-- dump date 20120504_161554 -- class Genbank::CDS -- table cds_note -- id note YP_002309437.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_002309440.1 IPR009351, Protein of unknown function DUF1006 YP_002309446.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_002309448.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates YP_002309449.1 in Escherichia coli transcription of this gene is enhanced by polyamines YP_002309450.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_002309452.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA YP_002309455.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_002309456.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_002309460.1 TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs YP_002309469.1 FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids YP_002309470.1 includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids YP_002309472.1 IPR007534, Acyl-protein synthetase, LuxE YP_002309481.1 catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters YP_002309482.1 IPR001498, Protein of unknown function UPF0029 YP_002309488.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain YP_002309491.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_002309494.1 IPR007456, Protein of unknown function DUF494 YP_002309498.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis YP_002309501.1 IPR009962, Protein of unknown function DUF1488 YP_002309506.1 IPR000944, Protein of unknown function UPF0074 YP_002309507.1 IPR006837, Protein of unknown function DUF610, YibQ YP_002309508.1 Peptidase S41A, C-terminal protease YP_002309510.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate YP_002309512.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA YP_002309513.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_002309533.1 forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis YP_002309562.1 catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway YP_002309564.1 catalyzes the formation of 4-imidazolone-5-propanoate from urocanate during histidine metabolism YP_002309565.1 catalyzes the degradation of histidine to urocanate and ammmonia YP_002309573.1 similar to superfamily SSF56935 Porins YP_002309576.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer YP_002309579.1 IPR007801, Protein of unknown function DUF692 YP_002309595.1 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase YP_002309599.1 DHBP synthase; functions during riboflavin biosynthesis YP_002309601.1 Excinuclease ABC, C subunit, N-terminal YP_002309604.1 catalyzes the formation of tetrahydropteroyl-L-glutamate and methionine from L-homocysteine and 5-methyltetrahydropteroyltri-L-glutamate YP_002309612.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP YP_002309613.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers YP_002309629.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose YP_002309632.1 catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA YP_002309633.1 catalyzes the formation of selenophosphate from selenide and ATP YP_002309635.1 negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis YP_002309636.1 catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs YP_002309637.1 converts L-glutamate to D-glutamate, a component of peptidoglycan YP_002309645.1 similar to superfamily SSF51998 PFL-like glycyl radical enzymes YP_002309657.1 IPR001647, Bacterial regulatory protein, TetR; IPR009057, Homeodomain-like YP_002309661.1 IPR002727, Protein of unknown function DUF47 YP_002309670.1 ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Histidine kinase A, N-terminal YP_002309671.1 Response regulator receiver:Transcriptional regulatory protein, C-terminal YP_002309677.1 ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Histidine kinase A, N-terminal YP_002309681.1 Glutathione S-transferase, N-terminal YP_002309695.1 forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme YP_002309702.1 IPR007299, Protein of unknown function DUF405; IPR007349, Protein of unknown function DUF418 YP_002309707.1 RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease YP_002309710.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine YP_002309711.1 IPR012660, Thioesterase, putative YP_002309713.1 FabB; beta-ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_002309714.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_002309716.1 FabB; beta-ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_002309720.1 similar to superfamily SSF89392 Lipoprotein localization factors LolAB YP_002309728.1 carries the fatty acid chain in fatty acid biosynthesis YP_002309733.1 catalyzes branch migration in Holliday junction intermediates YP_002309739.1 specifically modifies tRNA at position G18 YP_002309742.1 promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits YP_002309743.1 Essential for recycling GMP and indirectly, cGMP YP_002309745.1 similar to superfamily SSF53448 Nucleotide-diphospho-sugar transferases YP_002309750.1 similar to superfamily SSF56925 OMPA-like YP_002309751.1 similar to superfamily SSF56935 Porins YP_002309757.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_002309778.1 participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate YP_002309779.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_002309780.1 catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit YP_002309782.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_002309783.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_002309784.1 threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway YP_002309797.1 IPR007475, Protein of unknown function DUF526 YP_002309805.1 ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Histidine kinase A, N-terminal YP_002309806.1 Response regulator receiver:Transcriptional regulatory protein, C-terminal YP_002309818.1 HemY, N-terminal YP_002309819.1 IPR007470, Protein of unknown function DUF513, hemX YP_002309821.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis YP_002309822.1 catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP YP_002309827.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate YP_002309828.1 IPR007435, Protein of unknown function DUF484 YP_002309829.1 Phage integrase:Phage integrase, N-terminal SAM-like YP_002309844.1 Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription YP_002309846.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype YP_002309847.1 part of three member fumarate reductase enzyme complex FrdABC which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdC is the cytochrome b-556 subunit YP_002309849.1 part of three member fumarate reductase enzyme complex FrdABC which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdC is the cytochrome b-556 subunit; the catalytic subunits are similar to succinate dehydrogenase SdhAB YP_002309850.1 part of three member fumarate reductase enzyme complex FrdABC which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdC is the cytochrome b-556 subunit; the catalytic subunits are similar to succinate dehydrogenase SdhAB YP_002309852.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_002309854.1 enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation YP_002309859.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_002309868.1 IPR010668, Protein of unknown function DUF1243 YP_002309872.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity YP_002309876.1 similar to superfamily SSF53756 UDP-Glycosyltransferase/glycogen phosphorylase YP_002309879.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate YP_002309880.1 IPR010376, Protein of unknown function DUF971 YP_002309881.1 heat shock protein involved in degradation of misfolded proteins YP_002309882.1 heat shock protein involved in degradation of misfolded proteins YP_002309892.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_002309901.1 regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules YP_002309906.1 Type II and III secretion system protein:Secretin, N-terminal YP_002309920.1 IPR008985, Concanavalin A-like lectin/glucanase; IPR011050, Virulence factor, pectin lyase fold YP_002309921.1 functions in MreBCD complex in some organisms YP_002309922.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall YP_002309925.1 involved in the processing of the 5'end of 16S rRNA YP_002309936.1 IPR006839, Protein of unknown function DUF615 YP_002309938.1 IPR000379, Esterase/lipase/thioesterase YP_002309947.1 IPR010239, Conserved hypothetical protein 2001 YP_002309962.1 catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate YP_002309971.1 IPR009671, Protein of unknown function DUF1260 YP_002309974.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_002309975.1 IPR005134, Uncharacterized protein UPF0114; IPR010757, Protein of unknown function DUF1334 YP_002309977.1 transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA YP_002309982.1 similar to superfamily SSF55486 Metalloproteases ('zincins'), catalytic domain YP_002309995.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_002309996.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_002310005.1 IPR012336, Thioredoxin-like fold YP_002310007.1 similar to superfamily SSF56925 OMPA-like YP_002310026.1 similar to superfamily SSF53146 MTH1175-like YP_002310041.1 CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis YP_002310055.1 IPR009078, Ferritin/ribonucleotide reductase-like YP_002310061.1 IPR010982, Lambda repressor-like, DNA-binding YP_002310077.1 IPR000644, CBS; IPR006667, MgtE integral membrane region; IPR006668, MgtE intracellular region; IPR006669, Divalent cation transporter; IPR011002, Flagellar motor switch protein FliG-like YP_002310079.1 IPR005337, Uncharacterised P-loop ATPase protein UPF0042 YP_002310082.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen YP_002310085.1 IPR010664, Protein of unknown function DUF1239 YP_002310086.1 forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis YP_002310090.1 IPR003453, Protein of unknown function DUF140 YP_002310095.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_002310105.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_002310106.1 forms a direct contact with the tRNA during translation YP_002310108.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_002310111.1 Specifically methylates the ribose of guanosine 2251 in 23S rRNA YP_002310114.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_002310115.1 binds single-stranded DNA at the primosome assembly site YP_002310116.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_002310117.