248 1249634007774 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 1249634007775 active site 1249634007776 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 1249634007777 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1249634007778 putative ligand binding site [chemical binding]; other site 1249634007779 NAD binding site [chemical binding]; other site 1249634007780 dimerization interface [polypeptide binding]; other site 1249634007781 catalytic site [active] 1249634007782 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 1249634007783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634007784 POT family; Region: PTR2; cl17359 1249634007785 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1249634007786 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1249634007787 hypothetical protein; Provisional; Region: PRK10941 1249634007788 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1249634007789 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1249634007790 binding surface 1249634007791 TPR motif; other site 1249634007792 Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247 1249634007793 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1249634007794 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1249634007795 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1249634007796 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1249634007797 RF-1 domain; Region: RF-1; pfam00472 1249634007798 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1249634007799 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1249634007800 tRNA; other site 1249634007801 putative tRNA binding site [nucleotide binding]; other site 1249634007802 putative NADP binding site [chemical binding]; other site 1249634007803 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1249634007804 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1249634007805 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1249634007806 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 1249634007807 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1249634007808 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1249634007809 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1249634007810 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1249634007811 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1249634007812 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1249634007813 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1249634007814 active site 1249634007815 hypothetical protein; Provisional; Region: PRK10692 1249634007816 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1249634007817 putative active site [active] 1249634007818 catalytic residue [active] 1249634007819 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1249634007820 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1249634007821 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1249634007822 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1249634007823 GTP-binding protein YchF; Reviewed; Region: PRK09601 1249634007824 YchF GTPase; Region: YchF; cd01900 1249634007825 G1 box; other site 1249634007826 GTP/Mg2+ binding site [chemical binding]; other site 1249634007827 Switch I region; other site 1249634007828 G2 box; other site 1249634007829 Switch II region; other site 1249634007830 G3 box; other site 1249634007831 G4 box; other site 1249634007832 G5 box; other site 1249634007833 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1249634007834 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 1249634007835 Cytochrome c; Region: Cytochrom_C; pfam00034 1249634007836 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1249634007837 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1249634007838 Cytochrome c; Region: Cytochrom_C; pfam00034 1249634007839 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1249634007840 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1249634007841 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1249634007842 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1249634007843 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1249634007844 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1249634007845 catalytic loop [active] 1249634007846 iron binding site [ion binding]; other site 1249634007847 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1249634007848 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1249634007849 CGNR zinc finger; Region: zf-CGNR; pfam11706 1249634007850 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1249634007851 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1249634007852 Melibiase; Region: Melibiase; pfam02065 1249634007853 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1249634007854 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1249634007855 intersubunit interface [polypeptide binding]; other site 1249634007856 active site 1249634007857 zinc binding site [ion binding]; other site 1249634007858 Na+ binding site [ion binding]; other site 1249634007859 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 1249634007860 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1249634007861 dimer interface [polypeptide binding]; other site 1249634007862 active site 1249634007863 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 1249634007864 putative active site [active] 1249634007865 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1249634007866 active pocket/dimerization site; other site 1249634007867 active site 1249634007868 phosphorylation site [posttranslational modification] 1249634007869 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1249634007870 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 1249634007871 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1249634007872 active site 1249634007873 phosphorylation site [posttranslational modification] 1249634007874 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 1249634007875 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 1249634007876 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1249634007877 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1249634007878 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1249634007879 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1249634007880 Class I aldolases; Region: Aldolase_Class_I; cl17187 1249634007881 catalytic residue [active] 1249634007882 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1249634007883 Cache domain; Region: Cache_2; cl07034 1249634007884 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1249634007885 ATP binding site [chemical binding]; other site 1249634007886 Mg2+ binding site [ion binding]; other site 1249634007887 G-X-G motif; other site 1249634007888 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 1249634007889 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634007890 active site 1249634007891 phosphorylation site [posttranslational modification] 1249634007892 intermolecular recognition site; other site 1249634007893 dimerization interface [polypeptide binding]; other site 1249634007894 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1249634007895 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1249634007896 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1249634007897 non-specific DNA binding site [nucleotide binding]; other site 1249634007898 salt bridge; other site 1249634007899 sequence-specific DNA binding site [nucleotide binding]; other site 1249634007900 Cupin domain; Region: Cupin_2; cl17218 1249634007901 AzlC protein; Region: AzlC; cl00570 1249634007902 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1249634007903 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 1249634007904 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1249634007905 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1249634007906 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1249634007907 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1249634007908 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 1249634007909 Domain of unknown function (DUF1864); Region: DUF1864; pfam08933 1249634007910 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1249634007911 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1249634007912 This alignment model represents the N-terminal rieske domain of the oxygenase alpha subunit of aminopyrrolnitrin oxygenase (PrnD). PrnD is a novel Rieske N-oxygenase that catalyzes the final step in the pyrrolnitrin biosynthetic pathway, the oxidation...; Region: Rieske_RO_Alpha_PrnD; cd03537 1249634007913 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1249634007914 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 1249634007915 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1249634007916 CopC domain; Region: CopC; cl01012 1249634007917 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1249634007918 Ferritin-like domain; Region: Ferritin; pfam00210 1249634007919 ferroxidase diiron center [ion binding]; other site 1249634007920 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 1249634007921 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1249634007922 exodeoxyribonuclease X; Provisional; Region: PRK07983 1249634007923 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1249634007924 active site 1249634007925 catalytic site [active] 1249634007926 substrate binding site [chemical binding]; other site 1249634007927 protease 2; Provisional; Region: PRK10115 1249634007928 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1249634007929 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 1249634007930 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1249634007931 putative metal binding site [ion binding]; other site 1249634007932 YebF-like protein; Region: YebF; cl10126 1249634007933 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 1249634007934 YebG protein; Region: YebG; pfam07130 1249634007935 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1249634007936 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1249634007937 ATP binding site [chemical binding]; other site 1249634007938 Mg++ binding site [ion binding]; other site 1249634007939 motif III; other site 1249634007940 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1249634007941 nucleotide binding region [chemical binding]; other site 1249634007942 ATP-binding site [chemical binding]; other site 1249634007943 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 1249634007944 putative RNA binding site [nucleotide binding]; other site 1249634007945 contains cspA thermoregulator; D781_2619; IMG reference gene:2517284009 1249634007946 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1249634007947 DNA-binding site [nucleotide binding]; DNA binding site 1249634007948 RNA-binding motif; other site 1249634007949 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 1249634007950 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1249634007951 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1249634007952 ATP-grasp domain; Region: ATP-grasp; pfam02222 1249634007953 hypothetical protein; Provisional; Region: PRK05114 1249634007954 putative glycosyl transferase; Provisional; Region: PRK10073 1249634007955 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1249634007956 active site 1249634007957 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 1249634007958 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1249634007959 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1249634007960 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1249634007961 putative active site [active] 1249634007962 putative CoA binding site [chemical binding]; other site 1249634007963 nudix motif; other site 1249634007964 metal binding site [ion binding]; metal-binding site 1249634007965 L-serine deaminase; Provisional; Region: PRK15023 1249634007966 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1249634007967 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1249634007968 phage resistance protein; Provisional; Region: PRK10551 1249634007969 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1249634007970 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1249634007971 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1249634007972 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1249634007973 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1249634007974 Transporter associated domain; Region: CorC_HlyC; smart01091 1249634007975 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1249634007976 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1249634007977 active pocket/dimerization site; other site 1249634007978 active site 1249634007979 phosphorylation site [posttranslational modification] 1249634007980 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1249634007981 active site 1249634007982 phosphorylation site [posttranslational modification] 1249634007983 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1249634007984 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 1249634007985 hypothetical protein; Provisional; Region: PRK02913 1249634007986 Domain of unknown function DUF; Region: DUF204; pfam02659 1249634007987 Domain of unknown function DUF; Region: DUF204; pfam02659 1249634007988 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1249634007989 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1249634007990 S-adenosylmethionine binding site [chemical binding]; other site 1249634007991 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1249634007992 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1249634007993 contains cspA thermoregulator; D781_2638; IMG reference gene:2517284028 1249634007994 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1249634007995 DNA-binding site [nucleotide binding]; DNA binding site 1249634007996 RNA-binding motif; other site 1249634007997 Protein of unknown function (DUF796); Region: DUF796; pfam05638 1249634007998 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1249634007999 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1249634008000 aromatic amino acid transporter; Provisional; Region: PRK10238 1249634008001 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 1249634008002 Protein of unknown function (DUF2591); Region: DUF2591; pfam10765 1249634008003 YebO-like protein; Region: YebO; pfam13974 1249634008004 MgrB protein; Region: MgrB; pfam13998 1249634008005 YobH-like protein; Region: YobH; pfam13996 1249634008006 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 1249634008007 YccJ-like protein; Region: YccJ; cl08091 1249634008008 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1249634008009 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634008010 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1249634008011 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1249634008012 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 1249634008013 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1249634008014 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1249634008015 trimer interface [polypeptide binding]; other site 1249634008016 eyelet of channel; other site 1249634008017 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 1249634008018 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1249634008019 putative active site [active] 1249634008020 Zn binding site [ion binding]; other site 1249634008021 succinylarginine dihydrolase; Provisional; Region: PRK13281 1249634008022 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 1249634008023 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 1249634008024 NAD(P) binding site [chemical binding]; other site 1249634008025 catalytic residues [active] 1249634008026 arginine succinyltransferase; Provisional; Region: PRK10456 1249634008027 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1249634008028 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 1249634008029 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1249634008030 inhibitor-cofactor binding pocket; inhibition site 1249634008031 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634008032 catalytic residue [active] 1249634008033 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1249634008034 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1249634008035 DNA-binding site [nucleotide binding]; DNA binding site 1249634008036 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1249634008037 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634008038 homodimer interface [polypeptide binding]; other site 1249634008039 catalytic residue [active] 1249634008040 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1249634008041 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1249634008042 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1249634008043 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1249634008044 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 1249634008045 excinuclease ABC, A subunit; Region: uvra; TIGR00630 1249634008046 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1249634008047 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1249634008048 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1249634008049 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1249634008050 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1249634008051 [4Fe-4S] binding site [ion binding]; other site 1249634008052 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1249634008053 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1249634008054 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1249634008055 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1249634008056 molybdopterin cofactor binding site; other site 1249634008057 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1249634008058 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1249634008059 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1249634008060 active site 1249634008061 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 1249634008062 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1249634008063 putative ADP-binding pocket [chemical binding]; other site 1249634008064 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1249634008065 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1249634008066 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1249634008067 active site 1249634008068 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 1249634008069 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1249634008070 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1249634008071 tyrosine kinase; Provisional; Region: PRK11519 1249634008072 Chain length determinant protein; Region: Wzz; pfam02706 1249634008073 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1249634008074 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1249634008075 polysaccharide export protein Wza; Provisional; Region: PRK15078 1249634008076 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1249634008077 SLBB domain; Region: SLBB; pfam10531 1249634008078 SLBB domain; Region: SLBB; pfam10531 1249634008079 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 1249634008080 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1249634008081 Mg++ binding site [ion binding]; other site 1249634008082 putative catalytic motif [active] 1249634008083 substrate binding site [chemical binding]; other site 1249634008084 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1249634008085 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1249634008086 NAD(P) binding site [chemical binding]; other site 1249634008087 active site 1249634008088 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1249634008089 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1249634008090 DNA binding site [nucleotide binding] 1249634008091 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1249634008092 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 1249634008093 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1249634008094 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1249634008095 dimerization interface [polypeptide binding]; other site 1249634008096 Histidine kinase; Region: HisKA_3; pfam07730 1249634008097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1249634008098 ATP binding site [chemical binding]; other site 1249634008099 Mg2+ binding site [ion binding]; other site 1249634008100 G-X-G motif; other site 1249634008101 transcriptional regulator NarL; Provisional; Region: PRK10651 1249634008102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634008103 active site 1249634008104 phosphorylation site [posttranslational modification] 1249634008105 intermolecular recognition site; other site 1249634008106 dimerization interface [polypeptide binding]; other site 1249634008107 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1249634008108 DNA binding residues [nucleotide binding] 1249634008109 dimerization interface [polypeptide binding]; other site 1249634008110 putative invasin; Provisional; Region: PRK10177 1249634008111 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1249634008112 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1249634008113 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1249634008114 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1249634008115 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1249634008116 [4Fe-4S] binding site [ion binding]; other site 1249634008117 molybdopterin cofactor binding site; other site 1249634008118 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1249634008119 molybdopterin cofactor binding site; other site 1249634008120 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1249634008121 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1249634008122 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1249634008123 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1249634008124 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1249634008125 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1249634008126 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1249634008127 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1249634008128 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1249634008129 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1249634008130 Walker A/P-loop; other site 1249634008131 ATP binding site [chemical binding]; other site 1249634008132 Q-loop/lid; other site 1249634008133 ABC transporter signature motif; other site 1249634008134 Walker B; other site 1249634008135 D-loop; other site 1249634008136 H-loop/switch region; other site 1249634008137 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1249634008138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634008139 dimer interface [polypeptide binding]; other site 1249634008140 conserved gate region; other site 1249634008141 putative PBP binding loops; other site 1249634008142 ABC-ATPase subunit interface; other site 1249634008143 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1249634008144 NMT1-like family; Region: NMT1_2; pfam13379 1249634008145 Nitrate and nitrite sensing; Region: NIT; pfam08376 1249634008146 ANTAR domain; Region: ANTAR; pfam03861 1249634008147 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1249634008148 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1249634008149 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1249634008150 Na binding site [ion binding]; other site 1249634008151 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 1249634008152 Predicted transcriptional regulator [Transcription]; Region: COG3905 1249634008153 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1249634008154 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1249634008155 Glutamate binding site [chemical binding]; other site 1249634008156 NAD binding site [chemical binding]; other site 1249634008157 catalytic residues [active] 1249634008158 Oxoglutarate and iron-dependent oxygenase degradation C-term; Region: Ofd1_CTDD; pfam10637 1249634008159 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1249634008160 Predicted ATPase [General function prediction only]; Region: COG1485 1249634008161 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 1249634008162 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1249634008163 Walker A/P-loop; other site 1249634008164 ATP binding site [chemical binding]; other site 1249634008165 Q-loop/lid; other site 1249634008166 ABC transporter signature motif; other site 1249634008167 Walker B; other site 1249634008168 D-loop; other site 1249634008169 H-loop/switch region; other site 1249634008170 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1249634008171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634008172 dimer interface [polypeptide binding]; other site 1249634008173 conserved gate region; other site 1249634008174 putative PBP binding loops; other site 1249634008175 ABC-ATPase subunit interface; other site 1249634008176 cystine transporter subunit; Provisional; Region: PRK11260 1249634008177 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1249634008178 substrate binding pocket [chemical binding]; other site 1249634008179 membrane-bound complex binding site; other site 1249634008180 hinge residues; other site 1249634008181 D-cysteine desulfhydrase; Validated; Region: PRK03910 1249634008182 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 1249634008183 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634008184 catalytic residue [active] 1249634008185 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 1249634008186 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 1249634008187 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1249634008188 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1249634008189 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1249634008190 DNA binding residues [nucleotide binding] 1249634008191 flagellin; Validated; Region: PRK06819 1249634008192 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1249634008193 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1249634008194 flagellar capping protein; Reviewed; Region: fliD; PRK08032 1249634008195 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1249634008196 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1249634008197 flagellar protein FliS; Validated; Region: fliS; PRK05685 1249634008198 Flagellar protein FliT; Region: FliT; cl05125 1249634008199 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1249634008200 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634008201 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 1249634008202 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1249634008203 Sulfatase; Region: Sulfatase; pfam00884 1249634008204 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1249634008205 CoenzymeA binding site [chemical binding]; other site 1249634008206 subunit interaction site [polypeptide binding]; other site 1249634008207 PHB binding site; other site 1249634008208 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 1249634008209 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1249634008210 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1249634008211 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1249634008212 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1249634008213 FliG C-terminal domain; Region: FliG_C; pfam01706 1249634008214 flagellar assembly protein H; Validated; Region: fliH; PRK05687 1249634008215 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 1249634008216 Flagellar assembly protein FliH; Region: FliH; pfam02108 1249634008217 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 1249634008218 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1249634008219 Walker A motif/ATP binding site; other site 1249634008220 Walker B motif; other site 1249634008221 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 1249634008222 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1249634008223 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 1249634008224 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 1249634008225 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1249634008226 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1249634008227 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 1249634008228 flagellar motor switch protein; Validated; Region: fliN; PRK05698 1249634008229 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 1249634008230 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1249634008231 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1249634008232 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1249634008233 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 1249634008234 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1249634008235 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 1249634008236 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1249634008237 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1249634008238 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 1249634008239 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 1249634008240 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1249634008241 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1249634008242 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1249634008243 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 1249634008244 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 1249634008245 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1249634008246 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1249634008247 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1249634008248 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 1249634008249 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1249634008250 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1249634008251 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1249634008252 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1249634008253 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1249634008254 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1249634008255 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 1249634008256 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1249634008257 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1249634008258 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1249634008259 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1249634008260 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1249634008261 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1249634008262 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1249634008263 SAF-like; Region: SAF_2; pfam13144 1249634008264 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1249634008265 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 1249634008266 FlgN protein; Region: FlgN; cl09176 1249634008267 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 1249634008268 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1249634008269 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1249634008270 DNA binding residues [nucleotide binding] 1249634008271 dimerization interface [polypeptide binding]; other site 1249634008272 chaperone protein HchA; Provisional; Region: PRK04155 1249634008273 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1249634008274 conserved cys residue [active] 1249634008275 Flagellar protein FlhE; Region: FlhE; pfam06366 1249634008276 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1249634008277 FHIPEP family; Region: FHIPEP; pfam00771 1249634008278 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK12468 1249634008279 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1249634008280 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1249634008281 oligomeric interface; other site 1249634008282 putative active site [active] 1249634008283 homodimer interface [polypeptide binding]; other site 1249634008284 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 1249634008285 chemotaxis regulator CheZ; Provisional; Region: PRK11166 1249634008286 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1249634008287 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634008288 active site 1249634008289 phosphorylation site [posttranslational modification] 1249634008290 intermolecular recognition site; other site 1249634008291 dimerization interface [polypeptide binding]; other site 1249634008292 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1249634008293 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634008294 active site 1249634008295 phosphorylation site [posttranslational modification] 1249634008296 intermolecular recognition site; other site 1249634008297 dimerization interface [polypeptide binding]; other site 1249634008298 CheB methylesterase; Region: CheB_methylest; pfam01339 1249634008299 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 1249634008300 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1249634008301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1249634008302 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1249634008303 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1249634008304 dimer interface [polypeptide binding]; other site 1249634008305 ligand binding site [chemical binding]; other site 1249634008306 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1249634008307 dimerization interface [polypeptide binding]; other site 1249634008308 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1249634008309 dimer interface [polypeptide binding]; other site 1249634008310 putative CheW interface [polypeptide binding]; other site 1249634008311 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1249634008312 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1249634008313 dimer interface [polypeptide binding]; other site 1249634008314 ligand binding site [chemical binding]; other site 1249634008315 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1249634008316 dimerization interface [polypeptide binding]; other site 1249634008317 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1249634008318 dimer interface [polypeptide binding]; other site 1249634008319 putative CheW interface [polypeptide binding]; other site 1249634008320 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1249634008321 putative CheA interaction surface; other site 1249634008322 chemotaxis protein CheA; Provisional; Region: PRK10547 1249634008323 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1249634008324 putative binding surface; other site 1249634008325 active site 1249634008326 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1249634008327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1249634008328 ATP binding site [chemical binding]; other site 1249634008329 Mg2+ binding site [ion binding]; other site 1249634008330 G-X-G motif; other site 1249634008331 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1249634008332 flagellar motor protein MotB; Validated; Region: motB; PRK09041 1249634008333 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1249634008334 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1249634008335 ligand binding site [chemical binding]; other site 1249634008336 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1249634008337 flagellar motor protein MotA; Validated; Region: PRK09110 1249634008338 transcriptional activator FlhC; Provisional; Region: PRK12722 1249634008339 transcriptional activator FlhD; Provisional; Region: PRK02909 1249634008340 Haemolysin expression modulating protein; Region: HHA; cl11501 1249634008341 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1249634008342 Ligand Binding Site [chemical binding]; other site 1249634008343 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1249634008344 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1249634008345 NAD(P) binding site [chemical binding]; other site 1249634008346 substrate binding site [chemical binding]; other site 1249634008347 dimer interface [polypeptide binding]; other site 1249634008348 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 1249634008349 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 1249634008350 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1249634008351 hypothetical protein; Provisional; Region: PRK07033 1249634008352 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 1249634008353 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1249634008354 ligand binding site [chemical binding]; other site 1249634008355 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 1249634008356 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1249634008357 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1249634008358 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 1249634008359 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 1249634008360 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1249634008361 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 1249634008362 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 1249634008363 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1249634008364 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 1249634008365 Protein of unknown function (DUF796); Region: DUF796; pfam05638 1249634008366 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 1249634008367 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1249634008368 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 1249634008369 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1249634008370 phosphopeptide binding site; other site 1249634008371 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 1249634008372 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1249634008373 active site 1249634008374 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 1249634008375 ImpE protein; Region: ImpE; pfam07024 1249634008376 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1249634008377 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1249634008378 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1249634008379 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 1249634008380 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1249634008381 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1249634008382 Walker A motif; other site 1249634008383 ATP binding site [chemical binding]; other site 1249634008384 Walker B motif; other site 1249634008385 arginine finger; other site 1249634008386 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1249634008387 Walker A motif; other site 1249634008388 ATP binding site [chemical binding]; other site 1249634008389 Walker B motif; other site 1249634008390 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1249634008391 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1249634008392 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1249634008393 active site 1249634008394 ATP binding site [chemical binding]; other site 1249634008395 substrate binding site [chemical binding]; other site 1249634008396 activation loop (A-loop); other site 1249634008397 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1249634008398 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1249634008399 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1249634008400 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1249634008401 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1249634008402 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1249634008403 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 1249634008404 Uncharacterized protein family (UPF0231); Region: UPF0231; cl11474 1249634008405 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 1249634008406 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 1249634008407 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634008408 putative substrate translocation pore; other site 1249634008409 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634008410 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634008411 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634008412 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1249634008413 putative effector binding pocket; other site 1249634008414 dimerization interface [polypeptide binding]; other site 1249634008415 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1249634008416 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1249634008417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3792 1249634008418 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1249634008419 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 1249634008420 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1249634008421 MoaE homodimer interface [polypeptide binding]; other site 1249634008422 MoaD interaction [polypeptide binding]; other site 1249634008423 active site residues [active] 1249634008424 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1249634008425 MoaE interaction surface [polypeptide binding]; other site 1249634008426 MoeB interaction surface [polypeptide binding]; other site 1249634008427 thiocarboxylated glycine; other site 1249634008428 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1249634008429 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1249634008430 FeS/SAM binding site; other site 1249634008431 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1249634008432 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1249634008433 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1249634008434 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1249634008435 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1249634008436 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1249634008437 putative molybdopterin cofactor binding site [chemical binding]; other site 1249634008438 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1249634008439 putative molybdopterin cofactor binding site; other site 1249634008440 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1249634008441 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1249634008442 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1249634008443 putative molybdopterin cofactor binding site [chemical binding]; other site 1249634008444 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1249634008445 putative molybdopterin cofactor binding site; other site 1249634008446 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1249634008447 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1249634008448 Bacterial transcriptional regulator; Region: IclR; pfam01614 1249634008449 Coenzyme A transferase; Region: CoA_trans; cl17247 1249634008450 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1249634008451 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1249634008452 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1249634008453 dimer interface [polypeptide binding]; other site 1249634008454 active site 1249634008455 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1249634008456 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 1249634008457 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 1249634008458 octamer interface [polypeptide binding]; other site 1249634008459 active site 1249634008460 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 1249634008461 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 1249634008462 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1249634008463 active site 1249634008464 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 1249634008465 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1249634008466 iron-sulfur cluster [ion binding]; other site 1249634008467 [2Fe-2S] cluster binding site [ion binding]; other site 1249634008468 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1249634008469 putative alpha subunit interface [polypeptide binding]; other site 1249634008470 putative active site [active] 1249634008471 putative substrate binding site [chemical binding]; other site 1249634008472 Fe binding site [ion binding]; other site 1249634008473 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1249634008474 inter-subunit interface; other site 1249634008475 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 1249634008476 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1249634008477 catalytic loop [active] 1249634008478 iron binding site [ion binding]; other site 1249634008479 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 1249634008480 FAD binding pocket [chemical binding]; other site 1249634008481 FAD binding motif [chemical binding]; other site 1249634008482 phosphate binding motif [ion binding]; other site 1249634008483 beta-alpha-beta structure motif; other site 1249634008484 NAD binding pocket [chemical binding]; other site 1249634008485 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 1249634008486 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 1249634008487 putative NAD(P) binding site [chemical binding]; other site 1249634008488 active site 1249634008489 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1249634008490 ArsC family; Region: ArsC; pfam03960 1249634008491 catalytic residues [active] 1249634008492 arsenical pump membrane protein; Provisional; Region: PRK15445 1249634008493 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1249634008494 transmembrane helices; other site 1249634008495 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1249634008496 dimerization interface [polypeptide binding]; other site 1249634008497 putative DNA binding site [nucleotide binding]; other site 1249634008498 putative Zn2+ binding site [ion binding]; other site 1249634008499 magnesium-transporting ATPase; Provisional; Region: PRK15122 1249634008500 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1249634008501 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1249634008502 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1249634008503 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1249634008504 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1249634008505 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1249634008506 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1249634008507 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634008508 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1249634008509 dimerization interface [polypeptide binding]; other site 1249634008510 substrate binding pocket [chemical binding]; other site 1249634008511 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1249634008512 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1249634008513 catalytic residue [active] 1249634008514 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1249634008515 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1249634008516 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 1249634008517 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1249634008518 DNA binding residues [nucleotide binding] 1249634008519 dimerization interface [polypeptide binding]; other site 1249634008520 hypothetical protein; Provisional; Region: PRK10708 1249634008521 contains cspA thermoregulator; D781_2865; IMG reference gene:2517284255 1249634008522 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1249634008523 DNA-binding site [nucleotide binding]; DNA binding site 1249634008524 RNA-binding motif; other site 1249634008525 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1249634008526 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1249634008527 NAD(P) binding site [chemical binding]; other site 1249634008528 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1249634008529 putative catalytic site [active] 1249634008530 putative metal binding site [ion binding]; other site 1249634008531 putative phosphate binding site [ion binding]; other site 1249634008532 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 1249634008533 hypothetical protein; Provisional; Region: PRK10457 1249634008534 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1249634008535 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1249634008536 putative acyl-acceptor binding pocket; other site 1249634008537 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634008538 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634008539 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1249634008540 putative effector binding pocket; other site 1249634008541 putative dimerization interface [polypeptide binding]; other site 1249634008542 short chain dehydrogenase; Provisional; Region: PRK12744 1249634008543 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1249634008544 