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_002310122.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer YP_002310138.1 IPR007410, Protein of unknown function DUF461 YP_002310145.1 exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA YP_002310147.1 DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate YP_002310149.1 a high throughput screen identified this enzyme as an aldehyde dehydrogenase with broad substrate specificity; converts succinylglutamate semialdehyde and NAD to succinylglutamate and NADH YP_002310151.1 ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Histidine kinase A, N-terminal YP_002310153.1 Response regulator receiver:Transcriptional regulatory protein, C-terminal YP_002310155.1 complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons YP_002310159.1 IPR010648, Protein of unknown function UPF0270 YP_002310163.1 trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell YP_002310165.1 IPR009659, Protein of unknown function DUF1249 YP_002310167.1 IPR000379, Esterase/lipase/thioesterase; IPR008886, Protein of unknown function UPF0227 YP_002310168.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_002310170.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_002310178.1 catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine YP_002310179.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity YP_002310180.1 3'-5' exoribonuclease specific for small oligoribonuclotides YP_002310184.1 IPR003442, Protein of unknown function UPF0079; IPR012298, ATPase, cell wall biosynthesis YP_002310186.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex YP_002310187.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_002310194.1 Cytochrome b/b6, N-terminal:Cytochrome b/b6, C-terminal YP_002310196.1 transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation YP_002310200.1 Helicase, C-terminal:DEAD/DEAH box helicase, N-terminal YP_002310204.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c YP_002310205.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c YP_002310207.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichia coli this protein self regulates transcription via a DNA-binding domain at the N-terminus but the proteins from this group do not and in addition appear to have a truncated C-terminal domain YP_002310214.1 IPR010985, Methionine repressor-like YP_002310218.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine YP_002310219.1 IPR007140, Protein of unknown function DUF350 YP_002310221.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme YP_002310229.1 Insulinase-like:Peptidase M16, C-terminal YP_002310230.1 Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon YP_002310236.1 IPR011462, Protein of unknown function DUF1568 YP_002310244.1 IPR010583, MltA-interacting MipA YP_002310247.1 Alanine dehydrogenase/PNT, C-terminal:Alanine dehydrogenase/PNT, N-terminal YP_002310249.1 hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide YP_002310250.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite YP_002310257.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway YP_002310259.1 IPR008526, Protein of unknown function DUF808 YP_002310274.1 IPR010710, Protein of unknown function DUF1289 YP_002310276.1 Response regulator receiver:Transcriptional regulatory protein, C-terminal YP_002310297.1 IPR000612, Protein of unknown function UPF0057 YP_002310298.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_002310301.1 IPR007838, Protein of unknown function DUF710 YP_002310303.1 IPR005356, Protein of unknown function UPF0149; IPR011978, YgfB and YecA YP_002310306.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein YP_002310307.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor YP_002310308.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine YP_002310324.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone; in S. meliloti it is known to be involved specifically with K+ transport YP_002310327.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone YP_002310330.1 subunit B of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_002310340.1 similar to superfamily SSF51730 FAD-linked oxidoreductase YP_002310356.1 IPR001466, Beta-lactamase; IPR012338, Penicillin-binding protein, transpeptidase fold YP_002310370.1 Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively; pyrimidine-specific YP_002310382.1 one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity YP_002310386.1 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole YP_002310389.1 catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation YP_002310390.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide YP_002310391.1 IPR000717, Proteasome component region PCI YP_002310394.1 Helicase, C-terminal:Type III restriction enzyme, res subunit YP_002310446.1 IPR010323, Protein of unknown function DUF924, bacterial YP_002310455.1 IPR010239, Conserved hypothetical protein 2001 YP_002310456.1 response regulator in two-component regulatory system with TorS; involved in regulation of trimethylamine N-oxide reductase genes YP_002310457.1 periplasmic sensory protein associated with the TorRS two-component regulatory system YP_002310458.1 Response regulator receiver:ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Histidine kinase A, N-terminal:Hpt YP_002310466.1 detoxifies nitric oxide using NADH YP_002310467.1 catalyzes the reduction of the rubredoxin moiety of nitric oxide reductase YP_002310478.1 Glutathione S-transferase, N-terminal YP_002310484.1 IPR005625, PepSY-associated TM helix YP_002310499.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA YP_002310500.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_002310501.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX YP_002310504.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell YP_002310513.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway YP_002310514.1 Catalyzes the conversion of carbamoyl phosphate and l-aspartate to yield orthophosphate and n-carbamoyl-l-aspartate YP_002310517.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein YP_002310525.1 IPR008537, Protein of unknown function DUF819 YP_002310526.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis YP_002310535.1 putative nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription YP_002310542.1 IPR001867, Transcriptional regulatory protein, C-terminal YP_002310549.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2 YP_002310550.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm YP_002310551.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm YP_002310552.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm YP_002310553.1 Part of the NQR complex which catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm YP_002310554.1 Part of the NQR complex which consists of NqrA, NqrB, NqrC, NqrD, NqrE and NqrF; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm; NqrE is probably involved in the second step, the conversion of ubisemiquinone to ubiquinol. YP_002310555.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm YP_002310557.1 IPR007495, Protein of unknown function DUF539 YP_002310562.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function YP_002310564.1 Peptidase M17, cytosol aminopeptidase, C-terminal YP_002310575.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis YP_002310576.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway YP_002310579.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_002310580.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_002310583.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_002310584.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_002310585.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity YP_002310588.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane YP_002310590.1 IPR001890, Protein of unknown function UPF0044 YP_002310591.1 Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit YP_002310594.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_002310595.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate YP_002310597.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins YP_002310598.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_002310599.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_002310600.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_002310601.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs YP_002310602.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_002310605.1 lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing YP_002310606.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein YP_002310610.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate YP_002310611.1 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate YP_002310613.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate YP_002310618.1 ATP-binding region, ATPase-like:Histidine kinase A, N-terminal YP_002310623.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_002310633.1 similar to superfamily SSF56925 OMPA-like YP_002310643.1 Required for efficient pilin antigenic variation YP_002310645.1 Response regulator receiver:Transcriptional regulatory protein, C-terminal YP_002310654.1 IPR009998, YfaZ YP_002310662.1 HMMTigr TIGR02453 TIGR02453: conserved hypothetical protein T YP_002310663.1 IPR003791, Protein of unknown function DUF188 YP_002310667.1 IPR005115, Protein of unknown function UPF0126 YP_002310689.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain YP_002310690.1 Glycoside hydrolase, family 13, N-terminal:Alpha amylase, catalytic region YP_002310692.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate YP_002310694.1 IPR002790, Protein of unknown function DUF88 YP_002310697.1 IPR001129, Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG) YP_002310699.1 fragment YP_002310706.1 IPR002656, Acyltransferase 3 YP_002310709.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence YP_002310711.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_002310712.1 IPR003796, Protein of unknown function DUF193; IPR005144, ATP-cone YP_002310714.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine YP_002310716.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_002310717.1 Regulates rRNA biosynthesis by transcriptional antitermination YP_002310724.1 IPR007338, Protein of unknown function DUF416 YP_002310725.1 part of the two-component regulatory system with UvrY; involved in the regulation of carbon metabolism via the csrA/csrB regulatory system YP_002310726.1 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S] YP_002310728.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era YP_002310729.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_002310730.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_002310732.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers YP_002310733.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate YP_002310735.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate YP_002310739.1 This protein performs the mismatch recognition step during the DNA repair process YP_002310740.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_002310741.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002310742.1 affects carbohydrate metabolism; has regulatory role in many processes YP_002310745.1 IPR002881, Protein of unknown function DUF58 YP_002310753.1 catalyzes the formation of pyruvate from oxaloacetate YP_002310763.1 Insulinase-like:Peptidase M16, C-terminal YP_002310764.1 involved in the first step of glutathione biosynthesis YP_002310791.1 NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds YP_002310800.1 converts protoheme IX and farnesyl diphosphate to heme O YP_002310802.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_002310804.1 IPR005346, Protein of unknown function UPF0125 YP_002310806.1 Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle YP_002310809.1 similar to superfamily SSF54427 NTF2-like YP_002310810.1 IPR010384, Protein of unknown function DUF980 YP_002310818.1 Metallophosphoesterase:5'-Nucleotidase, C-terminal YP_002310821.1 IPR004383, Conserved hypothetical protein 48 YP_002310824.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis YP_002310825.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_002310827.1 with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis YP_002310828.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_002310835.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_002310836.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate YP_002310837.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_002310839.1 YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function YP_002310840.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_002310844.1 IPR011724, Cyd operon protein YbgT YP_002310850.1 similar to superfamily SSF56935 Porins YP_002310851.1 similar to superfamily SSF54626 Chalcone isomerase YP_002310864.1 IPR007293, Protein of unknown function DUF400 YP_002310867.1 required for the assembly of the flagellar basal body P-ring YP_002310870.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod YP_002310871.1 with FlgF and B makes up the proximal portion of the flagellar basal body rod YP_002310872.1 acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production YP_002310873.1 the hook connects flagellar basal body to the flagellar filament YP_002310874.1 FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod YP_002310875.1 makes up the distal portion of the flagellar basal body rod YP_002310876.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod YP_002310877.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum YP_002310878.1 Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space YP_002310880.1 with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes. YP_002310882.1 Flagellin, C-terminal:Flagellin, N-terminal YP_002310883.1 Flagellin, C-terminal:Flagellin, N-terminal YP_002310885.1 Flagellar hook-associated protein 2, N-terminal:Flagellar hook-associated 2, C-terminal:Flagellin hook IN YP_002310887.1 flagellin specific chaperone YP_002310889.1 ATP-binding region, ATPase-like:Histidine kinase A, N-terminal YP_002310892.1 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod YP_002310893.1 One of three proteins involved in switching the direction of the flagellar rotation YP_002310895.1 involved in type III protein export during flagellum assembly YP_002310898.1 interacts with the cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring YP_002310899.1 with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation YP_002310900.1 One of three proteins involved in switching the direction of the flagellar rotation YP_002310902.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus YP_002310904.1 FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus YP_002310905.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export YP_002310906.1 membrane protein involved in the flagellar export apparatus YP_002310907.1 positive regulator of class III flagellar genes YP_002310909.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes YP_002310913.1 regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins YP_002310952.1 similar to superfamily SSF52540 P-loop containing nucleoside triphosphate hydrolases YP_002310956.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP YP_002310967.1 IPR011462, Protein of unknown function DUF1568 YP_002310986.1 Phosphoesterase PHP, N-terminal:PHP, C-terminal YP_002310990.1 Glycoside hydrolase, family 3, N-terminal:Glycoside hydrolase, family 3, C-terminal YP_002311002.1 Glycoside hydrolase, family 3, N-terminal:Glycoside hydrolase, family 3, C-terminal YP_002311005.1 catalyzes phosphorylation of fructose; cytosolic enzyme YP_002311006.1 IPR003848, Protein of unknown function DUF218 YP_002311009.1 IPR007607, Protein of unknown function DUF583 YP_002311013.1 phenylalanine 4-hydroxylase; phenylalanine 4-hydroxylase; catalyzes the formation of 4a-hydroxytetrahydrobiopterin and tyrosine from phenylalanine and tetrahydrobiopterin YP_002311014.1 4-alpha-hydroxytetrahydrobiopterin dehydratase activity; catalyzes the formation of (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7, 8-dihydro-6H-pterin from (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7, 8-tetrahydro-4a-hydroxypterin; functions in recycling tetrahydrobiopterin (BH4) in phenylalanine hydroxylase reaction YP_002311023.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_002311027.1 Helicase, C-terminal:DEAD/DEAH box helicase, N-terminal YP_002311031.1 involved in the import of serine and threonine coupled with the import of sodium YP_002311035.1 IPR007431, Protein of unknown function DUF479 YP_002311037.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step YP_002311038.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) YP_002311039.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex YP_002311040.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane YP_002311041.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_002311043.1 IPR001876, Zn-finger, Ran-binding YP_002311045.1 Siroheme synthase, N-terminal component, putative YP_002311054.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis YP_002311057.1 J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins YP_002311058.1 involved in the maturation of iron-sulfur cluster-containing proteins YP_002311061.1 IPR007479, Protein of unknown function DUF528 YP_002311063.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate YP_002311071.1 IPR007401, Protein of unknown function DUF454 YP_002311074.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis YP_002311076.1 IPR004401, Conserved hypothetical protein 103 YP_002311082.1 IPR002881, Protein of unknown function DUF58 YP_002311089.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_002311090.1 molecular chaperone YP_002311092.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_002311093.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic YP_002311098.1 catalyzes the hydrolysis of 2-N-succinylarginine into 2-N-succinylornithine, ammonia and carbon dioxide in arginine degradation YP_002311101.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity YP_002311103.1 LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation YP_002311105.1 hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides YP_002311107.1 IPR008886, Protein of unknown function UPF0227 YP_002311108.1 catalyzes the hydrolysis of acylphosphate YP_002311114.1 IPR003838, Protein of unknown function DUF214; IPR011925, Lipoprotein releasing system, transmembrane protein, LolC/E family YP_002311117.1 IPR003838, Protein of unknown function DUF214; IPR011925, Lipoprotein releasing system, transmembrane protein, LolC/E family YP_002311121.1 IPR000594, UBA/THIF-type NAD/FAD binding fold; IPR003776, Protein of unknown function DUF181; IPR009036, Molybdenum cofactor biosynthesis YP_002311125.1 similar to superfamily SSF53187 Zn-dependent exopeptidases YP_002311127.1 IPR010393, Protein of unknown function DUF991 YP_002311133.1 IPR008314, Uncharacterised conserved protein UCP029143 YP_002311141.1 IPR011435, Protein of unknown function DUF1538 YP_002311142.1 IPR011435, Protein of unknown function DUF1538 YP_002311160.1 functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP YP_002311167.1 similar to superfamily SSF56935 Porins YP_002311168.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate YP_002311169.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_002311170.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate YP_002311174.1 Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A) YP_002311182.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA YP_002311187.1 functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase YP_002311188.1 Helicase, C-terminal:Type III restriction enzyme, res subunit:DEAD/DEAH box helicase, N-terminal YP_002311191.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA YP_002311198.1 tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate YP_002311200.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_002311201.1 FAD linked oxidase, C-terminal:FAD linked oxidase, N-terminal YP_002311210.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_002311211.1 HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis YP_002311212.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_002311219.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA YP_002311221.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_002311222.1 Arginine-tRNA-protein transferase, N-terminal:Arginine-tRNA-protein transferase, C-terminal YP_002311223.1 leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys YP_002311230.1 Glutathione S-transferase, N-terminal YP_002311234.1 IPR002810, Protein of unknown function DUF107 YP_002311240.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity YP_002311241.1 IPR009476, Protein of unknown function DUF1097 YP_002311244.1 IPR008972, Cupredoxin YP_002311247.1 removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction YP_002311248.1 unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity YP_002311249.1 Involved in cell division; probably involved in intracellular septation YP_002311263.