NADP binding site [chemical binding]; other site 1249634008545 homodimer interface [polypeptide binding]; other site 1249634008546 active site 1249634008547 substrate binding site [chemical binding]; other site 1249634008548 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1249634008549 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1249634008550 dimer interface [polypeptide binding]; other site 1249634008551 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1249634008552 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1249634008553 metal binding site [ion binding]; metal-binding site 1249634008554 active site 1249634008555 I-site; other site 1249634008556 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 1249634008557 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 1249634008558 substrate binding site [chemical binding]; other site 1249634008559 dimer interface [polypeptide binding]; other site 1249634008560 NADP binding site [chemical binding]; other site 1249634008561 catalytic residues [active] 1249634008562 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 1249634008563 substrate binding site [chemical binding]; other site 1249634008564 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 1249634008565 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 1249634008566 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 1249634008567 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 1249634008568 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1249634008569 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 1249634008570 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1249634008571 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1249634008572 FAD binding pocket [chemical binding]; other site 1249634008573 FAD binding motif [chemical binding]; other site 1249634008574 phosphate binding motif [ion binding]; other site 1249634008575 beta-alpha-beta structure motif; other site 1249634008576 NAD(p) ribose binding residues [chemical binding]; other site 1249634008577 NAD binding pocket [chemical binding]; other site 1249634008578 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1249634008579 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1249634008580 catalytic loop [active] 1249634008581 iron binding site [ion binding]; other site 1249634008582 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 1249634008583 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1249634008584 substrate binding site [chemical binding]; other site 1249634008585 oxyanion hole (OAH) forming residues; other site 1249634008586 trimer interface [polypeptide binding]; other site 1249634008587 enoyl-CoA hydratase; Provisional; Region: PRK08140 1249634008588 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1249634008589 substrate binding site [chemical binding]; other site 1249634008590 oxyanion hole (OAH) forming residues; other site 1249634008591 trimer interface [polypeptide binding]; other site 1249634008592 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 1249634008593 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1249634008594 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1249634008595 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1249634008596 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1249634008597 CoenzymeA binding site [chemical binding]; other site 1249634008598 subunit interaction site [polypeptide binding]; other site 1249634008599 PHB binding site; other site 1249634008600 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1249634008601 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1249634008602 dimer interface [polypeptide binding]; other site 1249634008603 active site 1249634008604 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 1249634008605 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 1249634008606 active site 1249634008607 AMP binding site [chemical binding]; other site 1249634008608 homodimer interface [polypeptide binding]; other site 1249634008609 acyl-activating enzyme (AAE) consensus motif; other site 1249634008610 CoA binding site [chemical binding]; other site 1249634008611 PaaX-like protein; Region: PaaX; pfam07848 1249634008612 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 1249634008613 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1249634008614 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 1249634008615 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 1249634008616 putative trimer interface [polypeptide binding]; other site 1249634008617 putative metal binding site [ion binding]; other site 1249634008618 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1249634008619 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1249634008620 homotrimer interaction site [polypeptide binding]; other site 1249634008621 putative active site [active] 1249634008622 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1249634008623 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 1249634008624 Predicted flavoprotein [General function prediction only]; Region: COG0431 1249634008625 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1249634008626 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1249634008627 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 1249634008628 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634008629 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1249634008630 putative dimerization interface [polypeptide binding]; other site 1249634008631 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1249634008632 beta-galactosidase; Region: BGL; TIGR03356 1249634008633 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1249634008634 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1249634008635 active site turn [active] 1249634008636 phosphorylation site [posttranslational modification] 1249634008637 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1249634008638 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1249634008639 HPr interaction site; other site 1249634008640 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1249634008641 active site 1249634008642 phosphorylation site [posttranslational modification] 1249634008643 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1249634008644 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1249634008645 DNA binding site [nucleotide binding] 1249634008646 domain linker motif; other site 1249634008647 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1249634008648 dimerization interface [polypeptide binding]; other site 1249634008649 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1249634008650 methionine cluster; other site 1249634008651 active site 1249634008652 phosphorylation site [posttranslational modification] 1249634008653 metal binding site [ion binding]; metal-binding site 1249634008654 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1249634008655 beta-galactosidase; Region: BGL; TIGR03356 1249634008656 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1249634008657 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1249634008658 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1249634008659 active site 1249634008660 P-loop; other site 1249634008661 phosphorylation site [posttranslational modification] 1249634008662 alanine-tRNA ligase; Region: PLN02961 1249634008663 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 1249634008664 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634008665 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634008666 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1249634008667 putative effector binding pocket; other site 1249634008668 dimerization interface [polypeptide binding]; other site 1249634008669 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 1249634008670 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1249634008671 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1249634008672 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 1249634008673 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1249634008674 catalytic core [active] 1249634008675 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1249634008676 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1249634008677 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1249634008678 transmembrane helices; other site 1249634008679 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 1249634008680 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498 1249634008681 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 1249634008682 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1249634008683 citrate lyase subunit gamma; Provisional; Region: PRK13253 1249634008684 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 1249634008685 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 1249634008686 putative active site [active] 1249634008687 (T/H)XGH motif; other site 1249634008688 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 1249634008689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634008690 active site 1249634008691 phosphorylation site [posttranslational modification] 1249634008692 intermolecular recognition site; other site 1249634008693 dimerization interface [polypeptide binding]; other site 1249634008694 Transcriptional regulator; Region: CitT; pfam12431 1249634008695 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1249634008696 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1249634008697 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1249634008698 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1249634008699 short chain dehydrogenase; Provisional; Region: PRK06500 1249634008700 classical (c) SDRs; Region: SDR_c; cd05233 1249634008701 NAD(P) binding site [chemical binding]; other site 1249634008702 active site 1249634008703 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1249634008704 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1249634008705 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 1249634008706 NADP binding site [chemical binding]; other site 1249634008707 substrate binding site [chemical binding]; other site 1249634008708 active site 1249634008709 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1249634008710 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1249634008711 NAD(P) binding site [chemical binding]; other site 1249634008712 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1249634008713 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1249634008714 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1249634008715 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1249634008716 NAD(P) binding site [chemical binding]; other site 1249634008717 active site 1249634008718 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1249634008719 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634008720 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1249634008721 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634008722 Cupin domain; Region: Cupin_2; cl17218 1249634008723 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1249634008724 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1249634008725 Bacterial transcriptional regulator; Region: IclR; pfam01614 1249634008726 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 1249634008727 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 1249634008728 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1249634008729 active site 1249634008730 intersubunit interface [polypeptide binding]; other site 1249634008731 catalytic residue [active] 1249634008732 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1249634008733 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1249634008734 active site 1249634008735 putative substrate binding pocket [chemical binding]; other site 1249634008736 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1249634008737 homotrimer interaction site [polypeptide binding]; other site 1249634008738 putative active site [active] 1249634008739 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1249634008740 Na binding site [ion binding]; other site 1249634008741 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1249634008742 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 1249634008743 dimer interface [polypeptide binding]; other site 1249634008744 active site 1249634008745 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1249634008746 substrate binding site [chemical binding]; other site 1249634008747 catalytic residue [active] 1249634008748 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1249634008749 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634008750 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1249634008751 dimerization interface [polypeptide binding]; other site 1249634008752 substrate binding pocket [chemical binding]; other site 1249634008753 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1249634008754 MATE family multidrug exporter; Provisional; Region: PRK10189 1249634008755 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 1249634008756 AMP nucleosidase; Provisional; Region: PRK08292 1249634008757 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1249634008758 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1249634008759 benzoate transport; Region: 2A0115; TIGR00895 1249634008760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634008761 putative substrate translocation pore; other site 1249634008762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634008763 putative substrate translocation pore; other site 1249634008764 putative arabinose transporter; Provisional; Region: PRK03545 1249634008765 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634008766 putative substrate translocation pore; other site 1249634008767 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1249634008768 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1249634008769 active site 1249634008770 catalytic tetrad [active] 1249634008771 hypothetical protein; Provisional; Region: PRK05423 1249634008772 Predicted membrane protein [Function unknown]; Region: COG1289 1249634008773 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1249634008774 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1249634008775 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1249634008776 amidase catalytic site [active] 1249634008777 Zn binding residues [ion binding]; other site 1249634008778 substrate binding site [chemical binding]; other site 1249634008779 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1249634008780 Predicted transcriptional regulator [Transcription]; Region: COG2932 1249634008781 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1249634008782 Catalytic site [active] 1249634008783 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1249634008784 NAD(P) binding site [chemical binding]; other site 1249634008785 active site 1249634008786 Predicted membrane protein [Function unknown]; Region: COG4763 1249634008787 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1249634008788 DinI-like family; Region: DinI; pfam06183 1249634008789 exonuclease I; Provisional; Region: sbcB; PRK11779 1249634008790 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1249634008791 active site 1249634008792 catalytic site [active] 1249634008793 substrate binding site [chemical binding]; other site 1249634008794 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1249634008795 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1249634008796 Ligand Binding Site [chemical binding]; other site 1249634008797 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1249634008798 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1249634008799 putative DNA binding site [nucleotide binding]; other site 1249634008800 putative Zn2+ binding site [ion binding]; other site 1249634008801 Bacterial transcriptional regulator; Region: IclR; pfam01614 1249634008802 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1249634008803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634008804 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1249634008805 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1249634008806 HlyD family secretion protein; Region: HlyD_3; pfam13437 1249634008807 amino acid transporter; Region: 2A0306; TIGR00909 1249634008808 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1249634008809 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1249634008810 non-specific DNA binding site [nucleotide binding]; other site 1249634008811 salt bridge; other site 1249634008812 sequence-specific DNA binding site [nucleotide binding]; other site 1249634008813 Cupin domain; Region: Cupin_2; pfam07883 1249634008814 putative outer membrane receptor; Provisional; Region: PRK13513 1249634008815 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1249634008816 N-terminal plug; other site 1249634008817 ligand-binding site [chemical binding]; other site 1249634008818 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 1249634008819 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 1249634008820 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1249634008821 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1249634008822 Walker A/P-loop; other site 1249634008823 ATP binding site [chemical binding]; other site 1249634008824 Q-loop/lid; other site 1249634008825 ABC transporter signature motif; other site 1249634008826 Walker B; other site 1249634008827 D-loop; other site 1249634008828 H-loop/switch region; other site 1249634008829 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1249634008830 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1249634008831 dimer interface [polypeptide binding]; other site 1249634008832 putative PBP binding regions; other site 1249634008833 ABC-ATPase subunit interface; other site 1249634008834 lysine transporter; Provisional; Region: PRK10836 1249634008835 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1249634008836 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634008837 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1249634008838 putative dimerization interface [polypeptide binding]; other site 1249634008839 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1249634008840 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1249634008841 endonuclease IV; Provisional; Region: PRK01060 1249634008842 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1249634008843 AP (apurinic/apyrimidinic) site pocket; other site 1249634008844 DNA interaction; other site 1249634008845 Metal-binding active site; metal-binding site 1249634008846 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 1249634008847 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 1249634008848 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1249634008849 active site 1249634008850 P-loop; other site 1249634008851 phosphorylation site [posttranslational modification] 1249634008852 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 1249634008853 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1249634008854 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1249634008855 putative substrate binding site [chemical binding]; other site 1249634008856 putative ATP binding site [chemical binding]; other site 1249634008857 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 1249634008858 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1249634008859 active site 1249634008860 phosphorylation site [posttranslational modification] 1249634008861 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1249634008862 dimerization domain swap beta strand [polypeptide binding]; other site 1249634008863 regulatory protein interface [polypeptide binding]; other site 1249634008864 active site 1249634008865 regulatory phosphorylation site [posttranslational modification]; other site 1249634008866 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_19; cd04678 1249634008867 nudix motif; other site 1249634008868 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 1249634008869 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 1249634008870 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1249634008871 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1249634008872 molybdopterin cofactor binding site [chemical binding]; other site 1249634008873 substrate binding site [chemical binding]; other site 1249634008874 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1249634008875 molybdopterin cofactor binding site; other site 1249634008876 Flagellin N-methylase; Region: FliB; cl00497 1249634008877 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1249634008878 aromatic amino acid transport protein; Region: araaP; TIGR00837 1249634008879 elongation factor P; Provisional; Region: PRK04542 1249634008880 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1249634008881 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1249634008882 RNA binding site [nucleotide binding]; other site 1249634008883 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1249634008884 RNA binding site [nucleotide binding]; other site 1249634008885 mannonate dehydratase; Provisional; Region: PRK03906 1249634008886 mannonate dehydratase; Region: uxuA; TIGR00695 1249634008887 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1249634008888 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1249634008889 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1249634008890 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1249634008891 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1249634008892 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1249634008893 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1249634008894 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1249634008895 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1249634008896 active site 1249634008897 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 1249634008898 NlpC/P60 family; Region: NLPC_P60; pfam00877 1249634008899 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1249634008900 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1249634008901 phage resistance protein; Provisional; Region: PRK10551 1249634008902 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1249634008903 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1249634008904 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1249634008905 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1249634008906 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1249634008907 hypothetical protein; Provisional; Region: PRK11835 1249634008908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634008909 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1249634008910 putative substrate translocation pore; other site 1249634008911 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 1249634008912 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1249634008913 RNA binding surface [nucleotide binding]; other site 1249634008914 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1249634008915 active site 1249634008916 uracil binding [chemical binding]; other site 1249634008917 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1249634008918 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1249634008919 ATP binding site [chemical binding]; other site 1249634008920 putative Mg++ binding site [ion binding]; other site 1249634008921 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1249634008922 nucleotide binding region [chemical binding]; other site 1249634008923 ATP-binding site [chemical binding]; other site 1249634008924 Double zinc ribbon; Region: DZR; pfam12773 1249634008925 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1249634008926 5S rRNA interface [nucleotide binding]; other site 1249634008927 CTC domain interface [polypeptide binding]; other site 1249634008928 L16 interface [polypeptide binding]; other site 1249634008929 Nucleoid-associated protein [General function prediction only]; Region: COG3081 1249634008930 nucleoid-associated protein NdpA; Validated; Region: PRK00378 1249634008931 hypothetical protein; Provisional; Region: PRK13689 1249634008932 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 1249634008933 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 1249634008934 Sulfatase; Region: Sulfatase; cl17466 1249634008935 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1249634008936 Helix-turn-helix domain; Region: HTH_28; pfam13518 1249634008937 putative transposase OrfB; Reviewed; Region: PHA02517 1249634008938 Integrase core domain; Region: rve; pfam00665 1249634008939 Integrase core domain; Region: rve_3; pfam13683 1249634008940 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1249634008941 DNA-binding interface [nucleotide binding]; DNA binding site 1249634008942 IS2 transposase TnpB; Reviewed; Region: PRK09409 1249634008943 HTH-like domain; Region: HTH_21; pfam13276 1249634008944 Integrase core domain; Region: rve; pfam00665 1249634008945 Integrase core domain; Region: rve_3; pfam13683 1249634008946 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1249634008947 non-specific DNA interactions [nucleotide binding]; other site 1249634008948 DNA binding site [nucleotide binding] 1249634008949 sequence specific DNA binding site [nucleotide binding]; other site 1249634008950 putative cAMP binding site [chemical binding]; other site 1249634008951 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1249634008952 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1249634008953 Predicted ATPase [General function prediction only]; Region: COG3911 1249634008954 AAA domain; Region: AAA_28; pfam13521 1249634008955 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1249634008956 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634008957 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634008958 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1249634008959 dimerization interface [polypeptide binding]; other site 1249634008960 hypothetical protein; Provisional; Region: PRK07079 1249634008961 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 1249634008962 metal binding site [ion binding]; metal-binding site 1249634008963 putative dimer interface [polypeptide binding]; other site 1249634008964 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634008965 metabolite-proton symporter; Region: 2A0106; TIGR00883 1249634008966 putative substrate translocation pore; other site 1249634008967 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1249634008968 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634008969 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 1249634008970 dimerization interface [polypeptide binding]; other site 1249634008971 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1249634008972 active site clefts [active] 1249634008973 zinc binding site [ion binding]; other site 1249634008974 dimer interface [polypeptide binding]; other site 1249634008975 cyanate hydratase; Validated; Region: PRK02866 1249634008976 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 1249634008977 oligomer interface [polypeptide binding]; other site 1249634008978 active site 1249634008979 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1249634008980 nucleoside/Zn binding site; other site 1249634008981 dimer interface [polypeptide binding]; other site 1249634008982 catalytic motif [active] 1249634008983 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1249634008984 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1249634008985 FAD binding pocket [chemical binding]; other site 1249634008986 FAD binding motif [chemical binding]; other site 1249634008987 phosphate binding motif [ion binding]; other site 1249634008988 beta-alpha-beta structure motif; other site 1249634008989 NAD binding pocket [chemical binding]; other site 1249634008990 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1249634008991 catalytic loop [active] 1249634008992 iron binding site [ion binding]; other site 1249634008993 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1249634008994 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1249634008995 [2Fe-2S] cluster binding site [ion binding]; other site 1249634008996 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 1249634008997 putative alpha subunit interface [polypeptide binding]; other site 1249634008998 putative active site [active] 1249634008999 putative substrate binding site [chemical binding]; other site 1249634009000 Fe binding site [ion binding]; other site 1249634009001 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1249634009002 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1249634009003 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1249634009004 Electron transfer flavoprotein domain; Region: ETF; smart00893 1249634009005 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1249634009006 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 1249634009007 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1249634009008 Cysteine-rich domain; Region: CCG; pfam02754 1249634009009 Cysteine-rich domain; Region: CCG; pfam02754 1249634009010 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 1249634009011 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 1249634009012 putative active site [active] 1249634009013 putative FMN binding site [chemical binding]; other site 1249634009014 putative substrate binding site [chemical binding]; other site 1249634009015 putative catalytic residue [active] 1249634009016 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1249634009017 V4R domain; Region: V4R; cl15268 1249634009018 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1249634009019 Membrane dipeptidase (Peptidase family M19); Region: Peptidase_M19; pfam01244 1249634009020 active site 1249634009021 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 1249634009022 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1249634009023 oligomeric interface; other site 1249634009024 putative active site [active] 1249634009025 homodimer interface [polypeptide binding]; other site 1249634009026 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1249634009027 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1249634009028 conserved cys residue [active] 1249634009029 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634009030 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634009031 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1249634009032 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1249634009033 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1249634009034 BCCT family transporter; Region: BCCT; pfam02028 1249634009035 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 1249634009036 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1249634009037 ligand binding site [chemical binding]; other site 1249634009038 flexible hinge region; other site 1249634009039 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 1249634009040 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1249634009041 metal binding triad; other site 1249634009042 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1249634009043 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1249634009044 active site 1249634009045 catalytic site [active] 1249634009046 substrate binding site [chemical binding]; other site 1249634009047 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1249634009048 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1249634009049 conserved cys residue [active] 1249634009050 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634009051 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634009052 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1249634009053 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1249634009054 dimer interface [polypeptide binding]; other site 1249634009055 active site 1249634009056 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1249634009057 folate binding site [chemical binding]; other site 1249634009058 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 1249634009059 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1249634009060 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 1249634009061 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 1249634009062 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1249634009063 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1249634009064 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1249634009065 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1249634009066 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 1249634009067 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1249634009068 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1249634009069 putative active site [active] 1249634009070 putative substrate binding site [chemical binding]; other site 1249634009071 putative cosubstrate binding site; other site 1249634009072 catalytic site [active] 1249634009073 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 1249634009074 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1249634009075 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1249634009076 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 1249634009077 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1249634009078 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 1249634009079 putative metal binding site [ion binding]; other site 1249634009080 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1249634009081 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1249634009082 trimer interface [polypeptide binding]; other site 1249634009083 eyelet of channel; other site 1249634009084 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 1249634009085 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 1249634009086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1249634009087 ATP binding site [chemical binding]; other site 1249634009088 Mg2+ binding site [ion binding]; other site 1249634009089 G-X-G motif; other site 1249634009090 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1249634009091 putative binding surface; other site 1249634009092 active site 1249634009093 transcriptional regulator RcsB; Provisional; Region: PRK10840 1249634009094 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634009095 active site 1249634009096 phosphorylation site [posttranslational modification] 1249634009097 intermolecular recognition site; other site 1249634009098 dimerization interface [polypeptide binding]; other site 1249634009099 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1249634009100 DNA binding residues [nucleotide binding] 1249634009101 dimerization interface [polypeptide binding]; other site 1249634009102 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 1249634009103 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1249634009104 dimer interface [polypeptide binding]; other site 1249634009105 phosphorylation site [posttranslational modification] 1249634009106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1249634009107 ATP binding site [chemical binding]; other site 1249634009108 Mg2+ binding site [ion binding]; other site 1249634009109 G-X-G motif; other site 1249634009110 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 1249634009111 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634009112 active site 1249634009113 phosphorylation site [posttranslational modification] 1249634009114 intermolecular recognition site; other site 1249634009115 dimerization interface [polypeptide binding]; other site 1249634009116 DNA gyrase subunit A; Validated; Region: PRK05560 1249634009117 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1249634009118 CAP-like domain; other site 1249634009119 active site 1249634009120 primary dimer interface [polypeptide binding]; other site 1249634009121 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1249634009122 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1249634009123 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1249634009124 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1249634009125 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1249634009126 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1249634009127 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1249634009128 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1249634009129 S-adenosylmethionine binding site [chemical binding]; other site 1249634009130 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 1249634009131 ATP cone domain; Region: ATP-cone; pfam03477 1249634009132 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1249634009133 active site 1249634009134 dimer interface [polypeptide binding]; other site 1249634009135 catalytic residues [active] 1249634009136 effector binding site; other site 1249634009137 R2 peptide binding site; other site 1249634009138 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1249634009139 dimer interface [polypeptide binding]; other site 1249634009140 putative radical transfer pathway; other site 1249634009141 diiron center [ion binding]; other site 1249634009142 tyrosyl radical; other site 1249634009143 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1249634009144 catalytic loop [active] 1249634009145 iron binding site [ion binding]; other site 1249634009146 Hok/gef family; Region: HOK_GEF; cl11494 1249634009147 hypothetical protein; Provisional; Region: PRK03673 1249634009148 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1249634009149 putative MPT binding site; other site 1249634009150 Competence-damaged protein; Region: CinA; cl00666 1249634009151 tyrosine transporter TyrP; Provisional; Region: PRK15132 1249634009152 aromatic amino acid transport protein; Region: araaP; TIGR00837 1249634009153 YfaZ precursor; Region: YfaZ; pfam07437 1249634009154 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 1249634009155 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1249634009156 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1249634009157 tetramer interface [polypeptide binding]; other site 1249634009158 heme binding pocket [chemical binding]; other site 1249634009159 NADPH binding site [chemical binding]; other site 1249634009160 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 1249634009161 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1249634009162 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1249634009163 acyl-activating enzyme (AAE) consensus motif; other site 1249634009164 putative AMP binding site [chemical binding]; other site 1249634009165 putative active site [active] 1249634009166 putative CoA binding site [chemical binding]; other site 1249634009167 O-succinylbenzoate synthase; Provisional; Region: PRK05105 1249634009168 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1249634009169 active site 1249634009170 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1249634009171 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1249634009172 substrate binding site [chemical binding]; other site 1249634009173 oxyanion hole (OAH) forming residues; other site 1249634009174 trimer interface [polypeptide binding]; other site 1249634009175 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 1249634009176 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 1249634009177 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1249634009178 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1249634009179 dimer interface [polypeptide binding]; other site 1249634009180 tetramer interface [polypeptide binding]; other site 1249634009181 PYR/PP interface [polypeptide binding]; other site 1249634009182 TPP binding site [chemical binding]; other site 1249634009183 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1249634009184 TPP-binding site; other site 1249634009185 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 1249634009186 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1249634009187 hypothetical protein; Provisional; Region: PRK10404 1249634009188 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 1249634009189 Transmembrane secretion effector; Region: MFS_3; pfam05977 1249634009190 Cupin domain; Region: Cupin_2; cl17218 1249634009191 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1249634009192 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1249634009193 PYR/PP interface [polypeptide binding]; other site 1249634009194 dimer interface [polypeptide binding]; other site 1249634009195 TPP binding site [chemical binding]; other site 1249634009196 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1249634009197 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1249634009198 TPP-binding site [chemical binding]; other site 1249634009199 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634009200 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634009201 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1249634009202 dimerization interface [polypeptide binding]; other site 1249634009203 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1249634009204 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1249634009205 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1249634009206 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1249634009207 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1249634009208 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1249634009209 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1249634009210 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1249634009211 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1249634009212 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1249634009213 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1249634009214 4Fe-4S binding domain; Region: Fer4; pfam00037 1249634009215 4Fe-4S binding domain; Region: Fer4; pfam00037 1249634009216 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1249634009217 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 1249634009218 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1249634009219 catalytic loop [active] 1249634009220 iron binding site [ion binding]; other site 1249634009221 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1249634009222 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1249634009223 [4Fe-4S] binding site [ion binding]; other site 1249634009224 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1249634009225 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 1249634009226 SLBB domain; Region: SLBB; pfam10531 1249634009227 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1249634009228 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1249634009229 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1249634009230 putative dimer interface [polypeptide binding]; other site 1249634009231 [2Fe-2S] cluster binding site [ion binding]; other site 1249634009232 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 1249634009233 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1249634009234 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1249634009235 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 1249634009236 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1249634009237 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 1249634009238 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634009239 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 1249634009240 putative dimerization interface [polypeptide binding]; other site 1249634009241 aminotransferase AlaT; Validated; Region: PRK09265 1249634009242 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1249634009243 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634009244 homodimer interface [polypeptide binding]; other site 1249634009245 catalytic residue [active] 1249634009246 5'-nucleotidase; Provisional; Region: PRK03826 1249634009247 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1249634009248 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1249634009249 TrkA-C domain; Region: TrkA_C; pfam02080 1249634009250 TrkA-C domain; Region: TrkA_C; pfam02080 1249634009251 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1249634009252 putative phosphatase; Provisional; Region: PRK11587 1249634009253 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1249634009254 active site 1249634009255 motif I; other site 1249634009256 motif II; other site 1249634009257 hypothetical protein; Validated; Region: PRK05445 1249634009258 hypothetical protein; Provisional; Region: PRK01816 1249634009259 propionate/acetate kinase; Provisional; Region: PRK12379 1249634009260 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1249634009261 phosphate acetyltransferase; Reviewed; Region: PRK05632 1249634009262 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1249634009263 DRTGG domain; Region: DRTGG; pfam07085 1249634009264 phosphate acetyltransferase; Region: pta; TIGR00651 1249634009265 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1249634009266 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1249634009267 PYR/PP interface [polypeptide binding]; other site 1249634009268 dimer interface [polypeptide binding]; other site 1249634009269 TPP binding site [chemical binding]; other site 1249634009270 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1249634009271 transketolase; Reviewed; Region: PRK05899 1249634009272 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1249634009273 TPP-binding site [chemical binding]; other site 1249634009274 dimer interface [polypeptide binding]; other site 1249634009275 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1249634009276 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1249634009277 active site 1249634009278 P-loop; other site 1249634009279 phosphorylation site [posttranslational modification] 1249634009280 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1249634009281 active site 1249634009282 phosphorylation site [posttranslational modification] 1249634009283 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1249634009284 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1249634009285 DNA binding site [nucleotide binding] 1249634009286 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1249634009287 putative dimerization interface [polypeptide binding]; other site 1249634009288 putative ligand binding site [chemical binding]; other site 1249634009289 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 1249634009290 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1249634009291 nudix motif; other site 1249634009292 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1249634009293 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1249634009294 active site 1249634009295 metal binding site [ion binding]; metal-binding site 1249634009296 homotetramer interface [polypeptide binding]; other site 1249634009297 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1249634009298 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1249634009299 C-terminal domain interface [polypeptide binding]; other site 1249634009300 GSH binding site (G-site) [chemical binding]; other site 1249634009301 dimer interface [polypeptide binding]; other site 1249634009302 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1249634009303 N-terminal domain interface [polypeptide binding]; other site 1249634009304 putative dimer interface [polypeptide binding]; other site 1249634009305 active site 1249634009306 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1249634009307 homooctamer interface [polypeptide binding]; other site 1249634009308 active site 1249634009309 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1249634009310 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1249634009311 putative NAD(P) binding site [chemical binding]; other site 1249634009312 putative active site [active] 1249634009313 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 1249634009314 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1249634009315 Walker A/P-loop; other site 1249634009316 ATP binding site [chemical binding]; other site 1249634009317 Q-loop/lid; other site 1249634009318 ABC transporter signature motif; other site 1249634009319 Walker B; other site 1249634009320 D-loop; other site 1249634009321 H-loop/switch region; other site 1249634009322 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1249634009323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634009324 dimer interface [polypeptide binding]; other site 1249634009325 conserved gate region; other site 1249634009326 