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis YP_002311264.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_002311265.1 monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate YP_002311266.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate YP_002311267.1 TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity YP_002311268.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine YP_002311269.1 Phosphoesterase PHP, N-terminal:PHP, C-terminal YP_002311272.1 IPR003768, Prokaryotic chromosome segregation and condensation protein ScpA YP_002311278.1 SohB; periplasmic protein; member of the peptidase S49 family YP_002311280.1 IPR012282, Cytochrome c region YP_002311286.1 IPR003838, Protein of unknown function DUF214 YP_002311288.1 IPR002549, Protein of unknown function UPF0118 YP_002311292.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate YP_002311293.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA YP_002311294.1 IPR007334, Protein of unknown function DUF412 YP_002311295.1 activates pyruvate formate-lyase 1 under anaerobic conditions YP_002311308.1 IPR008960, Carbohydrate-binding family 9, cellobiose dehydrogenase cytochrome YP_002311309.1 putative role in sulfur assimilation YP_002311311.1 ZipA, C-terminal FtsZ-binding region YP_002311322.1 IPR011644, Heme NO binding YP_002311324.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; in Pseudomonas this protein is involved in quinolone signal biosynthesis YP_002311331.1 Peptidase M24:Peptidase M24B, X-Pro dipeptidase/aminopeptidase N-terminal YP_002311333.1 Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate YP_002311336.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_002311337.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon YP_002311338.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis YP_002311339.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_002311340.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_002311342.1 binds directly to 23S ribosomal RNA YP_002311343.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_002311344.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_002311345.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_002311346.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_002311347.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_002311348.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_002311349.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_002311350.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_002311351.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_002311354.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_002311355.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_002311356.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_002311357.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_002311358.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_002311359.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_002311360.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_002311361.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_002311362.1 one of the stabilizing components for the large ribosomal subunit YP_002311363.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_002311364.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_002311365.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_002311366.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_002311367.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif YP_002311368.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_002311369.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_002311370.1 binds 5S rRNA along with protein L5 and L25 YP_002311371.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_002311372.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_002311373.1 late assembly protein YP_002311374.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_002311375.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif YP_002311376.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_002311377.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_002311378.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_002311379.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_002311380.1 is a component of the macrolide binding site in the peptidyl transferase center YP_002311382.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane YP_002311386.1 ATP-binding protein; required for proper cytochrome c maturation YP_002311395.1 IPR010835, Protein of unknown function DUF1439 YP_002311396.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate YP_002311397.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis YP_002311398.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate YP_002311399.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate YP_002311400.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation YP_002311401.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming YP_002311402.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_002311409.1 type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis YP_002311410.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis YP_002311416.1 similar to superfamily hydrolase, subfamily IA, variant 3:HAD-similar to superfamily hydrolase, subfamily IA, variant 1 YP_002311417.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002311422.1 IPR003509, Protein of unknown function UPF0102 YP_002311425.1 IPR000878, Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; IPR008189, Protein of unknown function UPF0011 YP_002311442.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome YP_002311449.1 IPR011669, Protein of unknown function DUF1611 YP_002311456.1 IPR008969, Carboxypeptidase regulatory region; IPR008979, Galactose-binding like YP_002311461.1 similar to superfamily SSF56925 OMPA-like YP_002311464.1 Transcriptional regulatory protein, C-terminal YP_002311470.1 IPR010652, Protein of unknown function DUF1232 YP_002311494.1 similar to superfamily SSF56935 Porins YP_002311498.1 IPR008207, Hpt YP_002311512.1 catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages YP_002311514.1 IPR009491, Protein of unknown function DUF1107 YP_002311533.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs YP_002311534.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_002311535.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer YP_002311537.1 FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly YP_002311538.1 catalyzes the formation of dUMP from dUTP YP_002311540.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase YP_002311541.1 required for 70S ribosome assembly YP_002311542.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_002311544.1 catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis YP_002311550.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis YP_002311551.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis YP_002311552.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_002311553.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D YP_002311555.1 similar to superfamily SSF54427 NTF2-like YP_002311558.1 MraZ; UPF0040; crystal structure shows similarity to AbrB YP_002311562.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate YP_002311564.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_002311565.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_002311567.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_002311568.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_002311571.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_002311572.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis YP_002311575.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_002311583.1 IPR005123, 2OG-Fe(II) oxygenase; IPR006620, Prolyl 4-hydroxylase, alpha subunit YP_002311585.1 Response regulator receiver:Transcriptional regulatory protein, C-terminal YP_002311598.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers YP_002311604.1 IPR009857, Protein of unknown function DUF1414 YP_002311606.1 similar to superfamily SSF82220 Tp47 lipoprotein, N-terminal domain YP_002311611.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate YP_002311612.1 IPR005651, Protein of unknown function DUF343 YP_002311622.1 Activates fatty acids by binding to coenzyme A YP_002311624.1 works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell YP_002311626.1 blocks the formation of polar Z-ring septums YP_002311627.1 IPR007840, Protein of unknown function DUF709 YP_002311629.1 IPR008228, Uncharacterised conserved protein UCP006173 YP_002311637.1 similar to subfamily 1 YP_002311644.1 functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA YP_002311653.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_002311662.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine YP_002311668.1 in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center YP_002311676.1 similar to superfamily SSF55486 Metalloproteases ('zincins'), catalytic domain YP_002311679.1 IPR008503, Protein of unknown function DUF785 YP_002311683.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_002311684.1 IPR002876, Protein of unknown function DUF28 YP_002311685.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity YP_002311686.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_002311687.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_002311691.1 IPR008962, PapD-like YP_002311697.1 in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase YP_002311698.1 part of membrane-bound complex hought to be involved in electron transport to nitrogen YP_002311699.1 RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents YP_002311700.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen YP_002311701.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen YP_002311704.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_002311712.1 similar to superfamily SSF54427 NTF2-like YP_002311713.1 Smr protein/MutS2 C-terminal YP_002311716.1 functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA YP_002311719.1 Represses the expression of the zwf, eda, glp and gap YP_002311720.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_002311722.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate YP_002311723.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate YP_002311724.1 serine protease inhibitor, inhibits trypsin and other proteases YP_002311732.1 IPR002881, Protein of unknown function DUF58 YP_002311748.1 IPR005532, Protein of unknown function DUF323 YP_002311758.1 catalyzes the formation of pyruvate and succinate from 2-methylisocitrate YP_002311760.1 Catalyzes the conversion of citrate to isocitrate YP_002311761.1 IPR007400, Protein of unknown function DUF453 YP_002311768.1 IPR005358, Protein of unknown function UPF0153 YP_002311774.1 IPR003776, Protein of unknown function DUF181 YP_002311788.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine YP_002311792.1 catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002311795.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_002311799.1 IPR009749, Protein of unknown function DUF1315 YP_002311800.1 converts asparagine to aspartate and ammonia YP_002311806.1 B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA YP_002311807.1 Catalyzes the rate-limiting step in dNTP synthesis YP_002311809.1 Involved in ubiquinone biosynthesis YP_002311813.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine YP_002311814.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate YP_002311816.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_002311817.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP YP_002311818.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_002311819.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_002311822.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase YP_002311829.1 similar to superfamily SSF56925 OMPA-like YP_002311834.1 catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome YP_002311843.1 IPR007329, FMN-binding YP_002311847.1 Metallophosphoesterase:5'-Nucleotidase, C-terminal YP_002311851.1 IPR004119, Protein of unknown function DUF227; IPR011009, Protein kinase-like YP_002311863.1 catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; involved in growth under gluconeogenic conditions and in glycolytic activity at high ATP concentrations in Corynebacterium; NAD and NADP dependent YP_002311872.1 uncharacterized member of the major facilitator superfamily (MFS) YP_002311877.1 catalyzes the hydrolysis of pyrophosphate to phosphate YP_002311888.1 IPR008766, Bacteriophage replication gene A YP_002311898.1 CcoN; FixN YP_002311906.1 Global transcription factor that controls the expression of over 100 target genes in response to anoxia YP_002311907.1 with UspC and UspD is involved in resistance to UV irradiation YP_002311908.1 similar to superfamily implicated in cell cycle control, putative; TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs YP_002311911.1 IPR002882, Protein of unknown function UPF0052 and CofD; IPR010119, Conserved hypothetical protein CofD YP_002311912.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate YP_002311913.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002311914.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling YP_002311918.1 mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system YP_002311920.1 Response regulator receiver:Transcriptional regulatory protein, C-terminal YP_002311921.1 IPR010281, Protein of unknown function DUF885, bacterial YP_002311924.1 catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol) YP_002311925.1 similar to superfamily SSF52540 P-loop containing nucleoside triphosphate hydrolases YP_002311927.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate YP_002311931.1 catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism YP_002311933.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate YP_002311934.1 negative modulator of the initiation of chromosome replication YP_002311941.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_002311942.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor YP_002311944.1 dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate YP_002311947.1 catalyzes the formation of malate from glyoxylate and acetyl-CoA YP_002311951.1 Catalyzes the first step in the glyoxalate cycle, which converts lipids to carbohydrates YP_002311959.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002311961.1 Twin-arginine translocation pathway signal YP_002311970.1 AIR synthase-like protein:AIR synthase-like protein, C-terminal YP_002311985.1 IPR000917, Sulfatase YP_002311988.1 IPR001602, Protein of unknown function UPF0047 YP_002311997.1 Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle YP_002312015.1 functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose YP_002312017.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. YP_002312023.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS YP_002312032.1 Phage integrase:Phage integrase, N-terminal SAM-like YP_002312046.1 IPR011462, Protein of unknown function DUF1568 YP_002312047.1 IPR003961, Fibronectin, type III; IPR008957, Fibronectin, type III-like fold YP_002312052.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_002312056.1 specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport YP_002312057.1 IPR002549, Protein of unknown function UPF0118 YP_002312062.1 IPR000601, PKD YP_002312065.1 controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP YP_002312074.1 in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme YP_002312075.1 in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ YP_002312076.1 IPR003798, Protein of unknown function DUF195 YP_002312080.1 IPR002881, Protein of unknown function DUF58 YP_002312085.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_002312088.1 periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC YP_002312097.1 IPR007452, Protein of unknown function DUF490 YP_002312100.1 involved in regulation of intracellular pH under alkaline conditions YP_002312101.1 disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein YP_002312105.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_002312106.1 IPR009045, Hedgehog signalling region, N-terminal; IPR010275, Protein of unknown function DUF882, bacterial YP_002312107.1 IPR009070, Peptidoglycan binding-like YP_002312110.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_002312115.1 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP YP_002312117.1 Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth YP_002312119.1 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA YP_002312122.1 IPR009809, Protein of unknown function DUF1379 YP_002312123.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors YP_002312131.1 Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3 YP_002312132.1 affects solute and DNA transport through an unknown mechanism YP_002312140.1 in Escherichia coli this enzyme specifically methylates C1407 of the 16S rRNA YP_002312145.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) YP_002312146.1 IPR003770, Aminodeoxychorismate lyase YP_002312149.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor YP_002312151.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_002312152.1 IPR002678, Protein of unknown function DUF34 YP_002312158.1 catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides YP_002312167.1 IPR011011, FYVE/PHD zinc finger YP_002312172.1 IPR005185, Protein of unknown function DUF307 YP_002312186.1 IPR007434, Protein of unknown function DUF482 YP_002312189.1 IPR009057, Homeodomain-like YP_002312196.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm YP_002312197.1 Part of the NQR complex which consists of NqrA, NqrB, NqrC, NqrD, NqrE and NqrF; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm; NqrE is probably involved in the second step, the conversion of ubisemiquinone to ubiquinol. YP_002312198.1 Part of the NQR complex which catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm YP_002312199.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm YP_002312201.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm YP_002312202.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm YP_002312221.1 IPR010824, Protein of unknown function DUF1425 YP_002312234.1 Uroporphyrin-III C-methyltransferase, C-terminal YP_002312237.1 putative metalloprotease YP_002312247.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_002312249.1 similar to superfamily SSF52540 P-loop containing nucleoside triphosphate hydrolases YP_002312250.1 Modulates the activities of several enzymes which are inactive in their acetylated form YP_002312251.1 negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer YP_002312259.1 catalyzes the interconversion of succinyl-CoA and succinate YP_002312261.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide YP_002312262.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase YP_002312267.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH YP_002312279.1 periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate YP_002312285.1 manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily YP_002312289.1 Acyl-CoA dehydrogenase, C-terminal YP_002312294.1 IPR008309, Uncharacterised conserved protein UCP025560; IPR010985, Methionine repressor-like YP_002312307.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors YP_002312308.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_002312309.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_002312310.1 catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate YP_002312311.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide YP_002312312.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide YP_002312313.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase YP_002312314.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis YP_002312316.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_002312317.1 Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA YP_002312318.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_002312319.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_002312320.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_002312323.1 IPR008503, Protein of unknown function DUF785; IPR009007, Peptidase aspartic, catalytic YP_002312325.1 IPR007372, YceI YP_002312327.1 catalyzes the formation of putrescine from agmatine YP_002312329.1 catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis YP_002312332.1 IPR007432, Protein of unknown function DUF480 YP_002312339.1 methylates the guanosine in position 745 of 23S rRNA; required for translation and cell growth YP_002312341.1 Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates YP_002312342.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis YP_002312348.1 carries the fatty acid chain in fatty acid biosynthesis YP_002312352.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs YP_002312353.