putative PBP binding loops; other site 1249634009327 ABC-ATPase subunit interface; other site 1249634009328 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1249634009329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634009330 dimer interface [polypeptide binding]; other site 1249634009331 conserved gate region; other site 1249634009332 putative PBP binding loops; other site 1249634009333 ABC-ATPase subunit interface; other site 1249634009334 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 1249634009335 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1249634009336 substrate binding pocket [chemical binding]; other site 1249634009337 membrane-bound complex binding site; other site 1249634009338 hinge residues; other site 1249634009339 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 1249634009340 Flavoprotein; Region: Flavoprotein; pfam02441 1249634009341 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1249634009342 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1249634009343 active site 1249634009344 tetramer interface [polypeptide binding]; other site 1249634009345 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1249634009346 active site 1249634009347 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1249634009348 colicin V production protein; Provisional; Region: PRK10845 1249634009349 Sporulation related domain; Region: SPOR; cl10051 1249634009350 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 1249634009351 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1249634009352 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1249634009353 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1249634009354 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1249634009355 hypothetical protein; Provisional; Region: PRK10847 1249634009356 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1249634009357 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1249634009358 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1249634009359 dimerization interface 3.5A [polypeptide binding]; other site 1249634009360 active site 1249634009361 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 1249634009362 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1249634009363 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 1249634009364 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 1249634009365 ligand binding site [chemical binding]; other site 1249634009366 NAD binding site [chemical binding]; other site 1249634009367 catalytic site [active] 1249634009368 homodimer interface [polypeptide binding]; other site 1249634009369 Cupin domain; Region: Cupin_2; pfam07883 1249634009370 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1249634009371 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634009372 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1249634009373 EamA-like transporter family; Region: EamA; pfam00892 1249634009374 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1249634009375 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1249634009376 dimer interface [polypeptide binding]; other site 1249634009377 phosphorylation site [posttranslational modification] 1249634009378 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1249634009379 ATP binding site [chemical binding]; other site 1249634009380 Mg2+ binding site [ion binding]; other site 1249634009381 G-X-G motif; other site 1249634009382 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 1249634009383 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634009384 active site 1249634009385 phosphorylation site [posttranslational modification] 1249634009386 intermolecular recognition site; other site 1249634009387 dimerization interface [polypeptide binding]; other site 1249634009388 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1249634009389 DNA binding site [nucleotide binding] 1249634009390 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1249634009391 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1249634009392 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1249634009393 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1249634009394 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1249634009395 catalytic residues [active] 1249634009396 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 1249634009397 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1249634009398 catalytic residues [active] 1249634009399 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 1249634009400 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1249634009401 DsbD alpha interface [polypeptide binding]; other site 1249634009402 catalytic residues [active] 1249634009403 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 1249634009404 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 1249634009405 ApbE family; Region: ApbE; pfam02424 1249634009406 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1249634009407 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1249634009408 HlyD family secretion protein; Region: HlyD_3; pfam13437 1249634009409 Outer membrane efflux protein; Region: OEP; pfam02321 1249634009410 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 1249634009411 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1249634009412 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1249634009413 dimer interface [polypeptide binding]; other site 1249634009414 active site 1249634009415 Uncharacterized conserved protein [Function unknown]; Region: COG4121 1249634009416 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 1249634009417 YfcL protein; Region: YfcL; pfam08891 1249634009418 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 1249634009419 hypothetical protein; Provisional; Region: PRK10621 1249634009420 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1249634009421 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 1249634009422 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 1249634009423 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1249634009424 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1249634009425 Tetramer interface [polypeptide binding]; other site 1249634009426 active site 1249634009427 FMN-binding site [chemical binding]; other site 1249634009428 HemK family putative methylases; Region: hemK_fam; TIGR00536 1249634009429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1249634009430 S-adenosylmethionine binding site [chemical binding]; other site 1249634009431 hypothetical protein; Provisional; Region: PRK04946 1249634009432 Smr domain; Region: Smr; pfam01713 1249634009433 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1249634009434 catalytic core [active] 1249634009435 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1249634009436 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1249634009437 substrate binding site [chemical binding]; other site 1249634009438 oxyanion hole (OAH) forming residues; other site 1249634009439 trimer interface [polypeptide binding]; other site 1249634009440 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1249634009441 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1249634009442 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1249634009443 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 1249634009444 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1249634009445 dimer interface [polypeptide binding]; other site 1249634009446 active site 1249634009447 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 1249634009448 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 1249634009449 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 1249634009450 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 1249634009451 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 1249634009452 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1249634009453 binding surface 1249634009454 TPR motif; other site 1249634009455 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 1249634009456 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 1249634009457 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1249634009458 catalytic residues [active] 1249634009459 central insert; other site 1249634009460 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 1249634009461 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 1249634009462 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 1249634009463 heme exporter protein CcmC; Region: ccmC; TIGR01191 1249634009464 heme exporter protein CcmB; Region: ccmB; TIGR01190 1249634009465 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 1249634009466 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 1249634009467 Walker A/P-loop; other site 1249634009468 ATP binding site [chemical binding]; other site 1249634009469 Q-loop/lid; other site 1249634009470 ABC transporter signature motif; other site 1249634009471 Walker B; other site 1249634009472 D-loop; other site 1249634009473 H-loop/switch region; other site 1249634009474 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 1249634009475 aminotransferase; Validated; Region: PRK08175 1249634009476 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1249634009477 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634009478 homodimer interface [polypeptide binding]; other site 1249634009479 catalytic residue [active] 1249634009480 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 1249634009481 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1249634009482 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634009483 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1249634009484 dimerization interface [polypeptide binding]; other site 1249634009485 substrate binding pocket [chemical binding]; other site 1249634009486 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 1249634009487 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1249634009488 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1249634009489 Histidine kinase; Region: His_kinase; pfam06580 1249634009490 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1249634009491 ATP binding site [chemical binding]; other site 1249634009492 Mg2+ binding site [ion binding]; other site 1249634009493 G-X-G motif; other site 1249634009494 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1249634009495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634009496 active site 1249634009497 phosphorylation site [posttranslational modification] 1249634009498 intermolecular recognition site; other site 1249634009499 dimerization interface [polypeptide binding]; other site 1249634009500 LytTr DNA-binding domain; Region: LytTR; pfam04397 1249634009501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634009502 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1249634009503 putative substrate translocation pore; other site 1249634009504 glucokinase; Provisional; Region: glk; PRK00292 1249634009505 glucokinase, proteobacterial type; Region: glk; TIGR00749 1249634009506 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1249634009507 aspartate racemase; Region: asp_race; TIGR00035 1249634009508 Predicted membrane protein [Function unknown]; Region: COG4125 1249634009509 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1249634009510 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1249634009511 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634009512 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634009513 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1249634009514 dimerization interface [polypeptide binding]; other site 1249634009515 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 1249634009516 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1249634009517 dimer interface [polypeptide binding]; other site 1249634009518 PYR/PP interface [polypeptide binding]; other site 1249634009519 TPP binding site [chemical binding]; other site 1249634009520 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1249634009521 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1249634009522 TPP-binding site [chemical binding]; other site 1249634009523 dimer interface [polypeptide binding]; other site 1249634009524 manganese transport protein MntH; Reviewed; Region: PRK00701 1249634009525 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1249634009526 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1249634009527 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1249634009528 Nucleoside recognition; Region: Gate; pfam07670 1249634009529 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1249634009530 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1249634009531 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1249634009532 HIGH motif; other site 1249634009533 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1249634009534 active site 1249634009535 KMSKS motif; other site 1249634009536 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1249634009537 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 1249634009538 putative NAD(P) binding site [chemical binding]; other site 1249634009539 active site 1249634009540 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1249634009541 hydrophobic substrate binding pocket; other site 1249634009542 Isochorismatase family; Region: Isochorismatase; pfam00857 1249634009543 active site 1249634009544 conserved cis-peptide bond; other site 1249634009545 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1249634009546 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 1249634009547 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1249634009548 acyl-activating enzyme (AAE) consensus motif; other site 1249634009549 active site 1249634009550 AMP binding site [chemical binding]; other site 1249634009551 substrate binding site [chemical binding]; other site 1249634009552 isochorismate synthase EntC; Provisional; Region: PRK15016 1249634009553 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1249634009554 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 1249634009555 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1249634009556 siderophore binding site; other site 1249634009557 H+ Antiporter protein; Region: 2A0121; TIGR00900 1249634009558 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1249634009559 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1249634009560 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1249634009561 ABC-ATPase subunit interface; other site 1249634009562 dimer interface [polypeptide binding]; other site 1249634009563 putative PBP binding regions; other site 1249634009564 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1249634009565 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1249634009566 ABC-ATPase subunit interface; other site 1249634009567 dimer interface [polypeptide binding]; other site 1249634009568 putative PBP binding regions; other site 1249634009569 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 1249634009570 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1249634009571 Walker A/P-loop; other site 1249634009572 ATP binding site [chemical binding]; other site 1249634009573 Q-loop/lid; other site 1249634009574 ABC transporter signature motif; other site 1249634009575 Walker B; other site 1249634009576 D-loop; other site 1249634009577 H-loop/switch region; other site 1249634009578 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1249634009579 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1249634009580 acyl-activating enzyme (AAE) consensus motif; other site 1249634009581 AMP binding site [chemical binding]; other site 1249634009582 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1249634009583 MbtH-like protein; Region: MbtH; pfam03621 1249634009584 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 1249634009585 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1249634009586 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1249634009587 outer membrane receptor FepA; Provisional; Region: PRK13524 1249634009588 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1249634009589 N-terminal plug; other site 1249634009590 ligand-binding site [chemical binding]; other site 1249634009591 acetolactate synthase; Reviewed; Region: PRK08617 1249634009592 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1249634009593 PYR/PP interface [polypeptide binding]; other site 1249634009594 dimer interface [polypeptide binding]; other site 1249634009595 TPP binding site [chemical binding]; other site 1249634009596 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1249634009597 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1249634009598 TPP-binding site [chemical binding]; other site 1249634009599 dimer interface [polypeptide binding]; other site 1249634009600 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 1249634009601 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634009602 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634009603 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1249634009604 putative effector binding pocket; other site 1249634009605 dimerization interface [polypeptide binding]; other site 1249634009606 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 1249634009607 FlxA-like protein; Region: FlxA; pfam14282 1249634009608 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634009609 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634009610 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1249634009611 putative dimerization interface [polypeptide binding]; other site 1249634009612 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1249634009613 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1249634009614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 1249634009615 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1249634009616 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1249634009617 nucleotide binding pocket [chemical binding]; other site 1249634009618 K-X-D-G motif; other site 1249634009619 catalytic site [active] 1249634009620 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1249634009621 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1249634009622 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1249634009623 Dimer interface [polypeptide binding]; other site 1249634009624 BRCT sequence motif; other site 1249634009625 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 1249634009626 cell division protein ZipA; Provisional; Region: PRK03427 1249634009627 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 1249634009628 FtsZ protein binding site [polypeptide binding]; other site 1249634009629 putative sulfate transport protein CysZ; Validated; Region: PRK04949 1249634009630 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1249634009631 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1249634009632 dimer interface [polypeptide binding]; other site 1249634009633 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634009634 catalytic residue [active] 1249634009635 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1249634009636 dimerization domain swap beta strand [polypeptide binding]; other site 1249634009637 regulatory protein interface [polypeptide binding]; other site 1249634009638 active site 1249634009639 regulatory phosphorylation site [posttranslational modification]; other site 1249634009640 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 1249634009641 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1249634009642 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1249634009643 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1249634009644 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1249634009645 HPr interaction site; other site 1249634009646 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1249634009647 active site 1249634009648 phosphorylation site [posttranslational modification] 1249634009649 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1249634009650 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1249634009651 dimerization interface [polypeptide binding]; other site 1249634009652 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1249634009653 dimer interface [polypeptide binding]; other site 1249634009654 phosphorylation site [posttranslational modification] 1249634009655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1249634009656 ATP binding site [chemical binding]; other site 1249634009657 Mg2+ binding site [ion binding]; other site 1249634009658 G-X-G motif; other site 1249634009659 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1249634009660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634009661 active site 1249634009662 phosphorylation site [posttranslational modification] 1249634009663 intermolecular recognition site; other site 1249634009664 dimerization interface [polypeptide binding]; other site 1249634009665 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1249634009666 DNA binding site [nucleotide binding] 1249634009667 cysteine synthase B; Region: cysM; TIGR01138 1249634009668 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1249634009669 dimer interface [polypeptide binding]; other site 1249634009670 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634009671 catalytic residue [active] 1249634009672 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 1249634009673 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1249634009674 Walker A/P-loop; other site 1249634009675 ATP binding site [chemical binding]; other site 1249634009676 Q-loop/lid; other site 1249634009677 ABC transporter signature motif; other site 1249634009678 Walker B; other site 1249634009679 D-loop; other site 1249634009680 H-loop/switch region; other site 1249634009681 TOBE-like domain; Region: TOBE_3; pfam12857 1249634009682 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1249634009683 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634009684 dimer interface [polypeptide binding]; other site 1249634009685 conserved gate region; other site 1249634009686 putative PBP binding loops; other site 1249634009687 ABC-ATPase subunit interface; other site 1249634009688 sulfate transport protein; Provisional; Region: cysT; CHL00187 1249634009689 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634009690 dimer interface [polypeptide binding]; other site 1249634009691 conserved gate region; other site 1249634009692 putative PBP binding loops; other site 1249634009693 ABC-ATPase subunit interface; other site 1249634009694 thiosulfate transporter subunit; Provisional; Region: PRK10852 1249634009695 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1249634009696 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1249634009697 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 1249634009698 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 1249634009699 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 1249634009700 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 1249634009701 putative acetyltransferase; Provisional; Region: PRK03624 1249634009702 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1249634009703 Coenzyme A binding pocket [chemical binding]; other site 1249634009704 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1249634009705 active site 1249634009706 metal binding site [ion binding]; metal-binding site 1249634009707 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1249634009708 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1249634009709 hypothetical protein; Validated; Region: PRK00124 1249634009710 Protein of unknown function, DUF399; Region: DUF399; cl01139 1249634009711 S-methylmethionine transporter; Provisional; Region: PRK11387 1249634009712 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1249634009713 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1249634009714 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1249634009715 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1249634009716 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1249634009717 putative NAD(P) binding site [chemical binding]; other site 1249634009718 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1249634009719 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1249634009720 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634009721 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1249634009722 dimerization interface [polypeptide binding]; other site 1249634009723 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1249634009724 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1249634009725 Homeodomain-like domain; Region: HTH_23; pfam13384 1249634009726 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1249634009727 DAK2 domain; Region: Dak2; pfam02734 1249634009728 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1249634009729 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1249634009730 short chain dehydrogenase; Provisional; Region: PRK06841 1249634009731 classical (c) SDRs; Region: SDR_c; cd05233 1249634009732 NAD(P) binding site [chemical binding]; other site 1249634009733 active site 1249634009734 polyol permease family; Region: 2A0118; TIGR00897 1249634009735 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634009736 putative substrate translocation pore; other site 1249634009737 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1249634009738 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1249634009739 NAD(P) binding site [chemical binding]; other site 1249634009740 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1249634009741 transaldolase-like protein; Provisional; Region: PTZ00411 1249634009742 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1249634009743 active site 1249634009744 dimer interface [polypeptide binding]; other site 1249634009745 catalytic residue [active] 1249634009746 transketolase; Reviewed; Region: PRK12753 1249634009747 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1249634009748 TPP-binding site [chemical binding]; other site 1249634009749 dimer interface [polypeptide binding]; other site 1249634009750 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1249634009751 PYR/PP interface [polypeptide binding]; other site 1249634009752 dimer interface [polypeptide binding]; other site 1249634009753 TPP binding site [chemical binding]; other site 1249634009754 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1249634009755 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1249634009756 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1249634009757 dimer interface [polypeptide binding]; other site 1249634009758 ADP-ribose binding site [chemical binding]; other site 1249634009759 active site 1249634009760 nudix motif; other site 1249634009761 metal binding site [ion binding]; metal-binding site 1249634009762 cytochrome c-type protein NapC; Provisional; Region: PRK10617 1249634009763 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 1249634009764 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 1249634009765 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 1249634009766 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1249634009767 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 1249634009768 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 1249634009769 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1249634009770 [4Fe-4S] binding site [ion binding]; other site 1249634009771 molybdopterin cofactor binding site; other site 1249634009772 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1249634009773 molybdopterin cofactor binding site; other site 1249634009774 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 1249634009775 ferredoxin-type protein NapF; Region: napF; TIGR00402 1249634009776 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 1249634009777 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1249634009778 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1249634009779 dimerization interface [polypeptide binding]; other site 1249634009780 Histidine kinase; Region: HisKA_3; pfam07730 1249634009781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1249634009782 ATP binding site [chemical binding]; other site 1249634009783 Mg2+ binding site [ion binding]; other site 1249634009784 G-X-G motif; other site 1249634009785 transcriptional regulator NarP; Provisional; Region: PRK10403 1249634009786 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634009787 active site 1249634009788 phosphorylation site [posttranslational modification] 1249634009789 intermolecular recognition site; other site 1249634009790 dimerization interface [polypeptide binding]; other site 1249634009791 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1249634009792 DNA binding residues [nucleotide binding] 1249634009793 dimerization interface [polypeptide binding]; other site 1249634009794 Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; cl11547 1249634009795 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 1249634009796 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1249634009797 Coenzyme A binding pocket [chemical binding]; other site 1249634009798 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1249634009799 ArsC family; Region: ArsC; pfam03960 1249634009800 putative catalytic residues [active] 1249634009801 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1249634009802 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1249634009803 metal binding site [ion binding]; metal-binding site 1249634009804 dimer interface [polypeptide binding]; other site 1249634009805 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1249634009806 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1249634009807 Uncharacterized protein family (UPF0370); Region: UPF0370; pfam13980 1249634009808 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 1249634009809 Helicase; Region: Helicase_RecD; pfam05127 1249634009810 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1249634009811 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 1249634009812 Predicted metalloprotease [General function prediction only]; Region: COG2321 1249634009813 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1249634009814 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1249634009815 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1249634009816 ATP binding site [chemical binding]; other site 1249634009817 active site 1249634009818 substrate binding site [chemical binding]; other site 1249634009819 lipoprotein; Provisional; Region: PRK11679 1249634009820 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 1249634009821 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1249634009822 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1249634009823 dimer interface [polypeptide binding]; other site 1249634009824 active site 1249634009825 catalytic residue [active] 1249634009826 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 1249634009827 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 1249634009828 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1249634009829 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1249634009830 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1249634009831 catalytic triad [active] 1249634009832 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1249634009833 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1249634009834 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1249634009835 Peptidase family M48; Region: Peptidase_M48; pfam01435 1249634009836 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1249634009837 TPR motif; other site 1249634009838 binding surface 1249634009839 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1249634009840 ArsC family; Region: ArsC; pfam03960 1249634009841 catalytic residues [active] 1249634009842 DNA replication initiation factor; Provisional; Region: PRK08084 1249634009843 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1249634009844 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1249634009845 uracil transporter; Provisional; Region: PRK10720 1249634009846 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1249634009847 active site 1249634009848 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1249634009849 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1249634009850 dimerization interface [polypeptide binding]; other site 1249634009851 putative ATP binding site [chemical binding]; other site 1249634009852 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1249634009853 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1249634009854 active site 1249634009855 substrate binding site [chemical binding]; other site 1249634009856 cosubstrate binding site; other site 1249634009857 catalytic site [active] 1249634009858 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 1249634009859 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1249634009860 Coenzyme A binding pocket [chemical binding]; other site 1249634009861 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1249634009862 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1249634009863 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 1249634009864 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1249634009865 Walker A/P-loop; other site 1249634009866 ATP binding site [chemical binding]; other site 1249634009867 Q-loop/lid; other site 1249634009868 ABC transporter signature motif; other site 1249634009869 Walker B; other site 1249634009870 D-loop; other site 1249634009871 H-loop/switch region; other site 1249634009872 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 1249634009873 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1249634009874 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634009875 dimer interface [polypeptide binding]; other site 1249634009876 conserved gate region; other site 1249634009877 putative PBP binding loops; other site 1249634009878 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1249634009879 ABC-ATPase subunit interface; other site 1249634009880 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 1249634009881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634009882 conserved gate region; other site 1249634009883 putative PBP binding loops; other site 1249634009884 ABC-ATPase subunit interface; other site 1249634009885 polyphosphate kinase; Provisional; Region: PRK05443 1249634009886 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1249634009887 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1249634009888 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 1249634009889 domain interface [polypeptide binding]; other site 1249634009890 active site 1249634009891 catalytic site [active] 1249634009892 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 1249634009893 domain interface [polypeptide binding]; other site 1249634009894 active site 1249634009895 catalytic site [active] 1249634009896 exopolyphosphatase; Provisional; Region: PRK10854 1249634009897 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1249634009898 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1249634009899 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1249634009900 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1249634009901 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 1249634009902 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1249634009903 MgtE intracellular N domain; Region: MgtE_N; smart00924 1249634009904 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1249634009905 Divalent cation transporter; Region: MgtE; pfam01769 1249634009906 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1249634009907 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1249634009908 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634009909 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1249634009910 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 1249634009911 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1249634009912 minor groove reading motif; other site 1249634009913 helix-hairpin-helix signature motif; other site 1249634009914 substrate binding pocket [chemical binding]; other site 1249634009915 putative chaperone; Provisional; Region: PRK11678 1249634009916 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1249634009917 nucleotide binding site [chemical binding]; other site 1249634009918 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1249634009919 SBD interface [polypeptide binding]; other site 1249634009920 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1249634009921 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1249634009922 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1249634009923 HlyD family secretion protein; Region: HlyD_3; pfam13437 1249634009924 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1249634009925 Protein export membrane protein; Region: SecD_SecF; cl14618 1249634009926 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1249634009927 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 1249634009928 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cl00653 1249634009929 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1249634009930 dimerization interface [polypeptide binding]; other site 1249634009931 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1249634009932 dimer interface [polypeptide binding]; other site 1249634009933 phosphorylation site [posttranslational modification] 1249634009934 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1249634009935 ATP binding site [chemical binding]; other site 1249634009936 Mg2+ binding site [ion binding]; other site 1249634009937 G-X-G motif; other site 1249634009938 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 1249634009939 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634009940 active site 1249634009941 phosphorylation site [posttranslational modification] 1249634009942 intermolecular recognition site; other site 1249634009943 dimerization interface [polypeptide binding]; other site 1249634009944 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1249634009945 DNA binding site [nucleotide binding] 1249634009946 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 1249634009947 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 1249634009948 putative protease; Provisional; Region: PRK15452 1249634009949 Peptidase family U32; Region: Peptidase_U32; pfam01136 1249634009950 lipid kinase; Reviewed; Region: PRK13054 1249634009951 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1249634009952 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 1249634009953 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 1249634009954 putative active site pocket [active] 1249634009955 putative metal binding site [ion binding]; other site 1249634009956 putative oxidoreductase; Provisional; Region: PRK10083 1249634009957 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1249634009958 putative NAD(P) binding site [chemical binding]; other site 1249634009959 catalytic Zn binding site [ion binding]; other site 1249634009960 structural Zn binding site [ion binding]; other site 1249634009961 D-galactonate transporter; Region: 2A0114; TIGR00893 1249634009962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634009963 putative substrate translocation pore; other site 1249634009964 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634009965 metabolite-proton symporter; Region: 2A0106; TIGR00883 1249634009966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634009967 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 1249634009968 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 1249634009969 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1249634009970 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 1249634009971 DNA-binding site [nucleotide binding]; DNA binding site 1249634009972 FCD domain; Region: FCD; pfam07729 1249634009973 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 1249634009974 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1249634009975 putative active site; other site 1249634009976 catalytic residue [active] 1249634009977 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 1249634009978 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1249634009979 putative active site [active] 1249634009980 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1249634009981 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816 1249634009982 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1249634009983 dimer interface [polypeptide binding]; other site 1249634009984 substrate binding site [chemical binding]; other site 1249634009985 ATP binding site [chemical binding]; other site 1249634009986 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1249634009987 substrate binding site [chemical binding]; other site 1249634009988 multimerization interface [polypeptide binding]; other site 1249634009989 ATP binding site [chemical binding]; other site 1249634009990 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1249634009991 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1249634009992 Coenzyme A binding pocket [chemical binding]; other site 1249634009993 PipA protein; Region: PipA; pfam07108 1249634009994 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634009995 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1249634009996 putative substrate translocation pore; other site 1249634009997 Predicted transcriptional regulators [Transcription]; Region: COG1733 1249634009998 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1249634009999 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1249634010000 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1249634010001 C-terminal domain interface [polypeptide binding]; other site 1249634010002 GSH binding site (G-site) [chemical binding]; other site 1249634010003 dimer interface [polypeptide binding]; other site 1249634010004 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1249634010005 N-terminal domain interface [polypeptide binding]; other site 1249634010006 dimer interface [polypeptide binding]; other site 1249634010007 substrate binding pocket (H-site) [chemical binding]; other site 1249634010008 short chain dehydrogenase; Provisional; Region: PRK06123 1249634010009 classical (c) SDRs; Region: SDR_c; cd05233 1249634010010 NAD(P) binding site [chemical binding]; other site 1249634010011 active site 1249634010012 Predicted transcriptional regulators [Transcription]; Region: COG1733 1249634010013 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1249634010014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634010015 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1249634010016 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1249634010017 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1249634010018 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1249634010019 inhibitor binding site; inhibition site 1249634010020 active site 1249634010021 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1249634010022 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1249634010023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1249634010024 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1249634010025 Walker A motif; other site 1249634010026 Walker A/P-loop; other site 1249634010027 ATP binding site [chemical binding]; other site 1249634010028 ATP binding site [chemical binding]; other site 1249634010029 Walker B motif; other site 1249634010030 GMP synthase; Reviewed; Region: guaA; PRK00074 1249634010031 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1249634010032 AMP/PPi binding site [chemical binding]; other site 1249634010033 candidate oxyanion hole; other site 1249634010034 catalytic triad [active] 1249634010035 potential glutamine specificity residues [chemical binding]; other site 1249634010036 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1249634010037 ATP Binding subdomain [chemical binding]; other site 1249634010038 Ligand Binding sites [chemical binding]; other site 1249634010039 Dimerization subdomain; other site 1249634010040 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1249634010041 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1249634010042 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1249634010043 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1249634010044 active site 1249634010045 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1249634010046 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1249634010047 generic binding surface II; other site 1249634010048 generic binding surface I; other site 1249634010049 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1249634010050 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1249634010051 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 1249634010052 putative active site [active] 1249634010053 putative catalytic site [active] 1249634010054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634010055 D-galactonate transporter; Region: 2A0114; TIGR00893 1249634010056 putative substrate translocation pore; other site 1249634010057 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1249634010058 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1249634010059 DNA binding site [nucleotide binding] 1249634010060 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1249634010061 ligand binding site [chemical binding]; other site 1249634010062 dimerization interface [polypeptide binding]; other site 1249634010063 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1249634010064 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1249634010065 active site 1249634010066 Zn binding site [ion binding]; other site 1249634010067 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 1249634010068 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 1249634010069 Predicted permeases [General function prediction only]; Region: COG0679 1249634010070 GTP-binding protein Der; Reviewed; Region: PRK00093 1249634010071 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1249634010072 G1 box; other site 1249634010073 GTP/Mg2+ binding site [chemical binding]; other site 1249634010074 Switch I region; other site 1249634010075 G2 box; other site 1249634010076 Switch II region; other site 1249634010077 G3 box; other site 1249634010078 G4 box; other site 1249634010079 G5 box; other site 1249634010080 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1249634010081 G1 box; other site 1249634010082 GTP/Mg2+ binding site [chemical binding]; other site 1249634010083 Switch I region; other site 1249634010084 G2 box; other site 1249634010085 G3 box; other site 1249634010086 Switch II region; other site 1249634010087 G4 box; other site 1249634010088 G5 box; other site 1249634010089 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 1249634010090 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 1249634010091 Trp docking motif [polypeptide binding]; other site 1249634010092 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1249634010093 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1249634010094 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1249634010095 dimer interface [polypeptide binding]; other site 1249634010096 motif 1; other site 1249634010097 active site 1249634010098 motif 2; other site 1249634010099 motif 3; other site 1249634010100 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1249634010101 anticodon binding site; other site 1249634010102 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1249634010103 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1249634010104 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1249634010105 cytoskeletal protein RodZ; Provisional; Region: PRK10856 1249634010106 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1249634010107 non-specific DNA binding site [nucleotide binding]; other site 1249634010108 salt bridge; other site 1249634010109 sequence-specific DNA binding site [nucleotide binding]; other site 1249634010110 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1249634010111 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 1249634010112 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1249634010113 binding surface 1249634010114 TPR motif; other site 1249634010115 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1249634010116 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1249634010117 FeS/SAM binding site; other site 1249634010118 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1249634010119 active site 1249634010120 multimer interface [polypeptide binding]; other site 1249634010121 