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY YP_002312354.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_002312355.1 IPR003772, Protein of unknown function DUF177 YP_002312362.1 this fusion consists of methionine sulfoxide B reductase at the N-terminus and A at the C-terminus; A and B are stereospecific enzymes that recognize the damaged produces of oxidative stress, S and R epimers of methionine sulfoxide, respectively; a fusion protein of these enzymes with thioredoxin provides protection against oxidative stress in Neisseria gonorrhoeae YP_002312364.1 essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc) YP_002312387.1 catalyzes the formation of a phosphodiester at the site of a single-strand break in duplex DNA YP_002312390.1 similar to superfamily SSF56925 OMPA-like YP_002312396.1 Response regulator receiver:Transcriptional regulatory protein, C-terminal YP_002312397.1 ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Histidine kinase A, N-terminal YP_002312398.1 catalyzes the formation of L-homocysteine from cystathionine YP_002312401.1 similar to superfamily SSF54427 NTF2-like YP_002312407.1 cation efflux system protein YP_002312410.1 decatenates replicating daughter chromosomes YP_002312411.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_002312415.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_002312421.1 IPR006076, FAD dependent oxidoreductase YP_002312427.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_002312428.1 involved in methylation of ribosomal protein L3 YP_002312436.1 multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate YP_002312437.1 FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth YP_002312439.1 IPR002881, Protein of unknown function DUF58 YP_002312445.1 Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription YP_002312449.1 IPR007497, Protein of unknown function DUF541 YP_002312454.1 Peptidase S8 and S53, subtilisin, kexin, sedolisin:Proprotein convertase, P:Protease-associated PA:Peptidase, archaeal and bacterial C-terminal:Proteinase inhibitor I9, subtilisin propeptide YP_002312457.1 catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate YP_002312460.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates YP_002312476.1 Response regulator receiver:Transcriptional regulatory protein, C-terminal YP_002312477.1 ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Histidine kinase A, N-terminal YP_002312479.1 transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis YP_002312489.1 IPR002781, Protein of unknown function DUF81 YP_002312491.1 IPR000719, Protein kinase; IPR011009, Protein kinase-like YP_002312492.1 similar to superfamily SSF89946 Hypothetical protein VC0424 YP_002312496.1 IPR010281, Protein of unknown function DUF885, bacterial YP_002312499.1 TonB, C-terminal YP_002312506.1 Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C YP_002312507.1 helicase involved in DNA repair and perhaps also replication YP_002312508.1 IPR002781, Protein of unknown function DUF81 YP_002312522.1 similar to superfamily SSF56731 DNA primase core T YP_002312528.1 IPR001736, Phospholipase D/Transphosphatidylase YP_002312539.1 acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding YP_002312545.1 Oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal YP_002312547.1 enzyme from Treponema denticola exhibits NADH-dependent trans-2-enoyl-CoA reductase activity YP_002312551.1 binds and unfolds substrates as part of the ClpXP protease YP_002312552.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_002312553.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_002312554.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate YP_002312555.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_002312557.1 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine YP_002312560.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002312579.1 Transcriptional regulatory protein, C-terminal YP_002312597.1 Glutathione S-transferase, C-terminal YP_002312606.1 TonB, C-terminal YP_002312608.1 3'-5' exonuclease of DNA polymerase III YP_002312615.1 IPR011038, Calycin_like YP_002312623.1 Catalyzes the specific recognition and activation of amino acids during peptide synthesis YP_002312625.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs YP_002312626.1 similar to superfamily SSF53335 S-adenosyl-L-methionine-dependent methyltransferases YP_002312629.1 IPR010710, Protein of unknown function DUF1289 YP_002312632.1 regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon YP_002312633.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_002312644.1 IPR009858, Protein of unknown function DUF1415 YP_002312649.1 similar to superfamily SSF56925 OMPA-like YP_002312651.1 similar to superfamily SSF55486 Metalloproteases ('zincins'), catalytic domain YP_002312653.1 IPR000498, OmpA-like transmembrane region YP_002312669.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_002312672.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_002312680.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis YP_002312683.1 receptor for colicin S4 YP_002312684.1 IPR009267, Protein of unknown function DUF925, bacterial YP_002312697.1 Glycoside hydrolase, family 13, N-terminal:Alpha amylase, catalytic region YP_002312699.1 IPR007114, Major facilitator similar to superfamily YP_002312708.1 functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA YP_002312714.1 IPR008775, Phytanoyl-CoA dioxygenase YP_002312718.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate YP_002312731.1 Biotin/lipoyl attachment:Carbamoyl-phosphate synthase L chain, ATP-binding:Carbamoyl-phosphate synthetase large chain, N-terminal:Biotin carboxylase, C-terminal YP_002312751.1 catalyzes the formation of thymidine 5'-phosphate from thymidine YP_002312760.1 IPR001378, Protein of unknown function UPF0066 YP_002312764.1 IPR008523, Protein of unknown function DUF805 YP_002312765.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_002312773.1 similar to superfamily SSF56935 Porins YP_002312774.1 Response regulator receiver:ATP-binding region, ATPase-like:Histidine kinase A, N-terminal YP_002312787.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase YP_002312788.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_002312789.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM YP_002312790.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis YP_002312791.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP YP_002312792.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis YP_002312796.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate YP_002312799.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_002312800.1 Catalyzes the phosphorylation of UMP to UDP YP_002312801.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_002312802.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_002312803.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn YP_002312804.1 catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein YP_002312805.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway YP_002312808.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_002312810.1 IPR007384, Protein of unknown function DUF446 YP_002312821.1 putative SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function YP_002312822.1 catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis YP_002312843.1 Helicase, C-terminal:DEAD/DEAH box helicase, N-terminal YP_002312844.1 similar to superfamily SSF48452 TPR-like YP_002312863.1 similar to superfamily SSF56935 Porins YP_002312866.1 catalyzes the release of the N-terminal amino acid from a tripeptide YP_002312877.1 involved in start site selection during the initiation of translation YP_002312878.1 IPR003774, Protein of unknown function DUF179 YP_002312879.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function YP_002312884.1 catalyzes the formation of 2-oxoglutarate from isocitrate YP_002312885.1 similar to superfamily SSF53335 S-adenosyl-L-methionine-dependent methyltransferases YP_002312887.1 IPR006696, Protein of unknown function DUF423 YP_002312889.1 Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence YP_002312891.1 Required for the synthesis of the thiazole moiety YP_002312892.1 with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; Vibrio parahaemolyticus protein is associated with the polar flagella YP_002312893.1 Homologous to MotA in E. coli and Salmonella. With PomB forms the ion channels that couple flagellar rotation to sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine. YP_002312896.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_002312904.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor YP_002312905.1 catalyzes the phosphorylation of NAD to NADP YP_002312910.1 4Fe-4S ferredoxin, iron-sulfur binding:FAD linked oxidase, C-terminal:FAD linked oxidase, N-terminal YP_002312911.1 IPR004017, Protein of unknown function DUF224, cysteine-rich region YP_002312914.1 TonB, C-terminal YP_002312916.1 similar to superfamily SSF52540 P-loop containing nucleoside triphosphate hydrolases YP_002312921.1 TonB, C-terminal YP_002312922.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription YP_002312927.1 Helicase, C-terminal:DEAD/DEAH box helicase, N-terminal YP_002312934.1 IPR007049, Carbohydrate-selective porin OprB YP_002312935.1 IPR008994, Nucleic acid-binding, OB-fold YP_002312942.1 has 3'-5' exonuclease activity that preferentially acts on ssDNA; also 3'-phosphodiesterase activity at sites with 3' incised apurinic/apyrimidinic sites; can remove 3' phosphoglycolate groups YP_002312947.1 IPR001608, Alanine racemase, N-terminal; IPR011078, Protein of unknown function UPF0001 YP_002312949.1 IPR003425, Protein of unknown function YGGT YP_002312952.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine YP_002312954.1 IPR010281, Protein of unknown function DUF885, bacterial YP_002312957.1 catalyzes the formation of glutamate from glutamine YP_002312958.1 IPR007416, Protein of unknown function DUF469 YP_002312959.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine YP_002312961.1 IPR007457, Fe(II) trafficking protein YggX YP_002312979.1 IPR002781, Protein of unknown function DUF81 YP_002312995.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway YP_002312997.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_002312998.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme YP_002313002.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_002313005.1 IPR005583, Protein of unknown function DUF328 YP_002313011.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_002313017.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_002313018.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate YP_002313019.1 multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways YP_002313031.1 catalyzes the reduction of hydroxylamine to ammonia and water YP_002313032.1 catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis YP_002313033.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive YP_002313034.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_002313035.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_002313036.1 Essential for efficient processing of 16S rRNA YP_002313037.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_002313038.1 with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins YP_002313041.1 IPR009305, Protein of unknown function DUF962 YP_002313044.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids YP_002313045.1 involved in the de novo synthesis of pyridoxine (Vitamin B6) YP_002313047.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_002313048.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity YP_002313050.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_002313054.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response YP_002313055.1 catalyzes the formation of oxaloacetate from L-aspartate YP_002313057.1 Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC YP_002313059.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH YP_002313060.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived YP_002313061.1 IPR002781, Protein of unknown function DUF81 YP_002313063.1 hydrolyzes diadenosine polyphosphate YP_002313064.1 MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair YP_002313069.1 catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate YP_002313070.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate YP_002313075.1 HTH-type; bet1; Repressor involved in choline regulation of the bet genes YP_002313076.1 catalyzes the formation of betaine from betaine aldehyde YP_002313077.1 catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine YP_002313083.1 IPR011056, Peptidase S24 and S26, C-terminal region YP_002313092.1 IPR001387, Helix-turn-helix motif; IPR010982, Lambda repressor-like, DNA-binding YP_002313098.1 IPR005115, Protein of unknown function UPF0126 YP_002313099.1 similar to superfamily SSF54427 NTF2-like YP_002313102.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) YP_002313104.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling YP_002313105.1 Transcriptional regulatory protein, C-terminal YP_002313110.1 porin involved in osmoregulation allowing water to move into and out of the cell in response to osmotic pressure YP_002313113.1 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors YP_002313123.1 catalyzes the formation of L-proline from L-ornithine YP_002313134.1 Glutathione S-transferase, N-terminal:Glutathione S-transferase, C-terminal YP_002313138.1 IPR009921, Protein of unknown function DUF1456 YP_002313139.1 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate YP_002313141.1 similar to superfamily SSF51294 Hedgehog/intein (Hint) domain YP_002313146.1 IPR009923, Protein of unknown function DUF1458 YP_002313155.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_002313156.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins YP_002313158.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis YP_002313160.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_002313161.1 Transcriptional regulatory protein, C-terminal YP_002313165.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_002313166.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_002313169.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_002313171.1 IPR002036, Protein of unknown function UPF0054 YP_002313173.1 Transfers the fatty acyl group on membrane lipoproteins YP_002313176.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_002313182.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA YP_002313188.1 IPR007454, Protein of unknown function DUF493 YP_002313189.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein YP_002313190.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_002313198.1 IPR003730, Protein of unknown function DUF152 YP_002313200.1 similar to superfamily SSF48452 TPR-like YP_002313207.1 TonB, C-terminal YP_002313208.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive YP_002313215.1 catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552 YP_002313219.1 IPR008249, Uncharacterised conserved protein UCP006287 YP_002313233.1 IPR010413, Protein of unknown function DUF1008 YP_002313236.1 TonB, C-terminal YP_002313241.1 with HmuTU is involved in the transport of hemin YP_002313242.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_002313243.1 IPR012338, Penicillin-binding protein, transpeptidase fold YP_002313247.1 NapC/NirT cytochrome c, N-terminal YP_002313249.1 TorD; involved in the biogenesis of torA; acts on torA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor YP_002313267.1 Transcriptional regulatory protein, C-terminal YP_002313270.1 IPR003846, Protein of unknown function UPF0061 YP_002313278.1 TonB, C-terminal YP_002313284.1 IPR005589, Protein of unknown function DUF331 YP_002313286.1 IPR002059, Cold-shock protein, DNA-binding; IPR008994, Nucleic acid-binding, OB-fold; IPR011129, Cold shock protein YP_002313290.1 Pirin, N-terminal:Pirin, C-terminal YP_002313305.1 IPR011701, Major facilitator similar to superfamily MFS_1 YP_002313310.1 converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis YP_002313312.1 may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ YP_002313313.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP YP_002313314.1 Uroporphyrin-III C-methyltransferase, C-terminal YP_002313316.1 IPR012338, Penicillin-binding protein, transpeptidase fold YP_002313328.1 IPR011223, Protein of unknown function UCP028770 YP_002313329.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis YP_002313332.1 functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system YP_002313337.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate) YP_002313338.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_002313340.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP YP_002313345.1 IPR010619, Protein of unknown function DUF1212 YP_002313346.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_002313347.1 involved in the peptidyltransferase reaction during translation YP_002313350.1 oxidizes malate to oxaloacetate YP_002313351.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes YP_002313358.1 Glutathione S-transferase, N-terminal YP_002313378.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis YP_002313383.1 IPR012548, Protein of unknown function DUF1704; IPR012656, Conserved hypothetical protein QEGLA YP_002313384.1 The second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione YP_002313394.1 CcoN; FixN YP_002313420.1 IPR008957, Fibronectin, type III-like fold YP_002313421.1 IPR011462, Protein of unknown function DUF1568 YP_002313422.1 IPR008957, Fibronectin, type III-like fold YP_002313425.1 catalyzes the formation of pyruvate and beta-alanine from L-alanine and 3-oxopropanoate YP_002313428.1 IPR010239, Conserved hypothetical protein 2001 YP_002313434.1 IPR007163, Protein of unknown function DUF368 YP_002313435.1 similar to superfamily SSF54637 Thioesterase/thiol ester dehydrase-isomerase YP_002313454.1 similar to superfamily SSF75169 YchN-like YP_002313461.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides YP_002313470.1 Phage integrase:Phage integrase, N-terminal SAM-like YP_002313473.1 facilitates an early step in the assembly of the 50S subunit of the ribosome YP_002313482.1 class II aldolase; catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis YP_002313483.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_002313484.1 NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate YP_002313485.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_002313486.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_002313497.1 IPR005184, Protein of unknown function DUF306, Meta and HslJ YP_002313503.1 pyrophosphatase; has activity against dUTP and dITP; the crystal structure of the Vibrio protein showed similarity to Methanococcus janaschii Mj0226; in Vibrio cholerae this gene is part of the Mba operon that is involved in regulation and maintenance of biofilms; in Escherichia coli overexpression of this gene leads to resistance to an HMP analog YP_002313513.1 IPR012544, Protein of unknown function DUF1696 YP_002313519.1 Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon YP_002313523.1 flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine YP_002313532.1 IPR008960, Carbohydrate-binding family 9, cellobiose dehydrogenase cytochrome YP_002313541.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_002313558.1 IPR012336, Thioredoxin-like fold YP_002313575.1 transcriptional repressor of asnA which codes for aspartate-ammonia ligase YP_002313579.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive YP_002313582.1 Peptidase S9, prolyl oligopeptidase active site region:Peptidase S9B, dipeptidylpeptidase IV N-terminal YP_002313583.1 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate YP_002313590.1 similar to superfamily SSF56726 DNA topoisomerase IV, alpha subunit YP_002313595.1 IPR008996, Cytokine, IL-1-like protein YP_002313601.1 IPR007329, FMN-binding YP_002313616.1 catalyzes the removal of an N-terminal amino acid from a peptide or arylamide YP_002313617.1 Regulatory factor involved in maltose metabolism YP_002313622.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate YP_002313623.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine YP_002313634.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters YP_002313646.1 Peptidase S9, prolyl oligopeptidase active site region:Peptidase S9B, dipeptidylpeptidase IV N-terminal YP_002313653.1 IPR009003, Peptidase, trypsin-like serine and cysteine proteases YP_002313658.1 IPR001727, Protein of unknown function UPF0016 YP_002313668.1 catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides YP_002313672.1 similar to superfamily SSF56935 Porins YP_002313678.