SseB protein; Region: SseB; pfam07179 1249634010122 aminopeptidase B; Provisional; Region: PRK05015 1249634010123 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1249634010124 interface (dimer of trimers) [polypeptide binding]; other site 1249634010125 Substrate-binding/catalytic site; other site 1249634010126 Zn-binding sites [ion binding]; other site 1249634010127 hypothetical protein; Provisional; Region: PRK10721 1249634010128 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1249634010129 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1249634010130 catalytic loop [active] 1249634010131 iron binding site [ion binding]; other site 1249634010132 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1249634010133 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 1249634010134 nucleotide binding site [chemical binding]; other site 1249634010135 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1249634010136 SBD interface [polypeptide binding]; other site 1249634010137 co-chaperone HscB; Provisional; Region: hscB; PRK05014 1249634010138 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1249634010139 HSP70 interaction site [polypeptide binding]; other site 1249634010140 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 1249634010141 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1249634010142 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1249634010143 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1249634010144 trimerization site [polypeptide binding]; other site 1249634010145 active site 1249634010146 cysteine desulfurase; Provisional; Region: PRK14012 1249634010147 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1249634010148 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1249634010149 catalytic residue [active] 1249634010150 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 1249634010151 Rrf2 family protein; Region: rrf2_super; TIGR00738 1249634010152 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 1249634010153 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1249634010154 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1249634010155 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1249634010156 active site 1249634010157 dimerization interface [polypeptide binding]; other site 1249634010158 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 1249634010159 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 1249634010160 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 1249634010161 PRD domain; Region: PRD; pfam00874 1249634010162 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1249634010163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634010164 putative substrate translocation pore; other site 1249634010165 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1249634010166 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1249634010167 dimer interface [polypeptide binding]; other site 1249634010168 active site 1249634010169 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1249634010170 folate binding site [chemical binding]; other site 1249634010171 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1249634010172 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1249634010173 heme-binding site [chemical binding]; other site 1249634010174 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1249634010175 FAD binding pocket [chemical binding]; other site 1249634010176 FAD binding motif [chemical binding]; other site 1249634010177 phosphate binding motif [ion binding]; other site 1249634010178 beta-alpha-beta structure motif; other site 1249634010179 NAD binding pocket [chemical binding]; other site 1249634010180 Heme binding pocket [chemical binding]; other site 1249634010181 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 1249634010182 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1249634010183 NAD synthetase; Provisional; Region: PRK13981 1249634010184 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1249634010185 multimer interface [polypeptide binding]; other site 1249634010186 active site 1249634010187 catalytic triad [active] 1249634010188 protein interface 1 [polypeptide binding]; other site 1249634010189 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1249634010190 homodimer interface [polypeptide binding]; other site 1249634010191 NAD binding pocket [chemical binding]; other site 1249634010192 ATP binding pocket [chemical binding]; other site 1249634010193 Mg binding site [ion binding]; other site 1249634010194 active-site loop [active] 1249634010195 response regulator GlrR; Provisional; Region: PRK15115 1249634010196 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634010197 active site 1249634010198 phosphorylation site [posttranslational modification] 1249634010199 intermolecular recognition site; other site 1249634010200 dimerization interface [polypeptide binding]; other site 1249634010201 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1249634010202 Walker A motif; other site 1249634010203 ATP binding site [chemical binding]; other site 1249634010204 Walker B motif; other site 1249634010205 arginine finger; other site 1249634010206 hypothetical protein; Provisional; Region: PRK10722 1249634010207 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1249634010208 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1249634010209 dimer interface [polypeptide binding]; other site 1249634010210 phosphorylation site [posttranslational modification] 1249634010211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1249634010212 ATP binding site [chemical binding]; other site 1249634010213 Mg2+ binding site [ion binding]; other site 1249634010214 G-X-G motif; other site 1249634010215 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1249634010216 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1249634010217 dimerization interface [polypeptide binding]; other site 1249634010218 ATP binding site [chemical binding]; other site 1249634010219 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1249634010220 dimerization interface [polypeptide binding]; other site 1249634010221 ATP binding site [chemical binding]; other site 1249634010222 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1249634010223 putative active site [active] 1249634010224 catalytic triad [active] 1249634010225 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 1249634010226 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1249634010227 substrate binding pocket [chemical binding]; other site 1249634010228 membrane-bound complex binding site; other site 1249634010229 hinge residues; other site 1249634010230 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1249634010231 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1249634010232 catalytic residue [active] 1249634010233 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1249634010234 nucleoside/Zn binding site; other site 1249634010235 dimer interface [polypeptide binding]; other site 1249634010236 catalytic motif [active] 1249634010237 putative alcohol dehydrogenase; Provisional; Region: PRK09860 1249634010238 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1249634010239 dimer interface [polypeptide binding]; other site 1249634010240 active site 1249634010241 metal binding site [ion binding]; metal-binding site 1249634010242 hypothetical protein; Provisional; Region: PRK11590 1249634010243 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1249634010244 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1249634010245 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1249634010246 active site turn [active] 1249634010247 phosphorylation site [posttranslational modification] 1249634010248 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1249634010249 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1249634010250 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1249634010251 putative active site [active] 1249634010252 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1249634010253 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 1249634010254 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1249634010255 putative active site [active] 1249634010256 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1249634010257 trimer interface [polypeptide binding]; other site 1249634010258 active site 1249634010259 substrate binding site [chemical binding]; other site 1249634010260 CoA binding site [chemical binding]; other site 1249634010261 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1249634010262 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1249634010263 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1249634010264 active site 1249634010265 hydrophilic channel; other site 1249634010266 dimerization interface [polypeptide binding]; other site 1249634010267 catalytic residues [active] 1249634010268 active site lid [active] 1249634010269 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1249634010270 Recombination protein O N terminal; Region: RecO_N; pfam11967 1249634010271 Recombination protein O C terminal; Region: RecO_C; pfam02565 1249634010272 GTPase Era; Reviewed; Region: era; PRK00089 1249634010273 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1249634010274 G1 box; other site 1249634010275 GTP/Mg2+ binding site [chemical binding]; other site 1249634010276 Switch I region; other site 1249634010277 G2 box; other site 1249634010278 Switch II region; other site 1249634010279 G3 box; other site 1249634010280 G4 box; other site 1249634010281 G5 box; other site 1249634010282 KH domain; Region: KH_2; pfam07650 1249634010283 ribonuclease III; Reviewed; Region: rnc; PRK00102 1249634010284 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1249634010285 dimerization interface [polypeptide binding]; other site 1249634010286 active site 1249634010287 metal binding site [ion binding]; metal-binding site 1249634010288 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1249634010289 dsRNA binding site [nucleotide binding]; other site 1249634010290 signal peptidase I; Provisional; Region: PRK10861 1249634010291 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1249634010292 Catalytic site [active] 1249634010293 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1249634010294 GTP-binding protein LepA; Provisional; Region: PRK05433 1249634010295 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1249634010296 G1 box; other site 1249634010297 putative GEF interaction site [polypeptide binding]; other site 1249634010298 GTP/Mg2+ binding site [chemical binding]; other site 1249634010299 Switch I region; other site 1249634010300 G2 box; other site 1249634010301 G3 box; other site 1249634010302 Switch II region; other site 1249634010303 G4 box; other site 1249634010304 G5 box; other site 1249634010305 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1249634010306 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1249634010307 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1249634010308 SoxR reducing system protein RseC; Provisional; Region: PRK10862 1249634010309 anti-sigma E factor; Provisional; Region: rseB; PRK09455 1249634010310 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 1249634010311 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 1249634010312 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 1249634010313 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 1249634010314 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 1249634010315 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1249634010316 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1249634010317 DNA binding residues [nucleotide binding] 1249634010318 L-aspartate oxidase; Provisional; Region: PRK09077 1249634010319 L-aspartate oxidase; Provisional; Region: PRK06175 1249634010320 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1249634010321 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1249634010322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1249634010323 S-adenosylmethionine binding site [chemical binding]; other site 1249634010324 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1249634010325 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1249634010326 ATP binding site [chemical binding]; other site 1249634010327 Mg++ binding site [ion binding]; other site 1249634010328 motif III; other site 1249634010329 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1249634010330 nucleotide binding region [chemical binding]; other site 1249634010331 ATP-binding site [chemical binding]; other site 1249634010332 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1249634010333 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1249634010334 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1249634010335 nucleophilic elbow; other site 1249634010336 catalytic triad; other site 1249634010337 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1249634010338 Helix-turn-helix domain; Region: HTH_28; pfam13518 1249634010339 putative transposase OrfB; Reviewed; Region: PHA02517 1249634010340 Integrase core domain; Region: rve; pfam00665 1249634010341 Integrase core domain; Region: rve_3; pfam13683 1249634010342 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 1249634010343 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1249634010344 ligand binding site [chemical binding]; other site 1249634010345 active site 1249634010346 UGI interface [polypeptide binding]; other site 1249634010347 catalytic site [active] 1249634010348 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1249634010349 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1249634010350 dimer interface [polypeptide binding]; other site 1249634010351 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1249634010352 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 1249634010353 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1249634010354 recombination and repair protein; Provisional; Region: PRK10869 1249634010355 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1249634010356 Walker A/P-loop; other site 1249634010357 ATP binding site [chemical binding]; other site 1249634010358 Q-loop/lid; other site 1249634010359 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1249634010360 Q-loop/lid; other site 1249634010361 ABC transporter signature motif; other site 1249634010362 Walker B; other site 1249634010363 D-loop; other site 1249634010364 H-loop/switch region; other site 1249634010365 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 1249634010366 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1249634010367 hypothetical protein; Validated; Region: PRK01777 1249634010368 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1249634010369 putative coenzyme Q binding site [chemical binding]; other site 1249634010370 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1249634010371 SmpB-tmRNA interface; other site 1249634010372 integrase; Provisional; Region: PRK09692 1249634010373 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1249634010374 active site 1249634010375 Int/Topo IB signature motif; other site 1249634010376 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634010377 active site 1249634010378 phosphorylation site [posttranslational modification] 1249634010379 intermolecular recognition site; other site 1249634010380 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1249634010381 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1249634010382 active site 1249634010383 phosphorylation site [posttranslational modification] 1249634010384 intermolecular recognition site; other site 1249634010385 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1249634010386 Transposase; Region: HTH_Tnp_1; pfam01527 1249634010387 putative transposase OrfB; Reviewed; Region: PHA02517 1249634010388 HTH-like domain; Region: HTH_21; pfam13276 1249634010389 Integrase core domain; Region: rve; pfam00665 1249634010390 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1249634010391 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 1249634010392 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 1249634010393 Domain of unknown function (DUF932); Region: DUF932; pfam06067 1249634010394 Antirestriction protein; Region: Antirestrict; pfam03230 1249634010395 hypothetical protein; Reviewed; Region: PRK00024 1249634010396 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1249634010397 MPN+ (JAMM) motif; other site 1249634010398 Zinc-binding site [ion binding]; other site 1249634010399 Protein of unknown function (DUF987); Region: DUF987; pfam06174 1249634010400 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 1249634010401 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1249634010402 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 1249634010403 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1249634010404 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1249634010405 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1249634010406 S-adenosylmethionine binding site [chemical binding]; other site 1249634010407 Predicted membrane protein [Function unknown]; Region: COG2259 1249634010408 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 1249634010409 dimer interface [polypeptide binding]; other site 1249634010410 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1249634010411 metal binding site [ion binding]; metal-binding site 1249634010412 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1249634010413 Smr domain; Region: Smr; pfam01713 1249634010414 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 1249634010415 hypothetical protein; Provisional; Region: PRK10556 1249634010416 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1249634010417 catalytic residues [active] 1249634010418 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1249634010419 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1249634010420 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1249634010421 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1249634010422 active site 1249634010423 dimer interface [polypeptide binding]; other site 1249634010424 catalytic residues [active] 1249634010425 effector binding site; other site 1249634010426 R2 peptide binding site; other site 1249634010427 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1249634010428 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1249634010429 dimer interface [polypeptide binding]; other site 1249634010430 putative radical transfer pathway; other site 1249634010431 diiron center [ion binding]; other site 1249634010432 tyrosyl radical; other site 1249634010433 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 1249634010434 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1249634010435 PAS domain; Region: PAS; smart00091 1249634010436 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1249634010437 ATP binding site [chemical binding]; other site 1249634010438 Mg2+ binding site [ion binding]; other site 1249634010439 G-X-G motif; other site 1249634010440 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1249634010441 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634010442 active site 1249634010443 phosphorylation site [posttranslational modification] 1249634010444 intermolecular recognition site; other site 1249634010445 dimerization interface [polypeptide binding]; other site 1249634010446 Transcriptional regulator; Region: CitT; pfam12431 1249634010447 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 1249634010448 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1249634010449 Walker A/P-loop; other site 1249634010450 ATP binding site [chemical binding]; other site 1249634010451 Q-loop/lid; other site 1249634010452 ABC transporter signature motif; other site 1249634010453 Walker B; other site 1249634010454 D-loop; other site 1249634010455 H-loop/switch region; other site 1249634010456 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1249634010457 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1249634010458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634010459 dimer interface [polypeptide binding]; other site 1249634010460 conserved gate region; other site 1249634010461 putative PBP binding loops; other site 1249634010462 ABC-ATPase subunit interface; other site 1249634010463 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 1249634010464 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1249634010465 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634010466 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634010467 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 1249634010468 putative dimerization interface [polypeptide binding]; other site 1249634010469 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1249634010470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634010471 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1249634010472 putative L-valine exporter; Provisional; Region: PRK10408 1249634010473 transcriptional repressor MprA; Provisional; Region: PRK10870 1249634010474 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1249634010475 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1249634010476 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 1249634010477 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1249634010478 HlyD family secretion protein; Region: HlyD_3; pfam13437 1249634010479 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1249634010480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634010481 putative substrate translocation pore; other site 1249634010482 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634010483 putative methyltransferase; Provisional; Region: PRK10864 1249634010484 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1249634010485 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1249634010486 thioredoxin 2; Provisional; Region: PRK10996 1249634010487 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 1249634010488 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1249634010489 catalytic residues [active] 1249634010490 Uncharacterized conserved protein [Function unknown]; Region: COG3148 1249634010491 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1249634010492 CoA binding domain; Region: CoA_binding_2; pfam13380 1249634010493 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1249634010494 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1249634010495 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1249634010496 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1249634010497 Coenzyme A binding pocket [chemical binding]; other site 1249634010498 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 1249634010499 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 1249634010500 domain interface [polypeptide binding]; other site 1249634010501 putative active site [active] 1249634010502 catalytic site [active] 1249634010503 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 1249634010504 domain interface [polypeptide binding]; other site 1249634010505 putative active site [active] 1249634010506 catalytic site [active] 1249634010507 lipoprotein; Provisional; Region: PRK10759 1249634010508 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1249634010509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634010510 putative substrate translocation pore; other site 1249634010511 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 1249634010512 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1249634010513 active site 1249634010514 motif I; other site 1249634010515 motif II; other site 1249634010516 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1249634010517 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1249634010518 Walker A/P-loop; other site 1249634010519 ATP binding site [chemical binding]; other site 1249634010520 Q-loop/lid; other site 1249634010521 ABC transporter signature motif; other site 1249634010522 Walker B; other site 1249634010523 D-loop; other site 1249634010524 H-loop/switch region; other site 1249634010525 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1249634010526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634010527 dimer interface [polypeptide binding]; other site 1249634010528 conserved gate region; other site 1249634010529 ABC-ATPase subunit interface; other site 1249634010530 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 1249634010531 lipoprotein, YaeC family; Region: TIGR00363 1249634010532 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 1249634010533 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1249634010534 homodimer interaction site [polypeptide binding]; other site 1249634010535 cofactor binding site; other site 1249634010536 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1249634010537 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1249634010538 dimer interface [polypeptide binding]; other site 1249634010539 motif 1; other site 1249634010540 active site 1249634010541 motif 2; other site 1249634010542 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1249634010543 putative deacylase active site [active] 1249634010544 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1249634010545 active site 1249634010546 motif 3; other site 1249634010547 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1249634010548 anticodon binding site; other site 1249634010549 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 1249634010550 NlpE N-terminal domain; Region: NlpE; pfam04170 1249634010551 hypothetical protein; Provisional; Region: PRK09256 1249634010552 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1249634010553 YaeQ protein; Region: YaeQ; pfam07152 1249634010554 hypothetical protein; Provisional; Region: PRK04964 1249634010555 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 1249634010556 Cytochrome c; Region: Cytochrom_C; cl11414 1249634010557 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 1249634010558 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1249634010559 TilS substrate binding domain; Region: TilS; pfam09179 1249634010560 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 1249634010561 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1249634010562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634010563 putative substrate translocation pore; other site 1249634010564 POT family; Region: PTR2; cl17359 1249634010565 lysine decarboxylase CadA; Provisional; Region: PRK15400 1249634010566 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1249634010567 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1249634010568 homodimer interface [polypeptide binding]; other site 1249634010569 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634010570 catalytic residue [active] 1249634010571 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1249634010572 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 1249634010573 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 1249634010574 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1249634010575 DNA binding site [nucleotide binding] 1249634010576 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1249634010577 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1249634010578 putative metal binding site [ion binding]; other site 1249634010579 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1249634010580 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1249634010581 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1249634010582 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1249634010583 putative active site [active] 1249634010584 putative PHP Thumb interface [polypeptide binding]; other site 1249634010585 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1249634010586 generic binding surface II; other site 1249634010587 generic binding surface I; other site 1249634010588 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1249634010589 RNA/DNA hybrid binding site [nucleotide binding]; other site 1249634010590 active site 1249634010591 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1249634010592 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1249634010593 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1249634010594 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1249634010595 active site 1249634010596 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1249634010597 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1249634010598 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1249634010599 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1249634010600 trimer interface [polypeptide binding]; other site 1249634010601 active site 1249634010602 UDP-GlcNAc binding site [chemical binding]; other site 1249634010603 lipid binding site [chemical binding]; lipid-binding site 1249634010604 periplasmic chaperone; Provisional; Region: PRK10780 1249634010605 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1249634010606 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 1249634010607 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1249634010608 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1249634010609 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1249634010610 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1249634010611 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1249634010612 Surface antigen; Region: Bac_surface_Ag; pfam01103 1249634010613 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1249634010614 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1249634010615 active site 1249634010616 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1249634010617 protein binding site [polypeptide binding]; other site 1249634010618 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1249634010619 protein binding site [polypeptide binding]; other site 1249634010620 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1249634010621 putative substrate binding region [chemical binding]; other site 1249634010622 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 1249634010623 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1249634010624 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1249634010625 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1249634010626 catalytic residue [active] 1249634010627 putative FPP diphosphate binding site; other site 1249634010628 putative FPP binding hydrophobic cleft; other site 1249634010629 dimer interface [polypeptide binding]; other site 1249634010630 putative IPP diphosphate binding site; other site 1249634010631 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1249634010632 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1249634010633 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1249634010634 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1249634010635 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1249634010636 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1249634010637 hinge region; other site 1249634010638 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1249634010639 putative nucleotide binding site [chemical binding]; other site 1249634010640 uridine monophosphate binding site [chemical binding]; other site 1249634010641 homohexameric interface [polypeptide binding]; other site 1249634010642 elongation factor Ts; Provisional; Region: tsf; PRK09377 1249634010643 UBA/TS-N domain; Region: UBA; pfam00627 1249634010644 Elongation factor TS; Region: EF_TS; pfam00889 1249634010645 Elongation factor TS; Region: EF_TS; pfam00889 1249634010646 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1249634010647 rRNA interaction site [nucleotide binding]; other site 1249634010648 S8 interaction site; other site 1249634010649 putative laminin-1 binding site; other site 1249634010650 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1249634010651 active site 1249634010652 PII uridylyl-transferase; Provisional; Region: PRK05007 1249634010653 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1249634010654 metal binding triad; other site 1249634010655 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1249634010656 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1249634010657 Zn2+ binding site [ion binding]; other site 1249634010658 Mg2+ binding site [ion binding]; other site 1249634010659 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1249634010660 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1249634010661 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1249634010662 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1249634010663 trimer interface [polypeptide binding]; other site 1249634010664 active site 1249634010665 substrate binding site [chemical binding]; other site 1249634010666 CoA binding site [chemical binding]; other site 1249634010667 hypothetical protein; Provisional; Region: PRK13677 1249634010668 flavodoxin; Provisional; Region: PRK08105 1249634010669 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1249634010670 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 1249634010671 probable active site [active] 1249634010672 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 1249634010673 benzoate transport; Region: 2A0115; TIGR00895 1249634010674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634010675 putative substrate translocation pore; other site 1249634010676 SecY interacting protein Syd; Provisional; Region: PRK04968 1249634010677 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 1249634010678 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 1249634010679 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1249634010680 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1249634010681 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 1249634010682 flap endonuclease-like protein; Provisional; Region: PRK09482 1249634010683 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1249634010684 active site 1249634010685 metal binding site 1 [ion binding]; metal-binding site 1249634010686 putative 5' ssDNA interaction site; other site 1249634010687 metal binding site 3; metal-binding site 1249634010688 metal binding site 2 [ion binding]; metal-binding site 1249634010689 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1249634010690 putative DNA binding site [nucleotide binding]; other site 1249634010691 putative metal binding site [ion binding]; other site 1249634010692 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 1249634010693 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1249634010694 hypothetical protein; Provisional; Region: PRK10873 1249634010695 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1249634010696 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634010697 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1249634010698 dimerization interface [polypeptide binding]; other site 1249634010699 substrate binding pocket [chemical binding]; other site 1249634010700 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1249634010701 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1249634010702 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1249634010703 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1249634010704 catalytic residue [active] 1249634010705 cysteine desulfurase, sulfur acceptor subunit CsdE; Region: FeS_syn_CsdE; TIGR03391 1249634010706 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 1249634010707 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1249634010708 putative ATP binding site [chemical binding]; other site 1249634010709 putative substrate interface [chemical binding]; other site 1249634010710 murein transglycosylase A; Provisional; Region: mltA; PRK11162 1249634010711 MltA specific insert domain; Region: MltA; smart00925 1249634010712 3D domain; Region: 3D; pfam06725 1249634010713 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 1249634010714 AMIN domain; Region: AMIN; pfam11741 1249634010715 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1249634010716 active site 1249634010717 metal binding site [ion binding]; metal-binding site 1249634010718 N-acetylglutamate synthase; Validated; Region: PRK05279 1249634010719 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1249634010720 putative feedback inhibition sensing region; other site 1249634010721 putative nucleotide binding site [chemical binding]; other site 1249634010722 putative substrate binding site [chemical binding]; other site 1249634010723 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1249634010724 Coenzyme A binding pocket [chemical binding]; other site 1249634010725 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 1249634010726 AAA domain; Region: AAA_30; pfam13604 1249634010727 Family description; Region: UvrD_C_2; pfam13538 1249634010728 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 1249634010729 protease3; Provisional; Region: PRK15101 1249634010730 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1249634010731 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1249634010732 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1249634010733 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 1249634010734 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1249634010735 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 1249634010736 Protein of unknown function (DUF2509); Region: DUF2509; cl11672 1249634010737 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 1249634010738 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1249634010739 hypothetical protein; Provisional; Region: PRK10506 1249634010740 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1249634010741 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1249634010742 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1249634010743 dimerization interface [polypeptide binding]; other site 1249634010744 active site 1249634010745 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1249634010746 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 1249634010747 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1249634010748 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1249634010749 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1249634010750 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1249634010751 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1249634010752 putative active site [active] 1249634010753 Ap4A binding site [chemical binding]; other site 1249634010754 nudix motif; other site 1249634010755 putative metal binding site [ion binding]; other site 1249634010756 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 1249634010757 putative DNA-binding cleft [nucleotide binding]; other site 1249634010758 putative DNA clevage site; other site 1249634010759 molecular lever; other site 1249634010760 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1249634010761 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1249634010762 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1249634010763 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1249634010764 active site 1249634010765 catalytic tetrad [active] 1249634010766 lysophospholipid transporter LplT; Provisional; Region: PRK11195 1249634010767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634010768 putative substrate translocation pore; other site 1249634010769 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 1249634010770 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1249634010771 putative acyl-acceptor binding pocket; other site 1249634010772 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 1249634010773 acyl-activating enzyme (AAE) consensus motif; other site 1249634010774 putative AMP binding site [chemical binding]; other site 1249634010775 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1249634010776 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1249634010777 molybdopterin cofactor binding site [chemical binding]; other site 1249634010778 substrate binding site [chemical binding]; other site 1249634010779 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1249634010780 molybdopterin cofactor binding site; other site 1249634010781 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 1249634010782 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1249634010783 DNA binding site [nucleotide binding] 1249634010784 domain linker motif; other site 1249634010785 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1249634010786 dimerization interface (closed form) [polypeptide binding]; other site 1249634010787 ligand binding site [chemical binding]; other site 1249634010788 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 1249634010789 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1249634010790 DNA-binding site [nucleotide binding]; DNA binding site 1249634010791 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1249634010792 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1249634010793 active site 1249634010794 P-loop; other site 1249634010795 phosphorylation site [posttranslational modification] 1249634010796 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1249634010797 beta-galactosidase; Region: BGL; TIGR03356 1249634010798 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1249634010799 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1249634010800 methionine cluster; other site 1249634010801 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 1249634010802 active site 1249634010803 phosphorylation site [posttranslational modification] 1249634010804 metal binding site [ion binding]; metal-binding site 1249634010805 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1249634010806 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1249634010807 DNA binding site [nucleotide binding] 1249634010808 domain linker motif; other site 1249634010809 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1249634010810 dimerization interface (closed form) [polypeptide binding]; other site 1249634010811 ligand binding site [chemical binding]; other site 1249634010812 diaminopimelate decarboxylase; Provisional; Region: PRK11165 1249634010813 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1249634010814 active site 1249634010815 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1249634010816 substrate binding site [chemical binding]; other site 1249634010817 catalytic residues [active] 1249634010818 dimer interface [polypeptide binding]; other site 1249634010819 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1249634010820 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634010821 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1249634010822 dimerization interface [polypeptide binding]; other site 1249634010823 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1249634010824 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634010825 putative substrate translocation pore; other site 1249634010826 transcriptional activator TtdR; Provisional; Region: PRK09801 1249634010827 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634010828 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1249634010829 putative effector binding pocket; other site 1249634010830 dimerization interface [polypeptide binding]; other site 1249634010831 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1249634010832 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 1249634010833 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1249634010834 catalytic residues [active] 1249634010835 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1249634010836 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1249634010837 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1249634010838 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 1249634010839 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1249634010840 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1249634010841 Walker A/P-loop; other site 1249634010842 ATP binding site [chemical binding]; other site 1249634010843 Q-loop/lid; other site 1249634010844 ABC transporter signature motif; other site 1249634010845 Walker B; other site 1249634010846 D-loop; other site 1249634010847 H-loop/switch region; other site 1249634010848 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1249634010849 active site 1249634010850 DNA binding site [nucleotide binding] 1249634010851 Int/Topo IB signature motif; other site 1249634010852 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1249634010853 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1249634010854 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1249634010855 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1249634010856 DNA binding residues [nucleotide binding] 1249634010857 dimerization interface [polypeptide binding]; other site 1249634010858 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1249634010859 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1249634010860 DNA binding residues [nucleotide binding] 1249634010861 dimerization interface [polypeptide binding]; other site 1249634010862 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1249634010863 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1249634010864 intermolecular recognition site; other site 1249634010865 active site 1249634010866 dimerization interface [polypeptide binding]; other site 1249634010867 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1249634010868 DNA binding residues [nucleotide binding] 1249634010869 dimerization interface [polypeptide binding]; other site 1249634010870 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1249634010871 Fimbrial protein; Region: Fimbrial; cl01416 1249634010872 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1249634010873 PapC N-terminal domain; Region: PapC_N; pfam13954 1249634010874 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1249634010875 PapC C-terminal domain; Region: PapC_C; pfam13953 1249634010876 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1249634010877 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1249634010878 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1249634010879 Fimbrial protein; Region: Fimbrial; cl01416 1249634010880 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1249634010881 active site 1249634010882 DNA binding site [nucleotide binding] 1249634010883 Int/Topo IB signature motif; other site 1249634010884 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1249634010885 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1249634010886 NAD(P) binding site [chemical binding]; other site 1249634010887 active site 1249634010888 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1249634010889 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1249634010890 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1249634010891 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1249634010892 dimer interface [polypeptide binding]; other site 1249634010893 active site 1249634010894 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1249634010895 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1249634010896 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1249634010897 Walker A/P-loop; other site 1249634010898 ATP binding site [chemical binding]; other site 1249634010899 Q-loop/lid; other site 1249634010900 ABC transporter signature motif; other site 1249634010901 Walker B; other site 1249634010902 D-loop; other site 1249634010903 H-loop/switch region; other site 1249634010904 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1249634010905 FtsX-like permease family; Region: FtsX; pfam02687 1249634010906 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1249634010907 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1249634010908 HlyD family secretion protein; Region: HlyD_3; pfam13437 1249634010909 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1249634010910 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1249634010911 putative active site [active] 1249634010912 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1249634010913 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1249634010914 Walker A/P-loop; other site 1249634010915 ATP binding site [chemical binding]; other site 1249634010916 Q-loop/lid; other site 1249634010917 ABC transporter signature motif; other site 1249634010918 Walker B; other site 1249634010919 D-loop; other site 1249634010920 H-loop/switch region; other site 1249634010921 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1249634010922 putative acyl-acceptor binding pocket; other site 1249634010923 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1249634010924 catalytic residues [active] 1249634010925 hinge region; other site 1249634010926 alpha helical domain; other site 1249634010927 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634010928 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634010929 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1249634010930 putative effector binding pocket; other site 1249634010931 dimerization interface [polypeptide binding]; other site 1249634010932 L-lactate permease; Region: Lactate_perm; cl00701 1249634010933 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1249634010934 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 1249634010935 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1249634010936 phosphate binding site [ion binding]; other site 1249634010937 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1249634010938 Peptidase family M23; Region: Peptidase_M23; pfam01551 1249634010939 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1249634010940 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1249634010941 putative C-terminal domain interface [polypeptide binding]; other site 1249634010942 putative GSH binding site (G-site) [chemical binding]; other site 1249634010943 putative dimer interface [polypeptide binding]; other site 1249634010944 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1249634010945 putative N-terminal domain interface [polypeptide binding]; other site 1249634010946 putative dimer interface [polypeptide binding]; other site 1249634010947 putative substrate binding pocket (H-site) [chemical binding]; other site 1249634010948 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1249634010949 HAMP domain; Region: HAMP; pfam00672 1249634010950 dimerization interface [polypeptide binding]; other site 1249634010951 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1249634010952 dimer interface [polypeptide binding]; other site 1249634010953 phosphorylation site [posttranslational modification] 1249634010954 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1249634010955 ATP binding site [chemical binding]; other site 1249634010956 Mg2+ binding site [ion binding]; other site 1249634010957 G-X-G motif; other site 1249634010958 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1249634010959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634010960 active site 1249634010961 phosphorylation site [posttranslational modification] 1249634010962 intermolecular recognition site; other site 1249634010963 dimerization interface [polypeptide binding]; other site 1249634010964 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1249634010965 DNA binding site [nucleotide binding] 1249634010966 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1249634010967 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1249634010968 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1249634010969 Moco binding site; other site 1249634010970 metal coordination site [ion binding]; other site 1249634010971 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1249634010972 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1249634010973 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1249634010974 active site 1249634010975 DNA binding site [nucleotide binding] 1249634010976 Int/Topo IB signature motif; other site 1249634010977 HNH endonuclease; Region: HNH_2; pfam13391 1249634010978 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1249634010979 DNA-binding interface [nucleotide binding]; DNA binding site 1249634010980 IS2 transposase TnpB; Reviewed; Region: PRK09409 1249634010981 HTH-like domain; Region: HTH_21; pfam13276 1249634010982 Integrase core domain; Region: rve; pfam00665 1249634010983 Integrase core domain; Region: rve_3; pfam13683 1249634010984 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 1249634010985 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1249634010986 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1249634010987 dimer interface [polypeptide binding]; other site 1249634010988 putative anticodon binding site; other site 1249634010989 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1249634010990 motif 1; other site 1249634010991 active site 1249634010992 motif 2; other site 1249634010993 motif 3; other site 1249634010994 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1249634010995 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1249634010996 RF-1 domain; Region: RF-1; pfam00472 1249634010997 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1249634010998 DHH family; Region: DHH; pfam01368 1249634010999 DHHA1 domain; Region: DHHA1; pfam02272 1249634011000 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 1249634011001 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1249634011002 dimerization domain [polypeptide binding]; other site 1249634011003 dimer interface [polypeptide binding]; other site 1249634011004 catalytic residues [active] 1249634011005 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1249634011006 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1249634011007 active site 1249634011008 Int/Topo IB signature motif; other site 1249634011009 flavodoxin FldB; Provisional; Region: PRK12359 1249634011010 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 1249634011011 hypothetical protein; Provisional; Region: PRK10878 1249634011012 putative global regulator; Reviewed; Region: PRK09559 1249634011013 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1249634011014 hemolysin; Provisional; Region: PRK15087 1249634011015 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1249634011016 HD domain; Region: HD_3; pfam13023 1249634011017 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634011018 metabolite-proton symporter; Region: 2A0106; TIGR00883 1249634011019 putative substrate translocation pore; other site 1249634011020 amidase; Provisional; Region: PRK07056 1249634011021 Amidase; Region: Amidase; cl11426 1249634011022 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 1249634011023 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1249634011024 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1249634011025 DNA-binding site [nucleotide binding]; DNA binding site 1249634011026 FCD domain; Region: FCD; pfam07729 1249634011027 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1249634011028 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1249634011029 Coenzyme A binding pocket [chemical binding]; other site 1249634011030 glycine dehydrogenase; Provisional; Region: PRK05367 1249634011031 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1249634011032 tetramer interface [polypeptide binding]; other site 1249634011033 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634011034 catalytic residue [active] 1249634011035 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1249634011036 tetramer interface [polypeptide binding]; other site 1249634011037 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634011038 catalytic residue [active] 1249634011039 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1249634011040 lipoyl attachment site [posttranslational modification]; other site 1249634011041 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1249634011042 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1249634011043 oxidoreductase; Provisional; Region: PRK08013 1249634011044 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1249634011045 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 1249634011046 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 1249634011047 proline aminopeptidase P II; Provisional; Region: PRK10879 1249634011048 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1249634011049 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1249634011050 active site 1249634011051 hypothetical protein; Reviewed; Region: PRK01736 1249634011052 Z-ring-associated protein; Provisional; Region: PRK10972 1249634011053 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1249634011054 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1249634011055 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1249634011056 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1249634011057 ligand binding site [chemical binding]; other site 1249634011058 NAD binding site [chemical binding]; other site 1249634011059 tetramer interface [polypeptide binding]; other site 1249634011060 catalytic site [active] 1249634011061 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1249634011062 L-serine binding site [chemical binding]; other site 1249634011063 ACT domain interface; other site 1249634011064 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1249634011065 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1249634011066 active site 1249634011067 dimer interface [polypeptide binding]; other site 1249634011068 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1249634011069 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634011070 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 1249634011071 putative dimerization interface [polypeptide binding]; other site 1249634011072 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1249634011073 oxidative stress defense protein; Provisional; Region: PRK11087 1249634011074 arginine exporter protein; Provisional; Region: PRK09304 1249634011075 mechanosensitive channel MscS; Provisional; Region: PRK10334 1249634011076 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1249634011077 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1249634011078 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 1249634011079 active site 1249634011080 intersubunit interface [polypeptide binding]; other site 1249634011081 zinc binding site [ion binding]; other site 1249634011082 Na+ binding site [ion binding]; other site 1249634011083 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1249634011084 Phosphoglycerate kinase; Region: PGK; pfam00162 1249634011085 substrate binding site [chemical binding]; other site 1249634011086 hinge regions; other site 1249634011087 ADP binding site [chemical binding]; other site 1249634011088 catalytic site [active] 1249634011089 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 1249634011090 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1249634011091 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1249634011092 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1249634011093 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 1249634011094 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1249634011095 catalytic core [active] 1249634011096 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1249634011097 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 1249634011098 transketolase; Reviewed; Region: PRK12753 1249634011099 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1249634011100 TPP-binding site [chemical binding]; other site 1249634011101 dimer interface [polypeptide binding]; other site 1249634011102 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1249634011103 PYR/PP interface [polypeptide binding]; other site 1249634011104 dimer interface [polypeptide binding]; other site 1249634011105 TPP binding site [chemical binding]; other site 1249634011106 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1249634011107 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1249634011108 hypothetical protein; Provisional; Region: PRK07064 1249634011109 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1249634011110 PYR/PP interface [polypeptide binding]; other site 1249634011111 dimer interface [polypeptide binding]; other site 1249634011112 TPP binding site [chemical binding]; other site 1249634011113 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1249634011114 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1249634011115 TPP-binding site [chemical binding]; other site 1249634011116 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1249634011117 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 1249634011118 NAD(P) binding site [chemical binding]; other site 1249634011119 catalytic residues [active] 1249634011120 L-aspartate dehydrogenase; Provisional; Region: PRK13303 1249634011121 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1249634011122 Domain of unknown function DUF108; Region: DUF108; pfam01958 1249634011123 short chain dehydrogenase; Provisional; Region: PRK07062 1249634011124 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1249634011125 putative NAD(P) binding site [chemical binding]; other site 1249634011126 putative active site [active] 1249634011127 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1249634011128 Cupin domain; Region: Cupin_2; pfam07883 1249634011129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634011130 D-galactonate transporter; Region: 2A0114; TIGR00893 1249634011131 putative substrate translocation pore; other site 1249634011132 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1249634011133 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1249634011134 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1249634011135 active site 1249634011136 metal binding site [ion binding]; metal-binding site 1249634011137 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 1249634011138 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1249634011139 putative active site [active] 1249634011140 putative metal binding site [ion binding]; other site 1249634011141 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1249634011142 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1249634011143 Bacterial transcriptional regulator; Region: IclR; pfam01614 1249634011144 short chain dehydrogenase; Provisional; Region: PRK12939 1249634011145 classical (c) SDRs; Region: SDR_c; cd05233 1249634011146 NAD(P) binding site [chemical binding]; other site 1249634011147 active site 1249634011148 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1249634011149 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1249634011150 [2Fe-2S] cluster binding site [ion binding]; other site 1249634011151 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1249634011152 hydrophobic ligand binding site; other site 1249634011153 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1249634011154 [2Fe-2S] cluster binding site [ion binding]; other site 1249634011155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634011156 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1249634011157 putative substrate translocation pore; other site 1249634011158 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 1249634011159 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1249634011160 RNA binding surface [nucleotide binding]; other site 1249634011161 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 1249634011162 probable active site [active] 1249634011163 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1249634011164 agmatinase; Region: agmatinase; TIGR01230 1249634011165 oligomer interface [polypeptide binding]; other site 1249634011166 putative active site [active] 1249634011167 Mn binding site [ion binding]; other site 1249634011168 arginine decarboxylase; Provisional; Region: PRK05354 1249634011169 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1249634011170 dimer interface [polypeptide binding]; other site 1249634011171 active site 1249634011172 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1249634011173 catalytic residues [active] 1249634011174 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1249634011175 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1249634011176 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1249634011177 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1249634011178 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1249634011179 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1249634011180 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1249634011181 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634011182 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634011183 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1249634011184 putative effector binding pocket; other site 1249634011185 dimerization interface [polypeptide binding]; other site 1249634011186 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1249634011187 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1249634011188 ABC-ATPase subunit interface; other site 1249634011189 dimer interface [polypeptide binding]; other site 1249634011190 putative PBP binding regions; other site 1249634011191 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1249634011192 ABC-ATPase subunit interface; other site 1249634011193 dimer interface [polypeptide binding]; other site 1249634011194 putative PBP binding regions; other site 1249634011195 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1249634011196 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1249634011197 intersubunit interface [polypeptide binding]; other site 1249634011198 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 1249634011199 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1249634011200 Walker A/P-loop; other site 1249634011201 ATP binding site [chemical binding]; other site 1249634011202 Q-loop/lid; other site 1249634011203 ABC transporter signature motif; other site 1249634011204 Walker B; other site 1249634011205 D-loop; other site 1249634011206 H-loop/switch region; other site 1249634011207 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1249634011208 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1249634011209 N-terminal plug; other site 1249634011210 ligand-binding site [chemical binding]; other site 1249634011211 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 1249634011212 Transglycosylase; Region: Transgly; pfam00912 1249634011213 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1249634011214 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 1249634011215 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1249634011216 ATP binding site [chemical binding]; other site 1249634011217 putative Mg++ binding site [ion binding]; other site 1249634011218 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1249634011219 nucleotide binding region [chemical binding]; other site 1249634011220 ATP-binding site [chemical binding]; other site 1249634011221 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1249634011222 2'-5' RNA ligase; Provisional; Region: PRK15124 1249634011223 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1249634011224 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1249634011225 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1249634011226 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 1249634011227 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1249634011228 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 1249634011229 active site 1249634011230 nucleotide binding site [chemical binding]; other site 1249634011231 HIGH motif; other site 1249634011232 KMSKS motif; other site 1249634011233 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 1249634011234 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1249634011235 active site 1249634011236 NTP binding site [chemical binding]; other site 1249634011237 metal binding triad [ion binding]; metal-binding site 1249634011238 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1249634011239 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1249634011240 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1249634011241 catalytic center binding site [active] 1249634011242 ATP binding site [chemical binding]; other site 1249634011243 sensor protein QseC; Provisional; Region: PRK10337 1249634011244 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1249634011245 dimer interface [polypeptide binding]; other site 1249634011246 phosphorylation site [posttranslational modification] 1249634011247 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1249634011248 ATP binding site [chemical binding]; other site 1249634011249 Mg2+ binding site [ion binding]; other site 1249634011250 G-X-G motif; other site 1249634011251 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 1249634011252 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634011253 active site 1249634011254 phosphorylation site [posttranslational modification] 1249634011255 intermolecular recognition site; other site 1249634011256 dimerization interface [polypeptide binding]; other site 1249634011257 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1249634011258 DNA binding site [nucleotide binding] 1249634011259 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1249634011260 oligomerization interface [polypeptide binding]; other site 1249634011261 active site 1249634011262 metal binding site [ion binding]; metal-binding site 1249634011263 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1249634011264 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1249634011265 active site 1249634011266 ATP-binding site [chemical binding]; other site 1249634011267 pantoate-binding site; other site 1249634011268 HXXH motif; other site 1249634011269 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1249634011270 tetramerization interface [polypeptide binding]; other site 1249634011271 active site 1249634011272 Bacterial SH3 domain; Region: SH3_3; cl17532 1249634011273 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 1249634011274 putative active site [active] 1249634011275 putative metal binding site [ion binding]; other site 1249634011276 inner membrane transport permease; Provisional; Region: PRK15066 1249634011277 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1249634011278 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1249634011279 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1249634011280 Walker A/P-loop; other site 1249634011281 ATP binding site [chemical binding]; other site 1249634011282 Q-loop/lid; other site 1249634011283 ABC transporter signature motif; other site 1249634011284 Walker B; other site 1249634011285 D-loop; other site 1249634011286 H-loop/switch region; other site 1249634011287 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1249634011288 active site clefts [active] 1249634011289 zinc binding site [ion binding]; other site 1249634011290 dimer interface [polypeptide binding]; other site 1249634011291 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1249634011292 active site 1249634011293 multicopper oxidase; Provisional; Region: PRK10965 1249634011294 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1249634011295 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 1249634011296 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1249634011297 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 1249634011298 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 1249634011299 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 1249634011300 spermidine synthase; Provisional; Region: PRK00811 1249634011301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1249634011302 S-adenosylmethionine binding site [chemical binding]; other site 1249634011303 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 1249634011304 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1249634011305 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1249634011306 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1249634011307 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1249634011308 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1249634011309 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1249634011310 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 1249634011311 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1249634011312 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 1249634011313 hypothetical protein; Provisional; Region: PRK05248 1249634011314 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634011315 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634011316 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1249634011317 dimerization interface [polypeptide binding]; other site 1249634011318 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1249634011319 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 1249634011320 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 1249634011321 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 1249634011322 Membrane transport protein; Region: Mem_trans; cl09117 1249634011323 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 1249634011324 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 1249634011325 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 1249634011326 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 1249634011327 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 1249634011328 Coenzyme A transferase; Region: CoA_trans; cl17247 1249634011329 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1249634011330 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1249634011331 substrate binding site [chemical binding]; other site 1249634011332 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1249634011333 substrate binding site [chemical binding]; other site 1249634011334 ligand binding site [chemical binding]; other site 1249634011335 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1249634011336 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1249634011337 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1249634011338 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1249634011339 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 1249634011340 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1249634011341 E3 interaction surface; other site 1249634011342 lipoyl attachment site [posttranslational modification]; other site 1249634011343 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1249634011344 E3 interaction surface; other site 1249634011345 lipoyl attachment site [posttranslational modification]; other site 1249634011346 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1249634011347 E3 interaction surface; other site 1249634011348 lipoyl attachment site [posttranslational modification]; other site 1249634011349 e3 binding domain; Region: E3_binding; pfam02817 1249634011350 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1249634011351 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1249634011352 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1249634011353 dimer interface [polypeptide binding]; other site 1249634011354 TPP-binding site [chemical binding]; other site 1249634011355 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 1249634011356 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1249634011357 DNA-binding site [nucleotide binding]; DNA binding site 1249634011358 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1249634011359 aromatic amino acid transporter; Provisional; Region: PRK10238 1249634011360 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1249634011361 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1249634011362 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1249634011363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634011364 putative substrate translocation pore; other site 1249634011365 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1249634011366 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634011367 putative substrate translocation pore; other site 1249634011368 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 1249634011369 active site 1249634011370 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1249634011371 Ligand binding site; other site 1249634011372 metal-binding site 1249634011373 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1249634011374 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1249634011375 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1249634011376 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1249634011377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634011378 putative substrate translocation pore; other site 1249634011379 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634011380 fumarate hydratase; Provisional; Region: PRK15389 1249634011381 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 1249634011382 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1249634011383 hypothetical protein; Provisional; Region: PRK04860 1249634011384 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1249634011385 DNA-specific endonuclease I; Provisional; Region: PRK15137 1249634011386 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 1249634011387 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1249634011388 RNA methyltransferase, RsmE family; Region: TIGR00046 1249634011389 glutathione synthetase; Provisional; Region: PRK05246 1249634011390 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1249634011391 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1249634011392 hypothetical protein; Validated; Region: PRK00228 1249634011393 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1249634011394 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1249634011395 PapC N-terminal domain; Region: PapC_N; pfam13954 1249634011396 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1249634011397 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 1249634011398 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1249634011399 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1249634011400 substrate binding pocket [chemical binding]; other site 1249634011401 membrane-bound complex binding site; other site 1249634011402 hinge residues; other site 1249634011403 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1249634011404 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1249634011405 substrate binding pocket [chemical binding]; other site 1249634011406 membrane-bound complex binding site; other site 1249634011407 hinge residues; other site 1249634011408 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1249634011409 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1249634011410 dimer interface [polypeptide binding]; other site 1249634011411 phosphorylation site [posttranslational modification] 1249634011412 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1249634011413 ATP binding site [chemical binding]; other site 1249634011414 Mg2+ binding site [ion binding]; other site 1249634011415 G-X-G motif; other site 1249634011416 Response regulator receiver domain; Region: Response_reg; pfam00072 1249634011417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634011418 active site 1249634011419 phosphorylation site [posttranslational modification] 1249634011420 intermolecular recognition site; other site 1249634011421 dimerization interface [polypeptide binding]; other site 1249634011422 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1249634011423 putative binding surface; other site 1249634011424 active site 1249634011425 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1249634011426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634011427 active site 1249634011428 phosphorylation site [posttranslational modification] 1249634011429 intermolecular recognition site; other site 1249634011430 dimerization interface [polypeptide binding]; other site 1249634011431 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1249634011432 DNA binding residues [nucleotide binding] 1249634011433 dimerization interface [polypeptide binding]; other site 1249634011434 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1249634011435 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1249634011436 Walker A motif; other site 1249634011437 ATP binding site [chemical binding]; other site 1249634011438 Walker B motif; other site 1249634011439 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 1249634011440 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1249634011441 catalytic residue [active] 1249634011442 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1249634011443 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1249634011444 YGGT family; Region: YGGT; pfam02325 1249634011445 YGGT family; Region: YGGT; pfam02325 1249634011446 hypothetical protein; Validated; Region: PRK05090 1249634011447 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1249634011448 active site 1249634011449 dimerization interface [polypeptide binding]; other site 1249634011450 HemN family oxidoreductase; Provisional; Region: PRK05660 1249634011451 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1249634011452 FeS/SAM binding site; other site 1249634011453 HemN C-terminal domain; Region: HemN_C; pfam06969 1249634011454 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 1249634011455 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 1249634011456 hypothetical protein; Provisional; Region: PRK10626 1249634011457 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 1249634011458 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1249634011459 glutaminase; Provisional; Region: PRK00971 1249634011460 hypothetical protein; Provisional; Region: PRK11702 1249634011461 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1249634011462 adenine DNA glycosylase; Provisional; Region: PRK10880 1249634011463 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1249634011464 minor groove reading motif; other site 1249634011465 helix-hairpin-helix signature motif; other site 1249634011466 substrate binding pocket [chemical binding]; other site 1249634011467 active site 1249634011468 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1249634011469 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1249634011470 DNA binding and oxoG recognition site [nucleotide binding] 1249634011471 oxidative damage protection protein; Provisional; Region: PRK05408 1249634011472 murein transglycosylase C; Provisional; Region: mltC; PRK11671 1249634011473 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 1249634011474 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1249634011475 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1249634011476 catalytic residue [active] 1249634011477 ornithine decarboxylase; Provisional; Region: PRK13578 1249634011478 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1249634011479 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1249634011480 homodimer interface [polypeptide binding]; other site 1249634011481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634011482 catalytic residue [active] 1249634011483 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1249634011484 outer membrane porin, OprD family; Region: OprD; pfam03573 1249634011485 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 1249634011486 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1249634011487 active site 1249634011488 metal binding site [ion binding]; metal-binding site 1249634011489 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1249634011490 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1249634011491 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1249634011492 Nucleoside recognition; Region: Gate; pfam07670 1249634011493 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1249634011494 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1249634011495 Isochorismatase family; Region: Isochorismatase; pfam00857 1249634011496 catalytic triad [active] 1249634011497 dimer interface [polypeptide binding]; other site 1249634011498 conserved cis-peptide bond; other site 1249634011499 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634011500 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634011501 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1249634011502 dimerization interface [polypeptide binding]; other site 1249634011503 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1249634011504 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1249634011505 PYR/PP interface [polypeptide binding]; other site 1249634011506 dimer interface [polypeptide binding]; other site 1249634011507 TPP binding site [chemical binding]; other site 1249634011508 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1249634011509 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1249634011510 TPP-binding site [chemical binding]; other site 1249634011511 dimer interface [polypeptide binding]; other site 1249634011512 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634011513 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1249634011514 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1249634011515 dimerization interface [polypeptide binding]; other site 1249634011516 substrate binding pocket [chemical binding]; other site 1249634011517 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1249634011518 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1249634011519 conserved cys residue [active] 1249634011520 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634011521 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1249634011522 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 1249634011523 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1249634011524 acyl-activating enzyme (AAE) consensus motif; other site 1249634011525 acyl-activating enzyme (AAE) consensus motif; other site 1249634011526 active site 1249634011527 AMP binding site [chemical binding]; other site 1249634011528 CoA binding site [chemical binding]; other site 1249634011529 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1249634011530 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1249634011531 NAD(P) binding site [chemical binding]; other site 1249634011532 active site 1249634011533 Pseudomonas avirulence D protein (AvrD); Region: AvrD; pfam05655 1249634011534 AAA domain; Region: AAA_28; pfam13521 1249634011535 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1249634011536 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1249634011537 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634011538 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1249634011539 putative substrate translocation pore; other site 1249634011540 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1249634011541 NAD(P) binding site [chemical binding]; other site 1249634011542 active site 1249634011543 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1249634011544 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1249634011545 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1249634011546 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1249634011547 substrate binding pocket [chemical binding]; other site 1249634011548 membrane-bound complex binding site; other site 1249634011549 hinge residues; other site 1249634011550 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1249634011551 active site residue [active] 1249634011552 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 1249634011553 active site residue [active] 1249634011554 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 1249634011555 active site residue [active] 1249634011556 Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535 1249634011557 active site residue [active] 1249634011558 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 1249634011559 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634011560 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634011561 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1249634011562 dimerization interface [polypeptide binding]; other site 1249634011563 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1249634011564 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1249634011565 dimer interface [polypeptide binding]; other site 1249634011566 active site 1249634011567 non-prolyl cis peptide bond; other site 1249634011568 insertion regions; other site 1249634011569 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1249634011570 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1249634011571 active site 1249634011572 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1249634011573 membrane-bound complex binding site; other site 1249634011574 hinge residues; other site 1249634011575 NMT1-like family; Region: NMT1_2; pfam13379 1249634011576 NMT1/THI5 like; Region: NMT1; pfam09084 1249634011577 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1249634011578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634011579 dimer interface [polypeptide binding]; other site 1249634011580 conserved gate region; other site 1249634011581 putative PBP binding loops; other site 1249634011582 ABC-ATPase subunit interface; other site 1249634011583 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1249634011584 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1249634011585 Walker A/P-loop; other site 1249634011586 ATP binding site [chemical binding]; other site 1249634011587 Q-loop/lid; other site 1249634011588 ABC transporter signature motif; other site 1249634011589 Walker B; other site 1249634011590 D-loop; other site 1249634011591 H-loop/switch region; other site 1249634011592 aldolase II superfamily protein; Provisional; Region: PRK07044 1249634011593 active site 1249634011594 intersubunit interface [polypeptide binding]; other site 1249634011595 Zn2+ binding site [ion binding]; other site 1249634011596 Protein of unknown function (DUF796); Region: DUF796; pfam05638 1249634011597 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1249634011598 bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108 1249634011599 Moco binding site; other site 1249634011600 metal coordination site [ion binding]; other site 1249634011601 Prokaryotic cytochrome b561; Region: Ni_hydr_CYTB; pfam01292 1249634011602 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 1249634011603 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1249634011604 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1249634011605 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1249634011606 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1249634011607 DNA binding residues [nucleotide binding] 1249634011608 dimerization interface [polypeptide binding]; other site 1249634011609 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634011610 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634011611 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1249634011612 dimerization interface [polypeptide binding]; other site 1249634011613 Enterobacteria AfaD invasin protein; Region: AfaD; cl05376 1249634011614 pilin outer membrane usher protein SafC; Provisional; Region: PRK15223 1249634011615 PapC N-terminal domain; Region: PapC_N; pfam13954 1249634011616 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1249634011617 PapC C-terminal domain; Region: PapC_C; pfam13953 1249634011618 pili assembly chaperone protein SafB; Provisional; Region: PRK15224 1249634011619 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1249634011620 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1249634011621 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1249634011622 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 1249634011623 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1249634011624 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 1249634011625 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1249634011626 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1249634011627 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1249634011628 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 1249634011629 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 1249634011630 Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156 1249634011631 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1249634011632 type II secretion system protein J; Region: gspJ; TIGR01711 1249634011633 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 1249634011634 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1249634011635 type II secretion system protein I; Region: gspI; TIGR01707 1249634011636 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 1249634011637 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1249634011638 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1249634011639 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1249634011640 type II secretion system protein F; Region: GspF; TIGR02120 1249634011641 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1249634011642 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1249634011643 type II secretion system protein E; Region: type_II_gspE; TIGR02533 1249634011644 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1249634011645 Walker A motif; other site 1249634011646 ATP binding site [chemical binding]; other site 1249634011647 Walker B motif; other site 1249634011648 type II secretion system protein D; Region: type_II_gspD; TIGR02517 1249634011649 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1249634011650 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1249634011651 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1249634011652 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1249634011653 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 1249634011654 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1249634011655 DNA binding site [nucleotide binding] 1249634011656 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1249634011657 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1249634011658 catalytic residues [active] 1249634011659 hinge region; other site 1249634011660 alpha helical domain; other site 1249634011661 putative transposase OrfB; Reviewed; Region: PHA02517 1249634011662 Integrase core domain; Region: rve; pfam00665 1249634011663 Integrase core domain; Region: rve_2; pfam13333 1249634011664 Transposase; Region: HTH_Tnp_1; cl17663 1249634011665 PAS domain; Region: PAS; smart00091 1249634011666 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1249634011667 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1249634011668 dimer interface [polypeptide binding]; other site 1249634011669 phosphorylation site [posttranslational modification] 1249634011670 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1249634011671 ATP binding site [chemical binding]; other site 1249634011672 Mg2+ binding site [ion binding]; other site 1249634011673 G-X-G motif; other site 1249634011674 Response regulator receiver domain; Region: Response_reg; pfam00072 1249634011675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634011676 active site 1249634011677 phosphorylation site [posttranslational modification] 1249634011678 intermolecular recognition site; other site 1249634011679 dimerization interface [polypeptide binding]; other site 1249634011680 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1249634011681 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634011682 active site 1249634011683 phosphorylation site [posttranslational modification] 1249634011684 intermolecular recognition site; other site 1249634011685 dimerization interface [polypeptide binding]; other site 1249634011686 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1249634011687 DNA binding residues [nucleotide binding] 1249634011688 dimerization interface [polypeptide binding]; other site 1249634011689 MASE1; Region: MASE1; cl17823 1249634011690 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 1249634011691 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1249634011692 beta-galactosidase; Region: BGL; TIGR03356 1249634011693 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 1249634011694 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1249634011695 active site turn [active] 1249634011696 phosphorylation site [posttranslational modification] 1249634011697 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl17885 1249634011698 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1249634011699 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1249634011700 DNA binding site [nucleotide binding] 1249634011701 domain linker motif; other site 1249634011702 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1249634011703 Predicted transcriptional regulator [Transcription]; Region: COG1959 1249634011704 Transcriptional regulator; Region: Rrf2; pfam02082 1249634011705 Transcriptional regulator; Region: Rrf2; cl17282 1249634011706 putative transporter; Provisional; Region: PRK10504 1249634011707 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634011708 putative substrate translocation pore; other site 1249634011709 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1249634011710 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1249634011711 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634011712 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634011713 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1249634011714 putative effector binding pocket; other site 1249634011715 putative dimerization interface [polypeptide binding]; other site 1249634011716 short chain dehydrogenase; Provisional; Region: PRK12937 1249634011717 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1249634011718 NADP binding site [chemical binding]; other site 1249634011719 homodimer interface [polypeptide binding]; other site 1249634011720 active site 1249634011721 substrate binding site [chemical binding]; other site 1249634011722 citrate-proton symporter; Provisional; Region: PRK15075 1249634011723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634011724 putative substrate translocation pore; other site 1249634011725 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1249634011726 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1249634011727 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634011728 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634011729 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1249634011730 putative dimerization interface [polypeptide binding]; other site 1249634011731 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 1249634011732 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1249634011733 non-specific DNA binding site [nucleotide binding]; other site 1249634011734 salt bridge; other site 1249634011735 sequence-specific DNA binding site [nucleotide binding]; other site 1249634011736 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1249634011737 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1249634011738 TM-ABC transporter signature motif; other site 1249634011739 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1249634011740 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1249634011741 Walker A/P-loop; other site 1249634011742 ATP binding site [chemical binding]; other site 1249634011743 Q-loop/lid; other site 1249634011744 ABC transporter signature motif; other site 1249634011745 Walker B; other site 1249634011746 D-loop; other site 1249634011747 H-loop/switch region; other site 1249634011748 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1249634011749 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; cl02395 1249634011750 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1249634011751 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1249634011752 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1249634011753 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1249634011754 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1249634011755 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1249634011756 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1249634011757 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1249634011758 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1249634011759 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1249634011760 PYR/PP interface [polypeptide binding]; other site 1249634011761 dimer interface [polypeptide binding]; other site 1249634011762 TPP binding site [chemical binding]; other site 1249634011763 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1249634011764 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1249634011765 TPP-binding site [chemical binding]; other site 1249634011766 dimer interface [polypeptide binding]; other site 1249634011767 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1249634011768 MarR family; Region: MarR_2; pfam12802 1249634011769 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1249634011770 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 1249634011771 bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791 1249634011772 N- and C-terminal domain interface [polypeptide binding]; other site 1249634011773 active site 1249634011774 MgATP binding site [chemical binding]; other site 1249634011775 catalytic site [active] 1249634011776 metal binding site [ion binding]; metal-binding site 1249634011777 putative homotetramer interface [polypeptide binding]; other site 1249634011778 putative homodimer interface [polypeptide binding]; other site 1249634011779 glycerol binding site [chemical binding]; other site 1249634011780 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1249634011781 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1249634011782 NAD(P) binding site [chemical binding]; other site 1249634011783 active site 1249634011784 polyol permease family; Region: 2A0118; TIGR00897 1249634011785 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634011786 putative substrate translocation pore; other site 1249634011787 short chain dehydrogenase; Provisional; Region: PRK06114 1249634011788 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1249634011789 NAD(P) binding site [chemical binding]; other site 1249634011790 active site 1249634011791 Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048 1249634011792 hypothetical protein; Provisional; Region: PRK05409 1249634011793 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 1249634011794 Putative zinc-finger; Region: zf-HC2; pfam13490 1249634011795 RNA polymerase sigma factor; Provisional; Region: PRK12544 1249634011796 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1249634011797 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1249634011798 proline/glycine betaine transporter; Provisional; Region: PRK10642 1249634011799 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634011800 putative substrate translocation pore; other site 1249634011801 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1249634011802 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1249634011803 dimerization interface [polypeptide binding]; other site 1249634011804 DNA binding residues [nucleotide binding] 1249634011805 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1249634011806 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1249634011807 NAD(P) binding site [chemical binding]; other site 1249634011808 active site 1249634011809 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1249634011810 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634011811 putative substrate translocation pore; other site 1249634011812 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 1249634011813 aminoglycoside resistance protein; Provisional; Region: PRK13746 1249634011814 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1249634011815 active site 1249634011816 NTP binding site [chemical binding]; other site 1249634011817 metal binding triad [ion binding]; metal-binding site 1249634011818 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 1249634011819 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1249634011820 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1249634011821 DNA-binding site [nucleotide binding]; DNA binding site 1249634011822 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1249634011823 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634011824 homodimer interface [polypeptide binding]; other site 1249634011825 catalytic residue [active] 1249634011826 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1249634011827 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1249634011828 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1249634011829 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1249634011830 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1249634011831 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 1249634011832 NADP binding site [chemical binding]; other site 1249634011833 dimer interface [polypeptide binding]; other site 1249634011834 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 1249634011835 putative transporter; Provisional; Region: PRK11660 1249634011836 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1249634011837 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1249634011838 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1249634011839 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1249634011840 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1249634011841 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1249634011842 hypothetical protein; Provisional; Region: PRK10220 1249634011843 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1249634011844 PhnA protein; Region: PhnA; pfam03831 1249634011845 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1249634011846 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1249634011847 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; cl07929 1249634011848 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1249634011849 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1249634011850 inhibitor-cofactor binding pocket; inhibition site 1249634011851 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634011852 catalytic residue [active] 1249634011853 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1249634011854 active site 1249634011855 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1249634011856 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1249634011857 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1249634011858 catalytic residue [active] 1249634011859 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1249634011860 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1249634011861 Walker A motif; other site 1249634011862 ATP binding site [chemical binding]; other site 1249634011863 Walker B motif; other site 1249634011864 arginine finger; other site 1249634011865 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1249634011866 Type III secretion needle MxiH like; Region: MxiH; cl09641 1249634011867 type III secretion apparatus lipoprotein, YscJ/HrcJ family; Region: III_secr_YscJ; TIGR02544 1249634011868 HrpE/YscL/FliH and V-type ATPase subunit E; Region: HrpE; pfam06188 1249634011869 HrpF protein; Region: HrpF; pfam06266 1249634011870 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 1249634011871 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1249634011872 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1249634011873 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1249634011874 Pathogenicity factor; Region: AvrE; pfam11725 1249634011875 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 1249634011876 type III secretion protein, YscU/HrpY family; Region: FlhB_rel_III; TIGR01404 1249634011877 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1249634011878 Bacterial export proteins, family 1; Region: Bac_export_1; pfam01311 1249634011879 type III secretion protein, HrpO family; Region: fliQ_rel_III; TIGR01403 1249634011880 type III secretion system protein YscR; Provisional; Region: PRK12797 1249634011881 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 1249634011882 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1249634011883 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 1249634011884 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1249634011885 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1249634011886 Walker A motif; other site 1249634011887 ATP binding site [chemical binding]; other site 1249634011888 Walker B motif; other site 1249634011889 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 1249634011890 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 1249634011891 type III secretion protein, HrcV family; Region: hrcV; TIGR01399 1249634011892 FHIPEP family; Region: FHIPEP; pfam00771 1249634011893 HrpJ-like domain; Region: HrpJ; pfam07201 1249634011894 TyeA; Region: TyeA; cl07611 1249634011895 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1249634011896 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1249634011897 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1249634011898 DNA binding residues [nucleotide binding] 1249634011899 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1249634011900 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1249634011901 putative active site [active] 1249634011902 heme pocket [chemical binding]; other site 1249634011903 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1249634011904 putative active site [active] 1249634011905 heme pocket [chemical binding]; other site 1249634011906 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1249634011907 Histidine kinase; Region: HisKA_3; pfam07730 1249634011908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1249634011909 ATP binding site [chemical binding]; other site 1249634011910 Mg2+ binding site [ion binding]; other site 1249634011911 G-X-G motif; other site 1249634011912 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1249634011913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634011914 active site 1249634011915 phosphorylation site [posttranslational modification] 1249634011916 intermolecular recognition site; other site 1249634011917 dimerization interface [polypeptide binding]; other site 1249634011918 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1249634011919 DNA binding residues [nucleotide binding] 1249634011920 dimerization interface [polypeptide binding]; other site 1249634011921 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1249634011922 metal-binding site [ion binding] 1249634011923 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1249634011924 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1249634011925 metal-binding site [ion binding] 1249634011926 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1249634011927 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1249634011928 motif II; other site 1249634011929 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1249634011930 putative catalytic site [active] 1249634011931 putative metal binding site [ion binding]; other site 1249634011932 putative phosphate binding site [ion binding]; other site 1249634011933 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634011934 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634011935 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1249634011936 putative effector binding pocket; other site 1249634011937 putative dimerization interface [polypeptide binding]; other site 1249634011938 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 1249634011939 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1249634011940 putative NAD(P) binding site [chemical binding]; other site 1249634011941 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1249634011942 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1249634011943 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1249634011944 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1249634011945 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 1249634011946 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 1249634011947 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1249634011948 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1249634011949 HSP70 interaction site [polypeptide binding]; other site 1249634011950 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1249634011951 substrate binding site [polypeptide binding]; other site 1249634011952 dimer interface [polypeptide binding]; other site 1249634011953 acid-resistance membrane protein; Provisional; Region: PRK10209 1249634011954 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1249634011955 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1249634011956 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1249634011957 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1249634011958 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1249634011959 E3 interaction surface; other site 1249634011960 lipoyl attachment site [posttranslational modification]; other site 1249634011961 HlyD family secretion protein; Region: HlyD_3; pfam13437 1249634011962 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1249634011963 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 1249634011964 putative active site [active] 1249634011965 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1249634011966 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1249634011967 Walker A/P-loop; other site 1249634011968 ATP binding site [chemical binding]; other site 1249634011969 Q-loop/lid; other site 1249634011970 ABC transporter signature motif; other site 1249634011971 Walker B; other site 1249634011972 D-loop; other site 1249634011973 H-loop/switch region; other site 1249634011974 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 1249634011975 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1249634011976 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1249634011977 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1249634011978 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1249634011979 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1249634011980 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1249634011981 putative substrate binding site [chemical binding]; other site 1249634011982 putative ATP binding site [chemical binding]; other site 1249634011983 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 1249634011984 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1249634011985 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1249634011986 active site turn [active] 1249634011987 phosphorylation site [posttranslational modification] 1249634011988 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1249634011989 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1249634011990 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1249634011991 substrate binding [chemical binding]; other site 1249634011992 active site 1249634011993 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1249634011994 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 1249634011995 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1249634011996 DNA binding site [nucleotide binding] 1249634011997 domain linker motif; other site 1249634011998 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1249634011999 dimerization interface [polypeptide binding]; other site 1249634012000 ligand binding site [chemical binding]; other site 1249634012001 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 1249634012002 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1249634012003 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1249634012004 shikimate binding site; other site 1249634012005 NAD(P) binding site [chemical binding]; other site 1249634012006 biopolymer transport protein ExbD; Provisional; Region: PRK11267 1249634012007 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1249634012008 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1249634012009 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1249634012010 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1249634012011 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1249634012012 DctM-like transporters; Region: DctM; pfam06808 1249634012013 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1249634012014 cystathionine beta-lyase; Provisional; Region: PRK08114 1249634012015 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1249634012016 homodimer interface [polypeptide binding]; other site 1249634012017 substrate-cofactor binding pocket; other site 1249634012018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634012019 catalytic residue [active] 1249634012020 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1249634012021 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1249634012022 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1249634012023 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1249634012024 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634012025 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634012026 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1249634012027 dimer interface [polypeptide binding]; other site 1249634012028 FMN binding site [chemical binding]; other site 1249634012029 NADPH bind site [chemical binding]; other site 1249634012030 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1249634012031 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1249634012032 dimer interface [polypeptide binding]; other site 1249634012033 active site 1249634012034 metal binding site [ion binding]; metal-binding site 1249634012035 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1249634012036 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1249634012037 active site 1249634012038 catalytic tetrad [active] 1249634012039 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 1249634012040 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1249634012041 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1249634012042 catalytic residue [active] 1249634012043 hypothetical protein; Provisional; Region: PRK01254 1249634012044 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 1249634012045 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 1249634012046 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1249634012047 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1249634012048 DNA-binding site [nucleotide binding]; DNA binding site 1249634012049 UTRA domain; Region: UTRA; pfam07702 1249634012050 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 1249634012051 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1249634012052 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1249634012053 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1249634012054 substrate binding site [chemical binding]; other site 1249634012055 ATP binding site [chemical binding]; other site 1249634012056 FtsI repressor; Provisional; Region: PRK10883 1249634012057 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1249634012058 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1249634012059 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 1249634012060 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1249634012061 putative acyl-acceptor binding pocket; other site 1249634012062 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1249634012063 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1249634012064 CAP-like domain; other site 1249634012065 active site 1249634012066 primary dimer interface [polypeptide binding]; other site 1249634012067 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1249634012068 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1249634012069 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1249634012070 sequence-specific DNA binding site [nucleotide binding]; other site 1249634012071 salt bridge; other site 1249634012072 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1249634012073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1249634012074 ATP binding site [chemical binding]; other site 1249634012075 Mg2+ binding site [ion binding]; other site 1249634012076 G-X-G motif; other site 1249634012077 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1249634012078 anchoring element; other site 1249634012079 dimer interface [polypeptide binding]; other site 1249634012080 ATP binding site [chemical binding]; other site 1249634012081 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1249634012082 active site 1249634012083 metal binding site [ion binding]; metal-binding site 1249634012084 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1249634012085 esterase YqiA; Provisional; Region: PRK11071 1249634012086 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1249634012087 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1249634012088 active site 1249634012089 metal binding site [ion binding]; metal-binding site 1249634012090 hexamer interface [polypeptide binding]; other site 1249634012091 putative dehydrogenase; Provisional; Region: PRK11039 1249634012092 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1249634012093 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1249634012094 dimer interface [polypeptide binding]; other site 1249634012095 ADP-ribose binding site [chemical binding]; other site 1249634012096 active site 1249634012097 nudix motif; other site 1249634012098 metal binding site [ion binding]; metal-binding site 1249634012099 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 1249634012100 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 1249634012101 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1249634012102 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1249634012103 dimerization domain swap beta strand [polypeptide binding]; other site 1249634012104 regulatory protein interface [polypeptide binding]; other site 1249634012105 active site 1249634012106 regulatory phosphorylation site [posttranslational modification]; other site 1249634012107 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1249634012108 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1249634012109 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 1249634012110 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 1249634012111 Dak1 domain; Region: Dak1; pfam02733 1249634012112 hypothetical protein; Provisional; Region: PRK11653 1249634012113 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1249634012114 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1249634012115 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1249634012116 putative active site [active] 1249634012117 metal binding site [ion binding]; metal-binding site 1249634012118 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 1249634012119 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 1249634012120 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1249634012121 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 1249634012122 putative transporter; Provisional; Region: PRK11021 1249634012123 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 1249634012124 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1249634012125 putative ribose interaction site [chemical binding]; other site 1249634012126 putative ADP binding site [chemical binding]; other site 1249634012127 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1249634012128 active site 1249634012129 nucleotide binding site [chemical binding]; other site 1249634012130 HIGH motif; other site 1249634012131 KMSKS motif; other site 1249634012132 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1249634012133 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1249634012134 metal binding triad; other site 1249634012135 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1249634012136 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1249634012137 metal binding triad; other site 1249634012138 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1249634012139 Uncharacterized conserved protein [Function unknown]; Region: COG3025 1249634012140 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1249634012141 putative active site [active] 1249634012142 putative metal binding residues [ion binding]; other site 1249634012143 signature motif; other site 1249634012144 putative triphosphate binding site [ion binding]; other site 1249634012145 SH3 domain-containing protein; Provisional; Region: PRK10884 1249634012146 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1249634012147 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1249634012148 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1249634012149 active site 1249634012150 NTP binding site [chemical binding]; other site 1249634012151 metal binding triad [ion binding]; metal-binding site 1249634012152 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1249634012153 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1249634012154 Zn2+ binding site [ion binding]; other site 1249634012155 Mg2+ binding site [ion binding]; other site 1249634012156 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1249634012157 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1249634012158 homooctamer interface [polypeptide binding]; other site 1249634012159 active site 1249634012160 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1249634012161 UGMP family protein; Validated; Region: PRK09604 1249634012162 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1249634012163 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1249634012164 DNA primase; Validated; Region: dnaG; PRK05667 1249634012165 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1249634012166 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1249634012167 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1249634012168 active site 1249634012169 metal binding site [ion binding]; metal-binding site 1249634012170 interdomain interaction site; other site 1249634012171 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1249634012172 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 1249634012173 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1249634012174 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1249634012175 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1249634012176 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1249634012177 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1249634012178 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1249634012179 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1249634012180 DNA binding residues [nucleotide binding] 1249634012181 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1249634012182 active site 1249634012183 SUMO-1 interface [polypeptide binding]; other site 1249634012184 alanine racemase; Reviewed; Region: PRK13340 1249634012185 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme, Alanine Racemase 2; Region: PLPDE_III_AR2; cd06826 1249634012186 active site 1249634012187 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1249634012188 dimer interface [polypeptide binding]; other site 1249634012189 substrate binding site [chemical binding]; other site 1249634012190 catalytic residues [active] 1249634012191 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1249634012192 RHS Repeat; Region: RHS_repeat; pfam05593 1249634012193 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1249634012194 RHS Repeat; Region: RHS_repeat; pfam05593 1249634012195 RHS Repeat; Region: RHS_repeat; pfam05593 1249634012196 RHS Repeat; Region: RHS_repeat; cl11982 1249634012197 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1249634012198 RHS Repeat; Region: RHS_repeat; cl11982 1249634012199 RHS Repeat; Region: RHS_repeat; pfam05593 1249634012200 RHS protein; Region: RHS; pfam03527 1249634012201 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1249634012202 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1249634012203 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1249634012204 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1249634012205 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 1249634012206 glutathione S-transferase; Provisional; Region: PRK15113 1249634012207 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1249634012208 C-terminal domain interface [polypeptide binding]; other site 1249634012209 GSH binding site (G-site) [chemical binding]; other site 1249634012210 dimer interface [polypeptide binding]; other site 1249634012211 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 1249634012212 N-terminal domain interface [polypeptide binding]; other site 1249634012213 putative dimer interface [polypeptide binding]; other site 1249634012214 putative substrate binding pocket (H-site) [chemical binding]; other site 1249634012215 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1249634012216 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1249634012217 succinic semialdehyde dehydrogenase; Region: PLN02278 1249634012218 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1249634012219 tetramerization interface [polypeptide binding]; other site 1249634012220 NAD(P) binding site [chemical binding]; other site 1249634012221 catalytic residues [active] 1249634012222 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 1249634012223 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1249634012224 inhibitor-cofactor binding pocket; inhibition site 1249634012225 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634012226 catalytic residue [active] 1249634012227 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1249634012228 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1249634012229 DNA-binding site [nucleotide binding]; DNA binding site 1249634012230 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1249634012231 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634012232 homodimer interface [polypeptide binding]; other site 1249634012233 catalytic residue [active] 1249634012234 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1249634012235 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1249634012236 Walker A/P-loop; other site 1249634012237 ATP binding site [chemical binding]; other site 1249634012238 Q-loop/lid; other site 1249634012239 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1249634012240 ABC transporter signature motif; other site 1249634012241 Walker B; other site 1249634012242 D-loop; other site 1249634012243 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1249634012244 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1249634012245 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1249634012246 active site 1249634012247 FMN binding site [chemical binding]; other site 1249634012248 2,4-decadienoyl-CoA binding site; other site 1249634012249 catalytic residue [active] 1249634012250 4Fe-4S cluster binding site [ion binding]; other site 1249634012251 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1249634012252 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1249634012253 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 1249634012254 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1249634012255 S-adenosylmethionine binding site [chemical binding]; other site 1249634012256 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 1249634012257 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1249634012258 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1249634012259 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1249634012260 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1249634012261 catalytic triad [active] 1249634012262 yybP-ykoY leader; D781_4042; IMG reference gene:2517285432 1249634012263 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1249634012264 serine/threonine transporter SstT; Provisional; Region: PRK13628 1249634012265 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1249634012266 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1249634012267 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1249634012268 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1249634012269 Glucuronate isomerase; Region: UxaC; pfam02614 1249634012270 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1249634012271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634012272 D-galactonate transporter; Region: 2A0114; TIGR00893 1249634012273 putative substrate translocation pore; other site 1249634012274 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 1249634012275 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1249634012276 DNA-binding site [nucleotide binding]; DNA binding site 1249634012277 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1249634012278 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1249634012279 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1249634012280 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 1249634012281 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 1249634012282 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 1249634012283 Predicted membrane protein [Function unknown]; Region: COG5393 1249634012284 YqjK-like protein; Region: YqjK; pfam13997 1249634012285 Predicted membrane protein [Function unknown]; Region: COG2259 1249634012286 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1249634012287 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1249634012288 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1249634012289 putative dimer interface [polypeptide binding]; other site 1249634012290 N-terminal domain interface [polypeptide binding]; other site 1249634012291 putative substrate binding pocket (H-site) [chemical binding]; other site 1249634012292 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634012293 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1249634012294 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1249634012295 dimerization interface [polypeptide binding]; other site 1249634012296 Pirin-related protein [General function prediction only]; Region: COG1741 1249634012297 Pirin; Region: Pirin; pfam02678 1249634012298 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1249634012299 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1249634012300 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 1249634012301 SnoaL-like domain; Region: SnoaL_2; pfam12680 1249634012302 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1249634012303 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1249634012304 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1249634012305 [4Fe-4S] binding site [ion binding]; other site 1249634012306 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1249634012307 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1249634012308 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1249634012309 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1249634012310 molybdopterin cofactor binding site; other site 1249634012311 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1249634012312 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1249634012313 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 1249634012314 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 1249634012315 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1249634012316 putative SAM binding site [chemical binding]; other site 1249634012317 putative homodimer interface [polypeptide binding]; other site 1249634012318 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1249634012319 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1249634012320 putative ligand binding site [chemical binding]; other site 1249634012321 hypothetical protein; Reviewed; Region: PRK12497 1249634012322 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1249634012323 dimer interface [polypeptide binding]; other site 1249634012324 active site 1249634012325 outer membrane lipoprotein; Provisional; Region: PRK11023 1249634012326 BON domain; Region: BON; pfam04972 1249634012327 BON domain; Region: BON; pfam04972 1249634012328 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1249634012329 Transglycosylase; Region: Transgly; cl17702 1249634012330 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 1249634012331 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 1249634012332 conserved cys residue [active] 1249634012333 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 1249634012334 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1249634012335 putative active site [active] 1249634012336 heme pocket [chemical binding]; other site 1249634012337 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1249634012338 dimer interface [polypeptide binding]; other site 1249634012339 phosphorylation site [posttranslational modification] 1249634012340 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1249634012341 ATP binding site [chemical binding]; other site 1249634012342 Mg2+ binding site [ion binding]; other site 1249634012343 G-X-G motif; other site 1249634012344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634012345 active site 1249634012346 phosphorylation site [posttranslational modification] 1249634012347 intermolecular recognition site; other site 1249634012348 dimerization interface [polypeptide binding]; other site 1249634012349 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1249634012350 putative binding surface; other site 1249634012351 active site 1249634012352 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1249634012353 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1249634012354 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1249634012355 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1249634012356 active site 1249634012357 dimer interface [polypeptide binding]; other site 1249634012358 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1249634012359 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1249634012360 active site 1249634012361 FMN binding site [chemical binding]; other site 1249634012362 substrate binding site [chemical binding]; other site 1249634012363 3Fe-4S cluster binding site [ion binding]; other site 1249634012364 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1249634012365 domain interface; other site 1249634012366 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 1249634012367 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1249634012368 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1249634012369 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1249634012370 N-acetylmannosamine kinase; Provisional; Region: PRK05082 1249634012371 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1249634012372 nucleotide binding site [chemical binding]; other site 1249634012373 putative sialic acid transporter; Provisional; Region: PRK03893 1249634012374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634012375 putative substrate translocation pore; other site 1249634012376 N-acetylneuraminate lyase; Provisional; Region: PRK04147 1249634012377 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 1249634012378 inhibitor site; inhibition site 1249634012379 active site 1249634012380 dimer interface [polypeptide binding]; other site 1249634012381 catalytic residue [active] 1249634012382 transcriptional regulator NanR; Provisional; Region: PRK03837 1249634012383 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1249634012384 DNA-binding site [nucleotide binding]; DNA binding site 1249634012385 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1249634012386 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 1249634012387 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1249634012388 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 1249634012389 C-terminal domain interface [polypeptide binding]; other site 1249634012390 putative GSH binding site (G-site) [chemical binding]; other site 1249634012391 dimer interface [polypeptide binding]; other site 1249634012392 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1249634012393 dimer interface [polypeptide binding]; other site 1249634012394 N-terminal domain interface [polypeptide binding]; other site 1249634012395 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1249634012396 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1249634012397 23S rRNA interface [nucleotide binding]; other site 1249634012398 L3 interface [polypeptide binding]; other site 1249634012399 Predicted ATPase [General function prediction only]; Region: COG1485 1249634012400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 1249634012401 hypothetical protein; Provisional; Region: PRK11677 1249634012402 serine endoprotease; Provisional; Region: PRK10139 1249634012403 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1249634012404 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1249634012405 protein binding site [polypeptide binding]; other site 1249634012406 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1249634012407 serine endoprotease; Provisional; Region: PRK10898 1249634012408 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1249634012409 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1249634012410 protein binding site [polypeptide binding]; other site 1249634012411 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1249634012412 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1249634012413 hinge; other site 1249634012414 active site 1249634012415 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 1249634012416 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1249634012417 anti sigma factor interaction site; other site 1249634012418 regulatory phosphorylation site [posttranslational modification]; other site 1249634012419 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 1249634012420 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1249634012421 mce related protein; Region: MCE; pfam02470 1249634012422 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1249634012423 conserved hypothetical integral membrane protein; Region: TIGR00056 1249634012424 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 1249634012425 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1249634012426 Walker A/P-loop; other site 1249634012427 ATP binding site [chemical binding]; other site 1249634012428 Q-loop/lid; other site 1249634012429 ABC transporter signature motif; other site 1249634012430 Walker B; other site 1249634012431 D-loop; other site 1249634012432 H-loop/switch region; other site 1249634012433 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 1249634012434 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1249634012435 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1249634012436 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1249634012437 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1249634012438 putative active site [active] 1249634012439 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1249634012440 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 1249634012441 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1249634012442 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 1249634012443 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1249634012444 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 1249634012445 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1249634012446 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 1249634012447 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1249634012448 Walker A/P-loop; other site 1249634012449 ATP binding site [chemical binding]; other site 1249634012450 Q-loop/lid; other site 1249634012451 ABC transporter signature motif; other site 1249634012452 Walker B; other site 1249634012453 D-loop; other site 1249634012454 H-loop/switch region; other site 1249634012455 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1249634012456 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1249634012457 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1249634012458 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1249634012459 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1249634012460 30S subunit binding site; other site 1249634012461 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1249634012462 active site 1249634012463 phosphorylation site [posttranslational modification] 1249634012464 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 1249634012465 AAA domain; Region: AAA_18; pfam13238 1249634012466 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1249634012467 dimerization domain swap beta strand [polypeptide binding]; other site 1249634012468 regulatory protein interface [polypeptide binding]; other site 1249634012469 active site 1249634012470 regulatory phosphorylation site [posttranslational modification]; other site 1249634012471 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1249634012472 HTH domain; Region: HTH_11; pfam08279 1249634012473 Mga helix-turn-helix domain; Region: Mga; pfam05043 1249634012474 PRD domain; Region: PRD; pfam00874 1249634012475 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1249634012476 active site 1249634012477 P-loop; other site 1249634012478 phosphorylation site [posttranslational modification] 1249634012479 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1249634012480 active site 1249634012481 phosphorylation site [posttranslational modification] 1249634012482 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1249634012483 Protein of unknown function (DUF1341); Region: DUF1341; pfam07071 1249634012484 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 1249634012485 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1249634012486 catalytic residue [active] 1249634012487 dihydroorotase; Provisional; Region: PRK09237 1249634012488 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1249634012489 active site 1249634012490 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 1249634012491 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 1249634012492 Domain of unknown function (DUF4312); Region: DUF4312; pfam14189 1249634012493 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; pfam14272 1249634012494 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 1249634012495 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1249634012496 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1249634012497 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1249634012498 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1249634012499 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1249634012500 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1249634012501 Cytochrome b562; Region: Cytochrom_B562; cl01546 1249634012502 peptidase PmbA; Provisional; Region: PRK11040 1249634012503 hypothetical protein; Provisional; Region: PRK05255 1249634012504 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1249634012505 RNAase interaction site [polypeptide binding]; other site 1249634012506 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 1249634012507 active site 1249634012508 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 1249634012509 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1249634012510 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 1249634012511 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1249634012512 HlyD family secretion protein; Region: HlyD_3; pfam13437 1249634012513 efflux system membrane protein; Provisional; Region: PRK11594 1249634012514 transcriptional regulator; Provisional; Region: PRK10632 1249634012515 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634012516 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1249634012517 putative effector binding pocket; other site 1249634012518 dimerization interface [polypeptide binding]; other site 1249634012519 protease TldD; Provisional; Region: tldD; PRK10735 1249634012520 nitrilase; Region: PLN02798 1249634012521 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 1249634012522 putative active site [active] 1249634012523 catalytic triad [active] 1249634012524 dimer interface [polypeptide binding]; other site 1249634012525 hypothetical protein; Provisional; Region: PRK10899 1249634012526 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1249634012527 ribonuclease G; Provisional; Region: PRK11712 1249634012528 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1249634012529 homodimer interface [polypeptide binding]; other site 1249634012530 oligonucleotide binding site [chemical binding]; other site 1249634012531 Maf-like protein; Region: Maf; pfam02545 1249634012532 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1249634012533 active site 1249634012534 dimer interface [polypeptide binding]; other site 1249634012535 rod shape-determining protein MreD; Provisional; Region: PRK11060 1249634012536 rod shape-determining protein MreC; Region: mreC; TIGR00219 1249634012537 rod shape-determining protein MreC; Region: MreC; pfam04085 1249634012538 rod shape-determining protein MreB; Provisional; Region: PRK13927 1249634012539 MreB and similar proteins; Region: MreB_like; cd10225 1249634012540 nucleotide binding site [chemical binding]; other site 1249634012541 Mg binding site [ion binding]; other site 1249634012542 putative protofilament interaction site [polypeptide binding]; other site 1249634012543 RodZ interaction site [polypeptide binding]; other site 1249634012544 regulatory protein CsrD; Provisional; Region: PRK11059 1249634012545 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1249634012546 metal binding site [ion binding]; metal-binding site 1249634012547 active site 1249634012548 I-site; other site 1249634012549 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1249634012550 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1249634012551 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1249634012552 NADP binding site [chemical binding]; other site 1249634012553 dimer interface [polypeptide binding]; other site 1249634012554 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1249634012555 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 1249634012556 Moco binding site; other site 1249634012557 metal coordination site [ion binding]; other site 1249634012558 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1249634012559 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1249634012560 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1249634012561 active site 1249634012562 trimer interface [polypeptide binding]; other site 1249634012563 dimer interface [polypeptide binding]; other site 1249634012564 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1249634012565 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1249634012566 carboxyltransferase (CT) interaction site; other site 1249634012567 biotinylation site [posttranslational modification]; other site 1249634012568 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1249634012569 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1249634012570 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1249634012571 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1249634012572 hypothetical protein; Provisional; Region: PRK10633 1249634012573 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1249634012574 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 1249634012575 Na binding site [ion binding]; other site 1249634012576 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1249634012577 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1249634012578 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 1249634012579 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1249634012580 FMN binding site [chemical binding]; other site 1249634012581 active site 1249634012582 catalytic residues [active] 1249634012583 substrate binding site [chemical binding]; other site 1249634012584 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 1249634012585 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 1249634012586 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1249634012587 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1249634012588 putative acyl-acceptor binding pocket; other site 1249634012589 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1249634012590 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1249634012591 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634012592 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634012593 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1249634012594 putative dimerization interface [polypeptide binding]; other site 1249634012595 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1249634012596 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1249634012597 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1249634012598 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1249634012599 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1249634012600 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1249634012601 putative C-terminal domain interface [polypeptide binding]; other site 1249634012602 putative GSH binding site (G-site) [chemical binding]; other site 1249634012603 putative dimer interface [polypeptide binding]; other site 1249634012604 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 1249634012605 putative N-terminal domain interface [polypeptide binding]; other site 1249634012606 putative dimer interface [polypeptide binding]; other site 1249634012607 putative substrate binding pocket (H-site) [chemical binding]; other site 1249634012608 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 1249634012609 Transcriptional regulator; Region: Rrf2; pfam02082 1249634012610 Rrf2 family protein; Region: rrf2_super; TIGR00738 1249634012611 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1249634012612 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1249634012613 dimer interface [polypeptide binding]; other site 1249634012614 ssDNA binding site [nucleotide binding]; other site 1249634012615 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1249634012616 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1249634012617 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1249634012618 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1249634012619 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1249634012620 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1249634012621 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1249634012622 putative NAD(P) binding site [chemical binding]; other site 1249634012623 putative substrate binding site [chemical binding]; other site 1249634012624 catalytic Zn binding site [ion binding]; other site 1249634012625 structural Zn binding site [ion binding]; other site 1249634012626 dimer interface [polypeptide binding]; other site 1249634012627 maltose O-acetyltransferase; Provisional; Region: PRK10092 1249634012628 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1249634012629 active site 1249634012630 substrate binding site [chemical binding]; other site 1249634012631 trimer interface [polypeptide binding]; other site 1249634012632 CoA binding site [chemical binding]; other site 1249634012633 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1249634012634 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1249634012635 DNA binding site [nucleotide binding] 1249634012636 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 1249634012637 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1249634012638 putative ligand binding site [chemical binding]; other site 1249634012639 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1249634012640 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1249634012641 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 1249634012642 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1249634012643 TrkA-N domain; Region: TrkA_N; pfam02254 1249634012644 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1249634012645 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1249634012646 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1249634012647 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1249634012648 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1249634012649 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1249634012650 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634012651 homodimer interface [polypeptide binding]; other site 1249634012652 catalytic residue [active] 1249634012653 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1249634012654 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1249634012655 putative DNA binding site [nucleotide binding]; other site 1249634012656 putative Zn2+ binding site [ion binding]; other site 1249634012657 AsnC family; Region: AsnC_trans_reg; pfam01037 1249634012658 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1249634012659 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1249634012660 substrate binding pocket [chemical binding]; other site 1249634012661 membrane-bound complex binding site; other site 1249634012662 hinge residues; other site 1249634012663 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 1249634012664 FGGY-family pentulose kinase; Region: 5C_CHO_kinase; TIGR01315 1249634012665 N- and C-terminal domain interface [polypeptide binding]; other site 1249634012666 active site 1249634012667 MgATP binding site [chemical binding]; other site 1249634012668 catalytic site [active] 1249634012669 metal binding site [ion binding]; metal-binding site 1249634012670 carbohydrate binding site [chemical binding]; other site 1249634012671 putative homodimer interface [polypeptide binding]; other site 1249634012672 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1249634012673 classical (c) SDRs; Region: SDR_c; cd05233 1249634012674 NAD(P) binding site [chemical binding]; other site 1249634012675 active site 1249634012676 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1249634012677 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1249634012678 DNA binding site [nucleotide binding] 1249634012679 domain linker motif; other site 1249634012680 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1249634012681 dimerization interface [polypeptide binding]; other site 1249634012682 ligand binding site [chemical binding]; other site 1249634012683 alanine racemase; Reviewed; Region: alr; PRK00053 1249634012684 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1249634012685 active site 1249634012686 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1249634012687 substrate binding site [chemical binding]; other site 1249634012688 catalytic residues [active] 1249634012689 dimer interface [polypeptide binding]; other site 1249634012690 replicative DNA helicase; Provisional; Region: PRK08006 1249634012691 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1249634012692 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1249634012693 Walker A motif; other site 1249634012694 ATP binding site [chemical binding]; other site 1249634012695 Walker B motif; other site 1249634012696 DNA binding loops [nucleotide binding] 1249634012697 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1249634012698 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1249634012699 NADP binding site [chemical binding]; other site 1249634012700 dimer interface [polypeptide binding]; other site 1249634012701 phage shock protein G; Reviewed; Region: pspG; PRK09459 1249634012702 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1249634012703 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1249634012704 FMN binding site [chemical binding]; other site 1249634012705 active site 1249634012706 catalytic residues [active] 1249634012707 substrate binding site [chemical binding]; other site 1249634012708 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1249634012709 metal binding site 2 [ion binding]; metal-binding site 1249634012710 putative DNA binding helix; other site 1249634012711 metal binding site 1 [ion binding]; metal-binding site 1249634012712 dimer interface [polypeptide binding]; other site 1249634012713 structural Zn2+ binding site [ion binding]; other site 1249634012714 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 1249634012715 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1249634012716 LexA repressor; Validated; Region: PRK00215 1249634012717 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1249634012718 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1249634012719 Catalytic site [active] 1249634012720 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1249634012721 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 1249634012722 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1249634012723 putative acyl-acceptor binding pocket; other site 1249634012724 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1249634012725 UbiA prenyltransferase family; Region: UbiA; pfam01040 1249634012726 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 1249634012727 maltose regulon periplasmic protein; Provisional; Region: PRK10564 1249634012728 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1249634012729 trimer interface; other site 1249634012730 sugar binding site [chemical binding]; other site 1249634012731 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 1249634012732 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1249634012733 Walker A/P-loop; other site 1249634012734 ATP binding site [chemical binding]; other site 1249634012735 Q-loop/lid; other site 1249634012736 ABC transporter signature motif; other site 1249634012737 Walker B; other site 1249634012738 D-loop; other site 1249634012739 H-loop/switch region; other site 1249634012740 TOBE domain; Region: TOBE_2; pfam08402 1249634012741 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 1249634012742 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1249634012743 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634012744 dimer interface [polypeptide binding]; other site 1249634012745 conserved gate region; other site 1249634012746 putative PBP binding loops; other site 1249634012747 ABC-ATPase subunit interface; other site 1249634012748 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1249634012749 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634012750 dimer interface [polypeptide binding]; other site 1249634012751 conserved gate region; other site 1249634012752 putative PBP binding loops; other site 1249634012753 ABC-ATPase subunit interface; other site 1249634012754 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 1249634012755 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 1249634012756 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1249634012757 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1249634012758 NAD binding site [chemical binding]; other site 1249634012759 substrate binding site [chemical binding]; other site 1249634012760 catalytic Zn binding site [ion binding]; other site 1249634012761 tetramer interface [polypeptide binding]; other site 1249634012762 structural Zn binding site [ion binding]; other site 1249634012763 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1249634012764 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1249634012765 active site 1249634012766 dimer interface [polypeptide binding]; other site 1249634012767 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1249634012768 dimer interface [polypeptide binding]; other site 1249634012769 active site 1249634012770 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1249634012771 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1249634012772 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1249634012773 TrkA-N domain; Region: TrkA_N; pfam02254 1249634012774 aspartate kinase III; Validated; Region: PRK09084 1249634012775 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1249634012776 nucleotide binding site [chemical binding]; other site 1249634012777 substrate binding site [chemical binding]; other site 1249634012778 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1249634012779 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 1249634012780 dimer interface [polypeptide binding]; other site 1249634012781 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1249634012782 Sodium Bile acid symporter family; Region: SBF; pfam01758 1249634012783 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1249634012784 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1249634012785 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1249634012786 short chain dehydrogenase; Validated; Region: PRK07069 1249634012787 NAD(P) binding site [chemical binding]; other site 1249634012788 active site 1249634012789 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1249634012790 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1249634012791 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1249634012792 substrate binding pocket [chemical binding]; other site 1249634012793 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1249634012794 B12 binding site [chemical binding]; other site 1249634012795 cobalt ligand [ion binding]; other site 1249634012796 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1249634012797 transcriptional repressor IclR; Provisional; Region: PRK11569 1249634012798 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1249634012799 Bacterial transcriptional regulator; Region: IclR; pfam01614 1249634012800 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1249634012801 ATP-binding site [chemical binding]; other site 1249634012802 Gluconate-6-phosphate binding site [chemical binding]; other site 1249634012803 low affinity gluconate transporter; Provisional; Region: PRK10472 1249634012804 GntP family permease; Region: GntP_permease; pfam02447 1249634012805 phosphogluconate dehydratase; Validated; Region: PRK09054 1249634012806 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1249634012807 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1249634012808 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1249634012809 active site 1249634012810 intersubunit interface [polypeptide binding]; other site 1249634012811 catalytic residue [active] 1249634012812 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 1249634012813 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 1249634012814 isocitrate lyase; Provisional; Region: PRK15063 1249634012815 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1249634012816 tetramer interface [polypeptide binding]; other site 1249634012817 active site 1249634012818 Mg2+/Mn2+ binding site [ion binding]; other site 1249634012819 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 1249634012820 malate synthase A; Region: malate_syn_A; TIGR01344 1249634012821 active site 1249634012822 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1249634012823 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1249634012824 proposed active site lysine [active] 1249634012825 conserved cys residue [active] 1249634012826 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1249634012827 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1249634012828 trimer interface [polypeptide binding]; other site 1249634012829 putative metal binding site [ion binding]; other site 1249634012830 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1249634012831 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1249634012832 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1249634012833 shikimate binding site; other site 1249634012834 NAD(P) binding site [chemical binding]; other site 1249634012835 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1249634012836 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1249634012837 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1249634012838 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1249634012839 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1249634012840 hypothetical protein; Validated; Region: PRK03430 1249634012841 hypothetical protein; Provisional; Region: PRK10736 1249634012842 DNA protecting protein DprA; Region: dprA; TIGR00732 1249634012843 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1249634012844 active site 1249634012845 catalytic residues [active] 1249634012846 metal binding site [ion binding]; metal-binding site 1249634012847 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1249634012848 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1249634012849 putative active site [active] 1249634012850 substrate binding site [chemical binding]; other site 1249634012851 putative cosubstrate binding site; other site 1249634012852 catalytic site [active] 1249634012853 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1249634012854 substrate binding site [chemical binding]; other site 1249634012855 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1249634012856 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1249634012857 putative RNA binding site [nucleotide binding]; other site 1249634012858 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1249634012859 S-adenosylmethionine binding site [chemical binding]; other site 1249634012860 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1249634012861 TrkA-N domain; Region: TrkA_N; pfam02254 1249634012862 TrkA-C domain; Region: TrkA_C; pfam02080 1249634012863 TrkA-N domain; Region: TrkA_N; pfam02254 1249634012864 TrkA-C domain; Region: TrkA_C; pfam02080 1249634012865 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1249634012866 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1249634012867 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 1249634012868 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 1249634012869 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1249634012870 DNA binding residues [nucleotide binding] 1249634012871 dimer interface [polypeptide binding]; other site 1249634012872 metal binding site [ion binding]; metal-binding site 1249634012873 hypothetical protein; Provisional; Region: PRK10203 1249634012874 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1249634012875 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1249634012876 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1249634012877 alphaNTD homodimer interface [polypeptide binding]; other site 1249634012878 alphaNTD - beta interaction site [polypeptide binding]; other site 1249634012879 alphaNTD - beta' interaction site [polypeptide binding]; other site 1249634012880 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1249634012881 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1249634012882 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1249634012883 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1249634012884 RNA binding surface [nucleotide binding]; other site 1249634012885 30S ribosomal protein S11; Validated; Region: PRK05309 1249634012886 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1249634012887 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1249634012888 Alpha operon ribosome binding site; IMG reference gene:2517285639; D781_4249 1249634012889 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 1249634012890 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1249634012891 SecY translocase; Region: SecY; pfam00344 1249634012892 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1249634012893 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1249634012894 23S rRNA binding site [nucleotide binding]; other site 1249634012895 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1249634012896 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1249634012897 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1249634012898 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1249634012899 23S rRNA interface [nucleotide binding]; other site 1249634012900 5S rRNA interface [nucleotide binding]; other site 1249634012901 L27 interface [polypeptide binding]; other site 1249634012902 L5 interface [polypeptide binding]; other site 1249634012903 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1249634012904 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1249634012905 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1249634012906 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1249634012907 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1249634012908 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1249634012909 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1249634012910 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1249634012911 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1249634012912 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1249634012913 RNA binding site [nucleotide binding]; other site 1249634012914 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1249634012915 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1249634012916 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1249634012917 23S rRNA interface [nucleotide binding]; other site 1249634012918 putative translocon interaction site; other site 1249634012919 signal recognition particle (SRP54) interaction site; other site 1249634012920 L23 interface [polypeptide binding]; other site 1249634012921 trigger factor interaction site; other site 1249634012922 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1249634012923 23S rRNA interface [nucleotide binding]; other site 1249634012924 5S rRNA interface [nucleotide binding]; other site 1249634012925 putative antibiotic binding site [chemical binding]; other site 1249634012926 L25 interface [polypeptide binding]; other site 1249634012927 L27 interface [polypeptide binding]; other site 1249634012928 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1249634012929 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1249634012930 G-X-X-G motif; other site 1249634012931 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1249634012932 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1249634012933 protein-rRNA interface [nucleotide binding]; other site 1249634012934 putative translocon binding site; other site 1249634012935 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1249634012936 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1249634012937 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1249634012938 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1249634012939 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1249634012940 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1249634012941 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1249634012942 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1249634012943 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1249634012944 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1249634012945 heme binding site [chemical binding]; other site 1249634012946 ferroxidase pore; other site 1249634012947 ferroxidase diiron center [ion binding]; other site 1249634012948 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 1249634012949 elongation factor Tu; Reviewed; Region: PRK00049 1249634012950 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1249634012951 G1 box; other site 1249634012952 GEF interaction site [polypeptide binding]; other site 1249634012953 GTP/Mg2+ binding site [chemical binding]; other site 1249634012954 Switch I region; other site 1249634012955 G2 box; other site 1249634012956 G3 box; other site 1249634012957 Switch II region; other site 1249634012958 G4 box; other site 1249634012959 G5 box; other site 1249634012960 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1249634012961 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1249634012962 Antibiotic Binding Site [chemical binding]; other site 1249634012963 elongation factor G; Reviewed; Region: PRK00007 1249634012964 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1249634012965 G1 box; other site 1249634012966 putative GEF interaction site [polypeptide binding]; other site 1249634012967 GTP/Mg2+ binding site [chemical binding]; other site 1249634012968 Switch I region; other site 1249634012969 G2 box; other site 1249634012970 G3 box; other site 1249634012971 Switch II region; other site 1249634012972 G4 box; other site 1249634012973 G5 box; other site 1249634012974 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1249634012975 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1249634012976 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1249634012977 30S ribosomal protein S7; Validated; Region: PRK05302 1249634012978 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1249634012979 S17 interaction site [polypeptide binding]; other site 1249634012980 S8 interaction site; other site 1249634012981 16S rRNA interaction site [nucleotide binding]; other site 1249634012982 streptomycin interaction site [chemical binding]; other site 1249634012983 23S rRNA interaction site [nucleotide binding]; other site 1249634012984 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1249634012985 DsrH like protein; Region: DsrH; cl17347 1249634012986 sulfur relay protein TusC; Validated; Region: PRK00211 1249634012987 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 1249634012988 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1249634012989 YheO-like PAS domain; Region: PAS_6; pfam08348 1249634012990 HTH domain; Region: HTH_22; pfam13309 1249634012991 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 1249634012992 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1249634012993 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1249634012994 phi X174 lysis protein; Provisional; Region: PRK02793 1249634012995 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737 1249634012996 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1249634012997 Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526 1249634012998 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 1249634012999 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1249634013000 TrkA-N domain; Region: TrkA_N; pfam02254 1249634013001 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 1249634013002 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1249634013003 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1249634013004 Walker A/P-loop; other site 1249634013005 ATP binding site [chemical binding]; other site 1249634013006 Q-loop/lid; other site 1249634013007 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1249634013008 ABC transporter; Region: ABC_tran_2; pfam12848 1249634013009 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1249634013010 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1249634013011 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 1249634013012 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1249634013013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634013014 dimer interface [polypeptide binding]; other site 1249634013015 conserved gate region; other site 1249634013016 putative PBP binding loops; other site 1249634013017 ABC-ATPase subunit interface; other site 1249634013018 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 1249634013019 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1249634013020 Walker A/P-loop; other site 1249634013021 ATP binding site [chemical binding]; other site 1249634013022 Q-loop/lid; other site 1249634013023 ABC transporter signature motif; other site 1249634013024 Walker B; other site 1249634013025 D-loop; other site 1249634013026 H-loop/switch region; other site 1249634013027 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 1249634013028 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1249634013029 substrate binding pocket [chemical binding]; other site 1249634013030 membrane-bound complex binding site; other site 1249634013031 hinge residues; other site 1249634013032 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1249634013033 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1249634013034 putative hydrolase; Provisional; Region: PRK10985 1249634013035 hypothetical protein; Provisional; Region: PRK04966 1249634013036 phosphoribulokinase; Provisional; Region: PRK15453 1249634013037 hypothetical protein; Provisional; Region: PRK10738 1249634013038 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1249634013039 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1249634013040 ligand binding site [chemical binding]; other site 1249634013041 flexible hinge region; other site 1249634013042 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1249634013043 putative switch regulator; other site 1249634013044 non-specific DNA interactions [nucleotide binding]; other site 1249634013045 DNA binding site [nucleotide binding] 1249634013046 sequence specific DNA binding site [nucleotide binding]; other site 1249634013047 putative cAMP binding site [chemical binding]; other site 1249634013048 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 1249634013049 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1249634013050 inhibitor-cofactor binding pocket; inhibition site 1249634013051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634013052 catalytic residue [active] 1249634013053 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1249634013054 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1249634013055 glutamine binding [chemical binding]; other site 1249634013056 catalytic triad [active] 1249634013057 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1249634013058 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1249634013059 Walker A motif; other site 1249634013060 ATP binding site [chemical binding]; other site 1249634013061 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 1249634013062 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634013063 active site 1249634013064 phosphorylation site [posttranslational modification] 1249634013065 intermolecular recognition site; other site 1249634013066 dimerization interface [polypeptide binding]; other site 1249634013067 LytTr DNA-binding domain; Region: LytTR; pfam04397 1249634013068 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1249634013069 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1249634013070 Histidine kinase; Region: His_kinase; pfam06580 1249634013071 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1249634013072 ATP binding site [chemical binding]; other site 1249634013073 Mg2+ binding site [ion binding]; other site 1249634013074 G-X-G motif; other site 1249634013075 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 1249634013076 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1249634013077 active site 1249634013078 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1249634013079 active site 1249634013080 P-loop; other site 1249634013081 phosphorylation site [posttranslational modification] 1249634013082 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1249634013083 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1249634013084 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1249634013085 active site 1249634013086 methionine cluster; other site 1249634013087 phosphorylation site [posttranslational modification] 1249634013088 metal binding site [ion binding]; metal-binding site 1249634013089 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1249634013090 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1249634013091 NAD binding site [chemical binding]; other site 1249634013092 sugar binding site [chemical binding]; other site 1249634013093 divalent metal binding site [ion binding]; other site 1249634013094 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1249634013095 dimer interface [polypeptide binding]; other site 1249634013096 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1249634013097 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1249634013098 DNA binding site [nucleotide binding] 1249634013099 domain linker motif; other site 1249634013100 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1249634013101 dimerization interface (closed form) [polypeptide binding]; other site 1249634013102 ligand binding site [chemical binding]; other site 1249634013103 putative transporter; Provisional; Region: PRK03699 1249634013104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634013105 putative substrate translocation pore; other site 1249634013106 cytosine deaminase; Provisional; Region: PRK09230 1249634013107 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1249634013108 active site 1249634013109 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1249634013110 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1249634013111 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1249634013112 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1249634013113 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1249634013114 nitrite transporter NirC; Provisional; Region: PRK11562 1249634013115 siroheme synthase; Provisional; Region: cysG; PRK10637 1249634013116 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1249634013117 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1249634013118 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1249634013119 active site 1249634013120 SAM binding site [chemical binding]; other site 1249634013121 homodimer interface [polypeptide binding]; other site 1249634013122 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1249634013123 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1249634013124 active site 1249634013125 HIGH motif; other site 1249634013126 dimer interface [polypeptide binding]; other site 1249634013127 KMSKS motif; other site 1249634013128 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1249634013129 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1249634013130 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1249634013131 motif II; other site 1249634013132 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1249634013133 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1249634013134 substrate binding site [chemical binding]; other site 1249634013135 hexamer interface [polypeptide binding]; other site 1249634013136 metal binding site [ion binding]; metal-binding site 1249634013137 DNA adenine methylase; Provisional; Region: PRK10904 1249634013138 hypothetical protein; Reviewed; Region: PRK11901 1249634013139 cell division protein DamX; Validated; Region: PRK10905 1249634013140 cell division protein DamX; Validated; Region: PRK10905 1249634013141 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1249634013142 active site 1249634013143 dimer interface [polypeptide binding]; other site 1249634013144 metal binding site [ion binding]; metal-binding site 1249634013145 shikimate kinase; Reviewed; Region: aroK; PRK00131 1249634013146 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1249634013147 ADP binding site [chemical binding]; other site 1249634013148 magnesium binding site [ion binding]; other site 1249634013149 putative shikimate binding site; other site 1249634013150 putative outer membrane porin HofQ; Provisional; Region: hofQ; PRK13568 1249634013151 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1249634013152 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1249634013153 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 1249634013154 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 1249634013155 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 1249634013156 Transglycosylase; Region: Transgly; pfam00912 1249634013157 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1249634013158 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1249634013159 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1249634013160 ADP-ribose binding site [chemical binding]; other site 1249634013161 dimer interface [polypeptide binding]; other site 1249634013162 active site 1249634013163 nudix motif; other site 1249634013164 metal binding site [ion binding]; metal-binding site 1249634013165 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 1249634013166 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1249634013167 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1249634013168 active site 1249634013169 motif I; other site 1249634013170 motif II; other site 1249634013171 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1249634013172 RNA binding surface [nucleotide binding]; other site 1249634013173 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1249634013174 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1249634013175 dimerization interface [polypeptide binding]; other site 1249634013176 domain crossover interface; other site 1249634013177 redox-dependent activation switch; other site 1249634013178 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1249634013179 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1249634013180 active site 1249634013181 substrate-binding site [chemical binding]; other site 1249634013182 metal-binding site [ion binding] 1249634013183 ATP binding site [chemical binding]; other site 1249634013184 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1249634013185 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1249634013186 oligomeric interface; other site 1249634013187 putative active site [active] 1249634013188 homodimer interface [polypeptide binding]; other site 1249634013189 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1249634013190 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1249634013191 dimerization interface [polypeptide binding]; other site 1249634013192 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1249634013193 dimer interface [polypeptide binding]; other site 1249634013194 phosphorylation site [posttranslational modification] 1249634013195 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1249634013196 ATP binding site [chemical binding]; other site 1249634013197 G-X-G motif; other site 1249634013198 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1249634013199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634013200 active site 1249634013201 phosphorylation site [posttranslational modification] 1249634013202 intermolecular recognition site; other site 1249634013203 dimerization interface [polypeptide binding]; other site 1249634013204 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1249634013205 DNA binding site [nucleotide binding] 1249634013206 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1249634013207 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1249634013208 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1249634013209 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1249634013210 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1249634013211 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1249634013212 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1249634013213 RNA binding site [nucleotide binding]; other site 1249634013214 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 1249634013215 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 1249634013216 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1249634013217 G1 box; other site 1249634013218 GTP/Mg2+ binding site [chemical binding]; other site 1249634013219 Switch I region; other site 1249634013220 G2 box; other site 1249634013221 G3 box; other site 1249634013222 Switch II region; other site 1249634013223 G4 box; other site 1249634013224 G5 box; other site 1249634013225 Nucleoside recognition; Region: Gate; pfam07670 1249634013226 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1249634013227 Nucleoside recognition; Region: Gate; pfam07670 1249634013228 Nucleoside recognition; Region: Gate; pfam07670 1249634013229 FeoC like transcriptional regulator; Region: FeoC; cl17677 1249634013230 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 1249634013231 carboxylesterase BioH; Provisional; Region: PRK10349 1249634013232 DNA utilization protein GntX; Provisional; Region: PRK11595 1249634013233 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1249634013234 active site 1249634013235 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 1249634013236 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1249634013237 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1249634013238 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1249634013239 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1249634013240 maltodextrin phosphorylase; Provisional; Region: PRK14985 1249634013241 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1249634013242 active site pocket [active] 1249634013243 transcriptional regulator MalT; Provisional; Region: PRK04841 1249634013244 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1249634013245 DNA binding residues [nucleotide binding] 1249634013246 dimerization interface [polypeptide binding]; other site 1249634013247 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1249634013248 active site residue [active] 1249634013249 intramembrane serine protease GlpG; Provisional; Region: PRK10907 1249634013250 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 1249634013251 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1249634013252 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 1249634013253 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1249634013254 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1249634013255 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1249634013256 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 1249634013257 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 1249634013258 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 1249634013259 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1249634013260 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1249634013261 low affinity gluconate transporter; Provisional; Region: PRK10472 1249634013262 gluconate transporter; Region: gntP; TIGR00791 1249634013263 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1249634013264 ATP-binding site [chemical binding]; other site 1249634013265 Gluconate-6-phosphate binding site [chemical binding]; other site 1249634013266 Shikimate kinase; Region: SKI; pfam01202 1249634013267 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 1249634013268 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1249634013269 DNA binding site [nucleotide binding] 1249634013270 domain linker motif; other site 1249634013271 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1249634013272 putative ligand binding site [chemical binding]; other site 1249634013273 putative dimerization interface [polypeptide binding]; other site 1249634013274 Pirin-related protein [General function prediction only]; Region: COG1741 1249634013275 Pirin; Region: Pirin; pfam02678 1249634013276 putative acetyltransferase YhhY; Provisional; Region: PRK10140 1249634013277 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1249634013278 Coenzyme A binding pocket [chemical binding]; other site 1249634013279 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1249634013280 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1249634013281 Metal-binding active site; metal-binding site 1249634013282 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1249634013283 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1249634013284 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1249634013285 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1249634013286 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1249634013287 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1249634013288 PYR/PP interface [polypeptide binding]; other site 1249634013289 dimer interface [polypeptide binding]; other site 1249634013290 TPP binding site [chemical binding]; other site 1249634013291 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1249634013292 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1249634013293 TPP-binding site; other site 1249634013294 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1249634013295 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1249634013296 substrate binding site [chemical binding]; other site 1249634013297 ATP binding site [chemical binding]; other site 1249634013298 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 1249634013299 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 1249634013300 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1249634013301 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1249634013302 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1249634013303 putative active site [active] 1249634013304 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 1249634013305 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1249634013306 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1249634013307 tetrameric interface [polypeptide binding]; other site 1249634013308 NAD binding site [chemical binding]; other site 1249634013309 catalytic residues [active] 1249634013310 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1249634013311 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634013312 putative substrate translocation pore; other site 1249634013313 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634013314 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 1249634013315 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1249634013316 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 1249634013317 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1249634013318 Walker A/P-loop; other site 1249634013319 ATP binding site [chemical binding]; other site 1249634013320 Q-loop/lid; other site 1249634013321 ABC transporter signature motif; other site 1249634013322 Walker B; other site 1249634013323 D-loop; other site 1249634013324 H-loop/switch region; other site 1249634013325 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 1249634013326 homotrimer interaction site [polypeptide binding]; other site 1249634013327 putative active site [active] 1249634013328 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634013329 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634013330 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1249634013331 putative effector binding pocket; other site 1249634013332 putative dimerization interface [polypeptide binding]; other site 1249634013333 Predicted flavoproteins [General function prediction only]; Region: COG2081 1249634013334 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1249634013335 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1249634013336 universal stress protein UspB; Provisional; Region: PRK04960 1249634013337 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1249634013338 Ligand Binding Site [chemical binding]; other site 1249634013339 glutamate dehydrogenase; Provisional; Region: PRK09414 1249634013340 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1249634013341 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1249634013342 NAD(P) binding site [chemical binding]; other site 1249634013343 NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530 1249634013344 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1249634013345 active site 1249634013346 metal binding site [ion binding]; metal-binding site 1249634013347 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1249634013348 putative methyltransferase; Provisional; Region: PRK10742 1249634013349 oligopeptidase A; Provisional; Region: PRK10911 1249634013350 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1249634013351 active site 1249634013352 Zn binding site [ion binding]; other site 1249634013353 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1249634013354 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1249634013355 glutathione reductase; Validated; Region: PRK06116 1249634013356 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1249634013357 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1249634013358 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1249634013359 Protein of unknown function (DUF796); Region: DUF796; pfam05638 1249634013360 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1249634013361 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1249634013362 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1249634013363 dimer interface [polypeptide binding]; other site 1249634013364 phosphorylation site [posttranslational modification] 1249634013365 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1249634013366 ATP binding site [chemical binding]; other site 1249634013367 Mg2+ binding site [ion binding]; other site 1249634013368 G-X-G motif; other site 1249634013369 Response regulator receiver domain; Region: Response_reg; pfam00072 1249634013370 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634013371 active site 1249634013372 phosphorylation site [posttranslational modification] 1249634013373 intermolecular recognition site; other site 1249634013374 dimerization interface [polypeptide binding]; other site 1249634013375 BetR domain; Region: BetR; pfam08667 1249634013376 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1249634013377 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1249634013378 hypothetical protein; Provisional; Region: PRK02399 1249634013379 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 1249634013380 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1249634013381 dimer interface [polypeptide binding]; other site 1249634013382 inner membrane protein YhjD; Region: TIGR00766 1249634013383 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634013384 metabolite-proton symporter; Region: 2A0106; TIGR00883 1249634013385 putative substrate translocation pore; other site 1249634013386 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 1249634013387 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1249634013388 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1249634013389 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1249634013390 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1249634013391 substrate binding site [chemical binding]; other site 1249634013392 ATP binding site [chemical binding]; other site 1249634013393 ketol-acid reductoisomerase; Validated; Region: PRK05225 1249634013394 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1249634013395 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1249634013396 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1249634013397 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634013398 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 1249634013399 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 1249634013400 putative dimerization interface [polypeptide binding]; other site 1249634013401 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 1249634013402 threonine dehydratase; Reviewed; Region: PRK09224 1249634013403 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1249634013404 tetramer interface [polypeptide binding]; other site 1249634013405 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634013406 catalytic residue [active] 1249634013407 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1249634013408 putative Ile/Val binding site [chemical binding]; other site 1249634013409 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1249634013410 putative Ile/Val binding site [chemical binding]; other site 1249634013411 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1249634013412 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1249634013413 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1249634013414 homodimer interface [polypeptide binding]; other site 1249634013415 substrate-cofactor binding pocket; other site 1249634013416 catalytic residue [active] 1249634013417 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 1249634013418 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 1249634013419 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1249634013420 PYR/PP interface [polypeptide binding]; other site 1249634013421 dimer interface [polypeptide binding]; other site 1249634013422 TPP binding site [chemical binding]; other site 1249634013423 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1249634013424 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1249634013425 TPP-binding site [chemical binding]; other site 1249634013426 dimer interface [polypeptide binding]; other site 1249634013427 putative sialic acid transporter; Region: 2A0112; TIGR00891 1249634013428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634013429 putative substrate translocation pore; other site 1249634013430 putative ATP-dependent protease; Provisional; Region: PRK09862 1249634013431 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1249634013432 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1249634013433 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1249634013434 hypothetical protein; Provisional; Region: PRK11027 1249634013435 transcriptional regulator HdfR; Provisional; Region: PRK03601 1249634013436 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634013437 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1249634013438 dimerization interface [polypeptide binding]; other site 1249634013439 glutamate racemase; Provisional; Region: PRK00865 1249634013440 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 1249634013441 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1249634013442 N-terminal plug; other site 1249634013443 ligand-binding site [chemical binding]; other site 1249634013444 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 1249634013445 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1249634013446 S-adenosylmethionine binding site [chemical binding]; other site 1249634013447 hypothetical protein; Provisional; Region: PRK11056 1249634013448 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1249634013449 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1249634013450 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1249634013451 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1249634013452 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1249634013453 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1249634013454 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634013455 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1249634013456 dimerization interface [polypeptide binding]; other site 1249634013457 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 1249634013458 catalytic triad [active] 1249634013459 dimer interface [polypeptide binding]; other site 1249634013460 Glutaredoxin (GRX) family, PRX5 hybrid subfamily; composed of hybrid proteins containing peroxiredoxin (PRX) and GRX domains, which is found in some pathogenic bacteria and cyanobacteria. PRXs are thiol-specific antioxidant (TSA) proteins that confer a...; Region: GRX_hybridPRX5; cd03029 1249634013461 GSH binding site [chemical binding]; other site 1249634013462 catalytic residues [active] 1249634013463 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 1249634013464 HicB family; Region: HicB; pfam05534 1249634013465 argininosuccinate lyase; Provisional; Region: PRK04833 1249634013466 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1249634013467 active sites [active] 1249634013468 tetramer interface [polypeptide binding]; other site 1249634013469 argininosuccinate synthase; Provisional; Region: PRK13820 1249634013470 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1249634013471 ANP binding site [chemical binding]; other site 1249634013472 Substrate Binding Site II [chemical binding]; other site 1249634013473 Substrate Binding Site I [chemical binding]; other site 1249634013474 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 1249634013475 nucleotide binding site [chemical binding]; other site 1249634013476 N-acetyl-L-glutamate binding site [chemical binding]; other site 1249634013477 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1249634013478 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1249634013479 acetylornithine deacetylase; Provisional; Region: PRK05111 1249634013480 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1249634013481 metal binding site [ion binding]; metal-binding site 1249634013482 putative dimer interface [polypeptide binding]; other site 1249634013483 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1249634013484 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1249634013485 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1249634013486 FAD binding site [chemical binding]; other site 1249634013487 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 1249634013488 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1249634013489 putative catalytic residues [active] 1249634013490 putative nucleotide binding site [chemical binding]; other site 1249634013491 putative aspartate binding site [chemical binding]; other site 1249634013492 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 1249634013493 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1249634013494 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1249634013495 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 1249634013496 dimerization interface [polypeptide binding]; other site 1249634013497 DNA binding site [nucleotide binding] 1249634013498 corepressor binding sites; other site 1249634013499 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1249634013500 primosome assembly protein PriA; Validated; Region: PRK05580 1249634013501 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1249634013502 ATP binding site [chemical binding]; other site 1249634013503 putative Mg++ binding site [ion binding]; other site 1249634013504 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1249634013505 ATP-binding site [chemical binding]; other site 1249634013506 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1249634013507 DNA binding site [nucleotide binding] 1249634013508 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 1249634013509 domain linker motif; other site 1249634013510 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 1249634013511 dimerization interface [polypeptide binding]; other site 1249634013512 ligand binding site [chemical binding]; other site 1249634013513 Sporulation related domain; Region: SPOR; cl10051 1249634013514 Sporulation related domain; Region: SPOR; cl10051 1249634013515 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1249634013516 active site 1249634013517 HslU subunit interaction site [polypeptide binding]; other site 1249634013518 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1249634013519 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1249634013520 Walker A motif; other site 1249634013521 ATP binding site [chemical binding]; other site 1249634013522 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1249634013523 Walker B motif; other site 1249634013524 arginine finger; other site 1249634013525 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1249634013526 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1249634013527 UbiA prenyltransferase family; Region: UbiA; pfam01040 1249634013528 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1249634013529 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3074 1249634013530 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1249634013531 amphipathic channel; other site 1249634013532 Asn-Pro-Ala signature motifs; other site 1249634013533 glycerol kinase; Provisional; Region: glpK; PRK00047 1249634013534 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1249634013535 N- and C-terminal domain interface [polypeptide binding]; other site 1249634013536 active site 1249634013537 MgATP binding site [chemical binding]; other site 1249634013538 catalytic site [active] 1249634013539 metal binding site [ion binding]; metal-binding site 1249634013540 glycerol binding site [chemical binding]; other site 1249634013541 homotetramer interface [polypeptide binding]; other site 1249634013542 homodimer interface [polypeptide binding]; other site 1249634013543 FBP binding site [chemical binding]; other site 1249634013544 protein IIAGlc interface [polypeptide binding]; other site 1249634013545 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1249634013546 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1249634013547 putative active site [active] 1249634013548 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 1249634013549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634013550 putative substrate translocation pore; other site 1249634013551 ferredoxin-NADP reductase; Provisional; Region: PRK10926 1249634013552 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1249634013553 FAD binding pocket [chemical binding]; other site 1249634013554 FAD binding motif [chemical binding]; other site 1249634013555 phosphate binding motif [ion binding]; other site 1249634013556 beta-alpha-beta structure motif; other site 1249634013557 NAD binding pocket [chemical binding]; other site 1249634013558 Predicted membrane protein [Function unknown]; Region: COG3152 1249634013559 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 1249634013560 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1249634013561 triosephosphate isomerase; Provisional; Region: PRK14567 1249634013562 substrate binding site [chemical binding]; other site 1249634013563 dimer interface [polypeptide binding]; other site 1249634013564 catalytic triad [active] 1249634013565 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1249634013566 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1249634013567 substrate binding pocket [chemical binding]; other site 1249634013568 membrane-bound complex binding site; other site 1249634013569 hinge residues; other site 1249634013570 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1249634013571 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1249634013572 active site 1249634013573 ADP/pyrophosphate binding site [chemical binding]; other site 1249634013574 dimerization interface [polypeptide binding]; other site 1249634013575 allosteric effector site; other site 1249634013576 fructose-1,6-bisphosphate binding site; other site 1249634013577 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 1249634013578 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1249634013579 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1249634013580 dimer interface [polypeptide binding]; other site 1249634013581 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 1249634013582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634013583 active site 1249634013584 phosphorylation site [posttranslational modification] 1249634013585 intermolecular recognition site; other site 1249634013586 dimerization interface [polypeptide binding]; other site 1249634013587 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1249634013588 DNA binding site [nucleotide binding] 1249634013589 two-component sensor protein; Provisional; Region: cpxA; PRK09470 1249634013590 HAMP domain; Region: HAMP; pfam00672 1249634013591 dimerization interface [polypeptide binding]; other site 1249634013592 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1249634013593 dimer interface [polypeptide binding]; other site 1249634013594 phosphorylation site [posttranslational modification] 1249634013595 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1249634013596 ATP binding site [chemical binding]; other site 1249634013597 Mg2+ binding site [ion binding]; other site 1249634013598 G-X-G motif; other site 1249634013599 putative rRNA methylase; Provisional; Region: PRK10358 1249634013600 serine acetyltransferase; Provisional; Region: cysE; PRK11132 1249634013601 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 1249634013602 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1249634013603 trimer interface [polypeptide binding]; other site 1249634013604 active site 1249634013605 substrate binding site [chemical binding]; other site 1249634013606 CoA binding site [chemical binding]; other site 1249634013607 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1249634013608 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1249634013609 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1249634013610 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 1249634013611 SecA binding site; other site 1249634013612 Preprotein binding site; other site 1249634013613 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1249634013614 GSH binding site [chemical binding]; other site 1249634013615 catalytic residues [active] 1249634013616 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1249634013617 active site residue [active] 1249634013618 phosphoglyceromutase; Provisional; Region: PRK05434 1249634013619 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1249634013620 AmiB activator; Provisional; Region: PRK11637 1249634013621 Peptidase family M23; Region: Peptidase_M23; pfam01551 1249634013622 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1249634013623 NodB motif; other site 1249634013624 putative active site [active] 1249634013625 putative catalytic site [active] 1249634013626 Zn binding site [ion binding]; other site 1249634013627 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1249634013628 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1249634013629 NAD(P) binding site [chemical binding]; other site 1249634013630 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1249634013631 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1249634013632 substrate-cofactor binding pocket; other site 1249634013633 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1249634013634 catalytic residue [active] 1249634013635 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 1249634013636 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 1249634013637 NADP binding site [chemical binding]; other site 1249634013638 homopentamer interface [polypeptide binding]; other site 1249634013639 substrate binding site [chemical binding]; other site 1249634013640 active site 1249634013641 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1249634013642 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1249634013643 putative active site [active] 1249634013644 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1249634013645 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1249634013646 putative active site [active] 1249634013647 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1249634013648 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1249634013649 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1249634013650 O-Antigen ligase; Region: Wzy_C; pfam04932 1249634013651 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1249634013652 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1249634013653 putative active site [active] 1249634013654 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 1249634013655 putative active site [active] 1249634013656 putative catalytic site [active] 1249634013657 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 1249634013658 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1249634013659 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1249634013660 putative active site [active] 1249634013661 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1249634013662 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1249634013663 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1249634013664 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1249634013665 putative ADP-binding pocket [chemical binding]; other site 1249634013666 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1249634013667 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1249634013668 putative active site [active] 1249634013669 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1249634013670 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1249634013671 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 1249634013672 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1249634013673 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1249634013674 putative metal binding site; other site 1249634013675 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1249634013676 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1249634013677 active site 1249634013678 (T/H)XGH motif; other site 1249634013679 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1249634013680 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1249634013681 DNA binding site [nucleotide binding] 1249634013682 catalytic residue [active] 1249634013683 H2TH interface [polypeptide binding]; other site 1249634013684 putative catalytic residues [active] 1249634013685 turnover-facilitating residue; other site 1249634013686 intercalation triad [nucleotide binding]; other site 1249634013687 8OG recognition residue [nucleotide binding]; other site 1249634013688 putative reading head residues; other site 1249634013689 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1249634013690 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1249634013691 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1249634013692 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1249634013693 hypothetical protein; Reviewed; Region: PRK00024 1249634013694 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1249634013695 MPN+ (JAMM) motif; other site 1249634013696 Zinc-binding site [ion binding]; other site 1249634013697 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1249634013698 Flavoprotein; Region: Flavoprotein; pfam02441 1249634013699 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1249634013700 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1249634013701 trimer interface [polypeptide binding]; other site 1249634013702 active site 1249634013703 division inhibitor protein; Provisional; Region: slmA; PRK09480 1249634013704 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1249634013705 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1249634013706 active site 1249634013707 ribonuclease PH; Reviewed; Region: rph; PRK00173 1249634013708 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1249634013709 hexamer interface [polypeptide binding]; other site 1249634013710 active site 1249634013711 hypothetical protein; Provisional; Region: PRK11820 1249634013712 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1249634013713 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1249634013714 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 1249634013715 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 1249634013716 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1249634013717 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1249634013718 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1249634013719 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1249634013720 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1249634013721 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 1249634013722 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1249634013723 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1249634013724 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1249634013725 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1249634013726 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1249634013727 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1249634013728 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1249634013729 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1249634013730 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1249634013731 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1249634013732 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1249634013733 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1249634013734 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1249634013735 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1249634013736 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1249634013737 active site 1249634013738 Predicted membrane protein [Function unknown]; Region: COG2860 1249634013739 UPF0126 domain; Region: UPF0126; pfam03458 1249634013740 UPF0126 domain; Region: UPF0126; pfam03458 1249634013741 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 1249634013742 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 1249634013743 nucleotide binding pocket [chemical binding]; other site 1249634013744 K-X-D-G motif; other site 1249634013745 catalytic site [active] 1249634013746 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1249634013747 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1249634013748 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1249634013749 catalytic site [active] 1249634013750 G-X2-G-X-G-K; other site 1249634013751 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1249634013752 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 1249634013753 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1249634013754 Zn2+ binding site [ion binding]; other site 1249634013755 Mg2+ binding site [ion binding]; other site 1249634013756 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1249634013757 synthetase active site [active] 1249634013758 NTP binding site [chemical binding]; other site 1249634013759 metal binding site [ion binding]; metal-binding site 1249634013760 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1249634013761 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1249634013762 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 1249634013763 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1249634013764 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 1249634013765 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1249634013766 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1249634013767 generic binding surface II; other site 1249634013768 ssDNA binding site; other site 1249634013769 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1249634013770 ATP binding site [chemical binding]; other site 1249634013771 putative Mg++ binding site [ion binding]; other site 1249634013772 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1249634013773 nucleotide binding region [chemical binding]; other site 1249634013774 ATP-binding site [chemical binding]; other site 1249634013775 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 1249634013776 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1249634013777 AsmA family; Region: AsmA; pfam05170 1249634013778 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1249634013779 Coenzyme A binding pocket [chemical binding]; other site 1249634013780 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 1249634013781 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1249634013782 putative active site [active] 1249634013783 dimerization interface [polypeptide binding]; other site 1249634013784 putative tRNAtyr binding site [nucleotide binding]; other site 1249634013785 hypothetical protein; Reviewed; Region: PRK01637 1249634013786 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1249634013787 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1249634013788 motif II; other site 1249634013789 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1249634013790 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1249634013791 G1 box; other site 1249634013792 putative GEF interaction site [polypeptide binding]; other site 1249634013793 GTP/Mg2+ binding site [chemical binding]; other site 1249634013794 Switch I region; other site 1249634013795 G2 box; other site 1249634013796 G3 box; other site 1249634013797 Switch II region; other site 1249634013798 G4 box; other site 1249634013799 G5 box; other site 1249634013800 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1249634013801 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1249634013802 glutamine synthetase; Provisional; Region: glnA; PRK09469 1249634013803 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1249634013804 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1249634013805 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 1249634013806 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1249634013807 dimer interface [polypeptide binding]; other site 1249634013808 phosphorylation site [posttranslational modification] 1249634013809 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1249634013810 ATP binding site [chemical binding]; other site 1249634013811 Mg2+ binding site [ion binding]; other site 1249634013812 G-X-G motif; other site 1249634013813 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 1249634013814 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1249634013815 active site 1249634013816 phosphorylation site [posttranslational modification] 1249634013817 intermolecular recognition site; other site 1249634013818 dimerization interface [polypeptide binding]; other site 1249634013819 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1249634013820 Walker A motif; other site 1249634013821 ATP binding site [chemical binding]; other site 1249634013822 Walker B motif; other site 1249634013823 arginine finger; other site 1249634013824 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1249634013825 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1249634013826 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1249634013827 FeS/SAM binding site; other site 1249634013828 HemN C-terminal domain; Region: HemN_C; pfam06969 1249634013829 Der GTPase activator; Provisional; Region: PRK05244 1249634013830 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1249634013831 G1 box; other site 1249634013832 GTP/Mg2+ binding site [chemical binding]; other site 1249634013833 Switch I region; other site 1249634013834 G2 box; other site 1249634013835 G3 box; other site 1249634013836 Switch II region; other site 1249634013837 G4 box; other site 1249634013838 G5 box; other site 1249634013839 DNA polymerase I; Provisional; Region: PRK05755 1249634013840 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1249634013841 active site 1249634013842 metal binding site 1 [ion binding]; metal-binding site 1249634013843 putative 5' ssDNA interaction site; other site 1249634013844 metal binding site 3; metal-binding site 1249634013845 metal binding site 2 [ion binding]; metal-binding site 1249634013846 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1249634013847 putative DNA binding site [nucleotide binding]; other site 1249634013848 putative metal binding site [ion binding]; other site 1249634013849 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1249634013850 active site 1249634013851 catalytic site [active] 1249634013852 substrate binding site [chemical binding]; other site 1249634013853 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1249634013854 active site 1249634013855 DNA binding site [nucleotide binding] 1249634013856 catalytic site [active] 1249634013857 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1249634013858 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1249634013859 putative acyl-acceptor binding pocket; other site 1249634013860 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1249634013861 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1249634013862 catalytic residues [active] 1249634013863 hinge region; other site 1249634013864 alpha helical domain; other site 1249634013865 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1249634013866 serine/threonine protein kinase; Provisional; Region: PRK11768 1249634013867 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 1249634013868 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1249634013869 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1249634013870 GTP binding site; other site 1249634013871 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1249634013872 Walker A motif; other site 1249634013873 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1249634013874 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1249634013875 DNA-binding site [nucleotide binding]; DNA binding site 1249634013876 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1249634013877 putative transporter; Provisional; Region: PRK10504 1249634013878 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634013879 putative substrate translocation pore; other site 1249634013880 transcriptional repressor RbsR; Provisional; Region: PRK10423 1249634013881 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1249634013882 DNA binding site [nucleotide binding] 1249634013883 domain linker motif; other site 1249634013884 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1249634013885 dimerization interface [polypeptide binding]; other site 1249634013886 ligand binding site [chemical binding]; other site 1249634013887 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1249634013888 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1249634013889 substrate binding site [chemical binding]; other site 1249634013890 dimer interface [polypeptide binding]; other site 1249634013891 ATP binding site [chemical binding]; other site 1249634013892 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1249634013893 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1249634013894 ligand binding site [chemical binding]; other site 1249634013895 dimerization interface [polypeptide binding]; other site 1249634013896 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1249634013897 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1249634013898 TM-ABC transporter signature motif; other site 1249634013899 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 1249634013900 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1249634013901 Walker A/P-loop; other site 1249634013902 ATP binding site [chemical binding]; other site 1249634013903 Q-loop/lid; other site 1249634013904 ABC transporter signature motif; other site 1249634013905 Walker B; other site 1249634013906 D-loop; other site 1249634013907 H-loop/switch region; other site 1249634013908 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1249634013909 D-ribose pyranase; Provisional; Region: PRK11797 1249634013910 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 1249634013911 potassium uptake protein; Region: kup; TIGR00794 1249634013912 regulatory ATPase RavA; Provisional; Region: PRK13531 1249634013913 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1249634013914 Walker A motif; other site 1249634013915 ATP binding site [chemical binding]; other site 1249634013916 Walker B motif; other site 1249634013917 arginine finger; other site 1249634013918 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 1249634013919 hypothetical protein; Provisional; Region: yieM; PRK10997 1249634013920 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1249634013921 metal ion-dependent adhesion site (MIDAS); other site 1249634013922 Asparagine synthetase A [Amino acid transport and metabolism]; Region: AsnA; COG2502 1249634013923 motif 1; other site 1249634013924 dimer interface [polypeptide binding]; other site 1249634013925 active site 1249634013926 motif 2; other site 1249634013927 motif 3; other site 1249634013928 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 1249634013929 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1249634013930 dimerization interface [polypeptide binding]; other site 1249634013931 putative DNA binding site [nucleotide binding]; other site 1249634013932 putative Zn2+ binding site [ion binding]; other site 1249634013933 AsnC family; Region: AsnC_trans_reg; pfam01037 1249634013934 FMN-binding protein MioC; Provisional; Region: PRK09004 1249634013935 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1249634013936 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1249634013937 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1249634013938 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1249634013939 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1249634013940 S-adenosylmethionine binding site [chemical binding]; other site 1249634013941 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 1249634013942 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1249634013943 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1249634013944 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1249634013945 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1249634013946 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1249634013947 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1249634013948 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1249634013949 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1249634013950 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1249634013951 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1249634013952 beta subunit interaction interface [polypeptide binding]; other site 1249634013953 Walker A motif; other site 1249634013954 ATP binding site [chemical binding]; other site 1249634013955 Walker B motif; other site 1249634013956 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1249634013957 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1249634013958 core domain interface [polypeptide binding]; other site 1249634013959 delta subunit interface [polypeptide binding]; other site 1249634013960 epsilon subunit interface [polypeptide binding]; other site 1249634013961 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1249634013962 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1249634013963 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1249634013964 alpha subunit interaction interface [polypeptide binding]; other site 1249634013965 Walker A motif; other site 1249634013966 ATP binding site [chemical binding]; other site 1249634013967 Walker B motif; other site 1249634013968 inhibitor binding site; inhibition site 1249634013969 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1249634013970 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1249634013971 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1249634013972 gamma subunit interface [polypeptide binding]; other site 1249634013973 epsilon subunit interface [polypeptide binding]; other site 1249634013974 LBP interface [polypeptide binding]; other site 1249634013975 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 1249634013976 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1249634013977 Substrate binding site; other site 1249634013978 Mg++ binding site; other site 1249634013979 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1249634013980 active site 1249634013981 substrate binding site [chemical binding]; other site 1249634013982 CoA binding site [chemical binding]; other site 1249634013983 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1249634013984 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1249634013985 glutaminase active site [active] 1249634013986 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1249634013987 dimer interface [polypeptide binding]; other site 1249634013988 active site 1249634013989 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1249634013990 dimer interface [polypeptide binding]; other site 1249634013991 active site 1249634013992 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1249634013993 substrate binding pocket [chemical binding]; other site 1249634013994 membrane-bound complex binding site; other site 1249634013995 hinge residues; other site 1249634013996 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 1249634013997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634013998 dimer interface [polypeptide binding]; other site 1249634013999 conserved gate region; other site 1249634014000 putative PBP binding loops; other site 1249634014001 ABC-ATPase subunit interface; other site 1249634014002 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 1249634014003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1249634014004 dimer interface [polypeptide binding]; other site 1249634014005 conserved gate region; other site 1249634014006 putative PBP binding loops; other site 1249634014007 ABC-ATPase subunit interface; other site 1249634014008 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 1249634014009 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1249634014010 Walker A/P-loop; other site 1249634014011 ATP binding site [chemical binding]; other site 1249634014012 Q-loop/lid; other site 1249634014013 ABC transporter signature motif; other site 1249634014014 Walker B; other site 1249634014015 D-loop; other site 1249634014016 H-loop/switch region; other site 1249634014017 transcriptional regulator PhoU; Provisional; Region: PRK11115 1249634014018 PhoU domain; Region: PhoU; pfam01895 1249634014019 PhoU domain; Region: PhoU; pfam01895 1249634014020 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1249634014021 nucleophilic elbow; other site 1249634014022 catalytic triad; other site 1249634014023 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 1249634014024 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1249634014025 active site 1249634014026 motif I; other site 1249634014027 motif II; other site 1249634014028 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1249634014029 Predicted esterase [General function prediction only]; Region: COG0400 1249634014030 Predicted flavoprotein [General function prediction only]; Region: COG0431 1249634014031 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1249634014032 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1249634014033 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1249634014034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1249634014035 putative substrate translocation pore; other site 1249634014036 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1249634014037 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1249634014038 active site 1249634014039 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1249634014040 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1249634014041 DNA binding site [nucleotide binding] 1249634014042 domain linker motif; other site 1249634014043 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 1249634014044 putative dimerization interface [polypeptide binding]; other site 1249634014045 putative ligand binding site [chemical binding]; other site 1249634014046 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1249634014047 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1249634014048 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1249634014049 G1 box; other site 1249634014050 GTP/Mg2+ binding site [chemical binding]; other site 1249634014051 Switch I region; other site 1249634014052 G2 box; other site 1249634014053 Switch II region; other site 1249634014054 G3 box; other site 1249634014055 G4 box; other site 1249634014056 G5 box; other site 1249634014057 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1249634014058 membrane protein insertase; Provisional; Region: PRK01318 1249634014059 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1249634014060 hypothetical protein; Validated; Region: PRK00041 1249634014061 ribonuclease P; Reviewed; Region: rnpA; PRK01732 1249634014062 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399