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate YP_002313684.1 IPR003838, Protein of unknown function DUF214 YP_002313687.1 periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC YP_002313697.1 Carbamoyl-phosphate synthase L chain, ATP-binding:Carbamoyl-phosphate synthetase large chain, N-terminal:Biotin carboxylase, C-terminal YP_002313701.1 similar to superfamily SSF53182 Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) YP_002313702.1 IPR005622, Protein of unknown function DUF335, SprT; IPR006640, Protein of unknown function SprT YP_002313704.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_002313706.1 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione YP_002313709.1 IPR005646, Protein of unknown function DUF342 YP_002313715.1 IPR010879, Protein of unknown function DUF1508 YP_002313724.1 IPR002790, Protein of unknown function DUF88 YP_002313725.1 IPR002711, HNH endonuclease YP_002313738.1 similar to superfamily SSF55874 ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase YP_002313745.1 catalyzes the S-adenosylmethionine-dependent transmethylation of thiopurine compounds; may be involved in selenium cycling by forming dimethylselenide and/or dimethyldiselenide YP_002313750.1 two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm YP_002313780.1 Helicase, C-terminal:DbpA, RNA-binding:DEAD/DEAH box helicase, N-terminal YP_002313785.1 multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways YP_002313787.1 when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis YP_002313788.1 IPR002781, Protein of unknown function DUF81 YP_002313794.1 IPR006311, Twin-arginine translocation pathway signal YP_002313797.1 similar to superfamily SSF56935 Porins YP_002313822.1 ATP-binding region, ATPase-like:Histidine kinase A, N-terminal YP_002313833.1 D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm YP_002313844.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis YP_002313848.1 IPR001853, DSBA oxidoreductase; IPR012336, Thioredoxin-like fold YP_002313854.1 IPR001378, Protein of unknown function UPF0066 YP_002313867.1 NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin YP_002313869.1 Transcriptional regulatory protein, C-terminal YP_002313884.1 TPR repeat:Transcriptional regulatory protein, C-terminal YP_002313891.1 similar to superfamily SSF56059 Glutathione synthetase ATP-binding domain-like YP_002313898.1 similar to superfamily SSF51905 FAD/NAD(P)-binding domain YP_002313909.1 IPR007404, Predicted membrane-bound metal-dependent hydrolase YP_002313916.1 catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway YP_002313917.1 unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair. YP_002313925.1 catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway YP_002313938.1 IPR002876, Protein of unknown function DUF28 YP_002313939.1 IPR007263, Putative thiol-disulphide oxidoreductase DCC YP_002313943.1 mediates expression of the zinc export protein ZntA in response to high levels of zinc; member of MerR family of transcriptional regulators YP_002313945.1 involved in de novo purine biosynthesis YP_002313946.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_002313952.1 Response regulator receiver:Transcriptional regulatory protein, C-terminal YP_002313953.1 ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Histidine kinase A, N-terminal YP_002313956.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III YP_002313958.1 binds specifically to the major sigma factor sigma 70; active in stationary phase YP_002313959.1 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate YP_002313960.1 YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate YP_002313967.1 E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_002313970.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC YP_002313971.1 activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex YP_002313972.1 involved in regulation of beta-lactamase; putative signaling protein YP_002313982.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis YP_002313983.1 IPR009777, Protein of unknown function DUF1342 YP_002313984.1 IPR005584, Protein of unknown function DUF329 YP_002313986.1 Insulinase-like:Peptidase M16, C-terminal YP_002313988.1 Insulinase-like:Peptidase M16, C-terminal YP_002314006.1 uncharacterized member of the APC superfamily of amino acid transporters; unknown function YP_002314008.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis YP_002314010.1 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate YP_002314013.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters YP_002314018.1 IPR009525, Protein of unknown function DUF1145 YP_002314019.1 NapC/NirT cytochrome c, N-terminal YP_002314032.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA YP_002314033.1 Represses a number of genes involved in the response to DNA damage YP_002314037.1 involved in the insertion of copper into subunit I of cytochrome C oxidase YP_002314046.1 converts protoheme IX and farnesyl diphosphate to heme O YP_002314051.1 cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source YP_002314058.1 Transcriptional regulatory protein, C-terminal YP_002314071.1 part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation YP_002314073.1 membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR YP_002314095.1 catalyzes the formation of inosine from adenosine YP_002314103.1 IPR007536, Protein of unknown function DUF548 YP_002314108.1 IPR007473, Protein of unknown function DUF519 YP_002314112.1 sodium/drug antiporter; functions as a Na(+)-driven Na(+)/drug antiporter; member of multidrug and toxic compound extrusion (MATE) family; extrudes acriflavines and other compounds by utilizing the sodium gradient YP_002314130.1 similar to superfamily SSF54637 Thioesterase/thiol ester dehydrase-isomerase YP_002314134.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense YP_002314137.1 involved in the synthesis of a cofactor required for carnitine dehydratase and carnitine racemase activities YP_002314139.1 catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA YP_002314141.1 catalyzes formation of L-carnitinyl-CoA by transfering the CoA moiety from gamma-butyrobetainyl-CoA, also catalyzes the formation of crotonobetainyl-CoA by transfer of CoA from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine YP_002314142.1 catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA YP_002314143.1 catalyzes the exchange of L-carnitine for gamma-butyrobetaine in carnitine metabolism YP_002314144.1 required for anaerobic carnitine reduction, may act to transfer electrons to crotonobetaine reductase YP_002314171.1 IPR003339, Cobalt transport protein YP_002314176.1 IPR003744, Protein of unknown function DUF165 YP_002314186.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z YP_002314194.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases YP_002314197.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_002314199.1 ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Histidine kinase A, N-terminal YP_002314200.1 Response regulator receiver:Transcriptional regulatory protein, C-terminal YP_002314202.1 IPR005220, Conserved hypothetical protein 156; IPR008994, Nucleic acid-binding, OB-fold YP_002314208.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis YP_002314210.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z YP_002314219.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_002314239.1 IPR008324, Uncharacterised conserved protein UCP033623 YP_002314248.1 IPR008551, Protein of unknown function DUF833 YP_002314249.1 similar to superfamily SSF54427 NTF2-like YP_002314254.1 catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose YP_002314260.1 similar to superfamily SSF53756 UDP-Glycosyltransferase/glycogen phosphorylase YP_002314263.1 catalyzes the phosphorylation of 3-deoxy-D-manno-octulosonic acid at the 4-OH position YP_002314264.1 Three-deoxy-D-manno-octulosonic-acid transferase, N-terminal YP_002314268.1 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine YP_002314269.1 converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism YP_002314276.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential YP_002314278.1 similar to superfamily SSF53335 S-adenosyl-L-methionine-dependent methyltransferases YP_002314279.1 IPR007336, Protein of unknown function DUF414 YP_002314281.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_002314282.1 IPR010281, Protein of unknown function DUF885, bacterial YP_002314288.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus YP_002314290.1 IPR001543, Surface presentation of antigens (SPOA) protein YP_002314294.1 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod; the Vibrio parahaemolyticus protein is associated with the lateral flagella YP_002314295.1 One of three proteins involved in switching the direction of the flagellar rotation YP_002314296.1 binds to and inhibits the function of flagella specific ATPase FliI YP_002314299.1 IPR001041, Ferredoxin YP_002314300.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription YP_002314307.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the lateral flagella YP_002314310.1 the hook connects flagellar basal body to the flagellar filament; Vibrio parahaemolyticus protein is associated with the lateral flagella YP_002314313.1 part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod YP_002314314.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum YP_002314315.1 FlgJ; flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space; like the lateral flagella FlgJ in Vibrio parahaemolyticus this protein does not contains a C-terminal muramidase domain YP_002314317.1 Flagellin, N-terminal YP_002314320.1 Flagellin, C-terminal:Flagellin, N-terminal YP_002314321.1 Flagellar hook-associated protein 2, N-terminal:Flagellar hook-associated 2, C-terminal YP_002314326.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes YP_002314338.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA YP_002314345.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_002314350.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_002314357.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane YP_002314358.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_002314359.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_002314360.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_002314361.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex YP_002314362.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. YP_002314363.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 YP_002314364.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_002314368.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA YP_002314369.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs