-- dump date   	20111121_014751
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
744872000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
744872000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
744872000003	Walker A motif; other site
744872000004	ATP binding site [chemical binding]; other site
744872000005	Walker B motif; other site
744872000006	arginine finger; other site
744872000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
744872000008	DnaA box-binding interface [nucleotide binding]; other site
744872000009	DNA polymerase III subunit beta; Provisional; Region: PRK14940
744872000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140
744872000011	putative DNA binding surface [nucleotide binding]; other site
744872000012	dimer interface [polypeptide binding]; other site
744872000013	beta-clamp/clamp loader binding surface; other site
744872000014	beta-clamp/translesion DNA polymerase binding surface; other site
744872000015	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872000016	Walker A/P-loop; other site
744872000017	ATP binding site [chemical binding]; other site
744872000018	Q-loop/lid; other site
744872000019	Protein of unknown function (DUF721); Region: DUF721; cl02324
744872000020	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
744872000021	Ribonuclease P; Region: Ribonuclease_P; cl00457
744872000022	membrane protein insertase; Provisional; Region: PRK01318
744872000023	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
744872000024	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
744872000025	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
744872000026	G-X-X-G motif; other site
744872000027	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
744872000028	RxxxH motif; other site
744872000029	flagellin; Provisional; Region: PRK12804
744872000030	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
744872000031	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
744872000032	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
744872000033	Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052
744872000034	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
744872000035	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
744872000036	active site
744872000037	NAD binding site [chemical binding]; other site
744872000038	metal binding site [ion binding]; metal-binding site
744872000039	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
744872000040	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
744872000041	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
744872000042	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
744872000043	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
744872000044	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
744872000045	Uncharacterized conserved protein [Function unknown]; Region: COG0327
744872000046	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412
744872000047	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
744872000048	lipoprotein signal peptidase; Provisional; Region: PRK14787
744872000049	Domain of unknown function (DUF1848); Region: DUF1848; pfam08902
744872000050	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
744872000051	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
744872000052	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
744872000053	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872000054	NAD(P) binding pocket [chemical binding]; other site
744872000055	hybrid cluster protein; Provisional; Region: PRK05290
744872000056	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655
744872000057	ACS interaction site; other site
744872000058	CODH interaction site; other site
744872000059	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
744872000060	hybrid metal cluster; other site
744872000061	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586
744872000062	active site
744872000063	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
744872000064	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447
744872000065	nudix motif; other site
744872000066	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
744872000067	ligand binding site [chemical binding]; other site
744872000068	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
744872000069	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
744872000070	Histidine kinase; Region: His_kinase; pfam06580
744872000071	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872000072	ATP binding site [chemical binding]; other site
744872000073	Mg2+ binding site [ion binding]; other site
744872000074	G-X-G motif; other site
744872000075	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
744872000076	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872000077	active site
744872000078	phosphorylation site [posttranslational modification]
744872000079	intermolecular recognition site; other site
744872000080	dimerization interface [polypeptide binding]; other site
744872000081	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
744872000082	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
744872000083	putative ligand binding site [chemical binding]; other site
744872000084	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
744872000085	putative ligand binding site [chemical binding]; other site
744872000086	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
744872000087	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216
744872000088	Walker A/P-loop; other site
744872000089	ATP binding site [chemical binding]; other site
744872000090	Q-loop/lid; other site
744872000091	ABC transporter signature motif; other site
744872000092	Walker B; other site
744872000093	D-loop; other site
744872000094	H-loop/switch region; other site
744872000095	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215
744872000096	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
744872000097	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
744872000098	TM-ABC transporter signature motif; other site
744872000099	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
744872000100	MatE; Region: MatE; cl10513
744872000101	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
744872000102	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
744872000103	Peptidase family M23; Region: Peptidase_M23; pfam01551
744872000104	Polymer-forming cytoskeletal; Region: Bactofilin; cl09137
744872000105	Protein of unknown function (DUF327); Region: DUF327; cl00753
744872000106	PSP1 C-terminal conserved region; Region: PSP1; cl00770
744872000107	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
744872000108	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
744872000109	S-adenosylmethionine binding site [chemical binding]; other site
744872000110	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
744872000111	Beta-galactosidase; Region: Glyco_hydro_42; cl03154
744872000112	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
744872000113	Thymidylate synthase complementing protein; Region: Thy1; cl03630
744872000114	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
744872000115	Zn2+ binding site [ion binding]; other site
744872000116	Mg2+ binding site [ion binding]; other site
744872000117	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564
744872000118	Cache domain; Region: Cache_2; cl07034
744872000119	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225
744872000120	dimerization interface [polypeptide binding]; other site
744872000121	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
744872000122	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
744872000123	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
744872000124	N- and C-terminal domain interface [polypeptide binding]; other site
744872000125	D-xylulose kinase; Region: XylB; TIGR01312
744872000126	active site
744872000127	MgATP binding site [chemical binding]; other site
744872000128	catalytic site [active]
744872000129	metal binding site [ion binding]; metal-binding site
744872000130	carbohydrate binding site [chemical binding]; other site
744872000131	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
744872000132	active site
744872000133	catalytic triad [active]
744872000134	Pectinesterase; Region: Pectinesterase; cl01911
744872000135	Pectate lyase; Region: Pec_lyase_C; cl01593
744872000136	Transcriptional regulators [Transcription]; Region: PurR; COG1609
744872000137	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
744872000138	DNA binding site [nucleotide binding]
744872000139	domain linker motif; other site
744872000140	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
744872000141	ligand binding site [chemical binding]; other site
744872000142	L-ribulokinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778
744872000143	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
744872000144	putative N- and C-terminal domain interface [polypeptide binding]; other site
744872000145	putative active site [active]
744872000146	putative MgATP binding site [chemical binding]; other site
744872000147	catalytic site [active]
744872000148	metal binding site [ion binding]; metal-binding site
744872000149	putative carbohydrate binding site [chemical binding]; other site
744872000150	DinB superfamily; Region: DinB_2; cl00986
744872000151	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
744872000152	active site
744872000153	8-oxo-dGMP binding site [chemical binding]; other site
744872000154	nudix motif; other site
744872000155	metal binding site [ion binding]; metal-binding site
744872000156	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
744872000157	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
744872000158	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
744872000159	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872000160	dimer interface [polypeptide binding]; other site
744872000161	conserved gate region; other site
744872000162	putative PBP binding loops; other site
744872000163	ABC-ATPase subunit interface; other site
744872000164	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
744872000165	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
744872000166	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
744872000167	GAF domain; Region: GAF; cl00853
744872000168	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
744872000169	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
744872000170	UvrD/REP helicase; Region: UvrD-helicase; cl14126
744872000171	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
744872000172	UvrD/REP helicase; Region: UvrD-helicase; cl14126
744872000173	ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857
744872000174	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
744872000175	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
744872000176	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
744872000177	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872000178	NAD(P) binding site [chemical binding]; other site
744872000179	active site
744872000180	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
744872000181	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
744872000182	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192
744872000183	substrate binding site [chemical binding]; other site
744872000184	ATP binding site [chemical binding]; other site
744872000185	Bacterial pullanase-associated domain; Region: PUD; pfam03714
744872000186	Gram-positive; Region: pullulan_Gpos; TIGR02102
744872000187	E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies.  These domains are associated with different types of catalytic domains at  either the N-terminal or C-terminal end; Region: E_set; cl09101
744872000188	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
744872000189	Glycosyl hydrolase family 79, N-terminal domain; Region: Glyco_hydro_79n; pfam03662
744872000190	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402
744872000191	active site
744872000192	catalytic site [active]
744872000193	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
744872000194	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
744872000195	active site
744872000196	NAD binding site [chemical binding]; other site
744872000197	metal binding site [ion binding]; metal-binding site
744872000198	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
744872000199	Histidine kinase; Region: HisKA_2; cl06527
744872000200	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872000201	ATP binding site [chemical binding]; other site
744872000202	Mg2+ binding site [ion binding]; other site
744872000203	G-X-G motif; other site
744872000204	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
744872000205	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
744872000206	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
744872000207	Protein export membrane protein; Region: SecD_SecF; cl14618
744872000208	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
744872000209	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
744872000210	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
744872000211	Transposase domain (DUF772); Region: DUF772; cl12084
744872000212	Response regulator receiver domain; Region: Response_reg; pfam00072
744872000213	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872000214	active site
744872000215	phosphorylation site [posttranslational modification]
744872000216	intermolecular recognition site; other site
744872000217	dimerization interface [polypeptide binding]; other site
744872000218	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392
744872000219	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl00408
744872000220	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801
744872000221	pullulanase, type I; Region: pulA_typeI; TIGR02104
744872000222	Pullulanase domain N-terminus. Pullulanase (AKA dextrinase; alpha-dextrin endo-1,6-alpha glucosidase) is an enzyme with action similar to that of isoamylase; it cleaves 1,6-alpha-glucosidic linkages in pullulan, amylopectin, and glycogen, and in alpha-...; Region: Pullulanase_N_term; cd02860
744872000223	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
744872000224	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
744872000225	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
744872000226	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
744872000227	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872000228	dimer interface [polypeptide binding]; other site
744872000229	conserved gate region; other site
744872000230	putative PBP binding loops; other site
744872000231	ABC-ATPase subunit interface; other site
744872000232	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872000233	dimer interface [polypeptide binding]; other site
744872000234	conserved gate region; other site
744872000235	putative PBP binding loops; other site
744872000236	ABC-ATPase subunit interface; other site
744872000237	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
744872000238	maltodextrin glucosidase; Provisional; Region: PRK10785
744872000239	CD and pullulan-degrading enzymes N-terminus domain.  Members of this subgroup include: Cyclomaltodextrinase (CDase), maltogenic amylase, and neopullulanase all of which are capable of hydrolyzing all or two of the following three types of substrates:...; Region: CD_pullulan_degrading_enzymes_N_term; cd02857
744872000240	homodimer; other site
744872000241	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
744872000242	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl08495
744872000243	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
744872000244	active site
744872000245	NTP binding site [chemical binding]; other site
744872000246	metal binding triad [ion binding]; metal-binding site
744872000247	antibiotic binding site [chemical binding]; other site
744872000248	Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112
744872000249	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
744872000250	Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691
744872000251	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
744872000252	Phd_YefM; Region: PhdYeFM; cl09153
744872000253	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
744872000254	putative active site [active]
744872000255	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
744872000256	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
744872000257	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_c; cd10311
744872000258	putative active site [active]
744872000259	catalytic site [active]
744872000260	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
744872000261	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
744872000262	ATP binding site [chemical binding]; other site
744872000263	putative Mg++ binding site [ion binding]; other site
744872000264	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
744872000265	nucleotide binding region [chemical binding]; other site
744872000266	ATP-binding site [chemical binding]; other site
744872000267	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
744872000268	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
744872000269	Walker A motif; other site
744872000270	ATP binding site [chemical binding]; other site
744872000271	Walker B motif; other site
744872000272	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
744872000273	oligomeric interface; other site
744872000274	putative active site [active]
744872000275	homodimer interface [polypeptide binding]; other site
744872000276	SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877
744872000277	Protein of unknown function (DUF1625); Region: DUF1625; pfam07787
744872000278	CLUSTERIN Beta chain; Region: CLb; smart00030
744872000279	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
744872000280	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
744872000281	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
744872000282	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
744872000283	active site
744872000284	ATP binding site [chemical binding]; other site
744872000285	substrate binding site [chemical binding]; other site
744872000286	Phosphatidylinositol N-acetylglucosaminyltransferase; Region: GPI2; pfam06432
744872000287	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
744872000288	metal binding site [ion binding]; metal-binding site
744872000289	active site
744872000290	I-site; other site
744872000291	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
744872000292	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
744872000293	putative active site [active]
744872000294	serine hydroxymethyltransferase; Provisional; Region: PRK13580
744872000295	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378
744872000296	dimer interface [polypeptide binding]; other site
744872000297	glycine-pyridoxal phosphate binding site [chemical binding]; other site
744872000298	active site
744872000299	folate binding site [chemical binding]; other site
744872000300	Domain of unknown function (DUF336); Region: DUF336; cl01249
744872000301	Protein of unknown function (DUF1498); Region: DUF1498; cl01576
744872000302	Histidine kinase; Region: HisKA_3; pfam07730
744872000303	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872000304	ATP binding site [chemical binding]; other site
744872000305	Mg2+ binding site [ion binding]; other site
744872000306	G-X-G motif; other site
744872000307	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
744872000308	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872000309	active site
744872000310	phosphorylation site [posttranslational modification]
744872000311	intermolecular recognition site; other site
744872000312	dimerization interface [polypeptide binding]; other site
744872000313	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
744872000314	DNA binding residues [nucleotide binding]
744872000315	dimerization interface [polypeptide binding]; other site
744872000316	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
744872000317	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
744872000318	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
744872000319	ligand binding site [chemical binding]; other site
744872000320	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
744872000321	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321
744872000322	putative ligand binding site [chemical binding]; other site
744872000323	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
744872000324	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216
744872000325	Walker A/P-loop; other site
744872000326	ATP binding site [chemical binding]; other site
744872000327	Q-loop/lid; other site
744872000328	ABC transporter signature motif; other site
744872000329	Walker B; other site
744872000330	D-loop; other site
744872000331	H-loop/switch region; other site
744872000332	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215
744872000333	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
744872000334	TM-ABC transporter signature motif; other site
744872000335	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
744872000336	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
744872000337	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
744872000338	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192
744872000339	substrate binding site [chemical binding]; other site
744872000340	ATP binding site [chemical binding]; other site
744872000341	tocopherol cyclase; Region: PLN02818
744872000342	Rhomboid family; Region: Rhomboid; cl11446
744872000343	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
744872000344	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-...; Region: DHOD_e_trans_like1; cd06219
744872000345	FAD binding pocket [chemical binding]; other site
744872000346	FAD binding motif [chemical binding]; other site
744872000347	phosphate binding motif [ion binding]; other site
744872000348	beta-alpha-beta structure motif; other site
744872000349	NAD binding pocket [chemical binding]; other site
744872000350	Iron coordination center [ion binding]; other site
744872000351	putative oxidoreductase; Provisional; Region: PRK12831
744872000352	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872000353	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872000354	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
744872000355	ligand binding site [chemical binding]; other site
744872000356	flexible hinge region; other site
744872000357	NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530
744872000358	CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409
744872000359	active site
744872000360	metal binding site [ion binding]; metal-binding site
744872000361	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
744872000362	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872000363	TPR motif; other site
744872000364	binding surface
744872000365	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872000366	TPR motif; other site
744872000367	binding surface
744872000368	potential frameshift: common BLAST hit: gi|333999351|ref|YP_004531963.1| putative heptaprenyl diphosphate synthase component I
744872000369	Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; cl01973
744872000370	NGN-insert domain found between N-terminal domain (D1) and C-terminal KOW domain (DIII) repeats of some N-Utilization Substance G (NusG) N-terminal (NGN); Region: NGN-insert_like; cd09910
744872000371	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
744872000372	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
744872000373	atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265
744872000374	putative NAD(P) binding site [chemical binding]; other site
744872000375	active site
744872000376	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
744872000377	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
744872000378	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
744872000379	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
744872000380	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
744872000381	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
744872000382	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
744872000383	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872000384	dimer interface [polypeptide binding]; other site
744872000385	conserved gate region; other site
744872000386	putative PBP binding loops; other site
744872000387	ABC-ATPase subunit interface; other site
744872000388	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
744872000389	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872000390	dimer interface [polypeptide binding]; other site
744872000391	conserved gate region; other site
744872000392	putative PBP binding loops; other site
744872000393	ABC-ATPase subunit interface; other site
744872000394	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
744872000395	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
744872000396	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
744872000397	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872000398	active site
744872000399	phosphorylation site [posttranslational modification]
744872000400	intermolecular recognition site; other site
744872000401	dimerization interface [polypeptide binding]; other site
744872000402	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
744872000403	DNA binding residues [nucleotide binding]
744872000404	dimerization interface [polypeptide binding]; other site
744872000405	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
744872000406	Histidine kinase; Region: HisKA_3; pfam07730
744872000407	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872000408	ATP binding site [chemical binding]; other site
744872000409	Mg2+ binding site [ion binding]; other site
744872000410	G-X-G motif; other site
744872000411	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
744872000412	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
744872000413	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
744872000414	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872000415	Walker A/P-loop; other site
744872000416	ATP binding site [chemical binding]; other site
744872000417	Q-loop/lid; other site
744872000418	ABC transporter signature motif; other site
744872000419	Walker B; other site
744872000420	D-loop; other site
744872000421	H-loop/switch region; other site
744872000422	Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044
744872000423	diiron binding motif [ion binding]; other site
744872000424	CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431
744872000425	Adenosine specific kinase; Region: Adenosine_kin; cl00796
744872000426	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK09616
744872000427	B3/4 domain; Region: B3_4; cl11458
744872000428	tRNA synthetase B5 domain; Region: B5; cl08394
744872000429	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
744872000430	dimer interface [polypeptide binding]; other site
744872000431	motif 1; other site
744872000432	motif 3; other site
744872000433	motif 2; other site
744872000434	phenylalanyl-tRNA synthetase subunit alpha; Provisional; Region: pheS; PRK04172
744872000435	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
744872000436	dimer interface [polypeptide binding]; other site
744872000437	motif 1; other site
744872000438	active site
744872000439	motif 2; other site
744872000440	motif 3; other site
744872000441	Uncharacterised protein family UPF0047; Region: UPF0047; cl00439
744872000442	Rhomboid family; Region: Rhomboid; cl11446
744872000443	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
744872000444	catalytic loop [active]
744872000445	iron binding site [ion binding]; other site
744872000446	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
744872000447	GAF domain; Region: GAF; cl00853
744872000448	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
744872000449	metal binding site [ion binding]; metal-binding site
744872000450	active site
744872000451	I-site; other site
744872000452	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
744872000453	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801
744872000454	FMN binding site [chemical binding]; other site
744872000455	active site
744872000456	catalytic residues [active]
744872000457	substrate binding site [chemical binding]; other site
744872000458	putative deoxyribonuclease YjjV; Provisional; Region: PRK11449
744872000459	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
744872000460	active site
744872000461	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
744872000462	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
744872000463	catalytic motif [active]
744872000464	Zn binding site [ion binding]; other site
744872000465	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161
744872000466	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
744872000467	Lumazine binding domain; Region: Lum_binding; pfam00677
744872000468	Lumazine binding domain; Region: Lum_binding; pfam00677
744872000469	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
744872000470	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
744872000471	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
744872000472	dimerization interface [polypeptide binding]; other site
744872000473	active site
744872000474	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
744872000475	homopentamer interface [polypeptide binding]; other site
744872000476	active site
744872000477	bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427
744872000478	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
744872000479	dimer interface [polypeptide binding]; other site
744872000480	substrate binding site [chemical binding]; other site
744872000481	ATP binding site [chemical binding]; other site
744872000482	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
744872000483	substrate binding site [chemical binding]; other site
744872000484	multimerization interface [polypeptide binding]; other site
744872000485	ATP binding site [chemical binding]; other site
744872000486	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564
744872000487	thiamine phosphate binding site [chemical binding]; other site
744872000488	active site
744872000489	pyrophosphate binding site [ion binding]; other site
744872000490	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
744872000491	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
744872000492	active site
744872000493	motif II; other site
744872000494	anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564
744872000495	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
744872000496	chorismate binding enzyme; Region: Chorismate_bind; cl10555
744872000497	bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK14607
744872000498	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
744872000499	glutamine binding [chemical binding]; other site
744872000500	catalytic triad [active]
744872000501	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
744872000502	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
744872000503	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
744872000504	active site
744872000505	ribulose/triose binding site [chemical binding]; other site
744872000506	phosphate binding site [ion binding]; other site
744872000507	substrate (anthranilate) binding pocket [chemical binding]; other site
744872000508	product (indole) binding pocket [chemical binding]; other site
744872000509	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
744872000510	phosphate binding site [ion binding]; other site
744872000511	tryptophan synthase, beta chain; Region: PLN02618
744872000512	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
744872000513	pyridoxal 5'-phosphate binding site [chemical binding]; other site
744872000514	catalytic residue [active]
744872000515	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724
744872000516	substrate binding site [chemical binding]; other site
744872000517	active site
744872000518	catalytic residues [active]
744872000519	heterodimer interface [polypeptide binding]; other site
744872000520	hypothetical protein; Provisional; Region: PRK00955
744872000521	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
744872000522	NifU-like domain; Region: NifU; cl00484
744872000523	SlyX; Region: SlyX; cl01090
744872000524	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204
744872000525	6-phosphofructokinase; Provisional; Region: PRK03202
744872000526	active site
744872000527	ADP/pyrophosphate binding site [chemical binding]; other site
744872000528	dimerization interface [polypeptide binding]; other site
744872000529	allosteric effector site; other site
744872000530	fructose-1,6-bisphosphate binding site; other site
744872000531	Uncharacterized conserved protein [Function unknown]; Region: COG3875
744872000532	Domain of unknown function (DUF2088); Region: DUF2088; pfam09861
744872000533	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
744872000534	dimer interface [polypeptide binding]; other site
744872000535	phosphorylation site [posttranslational modification]
744872000536	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872000537	ATP binding site [chemical binding]; other site
744872000538	Mg2+ binding site [ion binding]; other site
744872000539	G-X-G motif; other site
744872000540	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
744872000541	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
744872000542	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
744872000543	alanyl-tRNA synthetase; Provisional; Region: alaS; PRK13902
744872000544	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
744872000545	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
744872000546	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
744872000547	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
744872000548	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
744872000549	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
744872000550	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
744872000551	Outer membrane efflux protein; Region: OEP; pfam02321
744872000552	Outer membrane efflux protein; Region: OEP; pfam02321
744872000553	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404
744872000554	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
744872000555	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
744872000556	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
744872000557	active site
744872000558	dimerization interface [polypeptide binding]; other site
744872000559	ApbE family; Region: ApbE; cl00643
744872000560	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
744872000561	active site
744872000562	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
744872000563	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
744872000564	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
744872000565	PAS domain S-box; Region: sensory_box; TIGR00229
744872000566	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
744872000567	putative active site [active]
744872000568	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
744872000569	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
744872000570	putative active site [active]
744872000571	heme pocket [chemical binding]; other site
744872000572	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
744872000573	dimer interface [polypeptide binding]; other site
744872000574	phosphorylation site [posttranslational modification]
744872000575	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872000576	ATP binding site [chemical binding]; other site
744872000577	Mg2+ binding site [ion binding]; other site
744872000578	G-X-G motif; other site
744872000579	Response regulator receiver domain; Region: Response_reg; pfam00072
744872000580	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872000581	active site
744872000582	phosphorylation site [posttranslational modification]
744872000583	intermolecular recognition site; other site
744872000584	dimerization interface [polypeptide binding]; other site
744872000585	glycerol kinase; Provisional; Region: glpK; PRK00047
744872000586	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
744872000587	N- and C-terminal domain interface [polypeptide binding]; other site
744872000588	active site
744872000589	MgATP binding site [chemical binding]; other site
744872000590	catalytic site [active]
744872000591	metal binding site [ion binding]; metal-binding site
744872000592	glycerol binding site [chemical binding]; other site
744872000593	homotetramer interface [polypeptide binding]; other site
744872000594	homodimer interface [polypeptide binding]; other site
744872000595	FBP binding site [chemical binding]; other site
744872000596	protein IIAGlc interface [polypeptide binding]; other site
744872000597	recombination protein RecR; Reviewed; Region: recR; PRK00076
744872000598	RecR protein; Region: RecR; pfam02132
744872000599	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
744872000600	putative active site [active]
744872000601	putative metal-binding site [ion binding]; other site
744872000602	tetramer interface [polypeptide binding]; other site
744872000603	Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494
744872000604	DNA polymerase III subunits gamma and tau; Validated; Region: PRK06647
744872000605	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
744872000606	Walker A motif; other site
744872000607	ATP binding site [chemical binding]; other site
744872000608	Walker B motif; other site
744872000609	arginine finger; other site
744872000610	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
744872000611	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
744872000612	motif II; other site
744872000613	Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
744872000614	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
744872000615	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
744872000616	active site
744872000617	metal binding site [ion binding]; metal-binding site
744872000618	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
744872000619	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
744872000620	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
744872000621	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872000622	dimer interface [polypeptide binding]; other site
744872000623	conserved gate region; other site
744872000624	putative PBP binding loops; other site
744872000625	ABC-ATPase subunit interface; other site
744872000626	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
744872000627	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872000628	dimer interface [polypeptide binding]; other site
744872000629	ABC-ATPase subunit interface; other site
744872000630	putative PBP binding loops; other site
744872000631	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
744872000632	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
744872000633	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
744872000634	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
744872000635	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872000636	active site
744872000637	phosphorylation site [posttranslational modification]
744872000638	intermolecular recognition site; other site
744872000639	dimerization interface [polypeptide binding]; other site
744872000640	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
744872000641	DNA binding residues [nucleotide binding]
744872000642	dimerization interface [polypeptide binding]; other site
744872000643	Histidine kinase; Region: HisKA_3; pfam07730
744872000644	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
744872000645	Phd_YefM; Region: PhdYeFM; cl09153
744872000646	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
744872000647	putative active site [active]
744872000648	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:; Region: TRX_Fd_family; cd02980
744872000649	dimer interface [polypeptide binding]; other site
744872000650	[2Fe-2S] cluster binding site [ion binding]; other site
744872000651	ferredoxin; Validated; Region: PRK07118
744872000652	4Fe-4S binding domain; Region: Fer4; cl02805
744872000653	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
744872000654	Putative Fe-S cluster; Region: FeS; pfam04060
744872000655	PAS fold; Region: PAS; pfam00989
744872000656	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
744872000657	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
744872000658	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
744872000659	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of...; Region: TRX_Fd_NuoE; cd03064
744872000660	putative dimer interface [polypeptide binding]; other site
744872000661	[2Fe-2S] cluster binding site [ion binding]; other site
744872000662	ferredoxin; Validated; Region: PRK07118
744872000663	4Fe-4S binding domain; Region: Fer4; cl02805
744872000664	hydrogenase, Fe-only; Region: Fe_only_hydrog; TIGR02512
744872000665	4Fe-4S binding domain; Region: Fer4; cl02805
744872000666	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
744872000667	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012
744872000668	SEC-C motif; Region: SEC-C; cl12132
744872000669	SEC-C motif; Region: SEC-C; cl12132
744872000670	EamA-like transporter family; Region: EamA; cl01037
744872000671	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
744872000672	EamA-like transporter family; Region: EamA; cl01037
744872000673	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369
744872000674	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
744872000675	hinge; other site
744872000676	active site
744872000677	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257
744872000678	HSP70 interaction site [polypeptide binding]; other site
744872000679	Protein of unknown function (DUF3433); Region: DUF3433; pfam11915
744872000680	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
744872000681	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944
744872000682	DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766
744872000683	dimerization interface [polypeptide binding]; other site
744872000684	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
744872000685	DNA binding site [nucleotide binding]
744872000686	phage shock protein PspA; Provisional; Region: PRK10698
744872000687	phage shock protein A; Region: phageshock_pspA; TIGR02977
744872000688	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
744872000689	anti sigma factor interaction site; other site
744872000690	regulatory phosphorylation site [posttranslational modification]; other site
744872000691	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
744872000692	classical (c) SDRs; Region: SDR_c; cd05233
744872000693	NAD(P) binding site [chemical binding]; other site
744872000694	active site
744872000695	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
744872000696	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
744872000697	Response regulator receiver domain; Region: Response_reg; pfam00072
744872000698	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872000699	active site
744872000700	phosphorylation site [posttranslational modification]
744872000701	intermolecular recognition site; other site
744872000702	dimerization interface [polypeptide binding]; other site
744872000703	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
744872000704	Walker A motif; other site
744872000705	ATP binding site [chemical binding]; other site
744872000706	Walker B motif; other site
744872000707	arginine finger; other site
744872000708	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cl04270
744872000709	RNA methyltransferase; Region: Methyltrans_RNA; cl00611
744872000710	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
744872000711	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
744872000712	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
744872000713	protein binding site [polypeptide binding]; other site
744872000714	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
744872000715	Catalytic dyad [active]
744872000716	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
744872000717	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
744872000718	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
744872000719	P-loop; other site
744872000720	Protein of unknown function (DUF342); Region: DUF342; pfam03961
744872000721	Protein of unknown function (DUF342); Region: DUF342; pfam03961
744872000722	Protein of unknown function (DUF342); Region: DUF342; pfam03961
744872000723	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
744872000724	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
744872000725	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342
744872000726	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
744872000727	catalytic residue [active]
744872000728	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
744872000729	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464
744872000730	putative dimer interface [polypeptide binding]; other site
744872000731	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
744872000732	transketolase; Reviewed; Region: PRK05899
744872000733	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
744872000734	TPP-binding site [chemical binding]; other site
744872000735	dimer interface [polypeptide binding]; other site
744872000736	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
744872000737	PYR/PP interface [polypeptide binding]; other site
744872000738	dimer interface [polypeptide binding]; other site
744872000739	TPP binding site [chemical binding]; other site
744872000740	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
744872000741	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
744872000742	putative acyl-acceptor binding pocket; other site
744872000743	Glycerate kinase family; Region: Gly_kinase; cl00841
744872000744	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
744872000745	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
744872000746	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
744872000747	ligand binding site [chemical binding]; other site
744872000748	spermidine synthase; Provisional; Region: PRK00811
744872000749	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
744872000750	S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687
744872000751	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973
744872000752	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
744872000753	Major Facilitator Superfamily; Region: MFS_1; pfam07690
744872000754	putative substrate translocation pore; other site
744872000755	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
744872000756	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
744872000757	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
744872000758	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
744872000759	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The...; Region: Peptidase_C39_like; cl00296
744872000760	putative active site [active]
744872000761	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
744872000762	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
744872000763	dimer interface [polypeptide binding]; other site
744872000764	anticodon binding site; other site
744872000765	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
744872000766	homodimer interface [polypeptide binding]; other site
744872000767	motif 1; other site
744872000768	active site
744872000769	motif 2; other site
744872000770	GAD domain; Region: GAD; pfam02938
744872000771	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
744872000772	active site
744872000773	motif 3; other site
744872000774	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
744872000775	MgtC family; Region: MgtC; cl12207
744872000776	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
744872000777	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
744872000778	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
744872000779	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
744872000780	motif II; other site
744872000781	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
744872000782	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
744872000783	N- and C-terminal domain interface [polypeptide binding]; other site
744872000784	active site
744872000785	MgATP binding site [chemical binding]; other site
744872000786	catalytic site [active]
744872000787	metal binding site [ion binding]; metal-binding site
744872000788	carbohydrate binding site [chemical binding]; other site
744872000789	phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827
744872000790	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
744872000791	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
744872000792	ligand binding site [chemical binding]; other site
744872000793	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
744872000794	SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877
744872000795	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
744872000796	oligomeric interface; other site
744872000797	putative active site [active]
744872000798	homodimer interface [polypeptide binding]; other site
744872000799	Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; cl15292
744872000800	Transposase domain (DUF772); Region: DUF772; cl12084
744872000801	Protein of unknown function (DUF2804); Region: DUF2804; pfam10974
744872000802	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
744872000803	hypothetical protein; Provisional; Region: PRK10977
744872000804	Pyruvate formate lyase; Region: PFL; pfam02901
744872000805	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
744872000806	glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041
744872000807	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259
744872000808	4Fe-4S binding domain; Region: Fer4; cl02805
744872000809	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
744872000810	FeS/SAM binding site; other site
744872000811	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
744872000812	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
744872000813	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
744872000814	Putative carbohydrate binding domain; Region: CBM_X; cl05621
744872000815	Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165
744872000816	Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205
744872000817	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
744872000818	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801
744872000819	Predicted integral membrane protein [Function unknown]; Region: COG5522; cl02331
744872000820	Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529
744872000821	Voltage-dependent potassium channel; Provisional; Region: PLN03192
744872000822	Ion channel; Region: Ion_trans_2; cl11596
744872000823	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
744872000824	ligand binding site [chemical binding]; other site
744872000825	flexible hinge region; other site
744872000826	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
744872000827	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
744872000828	Response regulator receiver domain; Region: Response_reg; pfam00072
744872000829	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872000830	active site
744872000831	phosphorylation site [posttranslational modification]
744872000832	intermolecular recognition site; other site
744872000833	dimerization interface [polypeptide binding]; other site
744872000834	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
744872000835	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
744872000836	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
744872000837	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
744872000838	dimer interface [polypeptide binding]; other site
744872000839	phosphorylation site [posttranslational modification]
744872000840	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872000841	ATP binding site [chemical binding]; other site
744872000842	Mg2+ binding site [ion binding]; other site
744872000843	G-X-G motif; other site
744872000844	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
744872000845	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872000846	active site
744872000847	phosphorylation site [posttranslational modification]
744872000848	intermolecular recognition site; other site
744872000849	dimerization interface [polypeptide binding]; other site
744872000850	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
744872000851	heat shock protein 90; Provisional; Region: PRK05218
744872000852	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872000853	ATP binding site [chemical binding]; other site
744872000854	Mg2+ binding site [ion binding]; other site
744872000855	G-X-G motif; other site
744872000856	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
744872000857	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402
744872000858	Transcriptional regulators [Transcription]; Region: MarR; COG1846
744872000859	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
744872000860	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
744872000861	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
744872000862	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872000863	Walker A/P-loop; other site
744872000864	ATP binding site [chemical binding]; other site
744872000865	Q-loop/lid; other site
744872000866	ABC transporter signature motif; other site
744872000867	Walker B; other site
744872000868	D-loop; other site
744872000869	H-loop/switch region; other site
744872000870	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
744872000871	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
744872000872	Glucan exporter ATP-binding protein.  In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor.  This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254
744872000873	Walker A/P-loop; other site
744872000874	ATP binding site [chemical binding]; other site
744872000875	Q-loop/lid; other site
744872000876	ABC transporter signature motif; other site
744872000877	Walker B; other site
744872000878	D-loop; other site
744872000879	H-loop/switch region; other site
744872000880	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
744872000881	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
744872000882	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
744872000883	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
744872000884	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
744872000885	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
744872000886	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
744872000887	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
744872000888	putative NAD(P) binding site [chemical binding]; other site
744872000889	putative active site [active]
744872000890	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
744872000891	dimerization interface [polypeptide binding]; other site
744872000892	ligand binding site [chemical binding]; other site
744872000893	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
744872000894	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872000895	ATP binding site [chemical binding]; other site
744872000896	Mg2+ binding site [ion binding]; other site
744872000897	G-X-G motif; other site
744872000898	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
744872000899	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872000900	active site
744872000901	phosphorylation site [posttranslational modification]
744872000902	intermolecular recognition site; other site
744872000903	dimerization interface [polypeptide binding]; other site
744872000904	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
744872000905	DNA binding residues [nucleotide binding]
744872000906	dimerization interface [polypeptide binding]; other site
744872000907	Glycosyl hydrolase family 52; Region: Glyco_hydro_52; pfam03512
744872000908	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
744872000909	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
744872000910	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
744872000911	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872000912	dimer interface [polypeptide binding]; other site
744872000913	conserved gate region; other site
744872000914	putative PBP binding loops; other site
744872000915	ABC-ATPase subunit interface; other site
744872000916	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
744872000917	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872000918	dimer interface [polypeptide binding]; other site
744872000919	conserved gate region; other site
744872000920	putative PBP binding loops; other site
744872000921	ABC-ATPase subunit interface; other site
744872000922	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
744872000923	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260
744872000924	Domain of unknown function (DUF1850); Region: DUF1850; cl01950
744872000925	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
744872000926	cyclase homology domain; Region: CHD; cd07302
744872000927	nucleotidyl binding site; other site
744872000928	metal binding site [ion binding]; metal-binding site
744872000929	dimer interface [polypeptide binding]; other site
744872000930	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
744872000931	trimerization site [polypeptide binding]; other site
744872000932	active site
744872000933	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
744872000934	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
744872000935	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
744872000936	catalytic residue [active]
744872000937	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
744872000938	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
744872000939	FeS assembly protein SufB; Region: sufB; TIGR01980
744872000940	ABC-type transport system involved in Fe-S cluster assembly, ATPase component.  Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems.  The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217
744872000941	FeS assembly ATPase SufC; Region: sufC; TIGR01978
744872000942	Walker A/P-loop; other site
744872000943	ATP binding site [chemical binding]; other site
744872000944	Q-loop/lid; other site
744872000945	ABC transporter signature motif; other site
744872000946	Walker B; other site
744872000947	D-loop; other site
744872000948	H-loop/switch region; other site
744872000949	Domain of unknown function DUF59; Region: DUF59; cl00941
744872000950	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
744872000951	RNA methyltransferase; Region: Methyltrans_RNA; cl00611
744872000952	Glutamine synthetase adenylyltransferase [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms]; Region: GlnE; COG1391
744872000953	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756
744872000954	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
744872000955	putative homodimer interface [polypeptide binding]; other site
744872000956	putative active site pocket [active]
744872000957	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
744872000958	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
744872000959	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
744872000960	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
744872000961	DNA binding residues [nucleotide binding]
744872000962	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
744872000963	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881
744872000964	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
744872000965	Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479
744872000966	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
744872000967	catalytic loop [active]
744872000968	iron binding site [ion binding]; other site
744872000969	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
744872000970	HflX subfamily.  A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily.  The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878
744872000971	G1 box; other site
744872000972	GTP/Mg2+ binding site [chemical binding]; other site
744872000973	Switch I region; other site
744872000974	G2 box; other site
744872000975	G3 box; other site
744872000976	Switch II region; other site
744872000977	G4 box; other site
744872000978	G5 box; other site
744872000979	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
744872000980	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
744872000981	putative peptidoglycan binding site; other site
744872000982	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107
744872000983	Peptidase family M23; Region: Peptidase_M23; pfam01551
744872000984	PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855
744872000985	putative active site [active]
744872000986	AMP-activated protein kinase (AMPK) beta subunit glycogen binding  domain (GBD). AMPK is a metabolic stress sensing protein that senses AMP/ATP and has recently been found to act as a glycogen sensor as well. The protein functions as a alpha-beta-gamma...; Region: AMPKbeta_GBD_like; cd02859
744872000987	glycogen binding site [chemical binding]; other site
744872000988	Uncharacterised ACR, COG1259; Region: DUF151; cl00553
744872000989	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
744872000990	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
744872000991	substrate binding pocket [chemical binding]; other site
744872000992	chain length determination region; other site
744872000993	substrate-Mg2+ binding site; other site
744872000994	catalytic residues [active]
744872000995	aspartate-rich region 1; other site
744872000996	active site lid residues [active]
744872000997	aspartate-rich region 2; other site
744872000998	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
744872000999	Fic/DOC family; Region: Fic; cl00960
744872001000	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
744872001001	domain; Region: Glyco_hydro_2; pfam00703
744872001002	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
744872001003	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
744872001004	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
744872001005	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872001006	dimer interface [polypeptide binding]; other site
744872001007	conserved gate region; other site
744872001008	putative PBP binding loops; other site
744872001009	ABC-ATPase subunit interface; other site
744872001010	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872001011	dimer interface [polypeptide binding]; other site
744872001012	conserved gate region; other site
744872001013	putative PBP binding loops; other site
744872001014	ABC-ATPase subunit interface; other site
744872001015	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
744872001016	Putative carbohydrate binding domain; Region: CBM_X; cl05621
744872001017	Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165
744872001018	Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205
744872001019	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
744872001020	putative catalytic site [active]
744872001021	putative metal binding site [ion binding]; other site
744872001022	putative phosphate binding site [ion binding]; other site
744872001023	FeoA domain; Region: FeoA; cl00838
744872001024	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
744872001025	Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions.  FeoB has been identified as part of this...; Region: FeoB; cd01879
744872001026	G1 box; other site
744872001027	GTP/Mg2+ binding site [chemical binding]; other site
744872001028	Switch I region; other site
744872001029	G2 box; other site
744872001030	G3 box; other site
744872001031	Switch II region; other site
744872001032	G4 box; other site
744872001033	G5 box; other site
744872001034	Nucleoside recognition; Region: Gate; cl00486
744872001035	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
744872001036	Nucleoside recognition; Region: Gate; cl00486
744872001037	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
744872001038	classical (c) SDRs; Region: SDR_c; cd05233
744872001039	NAD(P) binding site [chemical binding]; other site
744872001040	active site
744872001041	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872001042	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
744872001043	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
744872001044	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
744872001045	N-acetyl-D-glucosamine binding site [chemical binding]; other site
744872001046	catalytic residue [active]
744872001047	heat shock 70 kDa precursor protein; Provisional; Region: PTZ00186
744872001048	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
744872001049	putative peptidoglycan binding site; other site
744872001050	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872001051	binding surface
744872001052	TPR motif; other site
744872001053	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872001054	binding surface
744872001055	TPR motif; other site
744872001056	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
744872001057	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872001058	binding surface
744872001059	TPR motif; other site
744872001060	Restriction endonuclease; Region: Mrr_cat; cl00747
744872001061	RmuC family; Region: RmuC; pfam02646
744872001062	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
744872001063	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021
744872001064	dimer interface [polypeptide binding]; other site
744872001065	active site residues [active]
744872001066	SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057
744872001067	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
744872001068	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
744872001069	Walker A motif; other site
744872001070	ATP binding site [chemical binding]; other site
744872001071	Walker B motif; other site
744872001072	arginine finger; other site
744872001073	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
744872001074	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
744872001075	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
744872001076	Major Facilitator Superfamily; Region: MFS_1; pfam07690
744872001077	putative substrate translocation pore; other site
744872001078	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
744872001079	transcription termination/antitermination factor NusG; Region: nusG; TIGR00922
744872001080	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
744872001081	putative homodimer interface [polypeptide binding]; other site
744872001082	KOW motif; Region: KOW; cl00354
744872001083	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
744872001084	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
744872001085	23S rRNA interface [nucleotide binding]; other site
744872001086	L7/L12 interface [polypeptide binding]; other site
744872001087	putative thiostrepton binding site; other site
744872001088	L25 interface [polypeptide binding]; other site
744872001089	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403
744872001090	mRNA/rRNA interface [nucleotide binding]; other site
744872001091	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797
744872001092	23S rRNA interface [nucleotide binding]; other site
744872001093	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
744872001094	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
744872001095	core dimer interface [polypeptide binding]; other site
744872001096	peripheral dimer interface [polypeptide binding]; other site
744872001097	L10 interface [polypeptide binding]; other site
744872001098	L11 interface [polypeptide binding]; other site
744872001099	putative EF-Tu interaction site [polypeptide binding]; other site
744872001100	putative EF-G interaction site [polypeptide binding]; other site
744872001101	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
744872001102	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
744872001103	RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591
744872001104	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
744872001105	RPB1 interaction site [polypeptide binding]; other site
744872001106	RPB10 interaction site [polypeptide binding]; other site
744872001107	RPB11 interaction site [polypeptide binding]; other site
744872001108	RPB3 interaction site [polypeptide binding]; other site
744872001109	RPB12 interaction site [polypeptide binding]; other site
744872001110	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
744872001111	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
744872001112	RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591
744872001113	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
744872001114	DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597
744872001115	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
744872001116	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
744872001117	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
744872001118	bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603
744872001119	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
744872001120	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
744872001121	DNA binding site [nucleotide binding]
744872001122	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
744872001123	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
744872001124	S17 interaction site [polypeptide binding]; other site
744872001125	S8 interaction site; other site
744872001126	16S rRNA interaction site [nucleotide binding]; other site
744872001127	streptomycin interaction site [chemical binding]; other site
744872001128	23S rRNA interaction site [nucleotide binding]; other site
744872001129	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
744872001130	Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313
744872001131	elongation factor Tu; Reviewed; Region: PRK00049
744872001132	EF-Tu subfamily.  This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts.  It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884
744872001133	G1 box; other site
744872001134	GEF interaction site [polypeptide binding]; other site
744872001135	GTP/Mg2+ binding site [chemical binding]; other site
744872001136	Switch I region; other site
744872001137	G2 box; other site
744872001138	G3 box; other site
744872001139	Switch II region; other site
744872001140	G4 box; other site
744872001141	G5 box; other site
744872001142	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
744872001143	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707
744872001144	Antibiotic Binding Site [chemical binding]; other site
744872001145	Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314
744872001146	Ribosomal protein L3; Region: Ribosomal_L3; cl00324
744872001147	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
744872001148	Ribosomal protein L23; Region: Ribosomal_L23; cl00326
744872001149	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
744872001150	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
744872001151	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
744872001152	Ribosomal protein S19; Region: Ribosomal_S19; cl00350
744872001153	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
744872001154	putative translocon binding site; other site
744872001155	protein-rRNA interface [nucleotide binding]; other site
744872001156	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
744872001157	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The...; Region: 30S_S3_KH; cd02412
744872001158	G-X-X-G motif; other site
744872001159	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
744872001160	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
744872001161	23S rRNA interface [nucleotide binding]; other site
744872001162	5S rRNA interface [nucleotide binding]; other site
744872001163	putative antibiotic binding site [chemical binding]; other site
744872001164	L25 interface [polypeptide binding]; other site
744872001165	L27 interface [polypeptide binding]; other site
744872001166	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427
744872001167	putative translocon interaction site; other site
744872001168	23S rRNA interface [nucleotide binding]; other site
744872001169	signal recognition particle (SRP54) interaction site; other site
744872001170	L23 interface [polypeptide binding]; other site
744872001171	trigger factor interaction site; other site
744872001172	Ribosomal protein S17; Region: Ribosomal_S17; cl00351
744872001173	Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328
744872001174	KOW motif; Region: KOW; cl00354
744872001175	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
744872001176	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
744872001177	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
744872001178	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
744872001179	Ribosomal protein S8; Region: Ribosomal_S8; cl00330
744872001180	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
744872001181	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
744872001182	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
744872001183	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
744872001184	23S rRNA interface [nucleotide binding]; other site
744872001185	L21e interface [polypeptide binding]; other site
744872001186	5S rRNA interface [nucleotide binding]; other site
744872001187	L27 interface [polypeptide binding]; other site
744872001188	L5 interface [polypeptide binding]; other site
744872001189	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
744872001190	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
744872001191	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
744872001192	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658
744872001193	23S rRNA binding site [nucleotide binding]; other site
744872001194	Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022
744872001195	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
744872001196	SecY translocase; Region: SecY; pfam00344
744872001197	Ribosomal protein L36; Region: Ribosomal_L36; cl00380
744872001198	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
744872001199	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
744872001200	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
744872001201	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
744872001202	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
744872001203	RNA binding surface [nucleotide binding]; other site
744872001204	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
744872001205	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
744872001206	alphaNTD - beta interaction site [polypeptide binding]; other site
744872001207	alphaNTD homodimer interface [polypeptide binding]; other site
744872001208	alphaNTD - beta' interaction site [polypeptide binding]; other site
744872001209	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
744872001210	Ribosomal protein L17; Region: Ribosomal_L17; cl00356
744872001211	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
744872001212	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
744872001213	dimerization interface [polypeptide binding]; other site
744872001214	ligand binding site [chemical binding]; other site
744872001215	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
744872001216	TM-ABC transporter signature motif; other site
744872001217	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
744872001218	TM-ABC transporter signature motif; other site
744872001219	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
744872001220	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219
744872001221	Walker A/P-loop; other site
744872001222	ATP binding site [chemical binding]; other site
744872001223	Q-loop/lid; other site
744872001224	ABC transporter signature motif; other site
744872001225	Walker B; other site
744872001226	D-loop; other site
744872001227	H-loop/switch region; other site
744872001228	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
744872001229	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
744872001230	Walker A/P-loop; other site
744872001231	ATP binding site [chemical binding]; other site
744872001232	Q-loop/lid; other site
744872001233	ABC transporter signature motif; other site
744872001234	Walker B; other site
744872001235	D-loop; other site
744872001236	H-loop/switch region; other site
744872001237	FOG: CBS domain [General function prediction only]; Region: COG0517
744872001238	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc2; cd04585
744872001239	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141
744872001240	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
744872001241	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
744872001242	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
744872001243	synthetase active site [active]
744872001244	NTP binding site [chemical binding]; other site
744872001245	metal binding site [ion binding]; metal-binding site
744872001246	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668
744872001247	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
744872001248	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
744872001249	S-adenosylmethionine binding site [chemical binding]; other site
744872001250	peptide chain release factor 1; Validated; Region: prfA; PRK00591
744872001251	RF-1 domain; Region: RF-1; cl02875
744872001252	RF-1 domain; Region: RF-1; cl02875
744872001253	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
744872001254	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872001255	binding surface
744872001256	TPR motif; other site
744872001257	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
744872001258	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872001259	TPR motif; other site
744872001260	binding surface
744872001261	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281
744872001262	active site
744872001263	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
744872001264	putative active site [active]
744872001265	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
744872001266	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
744872001267	ring oligomerisation interface [polypeptide binding]; other site
744872001268	ATP/Mg binding site [chemical binding]; other site
744872001269	stacking interactions; other site
744872001270	hinge regions; other site
744872001271	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
744872001272	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
744872001273	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141
744872001274	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
744872001275	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
744872001276	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
744872001277	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872001278	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
744872001279	NeuB family; Region: NeuB; cl00496
744872001280	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
744872001281	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
744872001282	RNA/DNA hybrid binding site [nucleotide binding]; other site
744872001283	active site
744872001284	Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; cl01839
744872001285	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
744872001286	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424
744872001287	dimer interface [polypeptide binding]; other site
744872001288	ADP-ribose binding site [chemical binding]; other site
744872001289	active site
744872001290	nudix motif; other site
744872001291	metal binding site [ion binding]; metal-binding site
744872001292	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
744872001293	hypothetical protein; Provisional; Region: PRK13560
744872001294	putative active site [active]
744872001295	heme pocket [chemical binding]; other site
744872001296	Histidine kinase; Region: HisKA_2; cl06527
744872001297	Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG1102
744872001298	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
744872001299	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
744872001300	active site
744872001301	Zn binding site [ion binding]; other site
744872001302	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
744872001303	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
744872001304	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
744872001305	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
744872001306	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872001307	Walker A motif; other site
744872001308	ATP binding site [chemical binding]; other site
744872001309	Walker B motif; other site
744872001310	Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase).  The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA.  This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886
744872001311	elongation factor G; Reviewed; Region: PRK12740
744872001312	G1 box; other site
744872001313	putative GEF interaction site [polypeptide binding]; other site
744872001314	GTP/Mg2+ binding site [chemical binding]; other site
744872001315	Switch I region; other site
744872001316	G2 box; other site
744872001317	G3 box; other site
744872001318	Switch II region; other site
744872001319	G4 box; other site
744872001320	G5 box; other site
744872001321	mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091
744872001322	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434
744872001323	mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_C; cd04097
744872001324	Sporulation related domain; Region: SPOR; cl10051
744872001325	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
744872001326	CoA-binding site [chemical binding]; other site
744872001327	ATP-binding [chemical binding]; other site
744872001328	5'-3' exonuclease; Region: 53EXOc; smart00475
744872001329	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
744872001330	active site
744872001331	metal binding site 1 [ion binding]; metal-binding site
744872001332	putative 5' ssDNA interaction site; other site
744872001333	metal binding site 3; metal-binding site
744872001334	metal binding site 2 [ion binding]; metal-binding site
744872001335	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
744872001336	putative DNA binding site [nucleotide binding]; other site
744872001337	putative metal binding site [ion binding]; other site
744872001338	DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749
744872001339	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
744872001340	active site
744872001341	catalytic site [active]
744872001342	substrate binding site [chemical binding]; other site
744872001343	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
744872001344	active site
744872001345	DNA binding site [nucleotide binding]
744872001346	catalytic site [active]
744872001347	FlgN protein; Region: FlgN; cl09176
744872001348	Flagellar protein FliS; Region: FliS; cl00654
744872001349	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
744872001350	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
744872001351	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
744872001352	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
744872001353	dimer interface [polypeptide binding]; other site
744872001354	active site
744872001355	Mechanosensitive ion channel; Region: MS_channel; pfam00924
744872001356	FtsH Extracellular; Region: FtsH_ext; pfam06480
744872001357	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
744872001358	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
744872001359	Walker A motif; other site
744872001360	ATP binding site [chemical binding]; other site
744872001361	Walker B motif; other site
744872001362	arginine finger; other site
744872001363	Peptidase family M41; Region: Peptidase_M41; pfam01434
744872001364	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
744872001365	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663
744872001366	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065
744872001367	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
744872001368	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258
744872001369	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
744872001370	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
744872001371	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
744872001372	FeS/SAM binding site; other site
744872001373	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
744872001374	UvrD/REP helicase; Region: UvrD-helicase; cl14126
744872001375	UvrD/REP helicase; Region: UvrD-helicase; cl14126
744872001376	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
744872001377	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
744872001378	23S rRNA interface [nucleotide binding]; other site
744872001379	L3 interface [polypeptide binding]; other site
744872001380	Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334
744872001381	RecX family; Region: RecX; cl00936
744872001382	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
744872001383	DNA binding residues [nucleotide binding]
744872001384	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872001385	active site
744872001386	phosphorylation site [posttranslational modification]
744872001387	intermolecular recognition site; other site
744872001388	dimerization interface [polypeptide binding]; other site
744872001389	Response regulator receiver domain; Region: Response_reg; pfam00072
744872001390	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872001391	active site
744872001392	phosphorylation site [posttranslational modification]
744872001393	intermolecular recognition site; other site
744872001394	dimerization interface [polypeptide binding]; other site
744872001395	Acylphosphatase; Region: Acylphosphatase; cl00551
744872001396	S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802
744872001397	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
744872001398	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
744872001399	anti sigma factor interaction site; other site
744872001400	regulatory phosphorylation site [posttranslational modification]; other site
744872001401	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141
744872001402	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
744872001403	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
744872001404	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
744872001405	metal binding site [ion binding]; metal-binding site
744872001406	active site
744872001407	I-site; other site
744872001408	Uncharacterised protein family UPF0102; Region: UPF0102; cl00516
744872001409	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
744872001410	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
744872001411	Zn2+ binding site [ion binding]; other site
744872001412	Mg2+ binding site [ion binding]; other site
744872001413	Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017
744872001414	Ribosomal protein L19; Region: Ribosomal_L19; cl00406
744872001415	tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407
744872001416	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
744872001417	RimM N-terminal domain; Region: RimM; pfam01782
744872001418	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837; cl00794
744872001419	Ribosomal protein S16; Region: Ribosomal_S16; cl00368
744872001420	signal recognition particle protein; Provisional; Region: PRK10867
744872001421	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
744872001422	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
744872001423	P loop; other site
744872001424	GTP binding site [chemical binding]; other site
744872001425	Signal peptide binding domain; Region: SRP_SPB; pfam02978
744872001426	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
744872001427	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872001428	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
744872001429	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
744872001430	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607
744872001431	active site
744872001432	Zn binding site [ion binding]; other site
744872001433	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
744872001434	active site
744872001435	multimer interface [polypeptide binding]; other site
744872001436	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
744872001437	PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570
744872001438	dimerization interface 3.5A [polypeptide binding]; other site
744872001439	active site
744872001440	tryptophanyl-tRNA synthetase; Region: trpS; TIGR00233
744872001441	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
744872001442	active site
744872001443	HIGH motif; other site
744872001444	dimer interface [polypeptide binding]; other site
744872001445	KMSKS motif; other site
744872001446	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
744872001447	active site
744872001448	metal binding site [ion binding]; metal-binding site
744872001449	homotetramer interface [polypeptide binding]; other site
744872001450	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
744872001451	Response regulator receiver domain; Region: Response_reg; pfam00072
744872001452	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872001453	active site
744872001454	phosphorylation site [posttranslational modification]
744872001455	intermolecular recognition site; other site
744872001456	dimerization interface [polypeptide binding]; other site
744872001457	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
744872001458	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
744872001459	ATP binding site [chemical binding]; other site
744872001460	putative Mg++ binding site [ion binding]; other site
744872001461	Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571
744872001462	Mg++ binding site [ion binding]; other site
744872001463	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872001464	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
744872001465	active site
744872001466	NTP binding site [chemical binding]; other site
744872001467	metal binding triad [ion binding]; metal-binding site
744872001468	antibiotic binding site [chemical binding]; other site
744872001469	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
744872001470	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
744872001471	NAD binding site [chemical binding]; other site
744872001472	substrate binding site [chemical binding]; other site
744872001473	active site
744872001474	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
744872001475	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
744872001476	inhibitor-cofactor binding pocket; inhibition site
744872001477	pyridoxal 5'-phosphate binding site [chemical binding]; other site
744872001478	catalytic residue [active]
744872001479	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
744872001480	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
744872001481	putative trimer interface [polypeptide binding]; other site
744872001482	putative CoA binding site [chemical binding]; other site
744872001483	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
744872001484	NeuB family; Region: NeuB; cl00496
744872001485	SAF domain; Region: SAF; cl00555
744872001486	UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568
744872001487	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues...; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
744872001488	active site
744872001489	homodimer interface [polypeptide binding]; other site
744872001490	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607
744872001491	NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426
744872001492	Substrate binding site [chemical binding]; other site
744872001493	metal binding site [ion binding]; metal-binding site
744872001494	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872001495	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
744872001496	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
744872001497	ligand binding site [chemical binding]; other site
744872001498	tetramer interface [polypeptide binding]; other site
744872001499	flagellin modification protein A; Provisional; Region: PRK09186
744872001500	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872001501	NAD(P) binding site [chemical binding]; other site
744872001502	active site
744872001503	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
744872001504	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This...; Region: Alpha_ANH_like_III; cd01996
744872001505	Ligand Binding Site [chemical binding]; other site
744872001506	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181
744872001507	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
744872001508	putative active site [active]
744872001509	oxyanion strand; other site
744872001510	catalytic triad [active]
744872001511	Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107
744872001512	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731
744872001513	substrate binding site [chemical binding]; other site
744872001514	glutamase interaction surface [polypeptide binding]; other site
744872001515	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
744872001516	Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719
744872001517	NAD(P) binding site [chemical binding]; other site
744872001518	homodimer interface [polypeptide binding]; other site
744872001519	substrate binding site [chemical binding]; other site
744872001520	active site
744872001521	Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
744872001522	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872001523	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
744872001524	NAD(P) binding site [chemical binding]; other site
744872001525	active site
744872001526	Cupin domain; Region: Cupin_2; cl09118
744872001527	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
744872001528	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues...; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
744872001529	active site
744872001530	homodimer interface [polypeptide binding]; other site
744872001531	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
744872001532	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
744872001533	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
744872001534	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
744872001535	substrate binding site [chemical binding]; other site
744872001536	tetramer interface [polypeptide binding]; other site
744872001537	Cupin domain; Region: Cupin_2; cl09118
744872001538	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
744872001539	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
744872001540	NADP binding site [chemical binding]; other site
744872001541	active site
744872001542	putative substrate binding site [chemical binding]; other site
744872001543	Phd_YefM; Region: PhdYeFM; cl09153
744872001544	Phd_YefM; Region: PhdYeFM; cl09153
744872001545	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
744872001546	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
744872001547	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
744872001548	NAD binding site [chemical binding]; other site
744872001549	substrate binding site [chemical binding]; other site
744872001550	homodimer interface [polypeptide binding]; other site
744872001551	active site
744872001552	Protein of unknown function DUF262; Region: DUF262; cl14890
744872001553	Protein of unknown function DUF262; Region: DUF262; cl14890
744872001554	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483
744872001555	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
744872001556	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872001557	Walker A/P-loop; other site
744872001558	ATP binding site [chemical binding]; other site
744872001559	Q-loop/lid; other site
744872001560	ABC transporter signature motif; other site
744872001561	Walker B; other site
744872001562	D-loop; other site
744872001563	H-loop/switch region; other site
744872001564	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215
744872001565	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
744872001566	TM-ABC transporter signature motif; other site
744872001567	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
744872001568	TM-ABC transporter signature motif; other site
744872001569	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
744872001570	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
744872001571	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
744872001572	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
744872001573	DbpA RNA binding domain; Region: DbpA; pfam03880
744872001574	Uncharacterised protein family (UPF0158); Region: UPF0158; pfam03682
744872001575	enolase; Provisional; Region: eno; PRK00077
744872001576	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
744872001577	dimer interface [polypeptide binding]; other site
744872001578	metal binding site [ion binding]; metal-binding site
744872001579	substrate binding pocket [chemical binding]; other site
744872001580	Chromate transporter; Region: Chromate_transp; pfam02417
744872001581	Chromate transporter; Region: Chromate_transp; pfam02417
744872001582	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
744872001583	Histidine kinase; Region: HisKA_2; cl06527
744872001584	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872001585	ATP binding site [chemical binding]; other site
744872001586	Mg2+ binding site [ion binding]; other site
744872001587	G-X-G motif; other site
744872001588	UbiA prenyltransferase family; Region: UbiA; cl00337
744872001589	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
744872001590	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
744872001591	substrate binding pocket [chemical binding]; other site
744872001592	membrane-bound complex binding site; other site
744872001593	hinge residues; other site
744872001594	PAS fold; Region: PAS_4; pfam08448
744872001595	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
744872001596	Histidine kinase; Region: HisKA_2; cl06527
744872001597	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872001598	ATP binding site [chemical binding]; other site
744872001599	Mg2+ binding site [ion binding]; other site
744872001600	G-X-G motif; other site
744872001601	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
744872001602	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
744872001603	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
744872001604	CoA enzyme activase uncharacterised domain (DUF2229); Region: DUF2229; cl12083
744872001605	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
744872001606	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
744872001607	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
744872001608	active site
744872001609	nucleophile elbow; other site
744872001610	serine O-acetyltransferase; Region: cysE; TIGR01172
744872001611	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354
744872001612	trimer interface [polypeptide binding]; other site
744872001613	active site
744872001614	substrate binding site [chemical binding]; other site
744872001615	CoA binding site [chemical binding]; other site
744872001616	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
744872001617	GTPase Era; Reviewed; Region: era; PRK00089
744872001618	Era subfamily.  Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria.  It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163
744872001619	G1 box; other site
744872001620	GTP/Mg2+ binding site [chemical binding]; other site
744872001621	Switch I region; other site
744872001622	G2 box; other site
744872001623	Switch II region; other site
744872001624	G3 box; other site
744872001625	G4 box; other site
744872001626	G5 box; other site
744872001627	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098
744872001628	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
744872001629	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
744872001630	seryl-tRNA synthetase; Provisional; Region: PRK05431
744872001631	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
744872001632	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
744872001633	dimer interface [polypeptide binding]; other site
744872001634	active site
744872001635	motif 1; other site
744872001636	motif 2; other site
744872001637	motif 3; other site
744872001638	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
744872001639	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
744872001640	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
744872001641	oligomeric interface; other site
744872001642	putative active site [active]
744872001643	homodimer interface [polypeptide binding]; other site
744872001644	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
744872001645	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278
744872001646	Walker A/P-loop; other site
744872001647	ATP binding site [chemical binding]; other site
744872001648	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
744872001649	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278
744872001650	Q-loop/lid; other site
744872001651	ABC transporter signature motif; other site
744872001652	Walker B; other site
744872001653	D-loop; other site
744872001654	H-loop/switch region; other site
744872001655	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
744872001656	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
744872001657	oligomeric interface; other site
744872001658	putative active site [active]
744872001659	homodimer interface [polypeptide binding]; other site
744872001660	Staphylococcal nuclease homologues; Region: SNc; smart00318
744872001661	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
744872001662	Catalytic site; other site
744872001663	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
744872001664	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872001665	Walker A/P-loop; other site
744872001666	ATP binding site [chemical binding]; other site
744872001667	Q-loop/lid; other site
744872001668	ABC transporter signature motif; other site
744872001669	Walker B; other site
744872001670	D-loop; other site
744872001671	H-loop/switch region; other site
744872001672	ABC transporter; Region: ABC_tran_2; pfam12848
744872001673	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
744872001674	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04537
744872001675	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif (...; Region: DEADc; cd00268
744872001676	ATP binding site [chemical binding]; other site
744872001677	Mg++ binding site [ion binding]; other site
744872001678	motif III; other site
744872001679	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
744872001680	nucleotide binding region [chemical binding]; other site
744872001681	ATP-binding site [chemical binding]; other site
744872001682	diacylglycerol glucosyltransferase; Provisional; Region: PRK13609
744872001683	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
744872001684	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
744872001685	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
744872001686	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464
744872001687	putative dimer interface [polypeptide binding]; other site
744872001688	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
744872001689	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464
744872001690	putative dimer interface [polypeptide binding]; other site
744872001691	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293
744872001692	B12 binding site [chemical binding]; other site
744872001693	Radical SAM; Region: Elp3; smart00729
744872001694	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
744872001695	FeS/SAM binding site; other site
744872001696	Voltage gated chloride channel; Region: Voltage_CLC; pfam00654
744872001697	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-...; Region: EriC; cd01031
744872001698	Cl- selectivity filter; other site
744872001699	Cl- binding residues [ion binding]; other site
744872001700	pore gating glutamate residue; other site
744872001701	dimer interface [polypeptide binding]; other site
744872001702	H+/Cl- coupling transport residue; other site
744872001703	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
744872001704	Mo-co oxidoreductase dimerisation domain; Region: Mo-co_dimer; pfam03404
744872001705	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
744872001706	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
744872001707	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
744872001708	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
744872001709	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
744872001710	PilZ domain; Region: PilZ; cl01260
744872001711	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
744872001712	non-specific DNA binding site [nucleotide binding]; other site
744872001713	salt bridge; other site
744872001714	sequence-specific DNA binding site [nucleotide binding]; other site
744872001715	Cupin domain; Region: Cupin_2; cl09118
744872001716	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
744872001717	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550
744872001718	ABC-ATPase subunit  interface; other site
744872001719	putative PBP binding regions; other site
744872001720	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262
744872001721	intersubunit interface [polypeptide binding]; other site
744872001722	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262
744872001723	probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172
744872001724	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
744872001725	metal coordination site [ion binding]; other site
744872001726	Uncharacterized conserved protein [Function unknown]; Region: COG0327
744872001727	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412
744872001728	Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061
744872001729	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
744872001730	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
744872001731	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872001732	dimer interface [polypeptide binding]; other site
744872001733	conserved gate region; other site
744872001734	ABC-ATPase subunit interface; other site
744872001735	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872001736	dimer interface [polypeptide binding]; other site
744872001737	conserved gate region; other site
744872001738	putative PBP binding loops; other site
744872001739	ABC-ATPase subunit interface; other site
744872001740	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
744872001741	mannonate dehydratase; Provisional; Region: PRK03906
744872001742	mannonate dehydratase; Region: uxuA; TIGR00695
744872001743	Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661
744872001744	Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648
744872001745	Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477
744872001746	Probable beta-xylosidase; Provisional; Region: PLN03080
744872001747	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
744872001748	Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915
744872001749	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872001750	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
744872001751	NAD(P) binding site [chemical binding]; other site
744872001752	active site
744872001753	Transcriptional regulators [Transcription]; Region: GntR; COG1802
744872001754	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
744872001755	DNA-binding site [nucleotide binding]; DNA binding site
744872001756	FCD domain; Region: FCD; cl11656
744872001757	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
744872001758	putative active site [active]
744872001759	membrane protein FdrA; Validated; Region: PRK06091
744872001760	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872001761	membrane protein FdrA; Validated; Region: PRK06091
744872001762	Protein of unknown function (DUF1116); Region: DUF1116; pfam06545
744872001763	Putative cyclase; Region: Cyclase; cl00814
744872001764	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
744872001765	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829
744872001766	active site
744872001767	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
744872001768	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
744872001769	Transcriptional regulators [Transcription]; Region: GntR; COG1802
744872001770	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
744872001771	DNA-binding site [nucleotide binding]; DNA binding site
744872001772	FCD domain; Region: FCD; cl11656
744872001773	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
744872001774	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390
744872001775	Permease family; Region: Xan_ur_permease; pfam00860
744872001776	Sulfate transporter family; Region: Sulfate_transp; cl00967
744872001777	Cupin domain; Region: Cupin_2; cl09118
744872001778	Pectinesterase; Region: Pectinesterase; cl01911
744872001779	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
744872001780	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
744872001781	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872001782	dimer interface [polypeptide binding]; other site
744872001783	conserved gate region; other site
744872001784	putative PBP binding loops; other site
744872001785	ABC-ATPase subunit interface; other site
744872001786	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872001787	dimer interface [polypeptide binding]; other site
744872001788	conserved gate region; other site
744872001789	putative PBP binding loops; other site
744872001790	ABC-ATPase subunit interface; other site
744872001791	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
744872001792	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402
744872001793	active site
744872001794	catalytic site [active]
744872001795	Transcriptional regulators [Transcription]; Region: PurR; COG1609
744872001796	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
744872001797	DNA binding site [nucleotide binding]
744872001798	domain linker motif; other site
744872001799	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
744872001800	dimerization interface [polypeptide binding]; other site
744872001801	ligand binding site [chemical binding]; other site
744872001802	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
744872001803	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
744872001804	active site
744872001805	intersubunit interface [polypeptide binding]; other site
744872001806	catalytic residue [active]
744872001807	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
744872001808	substrate binding site [chemical binding]; other site
744872001809	ATP binding site [chemical binding]; other site
744872001810	KduI/IolB family; Region: KduI; cl01508
744872001811	2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832
744872001812	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
744872001813	NADP binding site [chemical binding]; other site
744872001814	homodimer interface [polypeptide binding]; other site
744872001815	active site
744872001816	DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090
744872001817	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
744872001818	Bacterial transcriptional regulator; Region: IclR; pfam01614
744872001819	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
744872001820	Glucuronate isomerase; Region: UxaC; cl00829
744872001821	Membrane transport protein; Region: Mem_trans; cl09117
744872001822	bile acid transporter; Region: bass; TIGR00841
744872001823	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
744872001824	ligand binding site [chemical binding]; other site
744872001825	Protein of unknown function (DUF1390); Region: DUF1390; pfam07150
744872001826	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
744872001827	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
744872001828	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
744872001829	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
744872001830	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
744872001831	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
744872001832	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872001833	dimer interface [polypeptide binding]; other site
744872001834	conserved gate region; other site
744872001835	putative PBP binding loops; other site
744872001836	ABC-ATPase subunit interface; other site
744872001837	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
744872001838	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
744872001839	parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805
744872001840	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
744872001841	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060
744872001842	Metal-binding active site; metal-binding site
744872001843	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872001844	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
744872001845	Membrane transport protein; Region: Mem_trans; cl09117
744872001846	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
744872001847	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
744872001848	Walker A motif; other site
744872001849	ATP binding site [chemical binding]; other site
744872001850	Walker B motif; other site
744872001851	ferredoxin; Validated; Region: PRK07118
744872001852	Putative Fe-S cluster; Region: FeS; pfam04060
744872001853	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
744872001854	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
744872001855	FMN-binding domain; Region: FMN_bind; cl01081
744872001856	RnfE family; Region: NQR2_RnfD_RnfE; cl00779
744872001857	C subunit; Region: rnfC; TIGR01945
744872001858	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
744872001859	AzlC protein; Region: AzlC; cl00570
744872001860	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
744872001861	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
744872001862	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
744872001863	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017
744872001864	catalytic triad [active]
744872001865	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
744872001866	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
744872001867	active site
744872001868	HIGH motif; other site
744872001869	nucleotide binding site [chemical binding]; other site
744872001870	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
744872001871	KMSKS motif; other site
744872001872	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
744872001873	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
744872001874	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
744872001875	dimer interface [polypeptide binding]; other site
744872001876	active site
744872001877	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
744872001878	catalytic residues [active]
744872001879	substrate binding site [chemical binding]; other site
744872001880	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204
744872001881	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
744872001882	active site
744872001883	ADP/pyrophosphate binding site [chemical binding]; other site
744872001884	dimerization interface [polypeptide binding]; other site
744872001885	allosteric effector site; other site
744872001886	fructose-1,6-bisphosphate binding site; other site
744872001887	AAK_UMPK-PyrH-Pf: UMP kinase (UMPK)-Pf, the mostly archaeal uridine monophosphate kinase (uridylate kinase) enzymes that catalyze UMP phosphorylation and play a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back...; Region: AAK_UMPK-PyrH-Pf; cd04253
744872001888	nucleotide binding site [chemical binding]; other site
744872001889	homodimeric interface [polypeptide binding]; other site
744872001890	uridine monophosphate binding site [chemical binding]; other site
744872001891	E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies.  These domains are associated with different types of catalytic domains at  either the N-terminal or C-terminal end; Region: E_set; cl09101
744872001892	E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies.  These domains are associated with different types of catalytic domains at  either the N-terminal or C-terminal end; Region: E_set; cl09101
744872001893	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
744872001894	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl11829
744872001895	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
744872001896	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
744872001897	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
744872001898	DNA binding residues [nucleotide binding]
744872001899	cysteinyl-tRNA synthetase; Provisional; Region: cysS; PRK14536
744872001900	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
744872001901	active site
744872001902	HIGH motif; other site
744872001903	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
744872001904	KMSKS motif; other site
744872001905	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
744872001906	tRNA binding surface [nucleotide binding]; other site
744872001907	anticodon binding site; other site
744872001908	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
744872001909	FAD binding domain; Region: FAD_binding_4; pfam01565
744872001910	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
744872001911	FecR protein; Region: FecR; pfam04773
744872001912	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
744872001913	ligand binding site [chemical binding]; other site
744872001914	flexible hinge region; other site
744872001915	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
744872001916	ligand binding site [chemical binding]; other site
744872001917	flexible hinge region; other site
744872001918	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192
744872001919	Uncharacterized ACR, COG1430; Region: DUF192; cl00627
744872001920	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
744872001921	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872001922	TPR motif; other site
744872001923	binding surface
744872001924	PilZ domain; Region: PilZ; cl01260
744872001925	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
744872001926	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
744872001927	active site
744872001928	metal binding site [ion binding]; metal-binding site
744872001929	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743
744872001930	hypothetical protein; Reviewed; Region: PRK00024
744872001931	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
744872001932	MPN+ (JAMM) motif; other site
744872001933	Zinc-binding site [ion binding]; other site
744872001934	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
744872001935	Ferritin-like domain; Region: Ferritin; pfam00210
744872001936	ferroxidase diiron center [ion binding]; other site
744872001937	PEGA domain; Region: PEGA; pfam08308
744872001938	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
744872001939	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-...; Region: KBL_like; cd06454
744872001940	substrate-cofactor binding pocket; other site
744872001941	pyridoxal 5'-phosphate binding site [chemical binding]; other site
744872001942	catalytic residue [active]
744872001943	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258
744872001944	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme; Region: NifX_NifB; cl00252
744872001945	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149
744872001946	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987
744872001947	protein binding site [polypeptide binding]; other site
744872001948	FecR protein; Region: FecR; pfam04773
744872001949	FOG: WD40-like repeat [Function unknown]; Region: COG1520
744872001950	Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493
744872001951	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
744872001952	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
744872001953	Domain of unknown function DUF77; Region: DUF77; cl00307
744872001954	Cobalt transport protein; Region: CbiQ; cl00463
744872001955	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
744872001956	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This...; Region: ABC_cobalt_CbiO_domain1; cd03225
744872001957	Walker A/P-loop; other site
744872001958	ATP binding site [chemical binding]; other site
744872001959	Q-loop/lid; other site
744872001960	ABC transporter signature motif; other site
744872001961	Walker B; other site
744872001962	D-loop; other site
744872001963	H-loop/switch region; other site
744872001964	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This...; Region: ABC_cobalt_CbiO_domain1; cd03225
744872001965	Walker A/P-loop; other site
744872001966	ATP binding site [chemical binding]; other site
744872001967	Q-loop/lid; other site
744872001968	ABC transporter signature motif; other site
744872001969	Walker B; other site
744872001970	D-loop; other site
744872001971	H-loop/switch region; other site
744872001972	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943
744872001973	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
744872001974	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
744872001975	putative active site [active]
744872001976	heme pocket [chemical binding]; other site
744872001977	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
744872001978	dimer interface [polypeptide binding]; other site
744872001979	phosphorylation site [posttranslational modification]
744872001980	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872001981	ATP binding site [chemical binding]; other site
744872001982	Mg2+ binding site [ion binding]; other site
744872001983	G-X-G motif; other site
744872001984	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
744872001985	anti sigma factor interaction site; other site
744872001986	regulatory phosphorylation site [posttranslational modification]; other site
744872001987	Response regulator receiver domain; Region: Response_reg; pfam00072
744872001988	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872001989	active site
744872001990	phosphorylation site [posttranslational modification]
744872001991	intermolecular recognition site; other site
744872001992	dimerization interface [polypeptide binding]; other site
744872001993	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
744872001994	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This...; Region: ABC_cobalt_CbiO_domain1; cd03225
744872001995	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
744872001996	Walker A/P-loop; other site
744872001997	ATP binding site [chemical binding]; other site
744872001998	Q-loop/lid; other site
744872001999	ABC transporter signature motif; other site
744872002000	Walker B; other site
744872002001	D-loop; other site
744872002002	H-loop/switch region; other site
744872002003	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634
744872002004	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This...; Region: ABC_cobalt_CbiO_domain1; cd03225
744872002005	Walker A/P-loop; other site
744872002006	ATP binding site [chemical binding]; other site
744872002007	Q-loop/lid; other site
744872002008	ABC transporter signature motif; other site
744872002009	Walker B; other site
744872002010	D-loop; other site
744872002011	H-loop/switch region; other site
744872002012	Cobalt transport protein; Region: CbiQ; cl00463
744872002013	Predicted membrane protein [Function unknown]; Region: COG4684
744872002014	Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130
744872002015	Protein of unknown function (DUF2703); Region: DUF2703; pfam10865
744872002016	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
744872002017	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
744872002018	motif II; other site
744872002019	Ferritin-like domain; Region: Ferritin; pfam00210
744872002020	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
744872002021	dimerization interface [polypeptide binding]; other site
744872002022	DPS ferroxidase diiron center [ion binding]; other site
744872002023	ion pore; other site
744872002024	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323
744872002025	C4-dicarboxylate transporter/malic acid transport protein; Region: C4dic_mal_tran; pfam03595
744872002026	gating phenylalanine in ion channel; other site
744872002027	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme; Region: NifX_NifB; cl00252
744872002028	This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110
744872002029	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
744872002030	switch II; other site
744872002031	4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family; Region: Fer4_NifH; pfam00142
744872002032	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme; Region: NifX_NifB; cl00252
744872002033	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
744872002034	This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110
744872002035	switch II; other site
744872002036	PAS fold; Region: PAS_4; pfam08448
744872002037	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
744872002038	putative active site [active]
744872002039	heme pocket [chemical binding]; other site
744872002040	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
744872002041	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
744872002042	Walker A motif; other site
744872002043	ATP binding site [chemical binding]; other site
744872002044	Walker B motif; other site
744872002045	arginine finger; other site
744872002046	Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
744872002047	peroxiredoxin; Provisional; Region: PRK13189
744872002048	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
744872002049	dimer interface [polypeptide binding]; other site
744872002050	decamer (pentamer of dimers) interface [polypeptide binding]; other site
744872002051	catalytic triad [active]
744872002052	GAF domain; Region: GAF; cl00853
744872002053	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
744872002054	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
744872002055	Walker A motif; other site
744872002056	ATP binding site [chemical binding]; other site
744872002057	Walker B motif; other site
744872002058	arginine finger; other site
744872002059	Acetokinase family; Region: Acetate_kinase; cl01029
744872002060	Rv0623-like transcription factor; Region: PSK_trans_fac; cl01834
744872002061	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
744872002062	putative active site [active]
744872002063	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
744872002064	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
744872002065	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
744872002066	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872002067	dimer interface [polypeptide binding]; other site
744872002068	putative PBP binding loops; other site
744872002069	ABC-ATPase subunit interface; other site
744872002070	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
744872002071	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
744872002072	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
744872002073	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412
744872002074	Transposase domain (DUF772); Region: DUF772; cl12084
744872002075	Predicted transcriptional regulator [Transcription]; Region: COG4189
744872002076	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
744872002077	dimerization interface [polypeptide binding]; other site
744872002078	putative DNA binding site [nucleotide binding]; other site
744872002079	putative Zn2+ binding site [ion binding]; other site
744872002080	Integrase core domain; Region: rve; cl01316
744872002081	Uncharacterised protein family UPF0047; Region: UPF0047; cl00439
744872002082	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
744872002083	oligoendopeptidase F; Region: pepF; TIGR00181
744872002084	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
744872002085	active site
744872002086	Zn binding site [ion binding]; other site
744872002087	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH...; Region: alkPPc; cl12039
744872002088	dimer interface [polypeptide binding]; other site
744872002089	Alkaline phosphatase homologues; Region: alkPPc; smart00098
744872002090	active site
744872002091	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH...; Region: alkPPc; cl12039
744872002092	YibE/F-like protein; Region: YibE_F; cl02259
744872002093	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
744872002094	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
744872002095	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
744872002096	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872002097	putative PBP binding loops; other site
744872002098	dimer interface [polypeptide binding]; other site
744872002099	ABC-ATPase subunit interface; other site
744872002100	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
744872002101	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872002102	dimer interface [polypeptide binding]; other site
744872002103	conserved gate region; other site
744872002104	putative PBP binding loops; other site
744872002105	ABC-ATPase subunit interface; other site
744872002106	Transcriptional regulators [Transcription]; Region: PurR; COG1609
744872002107	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
744872002108	DNA binding site [nucleotide binding]
744872002109	domain linker motif; other site
744872002110	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
744872002111	ligand binding site [chemical binding]; other site
744872002112	dimerization interface [polypeptide binding]; other site
744872002113	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
744872002114	Protein export membrane protein; Region: SecD_SecF; cl14618
744872002115	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
744872002116	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
744872002117	E3 interaction surface; other site
744872002118	lipoyl attachment site [posttranslational modification]; other site
744872002119	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
744872002120	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
744872002121	Outer membrane efflux protein; Region: OEP; pfam02321
744872002122	Outer membrane efflux protein; Region: OEP; pfam02321
744872002123	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
744872002124	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872002125	active site
744872002126	phosphorylation site [posttranslational modification]
744872002127	intermolecular recognition site; other site
744872002128	dimerization interface [polypeptide binding]; other site
744872002129	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
744872002130	DNA binding site [nucleotide binding]
744872002131	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225
744872002132	dimerization interface [polypeptide binding]; other site
744872002133	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
744872002134	dimer interface [polypeptide binding]; other site
744872002135	phosphorylation site [posttranslational modification]
744872002136	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872002137	ATP binding site [chemical binding]; other site
744872002138	Mg2+ binding site [ion binding]; other site
744872002139	G-X-G motif; other site
744872002140	Transcriptional regulators [Transcription]; Region: PurR; COG1609
744872002141	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
744872002142	DNA binding site [nucleotide binding]
744872002143	domain linker motif; other site
744872002144	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
744872002145	dimerization interface [polypeptide binding]; other site
744872002146	ligand binding site [chemical binding]; other site
744872002147	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
744872002148	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
744872002149	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872002150	dimer interface [polypeptide binding]; other site
744872002151	conserved gate region; other site
744872002152	putative PBP binding loops; other site
744872002153	ABC-ATPase subunit interface; other site
744872002154	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
744872002155	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872002156	dimer interface [polypeptide binding]; other site
744872002157	conserved gate region; other site
744872002158	putative PBP binding loops; other site
744872002159	ABC-ATPase subunit interface; other site
744872002160	putative alpha-glucosidase; Provisional; Region: PRK10658
744872002161	YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593
744872002162	active site
744872002163	homotrimer interface [polypeptide binding]; other site
744872002164	catalytic site [active]
744872002165	homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site
744872002166	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
744872002167	active site
744872002168	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
744872002169	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
744872002170	active site
744872002171	catalytic tetrad [active]
744872002172	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
744872002173	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
744872002174	dimer interface [polypeptide binding]; other site
744872002175	phosphorylation site [posttranslational modification]
744872002176	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872002177	ATP binding site [chemical binding]; other site
744872002178	Mg2+ binding site [ion binding]; other site
744872002179	G-X-G motif; other site
744872002180	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
744872002181	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872002182	active site
744872002183	phosphorylation site [posttranslational modification]
744872002184	intermolecular recognition site; other site
744872002185	dimerization interface [polypeptide binding]; other site
744872002186	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
744872002187	DNA binding residues [nucleotide binding]
744872002188	dimerization interface [polypeptide binding]; other site
744872002189	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
744872002190	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
744872002191	active site
744872002192	metal binding site [ion binding]; metal-binding site
744872002193	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
744872002194	active site
744872002195	metal binding site [ion binding]; metal-binding site
744872002196	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
744872002197	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
744872002198	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
744872002199	Major Facilitator Superfamily; Region: MFS_1; pfam07690
744872002200	putative substrate translocation pore; other site
744872002201	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
744872002202	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
744872002203	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872002204	Walker A/P-loop; other site
744872002205	ATP binding site [chemical binding]; other site
744872002206	Q-loop/lid; other site
744872002207	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
744872002208	ABC transporter signature motif; other site
744872002209	Walker B; other site
744872002210	D-loop; other site
744872002211	ABC transporter; Region: ABC_tran_2; pfam12848
744872002212	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
744872002213	peptide chain release factor 1; Validated; Region: prfA; PRK00591
744872002214	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
744872002215	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
744872002216	NAD binding site [chemical binding]; other site
744872002217	homodimer interface [polypeptide binding]; other site
744872002218	active site
744872002219	substrate binding site [chemical binding]; other site
744872002220	diaminopimelate aminotransferase; Provisional; Region: PRK13983
744872002221	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like1; cd05650
744872002222	metal binding site [ion binding]; metal-binding site
744872002223	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
744872002224	GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807
744872002225	dimerization interface [polypeptide binding]; other site
744872002226	active site
744872002227	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
744872002228	FeS/SAM binding site; other site
744872002229	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
744872002230	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
744872002231	active site
744872002232	nucleotide binding site [chemical binding]; other site
744872002233	HIGH motif; other site
744872002234	KMSKS motif; other site
744872002235	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
744872002236	ligand binding site [chemical binding]; other site
744872002237	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
744872002238	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216
744872002239	Walker A/P-loop; other site
744872002240	ATP binding site [chemical binding]; other site
744872002241	Q-loop/lid; other site
744872002242	ABC transporter signature motif; other site
744872002243	Walker B; other site
744872002244	D-loop; other site
744872002245	H-loop/switch region; other site
744872002246	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215
744872002247	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580
744872002248	TM-ABC transporter signature motif; other site
744872002249	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580
744872002250	TM-ABC transporter signature motif; other site
744872002251	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
744872002252	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
744872002253	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
744872002254	dimer interface [polypeptide binding]; other site
744872002255	FMN binding site [chemical binding]; other site
744872002256	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
744872002257	metal binding site 2 [ion binding]; metal-binding site
744872002258	putative DNA binding helix; other site
744872002259	metal binding site 1 [ion binding]; metal-binding site
744872002260	dimer interface [polypeptide binding]; other site
744872002261	structural Zn2+ binding site [ion binding]; other site
744872002262	Transcriptional regulators [Transcription]; Region: PurR; COG1609
744872002263	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
744872002264	DNA binding site [nucleotide binding]
744872002265	domain linker motif; other site
744872002266	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
744872002267	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
744872002268	active site
744872002269	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
744872002270	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
744872002271	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
744872002272	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
744872002273	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
744872002274	dimer interface [polypeptide binding]; other site
744872002275	phosphorylation site [posttranslational modification]
744872002276	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872002277	ATP binding site [chemical binding]; other site
744872002278	Mg2+ binding site [ion binding]; other site
744872002279	G-X-G motif; other site
744872002280	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
744872002281	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872002282	active site
744872002283	phosphorylation site [posttranslational modification]
744872002284	intermolecular recognition site; other site
744872002285	dimerization interface [polypeptide binding]; other site
744872002286	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
744872002287	DNA binding site [nucleotide binding]
744872002288	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
744872002289	PhoU domain; Region: PhoU; pfam01895
744872002290	PhoU domain; Region: PhoU; pfam01895
744872002291	Mg chelatase-related protein; Region: TIGR00368
744872002292	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
744872002293	Walker A motif; other site
744872002294	ATP binding site [chemical binding]; other site
744872002295	Walker B motif; other site
744872002296	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
744872002297	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
744872002298	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
744872002299	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281
744872002300	active site
744872002301	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
744872002302	ligand binding site [chemical binding]; other site
744872002303	flexible hinge region; other site
744872002304	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872002305	binding surface
744872002306	TPR motif; other site
744872002307	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
744872002308	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
744872002309	ligand binding site [chemical binding]; other site
744872002310	flexible hinge region; other site
744872002311	PAS domain S-box; Region: sensory_box; TIGR00229
744872002312	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
744872002313	PAS domain S-box; Region: sensory_box; TIGR00229
744872002314	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
744872002315	putative active site [active]
744872002316	heme pocket [chemical binding]; other site
744872002317	Histidine kinase; Region: HisKA_2; cl06527
744872002318	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872002319	ATP binding site [chemical binding]; other site
744872002320	Mg2+ binding site [ion binding]; other site
744872002321	G-X-G motif; other site
744872002322	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
744872002323	pyruvate kinase; Provisional; Region: PRK06354
744872002324	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
744872002325	domain interfaces; other site
744872002326	active site
744872002327	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
744872002328	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
744872002329	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
744872002330	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
744872002331	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104
744872002332	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
744872002333	active site
744872002334	HIGH motif; other site
744872002335	KMSK motif region; other site
744872002336	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
744872002337	tRNA binding surface [nucleotide binding]; other site
744872002338	anticodon binding site; other site
744872002339	Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382
744872002340	Protein of unknown function (DUF464); Region: DUF464; cl01080
744872002341	Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
744872002342	GTPase CgtA; Reviewed; Region: obgE; PRK12299
744872002343	GTP1/OBG; Region: GTP1_OBG; pfam01018
744872002344	Obg subfamily.  The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation.  Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898
744872002345	G1 box; other site
744872002346	GTP/Mg2+ binding site [chemical binding]; other site
744872002347	Switch I region; other site
744872002348	G2 box; other site
744872002349	G3 box; other site
744872002350	Switch II region; other site
744872002351	G4 box; other site
744872002352	G5 box; other site
744872002353	putative nicotinate-nucleotide adenylyltransferase; Validated; Region: nadD; PRK07152
744872002354	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
744872002355	active site
744872002356	(T/H)XGH motif; other site
744872002357	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
744872002358	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
744872002359	Domain of unknown function DUF143; Region: DUF143; cl00519
744872002360	4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947
744872002361	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
744872002362	SpoVG; Region: SpoVG; cl00915
744872002363	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
744872002364	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
744872002365	5S rRNA interface [nucleotide binding]; other site
744872002366	CTC domain interface [polypeptide binding]; other site
744872002367	L16 interface [polypeptide binding]; other site
744872002368	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
744872002369	Ligand Binding Site [chemical binding]; other site
744872002370	FtsH Extracellular; Region: FtsH_ext; pfam06480
744872002371	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
744872002372	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
744872002373	Walker A motif; other site
744872002374	ATP binding site [chemical binding]; other site
744872002375	Walker B motif; other site
744872002376	arginine finger; other site
744872002377	Peptidase family M41; Region: Peptidase_M41; pfam01434
744872002378	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149
744872002379	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
744872002380	anti sigma factor interaction site; other site
744872002381	regulatory phosphorylation site [posttranslational modification]; other site
744872002382	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
744872002383	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
744872002384	putative binding surface; other site
744872002385	active site
744872002386	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
744872002387	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872002388	ATP binding site [chemical binding]; other site
744872002389	Mg2+ binding site [ion binding]; other site
744872002390	G-X-G motif; other site
744872002391	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
744872002392	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
744872002393	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
744872002394	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
744872002395	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
744872002396	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872002397	active site
744872002398	phosphorylation site [posttranslational modification]
744872002399	intermolecular recognition site; other site
744872002400	dimerization interface [polypeptide binding]; other site
744872002401	CheB methylesterase; Region: CheB_methylest; pfam01339
744872002402	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
744872002403	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872002404	active site
744872002405	phosphorylation site [posttranslational modification]
744872002406	intermolecular recognition site; other site
744872002407	dimerization interface [polypeptide binding]; other site
744872002408	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
744872002409	Response regulator receiver domain; Region: Response_reg; pfam00072
744872002410	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872002411	active site
744872002412	phosphorylation site [posttranslational modification]
744872002413	intermolecular recognition site; other site
744872002414	dimerization interface [polypeptide binding]; other site
744872002415	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
744872002416	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
744872002417	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
744872002418	dimer interface [polypeptide binding]; other site
744872002419	phosphorylation site [posttranslational modification]
744872002420	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872002421	ATP binding site [chemical binding]; other site
744872002422	Mg2+ binding site [ion binding]; other site
744872002423	G-X-G motif; other site
744872002424	Response regulator receiver domain; Region: Response_reg; pfam00072
744872002425	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872002426	active site
744872002427	phosphorylation site [posttranslational modification]
744872002428	intermolecular recognition site; other site
744872002429	dimerization interface [polypeptide binding]; other site
744872002430	Transposase domain (DUF772); Region: DUF772; cl12084
744872002431	GTP-binding protein LepA; Provisional; Region: PRK05433
744872002432	LepA subfamily.  LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome.  LepA is ubiquitous in bacteria and...; Region: LepA; cd01890
744872002433	G1 box; other site
744872002434	putative GEF interaction site [polypeptide binding]; other site
744872002435	GTP/Mg2+ binding site [chemical binding]; other site
744872002436	Switch I region; other site
744872002437	G2 box; other site
744872002438	G3 box; other site
744872002439	Switch II region; other site
744872002440	G4 box; other site
744872002441	G5 box; other site
744872002442	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699
744872002443	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
744872002444	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
744872002445	Thiamine pyrophosphokinase; Region: TPK; cl09135
744872002446	PPIC-type PPIASE domain; Region: Rotamase; cl08278
744872002447	Uncharacterized conserved protein [Function unknown]; Region: COG3391
744872002448	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
744872002449	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
744872002450	active site
744872002451	catalytic tetrad [active]
744872002452	Late embryogenesis abundant protein; Region: LEA_2; cl12118
744872002453	Transcriptional regulators [Transcription]; Region: PurR; COG1609
744872002454	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
744872002455	DNA binding site [nucleotide binding]
744872002456	domain linker motif; other site
744872002457	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
744872002458	RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809
744872002459	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
744872002460	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872002461	Walker A/P-loop; other site
744872002462	ATP binding site [chemical binding]; other site
744872002463	Q-loop/lid; other site
744872002464	ABC transporter signature motif; other site
744872002465	Walker B; other site
744872002466	D-loop; other site
744872002467	H-loop/switch region; other site
744872002468	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215
744872002469	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
744872002470	TM-ABC transporter signature motif; other site
744872002471	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
744872002472	ligand binding site [chemical binding]; other site
744872002473	dimerization interface [polypeptide binding]; other site
744872002474	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of...; Region: ribokinase; cd01174
744872002475	pfkB family carbohydrate kinase; Region: PfkB; pfam00294
744872002476	substrate binding site [chemical binding]; other site
744872002477	dimer interface [polypeptide binding]; other site
744872002478	ATP binding site [chemical binding]; other site
744872002479	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586
744872002480	active site
744872002481	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
744872002482	Predicted permease; Region: DUF318; cl00487
744872002483	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
744872002484	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
744872002485	active site
744872002486	catalytic residues [active]
744872002487	Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768
744872002488	4Fe-4S binding domain; Region: Fer4; cl02805
744872002489	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
744872002490	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
744872002491	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
744872002492	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
744872002493	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872002494	dimer interface [polypeptide binding]; other site
744872002495	conserved gate region; other site
744872002496	putative PBP binding loops; other site
744872002497	ABC-ATPase subunit interface; other site
744872002498	Transcriptional regulators [Transcription]; Region: PurR; COG1609
744872002499	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
744872002500	DNA binding site [nucleotide binding]
744872002501	domain linker motif; other site
744872002502	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
744872002503	dimerization interface [polypeptide binding]; other site
744872002504	ligand binding site [chemical binding]; other site
744872002505	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
744872002506	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
744872002507	beta-phosphoglucomutase; Region: bPGM; TIGR01990
744872002508	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
744872002509	motif II; other site
744872002510	PAS fold; Region: PAS_4; pfam08448
744872002511	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
744872002512	putative active site [active]
744872002513	heme pocket [chemical binding]; other site
744872002514	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
744872002515	Histidine kinase; Region: HisKA_2; cl06527
744872002516	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872002517	ATP binding site [chemical binding]; other site
744872002518	Mg2+ binding site [ion binding]; other site
744872002519	G-X-G motif; other site
744872002520	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
744872002521	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
744872002522	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
744872002523	Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are...; Region: NDPk; cl00335
744872002524	active site
744872002525	multimer interface [polypeptide binding]; other site
744872002526	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
744872002527	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
744872002528	putative ligand binding site [chemical binding]; other site
744872002529	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
744872002530	TM-ABC transporter signature motif; other site
744872002531	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
744872002532	TM-ABC transporter signature motif; other site
744872002533	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
744872002534	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219
744872002535	Walker A/P-loop; other site
744872002536	ATP binding site [chemical binding]; other site
744872002537	Q-loop/lid; other site
744872002538	ABC transporter signature motif; other site
744872002539	Walker B; other site
744872002540	D-loop; other site
744872002541	H-loop/switch region; other site
744872002542	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
744872002543	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
744872002544	Walker A/P-loop; other site
744872002545	ATP binding site [chemical binding]; other site
744872002546	Q-loop/lid; other site
744872002547	ABC transporter signature motif; other site
744872002548	Walker B; other site
744872002549	D-loop; other site
744872002550	H-loop/switch region; other site
744872002551	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
744872002552	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
744872002553	putative catalytic cysteine [active]
744872002554	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
744872002555	nucleotide binding site [chemical binding]; other site
744872002556	homotetrameric interface [polypeptide binding]; other site
744872002557	putative phosphate binding site [ion binding]; other site
744872002558	putative allosteric binding site; other site
744872002559	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872002560	Predicted acetyltransferase [General function prediction only]; Region: COG3393
744872002561	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
744872002562	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
744872002563	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
744872002564	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872002565	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
744872002566	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
744872002567	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
744872002568	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
744872002569	RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394
744872002570	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
744872002571	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
744872002572	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
744872002573	DNA binding residues [nucleotide binding]
744872002574	Divergent polysaccharide deacetylase; Region: Polysacc_deac_2; cl04721
744872002575	UGMP family protein; Validated; Region: PRK09604
744872002576	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
744872002577	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
744872002578	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
744872002579	P-loop; other site
744872002580	elongation factor G; Reviewed; Region: PRK00007
744872002581	Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase).  The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA.  This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886
744872002582	G1 box; other site
744872002583	putative GEF interaction site [polypeptide binding]; other site
744872002584	GTP/Mg2+ binding site [chemical binding]; other site
744872002585	Switch I region; other site
744872002586	G2 box; other site
744872002587	G3 box; other site
744872002588	Switch II region; other site
744872002589	G4 box; other site
744872002590	G5 box; other site
744872002591	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088
744872002592	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cd01680
744872002593	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713
744872002594	ParB-like nuclease domain; Region: ParBc; cl02129
744872002595	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
744872002596	Transglycosylase; Region: Transgly; cl07896
744872002597	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
744872002598	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
744872002599	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
744872002600	putative peptidoglycan binding site; other site
744872002601	Peptidase family M23; Region: Peptidase_M23; pfam01551
744872002602	archaeoflavoprotein, MJ0208 family; Region: flavo_MJ0208; TIGR02700
744872002603	Cache domain; Region: Cache_1; pfam02743
744872002604	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
744872002605	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
744872002606	Sulfatase; Region: Sulfatase; cl10460
744872002607	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
744872002608	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
744872002609	active site
744872002610	phosphorylation site [posttranslational modification]
744872002611	Na+/H+ ion antiporter subunit; Region: MNHE; cl00807
744872002612	Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154
744872002613	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583
744872002614	Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676
744872002615	Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676
744872002616	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
744872002617	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12667
744872002618	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
744872002619	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141
744872002620	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
744872002621	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
744872002622	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
744872002623	M28, and M42; Region: Zinc_peptidase_like; cl14876
744872002624	metal binding site [ion binding]; metal-binding site
744872002625	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
744872002626	active site
744872002627	carbamoyl-phosphate synthase, large subunit; Region: CPSaseII_lrg; TIGR01369
744872002628	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
744872002629	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
744872002630	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
744872002631	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
744872002632	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
744872002633	Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain; Region: MGS_CPS_I_III; cd01423
744872002634	probable substrate binding site [chemical binding]; other site
744872002635	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
744872002636	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056
744872002637	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
744872002638	catalytic site [active]
744872002639	subunit interface [polypeptide binding]; other site
744872002640	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS); Region: YbaK_deacylase; cd00002
744872002641	putative deacylase active site [active]
744872002642	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
744872002643	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
744872002644	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429
744872002645	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
744872002646	GAF domain; Region: GAF; cl00853
744872002647	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
744872002648	metal binding site [ion binding]; metal-binding site
744872002649	active site
744872002650	I-site; other site
744872002651	Response regulator receiver domain; Region: Response_reg; pfam00072
744872002652	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872002653	active site
744872002654	phosphorylation site [posttranslational modification]
744872002655	intermolecular recognition site; other site
744872002656	dimerization interface [polypeptide binding]; other site
744872002657	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
744872002658	metal ion-dependent adhesion site (MIDAS); other site
744872002659	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
744872002660	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group...; Region: OAT; cd02152
744872002661	heterotetramer interface [polypeptide binding]; other site
744872002662	active site pocket [active]
744872002663	cleavage site
744872002664	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using...; Region: AAK_NAGK-C; cd04250
744872002665	feedback inhibition sensing region; other site
744872002666	homohexameric interface [polypeptide binding]; other site
744872002667	nucleotide binding site [chemical binding]; other site
744872002668	N-acetyl-L-glutamate binding site [chemical binding]; other site
744872002669	acetylornithine aminotransferase; Provisional; Region: PRK02627
744872002670	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610
744872002671	inhibitor-cofactor binding pocket; inhibition site
744872002672	pyridoxal 5'-phosphate binding site [chemical binding]; other site
744872002673	catalytic residue [active]
744872002674	argininosuccinate synthase; Provisional; Region: PLN00200
744872002675	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
744872002676	ANP binding site [chemical binding]; other site
744872002677	Substrate Binding Site II [chemical binding]; other site
744872002678	Substrate Binding Site I [chemical binding]; other site
744872002679	argininosuccinate lyase; Provisional; Region: PRK00855
744872002680	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
744872002681	active sites [active]
744872002682	tetramer interface [polypeptide binding]; other site
744872002683	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
744872002684	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
744872002685	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
744872002686	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614
744872002687	NAD(P) binding site [chemical binding]; other site
744872002688	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
744872002689	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
744872002690	active site
744872002691	HIGH motif; other site
744872002692	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
744872002693	active site
744872002694	KMSKS motif; other site
744872002695	Arginase family; Region: Arginase; cl00306
744872002696	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424
744872002697	dimer interface [polypeptide binding]; other site
744872002698	ADP-ribose binding site [chemical binding]; other site
744872002699	active site
744872002700	nudix motif; other site
744872002701	metal binding site [ion binding]; metal-binding site
744872002702	glycyl-tRNA synthetase; Provisional; Region: PRK04173
744872002703	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the...; Region: GlyRS-like_core; cd00774
744872002704	dimer interface [polypeptide binding]; other site
744872002705	motif 1; other site
744872002706	active site
744872002707	motif 2; other site
744872002708	motif 3; other site
744872002709	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
744872002710	anticodon binding site; other site
744872002711	argininosuccinate lyase; Provisional; Region: PRK02186
744872002712	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
744872002713	Predicted permease; Region: DUF318; cl00487
744872002714	Predicted permease; Region: DUF318; cl00487
744872002715	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
744872002716	active site
744872002717	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
744872002718	active site
744872002719	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
744872002720	non-specific DNA binding site [nucleotide binding]; other site
744872002721	salt bridge; other site
744872002722	sequence-specific DNA binding site [nucleotide binding]; other site
744872002723	4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279
744872002724	Putative transposase; Region: Y2_Tnp; pfam04986
744872002725	Omptin family; Region: Omptin; cl01886
744872002726	Esterase/lipase [General function prediction only]; Region: COG1647
744872002727	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
744872002728	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
744872002729	Walker A motif; other site
744872002730	ATP binding site [chemical binding]; other site
744872002731	Walker B motif; other site
744872002732	arginine finger; other site
744872002733	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
744872002734	intersubunit interface [polypeptide binding]; other site
744872002735	active site
744872002736	catalytic residue [active]
744872002737	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
744872002738	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
744872002739	ligand binding site [chemical binding]; other site
744872002740	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
744872002741	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216
744872002742	Walker A/P-loop; other site
744872002743	ATP binding site [chemical binding]; other site
744872002744	Q-loop/lid; other site
744872002745	ABC transporter signature motif; other site
744872002746	Walker B; other site
744872002747	D-loop; other site
744872002748	H-loop/switch region; other site
744872002749	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215
744872002750	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580
744872002751	TM-ABC transporter signature motif; other site
744872002752	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580
744872002753	TM-ABC transporter signature motif; other site
744872002754	alanyl-tRNA synthetase; Provisional; Region: PRK01584
744872002755	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673
744872002756	motif 1; other site
744872002757	active site
744872002758	motif 2; other site
744872002759	motif 3; other site
744872002760	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
744872002761	SurA N-terminal domain; Region: SurA_N; pfam09312
744872002762	PPIC-type PPIASE domain; Region: Rotamase; cl08278
744872002763	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
744872002764	putative RNA binding site [nucleotide binding]; other site
744872002765	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429
744872002766	TPR motif; other site
744872002767	binding surface
744872002768	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872002769	binding surface
744872002770	TPR motif; other site
744872002771	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320
744872002772	oligomerisation interface [polypeptide binding]; other site
744872002773	mobile loop; other site
744872002774	roof hairpin; other site
744872002775	SEC-C motif; Region: SEC-C; cl12132
744872002776	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
744872002777	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
744872002778	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
744872002779	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
744872002780	DNA binding residues [nucleotide binding]
744872002781	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
744872002782	dimer interface [polypeptide binding]; other site
744872002783	active site
744872002784	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
744872002785	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
744872002786	DNA-binding site [nucleotide binding]; DNA binding site
744872002787	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
744872002788	pyridoxal 5'-phosphate binding site [chemical binding]; other site
744872002789	homodimer interface [polypeptide binding]; other site
744872002790	catalytic residue [active]
744872002791	pyridoxal biosynthesis lyase PdxS; Provisional; Region: PRK04180
744872002792	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
744872002793	active site
744872002794	multimer interface [polypeptide binding]; other site
744872002795	Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118
744872002796	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
744872002797	predicted active site [active]
744872002798	catalytic triad [active]
744872002799	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
744872002800	glutamate dehydrogenase; Provisional; Region: PRK09414
744872002801	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
744872002802	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
744872002803	NAD(P) binding site [chemical binding]; other site
744872002804	Repressor of nif and glnA expression [Transcription]; Region: COG1693
744872002805	Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461
744872002806	Domain of unknown function DUF128; Region: DUF128; pfam01995
744872002807	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
744872002808	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
744872002809	catalytic residues [active]
744872002810	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
744872002811	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
744872002812	non-specific DNA binding site [nucleotide binding]; other site
744872002813	salt bridge; other site
744872002814	sequence-specific DNA binding site [nucleotide binding]; other site
744872002815	Cupin domain; Region: Cupin_2; cl09118
744872002816	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
744872002817	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
744872002818	substrate binding site [chemical binding]; other site
744872002819	ligand binding site [chemical binding]; other site
744872002820	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577
744872002821	substrate binding site [chemical binding]; other site
744872002822	MFS_1 like family; Region: MFS_1_like; pfam12832
744872002823	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
744872002824	Protein of unknown function (DUF554); Region: DUF554; cl00784
744872002825	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
744872002826	The N-terminal ATPase domain of the maltose transporter, MalK.  ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles.  ABC transporters contain two...; Region: ABC_MalK_N; cd03301
744872002827	Walker A/P-loop; other site
744872002828	ATP binding site [chemical binding]; other site
744872002829	Q-loop/lid; other site
744872002830	ABC transporter signature motif; other site
744872002831	Walker B; other site
744872002832	D-loop; other site
744872002833	H-loop/switch region; other site
744872002834	TOBE domain; Region: TOBE_2; cl01440
744872002835	CheD chemotactic sensory transduction; Region: CheD; cl00810
744872002836	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
744872002837	RNB domain; Region: RNB; pfam00773
744872002838	aspartate kinase; Provisional; Region: PRK06291
744872002839	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
744872002840	nucleotide binding site [chemical binding]; other site
744872002841	substrate binding site [chemical binding]; other site
744872002842	ACT domains located C-terminal to the catalytic domain of  the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912
744872002843	dimer interface [polypeptide binding]; other site
744872002844	allosteric regulatory binding pocket; other site
744872002845	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141
744872002846	dihydrodipicolinate reductase; Provisional; Region: PRK00048
744872002847	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872002848	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
744872002849	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
744872002850	dihydrodipicolinate synthase; Region: dapA; TIGR00674
744872002851	dimer interface [polypeptide binding]; other site
744872002852	active site
744872002853	catalytic residue [active]
744872002854	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664
744872002855	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872002856	Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774
744872002857	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
744872002858	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
744872002859	active site
744872002860	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
744872002861	substrate binding site [chemical binding]; other site
744872002862	catalytic residues [active]
744872002863	dimer interface [polypeptide binding]; other site
744872002864	aspartate aminotransferase; Provisional; Region: PRK07681
744872002865	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
744872002866	pyridoxal 5'-phosphate binding site [chemical binding]; other site
744872002867	homodimer interface [polypeptide binding]; other site
744872002868	catalytic residue [active]
744872002869	Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases, one  highly specific for asparagine and localised to the...; Region: Asparaginase; cl00216
744872002870	active site/substrate binding site [active]
744872002871	putative transposase OrfB; Reviewed; Region: PHA02517
744872002872	Transposase; Region: HTH_Tnp_Tc3_2; pfam01498
744872002873	Integrase core domain; Region: rve; cl01316
744872002874	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
744872002875	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
744872002876	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
744872002877	putative binding surface; other site
744872002878	active site
744872002879	P2 response regulator binding domain; Region: P2; pfam07194
744872002880	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
744872002881	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872002882	ATP binding site [chemical binding]; other site
744872002883	Mg2+ binding site [ion binding]; other site
744872002884	G-X-G motif; other site
744872002885	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
744872002886	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
744872002887	putative CheA interaction surface; other site
744872002888	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
744872002889	Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406
744872002890	CheC-like family; Region: CheC; pfam04509
744872002891	Response regulator receiver domain; Region: Response_reg; pfam00072
744872002892	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872002893	active site
744872002894	phosphorylation site [posttranslational modification]
744872002895	intermolecular recognition site; other site
744872002896	dimerization interface [polypeptide binding]; other site
744872002897	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
744872002898	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
744872002899	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
744872002900	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
744872002901	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872002902	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
744872002903	elongation factor P; Validated; Region: PRK00529
744872002904	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
744872002905	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470
744872002906	RNA binding site [nucleotide binding]; other site
744872002907	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794
744872002908	RNA binding site [nucleotide binding]; other site
744872002909	sensory histidine kinase AtoS; Provisional; Region: PRK11360
744872002910	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
744872002911	dimer interface [polypeptide binding]; other site
744872002912	phosphorylation site [posttranslational modification]
744872002913	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872002914	ATP binding site [chemical binding]; other site
744872002915	Mg2+ binding site [ion binding]; other site
744872002916	G-X-G motif; other site
744872002917	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
744872002918	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872002919	active site
744872002920	phosphorylation site [posttranslational modification]
744872002921	intermolecular recognition site; other site
744872002922	dimerization interface [polypeptide binding]; other site
744872002923	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
744872002924	Walker A motif; other site
744872002925	ATP binding site [chemical binding]; other site
744872002926	Walker B motif; other site
744872002927	arginine finger; other site
744872002928	Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
744872002929	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-...; Region: SirA_YedF_YeeD; cd00291
744872002930	CPxP  motif; other site
744872002931	putative inner membrane protein; Provisional; Region: PRK11099
744872002932	YeeE/YedE family (DUF395); Region: DUF395; cl01018
744872002933	putative inner membrane protein; Provisional; Region: PRK11099
744872002934	YeeE/YedE family (DUF395); Region: DUF395; cl01018
744872002935	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
744872002936	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872002937	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872002938	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
744872002939	Late embryogenesis abundant protein; Region: LEA_2; cl12118
744872002940	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232
744872002941	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046
744872002942	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
744872002943	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
744872002944	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
744872002945	Truncated, possibly inactive, lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: COG2269
744872002946	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
744872002947	motif 1; other site
744872002948	dimer interface [polypeptide binding]; other site
744872002949	active site
744872002950	motif 2; other site
744872002951	motif 3; other site
744872002952	UDP-N-acetylmuramoylalanine--D-glutamate ligase; Region: murD; TIGR01087
744872002953	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
744872002954	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951
744872002955	Protein of unknown function (DUF2804); Region: DUF2804; pfam10974
744872002956	Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253
744872002957	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
744872002958	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
744872002959	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
744872002960	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
744872002961	UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085
744872002962	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
744872002963	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
744872002964	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
744872002965	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
744872002966	active site
744872002967	AMMECR1; Region: AMMECR1; cl00911
744872002968	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
744872002969	amidase; Provisional; Region: PRK07139
744872002970	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
744872002971	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
744872002972	GatB domain; Region: GatB_Yqey; cl11497
744872002973	aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159
744872002974	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
744872002975	Dimer interface [polypeptide binding]; other site
744872002976	anticodon binding site; other site
744872002977	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
744872002978	motif 1; other site
744872002979	dimer interface [polypeptide binding]; other site
744872002980	active site
744872002981	motif 2; other site
744872002982	motif 3; other site
744872002983	Cupin domain; Region: Cupin_2; cl09118
744872002984	Hexokinase [Carbohydrate transport and metabolism]; Region: COG5026
744872002985	Hexokinase; Region: Hexokinase_1; pfam00349
744872002986	Hexokinase; Region: Hexokinase_2; pfam03727
744872002987	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl11605
744872002988	hemerythrin-like metal-binding domain; Region: hemeryth_dom; TIGR02481
744872002989	octamerization interface [polypeptide binding]; other site
744872002990	diferric-oxygen binding site [ion binding]; other site
744872002991	Uncharacterized conserved protein [Function unknown]; Region: COG2461
744872002992	Family of unknown function (DUF438); Region: DUF438; pfam04282
744872002993	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl11605
744872002994	4Fe-4S binding domain; Region: Fer4; cl02805
744872002995	MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149
744872002996	Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061
744872002997	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
744872002998	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872002999	TPR motif; other site
744872003000	binding surface
744872003001	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
744872003002	putative ligand binding pocket/active site [active]
744872003003	putative metal binding site [ion binding]; other site
744872003004	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
744872003005	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225
744872003006	dimerization interface [polypeptide binding]; other site
744872003007	cyclase homology domain; Region: CHD; cd07302
744872003008	nucleotidyl binding site; other site
744872003009	metal binding site [ion binding]; metal-binding site
744872003010	dimer interface [polypeptide binding]; other site
744872003011	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
744872003012	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
744872003013	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
744872003014	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
744872003015	Domain of unknown function (DUF814); Region: DUF814; pfam05670
744872003016	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
744872003017	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
744872003018	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
744872003019	N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_N_terminal_like; cd03312
744872003020	THF binding site; other site
744872003021	C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311
744872003022	substrate binding site [chemical binding]; other site
744872003023	THF binding site; other site
744872003024	zinc-binding site [ion binding]; other site
744872003025	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
744872003026	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869
744872003027	active site
744872003028	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
744872003029	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
744872003030	Peptidase family U32; Region: Peptidase_U32; cl03113
744872003031	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141
744872003032	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869
744872003033	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
744872003034	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
744872003035	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
744872003036	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
744872003037	catalytic motif [active]
744872003038	Zn binding site [ion binding]; other site
744872003039	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
744872003040	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192
744872003041	substrate binding site [chemical binding]; other site
744872003042	ATP binding site [chemical binding]; other site
744872003043	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
744872003044	MatE; Region: MatE; cl10513
744872003045	MatE; Region: MatE; cl10513
744872003046	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
744872003047	Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890
744872003048	putative active site [active]
744872003049	putative metal binding residues [ion binding]; other site
744872003050	signature motif; other site
744872003051	putative triphosphate binding site [ion binding]; other site
744872003052	dimer interface [polypeptide binding]; other site
744872003053	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
744872003054	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
744872003055	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
744872003056	putative peptidoglycan binding site; other site
744872003057	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
744872003058	putative peptidoglycan binding site; other site
744872003059	Peptidase family M23; Region: Peptidase_M23; pfam01551
744872003060	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
744872003061	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
744872003062	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
744872003063	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
744872003064	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
744872003065	DNA binding residues [nucleotide binding]
744872003066	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
744872003067	active site
744872003068	substrate binding site [chemical binding]; other site
744872003069	catalytic site [active]
744872003070	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
744872003071	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-...; Region: PGM2; cd05799
744872003072	active site
744872003073	substrate binding site [chemical binding]; other site
744872003074	metal binding site [ion binding]; metal-binding site
744872003075	Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; cl01458
744872003076	pyruvate carboxylase subunit B; Validated; Region: PRK09282
744872003077	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
744872003078	active site
744872003079	catalytic residues [active]
744872003080	metal binding site [ion binding]; metal-binding site
744872003081	homodimer binding site [polypeptide binding]; other site
744872003082	Conserved carboxylase domain; Region: PYC_OADA; pfam02436
744872003083	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850
744872003084	carboxyltransferase (CT) interaction site; other site
744872003085	biotinylation site [posttranslational modification]; other site
744872003086	subunit; Region: OAD_beta; cl00816
744872003087	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
744872003088	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
744872003089	RNA/DNA hybrid binding site [nucleotide binding]; other site
744872003090	active site
744872003091	Protein of unknown function (DUF3276); Region: DUF3276; cl15305
744872003092	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2)...; Region: phosphohexomutase; cl03757
744872003093	active site
744872003094	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
744872003095	substrate binding site [chemical binding]; other site
744872003096	metal binding site [ion binding]; metal-binding site
744872003097	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
744872003098	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998
744872003099	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
744872003100	S-adenosylmethionine binding site [chemical binding]; other site
744872003101	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
744872003102	Peptidase family M23; Region: Peptidase_M23; pfam01551
744872003103	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
744872003104	active site
744872003105	catalytic motif [active]
744872003106	Zn binding site [ion binding]; other site
744872003107	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
744872003108	DNA binding residues [nucleotide binding]
744872003109	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
744872003110	active site
744872003111	phosphorylation site [posttranslational modification]
744872003112	Thymidine kinase; Region: TK; cl00631
744872003113	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869
744872003114	active site
744872003115	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
744872003116	Uncharacterized conserved protein [Function unknown]; Region: COG1543
744872003117	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
744872003118	Uncharacterised protein family (UPF0164); Region: UPF0164; pfam03687
744872003119	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
744872003120	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
744872003121	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
744872003122	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
744872003123	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
744872003124	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
744872003125	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
744872003126	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872003127	dimer interface [polypeptide binding]; other site
744872003128	conserved gate region; other site
744872003129	putative PBP binding loops; other site
744872003130	ABC-ATPase subunit interface; other site
744872003131	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
744872003132	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872003133	TPR motif; other site
744872003134	binding surface
744872003135	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
744872003136	Outer membrane efflux protein; Region: OEP; pfam02321
744872003137	Outer membrane efflux protein; Region: OEP; pfam02321
744872003138	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
744872003139	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
744872003140	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
744872003141	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
744872003142	Peptidase family M23; Region: Peptidase_M23; pfam01551
744872003143	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
744872003144	Transposase, Mutator family; Region: Transposase_mut; pfam00872
744872003145	MULE transposase domain; Region: MULE; pfam10551
744872003146	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
744872003147	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
744872003148	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
744872003149	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
744872003150	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
744872003151	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
744872003152	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
744872003153	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
744872003154	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
744872003155	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
744872003156	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
744872003157	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
744872003158	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
744872003159	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
744872003160	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
744872003161	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This...; Region: Alpha_ANH_like_II; cd01993
744872003162	Ligand Binding Site [chemical binding]; other site
744872003163	Late competence development protein ComFB; Region: ComFB; pfam10719
744872003164	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
744872003165	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
744872003166	Zn2+ binding site [ion binding]; other site
744872003167	Mg2+ binding site [ion binding]; other site
744872003168	aconitate hydratase; Validated; Region: PRK07229
744872003169	Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585
744872003170	substrate binding site [chemical binding]; other site
744872003171	ligand binding site [chemical binding]; other site
744872003172	Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle.  Cis-aconitate is formed as an intermediate product during the...; Region: AcnA_Bact_Swivel; cd01579
744872003173	substrate binding site [chemical binding]; other site
744872003174	PilZ domain; Region: PilZ; cl01260
744872003175	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
744872003176	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
744872003177	anti sigma factor interaction site; other site
744872003178	regulatory phosphorylation site [posttranslational modification]; other site
744872003179	GAF domain; Region: GAF; cl00853
744872003180	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
744872003181	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
744872003182	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
744872003183	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
744872003184	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872003185	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
744872003186	ABC transporter; Region: ABC_tran_2; pfam12848
744872003187	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
744872003188	Haemolysin-III related; Region: HlyIII; cl03831
744872003189	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
744872003190	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
744872003191	DHH family; Region: DHH; pfam01368
744872003192	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
744872003193	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate...; Region: APP_MetAP; cl00279
744872003194	active site
744872003195	ornithine carbamoyltransferase; Validated; Region: PRK02102
744872003196	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
744872003197	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872003198	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872003199	TPR motif; other site
744872003200	binding surface
744872003201	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
744872003202	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
744872003203	FeS/SAM binding site; other site
744872003204	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270
744872003205	ATP cone domain; Region: ATP-cone; pfam03477
744872003206	Class III ribonucleotide reductase; Region: RNR_III; cd01675
744872003207	effector binding site; other site
744872003208	active site
744872003209	Zn binding site [ion binding]; other site
744872003210	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
744872003211	ATP cone domain; Region: ATP-cone; pfam03477
744872003212	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
744872003213	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
744872003214	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
744872003215	Found in ATP-dependent protease La (LON); Region: LON; smart00464
744872003216	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
744872003217	Walker A motif; other site
744872003218	ATP binding site [chemical binding]; other site
744872003219	Walker B motif; other site
744872003220	arginine finger; other site
744872003221	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
744872003222	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
744872003223	ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964
744872003224	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872003225	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
744872003226	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
744872003227	oligomer interface [polypeptide binding]; other site
744872003228	active site residues [active]
744872003229	trigger factor; Region: tig; TIGR00115
744872003230	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
744872003231	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
744872003232	FlgN protein; Region: FlgN; cl09176
744872003233	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06665
744872003234	Flagellin hook IN motif; Region: Flagellin_IN; pfam07196
744872003235	Domain of unknown function (DUF1078); Region: DUF1078; pfam06429
744872003236	flagellar hook-associated protein FlgL; Validated; Region: PRK06663
744872003237	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
744872003238	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
744872003239	FliW protein; Region: FliW; cl00740
744872003240	Global regulator protein family; Region: CsrA; cl00670
744872003241	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
744872003242	Zn2+ binding site [ion binding]; other site
744872003243	Mg2+ binding site [ion binding]; other site
744872003244	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
744872003245	Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520
744872003246	PilZ domain; Region: PilZ; cl01260
744872003247	flagellar hook-associated protein FliD; Validated; Region: fliD; PRK06664
744872003248	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
744872003249	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
744872003250	FlaG protein; Region: FlaG; cl00591
744872003251	flagellin; Provisional; Region: PRK12804
744872003252	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
744872003253	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
744872003254	flagellin; Provisional; Region: PRK12804
744872003255	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
744872003256	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
744872003257	recombination factor protein RarA/unknown domain fusion protein; Reviewed; Region: PRK13341
744872003258	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
744872003259	Walker A motif; other site
744872003260	ATP binding site [chemical binding]; other site
744872003261	Walker B motif; other site
744872003262	arginine finger; other site
744872003263	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
744872003264	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190
744872003265	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
744872003266	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
744872003267	homodimer interface [polypeptide binding]; other site
744872003268	NADP binding site [chemical binding]; other site
744872003269	substrate binding site [chemical binding]; other site
744872003270	Uncharacterized ACR, COG1469; Region: DUF198; cl00642
744872003271	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14335
744872003272	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
744872003273	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
744872003274	FeS/SAM binding site; other site
744872003275	TRAM domain; Region: TRAM; cl01282
744872003276	Sporulation related domain; Region: SPOR; cl10051
744872003277	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
744872003278	DHH family; Region: DHH; pfam01368
744872003279	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
744872003280	metal ion-dependent adhesion site (MIDAS); other site
744872003281	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
744872003282	pyruvate phosphate dikinase; Provisional; Region: PRK09279
744872003283	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
744872003284	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
744872003285	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
744872003286	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
744872003287	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872003288	binding surface
744872003289	TPR motif; other site
744872003290	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872003291	binding surface
744872003292	TPR motif; other site
744872003293	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
744872003294	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
744872003295	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872003296	Polymer-forming cytoskeletal; Region: Bactofilin; cl09137
744872003297	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872003298	TPR motif; other site
744872003299	binding surface
744872003300	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872003301	TPR motif; other site
744872003302	binding surface
744872003303	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
744872003304	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
744872003305	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
744872003306	FeS/SAM binding site; other site
744872003307	Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908
744872003308	putative ADP-ribose binding site [chemical binding]; other site
744872003309	putative active site [active]
744872003310	Uncharacterised ACR, YggU family COG1872; Region: DUF167; cl00811
744872003311	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
744872003312	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
744872003313	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
744872003314	YjeQ/EngC.  YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854
744872003315	GTPase RsgA; Reviewed; Region: PRK00098
744872003316	GTPase/OB domain interface [polypeptide binding]; other site
744872003317	GTPase/Zn-binding domain interface [polypeptide binding]; other site
744872003318	GTP/Mg2+ binding site [chemical binding]; other site
744872003319	G4 box; other site
744872003320	G5 box; other site
744872003321	G1 box; other site
744872003322	Switch I region; other site
744872003323	G2 box; other site
744872003324	G3 box; other site
744872003325	Switch II region; other site
744872003326	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
744872003327	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872003328	Walker A/P-loop; other site
744872003329	ATP binding site [chemical binding]; other site
744872003330	Q-loop/lid; other site
744872003331	ABC transporter signature motif; other site
744872003332	Walker B; other site
744872003333	D-loop; other site
744872003334	H-loop/switch region; other site
744872003335	Smr domain; Region: Smr; cl02619
744872003336	TM2 domain; Region: TM2; cl00984
744872003337	Protein of unknown function (DUF342); Region: DUF342; pfam03961
744872003338	Arginine repressor [Transcription]; Region: ArgR; COG1438
744872003339	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
744872003340	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
744872003341	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095
744872003342	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
744872003343	active site
744872003344	dimer interface [polypeptide binding]; other site
744872003345	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
744872003346	dimer interface [polypeptide binding]; other site
744872003347	active site
744872003348	Cache domain; Region: Cache_1; pfam02743
744872003349	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225
744872003350	dimerization interface [polypeptide binding]; other site
744872003351	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
744872003352	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
744872003353	M28, and M42; Region: Zinc_peptidase_like; cl14876
744872003354	metal binding site [ion binding]; metal-binding site
744872003355	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
744872003356	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
744872003357	dimerization interface [polypeptide binding]; other site
744872003358	domain crossover interface; other site
744872003359	redox-dependent activation switch; other site
744872003360	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
744872003361	Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403
744872003362	putative active site [active]
744872003363	putative metal binding site [ion binding]; other site
744872003364	Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403
744872003365	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
744872003366	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872003367	binding surface
744872003368	TPR motif; other site
744872003369	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872003370	binding surface
744872003371	TPR motif; other site
744872003372	Restriction endonuclease; Region: Mrr_cat; cl00747
744872003373	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429
744872003374	TPR motif; other site
744872003375	binding surface
744872003376	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872003377	binding surface
744872003378	TPR motif; other site
744872003379	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
744872003380	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872003381	binding surface
744872003382	TPR motif; other site
744872003383	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872003384	binding surface
744872003385	TPR motif; other site
744872003386	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872003387	binding surface
744872003388	TPR motif; other site
744872003389	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872003390	binding surface
744872003391	TPR motif; other site
744872003392	Domain of unknown function DUF20; Region: UPF0118; cl00465
744872003393	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
744872003394	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
744872003395	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
744872003396	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
744872003397	minor groove reading motif; other site
744872003398	helix-hairpin-helix signature motif; other site
744872003399	substrate binding pocket [chemical binding]; other site
744872003400	active site
744872003401	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
744872003402	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
744872003403	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
744872003404	HIGH motif; other site
744872003405	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
744872003406	active site
744872003407	KMSKS motif; other site
744872003408	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
744872003409	tRNA binding surface [nucleotide binding]; other site
744872003410	anticodon binding site; other site
744872003411	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
744872003412	Double zinc ribbon; Region: DZR; pfam12773
744872003413	Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180
744872003414	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
744872003415	FeS/SAM binding site; other site
744872003416	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
744872003417	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
744872003418	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
744872003419	putative NADH binding site [chemical binding]; other site
744872003420	putative active site [active]
744872003421	nudix motif; other site
744872003422	putative metal binding site [ion binding]; other site
744872003423	fumarate hydratase; Provisional; Region: PRK15389
744872003424	Fumarate hydratase (Fumerase); Region: Fumerase; cl00851
744872003425	Fumarase C-terminus; Region: Fumerase_C; cl00795
744872003426	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872003427	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872003428	Walker A/P-loop; other site
744872003429	ATP binding site [chemical binding]; other site
744872003430	Q-loop/lid; other site
744872003431	ABC transporter signature motif; other site
744872003432	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
744872003433	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
744872003434	dimer interface [polypeptide binding]; other site
744872003435	phosphorylation site [posttranslational modification]
744872003436	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872003437	ATP binding site [chemical binding]; other site
744872003438	Mg2+ binding site [ion binding]; other site
744872003439	G-X-G motif; other site
744872003440	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
744872003441	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872003442	active site
744872003443	phosphorylation site [posttranslational modification]
744872003444	intermolecular recognition site; other site
744872003445	dimerization interface [polypeptide binding]; other site
744872003446	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
744872003447	Walker A motif; other site
744872003448	ATP binding site [chemical binding]; other site
744872003449	Walker B motif; other site
744872003450	arginine finger; other site
744872003451	Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
744872003452	FtsH protease regulator HflC; Provisional; Region: PRK11029
744872003453	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
744872003454	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
744872003455	HflK protein; Region: hflK; TIGR01933
744872003456	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
744872003457	IPP transferase; Region: IPPT; cl00403
744872003458	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
744872003459	TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007
744872003460	TPP-binding site; other site
744872003461	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
744872003462	PYR/PP interface [polypeptide binding]; other site
744872003463	dimer interface [polypeptide binding]; other site
744872003464	TPP binding site [chemical binding]; other site
744872003465	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
744872003466	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
744872003467	dihydropteroate synthase; Region: DHPS; TIGR01496
744872003468	substrate binding pocket [chemical binding]; other site
744872003469	dimer interface [polypeptide binding]; other site
744872003470	inhibitor binding site; inhibition site
744872003471	Uncharacterized conserved protein [Function unknown]; Region: COG1624
744872003472	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
744872003473	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
744872003474	YbbR-like protein; Region: YbbR; pfam07949
744872003475	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
744872003476	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655
744872003477	Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986
744872003478	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
744872003479	PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570
744872003480	dimerization interface 3.5A [polypeptide binding]; other site
744872003481	active site
744872003482	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal...; Region: BtuF; cd01144
744872003483	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
744872003484	cobalamin binding residues [chemical binding]; other site
744872003485	putative BtuC binding residues; other site
744872003486	dimer interface [polypeptide binding]; other site
744872003487	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
744872003488	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462
744872003489	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550
744872003490	ABC-ATPase subunit  interface; other site
744872003491	dimer interface [polypeptide binding]; other site
744872003492	putative PBP binding regions; other site
744872003493	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
744872003494	ABC component of the metal-type transporters.  This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc.  The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235
744872003495	branched-chain amino acid aminotransferase; Provisional; Region: PRK12479
744872003496	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and D-...; Region: D-AAT_like; cd01558
744872003497	homodimer interface [polypeptide binding]; other site
744872003498	substrate-cofactor binding pocket; other site
744872003499	pyridoxal 5'-phosphate binding site [chemical binding]; other site
744872003500	catalytic residue [active]
744872003501	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
744872003502	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT), serine-...; Region: AGAT_like; cd06451
744872003503	homodimer interface [polypeptide binding]; other site
744872003504	pyridoxal 5'-phosphate binding site [chemical binding]; other site
744872003505	catalytic residue [active]
744872003506	Protein of unknown function (DUF1212); Region: DUF1212; cl01118
744872003507	Protein of unknown function (DUF1212); Region: DUF1212; cl01118
744872003508	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
744872003509	Domain of unknown function DUF21; Region: DUF21; pfam01595
744872003510	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
744872003511	Transporter associated domain; Region: CorC_HlyC; cl08393
744872003512	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
744872003513	Zn2+ binding site [ion binding]; other site
744872003514	Mg2+ binding site [ion binding]; other site
744872003515	tyrosine aminotransferase, eukaryotic; Region: tyr_amTase_E; TIGR01264
744872003516	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
744872003517	pyridoxal 5'-phosphate binding site [chemical binding]; other site
744872003518	homodimer interface [polypeptide binding]; other site
744872003519	catalytic residue [active]
744872003520	Thiamine pyrophosphokinase; Region: TPK; cl09135
744872003521	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
744872003522	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
744872003523	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
744872003524	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
744872003525	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
744872003526	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
744872003527	Catalytic site [active]
744872003528	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
744872003529	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
744872003530	putative peptidoglycan binding site; other site
744872003531	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
744872003532	putative peptidoglycan binding site; other site
744872003533	Peptidase family M23; Region: Peptidase_M23; pfam01551
744872003534	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
744872003535	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
744872003536	putative active site [active]
744872003537	PhoH-like protein; Region: PhoH; cl12134
744872003538	Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061
744872003539	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
744872003540	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
744872003541	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
744872003542	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
744872003543	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
744872003544	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
744872003545	PhoH-like protein; Region: PhoH; cl12134
744872003546	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
744872003547	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
744872003548	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
744872003549	Zn2+ binding site [ion binding]; other site
744872003550	Mg2+ binding site [ion binding]; other site
744872003551	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
744872003552	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
744872003553	Transporter associated domain; Region: CorC_HlyC; cl08393
744872003554	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872003555	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
744872003556	binding surface
744872003557	TPR motif; other site
744872003558	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872003559	binding surface
744872003560	TPR motif; other site
744872003561	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
744872003562	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442
744872003563	peptide chain release factor 2; Validated; Region: prfB; PRK00578
744872003564	RF-1 domain; Region: RF-1; cl02875
744872003565	RF-1 domain; Region: RF-1; cl02875
744872003566	PEGA domain; Region: PEGA; pfam08308
744872003567	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
744872003568	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
744872003569	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
744872003570	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
744872003571	FtsX-like permease family; Region: FtsX; pfam02687
744872003572	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
744872003573	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
744872003574	Walker A/P-loop; other site
744872003575	ATP binding site [chemical binding]; other site
744872003576	Q-loop/lid; other site
744872003577	ABC transporter signature motif; other site
744872003578	Walker B; other site
744872003579	D-loop; other site
744872003580	H-loop/switch region; other site
744872003581	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
744872003582	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
744872003583	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
744872003584	UvrB/uvrC motif; Region: UVR; pfam02151
744872003585	Arginine kinase [Amino acid transport and metabolism]; Region: COG3869
744872003586	Phosphagen (guanidino) kinases; Region: phosphagen_kinases; cl02823
744872003587	ADP binding site [chemical binding]; other site
744872003588	phosphagen binding site; other site
744872003589	substrate specificity loop; other site
744872003590	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
744872003591	Clp amino terminal domain; Region: Clp_N; pfam02861
744872003592	Clp amino terminal domain; Region: Clp_N; pfam02861
744872003593	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
744872003594	Walker A motif; other site
744872003595	ATP binding site [chemical binding]; other site
744872003596	Walker B motif; other site
744872003597	arginine finger; other site
744872003598	UvrB/uvrC motif; Region: UVR; pfam02151
744872003599	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
744872003600	Walker A motif; other site
744872003601	ATP binding site [chemical binding]; other site
744872003602	Walker B motif; other site
744872003603	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
744872003604	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
744872003605	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
744872003606	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
744872003607	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
744872003608	catalytic residue [active]
744872003609	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340
744872003610	catalytic residues [active]
744872003611	dimer interface [polypeptide binding]; other site
744872003612	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
744872003613	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862
744872003614	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
744872003615	ligand binding site [chemical binding]; other site
744872003616	oligomer interface [polypeptide binding]; other site
744872003617	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651
744872003618	dimer interface [polypeptide binding]; other site
744872003619	N-terminal domain interface [polypeptide binding]; other site
744872003620	sulfate 1 binding site; other site
744872003621	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
744872003622	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
744872003623	ATP binding site [chemical binding]; other site
744872003624	putative Mg++ binding site [ion binding]; other site
744872003625	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
744872003626	nucleotide binding region [chemical binding]; other site
744872003627	ATP-binding site [chemical binding]; other site
744872003628	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
744872003629	Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359
744872003630	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
744872003631	active site
744872003632	catalytic site [active]
744872003633	substrate binding site [chemical binding]; other site
744872003634	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
744872003635	UvrD/REP helicase; Region: UvrD-helicase; cl14126
744872003636	UvrD/REP helicase; Region: UvrD-helicase; cl14126
744872003637	Putative small multi-drug export protein; Region: Sm_multidrug_ex; cl01024
744872003638	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to...; Region: YbiR_permease; cd01117
744872003639	transmembrane helices; other site
744872003640	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515
744872003641	active site
744872003642	dimerization interface [polypeptide binding]; other site
744872003643	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
744872003644	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259
744872003645	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872003646	DEAD-like helicases superfamily; Region: DEXDc; smart00487
744872003647	ATP binding site [chemical binding]; other site
744872003648	putative Mg++ binding site [ion binding]; other site
744872003649	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
744872003650	nucleotide binding region [chemical binding]; other site
744872003651	ATP-binding site [chemical binding]; other site
744872003652	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
744872003653	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-...; Region: GT1_UGDG_like; cd03817
744872003654	putative ADP-binding pocket [chemical binding]; other site
744872003655	Sodium:solute symporter family; Region: SSF; cl00456
744872003656	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
744872003657	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
744872003658	dimer interface [polypeptide binding]; other site
744872003659	PYR/PP interface [polypeptide binding]; other site
744872003660	TPP binding site [chemical binding]; other site
744872003661	substrate binding site [chemical binding]; other site
744872003662	TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as indolepyruvate or phenylpyruvate, which are generated by the...; Region: TPP_IOR_alpha; cd02008
744872003663	TPP-binding site; other site
744872003664	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
744872003665	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
744872003666	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
744872003667	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
744872003668	ACT domain-containing protein [General function prediction only]; Region: COG4747
744872003669	N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
744872003670	C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882
744872003671	glycogen synthase; Provisional; Region: glgA; PRK00654
744872003672	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
744872003673	ADP-binding pocket [chemical binding]; other site
744872003674	homodimer interface [polypeptide binding]; other site
744872003675	Borrelia P83/100 protein; Region: Borrelia_P83; pfam05262
744872003676	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
744872003677	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
744872003678	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
744872003679	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
744872003680	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
744872003681	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
744872003682	active site
744872003683	NTP binding site [chemical binding]; other site
744872003684	metal binding triad [ion binding]; metal-binding site
744872003685	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
744872003686	Protein of unknown function (DUF1570); Region: DUF1570; pfam07607
744872003687	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872003688	binding surface
744872003689	TPR motif; other site
744872003690	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
744872003691	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
744872003692	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869
744872003693	active site
744872003694	Divergent PAP2 family; Region: DUF212; cl00855
744872003695	sodium/hydrogen exchanger 3; Region: b_cpa1; TIGR00840
744872003696	C subunit; Region: rnfC; TIGR01945
744872003697	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
744872003698	SLBB domain; Region: SLBB; pfam10531
744872003699	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655
744872003700	RnfE family; Region: NQR2_RnfD_RnfE; cl00779
744872003701	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
744872003702	Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074
744872003703	Domain of unknown function (DUF1925); Region: DUF1925; pfam09094
744872003704	Domain of unknown function (DUF1926); Region: DUF1926; pfam09095
744872003705	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
744872003706	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
744872003707	active site
744872003708	HIGH motif; other site
744872003709	KMSKS motif; other site
744872003710	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
744872003711	tRNA binding surface [nucleotide binding]; other site
744872003712	anticodon binding site; other site
744872003713	The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human tyrosyl-; Region: tRNA_bindingDomain; cl00320
744872003714	putative tRNA-binding site [nucleotide binding]; other site
744872003715	Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348
744872003716	FemAB family; Region: FemAB; cl11444
744872003717	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
744872003718	gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522
744872003719	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872003720	Walker A/P-loop; other site
744872003721	ATP binding site [chemical binding]; other site
744872003722	Q-loop/lid; other site
744872003723	ABC transporter signature motif; other site
744872003724	Walker B; other site
744872003725	D-loop; other site
744872003726	H-loop/switch region; other site
744872003727	ABC-2 type transporter; Region: ABC2_membrane; cl11417
744872003728	gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521
744872003729	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
744872003730	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
744872003731	metal binding site [ion binding]; metal-binding site
744872003732	active site
744872003733	I-site; other site
744872003734	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
744872003735	putative ligand binding pocket/active site [active]
744872003736	putative metal binding site [ion binding]; other site
744872003737	Thiamine pyrophosphokinase; Region: TPK; cl09135
744872003738	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604
744872003739	Septum formation initiator; Region: DivIC; cl11433
744872003740	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
744872003741	SmpB-tmRNA interface; other site
744872003742	PEGA domain; Region: PEGA; pfam08308
744872003743	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556
744872003744	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
744872003745	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
744872003746	Catalytic site [active]
744872003747	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
744872003748	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88)...; Region: Peptidase_S24_S26; cl10465
744872003749	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
744872003750	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259
744872003751	HemN C-terminal region; Region: HemN_C; pfam06969
744872003752	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
744872003753	ATP binding site [chemical binding]; other site
744872003754	putative Mg++ binding site [ion binding]; other site
744872003755	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
744872003756	nucleotide binding region [chemical binding]; other site
744872003757	ATP-binding site [chemical binding]; other site
744872003758	Helicase associated domain (HA2); Region: HA2; cl04503
744872003759	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
744872003760	pyruvate phosphate dikinase; Provisional; Region: PRK09279
744872003761	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
744872003762	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
744872003763	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
744872003764	Putative periplasminc binding protein (DUF178); Region: DUF178; cl15271
744872003765	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
744872003766	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872003767	dimer interface [polypeptide binding]; other site
744872003768	conserved gate region; other site
744872003769	putative PBP binding loops; other site
744872003770	ABC-ATPase subunit interface; other site
744872003771	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
744872003772	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293
744872003773	Walker A/P-loop; other site
744872003774	ATP binding site [chemical binding]; other site
744872003775	Q-loop/lid; other site
744872003776	ABC transporter signature motif; other site
744872003777	Walker B; other site
744872003778	D-loop; other site
744872003779	H-loop/switch region; other site
744872003780	Cobalt transport protein; Region: CbiQ; cl00463
744872003781	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
744872003782	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This...; Region: ABC_cobalt_CbiO_domain1; cd03225
744872003783	Walker A/P-loop; other site
744872003784	ATP binding site [chemical binding]; other site
744872003785	Q-loop/lid; other site
744872003786	ABC transporter signature motif; other site
744872003787	Walker B; other site
744872003788	D-loop; other site
744872003789	H-loop/switch region; other site
744872003790	BioY family; Region: BioY; cl00560
744872003791	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
744872003792	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
744872003793	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
744872003794	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
744872003795	putative active site [active]
744872003796	catalytic triad [active]
744872003797	putative dimer interface [polypeptide binding]; other site
744872003798	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
744872003799	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
744872003800	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872003801	binding surface
744872003802	TPR motif; other site
744872003803	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
744872003804	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872003805	binding surface
744872003806	TPR motif; other site
744872003807	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872003808	binding surface
744872003809	TPR motif; other site
744872003810	Uncharacterized conserved protein [Function unknown]; Region: COG3391
744872003811	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
744872003812	catalytic residues [active]
744872003813	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
744872003814	THUMP domain; Region: THUMP; cl12076
744872003815	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
744872003816	Ligand Binding Site [chemical binding]; other site
744872003817	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
744872003818	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
744872003819	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
744872003820	catalytic residue [active]
744872003821	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
744872003822	dimerization interface [polypeptide binding]; other site
744872003823	putative DNA binding site [nucleotide binding]; other site
744872003824	putative Zn2+ binding site [ion binding]; other site
744872003825	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
744872003826	AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243
744872003827	putative catalytic residues [active]
744872003828	nucleotide binding site [chemical binding]; other site
744872003829	aspartate binding site [chemical binding]; other site
744872003830	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
744872003831	dimer interface [polypeptide binding]; other site
744872003832	putative threonine allosteric regulatory site; other site
744872003833	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
744872003834	putative threonine allosteric regulatory site; other site
744872003835	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872003836	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
744872003837	aspartate aminotransferase; Provisional; Region: PRK06836
744872003838	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
744872003839	pyridoxal 5'-phosphate binding site [chemical binding]; other site
744872003840	homodimer interface [polypeptide binding]; other site
744872003841	catalytic residue [active]
744872003842	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
744872003843	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
744872003844	Mg++ binding site [ion binding]; other site
744872003845	putative catalytic motif [active]
744872003846	substrate binding site [chemical binding]; other site
744872003847	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
744872003848	putative transposase OrfB; Reviewed; Region: PHA02517
744872003849	Transposase; Region: HTH_Tnp_Tc3_2; pfam01498
744872003850	Integrase core domain; Region: rve; cl01316
744872003851	Cupin domain; Region: Cupin_2; cl09118
744872003852	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
744872003853	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
744872003854	NADP binding site [chemical binding]; other site
744872003855	active site
744872003856	putative substrate binding site [chemical binding]; other site
744872003857	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
744872003858	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
744872003859	NAD binding site [chemical binding]; other site
744872003860	substrate binding site [chemical binding]; other site
744872003861	homodimer interface [polypeptide binding]; other site
744872003862	active site
744872003863	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
744872003864	active site
744872003865	NTP binding site [chemical binding]; other site
744872003866	metal binding triad [ion binding]; metal-binding site
744872003867	antibiotic binding site [chemical binding]; other site
744872003868	cytidylyltransferase; Region: cytidylyltransferase; cd02170
744872003869	active site
744872003870	PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513
744872003871	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
744872003872	tetramer interface [polypeptide binding]; other site
744872003873	active site
744872003874	Mg2+/Mn2+ binding site [ion binding]; other site
744872003875	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
744872003876	phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297
744872003877	PYR/PP interface [polypeptide binding]; other site
744872003878	dimer interface [polypeptide binding]; other site
744872003879	TPP binding site [chemical binding]; other site
744872003880	TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as bialaphos tripeptide in Streptomyces hygroscopicus...; Region: TPP_PpyrDC; cd03371
744872003881	TPP-binding site; other site
744872003882	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
744872003883	active site
744872003884	metal binding site [ion binding]; metal-binding site
744872003885	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
744872003886	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
744872003887	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
744872003888	catalytic residue [active]
744872003889	histidyl-tRNA synthetase; Region: hisS; TIGR00442
744872003890	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
744872003891	dimer interface [polypeptide binding]; other site
744872003892	motif 1; other site
744872003893	active site
744872003894	motif 2; other site
744872003895	motif 3; other site
744872003896	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
744872003897	anticodon binding site; other site
744872003898	Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130
744872003899	NeuB family; Region: NeuB; cl00496
744872003900	SAF domain; Region: SAF; cl00555
744872003901	Domain of unknown function DUF28; Region: DUF28; cl00361
744872003902	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529
744872003903	active site
744872003904	putative DNA-binding cleft [nucleotide binding]; other site
744872003905	dimer interface [polypeptide binding]; other site
744872003906	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
744872003907	RuvA N terminal domain; Region: RuvA_N; pfam01330
744872003908	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
744872003909	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
744872003910	Walker A motif; other site
744872003911	ATP binding site [chemical binding]; other site
744872003912	Walker B motif; other site
744872003913	arginine finger; other site
744872003914	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
744872003915	Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
744872003916	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
744872003917	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
744872003918	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672
744872003919	TMP-binding site; other site
744872003920	ATP-binding site [chemical binding]; other site
744872003921	Family of unknown function (DUF490); Region: DUF490; pfam04357
744872003922	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
744872003923	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
744872003924	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
744872003925	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
744872003926	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
744872003927	Surface antigen; Region: Bac_surface_Ag; cl03097
744872003928	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
744872003929	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
744872003930	anti sigma factor interaction site; other site
744872003931	regulatory phosphorylation site [posttranslational modification]; other site
744872003932	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
744872003933	MutS domain I; Region: MutS_I; pfam01624
744872003934	MutS domain II; Region: MutS_II; pfam05188
744872003935	MutS family domain IV; Region: MutS_IV; pfam05190
744872003936	MutS1 homolog in eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch.  Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284
744872003937	Walker A/P-loop; other site
744872003938	ATP binding site [chemical binding]; other site
744872003939	Q-loop/lid; other site
744872003940	ABC transporter signature motif; other site
744872003941	Walker B; other site
744872003942	D-loop; other site
744872003943	H-loop/switch region; other site
744872003944	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
744872003945	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
744872003946	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779
744872003947	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members...; Region: Sm_like; cl00259
744872003948	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members...; Region: Sm_like; cl00259
744872003949	Sm1 motif; other site
744872003950	D3 - B interaction site; other site
744872003951	D1 - D2 interaction site; other site
744872003952	Hfq - Hfq interaction site; other site
744872003953	RNA binding pocket [nucleotide binding]; other site
744872003954	Sm2 motif; other site
744872003955	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
744872003956	NusA N-terminal domain; Region: NusA_N; pfam08529
744872003957	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455
744872003958	RNA binding site [nucleotide binding]; other site
744872003959	homodimer interface [polypeptide binding]; other site
744872003960	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
744872003961	G-X-X-G motif; other site
744872003962	Uncharacterised protein family UPF0547; Region: UPF0547; pfam10571
744872003963	translation initiation factor IF-2; Region: IF-2; TIGR00487
744872003964	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
744872003965	IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily.  IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits.  As seen in other GTPases...; Region: IF2_eIF5B; cd01887
744872003966	G1 box; other site
744872003967	putative GEF interaction site [polypeptide binding]; other site
744872003968	GTP/Mg2+ binding site [chemical binding]; other site
744872003969	Switch I region; other site
744872003970	G2 box; other site
744872003971	G3 box; other site
744872003972	Switch II region; other site
744872003973	G4 box; other site
744872003974	G5 box; other site
744872003975	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702
744872003976	Translation-initiation factor 2; Region: IF-2; pfam11987
744872003977	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692
744872003978	Ribosome-binding factor A; Region: RBFA; cl00542
744872003979	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130
744872003980	PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573
744872003981	RNA binding site [nucleotide binding]; other site
744872003982	active site
744872003983	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353
744872003984	16S/18S rRNA binding site [nucleotide binding]; other site
744872003985	S13e-L30e interaction site [polypeptide binding]; other site
744872003986	25S rRNA binding site [nucleotide binding]; other site
744872003987	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
744872003988	3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138
744872003989	3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725
744872003990	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
744872003991	3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138
744872003992	3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725
744872003993	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
744872003994	putative nucleic acid binding region [nucleotide binding]; other site
744872003995	G-X-X-G motif; other site
744872003996	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472
744872003997	RNA binding site [nucleotide binding]; other site
744872003998	domain interface; other site
744872003999	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
744872004000	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
744872004001	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
744872004002	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
744872004003	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
744872004004	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
744872004005	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
744872004006	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
744872004007	Queuine tRNA-ribosyltransferase; Region: TGT; cl00409
744872004008	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
744872004009	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
744872004010	metal ion-dependent adhesion site (MIDAS); other site
744872004011	transcript cleavage factor/unknown domain fusion protein; Provisional; Region: PRK14720
744872004012	domain; Region: GreA_GreB_N; pfam03449
744872004013	C-term; Region: GreA_GreB; pfam01272
744872004014	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429
744872004015	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
744872004016	substrate binding site [chemical binding]; other site
744872004017	hexamer interface [polypeptide binding]; other site
744872004018	metal binding site [ion binding]; metal-binding site
744872004019	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
744872004020	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872004021	binding surface
744872004022	TPR motif; other site
744872004023	ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the...; Region: ADP_ribosyl; cl00283
744872004024	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872004025	binding surface
744872004026	TPR motif; other site
744872004027	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but...; Region: Dtyr_deacylase; cd00563
744872004028	putative active site [active]
744872004029	dimerization interface [polypeptide binding]; other site
744872004030	putative tRNAtyr binding site [nucleotide binding]; other site
744872004031	Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462
744872004032	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
744872004033	recombinase A; Provisional; Region: recA; PRK09354
744872004034	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
744872004035	hexamer interface [polypeptide binding]; other site
744872004036	Walker A motif; other site
744872004037	ATP binding site [chemical binding]; other site
744872004038	Walker B motif; other site
744872004039	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
744872004040	catalytic center binding site [active]
744872004041	ATP binding site [chemical binding]; other site
744872004042	ScpA/B protein; Region: ScpA_ScpB; cl00598
744872004043	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
744872004044	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
744872004045	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
744872004046	RNA binding surface [nucleotide binding]; other site
744872004047	Pseudouridine synthases  are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870
744872004048	active site
744872004049	cytidylate kinase; Provisional; Region: cmk; PRK00023
744872004050	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
744872004051	CMP-binding site; other site
744872004052	The sites determining sugar specificity; other site
744872004053	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
744872004054	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
744872004055	RNA binding site [nucleotide binding]; other site
744872004056	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688
744872004057	RNA binding site [nucleotide binding]; other site
744872004058	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927
744872004059	RNA binding site [nucleotide binding]; other site
744872004060	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927
744872004061	RNA binding site [nucleotide binding]; other site
744872004062	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927
744872004063	RNA binding site [nucleotide binding]; other site
744872004064	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
744872004065	GAF domain; Region: GAF; cl00853
744872004066	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
744872004067	Walker A motif; other site
744872004068	ATP binding site [chemical binding]; other site
744872004069	Walker B motif; other site
744872004070	arginine finger; other site
744872004071	Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
744872004072	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
744872004073	CHASE2 domain; Region: CHASE2; cl01732
744872004074	CHASE2 domain; Region: CHASE2; cl01732
744872004075	cyclase homology domain; Region: CHD; cd07302
744872004076	nucleotidyl binding site; other site
744872004077	metal binding site [ion binding]; metal-binding site
744872004078	dimer interface [polypeptide binding]; other site
744872004079	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
744872004080	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259
744872004081	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090
744872004082	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
744872004083	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
744872004084	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
744872004085	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
744872004086	rod shape-determining protein MreD; Region: MreD; cl01087
744872004087	rod shape-determining protein MreC; Provisional; Region: PRK13922
744872004088	rod shape-determining protein MreC; Region: MreC; pfam04085
744872004089	rod shape-determining protein MreB; Provisional; Region: PRK13927
744872004090	Cell division protein FtsA; Region: FtsA; cl11496
744872004091	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872004092	TPR motif; other site
744872004093	binding surface
744872004094	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429
744872004095	TPR motif; other site
744872004096	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
744872004097	Putative zinc ribbon domain; Region: DUF164; pfam02591
744872004098	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
744872004099	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
744872004100	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
744872004101	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
744872004102	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
744872004103	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
744872004104	DNA binding residues [nucleotide binding]
744872004105	DNA primase, catalytic core; Region: dnaG; TIGR01391
744872004106	CHC2 zinc finger; Region: zf-CHC2; cl02597
744872004107	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
744872004108	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
744872004109	active site
744872004110	metal binding site [ion binding]; metal-binding site
744872004111	interdomain interaction site; other site
744872004112	YceG-like family; Region: YceG; pfam02618
744872004113	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
744872004114	dimerization interface [polypeptide binding]; other site
744872004115	Flagellar hook capping protein; Region: FlgD; cl04347
744872004116	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
744872004117	Flagellin N-methylase; Region: FliB; cl00497
744872004118	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In...; Region: AroH; cd02185
744872004119	homotrimer interaction site [polypeptide binding]; other site
744872004120	active site
744872004121	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
744872004122	nucleotide binding site/active site [active]
744872004123	HIT family signature motif; other site
744872004124	catalytic residue [active]
744872004125	Thiamine pyrophosphokinase; Region: TPK; cd07995
744872004126	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
744872004127	active site
744872004128	dimerization interface [polypeptide binding]; other site
744872004129	thiamine binding site [chemical binding]; other site
744872004130	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
744872004131	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
744872004132	active site
744872004133	NTP binding site [chemical binding]; other site
744872004134	metal binding triad [ion binding]; metal-binding site
744872004135	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
744872004136	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
744872004137	ribonuclease III; Reviewed; Region: rnc; PRK00102
744872004138	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593
744872004139	dimerization interface [polypeptide binding]; other site
744872004140	active site
744872004141	metal binding site [ion binding]; metal-binding site
744872004142	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048
744872004143	Phosphopantetheine attachment site; Region: PP-binding; cl09936
744872004144	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
744872004145	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
744872004146	active site
744872004147	(T/H)XGH motif; other site
744872004148	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
744872004149	Protein of unknown function DUF72; Region: DUF72; cl00777
744872004150	DNA polymerase IV; Validated; Region: PRK01810
744872004151	Y-family of DNA polymerases; Region: PolY; cl12025
744872004152	active site
744872004153	DNA binding site [nucleotide binding]
744872004154	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
744872004155	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
744872004156	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
744872004157	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485
744872004158	generic binding surface II; other site
744872004159	generic binding surface I; other site
744872004160	Maf-like protein; Region: Maf; pfam02545
744872004161	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
744872004162	active site
744872004163	dimer interface [polypeptide binding]; other site
744872004164	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
744872004165	rRNA interaction site [nucleotide binding]; other site
744872004166	S8 interaction site; other site
744872004167	putative laminin-1 binding site; other site
744872004168	elongation factor Ts; Provisional; Region: tsf; PRK09377
744872004169	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
744872004170	Elongation factor TS; Region: EF_TS; pfam00889
744872004171	Elongation factor TS; Region: EF_TS; pfam00889
744872004172	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520
744872004173	hinge region; other site
744872004174	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
744872004175	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
744872004176	catalytic residue [active]
744872004177	putative FPP diphosphate  binding site; other site
744872004178	putative FPP binding hydrophobic cleft; other site
744872004179	dimer interface [polypeptide binding]; other site
744872004180	putative IPP diphosphate binding site; other site
744872004181	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
744872004182	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
744872004183	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
744872004184	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
744872004185	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
744872004186	active site
744872004187	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989
744872004188	protein binding site [polypeptide binding]; other site
744872004189	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989
744872004190	protein binding site [polypeptide binding]; other site
744872004191	Late competence development protein ComFB; Region: ComFB; pfam10719
744872004192	replicative DNA helicase; Region: DnaB; TIGR00665
744872004193	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
744872004194	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
744872004195	Walker A motif; other site
744872004196	ATP binding site [chemical binding]; other site
744872004197	Walker B motif; other site
744872004198	DNA binding loops [nucleotide binding]
744872004199	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
744872004200	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
744872004201	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
744872004202	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
744872004203	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
744872004204	dimer interface [polypeptide binding]; other site
744872004205	ssDNA binding site [nucleotide binding]; other site
744872004206	tetramer (dimer of dimers) interface [polypeptide binding]; other site
744872004207	Ribosomal protein S6; Region: Ribosomal_S6; cl00414
744872004208	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
744872004209	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
744872004210	S-adenosylmethionine binding site [chemical binding]; other site
744872004211	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872004212	binding surface
744872004213	TPR motif; other site
744872004214	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872004215	binding surface
744872004216	TPR motif; other site
744872004217	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872004218	binding surface
744872004219	TPR motif; other site
744872004220	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872004221	binding surface
744872004222	TPR motif; other site
744872004223	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
744872004224	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
744872004225	FeS/SAM binding site; other site
744872004226	Protein of unknown function (DUF445); Region: DUF445; pfam04286
744872004227	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
744872004228	active site
744872004229	8-oxo-dGMP binding site [chemical binding]; other site
744872004230	nudix motif; other site
744872004231	metal binding site [ion binding]; metal-binding site
744872004232	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
744872004233	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
744872004234	putative substrate binding site [chemical binding]; other site
744872004235	putative ATP binding site [chemical binding]; other site
744872004236	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
744872004237	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
744872004238	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
744872004239	nucleotide binding region [chemical binding]; other site
744872004240	ATP-binding site [chemical binding]; other site
744872004241	hypothetical protein; Provisional; Region: PRK10396
744872004242	SEC-C motif; Region: SEC-C; cl12132
744872004243	ribonuclease E; Reviewed; Region: rne; PRK10811
744872004244	Sporulation related domain; Region: SPOR; cl10051
744872004245	Transcription antiterminator [Transcription]; Region: NusG; COG0250
744872004246	N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766
744872004247	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872004248	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
744872004249	Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719
744872004250	NAD(P) binding site [chemical binding]; other site
744872004251	homodimer interface [polypeptide binding]; other site
744872004252	substrate binding site [chemical binding]; other site
744872004253	active site
744872004254	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
744872004255	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
744872004256	inhibitor-cofactor binding pocket; inhibition site
744872004257	pyridoxal 5'-phosphate binding site [chemical binding]; other site
744872004258	catalytic residue [active]
744872004259	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
744872004260	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161
744872004261	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
744872004262	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
744872004263	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
744872004264	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
744872004265	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
744872004266	active site
744872004267	dimer interface [polypeptide binding]; other site
744872004268	metal binding site [ion binding]; metal-binding site
744872004269	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872004270	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
744872004271	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
744872004272	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872004273	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
744872004274	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
744872004275	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872004276	Walker A/P-loop; other site
744872004277	ATP binding site [chemical binding]; other site
744872004278	Q-loop/lid; other site
744872004279	ABC transporter signature motif; other site
744872004280	Walker B; other site
744872004281	D-loop; other site
744872004282	H-loop/switch region; other site
744872004283	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
744872004284	active site
744872004285	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
744872004286	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
744872004287	LicD family; Region: LicD; cl01378
744872004288	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
744872004289	Transposase domain (DUF772); Region: DUF772; cl12084
744872004290	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
744872004291	putative ADP-binding pocket [chemical binding]; other site
744872004292	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
744872004293	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
744872004294	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
744872004295	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
744872004296	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
744872004297	putative NAD(P) binding site [chemical binding]; other site
744872004298	active site
744872004299	putative substrate binding site [chemical binding]; other site
744872004300	Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022
744872004301	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
744872004302	Bacterial sugar transferase; Region: Bac_transf; cl00939
744872004303	flagellar rod assembly protein/muramidase FlgJ; Reviewed; Region: flgJ; PRK12711
744872004304	Rod binding protein; Region: Rod-binding; cl01626
744872004305	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12816
744872004306	Flagella basal body rod protein; Region: Flg_bb_rod; cl15245
744872004307	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
744872004308	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
744872004309	Flagella basal body rod protein; Region: Flg_bb_rod; cl15245
744872004310	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
744872004311	EamA-like transporter family; Region: EamA; cl01037
744872004312	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
744872004313	EamA-like transporter family; Region: EamA; cl01037
744872004314	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
744872004315	proposed active site lysine [active]
744872004316	conserved cys residue [active]
744872004317	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
744872004318	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
744872004319	ATP binding site [chemical binding]; other site
744872004320	putative Mg++ binding site [ion binding]; other site
744872004321	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
744872004322	nucleotide binding region [chemical binding]; other site
744872004323	ATP-binding site [chemical binding]; other site
744872004324	Helicase associated domain (HA2); Region: HA2; cl04503
744872004325	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
744872004326	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
744872004327	DNA ligase, NAD-dependent; Region: dnlj; TIGR00575
744872004328	nucleotide binding pocket [chemical binding]; other site
744872004329	K-X-D-G motif; other site
744872004330	catalytic site [active]
744872004331	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
744872004332	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027
744872004333	Dimer interface [polypeptide binding]; other site
744872004334	BRCT sequence motif; other site
744872004335	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
744872004336	photolyase PhrII; Region: phr2; TIGR00591
744872004337	DNA photolyase; Region: DNA_photolyase; pfam00875
744872004338	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
744872004339	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide...; Region: NrdH; cd02976
744872004340	catalytic residues [active]
744872004341	Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977
744872004342	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
744872004343	Protein of unknown function (DUF503); Region: DUF503; cl00669
744872004344	FecR protein; Region: FecR; pfam04773
744872004345	poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939
744872004346	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872004347	binding surface
744872004348	TPR motif; other site
744872004349	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
744872004350	GcpE protein; Region: GcpE; pfam04551
744872004351	1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612
744872004352	V-type ATP synthase subunit K; Validated; Region: PRK06649
744872004353	V-type ATP synthase subunit I; Validated; Region: PRK05771
744872004354	ATP synthase subunit D; Region: ATP-synt_D; cl00613
744872004355	V-type ATP synthase subunit B; Provisional; Region: PRK02118
744872004356	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
744872004357	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the...; Region: V_A-ATPase_B; cd01135
744872004358	Walker A motif homologous position; other site
744872004359	Walker B motif; other site
744872004360	V-type ATP synthase subunit A; Provisional; Region: PRK04192
744872004361	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
744872004362	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
744872004363	Walker A motif/ATP binding site; other site
744872004364	Walker B motif; other site
744872004365	Protein of unknown function (DUF2764); Region: DUF2764; pfam10962
744872004366	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
744872004367	Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017
744872004368	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
744872004369	active site
744872004370	catalytic residues [active]
744872004371	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257
744872004372	HSP70 interaction site [polypeptide binding]; other site
744872004373	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
744872004374	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872004375	active site
744872004376	phosphorylation site [posttranslational modification]
744872004377	intermolecular recognition site; other site
744872004378	dimerization interface [polypeptide binding]; other site
744872004379	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
744872004380	Walker A motif; other site
744872004381	ATP binding site [chemical binding]; other site
744872004382	Walker B motif; other site
744872004383	arginine finger; other site
744872004384	Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
744872004385	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
744872004386	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
744872004387	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
744872004388	dimer interface [polypeptide binding]; other site
744872004389	phosphorylation site [posttranslational modification]
744872004390	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872004391	ATP binding site [chemical binding]; other site
744872004392	G-X-G motif; other site
744872004393	ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470
744872004394	DNA polymerase III subunit delta'; Validated; Region: PRK05707
744872004395	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872004396	Colicin V production protein; Region: Colicin_V; cl00567
744872004397	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
744872004398	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785
744872004399	active site
744872004400	homodimer interface [polypeptide binding]; other site
744872004401	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
744872004402	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
744872004403	cyclase homology domain; Region: CHD; cd07302
744872004404	nucleotidyl binding site; other site
744872004405	metal binding site [ion binding]; metal-binding site
744872004406	dimer interface [polypeptide binding]; other site
744872004407	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
744872004408	Protein of unknown function (DUF342); Region: DUF342; pfam03961
744872004409	RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288
744872004410	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
744872004411	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
744872004412	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
744872004413	DNA binding residues [nucleotide binding]
744872004414	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
744872004415	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
744872004416	P-loop; other site
744872004417	flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12723
744872004418	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
744872004419	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
744872004420	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
744872004421	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
744872004422	Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017
744872004423	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
744872004424	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
744872004425	FliP family; Region: FliP; cl00593
744872004426	Flagellar biosynthesis protein, FliO; Region: FliO; cl01247
744872004427	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
744872004428	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
744872004429	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
744872004430	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
744872004431	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
744872004432	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
744872004433	flagellar motor protein MotB; Validated; Region: motB; PRK06667
744872004434	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
744872004435	ligand binding site [chemical binding]; other site
744872004436	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
744872004437	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
744872004438	Flagellar protein (FlbD); Region: FlbD; cl00683
744872004439	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
744872004440	Flagella basal body rod protein; Region: Flg_bb_rod; cl15245
744872004441	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
744872004442	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
744872004443	Domain of unknown function (DUF1078); Region: DUF1078; pfam06429
744872004444	Flagellar hook capping protein; Region: FlgD; cl04347
744872004445	Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269
744872004446	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
744872004447	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
744872004448	putative active site [active]
744872004449	putative metal binding site [ion binding]; other site
744872004450	Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983
744872004451	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227
744872004452	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
744872004453	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
744872004454	pfkB family carbohydrate kinase; Region: PfkB; pfam00294
744872004455	substrate binding site [chemical binding]; other site
744872004456	ATP binding site [chemical binding]; other site
744872004457	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
744872004458	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
744872004459	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872004460	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
744872004461	Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar rhodanese-...; Region: RHOD_Pyr_redox; cd01524
744872004462	active site residue [active]
744872004463	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-...; Region: SirA_YedF_YeeD; cl00436
744872004464	CPxP  motif; other site
744872004465	DsrE/DsrF-like family; Region: DrsE; cl00672
744872004466	aspartate kinase; Provisional; Region: PRK06291
744872004467	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
744872004468	nucleotide binding site [chemical binding]; other site
744872004469	substrate binding site [chemical binding]; other site
744872004470	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141
744872004471	ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892
744872004472	Domain of unknown function DUF39; Region: DUF39; cl14897
744872004473	NIL domain; Region: NIL; cl09633
744872004474	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
744872004475	hypothetical protein; Provisional; Region: PRK13795
744872004476	4Fe-4S binding domain; Region: Fer4; cl02805
744872004477	ApbE family; Region: ApbE; cl00643
744872004478	YcfA-like protein; Region: YcfA; cl00752
744872004479	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
744872004480	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
744872004481	Fe-S cluster binding site [ion binding]; other site
744872004482	active site
744872004483	primosome assembly protein PriA; Validated; Region: PRK05580
744872004484	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
744872004485	ATP binding site [chemical binding]; other site
744872004486	putative Mg++ binding site [ion binding]; other site
744872004487	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872004488	PEGA domain; Region: PEGA; pfam08308
744872004489	PEGA domain; Region: PEGA; pfam08308
744872004490	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
744872004491	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
744872004492	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
744872004493	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872004494	Walker A motif; other site
744872004495	ATP binding site [chemical binding]; other site
744872004496	Walker B motif; other site
744872004497	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
744872004498	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
744872004499	putative dimer interface [polypeptide binding]; other site
744872004500	active site pocket [active]
744872004501	putative cataytic base [active]
744872004502	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
744872004503	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
744872004504	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
744872004505	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
744872004506	dimer interface [polypeptide binding]; other site
744872004507	active site
744872004508	metal binding site [ion binding]; metal-binding site
744872004509	potassium/proton antiporter; Reviewed; Region: PRK05326
744872004510	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
744872004511	CAAX amino terminal protease self- immunity; Region: Abi; cl00558
744872004512	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
744872004513	putative active site [active]
744872004514	homotetrameric interface [polypeptide binding]; other site
744872004515	metal binding site [ion binding]; metal-binding site
744872004516	Transposase domain (DUF772); Region: DUF772; cl12084
744872004517	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
744872004518	Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017
744872004519	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
744872004520	active site
744872004521	catalytic residues [active]
744872004522	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
744872004523	4Fe-4S binding domain; Region: Fer4_5; pfam12801
744872004524	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
744872004525	endonuclease III; Region: ENDO3c; smart00478
744872004526	minor groove reading motif; other site
744872004527	helix-hairpin-helix signature motif; other site
744872004528	substrate binding pocket [chemical binding]; other site
744872004529	active site
744872004530	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
744872004531	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
744872004532	cytidylate kinase; Provisional; Region: PRK04182
744872004533	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
744872004534	CMP-binding site; other site
744872004535	The sites determining sugar specificity; other site
744872004536	hypothetical protein; Provisional; Region: PRK11820
744872004537	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
744872004538	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
744872004539	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
744872004540	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
744872004541	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
744872004542	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
744872004543	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
744872004544	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
744872004545	PAS domain S-box; Region: sensory_box; TIGR00229
744872004546	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
744872004547	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
744872004548	Histidine kinase; Region: HisKA_2; cl06527
744872004549	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
744872004550	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869
744872004551	active site
744872004552	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
744872004553	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
744872004554	RNA binding surface [nucleotide binding]; other site
744872004555	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869
744872004556	active site
744872004557	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
744872004558	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
744872004559	catalytic residue [active]
744872004560	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
744872004561	Competence protein; Region: Competence; cl00471
744872004562	PilZ domain; Region: PilZ; cl01260
744872004563	CAAX amino terminal protease self- immunity; Region: Abi; cl00558
744872004564	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966
744872004565	catalytic residues [active]
744872004566	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515
744872004567	arginine decarboxylase; Provisional; Region: PRK05354
744872004568	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
744872004569	dimer interface [polypeptide binding]; other site
744872004570	active site
744872004571	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
744872004572	catalytic residues [active]
744872004573	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
744872004574	N-carbamolyputrescine amidase; Region: PLN02747
744872004575	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
744872004576	putative active site; other site
744872004577	catalytic triad [active]
744872004578	putative dimer interface [polypeptide binding]; other site
744872004579	agmatine deiminase; Region: agmatine_aguA; TIGR03380
744872004580	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113
744872004581	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
744872004582	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
744872004583	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
744872004584	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872004585	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
744872004586	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
744872004587	transcription termination factor Rho; Provisional; Region: rho; PRK09376
744872004588	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
744872004589	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent...; Region: Rho_CSD; cd04459
744872004590	RNA binding site [nucleotide binding]; other site
744872004591	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128
744872004592	multimer interface [polypeptide binding]; other site
744872004593	Walker A motif; other site
744872004594	ATP binding site [chemical binding]; other site
744872004595	Walker B motif; other site
744872004596	Competence-damaged protein; Region: CinA; cl00666
744872004597	Polymer-forming cytoskeletal; Region: Bactofilin; cl09137
744872004598	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429
744872004599	Response regulator receiver domain; Region: Response_reg; pfam00072
744872004600	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872004601	active site
744872004602	phosphorylation site [posttranslational modification]
744872004603	intermolecular recognition site; other site
744872004604	dimerization interface [polypeptide binding]; other site
744872004605	Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815
744872004606	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
744872004607	putative active site [active]
744872004608	catalytic triad [active]
744872004609	putative dimer interface [polypeptide binding]; other site
744872004610	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591
744872004611	IHF - DNA interface [nucleotide binding]; other site
744872004612	IHF dimer interface [polypeptide binding]; other site
744872004613	Ribosomal protein S20; Region: Ribosomal_S20p; cl00384
744872004614	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
744872004615	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
744872004616	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
744872004617	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872004618	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
744872004619	synthetase active site [active]
744872004620	NTP binding site [chemical binding]; other site
744872004621	metal binding site [ion binding]; metal-binding site
744872004622	mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); Region: 3a0801s09; TIGR00990
744872004623	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872004624	binding surface
744872004625	TPR motif; other site
744872004626	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
744872004627	putative acyl-acceptor binding pocket; other site
744872004628	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
744872004629	CarD-like/TRCF domain; Region: CarD_TRCF; cl00588
744872004630	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
744872004631	ATP binding site [chemical binding]; other site
744872004632	putative Mg++ binding site [ion binding]; other site
744872004633	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
744872004634	nucleotide binding region [chemical binding]; other site
744872004635	ATP-binding site [chemical binding]; other site
744872004636	TRCF domain; Region: TRCF; cl04088
744872004637	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
744872004638	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281
744872004639	active site
744872004640	DNA topoisomerase IV subunit A; Provisional; Region: PRK09631
744872004641	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cl00148
744872004642	CAP-like domain; other site
744872004643	Active site [active]
744872004644	primary dimer interface [polypeptide binding]; other site
744872004645	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
744872004646	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872004647	ATP binding site [chemical binding]; other site
744872004648	Mg2+ binding site [ion binding]; other site
744872004649	G-X-G motif; other site
744872004650	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822
744872004651	anchoring element; other site
744872004652	dimer interface [polypeptide binding]; other site
744872004653	ATP binding site [chemical binding]; other site
744872004654	TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both...; Region: TOPRIM_TopoIIA_like; cd01030
744872004655	active site
744872004656	putative metal-binding site [ion binding]; other site
744872004657	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
744872004658	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
744872004659	Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase).  The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA.  This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G_bact; cd04170
744872004660	elongation factor G; Reviewed; Region: PRK12740
744872004661	G1 box; other site
744872004662	putative GEF interaction site [polypeptide binding]; other site
744872004663	GTP/Mg2+ binding site [chemical binding]; other site
744872004664	Switch I region; other site
744872004665	G2 box; other site
744872004666	G3 box; other site
744872004667	Switch II region; other site
744872004668	G4 box; other site
744872004669	G5 box; other site
744872004670	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088
744872004671	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434
744872004672	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713
744872004673	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the...; Region: citrate_synt_like_1_2; cd06113
744872004674	dimer interface [polypeptide binding]; other site
744872004675	active site
744872004676	citrylCoA binding site [chemical binding]; other site
744872004677	Citrate synthase; Region: Citrate_synt; pfam00285
744872004678	oxalacetate/citrate binding site [chemical binding]; other site
744872004679	coenzyme A binding site [chemical binding]; other site
744872004680	catalytic triad [active]
744872004681	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
744872004682	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (...; Region: EcAsnRS_like_N; cd04318
744872004683	putative dimer interface [polypeptide binding]; other site
744872004684	putative anticodon binding site; other site
744872004685	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well...; Region: AsxRS_core; cd00776
744872004686	homodimer interface [polypeptide binding]; other site
744872004687	motif 1; other site
744872004688	motif 2; other site
744872004689	active site
744872004690	motif 3; other site
744872004691	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
744872004692	Beta-lactamase; Region: Beta-lactamase; cl01009
744872004693	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814
744872004694	Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620
744872004695	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
744872004696	active site
744872004697	metal binding site [ion binding]; metal-binding site
744872004698	Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439
744872004699	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
744872004700	Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980
744872004701	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
744872004702	S-adenosylmethionine binding site [chemical binding]; other site
744872004703	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
744872004704	active site
744872004705	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
744872004706	active site
744872004707	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
744872004708	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
744872004709	FeS/SAM binding site; other site
744872004710	radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085
744872004711	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
744872004712	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489
744872004713	generic binding surface II; other site
744872004714	generic binding surface I; other site
744872004715	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
744872004716	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
744872004717	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
744872004718	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
744872004719	ATP binding site [chemical binding]; other site
744872004720	MutL C terminal dimerisation domain; Region: MutL_C; cl07336
744872004721	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
744872004722	putative deoxyribonuclease YjjV; Provisional; Region: PRK11449
744872004723	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
744872004724	active site
744872004725	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
744872004726	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655
744872004727	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
744872004728	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
744872004729	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
744872004730	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412
744872004731	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
744872004732	Nif-specific regulatory protein; Region: nifA; TIGR01817
744872004733	GAF domain; Region: GAF; cl00853
744872004734	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
744872004735	Walker A motif; other site
744872004736	ATP binding site [chemical binding]; other site
744872004737	Walker B motif; other site
744872004738	arginine finger; other site
744872004739	Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
744872004740	Carbon starvation protein CstA; Region: CstA; cl00856
744872004741	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
744872004742	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
744872004743	ATP binding site [chemical binding]; other site
744872004744	dimerization interface [polypeptide binding]; other site
744872004745	Metal binding site [ion binding]; metal-binding site
744872004746	Predicted transcriptional regulators [Transcription]; Region: COG1725
744872004747	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
744872004748	DNA-binding site [nucleotide binding]; DNA binding site
744872004749	B12 binding domain of glutamate mutase (Glm). Glutamate mutase catalysis the conversion of (S)-glutamate with (2S,3S)-3-methylaspartate. The rearrangement reaction is initiated by the extraction of a hydrogen from the protein-bound substrate by a 5'-...; Region: Glm_B12_BD; cd02072
744872004750	B12 binding site [chemical binding]; other site
744872004751	heterodimer interface [polypeptide binding]; other site
744872004752	cobalt ligand [ion binding]; other site
744872004753	conserved hypothetical protein; Region: glmL_fam; TIGR01319
744872004754	Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to L-threo-; Region: Glm_e; cd00245
744872004755	substrate binding site [chemical binding]; other site
744872004756	B12 cofactor binding site [chemical binding]; other site
744872004757	heterodimer (sigma-epsilon) interface [polypeptide binding]; other site
744872004758	homodimer (epsilon-epsilon) interface [polypeptide binding]; other site
744872004759	Methylaspartate ammonia-lyase [Amino acid transport and metabolism]; Region: Mal; COG3799
744872004760	Methylaspartate ammonia lyase (3-methylaspartase, MAL) is a homodimeric enzyme, catalyzing the magnesium-dependent reversible alpha,beta-elimination of ammonia from L-threo-(2S,3S)-3-methylaspartic acid to mesaconic acid. This reaction is part of the...; Region: MAL; cd03314
744872004761	dimer interface [polypeptide binding]; other site
744872004762	active site
744872004763	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
744872004764	threonyl-tRNA synthetase; Reviewed; Region: PRK12444
744872004765	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
744872004766	Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028
744872004767	Active site [active]
744872004768	Flagellar FliJ protein; Region: FliJ; cl09161
744872004769	flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473
744872004770	flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497
744872004771	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
744872004772	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
744872004773	Walker A motif/ATP binding site; other site
744872004774	Walker B motif; other site
744872004775	Flagellar assembly protein FliH; Region: FliH; pfam02108
744872004776	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
744872004777	FliG C-terminal domain; Region: FliG_C; pfam01706
744872004778	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
744872004779	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
744872004780	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
744872004781	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
744872004782	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
744872004783	Flagella basal body rod protein; Region: Flg_bb_rod; cl15245
744872004784	Domain of unknown function (DUF1078); Region: DUF1078; pfam06429
744872004785	flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12622
744872004786	Flagella basal body rod protein; Region: Flg_bb_rod; cl15245
744872004787	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
744872004788	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
744872004789	Walker A motif; other site
744872004790	ATP binding site [chemical binding]; other site
744872004791	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872004792	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
744872004793	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
744872004794	active site
744872004795	HslU subunit interaction site [polypeptide binding]; other site
744872004796	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
744872004797	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
744872004798	DNA binding site [nucleotide binding]
744872004799	Int/Topo IB signature motif; other site
744872004800	active site
744872004801	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363
744872004802	DNA topoisomerase I; Validated; Region: PRK05582
744872004803	active site
744872004804	interdomain interaction site; other site
744872004805	putative metal-binding site [ion binding]; other site
744872004806	nucleotide binding site [chemical binding]; other site
744872004807	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186
744872004808	domain I; other site
744872004809	DNA binding groove [nucleotide binding]
744872004810	phosphate binding site [ion binding]; other site
744872004811	domain II; other site
744872004812	domain III; other site
744872004813	nucleotide binding site [chemical binding]; other site
744872004814	catalytic site [active]
744872004815	domain IV; other site
744872004816	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977
744872004817	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977
744872004818	DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695
744872004819	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
744872004820	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872004821	TPR motif; other site
744872004822	binding surface
744872004823	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
744872004824	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
744872004825	DNA binding site [nucleotide binding]
744872004826	Int/Topo IB signature motif; other site
744872004827	active site
744872004828	cell division protein FtsZ; Validated; Region: PRK09330
744872004829	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201
744872004830	nucleotide binding site [chemical binding]; other site
744872004831	SulA interaction site; other site
744872004832	cell division protein FtsA; Region: ftsA; TIGR01174
744872004833	Cell division protein FtsA; Region: FtsA; cl11496
744872004834	Cell division protein FtsA; Region: FtsA; cl11496
744872004835	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
744872004836	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
744872004837	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
744872004838	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
744872004839	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852
744872004840	Mg++ binding site [ion binding]; other site
744872004841	putative catalytic motif [active]
744872004842	putative substrate binding site [chemical binding]; other site
744872004843	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
744872004844	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
744872004845	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
744872004846	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
744872004847	Septum formation initiator; Region: DivIC; cl11433
744872004848	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
744872004849	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
744872004850	MraZ protein; Region: MraZ; pfam02381
744872004851	cell division protein MraZ; Reviewed; Region: PRK00326
744872004852	MraZ protein; Region: MraZ; pfam02381
744872004853	Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620
744872004854	Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620
744872004855	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947
744872004856	hypothetical protein; Provisional; Region: PRK08185
744872004857	intersubunit interface [polypeptide binding]; other site
744872004858	active site
744872004859	zinc binding site [ion binding]; other site
744872004860	Na+ binding site [ion binding]; other site
744872004861	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
744872004862	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
744872004863	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
744872004864	Ribosomal protein L35; Region: Ribosomal_L35p; cl00392
744872004865	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
744872004866	23S rRNA binding site [nucleotide binding]; other site
744872004867	L21 binding site [polypeptide binding]; other site
744872004868	L13 binding site [polypeptide binding]; other site
744872004869	Protein of unknown function (DUF904); Region: DUF904; cl11531
744872004870	Cell division protein ZapA; Region: ZapA; cl01146
744872004871	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
744872004872	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
744872004873	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
744872004874	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727
744872004875	GAF domain; Region: GAF; cl00853
744872004876	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
744872004877	Zn2+ binding site [ion binding]; other site
744872004878	Mg2+ binding site [ion binding]; other site
744872004879	PPIC-type PPIASE domain; Region: Rotamase; cl08278
744872004880	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
744872004881	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872004882	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872004883	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
744872004884	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
744872004885	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
744872004886	E3 interaction surface; other site
744872004887	lipoyl attachment site [posttranslational modification]; other site
744872004888	e3 binding domain; Region: E3_binding; pfam02817
744872004889	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
744872004890	pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212
744872004891	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
744872004892	alpha subunit interface [polypeptide binding]; other site
744872004893	TPP binding site [chemical binding]; other site
744872004894	heterodimer interface [polypeptide binding]; other site
744872004895	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
744872004896	pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149
744872004897	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
744872004898	tetramer interface [polypeptide binding]; other site
744872004899	TPP-binding site [chemical binding]; other site
744872004900	heterodimer interface [polypeptide binding]; other site
744872004901	phosphorylation loop region [posttranslational modification]
744872004902	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
744872004903	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
744872004904	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
744872004905	Walker A/P-loop; other site
744872004906	ATP binding site [chemical binding]; other site
744872004907	Q-loop/lid; other site
744872004908	ABC transporter signature motif; other site
744872004909	Walker B; other site
744872004910	D-loop; other site
744872004911	H-loop/switch region; other site
744872004912	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
744872004913	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872004914	dimer interface [polypeptide binding]; other site
744872004915	conserved gate region; other site
744872004916	putative PBP binding loops; other site
744872004917	ABC-ATPase subunit interface; other site
744872004918	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
744872004919	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872004920	dimer interface [polypeptide binding]; other site
744872004921	conserved gate region; other site
744872004922	putative PBP binding loops; other site
744872004923	ABC-ATPase subunit interface; other site
744872004924	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
744872004925	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
744872004926	Integral membrane protein DUF92; Region: DUF92; cl00793
744872004927	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
744872004928	active site lid residues [active]
744872004929	substrate binding pocket [chemical binding]; other site
744872004930	catalytic residues [active]
744872004931	substrate-Mg2+ binding site; other site
744872004932	aspartate-rich region 1; other site
744872004933	aspartate-rich region 2; other site
744872004934	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
744872004935	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872004936	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
744872004937	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
744872004938	catalytic loop [active]
744872004939	iron binding site [ion binding]; other site
744872004940	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron...; Region: FNR_like; cl06868
744872004941	FAD binding pocket [chemical binding]; other site
744872004942	conserved FAD binding motif [chemical binding]; other site
744872004943	phosphate binding motif [ion binding]; other site
744872004944	beta-alpha-beta structure motif; other site
744872004945	NAD binding pocket [chemical binding]; other site
744872004946	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
744872004947	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
744872004948	FMN-binding domain; Region: FMN_bind; cl01081
744872004949	RnfE family; Region: NQR2_RnfD_RnfE; cl00779
744872004950	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
744872004951	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
744872004952	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
744872004953	lipoyl synthase; Provisional; Region: PRK05481
744872004954	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259
744872004955	integron integrase; Region: integrase_gron; TIGR02249
744872004956	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
744872004957	DNA binding site [nucleotide binding]
744872004958	Int/Topo IB signature motif; other site
744872004959	active site
744872004960	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
744872004961	Restriction endonuclease; Region: Mrr_cat; cl00747
744872004962	Protein of unknown function (DUF3788); Region: DUF3788; pfam12663
744872004963	Protein of unknown function (DUF2703); Region: DUF2703; pfam10865
744872004964	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
744872004965	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
744872004966	Transposase domain (DUF772); Region: DUF772; cl12084
744872004967	Phd_YefM; Region: PhdYeFM; cl09153
744872004968	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
744872004969	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
744872004970	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
744872004971	Restriction endonuclease; Region: Mrr_cat; cl00747
744872004972	Phd_YefM; Region: PhdYeFM; cl09153
744872004973	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
744872004974	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
744872004975	active site
744872004976	metal binding site [ion binding]; metal-binding site
744872004977	TfoX N-terminal domain; Region: TfoX_N; cl01167
744872004978	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
744872004979	Restriction endonuclease; Region: Mrr_cat; cl00747
744872004980	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
744872004981	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl00408
744872004982	Phd_YefM; Region: PhdYeFM; cl09153
744872004983	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
744872004984	flagellar basal-body rod protein FlgC; Region: FlgC; TIGR01395
744872004985	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
744872004986	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
744872004987	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
744872004988	active site
744872004989	metal binding site [ion binding]; metal-binding site
744872004990	TfoX N-terminal domain; Region: TfoX_N; cl01167
744872004991	Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300
744872004992	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
744872004993	catalytic core [active]
744872004994	Bacterial SH3 domain; Region: SH3_3; cl02551
744872004995	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
744872004996	Superfamily II helicase [General function prediction only]; Region: COG1204
744872004997	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
744872004998	ATP binding site [chemical binding]; other site
744872004999	putative Mg++ binding site [ion binding]; other site
744872005000	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872005001	Phd_YefM; Region: PhdYeFM; cl09153
744872005002	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
744872005003	CAAX amino terminal protease self- immunity; Region: Abi; cl00558
744872005004	reverse gyrase; Reviewed; Region: PRK09401
744872005005	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
744872005006	putative active site [active]
744872005007	homotetrameric interface [polypeptide binding]; other site
744872005008	metal binding site [ion binding]; metal-binding site
744872005009	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412
744872005010	Transposase, Mutator family; Region: Transposase_mut; pfam00872
744872005011	MULE transposase domain; Region: MULE; pfam10551
744872005012	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987
744872005013	protein binding site [polypeptide binding]; other site
744872005014	Creatinine amidohydrolase; Region: Creatininase; cl00618
744872005015	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
744872005016	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241
744872005017	Walker A/P-loop; other site
744872005018	ATP binding site [chemical binding]; other site
744872005019	Q-loop/lid; other site
744872005020	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241
744872005021	ABC transporter signature motif; other site
744872005022	Walker B; other site
744872005023	D-loop; other site
744872005024	H-loop/switch region; other site
744872005025	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
744872005026	ATP-NAD kinase; Region: NAD_kinase; pfam01513
744872005027	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
744872005028	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
744872005029	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
744872005030	catalytic residue [active]
744872005031	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
744872005032	putative CheA interaction surface; other site
744872005033	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
744872005034	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149
744872005035	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987
744872005036	protein binding site [polypeptide binding]; other site
744872005037	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987
744872005038	protein binding site [polypeptide binding]; other site
744872005039	methionine aminopeptidase; Reviewed; Region: PRK07281
744872005040	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
744872005041	active site
744872005042	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257
744872005043	HSP70 interaction site [polypeptide binding]; other site
744872005044	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
744872005045	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
744872005046	Ligand Binding Site [chemical binding]; other site
744872005047	ATP synthase subunit D; Region: ATP-synt_D; cl00613
744872005048	V-type ATP synthase subunit B; Provisional; Region: PRK04196
744872005049	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
744872005050	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the...; Region: V_A-ATPase_B; cd01135
744872005051	Walker A motif homologous position; other site
744872005052	Walker B motif; other site
744872005053	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
744872005054	V-type ATP synthase subunit A; Provisional; Region: PRK04192
744872005055	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
744872005056	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
744872005057	Walker A motif/ATP binding site; other site
744872005058	Walker B motif; other site
744872005059	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
744872005060	ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; cl00632
744872005061	Archaeal/vacuolar-type H+-ATPase subunit I [Energy production and conversion]; Region: NtpI; COG1269
744872005062	Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527
744872005063	ATP synthase (C/AC39) subunit; Region: vATP-synt_AC39; cl00660
744872005064	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
744872005065	active site
744872005066	phosphorylation site [posttranslational modification]
744872005067	Preprotein translocase SecG subunit; Region: SecG; cl09123
744872005068	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
744872005069	substrate binding site [chemical binding]; other site
744872005070	dimer interface [polypeptide binding]; other site
744872005071	catalytic triad [active]
744872005072	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
744872005073	substrate binding site [chemical binding]; other site
744872005074	hinge regions; other site
744872005075	ADP binding site [chemical binding]; other site
744872005076	catalytic site [active]
744872005077	cytosolic glyceraldehyde 3-phosphate dehydrogenase; Provisional; Region: PTZ00434
744872005078	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267
744872005079	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
744872005080	(p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691
744872005081	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
744872005082	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
744872005083	active site
744872005084	HIGH motif; other site
744872005085	nucleotide binding site [chemical binding]; other site
744872005086	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
744872005087	active site
744872005088	KMSKS motif; other site
744872005089	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
744872005090	tRNA binding surface [nucleotide binding]; other site
744872005091	anticodon binding site; other site
744872005092	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
744872005093	LytB protein; Region: LYTB; cl00507
744872005094	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
744872005095	protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966
744872005096	Protein export membrane protein; Region: SecD_SecF; cl14618
744872005097	protein-export membrane protein SecD; Region: secD; TIGR01129
744872005098	Protein export membrane protein; Region: SecD_SecF; cl14618
744872005099	Preprotein translocase subunit; Region: YajC; cl00806
744872005100	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They...; Region: rubredoxin; cd00730
744872005101	Rubredoxin; Region: Rubredoxin; pfam00301
744872005102	iron binding site [ion binding]; other site
744872005103	desulfoferrodoxin; Region: dfx_rbo; TIGR00320
744872005104	Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small...; Region: DSRD; cd00974
744872005105	non-heme iron binding site [ion binding]; other site
744872005106	dimer interface [polypeptide binding]; other site
744872005107	Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin.  Superoxide reductase-like proteins scavenge superoxide anion...; Region: SORL_Dfx_classI; cd03171
744872005108	non-heme iron binding site [ion binding]; other site
744872005109	dimer interface [polypeptide binding]; other site
744872005110	Rubrerythrin [Energy production and conversion]; Region: COG1592
744872005111	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
744872005112	binuclear metal center [ion binding]; other site
744872005113	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and ferredoxin-...; Region: rubredoxin_SM; cd00729
744872005114	iron binding site [ion binding]; other site
744872005115	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872005116	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
744872005117	TPR motif; other site
744872005118	binding surface
744872005119	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872005120	binding surface
744872005121	TPR motif; other site
744872005122	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
744872005123	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
744872005124	N-acetyl-D-glucosamine binding site [chemical binding]; other site
744872005125	catalytic residue [active]
744872005126	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
744872005127	putative peptidoglycan binding site; other site
744872005128	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
744872005129	putative peptidoglycan binding site; other site
744872005130	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
744872005131	Clp amino terminal domain; Region: Clp_N; pfam02861
744872005132	Clp amino terminal domain; Region: Clp_N; pfam02861
744872005133	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
744872005134	Walker A motif; other site
744872005135	ATP binding site [chemical binding]; other site
744872005136	Walker B motif; other site
744872005137	arginine finger; other site
744872005138	Axonemal dynein light chain; Region: Ax_dynein_light; pfam10211
744872005139	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
744872005140	Walker A motif; other site
744872005141	ATP binding site [chemical binding]; other site
744872005142	Walker B motif; other site
744872005143	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
744872005144	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
744872005145	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
744872005146	active site
744872005147	metal binding site [ion binding]; metal-binding site
744872005148	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
744872005149	CHASE4 domain; Region: CHASE4; cl01308
744872005150	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
744872005151	Histidine kinase; Region: HisKA_2; cl06527
744872005152	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
744872005153	GMP synthase; Reviewed; Region: guaA; PRK00074
744872005154	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
744872005155	AMP/PPi binding site [chemical binding]; other site
744872005156	candidate oxyanion hole; other site
744872005157	catalytic triad [active]
744872005158	potential glutamine specificity residues [chemical binding]; other site
744872005159	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
744872005160	ATP Binding subdomain [chemical binding]; other site
744872005161	Ligand Binding sites [chemical binding]; other site
744872005162	Dimerization subdomain; other site
744872005163	adenylosuccinate synthetase; Provisional; Region: PRK01117
744872005164	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108
744872005165	GDP-binding site [chemical binding]; other site
744872005166	ACT binding site; other site
744872005167	IMP binding site; other site
744872005168	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
744872005169	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
744872005170	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601
744872005171	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381
744872005172	active site
744872005173	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
744872005174	Adenylsuccinate lyase (ASL)_like; Region: Adenylsuccinate_lyase_like; cd01595
744872005175	tetramer interface [polypeptide binding]; other site
744872005176	active site
744872005177	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
744872005178	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
744872005179	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
744872005180	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
744872005181	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
744872005182	active site
744872005183	motif I; other site
744872005184	motif II; other site
744872005185	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
744872005186	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
744872005187	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
744872005188	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872005189	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
744872005190	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The N-...; Region: GltS; cd00713
744872005191	active site
744872005192	dimer interface [polypeptide binding]; other site
744872005193	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
744872005194	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808
744872005195	active site
744872005196	FMN binding site [chemical binding]; other site
744872005197	substrate binding site [chemical binding]; other site
744872005198	3Fe-4S cluster binding site [ion binding]; other site
744872005199	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
744872005200	domain interface; other site
744872005201	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
744872005202	ligand binding site [chemical binding]; other site
744872005203	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
744872005204	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
744872005205	Histidine kinase; Region: His_kinase; pfam06580
744872005206	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872005207	ATP binding site [chemical binding]; other site
744872005208	Mg2+ binding site [ion binding]; other site
744872005209	G-X-G motif; other site
744872005210	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
744872005211	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872005212	active site
744872005213	phosphorylation site [posttranslational modification]
744872005214	intermolecular recognition site; other site
744872005215	dimerization interface [polypeptide binding]; other site
744872005216	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
744872005217	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
744872005218	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
744872005219	Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539
744872005220	ligand binding site [chemical binding]; other site
744872005221	calcium binding site [ion binding]; other site
744872005222	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216
744872005223	galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982
744872005224	Walker A/P-loop; other site
744872005225	ATP binding site [chemical binding]; other site
744872005226	Q-loop/lid; other site
744872005227	ABC transporter signature motif; other site
744872005228	Walker B; other site
744872005229	D-loop; other site
744872005230	H-loop/switch region; other site
744872005231	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215
744872005232	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
744872005233	TM-ABC transporter signature motif; other site
744872005234	DGC domain; Region: DGC; cl01742
744872005235	Predicted permease; Region: DUF318; cl00487
744872005236	hydrogenase maturation GTPase HydF; Region: GTP_HydF; TIGR03918
744872005237	Era (E. coli Ras-like protein)-like.  This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880
744872005238	G1 box; other site
744872005239	GTP/Mg2+ binding site [chemical binding]; other site
744872005240	Switch I region; other site
744872005241	G2 box; other site
744872005242	Switch II region; other site
744872005243	G3 box; other site
744872005244	G4 box; other site
744872005245	G5 box; other site
744872005246	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
744872005247	Lyase; Region: Lyase_1; pfam00206
744872005248	tetramer interface [polypeptide binding]; other site
744872005249	Radical SAM; Region: Elp3; smart00729
744872005250	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
744872005251	FeS/SAM binding site; other site
744872005252	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613
744872005253	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259
744872005254	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
744872005255	putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959
744872005256	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
744872005257	Phd_YefM; Region: PhdYeFM; cl09153
744872005258	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
744872005259	putative active site [active]
744872005260	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729
744872005261	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
744872005262	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
744872005263	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
744872005264	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
744872005265	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
744872005266	active site
744872005267	phosphorylation site [posttranslational modification]
744872005268	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
744872005269	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222
744872005270	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872005271	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
744872005272	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
744872005273	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
744872005274	putative substrate translocation pore; other site
744872005275	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
744872005276	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
744872005277	active site
744872005278	metal binding site [ion binding]; metal-binding site
744872005279	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
744872005280	exonuclease SbcC; Region: sbcc; TIGR00618
744872005281	SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279
744872005282	Walker A/P-loop; other site
744872005283	ATP binding site [chemical binding]; other site
744872005284	Q-loop/lid; other site
744872005285	SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279
744872005286	ABC transporter signature motif; other site
744872005287	Walker B; other site
744872005288	D-loop; other site
744872005289	H-loop/switch region; other site
744872005290	CHASE4 domain; Region: CHASE4; cl01308
744872005291	PAS domain S-box; Region: sensory_box; TIGR00229
744872005292	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
744872005293	putative active site [active]
744872005294	heme pocket [chemical binding]; other site
744872005295	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
744872005296	metal binding site [ion binding]; metal-binding site
744872005297	active site
744872005298	I-site; other site
744872005299	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
744872005300	Isochorismatase family; Region: Isochorismatase; pfam00857
744872005301	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
744872005302	catalytic triad [active]
744872005303	metal binding site [ion binding]; metal-binding site
744872005304	conserved cis-peptide bond; other site
744872005305	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
744872005306	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: NAPRTase_A; cd01570
744872005307	active site
744872005308	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
744872005309	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
744872005310	active site
744872005311	catalytic site [active]
744872005312	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
744872005313	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
744872005314	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872005315	dimer interface [polypeptide binding]; other site
744872005316	conserved gate region; other site
744872005317	ABC-ATPase subunit interface; other site
744872005318	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872005319	dimer interface [polypeptide binding]; other site
744872005320	conserved gate region; other site
744872005321	putative PBP binding loops; other site
744872005322	ABC-ATPase subunit interface; other site
744872005323	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
744872005324	2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834
744872005325	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
744872005326	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
744872005327	substrate binding pocket [chemical binding]; other site
744872005328	membrane-bound complex binding site; other site
744872005329	hinge residues; other site
744872005330	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
744872005331	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872005332	dimer interface [polypeptide binding]; other site
744872005333	conserved gate region; other site
744872005334	putative PBP binding loops; other site
744872005335	ABC-ATPase subunit interface; other site
744872005336	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
744872005337	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This...; Region: Alpha_ANH_like_II; cd01993
744872005338	Ligand Binding Site [chemical binding]; other site
744872005339	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
744872005340	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
744872005341	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
744872005342	putative transporter; Provisional; Region: PRK11462
744872005343	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
744872005344	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
744872005345	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
744872005346	Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074
744872005347	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
744872005348	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
744872005349	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
744872005350	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872005351	dimer interface [polypeptide binding]; other site
744872005352	conserved gate region; other site
744872005353	putative PBP binding loops; other site
744872005354	ABC-ATPase subunit interface; other site
744872005355	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
744872005356	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
744872005357	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
744872005358	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
744872005359	DNA-binding site [nucleotide binding]; DNA binding site
744872005360	Transcriptional regulators [Transcription]; Region: PurR; COG1609
744872005361	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
744872005362	ligand binding site [chemical binding]; other site
744872005363	dimerization interface [polypeptide binding]; other site
744872005364	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
744872005365	active site
744872005366	AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319
744872005367	beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525
744872005368	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
744872005369	domain; Region: Glyco_hydro_2; pfam00703
744872005370	Beta galactosidase small chain; Region: Bgal_small_N; cl03787
744872005371	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
744872005372	DNA-binding site [nucleotide binding]; DNA binding site
744872005373	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
744872005374	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
744872005375	ligand binding site [chemical binding]; other site
744872005376	dimerization interface [polypeptide binding]; other site
744872005377	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cl00195
744872005378	Transposase domain (DUF772); Region: DUF772; cl12084
744872005379	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
744872005380	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721
744872005381	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
744872005382	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
744872005383	CRISPR-associated protein Cas8c/Csd1, subtype I-C/DVULG; Region: cas_Csd1; TIGR01863
744872005384	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757
744872005385	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
744872005386	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752
744872005387	Predicted transcriptional regulator [Transcription]; Region: COG2378
744872005388	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
744872005389	CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641
744872005390	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872005391	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
744872005392	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
744872005393	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
744872005394	active site
744872005395	HIGH motif; other site
744872005396	dimer interface [polypeptide binding]; other site
744872005397	KMSKS motif; other site
744872005398	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
744872005399	putative active site [active]
744872005400	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i); Region: GH20_chitobiase-like; cd06563
744872005401	active site
744872005402	Cupin domain; Region: Cupin_2; cl09118
744872005403	EamA-like transporter family; Region: EamA; cl01037
744872005404	EamA-like transporter family; Region: EamA; cl01037
744872005405	SelR domain; Region: SelR; cl00369
744872005406	excinuclease ABC subunit B; Provisional; Region: PRK05298
744872005407	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
744872005408	ATP binding site [chemical binding]; other site
744872005409	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
744872005410	nucleotide binding region [chemical binding]; other site
744872005411	ATP-binding site [chemical binding]; other site
744872005412	Ultra-violet resistance protein B; Region: UvrB; pfam12344
744872005413	UvrB/uvrC motif; Region: UVR; pfam02151
744872005414	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
744872005415	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872005416	ATP binding site [chemical binding]; other site
744872005417	Mg2+ binding site [ion binding]; other site
744872005418	G-X-G motif; other site
744872005419	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
744872005420	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
744872005421	Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908
744872005422	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
744872005423	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
744872005424	homodimer interface [polypeptide binding]; other site
744872005425	substrate-cofactor binding pocket; other site
744872005426	pyridoxal 5'-phosphate binding site [chemical binding]; other site
744872005427	catalytic residue [active]
744872005428	Protein of unknown function (DUF1393); Region: DUF1393; cl01942
744872005429	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
744872005430	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
744872005431	ATP-dependent protease La; Region: lon; TIGR00763
744872005432	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
744872005433	Walker A motif; other site
744872005434	ATP binding site [chemical binding]; other site
744872005435	Walker B motif; other site
744872005436	arginine finger; other site
744872005437	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
744872005438	Cache domain; Region: Cache_1; pfam02743
744872005439	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
744872005440	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
744872005441	Histidine kinase; Region: HisKA_2; cl06527
744872005442	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872005443	ATP binding site [chemical binding]; other site
744872005444	Mg2+ binding site [ion binding]; other site
744872005445	G-X-G motif; other site
744872005446	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
744872005447	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
744872005448	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
744872005449	motif II; other site
744872005450	transcriptional activator FtrB; Provisional; Region: ftrB; PRK09392
744872005451	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
744872005452	ligand binding site [chemical binding]; other site
744872005453	flexible hinge region; other site
744872005454	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
744872005455	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
744872005456	ATP binding site [chemical binding]; other site
744872005457	putative Mg++ binding site [ion binding]; other site
744872005458	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
744872005459	nucleotide binding region [chemical binding]; other site
744872005460	ATP-binding site [chemical binding]; other site
744872005461	helicase 45; Provisional; Region: PTZ00424
744872005462	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif (...; Region: DEADc; cd00268
744872005463	ATP binding site [chemical binding]; other site
744872005464	Mg++ binding site [ion binding]; other site
744872005465	motif III; other site
744872005466	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
744872005467	nucleotide binding region [chemical binding]; other site
744872005468	ATP-binding site [chemical binding]; other site
744872005469	DbpA RNA binding domain; Region: DbpA; pfam03880
744872005470	Uncharacterised ACR, YkgG family COG1556; Region: DUF162; cl00674
744872005471	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565
744872005472	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
744872005473	phosphate binding site [ion binding]; other site
744872005474	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
744872005475	FliG C-terminal domain; Region: FliG_C; pfam01706
744872005476	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
744872005477	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
744872005478	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
744872005479	Peptidase M16C associated; Region: M16C_assoc; pfam08367
744872005480	Domain of unknown function (DUF3783); Region: DUF3783; pfam12646
744872005481	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
744872005482	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488
744872005483	ssDNA binding site; other site
744872005484	generic binding surface II; other site
744872005485	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
744872005486	ATP binding site [chemical binding]; other site
744872005487	putative Mg++ binding site [ion binding]; other site
744872005488	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
744872005489	nucleotide binding region [chemical binding]; other site
744872005490	ATP-binding site [chemical binding]; other site
744872005491	YGGT family; Region: YGGT; cl00508
744872005492	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872005493	active site
744872005494	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
744872005495	phosphorylation site [posttranslational modification]
744872005496	intermolecular recognition site; other site
744872005497	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872005498	active site
744872005499	phosphorylation site [posttranslational modification]
744872005500	intermolecular recognition site; other site
744872005501	dimerization interface [polypeptide binding]; other site
744872005502	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
744872005503	metal binding site [ion binding]; metal-binding site
744872005504	active site
744872005505	I-site; other site
744872005506	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
744872005507	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
744872005508	RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when...; Region: RhoGAP; cl02570
744872005509	catalytic residue [active]
744872005510	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
744872005511	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485
744872005512	generic binding surface II; other site
744872005513	generic binding surface I; other site
744872005514	Transcriptional regulators [Transcription]; Region: PurR; COG1609
744872005515	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
744872005516	DNA binding site [nucleotide binding]
744872005517	domain linker motif; other site
744872005518	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
744872005519	dimerization interface [polypeptide binding]; other site
744872005520	ligand binding site [chemical binding]; other site
744872005521	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
744872005522	pyridoxal 5'-phosphate binding site [chemical binding]; other site
744872005523	homodimer interface [polypeptide binding]; other site
744872005524	catalytic residue [active]
744872005525	Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632
744872005526	Ribosomal protein S21; Region: Ribosomal_S21; cl00529
744872005527	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
744872005528	Peptidase family M23; Region: Peptidase_M23; pfam01551
744872005529	DHH family; Region: DHH; pfam01368
744872005530	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
744872005531	DHHA1 domain; Region: DHHA1; pfam02272
744872005532	pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644
744872005533	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
744872005534	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
744872005535	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734
744872005536	Recombination protein O N terminal; Region: RecO_N; pfam11967
744872005537	Recombination protein O C terminal; Region: RecO_C; pfam02565
744872005538	N-acetylglutamate synthase; Validated; Region: PRK05279
744872005539	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
744872005540	nucleotide binding site [chemical binding]; other site
744872005541	substrate binding site [chemical binding]; other site
744872005542	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
744872005543	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562
744872005544	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
744872005545	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
744872005546	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
744872005547	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
744872005548	TSCPD domain; Region: TSCPD; cl14834
744872005549	TIGR03545 family protein; Region: TIGR03545
744872005550	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261
744872005551	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
744872005552	adenylate kinase; Reviewed; Region: adk; PRK00279
744872005553	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
744872005554	AMP-binding site [chemical binding]; other site
744872005555	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
744872005556	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
744872005557	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801
744872005558	FMN binding site [chemical binding]; other site
744872005559	active site
744872005560	catalytic residues [active]
744872005561	substrate binding site [chemical binding]; other site
744872005562	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
744872005563	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
744872005564	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
744872005565	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
744872005566	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
744872005567	E3 interaction surface; other site
744872005568	lipoyl attachment site [posttranslational modification]; other site
744872005569	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
744872005570	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
744872005571	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872005572	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872005573	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
744872005574	pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149
744872005575	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
744872005576	tetramer interface [polypeptide binding]; other site
744872005577	TPP-binding site [chemical binding]; other site
744872005578	heterodimer interface [polypeptide binding]; other site
744872005579	phosphorylation loop region [posttranslational modification]
744872005580	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
744872005581	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
744872005582	PYR/PP interface [polypeptide binding]; other site
744872005583	dimer interface [polypeptide binding]; other site
744872005584	TPP binding site [chemical binding]; other site
744872005585	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
744872005586	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
744872005587	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872005588	sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384
744872005589	NAD(P) binding site [chemical binding]; other site
744872005590	active site
744872005591	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
744872005592	N- and C-terminal domain interface [polypeptide binding]; other site
744872005593	active site
744872005594	MgATP binding site [chemical binding]; other site
744872005595	catalytic site [active]
744872005596	metal binding site [ion binding]; metal-binding site
744872005597	carbohydrate binding site [chemical binding]; other site
744872005598	L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238
744872005599	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
744872005600	putative NAD(P) binding site [chemical binding]; other site
744872005601	catalytic Zn binding site [ion binding]; other site
744872005602	HD supefamily hydrolase [General function prediction only]; Region: COG3294
744872005603	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
744872005604	active site
744872005605	Protein of unknown function DUF124; Region: DUF124; cl00884
744872005606	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
744872005607	Cache domain; Region: Cache_1; pfam02743
744872005608	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
744872005609	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
744872005610	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
744872005611	Transposase domain (DUF772); Region: DUF772; cl12084
744872005612	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
744872005613	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
744872005614	Outer membrane efflux protein; Region: OEP; pfam02321
744872005615	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
744872005616	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
744872005617	FtsX-like permease family; Region: FtsX; pfam02687
744872005618	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
744872005619	FtsX-like permease family; Region: FtsX; pfam02687
744872005620	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
744872005621	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
744872005622	Walker A/P-loop; other site
744872005623	ATP binding site [chemical binding]; other site
744872005624	Q-loop/lid; other site
744872005625	ABC transporter signature motif; other site
744872005626	Walker B; other site
744872005627	D-loop; other site
744872005628	H-loop/switch region; other site
744872005629	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
744872005630	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850
744872005631	carboxyltransferase (CT) interaction site; other site
744872005632	biotinylation site [posttranslational modification]; other site
744872005633	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
744872005634	dimer interface [polypeptide binding]; other site
744872005635	phosphorylation site [posttranslational modification]
744872005636	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872005637	ATP binding site [chemical binding]; other site
744872005638	Mg2+ binding site [ion binding]; other site
744872005639	G-X-G motif; other site
744872005640	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
744872005641	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872005642	active site
744872005643	phosphorylation site [posttranslational modification]
744872005644	intermolecular recognition site; other site
744872005645	dimerization interface [polypeptide binding]; other site
744872005646	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
744872005647	DNA binding site [nucleotide binding]
744872005648	Cache domain; Region: Cache_1; pfam02743
744872005649	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
744872005650	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
744872005651	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
744872005652	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
744872005653	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
744872005654	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
744872005655	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
744872005656	TM-ABC transporter signature motif; other site
744872005657	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
744872005658	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216
744872005659	Walker A/P-loop; other site
744872005660	ATP binding site [chemical binding]; other site
744872005661	Q-loop/lid; other site
744872005662	ABC transporter signature motif; other site
744872005663	Walker B; other site
744872005664	D-loop; other site
744872005665	H-loop/switch region; other site
744872005666	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215
744872005667	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
744872005668	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
744872005669	putative ligand binding site [chemical binding]; other site
744872005670	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
744872005671	putative ligand binding site [chemical binding]; other site
744872005672	Response regulator receiver domain; Region: Response_reg; pfam00072
744872005673	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872005674	active site
744872005675	phosphorylation site [posttranslational modification]
744872005676	intermolecular recognition site; other site
744872005677	dimerization interface [polypeptide binding]; other site
744872005678	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
744872005679	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
744872005680	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225
744872005681	dimerization interface [polypeptide binding]; other site
744872005682	Histidine kinase; Region: His_kinase; pfam06580
744872005683	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872005684	ATP binding site [chemical binding]; other site
744872005685	Mg2+ binding site [ion binding]; other site
744872005686	G-X-G motif; other site
744872005687	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
744872005688	ligand binding site [chemical binding]; other site
744872005689	Leucyl/phenylalanyl-tRNA protein transferase; Region: Leu_Phe_trans; cl01006
744872005690	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
744872005691	Clp amino terminal domain; Region: Clp_N; pfam02861
744872005692	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
744872005693	Walker A motif; other site
744872005694	ATP binding site [chemical binding]; other site
744872005695	Walker B motif; other site
744872005696	arginine finger; other site
744872005697	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
744872005698	Walker A motif; other site
744872005699	ATP binding site [chemical binding]; other site
744872005700	Walker B motif; other site
744872005701	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
744872005702	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933
744872005703	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
744872005704	putative active site [active]
744872005705	Methanothermobacter thermautotrophicus Mth212-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Mth212-like_AP-endo; cd09085
744872005706	active site
744872005707	phosphate binding site A [ion binding]; other site
744872005708	putative catalytic site [active]
744872005709	DNA binding site [nucleotide binding]
744872005710	metal binding site A [ion binding]; metal-binding site
744872005711	putative AP binding site [nucleotide binding]; other site
744872005712	putative metal binding site B [ion binding]; other site
744872005713	phosphate binding site B [ion binding]; other site
744872005714	Rhomboid family; Region: Rhomboid; cl11446
744872005715	Predicted transcriptional regulator [Transcription]; Region: COG4189
744872005716	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
744872005717	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412
744872005718	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
744872005719	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
744872005720	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
744872005721	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
744872005722	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
744872005723	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
744872005724	RNA binding site [nucleotide binding]; other site
744872005725	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
744872005726	RNA binding site [nucleotide binding]; other site
744872005727	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927
744872005728	RNA binding site [nucleotide binding]; other site
744872005729	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927
744872005730	RNA binding site [nucleotide binding]; other site
744872005731	GAF domain; Region: GAF; cl00853
744872005732	Domain of unknown function DUF20; Region: UPF0118; cl00465
744872005733	Predicted solute binding protein [General function prediction only]; Region: COG3889
744872005734	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
744872005735	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872005736	dimer interface [polypeptide binding]; other site
744872005737	conserved gate region; other site
744872005738	ABC-ATPase subunit interface; other site
744872005739	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872005740	dimer interface [polypeptide binding]; other site
744872005741	conserved gate region; other site
744872005742	putative PBP binding loops; other site
744872005743	ABC-ATPase subunit interface; other site
744872005744	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
744872005745	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
744872005746	Walker A/P-loop; other site
744872005747	ATP binding site [chemical binding]; other site
744872005748	Q-loop/lid; other site
744872005749	ABC transporter signature motif; other site
744872005750	Walker B; other site
744872005751	D-loop; other site
744872005752	H-loop/switch region; other site
744872005753	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
744872005754	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
744872005755	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
744872005756	Walker A/P-loop; other site
744872005757	ATP binding site [chemical binding]; other site
744872005758	Q-loop/lid; other site
744872005759	ABC transporter signature motif; other site
744872005760	Walker B; other site
744872005761	D-loop; other site
744872005762	H-loop/switch region; other site
744872005763	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
744872005764	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
744872005765	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
744872005766	dimer interface [polypeptide binding]; other site
744872005767	active site
744872005768	CoA binding pocket [chemical binding]; other site
744872005769	Acyl transferase domain; Region: Acyl_transf_1; cl08282
744872005770	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
744872005771	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
744872005772	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
744872005773	NAD(P) binding site [chemical binding]; other site
744872005774	homotetramer interface [polypeptide binding]; other site
744872005775	homodimer interface [polypeptide binding]; other site
744872005776	active site
744872005777	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
744872005778	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
744872005779	dimer interface [polypeptide binding]; other site
744872005780	active site
744872005781	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
744872005782	trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656
744872005783	NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242
744872005784	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872005785	Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055
744872005786	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
744872005787	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850
744872005788	carboxyltransferase (CT) interaction site; other site
744872005789	biotinylation site [posttranslational modification]; other site
744872005790	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
744872005791	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
744872005792	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
744872005793	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
744872005794	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513
744872005795	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513
744872005796	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
744872005797	putative active site [active]
744872005798	putative metal binding site [ion binding]; other site
744872005799	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
744872005800	Cation efflux family; Region: Cation_efflux; cl00316
744872005801	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
744872005802	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714
744872005803	glutaminase active site [active]
744872005804	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
744872005805	dimer interface [polypeptide binding]; other site
744872005806	active site
744872005807	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
744872005808	dimer interface [polypeptide binding]; other site
744872005809	active site
744872005810	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
744872005811	dimer interface [polypeptide binding]; other site
744872005812	ssDNA binding site [nucleotide binding]; other site
744872005813	tetramer (dimer of dimers) interface [polypeptide binding]; other site
744872005814	Peptidase family U32; Region: Peptidase_U32; cl03113
744872005815	MarC family integral membrane protein; Region: MarC; cl00919
744872005816	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
744872005817	catalytic residues [active]
744872005818	lipoate-protein ligase A; Provisional; Region: lplA; PRK03822
744872005819	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
744872005820	Predicted secreted protein (DUF2259); Region: DUF2259; cl02309
744872005821	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
744872005822	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872005823	binding surface
744872005824	TPR motif; other site
744872005825	E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies.  These domains are associated with different types of catalytic domains at  either the N-terminal or C-terminal end; Region: E_set; cl09101
744872005826	shikimate kinase; Reviewed; Region: aroK; PRK00131
744872005827	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464
744872005828	ADP binding site [chemical binding]; other site
744872005829	magnesium binding site [ion binding]; other site
744872005830	putative shikimate binding site; other site
744872005831	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872005832	active site
744872005833	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
744872005834	phosphorylation site [posttranslational modification]
744872005835	intermolecular recognition site; other site
744872005836	dimerization interface [polypeptide binding]; other site
744872005837	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
744872005838	putative active site [active]
744872005839	heme pocket [chemical binding]; other site
744872005840	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
744872005841	metal binding site [ion binding]; metal-binding site
744872005842	active site
744872005843	I-site; other site
744872005844	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
744872005845	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
744872005846	6-phosphofructokinase; Provisional; Region: PRK03202
744872005847	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204
744872005848	active site
744872005849	ADP/pyrophosphate binding site [chemical binding]; other site
744872005850	dimerization interface [polypeptide binding]; other site
744872005851	allosteric effector site; other site
744872005852	fructose-1,6-bisphosphate binding site; other site
744872005853	Uncharacterized conserved protein [Function unknown]; Region: COG1306
744872005854	alpha-glucosidase; Provisional; Region: PRK10426
744872005855	YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594
744872005856	putative active site [active]
744872005857	putative catalytic site [active]
744872005858	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
744872005859	putative transporter; Provisional; Region: PRK11462
744872005860	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of...; Region: L-fuc_L-ara-isomerases; cl00947
744872005861	trimer interface [polypeptide binding]; other site
744872005862	substrate binding site [chemical binding]; other site
744872005863	hexamer (dimer of trimers) interface [polypeptide binding]; other site
744872005864	Mn binding site [ion binding]; other site
744872005865	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872005866	dimer interface [polypeptide binding]; other site
744872005867	conserved gate region; other site
744872005868	ABC-ATPase subunit interface; other site
744872005869	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872005870	dimer interface [polypeptide binding]; other site
744872005871	conserved gate region; other site
744872005872	putative PBP binding loops; other site
744872005873	ABC-ATPase subunit interface; other site
744872005874	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
744872005875	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
744872005876	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
744872005877	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
744872005878	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
744872005879	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-...; Region: YgdL_like; cd00755
744872005880	putative ATP binding site [chemical binding]; other site
744872005881	putative substrate interface [chemical binding]; other site
744872005882	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483
744872005883	Protein of unknown function (DUF499); Region: DUF499; pfam04465
744872005884	Protein of unknown function (DUF3780); Region: DUF3780; pfam12635
744872005885	Predicted ATPase [General function prediction only]; Region: COG4637
744872005886	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872005887	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872005888	Walker B; other site
744872005889	D-loop; other site
744872005890	H-loop/switch region; other site
744872005891	Transposase domain (DUF772); Region: DUF772; cl12084
744872005892	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
744872005893	putative active site [active]
744872005894	catalytic site [active]
744872005895	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
744872005896	ATP binding site [chemical binding]; other site
744872005897	putative Mg++ binding site [ion binding]; other site
744872005898	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
744872005899	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
744872005900	nucleotide binding region [chemical binding]; other site
744872005901	ATP-binding site [chemical binding]; other site
744872005902	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
744872005903	non-specific DNA binding site [nucleotide binding]; other site
744872005904	salt bridge; other site
744872005905	sequence-specific DNA binding site [nucleotide binding]; other site
744872005906	Domain of unknown function (DUF955); Region: DUF955; cl01076
744872005907	FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
744872005908	putative active site [active]
744872005909	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
744872005910	TPP-binding site [chemical binding]; other site
744872005911	dimer interface [polypeptide binding]; other site
744872005912	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
744872005913	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
744872005914	PYR/PP interface [polypeptide binding]; other site
744872005915	dimer interface [polypeptide binding]; other site
744872005916	TPP binding site [chemical binding]; other site
744872005917	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
744872005918	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
744872005919	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
744872005920	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
744872005921	active site
744872005922	NAD binding site [chemical binding]; other site
744872005923	metal binding site [ion binding]; metal-binding site
744872005924	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
744872005925	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
744872005926	Rrf2 family protein; Region: rrf2_super; TIGR00738
744872005927	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
744872005928	cysteine synthases; Region: cysKM; TIGR01136
744872005929	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561
744872005930	dimer interface [polypeptide binding]; other site
744872005931	pyridoxal 5'-phosphate binding site [chemical binding]; other site
744872005932	catalytic residue [active]
744872005933	PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_3; cd03393
744872005934	active site
744872005935	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
744872005936	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
744872005937	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
744872005938	active site
744872005939	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
744872005940	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
744872005941	TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes.  It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes.  TrmE contains a GTPase...; Region: trmE; cd04164
744872005942	G1 box; other site
744872005943	GTP/Mg2+ binding site [chemical binding]; other site
744872005944	Switch I region; other site
744872005945	G2 box; other site
744872005946	Switch II region; other site
744872005947	G3 box; other site
744872005948	G4 box; other site
744872005949	G5 box; other site
744872005950	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
744872005951	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872005952	Flavin-dependent tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Cell cycle control, cell division, chromosome partitioning]; Region: GidA; COG0445
744872005953	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide...; Region: NrdH; cd02976
744872005954	catalytic residues [active]
744872005955	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
744872005956	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
744872005957	peptide binding site [polypeptide binding]; other site
744872005958	CarD-like/TRCF domain; Region: CarD_TRCF; cl00588
744872005959	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
744872005960	substrate binding site [chemical binding]; other site
744872005961	dimer interface [polypeptide binding]; other site
744872005962	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cd00554
744872005963	homotrimer interaction site [polypeptide binding]; other site
744872005964	zinc binding site [ion binding]; other site
744872005965	CDP-binding sites; other site
744872005966	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
744872005967	endonuclease III; Region: ENDO3c; smart00478
744872005968	minor groove reading motif; other site
744872005969	helix-hairpin-helix signature motif; other site
744872005970	substrate binding pocket [chemical binding]; other site
744872005971	active site
744872005972	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
744872005973	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
744872005974	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
744872005975	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
744872005976	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
744872005977	motif II; other site
744872005978	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
744872005979	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
744872005980	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
744872005981	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
744872005982	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
744872005983	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
744872005984	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729
744872005985	Transcriptional regulators [Transcription]; Region: PurR; COG1609
744872005986	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
744872005987	DNA binding site [nucleotide binding]
744872005988	domain linker motif; other site
744872005989	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
744872005990	trehalose synthase; Region: treS_nterm; TIGR02456
744872005991	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
744872005992	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
744872005993	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872005994	dimer interface [polypeptide binding]; other site
744872005995	conserved gate region; other site
744872005996	putative PBP binding loops; other site
744872005997	ABC-ATPase subunit interface; other site
744872005998	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
744872005999	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
744872006000	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
744872006001	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
744872006002	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
744872006003	Transposase, Mutator family; Region: Transposase_mut; pfam00872
744872006004	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
744872006005	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
744872006006	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
744872006007	GTPase RsgA; Reviewed; Region: PRK01889
744872006008	YjeQ/EngC.  YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854
744872006009	GTPase/OB domain interface [polypeptide binding]; other site
744872006010	GTPase/Zn-binding domain interface [polypeptide binding]; other site
744872006011	GTP/Mg2+ binding site [chemical binding]; other site
744872006012	G4 box; other site
744872006013	G5 box; other site
744872006014	G1 box; other site
744872006015	Switch I region; other site
744872006016	G2 box; other site
744872006017	G3 box; other site
744872006018	Switch II region; other site
744872006019	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
744872006020	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872006021	active site
744872006022	phosphorylation site [posttranslational modification]
744872006023	intermolecular recognition site; other site
744872006024	dimerization interface [polypeptide binding]; other site
744872006025	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
744872006026	DNA binding residues [nucleotide binding]
744872006027	dimerization interface [polypeptide binding]; other site
744872006028	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
744872006029	GAF domain; Region: GAF; cl00853
744872006030	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
744872006031	GAF domain; Region: GAF; cl00853
744872006032	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
744872006033	Histidine kinase; Region: HisKA_3; pfam07730
744872006034	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872006035	ATP binding site [chemical binding]; other site
744872006036	Mg2+ binding site [ion binding]; other site
744872006037	G-X-G motif; other site
744872006038	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
744872006039	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872006040	Walker A/P-loop; other site
744872006041	ATP binding site [chemical binding]; other site
744872006042	Q-loop/lid; other site
744872006043	ABC transporter signature motif; other site
744872006044	Walker B; other site
744872006045	D-loop; other site
744872006046	H-loop/switch region; other site
744872006047	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
744872006048	Protein of unknown function (DUF990); Region: DUF990; cl01496
744872006049	Protein of unknown function (DUF990); Region: DUF990; cl01496
744872006050	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
744872006051	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
744872006052	putative substrate translocation pore; other site
744872006053	Major Facilitator Superfamily; Region: MFS_1; pfam07690
744872006054	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
744872006055	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
744872006056	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
744872006057	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
744872006058	putative active site [active]
744872006059	heme pocket [chemical binding]; other site
744872006060	PAS fold; Region: PAS; pfam00989
744872006061	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
744872006062	putative active site [active]
744872006063	heme pocket [chemical binding]; other site
744872006064	PAS fold; Region: PAS_4; pfam08448
744872006065	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
744872006066	GAF domain; Region: GAF; cl00853
744872006067	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
744872006068	Zn2+ binding site [ion binding]; other site
744872006069	Mg2+ binding site [ion binding]; other site
744872006070	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
744872006071	PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D.  PotA has two domains with the N-terminal domain containing the ATPase activity and the residues...; Region: ABC_PotA_N; cd03300
744872006072	Walker A/P-loop; other site
744872006073	ATP binding site [chemical binding]; other site
744872006074	Q-loop/lid; other site
744872006075	ABC transporter signature motif; other site
744872006076	Walker B; other site
744872006077	D-loop; other site
744872006078	H-loop/switch region; other site
744872006079	TOBE domain; Region: TOBE_2; cl01440
744872006080	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
744872006081	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872006082	putative PBP binding loops; other site
744872006083	dimer interface [polypeptide binding]; other site
744872006084	ABC-ATPase subunit interface; other site
744872006085	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
744872006086	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872006087	dimer interface [polypeptide binding]; other site
744872006088	conserved gate region; other site
744872006089	putative PBP binding loops; other site
744872006090	ABC-ATPase subunit interface; other site
744872006091	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
744872006092	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
744872006093	yrdC domain; Region: Sua5_yciO_yrdC; cl00305
744872006094	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
744872006095	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
744872006096	transmembrane helices; other site
744872006097	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
744872006098	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872006099	active site
744872006100	phosphorylation site [posttranslational modification]
744872006101	intermolecular recognition site; other site
744872006102	dimerization interface [polypeptide binding]; other site
744872006103	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
744872006104	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
744872006105	Cache domain; Region: Cache_1; pfam02743
744872006106	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225
744872006107	dimerization interface [polypeptide binding]; other site
744872006108	Histidine kinase; Region: His_kinase; pfam06580
744872006109	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872006110	ATP binding site [chemical binding]; other site
744872006111	Mg2+ binding site [ion binding]; other site
744872006112	G-X-G motif; other site
744872006113	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310
744872006114	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
744872006115	putative ligand binding site [chemical binding]; other site
744872006116	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
744872006117	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216
744872006118	Walker A/P-loop; other site
744872006119	ATP binding site [chemical binding]; other site
744872006120	Q-loop/lid; other site
744872006121	ABC transporter signature motif; other site
744872006122	Walker B; other site
744872006123	D-loop; other site
744872006124	H-loop/switch region; other site
744872006125	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215
744872006126	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
744872006127	TM-ABC transporter signature motif; other site
744872006128	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
744872006129	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310
744872006130	putative ligand binding site [chemical binding]; other site
744872006131	Metal binding protein ZntC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018
744872006132	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
744872006133	putative metal binding residues [ion binding]; other site
744872006134	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
744872006135	ABC component of the metal-type transporters.  This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc.  The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235
744872006136	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550
744872006137	ABC-ATPase subunit  interface; other site
744872006138	dimer interface [polypeptide binding]; other site
744872006139	putative PBP binding regions; other site
744872006140	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
744872006141	metal binding site 2 [ion binding]; metal-binding site
744872006142	putative DNA binding helix; other site
744872006143	metal binding site 1 [ion binding]; metal-binding site
744872006144	dimer interface [polypeptide binding]; other site
744872006145	structural Zn2+ binding site [ion binding]; other site
744872006146	Sugar fermentation stimulation protein; Region: SfsA; cl00647
744872006147	GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441
744872006148	GIY-YIG motif/motif A; other site
744872006149	putative active site [active]
744872006150	putative metal binding site [ion binding]; other site
744872006151	EamA-like transporter family; Region: EamA; cl01037
744872006152	EamA-like transporter family; Region: EamA; cl01037
744872006153	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
744872006154	Phd_YefM; Region: PhdYeFM; cl09153
744872006155	Protein of unknown function (DUF434); Region: DUF434; cl04460
744872006156	Transcriptional regulator [Transcription]; Region: LysR; COG0583
744872006157	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
744872006158	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
744872006159	putative dimerization interface [polypeptide binding]; other site
744872006160	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
744872006161	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
744872006162	Major Facilitator Superfamily; Region: MFS_1; pfam07690
744872006163	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
744872006164	Ligand Binding Site [chemical binding]; other site
744872006165	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
744872006166	Ligand Binding Site [chemical binding]; other site
744872006167	Natural resistance-associated macrophage protein; Region: Nramp; cl00836
744872006168	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
744872006169	active site
744872006170	phosphorylation site [posttranslational modification]
744872006171	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
744872006172	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
744872006173	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
744872006174	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
744872006175	motif II; other site
744872006176	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
744872006177	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
744872006178	homotrimer interaction site [polypeptide binding]; other site
744872006179	putative active site [active]
744872006180	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
744872006181	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
744872006182	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
744872006183	Predicted membrane protein (DUF2154); Region: DUF2154; cl12089
744872006184	putative transposase; Provisional; Region: PRK09857
744872006185	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
744872006186	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
744872006187	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
744872006188	Transposase domain (DUF772); Region: DUF772; cl12084
744872006189	Survival protein SurE; Region: SurE; cl00448
744872006190	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
744872006191	putative transposase OrfB; Reviewed; Region: PHA02517
744872006192	Transposase; Region: HTH_Tnp_Tc3_2; pfam01498
744872006193	Integrase core domain; Region: rve; cl01316
744872006194	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
744872006195	Transposase domain (DUF772); Region: DUF772; cl12084
744872006196	glycogen synthase; Provisional; Region: PRK14098
744872006197	Protein of unknown function (DUF523); Region: DUF523; cl00733
744872006198	Protein of unknown function (DUF1722); Region: DUF1722; cl01284
744872006199	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883
744872006200	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913
744872006201	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872006202	Walker A/P-loop; other site
744872006203	ATP binding site [chemical binding]; other site
744872006204	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
744872006205	Cache domain; Region: Cache_1; pfam02743
744872006206	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
744872006207	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225
744872006208	dimerization interface [polypeptide binding]; other site
744872006209	Histidine kinase; Region: His_kinase; pfam06580
744872006210	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872006211	ATP binding site [chemical binding]; other site
744872006212	Mg2+ binding site [ion binding]; other site
744872006213	G-X-G motif; other site
744872006214	Response regulator receiver domain; Region: Response_reg; pfam00072
744872006215	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872006216	active site
744872006217	phosphorylation site [posttranslational modification]
744872006218	intermolecular recognition site; other site
744872006219	dimerization interface [polypeptide binding]; other site
744872006220	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
744872006221	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
744872006222	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
744872006223	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
744872006224	Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309
744872006225	putative ligand binding site [chemical binding]; other site
744872006226	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
744872006227	Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309
744872006228	putative ligand binding site [chemical binding]; other site
744872006229	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
744872006230	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872006231	Walker A/P-loop; other site
744872006232	ATP binding site [chemical binding]; other site
744872006233	Q-loop/lid; other site
744872006234	ABC transporter signature motif; other site
744872006235	Walker B; other site
744872006236	D-loop; other site
744872006237	H-loop/switch region; other site
744872006238	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215
744872006239	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
744872006240	TM-ABC transporter signature motif; other site
744872006241	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
744872006242	TM-ABC transporter signature motif; other site
744872006243	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
744872006244	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402
744872006245	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
744872006246	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
744872006247	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
744872006248	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872006249	dimer interface [polypeptide binding]; other site
744872006250	conserved gate region; other site
744872006251	putative PBP binding loops; other site
744872006252	ABC-ATPase subunit interface; other site
744872006253	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
744872006254	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872006255	dimer interface [polypeptide binding]; other site
744872006256	conserved gate region; other site
744872006257	putative PBP binding loops; other site
744872006258	ABC-ATPase subunit interface; other site
744872006259	Transcriptional regulators [Transcription]; Region: PurR; COG1609
744872006260	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
744872006261	DNA binding site [nucleotide binding]
744872006262	domain linker motif; other site
744872006263	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
744872006264	ligand binding site [chemical binding]; other site
744872006265	dimerization interface [polypeptide binding]; other site
744872006266	conserved hypothetical protein; Region: MJ1255; TIGR00661
744872006267	Glycosyl transferases group 1; Region: Glycos_transf_1; cl12012
744872006268	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032
744872006269	hypothetical protein; Reviewed; Region: PRK09588
744872006270	Transposase domain (DUF772); Region: DUF772; cl12084
744872006271	conserved hypothetical protein; Region: MJ1255; TIGR00661
744872006272	Histone deacetylase domain; Region: Hist_deacetyl; cl02986
744872006273	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
744872006274	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
744872006275	FtsX-like permease family; Region: FtsX; pfam02687
744872006276	LolC/E family; Region: lolCE; TIGR02212
744872006277	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
744872006278	FtsX-like permease family; Region: FtsX; pfam02687
744872006279	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
744872006280	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
744872006281	Walker A/P-loop; other site
744872006282	ATP binding site [chemical binding]; other site
744872006283	Q-loop/lid; other site
744872006284	ABC transporter signature motif; other site
744872006285	Walker B; other site
744872006286	D-loop; other site
744872006287	H-loop/switch region; other site
744872006288	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
744872006289	Predicted transcriptional regulators [Transcription]; Region: COG1725
744872006290	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
744872006291	DNA-binding site [nucleotide binding]; DNA binding site
744872006292	L-fucose isomerase; Provisional; Region: fucI; PRK10991
744872006293	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of...; Region: L-fuc_L-ara-isomerases; cl00947
744872006294	hexamer (dimer of trimers) interface [polypeptide binding]; other site
744872006295	trimer interface [polypeptide binding]; other site
744872006296	substrate binding site [chemical binding]; other site
744872006297	Mn binding site [ion binding]; other site
744872006298	Transcriptional regulators [Transcription]; Region: PurR; COG1609
744872006299	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
744872006300	DNA binding site [nucleotide binding]
744872006301	domain linker motif; other site
744872006302	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
744872006303	dimerization interface [polypeptide binding]; other site
744872006304	ligand binding site [chemical binding]; other site
744872006305	Membrane transport protein; Region: Mem_trans; cl09117
744872006306	RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809
744872006307	L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238
744872006308	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
744872006309	putative NAD(P) binding site [chemical binding]; other site
744872006310	catalytic Zn binding site [ion binding]; other site
744872006311	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
744872006312	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
744872006313	putative substrate binding site [chemical binding]; other site
744872006314	putative ATP binding site [chemical binding]; other site
744872006315	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
744872006316	dimerization domain swap beta strand [polypeptide binding]; other site
744872006317	regulatory protein interface [polypeptide binding]; other site
744872006318	active site
744872006319	regulatory phosphorylation site [posttranslational modification]; other site
744872006320	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
744872006321	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
744872006322	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
744872006323	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
744872006324	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
744872006325	active site
744872006326	phosphorylation site [posttranslational modification]
744872006327	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
744872006328	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
744872006329	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
744872006330	PRD domain; Region: PRD; pfam00874
744872006331	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
744872006332	P-loop; other site
744872006333	active site
744872006334	phosphorylation site [posttranslational modification]
744872006335	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
744872006336	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
744872006337	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557
744872006338	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_mannitol; cd05567
744872006339	active site
744872006340	P-loop; other site
744872006341	phosphorylation site [posttranslational modification]
744872006342	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
744872006343	putative hydrolase; Validated; Region: PRK09248
744872006344	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
744872006345	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
744872006346	MatE; Region: MatE; cl10513
744872006347	MatE; Region: MatE; cl10513
744872006348	pfkB family carbohydrate kinase; Region: PfkB; pfam00294
744872006349	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
744872006350	putative substrate binding site [chemical binding]; other site
744872006351	putative ATP binding site [chemical binding]; other site
744872006352	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
744872006353	active site clefts [active]
744872006354	zinc binding site [ion binding]; other site
744872006355	dimer interface [polypeptide binding]; other site
744872006356	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051
744872006357	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
744872006358	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
744872006359	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
744872006360	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
744872006361	dimerization interface [polypeptide binding]; other site
744872006362	putative DNA binding site [nucleotide binding]; other site
744872006363	putative Zn2+ binding site [ion binding]; other site
744872006364	Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; cl02047
744872006365	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
744872006366	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
744872006367	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
744872006368	putative acyl-acceptor binding pocket; other site
744872006369	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
744872006370	putative active site [active]
744872006371	putative CoA binding site [chemical binding]; other site
744872006372	nudix motif; other site
744872006373	metal binding site [ion binding]; metal-binding site
744872006374	Transposase domain (DUF772); Region: DUF772; cl12084
744872006375	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
744872006376	non-specific DNA binding site [nucleotide binding]; other site
744872006377	salt bridge; other site
744872006378	sequence-specific DNA binding site [nucleotide binding]; other site
744872006379	putative transporter; Provisional; Region: PRK11660
744872006380	Sulfate transporter family; Region: Sulfate_transp; cl00967
744872006381	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
744872006382	FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
744872006383	putative active site [active]
744872006384	Phd_YefM; Region: PhdYeFM; cl09153
744872006385	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
744872006386	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
744872006387	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872006388	Walker A/P-loop; other site
744872006389	ATP binding site [chemical binding]; other site
744872006390	Q-loop/lid; other site
744872006391	ABC transporter signature motif; other site
744872006392	Walker B; other site
744872006393	D-loop; other site
744872006394	H-loop/switch region; other site
744872006395	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
744872006396	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
744872006397	catalytic tetrad [active]
744872006398	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
744872006399	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412
744872006400	Histidine kinase; Region: HisKA_3; pfam07730
744872006401	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
744872006402	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
744872006403	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872006404	active site
744872006405	phosphorylation site [posttranslational modification]
744872006406	intermolecular recognition site; other site
744872006407	dimerization interface [polypeptide binding]; other site
744872006408	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
744872006409	DNA binding residues [nucleotide binding]
744872006410	dimerization interface [polypeptide binding]; other site
744872006411	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
744872006412	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
744872006413	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
744872006414	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872006415	dimer interface [polypeptide binding]; other site
744872006416	conserved gate region; other site
744872006417	putative PBP binding loops; other site
744872006418	ABC-ATPase subunit interface; other site
744872006419	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
744872006420	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872006421	dimer interface [polypeptide binding]; other site
744872006422	conserved gate region; other site
744872006423	putative PBP binding loops; other site
744872006424	ABC-ATPase subunit interface; other site
744872006425	DRTGG domain; Region: DRTGG; cl12147
744872006426	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360
744872006427	Phd_YefM; Region: PhdYeFM; cl09153
744872006428	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
744872006429	dimer interface [polypeptide binding]; other site
744872006430	catalytic triad [active]
744872006431	peroxidatic and resolving cysteines [active]
744872006432	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
744872006433	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259
744872006434	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
744872006435	Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990
744872006436	substrate binding site [chemical binding]; other site
744872006437	active site
744872006438	Glycosyl hydrolases family 43; Region: Glyco_hydro_43; pfam04616
744872006439	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
744872006440	ligand binding site [chemical binding]; other site
744872006441	Carboxylesterase family; Region: COesterase; pfam00135
744872006442	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
744872006443	substrate binding pocket [chemical binding]; other site
744872006444	catalytic triad [active]
744872006445	lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462
744872006446	lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462
744872006447	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
744872006448	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
744872006449	Protein of unknown function DUF86; Region: DUF86; cl01031
744872006450	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
744872006451	active site
744872006452	NTP binding site [chemical binding]; other site
744872006453	metal binding triad [ion binding]; metal-binding site
744872006454	antibiotic binding site [chemical binding]; other site
744872006455	Alpha-kinase family; Region: Alpha_kinase; cl03728
744872006456	Major Facilitator Superfamily; Region: MFS_1; pfam07690
744872006457	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
744872006458	CobD/Cbib protein; Region: CobD_Cbib; cl00561
744872006459	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
744872006460	Tetramer interface [polypeptide binding]; other site
744872006461	Active site [active]
744872006462	FMN-binding site [chemical binding]; other site
744872006463	MoxR-like ATPases [General function prediction only]; Region: COG0714
744872006464	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
744872006465	Walker A motif; other site
744872006466	ATP binding site [chemical binding]; other site
744872006467	Walker B motif; other site
744872006468	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872006469	arginine finger; other site
744872006470	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
744872006471	Protein of unknown function DUF58; Region: DUF58; pfam01882
744872006472	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
744872006473	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
744872006474	Protein of unknown function DUF58; Region: DUF58; pfam01882
744872006475	MoxR-like ATPases [General function prediction only]; Region: COG0714
744872006476	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
744872006477	Walker A motif; other site
744872006478	ATP binding site [chemical binding]; other site
744872006479	Walker B motif; other site
744872006480	arginine finger; other site
744872006481	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
744872006482	TM-ABC transporter signature motif; other site
744872006483	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
744872006484	TM-ABC transporter signature motif; other site
744872006485	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
744872006486	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216
744872006487	Walker A/P-loop; other site
744872006488	ATP binding site [chemical binding]; other site
744872006489	Q-loop/lid; other site
744872006490	ABC transporter signature motif; other site
744872006491	Walker B; other site
744872006492	D-loop; other site
744872006493	H-loop/switch region; other site
744872006494	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215
744872006495	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
744872006496	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
744872006497	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
744872006498	Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309
744872006499	putative ligand binding site [chemical binding]; other site
744872006500	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
744872006501	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225
744872006502	dimerization interface [polypeptide binding]; other site
744872006503	Histidine kinase; Region: His_kinase; pfam06580
744872006504	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872006505	ATP binding site [chemical binding]; other site
744872006506	Mg2+ binding site [ion binding]; other site
744872006507	G-X-G motif; other site
744872006508	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
744872006509	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872006510	active site
744872006511	phosphorylation site [posttranslational modification]
744872006512	intermolecular recognition site; other site
744872006513	dimerization interface [polypeptide binding]; other site
744872006514	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
744872006515	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
744872006516	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
744872006517	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
744872006518	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
744872006519	non-specific DNA binding site [nucleotide binding]; other site
744872006520	salt bridge; other site
744872006521	sequence-specific DNA binding site [nucleotide binding]; other site
744872006522	Cupin domain; Region: Cupin_2; cl09118
744872006523	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
744872006524	tetramer (dimer of dimers) interface [polypeptide binding]; other site
744872006525	active site
744872006526	dimer interface [polypeptide binding]; other site
744872006527	PAS fold; Region: PAS_4; pfam08448
744872006528	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
744872006529	putative active site [active]
744872006530	heme pocket [chemical binding]; other site
744872006531	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
744872006532	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
744872006533	bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase; Region: PLN02520
744872006534	active site
744872006535	catalytic residue [active]
744872006536	dimer interface [polypeptide binding]; other site
744872006537	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
744872006538	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
744872006539	shikimate binding site; other site
744872006540	NAD(P) binding site [chemical binding]; other site
744872006541	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
744872006542	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
744872006543	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
744872006544	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
744872006545	active site
744872006546	nucleotide binding site [chemical binding]; other site
744872006547	HIGH motif; other site
744872006548	KMSKS motif; other site
744872006549	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
744872006550	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577
744872006551	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577
744872006552	Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223
744872006553	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
744872006554	putative active site [active]
744872006555	substrate binding site [chemical binding]; other site
744872006556	putative cosubstrate binding site; other site
744872006557	catalytic site [active]
744872006558	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
744872006559	substrate binding site [chemical binding]; other site
744872006560	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487
744872006561	active site
744872006562	catalytic residues [active]
744872006563	metal binding site [ion binding]; metal-binding site
744872006564	penicillin-binding protein 1C; Region: PBP_1c; TIGR02073
744872006565	Transglycosylase; Region: Transgly; cl07896
744872006566	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
744872006567	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
744872006568	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
744872006569	MG2 domain; Region: A2M_N; pfam01835
744872006570	Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703
744872006571	Alpha-2-macroglobulin family; Region: A2M; pfam00207
744872006572	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
744872006573	surface patch; other site
744872006574	thioester region; other site
744872006575	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
744872006576	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
744872006577	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
744872006578	metal binding site [ion binding]; metal-binding site
744872006579	active site
744872006580	I-site; other site
744872006581	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
744872006582	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872006583	active site
744872006584	phosphorylation site [posttranslational modification]
744872006585	intermolecular recognition site; other site
744872006586	dimerization interface [polypeptide binding]; other site
744872006587	CheB methylesterase; Region: CheB_methylest; pfam01339
744872006588	CheD chemotactic sensory transduction; Region: CheD; cl00810
744872006589	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
744872006590	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
744872006591	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
744872006592	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729
744872006593	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
744872006594	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
744872006595	putative CheA interaction surface; other site
744872006596	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
744872006597	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872006598	active site
744872006599	phosphorylation site [posttranslational modification]
744872006600	intermolecular recognition site; other site
744872006601	dimerization interface [polypeptide binding]; other site
744872006602	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
744872006603	putative binding surface; other site
744872006604	active site
744872006605	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489
744872006606	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
744872006607	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872006608	ATP binding site [chemical binding]; other site
744872006609	Mg2+ binding site [ion binding]; other site
744872006610	G-X-G motif; other site
744872006611	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
744872006612	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
744872006613	Response regulator receiver domain; Region: Response_reg; pfam00072
744872006614	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872006615	active site
744872006616	phosphorylation site [posttranslational modification]
744872006617	intermolecular recognition site; other site
744872006618	dimerization interface [polypeptide binding]; other site
744872006619	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
744872006620	L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239
744872006621	putative NAD(P) binding site [chemical binding]; other site
744872006622	catalytic Zn binding site [ion binding]; other site
744872006623	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
744872006624	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
744872006625	active site
744872006626	catalytic tetrad [active]
744872006627	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
744872006628	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
744872006629	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
744872006630	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872006631	ATPase domain of DNA mismatch repair MUTS family; Region: MUTSac; smart00534
744872006632	Walker A/P-loop; other site
744872006633	ATP binding site [chemical binding]; other site
744872006634	Q-loop/lid; other site
744872006635	ABC transporter signature motif; other site
744872006636	Walker B; other site
744872006637	D-loop; other site
744872006638	H-loop/switch region; other site
744872006639	Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249
744872006640	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872006641	Walker A/P-loop; other site
744872006642	ATP binding site [chemical binding]; other site
744872006643	Q-loop/lid; other site
744872006644	ABC transporter signature motif; other site
744872006645	Walker B; other site
744872006646	D-loop; other site
744872006647	H-loop/switch region; other site
744872006648	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872006649	TPR motif; other site
744872006650	binding surface
744872006651	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528
744872006652	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
744872006653	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
744872006654	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848
744872006655	lipoyl attachment site [posttranslational modification]; other site
744872006656	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
744872006657	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613
744872006658	tetramer interface [polypeptide binding]; other site
744872006659	pyridoxal 5'-phosphate binding site [chemical binding]; other site
744872006660	catalytic residue [active]
744872006661	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
744872006662	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
744872006663	catalytic residue [active]
744872006664	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
744872006665	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270
744872006666	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
744872006667	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
744872006668	DNA binding site [nucleotide binding]
744872006669	active site
744872006670	Flagellar hook capping protein; Region: FlgD; cl04347
744872006671	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
744872006672	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
744872006673	ligand binding site [chemical binding]; other site
744872006674	tellurite resistance protein TehB; Provisional; Region: PRK12335
744872006675	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
744872006676	S-adenosylmethionine binding site [chemical binding]; other site
744872006677	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
744872006678	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
744872006679	Substrate binding site [chemical binding]; other site
744872006680	Acetokinase family; Region: Acetate_kinase; cl01029
744872006681	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192
744872006682	pfkB family carbohydrate kinase; Region: PfkB; pfam00294
744872006683	substrate binding site [chemical binding]; other site
744872006684	ATP binding site [chemical binding]; other site
744872006685	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
744872006686	conserved cys residue [active]
744872006687	Response regulator receiver domain; Region: Response_reg; pfam00072
744872006688	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872006689	active site
744872006690	phosphorylation site [posttranslational modification]
744872006691	intermolecular recognition site; other site
744872006692	dimerization interface [polypeptide binding]; other site
744872006693	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872006694	Response regulator receiver domain; Region: Response_reg; pfam00072
744872006695	active site
744872006696	phosphorylation site [posttranslational modification]
744872006697	intermolecular recognition site; other site
744872006698	dimerization interface [polypeptide binding]; other site
744872006699	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
744872006700	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
744872006701	dimer interface [polypeptide binding]; other site
744872006702	phosphorylation site [posttranslational modification]
744872006703	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872006704	ATP binding site [chemical binding]; other site
744872006705	Mg2+ binding site [ion binding]; other site
744872006706	G-X-G motif; other site
744872006707	Response regulator receiver domain; Region: Response_reg; pfam00072
744872006708	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872006709	active site
744872006710	phosphorylation site [posttranslational modification]
744872006711	intermolecular recognition site; other site
744872006712	dimerization interface [polypeptide binding]; other site
744872006713	Response regulator receiver domain; Region: Response_reg; pfam00072
744872006714	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872006715	active site
744872006716	phosphorylation site [posttranslational modification]
744872006717	intermolecular recognition site; other site
744872006718	dimerization interface [polypeptide binding]; other site
744872006719	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
744872006720	putative binding surface; other site
744872006721	active site
744872006722	histidinol-phosphatase; Provisional; Region: PRK07328
744872006723	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
744872006724	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
744872006725	rRNA binding site [nucleotide binding]; other site
744872006726	predicted 30S ribosome binding site; other site
744872006727	Smr domain; Region: Smr; cl02619
744872006728	potential frameshift: common BLAST hit: gi|328947151|ref|YP_004364488.1| von Willebrand factor type A
744872006729	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429
744872006730	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
744872006731	metal ion-dependent adhesion site (MIDAS); other site
744872006732	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
744872006733	metal ion-dependent adhesion site (MIDAS); other site
744872006734	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
744872006735	Protein of unknown function DUF58; Region: DUF58; pfam01882
744872006736	MoxR-like ATPases [General function prediction only]; Region: COG0714
744872006737	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872006738	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872006739	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872006740	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
744872006741	pyridoxal 5'-phosphate binding site [chemical binding]; other site
744872006742	homodimer interface [polypeptide binding]; other site
744872006743	catalytic residue [active]
744872006744	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
744872006745	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
744872006746	Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821
744872006747	active site
744872006748	substrate-binding site [chemical binding]; other site
744872006749	metal-binding site [ion binding]
744872006750	GTP binding site [chemical binding]; other site
744872006751	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
744872006752	ligand binding site [chemical binding]; other site
744872006753	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
744872006754	GTP-binding protein YchF; Reviewed; Region: PRK09601
744872006755	YchF subfamily.  YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1.  Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900
744872006756	G1 box; other site
744872006757	GTP/Mg2+ binding site [chemical binding]; other site
744872006758	Switch I region; other site
744872006759	G2 box; other site
744872006760	Switch II region; other site
744872006761	G3 box; other site
744872006762	G4 box; other site
744872006763	G5 box; other site
744872006764	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
744872006765	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
744872006766	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
744872006767	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557
744872006768	homodimer interface [polypeptide binding]; other site
744872006769	substrate-cofactor binding pocket; other site
744872006770	catalytic residue [active]
744872006771	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
744872006772	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
744872006773	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
744872006774	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
744872006775	active site
744872006776	dimer interface [polypeptide binding]; other site
744872006777	motif 1; other site
744872006778	motif 2; other site
744872006779	motif 3; other site
744872006780	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
744872006781	anticodon binding site; other site
744872006782	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
744872006783	Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691
744872006784	YcfA-like protein; Region: YcfA; cl00752
744872006785	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
744872006786	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal...; Region: PurM-like; cl10019
744872006787	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203
744872006788	dimerization interface [polypeptide binding]; other site
744872006789	ATP binding site [chemical binding]; other site
744872006790	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal...; Region: PurM-like; cl10019
744872006791	dimerization interface [polypeptide binding]; other site
744872006792	ATP binding site [chemical binding]; other site
744872006793	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
744872006794	putative active site [active]
744872006795	catalytic triad [active]
744872006796	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
744872006797	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
744872006798	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
744872006799	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
744872006800	NAD synthetase; Provisional; Region: PRK13981
744872006801	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
744872006802	multimer interface [polypeptide binding]; other site
744872006803	active site
744872006804	catalytic triad [active]
744872006805	protein interface 1 [polypeptide binding]; other site
744872006806	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553
744872006807	homodimer interface [polypeptide binding]; other site
744872006808	NAD binding pocket [chemical binding]; other site
744872006809	ATP binding pocket [chemical binding]; other site
744872006810	Mg binding site [ion binding]; other site
744872006811	active-site loop [active]
744872006812	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
744872006813	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
744872006814	putative active site [active]
744872006815	putative metal binding site [ion binding]; other site
744872006816	transcriptional regulator PpsR; Region: PpsR-CrtJ; TIGR02040
744872006817	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
744872006818	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
744872006819	putative active site [active]
744872006820	heme pocket [chemical binding]; other site
744872006821	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
744872006822	dimer interface [polypeptide binding]; other site
744872006823	phosphorylation site [posttranslational modification]
744872006824	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872006825	ATP binding site [chemical binding]; other site
744872006826	Mg2+ binding site [ion binding]; other site
744872006827	G-X-G motif; other site
744872006828	Response regulator receiver domain; Region: Response_reg; pfam00072
744872006829	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872006830	active site
744872006831	phosphorylation site [posttranslational modification]
744872006832	intermolecular recognition site; other site
744872006833	dimerization interface [polypeptide binding]; other site
744872006834	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
744872006835	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
744872006836	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
744872006837	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
744872006838	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin...; Region: S1_Tex; cd05685
744872006839	RNA binding site [nucleotide binding]; other site
744872006840	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
744872006841	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
744872006842	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
744872006843	hydrogenase, Fe-only; Region: Fe_only_hydrog; TIGR02512
744872006844	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
744872006845	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
744872006846	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
744872006847	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408
744872006848	Cache domain; Region: Cache_2; cl07034
744872006849	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
744872006850	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
744872006851	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
744872006852	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
744872006853	ATP binding site [chemical binding]; other site
744872006854	active site
744872006855	substrate binding site [chemical binding]; other site
744872006856	amidophosphoribosyltransferase; Provisional; Region: PRK05793
744872006857	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
744872006858	active site
744872006859	tetramer interface [polypeptide binding]; other site
744872006860	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
744872006861	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
744872006862	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
744872006863	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196
744872006864	dimerization interface [polypeptide binding]; other site
744872006865	putative ATP binding site [chemical binding]; other site
744872006866	phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent; Region: PurN; TIGR00639
744872006867	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
744872006868	active site
744872006869	substrate binding site [chemical binding]; other site
744872006870	cosubstrate binding site; other site
744872006871	catalytic site [active]
744872006872	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421
744872006873	purine monophosphate binding site [chemical binding]; other site
744872006874	dimer interface [polypeptide binding]; other site
744872006875	putative catalytic residues [active]
744872006876	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
744872006877	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
744872006878	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
744872006879	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
744872006880	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
744872006881	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
744872006882	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
744872006883	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
744872006884	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
744872006885	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
744872006886	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872006887	dimer interface [polypeptide binding]; other site
744872006888	ABC-ATPase subunit interface; other site
744872006889	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
744872006890	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
744872006891	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
744872006892	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
744872006893	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
744872006894	MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251
744872006895	Walker A/P-loop; other site
744872006896	ATP binding site [chemical binding]; other site
744872006897	Q-loop/lid; other site
744872006898	ABC transporter signature motif; other site
744872006899	Walker B; other site
744872006900	D-loop; other site
744872006901	H-loop/switch region; other site
744872006902	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
744872006903	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
744872006904	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872006905	Walker A/P-loop; other site
744872006906	ATP binding site [chemical binding]; other site
744872006907	Q-loop/lid; other site
744872006908	ABC transporter signature motif; other site
744872006909	Walker B; other site
744872006910	D-loop; other site
744872006911	H-loop/switch region; other site
744872006912	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
744872006913	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
744872006914	Histidine kinase; Region: HisKA_2; cl06527
744872006915	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872006916	ATP binding site [chemical binding]; other site
744872006917	Mg2+ binding site [ion binding]; other site
744872006918	G-X-G motif; other site
744872006919	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
744872006920	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
744872006921	ligand binding site [chemical binding]; other site
744872006922	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
744872006923	AMP-binding domain protein; Validated; Region: PRK08315
744872006924	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
744872006925	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
744872006926	non-specific DNA binding site [nucleotide binding]; other site
744872006927	salt bridge; other site
744872006928	sequence-specific DNA binding site [nucleotide binding]; other site
744872006929	Cupin domain; Region: Cupin_2; cl09118
744872006930	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
744872006931	Surface antigen; Region: Bac_surface_Ag; cl03097
744872006932	FMN-binding domain; Region: FMN_bind; cl01081
744872006933	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
744872006934	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872006935	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
744872006936	ATP phosphoribosyltransferase; Region: HisG; cl15266
744872006937	HisG, C-terminal domain; Region: HisG_C; cl06867
744872006938	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
744872006939	putative active site pocket [active]
744872006940	4-fold oligomerization interface [polypeptide binding]; other site
744872006941	metal binding residues [ion binding]; metal-binding site
744872006942	3-fold/trimer interface [polypeptide binding]; other site
744872006943	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
744872006944	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
744872006945	putative active site [active]
744872006946	oxyanion strand; other site
744872006947	catalytic triad [active]
744872006948	Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107
744872006949	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731
744872006950	substrate binding site [chemical binding]; other site
744872006951	glutamase interaction surface [polypeptide binding]; other site
744872006952	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732
744872006953	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
744872006954	catalytic residues [active]
744872006955	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
744872006956	Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344
744872006957	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
744872006958	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
744872006959	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
744872006960	pyridoxal 5'-phosphate binding site [chemical binding]; other site
744872006961	homodimer interface [polypeptide binding]; other site
744872006962	catalytic residue [active]
744872006963	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
744872006964	E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572
744872006965	NAD binding site [chemical binding]; other site
744872006966	dimerization interface [polypeptide binding]; other site
744872006967	product binding site; other site
744872006968	substrate binding site [chemical binding]; other site
744872006969	zinc binding site [ion binding]; other site
744872006970	catalytic residues [active]
744872006971	Integrase core domain; Region: rve; cl01316
744872006972	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl14895
744872006973	Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731
744872006974	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259
744872006975	Transposase domain (DUF772); Region: DUF772; cl12084
744872006976	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872006977	TPR motif; other site
744872006978	binding surface
744872006979	Protein of unknown function (DUF3808); Region: DUF3808; pfam10300
744872006980	Transposase domain (DUF772); Region: DUF772; cl12084
744872006981	Cupin domain; Region: Cupin_2; cl09118
744872006982	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
744872006983	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
744872006984	MatE; Region: MatE; cl10513
744872006985	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
744872006986	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872006987	dimer interface [polypeptide binding]; other site
744872006988	conserved gate region; other site
744872006989	ABC-ATPase subunit interface; other site
744872006990	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
744872006991	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872006992	dimer interface [polypeptide binding]; other site
744872006993	conserved gate region; other site
744872006994	putative PBP binding loops; other site
744872006995	ABC-ATPase subunit interface; other site
744872006996	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
744872006997	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
744872006998	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001
744872006999	Glycosyl hydrolases family 43; Region: Glyco_hydro_43; pfam04616
744872007000	active site
744872007001	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
744872007002	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
744872007003	inhibitor binding site; inhibition site
744872007004	active site
744872007005	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
744872007006	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
744872007007	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
744872007008	Transposase; Region: DDE_Tnp_ISL3; pfam01610
744872007009	cyclase homology domain; Region: CHD; cd07302
744872007010	nucleotidyl binding site; other site
744872007011	metal binding site [ion binding]; metal-binding site
744872007012	dimer interface [polypeptide binding]; other site
744872007013	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
744872007014	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
744872007015	AIR carboxylase; Region: AIRC; cl00310
744872007016	Peptidase family M48; Region: Peptidase_M48; cl12018
744872007017	Helix-turn-helix domain; Region: HTH_18; pfam12833
744872007018	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
744872007019	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
744872007020	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
744872007021	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
744872007022	CoA enzyme activase uncharacterised domain (DUF2229); Region: DUF2229; cl12083
744872007023	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
744872007024	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
744872007025	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
744872007026	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
744872007027	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
744872007028	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
744872007029	N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221
744872007030	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
744872007031	active site
744872007032	dimer interface [polypeptide binding]; other site
744872007033	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination...; Region: GlcN6P_deaminase; cd01399
744872007034	active site
744872007035	trimer interface [polypeptide binding]; other site
744872007036	allosteric site; other site
744872007037	active site lid [active]
744872007038	hexamer (dimer of trimers) interface [polypeptide binding]; other site
744872007039	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
744872007040	MgtE intracellular N domain; Region: MgtE_N; cl15244
744872007041	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
744872007042	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141
744872007043	Divalent cation transporter; Region: MgtE; cl00786
744872007044	CrcB-like protein; Region: CRCB; cl09114
744872007045	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
744872007046	OsmC-like protein; Region: OsmC; cl00767
744872007047	outer membrane lipoprotein; Provisional; Region: spr; PRK10838
744872007048	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
744872007049	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
744872007050	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
744872007051	dimer interface [polypeptide binding]; other site
744872007052	PYR/PP interface [polypeptide binding]; other site
744872007053	TPP binding site [chemical binding]; other site
744872007054	substrate binding site [chemical binding]; other site
744872007055	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
744872007056	Domain of unknown function; Region: EKR; cl11037
744872007057	4Fe-4S binding domain; Region: Fer4; cl02805
744872007058	4Fe-4S binding domain; Region: Fer4; cl02805
744872007059	TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This subfamily also includes proteins characterized as...; Region: TPP_PFOR_PNO; cd03377
744872007060	TPP-binding site [chemical binding]; other site
744872007061	dimer interface [polypeptide binding]; other site
744872007062	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
744872007063	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872007064	active site
744872007065	phosphorylation site [posttranslational modification]
744872007066	intermolecular recognition site; other site
744872007067	dimerization interface [polypeptide binding]; other site
744872007068	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
744872007069	Walker A motif; other site
744872007070	ATP binding site [chemical binding]; other site
744872007071	Walker B motif; other site
744872007072	arginine finger; other site
744872007073	Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
744872007074	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
744872007075	glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047
744872007076	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
744872007077	GntP family permease; Region: GntP_permease; cl15264
744872007078	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
744872007079	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
744872007080	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
744872007081	putative active site [active]
744872007082	catalytic residue [active]
744872007083	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402
744872007084	catalytic site [active]
744872007085	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869
744872007086	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141
744872007087	DRTGG domain; Region: DRTGG; cl12147
744872007088	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
744872007089	DHH family; Region: DHH; pfam01368
744872007090	DHHA2 domain; Region: DHHA2; pfam02833
744872007091	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556
744872007092	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
744872007093	oligomer interface [polypeptide binding]; other site
744872007094	active site residues [active]
744872007095	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
744872007096	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872007097	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
744872007098	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
744872007099	active site residue [active]
744872007100	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
744872007101	active site residue [active]
744872007102	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872007103	binding surface
744872007104	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
744872007105	TPR motif; other site
744872007106	Formate--tetrahydrofolate ligase; Region: FTHFS; pfam01268
744872007107	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
744872007108	Potassium binding sites [ion binding]; other site
744872007109	Cesium cation binding sites [ion binding]; other site
744872007110	alanine racemase; Reviewed; Region: alr; PRK00053
744872007111	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
744872007112	active site
744872007113	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
744872007114	dimer interface [polypeptide binding]; other site
744872007115	substrate binding site [chemical binding]; other site
744872007116	catalytic residues [active]
744872007117	Nickel uptake substrate-specific transmembrane region; Region: NikM; pfam10670
744872007118	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
744872007119	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262
744872007120	Walker A/P-loop; other site
744872007121	ATP binding site [chemical binding]; other site
744872007122	Q-loop/lid; other site
744872007123	ABC transporter signature motif; other site
744872007124	Walker B; other site
744872007125	D-loop; other site
744872007126	H-loop/switch region; other site
744872007127	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
744872007128	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872007129	dimer interface [polypeptide binding]; other site
744872007130	conserved gate region; other site
744872007131	ABC-ATPase subunit interface; other site
744872007132	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
744872007133	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
744872007134	substrate binding pocket [chemical binding]; other site
744872007135	membrane-bound complex binding site; other site
744872007136	hinge residues; other site
744872007137	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
744872007138	metal ion-dependent adhesion site (MIDAS); other site
744872007139	Curli production assembly/transport component CsgG; Region: CsgG; cl00639
744872007140	Flagellin N-methylase; Region: FliB; cl00497
744872007141	Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139
744872007142	putative FMN binding site [chemical binding]; other site
744872007143	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
744872007144	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
744872007145	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
744872007146	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
744872007147	integral membrane protein MviN; Region: mviN; TIGR01695
744872007148	MatE; Region: MatE; cl10513
744872007149	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
744872007150	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
744872007151	active site
744872007152	catalytic site [active]
744872007153	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
744872007154	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556
744872007155	hinge; other site
744872007156	active site
744872007157	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
744872007158	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872007159	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
744872007160	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872007161	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
744872007162	Cation transport protein; Region: TrkH; cl10514
744872007163	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
744872007164	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
744872007165	catalytic core domain of  class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674
744872007166	active site
744872007167	HIGH motif; other site
744872007168	KMSKS motif; other site
744872007169	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
744872007170	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
744872007171	metal-binding site [ion binding]
744872007172	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
744872007173	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
744872007174	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
744872007175	metal-binding site [ion binding]
744872007176	Omptin family; Region: Omptin; cl01886
744872007177	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
744872007178	ligand binding site [chemical binding]; other site
744872007179	flexible hinge region; other site
744872007180	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
744872007181	metal binding site [ion binding]; metal-binding site
744872007182	active site
744872007183	I-site; other site
744872007184	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
744872007185	ligand binding site [chemical binding]; other site
744872007186	flexible hinge region; other site
744872007187	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
744872007188	metal binding site [ion binding]; metal-binding site
744872007189	active site
744872007190	I-site; other site
744872007191	Transposase domain (DUF772); Region: DUF772; cl12084
744872007192	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
744872007193	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
744872007194	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
744872007195	Membrane transport protein; Region: Mem_trans; cl09117
744872007196	Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099
744872007197	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
744872007198	NAD(P) binding site [chemical binding]; other site
744872007199	catalytic residues [active]
744872007200	Sulfate transporter family; Region: Sulfate_transp; cl00967
744872007201	Permease family; Region: Xan_ur_permease; pfam00860
744872007202	Response regulator receiver domain; Region: Response_reg; pfam00072
744872007203	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872007204	active site
744872007205	phosphorylation site [posttranslational modification]
744872007206	intermolecular recognition site; other site
744872007207	dimerization interface [polypeptide binding]; other site
744872007208	Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406
744872007209	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
744872007210	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872007211	ATP binding site [chemical binding]; other site
744872007212	Mg2+ binding site [ion binding]; other site
744872007213	G-X-G motif; other site
744872007214	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
744872007215	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
744872007216	Walker A/P-loop; other site
744872007217	ATP binding site [chemical binding]; other site
744872007218	Q-loop/lid; other site
744872007219	ABC transporter signature motif; other site
744872007220	Walker B; other site
744872007221	D-loop; other site
744872007222	H-loop/switch region; other site
744872007223	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
744872007224	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
744872007225	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
744872007226	Walker A/P-loop; other site
744872007227	ATP binding site [chemical binding]; other site
744872007228	Q-loop/lid; other site
744872007229	ABC transporter signature motif; other site
744872007230	Walker B; other site
744872007231	D-loop; other site
744872007232	H-loop/switch region; other site
744872007233	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
744872007234	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
744872007235	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
744872007236	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872007237	dimer interface [polypeptide binding]; other site
744872007238	conserved gate region; other site
744872007239	putative PBP binding loops; other site
744872007240	ABC-ATPase subunit interface; other site
744872007241	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
744872007242	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872007243	dimer interface [polypeptide binding]; other site
744872007244	conserved gate region; other site
744872007245	putative PBP binding loops; other site
744872007246	ABC-ATPase subunit interface; other site
744872007247	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
744872007248	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
744872007249	peptide binding site [polypeptide binding]; other site
744872007250	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
744872007251	putative acyl-acceptor binding pocket; other site
744872007252	LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167
744872007253	putative metal binding site [ion binding]; other site
744872007254	LOTUS is an uncharacterized small globular domain found in Limkain b1, Oskar and Tudor-containing proteins 5 and 7; Region: LOTUS; cl14879
744872007255	DNA repair helicase rad25; Region: rad25; TIGR00603
744872007256	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872007257	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872007258	ATP binding site [chemical binding]; other site
744872007259	putative Mg++ binding site [ion binding]; other site
744872007260	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
744872007261	nucleotide binding region [chemical binding]; other site
744872007262	ATP-binding site [chemical binding]; other site
744872007263	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
744872007264	putative FMN binding site [chemical binding]; other site
744872007265	Cache domain; Region: Cache_1; pfam02743
744872007266	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
744872007267	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
744872007268	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
744872007269	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
744872007270	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
744872007271	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872007272	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
744872007273	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
744872007274	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
744872007275	dihydroorotase; Validated; Region: pyrC; PRK09357
744872007276	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281
744872007277	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C...; Region: DHOase_IIa; cd01317
744872007278	active site
744872007279	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725
744872007280	active site
744872007281	dimer interface [polypeptide binding]; other site
744872007282	2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543
744872007283	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
744872007284	FAD binding pocket [chemical binding]; other site
744872007285	FAD binding motif [chemical binding]; other site
744872007286	phosphate binding motif [ion binding]; other site
744872007287	beta-alpha-beta structure motif; other site
744872007288	NAD binding pocket [chemical binding]; other site
744872007289	Iron coordination center [ion binding]; other site
744872007290	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
744872007291	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
744872007292	heterodimer interface [polypeptide binding]; other site
744872007293	active site
744872007294	FMN binding site [chemical binding]; other site
744872007295	homodimer interface [polypeptide binding]; other site
744872007296	substrate binding site [chemical binding]; other site
744872007297	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
744872007298	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
744872007299	putative substrate translocation pore; other site
744872007300	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
744872007301	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
744872007302	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
744872007303	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
744872007304	DNA binding residues [nucleotide binding]
744872007305	GTP-binding protein Der; Reviewed; Region: PRK00093
744872007306	EngA1 subfamily.  This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains.  Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894
744872007307	G1 box; other site
744872007308	GTP/Mg2+ binding site [chemical binding]; other site
744872007309	Switch I region; other site
744872007310	G2 box; other site
744872007311	Switch II region; other site
744872007312	G3 box; other site
744872007313	G4 box; other site
744872007314	G5 box; other site
744872007315	EngA2 subfamily.  This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains.  Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895
744872007316	G1 box; other site
744872007317	GTP/Mg2+ binding site [chemical binding]; other site
744872007318	Switch I region; other site
744872007319	G2 box; other site
744872007320	G3 box; other site
744872007321	Switch II region; other site
744872007322	G4 box; other site
744872007323	G5 box; other site
744872007324	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
744872007325	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
744872007326	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
744872007327	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
744872007328	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293
744872007329	B12 binding site [chemical binding]; other site
744872007330	Radical SAM; Region: Elp3; smart00729
744872007331	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872007332	Response regulator receiver domain; Region: Response_reg; pfam00072
744872007333	active site
744872007334	phosphorylation site [posttranslational modification]
744872007335	intermolecular recognition site; other site
744872007336	dimerization interface [polypeptide binding]; other site
744872007337	cyclase homology domain; Region: CHD; cd07302
744872007338	nucleotidyl binding site; other site
744872007339	metal binding site [ion binding]; metal-binding site
744872007340	dimer interface [polypeptide binding]; other site
744872007341	DNA repair protein RadA; Provisional; Region: PRK11823
744872007342	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
744872007343	Walker A motif/ATP binding site; other site
744872007344	ATP binding site [chemical binding]; other site
744872007345	Walker B motif; other site
744872007346	RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590
744872007347	RNA/DNA binding site [nucleotide binding]; other site
744872007348	RRM dimerization site [polypeptide binding]; other site
744872007349	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
744872007350	active site
744872007351	phosphorylation site [posttranslational modification]
744872007352	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
744872007353	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl14895
744872007354	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
744872007355	N-acetyl-D-glucosamine binding site [chemical binding]; other site
744872007356	catalytic residue [active]
744872007357	2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410
744872007358	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872007359	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
744872007360	L-serine binding site [chemical binding]; other site
744872007361	ACT domain interface; other site
744872007362	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
744872007363	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
744872007364	catalytic residue [active]
744872007365	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872007366	HPr kinase/phosphorylase; Provisional; Region: PRK05428
744872007367	DRTGG domain; Region: DRTGG; cl12147
744872007368	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-...; Region: HprK_C; cd01918
744872007369	Hpr binding site; other site
744872007370	active site
744872007371	homohexamer subunit interaction site [polypeptide binding]; other site
744872007372	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
744872007373	dimerization domain swap beta strand [polypeptide binding]; other site
744872007374	regulatory protein interface [polypeptide binding]; other site
744872007375	active site
744872007376	regulatory phosphorylation site [posttranslational modification]; other site
744872007377	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
744872007378	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
744872007379	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225
744872007380	dimerization interface [polypeptide binding]; other site
744872007381	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
744872007382	dimer interface [polypeptide binding]; other site
744872007383	phosphorylation site [posttranslational modification]
744872007384	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872007385	ATP binding site [chemical binding]; other site
744872007386	Mg2+ binding site [ion binding]; other site
744872007387	G-X-G motif; other site
744872007388	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
744872007389	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872007390	active site
744872007391	phosphorylation site [posttranslational modification]
744872007392	intermolecular recognition site; other site
744872007393	dimerization interface [polypeptide binding]; other site
744872007394	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
744872007395	Walker A motif; other site
744872007396	ATP binding site [chemical binding]; other site
744872007397	Walker B motif; other site
744872007398	arginine finger; other site
744872007399	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
744872007400	LexA repressor; Validated; Region: PRK00215
744872007401	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529
744872007402	Catalytic site [active]
744872007403	DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466
744872007404	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
744872007405	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
744872007406	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872007407	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
744872007408	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
744872007409	substrate binding pocket [chemical binding]; other site
744872007410	chain length determination region; other site
744872007411	substrate-Mg2+ binding site; other site
744872007412	catalytic residues [active]
744872007413	aspartate-rich region 1; other site
744872007414	active site lid residues [active]
744872007415	aspartate-rich region 2; other site
744872007416	Domain of unknown function DUF; Region: DUF204; pfam02659
744872007417	Domain of unknown function DUF; Region: DUF204; pfam02659
744872007418	PUA domain; Region: PUA; cl00607
744872007419	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
744872007420	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
744872007421	S-adenosylmethionine binding site [chemical binding]; other site
744872007422	Polyphosphate kinase; Region: PP_kinase; pfam02503
744872007423	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
744872007424	putative domain interface [polypeptide binding]; other site
744872007425	putative active site [active]
744872007426	catalytic site [active]
744872007427	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
744872007428	putative domain interface [polypeptide binding]; other site
744872007429	putative active site [active]
744872007430	catalytic site [active]
744872007431	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
744872007432	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
744872007433	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
744872007434	Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626
744872007435	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801
744872007436	Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) [Translation, ribosomal structure and biogenesis]; Region: GatB; COG0064
744872007437	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
744872007438	GatB domain; Region: GatB_Yqey; cl11497
744872007439	Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases, one  highly specific for asparagine and localised to the...; Region: Asparaginase; cl00216
744872007440	active site/substrate binding site [active]
744872007441	tetramer interface [polypeptide binding]; other site
744872007442	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
744872007443	catalytic core [active]
744872007444	type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552
744872007445	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872007446	binding surface
744872007447	TPR motif; other site
744872007448	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872007449	binding surface
744872007450	Lipoprotein NlpI, contains TPR repeats [General function prediction only]; Region: NlpI; COG4785
744872007451	TPR motif; other site
744872007452	DHH family; Region: DHH; pfam01368
744872007453	Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916
744872007454	TraB family; Region: TraB; cl12050
744872007455	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
744872007456	Gram-negative bacterial tonB protein; Region: TonB; cl10048
744872007457	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
744872007458	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
744872007459	N-terminal plug; other site
744872007460	ligand-binding site [chemical binding]; other site
744872007461	Uncharacterized conserved protein [Function unknown]; Region: COG1912
744872007462	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
744872007463	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
744872007464	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872007465	dimer interface [polypeptide binding]; other site
744872007466	conserved gate region; other site
744872007467	putative PBP binding loops; other site
744872007468	ABC-ATPase subunit interface; other site
744872007469	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
744872007470	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
744872007471	substrate binding pocket [chemical binding]; other site
744872007472	membrane-bound complex binding site; other site
744872007473	hinge residues; other site
744872007474	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
744872007475	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872007476	active site
744872007477	phosphorylation site [posttranslational modification]
744872007478	intermolecular recognition site; other site
744872007479	dimerization interface [polypeptide binding]; other site
744872007480	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
744872007481	DNA binding site [nucleotide binding]
744872007482	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
744872007483	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225
744872007484	dimerization interface [polypeptide binding]; other site
744872007485	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
744872007486	dimer interface [polypeptide binding]; other site
744872007487	phosphorylation site [posttranslational modification]
744872007488	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872007489	ATP binding site [chemical binding]; other site
744872007490	Mg2+ binding site [ion binding]; other site
744872007491	G-X-G motif; other site
744872007492	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872007493	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
744872007494	Walker A/P-loop; other site
744872007495	ATP binding site [chemical binding]; other site
744872007496	Q-loop/lid; other site
744872007497	ABC transporter signature motif; other site
744872007498	Walker B; other site
744872007499	D-loop; other site
744872007500	H-loop/switch region; other site
744872007501	ABC-2 type transporter; Region: ABC2_membrane; cl11417
744872007502	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
744872007503	RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590
744872007504	RNA/DNA binding site [nucleotide binding]; other site
744872007505	RRM dimerization site [polypeptide binding]; other site
744872007506	Nitrate and nitrite sensing; Region: NIT; pfam08376
744872007507	TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956
744872007508	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
744872007509	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
744872007510	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
744872007511	GAF domain; Region: GAF; cl00853
744872007512	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
744872007513	Zn2+ binding site [ion binding]; other site
744872007514	Mg2+ binding site [ion binding]; other site
744872007515	Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins [General function prediction only]; Region: PflX; COG1313
744872007516	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
744872007517	FeS/SAM binding site; other site
744872007518	4-alpha-glucanotransferase; Provisional; Region: PLN03236
744872007519	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
744872007520	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
744872007521	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
744872007522	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
744872007523	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
744872007524	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
744872007525	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342
744872007526	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
744872007527	catalytic residue [active]
744872007528	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
744872007529	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
744872007530	substrate binding pocket [chemical binding]; other site
744872007531	membrane-bound complex binding site; other site
744872007532	hinge residues; other site
744872007533	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
744872007534	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872007535	dimer interface [polypeptide binding]; other site
744872007536	conserved gate region; other site
744872007537	putative PBP binding loops; other site
744872007538	ABC-ATPase subunit interface; other site
744872007539	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
744872007540	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262
744872007541	Walker A/P-loop; other site
744872007542	ATP binding site [chemical binding]; other site
744872007543	Q-loop/lid; other site
744872007544	ABC transporter signature motif; other site
744872007545	Walker B; other site
744872007546	D-loop; other site
744872007547	H-loop/switch region; other site
744872007548	Low molecular weight phosphatase family; Region: LMWPc; cd00115
744872007549	Active site [active]
744872007550	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
744872007551	dimerization interface [polypeptide binding]; other site
744872007552	putative DNA binding site [nucleotide binding]; other site
744872007553	putative Zn2+ binding site [ion binding]; other site
744872007554	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
744872007555	substrate binding site [chemical binding]; other site
744872007556	ATP binding site [chemical binding]; other site
744872007557	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872007558	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
744872007559	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
744872007560	Transcriptional regulators [Transcription]; Region: PurR; COG1609
744872007561	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
744872007562	DNA binding site [nucleotide binding]
744872007563	domain linker motif; other site
744872007564	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
744872007565	dimerization interface [polypeptide binding]; other site
744872007566	ligand binding site [chemical binding]; other site
744872007567	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
744872007568	DctM-like transporters; Region: DctM; pfam06808
744872007569	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
744872007570	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
744872007571	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710
744872007572	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
744872007573	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872007574	active site
744872007575	phosphorylation site [posttranslational modification]
744872007576	intermolecular recognition site; other site
744872007577	dimerization interface [polypeptide binding]; other site
744872007578	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
744872007579	Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850
744872007580	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
744872007581	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225
744872007582	dimerization interface [polypeptide binding]; other site
744872007583	Histidine kinase; Region: His_kinase; pfam06580
744872007584	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872007585	ATP binding site [chemical binding]; other site
744872007586	Mg2+ binding site [ion binding]; other site
744872007587	G-X-G motif; other site
744872007588	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
744872007589	putative active site [active]
744872007590	heme pocket [chemical binding]; other site
744872007591	GAF domain; Region: GAF; cl00853
744872007592	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
744872007593	metal binding site [ion binding]; metal-binding site
744872007594	active site
744872007595	I-site; other site
744872007596	NlpC/P60 family; Region: NLPC_P60; cl11438
744872007597	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
744872007598	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
744872007599	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
744872007600	TPP-binding site [chemical binding]; other site
744872007601	2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119
744872007602	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
744872007603	dimer interface [polypeptide binding]; other site
744872007604	PYR/PP interface [polypeptide binding]; other site
744872007605	TPP binding site [chemical binding]; other site
744872007606	substrate binding site [chemical binding]; other site
744872007607	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
744872007608	Ferredoxin [Energy production and conversion]; Region: COG1146
744872007609	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655
744872007610	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
744872007611	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
744872007612	Acetokinase family; Region: Acetate_kinase; cl01029
744872007613	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
744872007614	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
744872007615	peptidase T; Region: peptidase-T; TIGR01882
744872007616	M28, and M42; Region: Zinc_peptidase_like; cl14876
744872007617	metal binding site [ion binding]; metal-binding site
744872007618	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
744872007619	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
744872007620	DNA-binding site [nucleotide binding]; DNA binding site
744872007621	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
744872007622	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
744872007623	Walker A/P-loop; other site
744872007624	ATP binding site [chemical binding]; other site
744872007625	Q-loop/lid; other site
744872007626	ABC transporter signature motif; other site
744872007627	Walker B; other site
744872007628	D-loop; other site
744872007629	H-loop/switch region; other site
744872007630	cyclase homology domain; Region: CHD; cd07302
744872007631	nucleotidyl binding site; other site
744872007632	metal binding site [ion binding]; metal-binding site
744872007633	dimer interface [polypeptide binding]; other site
744872007634	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
744872007635	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
744872007636	putative trimer interface [polypeptide binding]; other site
744872007637	putative CoA binding site [chemical binding]; other site
744872007638	Trp repressor protein; Region: Trp_repressor; cl01121
744872007639	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
744872007640	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872007641	Walker A/P-loop; other site
744872007642	ATP binding site [chemical binding]; other site
744872007643	Q-loop/lid; other site
744872007644	ABC transporter signature motif; other site
744872007645	Walker B; other site
744872007646	D-loop; other site
744872007647	H-loop/switch region; other site
744872007648	ABC transporter; Region: ABC_tran_2; pfam12848
744872007649	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
744872007650	PAS fold; Region: PAS_4; pfam08448
744872007651	bacterio-opsin activator; Provisional; Region: PRK13558
744872007652	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
744872007653	putative active site [active]
744872007654	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
744872007655	heme pocket [chemical binding]; other site
744872007656	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
744872007657	dimer interface [polypeptide binding]; other site
744872007658	phosphorylation site [posttranslational modification]
744872007659	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872007660	ATP binding site [chemical binding]; other site
744872007661	Mg2+ binding site [ion binding]; other site
744872007662	G-X-G motif; other site
744872007663	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
744872007664	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
744872007665	metal binding site [ion binding]; metal-binding site
744872007666	active site
744872007667	I-site; other site
744872007668	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580
744872007669	TM-ABC transporter signature motif; other site
744872007670	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580
744872007671	TM-ABC transporter signature motif; other site
744872007672	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
744872007673	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872007674	Walker A/P-loop; other site
744872007675	ATP binding site [chemical binding]; other site
744872007676	Q-loop/lid; other site
744872007677	ABC transporter signature motif; other site
744872007678	Walker B; other site
744872007679	D-loop; other site
744872007680	H-loop/switch region; other site
744872007681	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215
744872007682	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
744872007683	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
744872007684	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
744872007685	putative active site [active]
744872007686	Phd_YefM; Region: PhdYeFM; cl09153
744872007687	PemK-like protein; Region: PemK; cl00995
744872007688	SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877
744872007689	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869
744872007690	active site
744872007691	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
744872007692	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
744872007693	Peptidase family M48; Region: Peptidase_M48; cl12018
744872007694	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
744872007695	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
744872007696	PYR/PP interface [polypeptide binding]; other site
744872007697	dimer interface [polypeptide binding]; other site
744872007698	TPP binding site [chemical binding]; other site
744872007699	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
744872007700	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
744872007701	TPP-binding site [chemical binding]; other site
744872007702	dimer interface [polypeptide binding]; other site
744872007703	Dehydratase family; Region: ILVD_EDD; cl00340
744872007704	dihydroxy-acid dehydratase; Region: ilvD; TIGR00110
744872007705	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
744872007706	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
744872007707	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
744872007708	active site
744872007709	catalytic residues [active]
744872007710	metal binding site [ion binding]; metal-binding site
744872007711	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
744872007712	2-isopropylmalate synthase; Validated; Region: PRK00915
744872007713	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
744872007714	active site
744872007715	catalytic residues [active]
744872007716	metal binding site [ion binding]; metal-binding site
744872007717	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
744872007718	ketol-acid reductoisomerase; Provisional; Region: PRK05479
744872007719	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872007720	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
744872007721	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
744872007722	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
744872007723	putative valine binding site [chemical binding]; other site
744872007724	dimer interface [polypeptide binding]; other site
744872007725	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
744872007726	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
744872007727	NeuB family; Region: NeuB; cl00496
744872007728	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
744872007729	Prephenate dehydratase; Region: PDT; pfam00800
744872007730	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
744872007731	putative L-Phe binding site [chemical binding]; other site
744872007732	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
744872007733	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
744872007734	active site
744872007735	motif I; other site
744872007736	motif II; other site
744872007737	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
744872007738	Predicted transcriptional regulator [Transcription]; Region: COG5340
744872007739	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973
744872007740	Protein of unknown function (DUF1007); Region: DUF1007; cl01487
744872007741	High-affinity nickel-transport protein; Region: NicO; cl00964
744872007742	High-affinity nickel-transport protein; Region: NicO; cl00964
744872007743	HipA N-terminal domain; Region: couple_hipA; TIGR03071
744872007744	HipA-like N-terminal domain; Region: HipA_N; pfam07805
744872007745	HipA-like C-terminal domain; Region: HipA_C; pfam07804
744872007746	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258
744872007747	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161
744872007748	Dehydratase family; Region: ILVD_EDD; cl00340
744872007749	dihydroxy-acid dehydratase; Region: ilvD; TIGR00110
744872007750	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
744872007751	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
744872007752	substrate binding site [chemical binding]; other site
744872007753	ligand binding site [chemical binding]; other site
744872007754	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577
744872007755	substrate binding site [chemical binding]; other site
744872007756	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
744872007757	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
744872007758	PYR/PP interface [polypeptide binding]; other site
744872007759	dimer interface [polypeptide binding]; other site
744872007760	TPP binding site [chemical binding]; other site
744872007761	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
744872007762	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
744872007763	TPP-binding site [chemical binding]; other site
744872007764	dimer interface [polypeptide binding]; other site
744872007765	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
744872007766	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
744872007767	putative valine binding site [chemical binding]; other site
744872007768	dimer interface [polypeptide binding]; other site
744872007769	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
744872007770	benzoate transport; Region: 2A0115; TIGR00895
744872007771	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
744872007772	putative substrate translocation pore; other site
744872007773	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
744872007774	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
744872007775	active site
744872007776	NTP binding site [chemical binding]; other site
744872007777	metal binding triad [ion binding]; metal-binding site
744872007778	antibiotic binding site [chemical binding]; other site
744872007779	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl08495
744872007780	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
744872007781	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
744872007782	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
744872007783	ATP binding site [chemical binding]; other site
744872007784	putative Mg++ binding site [ion binding]; other site
744872007785	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
744872007786	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
744872007787	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
744872007788	HsdM N-terminal domain; Region: HsdM_N; pfam12161
744872007789	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
744872007790	YcfA-like protein; Region: YcfA; cl00752
744872007791	Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691
744872007792	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
744872007793	Coenzyme A binding pocket [chemical binding]; other site
744872007794	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
744872007795	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872007796	ATP binding site [chemical binding]; other site
744872007797	Mg2+ binding site [ion binding]; other site
744872007798	G-X-G motif; other site
744872007799	yrdC domain; Region: Sua5_yciO_yrdC; cl00305
744872007800	SUA5 domain; Region: SUA5; pfam03481
744872007801	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
744872007802	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
744872007803	E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies.  These domains are associated with different types of catalytic domains at  either the N-terminal or C-terminal end; Region: E_set; cl09101
744872007804	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
744872007805	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
744872007806	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
744872007807	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
744872007808	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
744872007809	motif II; other site
744872007810	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
744872007811	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
744872007812	HIGH motif; other site
744872007813	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
744872007814	active site
744872007815	KMSKS motif; other site
744872007816	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
744872007817	tRNA binding surface [nucleotide binding]; other site
744872007818	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
744872007819	Cupin domain; Region: Cupin_2; cl09118
744872007820	Predicted integral membrane protein [Function unknown]; Region: COG0392
744872007821	Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219
744872007822	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
744872007823	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
744872007824	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
744872007825	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
744872007826	tetramer interface [polypeptide binding]; other site
744872007827	pyridoxal 5'-phosphate binding site [chemical binding]; other site
744872007828	catalytic residue [active]
744872007829	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
744872007830	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
744872007831	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate...; Region: APP_MetAP; cl00279
744872007832	active site
744872007833	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928
744872007834	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
744872007835	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881
744872007836	Predicted dehydrogenase [General function prediction only]; Region: COG0579
744872007837	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
744872007838	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
744872007839	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
744872007840	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872007841	binding surface
744872007842	TPR motif; other site
744872007843	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872007844	binding surface
744872007845	TPR motif; other site
744872007846	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
744872007847	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872007848	binding surface
744872007849	TPR motif; other site
744872007850	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872007851	binding surface
744872007852	TPR motif; other site
744872007853	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872007854	binding surface
744872007855	TPR motif; other site
744872007856	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872007857	binding surface
744872007858	TPR motif; other site
744872007859	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
744872007860	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
744872007861	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
744872007862	GIY-YIG motif/motif A; other site
744872007863	active site
744872007864	catalytic site [active]
744872007865	putative DNA binding site [nucleotide binding]; other site
744872007866	metal binding site [ion binding]; metal-binding site
744872007867	UvrB/uvrC motif; Region: UVR; pfam02151
744872007868	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
744872007869	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
744872007870	DNA binding site [nucleotide binding]
744872007871	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cl00250
744872007872	30S subunit binding site; other site
744872007873	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
744872007874	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
744872007875	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
744872007876	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
744872007877	Protein of unknown function (DUF1015); Region: DUF1015; cl01715
744872007878	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
744872007879	D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813
744872007880	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
744872007881	anti sigma factor interaction site; other site
744872007882	regulatory phosphorylation site [posttranslational modification]; other site
744872007883	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
744872007884	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
744872007885	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
744872007886	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
744872007887	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
744872007888	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage...; Region: UMPK; cd02023
744872007889	ATP-binding site [chemical binding]; other site
744872007890	Sugar specificity; other site
744872007891	Pyrimidine base specificity; other site
744872007892	Sodium:neurotransmitter symporter family; Region: SNF; cl11976
744872007893	chaperone protein DnaJ; Provisional; Region: PRK10767
744872007894	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257
744872007895	HSP70 interaction site [polypeptide binding]; other site
744872007896	DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908
744872007897	DnaJ C terminal domain; Region: DnaJ_C; pfam01556
744872007898	DnaJ C terminal domain; Region: DnaJ_C; pfam01556
744872007899	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
744872007900	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446
744872007901	dimer interface [polypeptide binding]; other site
744872007902	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
744872007903	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
744872007904	Bacitracin resistance protein BacA; Region: BacA; cl00858
744872007905	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
744872007906	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
744872007907	PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553
744872007908	active site
744872007909	uracil binding [chemical binding]; other site
744872007910	L-rhamnose isomerase (RhaA); Region: RhaA; cl09945
744872007911	D-xylulose kinases, subgroup 1; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809
744872007912	N- and C-terminal domain interface [polypeptide binding]; other site
744872007913	D-xylulose kinase; Region: XylB; TIGR01312
744872007914	active site
744872007915	catalytic site [active]
744872007916	metal binding site [ion binding]; metal-binding site
744872007917	xylulose binding site [chemical binding]; other site
744872007918	ATP binding site [chemical binding]; other site
744872007919	putative homodimer interface [polypeptide binding]; other site
744872007920	Cupin domain; Region: Cupin_2; cl09118
744872007921	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
744872007922	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
744872007923	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
744872007924	Response regulator receiver domain; Region: Response_reg; pfam00072
744872007925	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872007926	active site
744872007927	phosphorylation site [posttranslational modification]
744872007928	intermolecular recognition site; other site
744872007929	dimerization interface [polypeptide binding]; other site
744872007930	PAS domain S-box; Region: sensory_box; TIGR00229
744872007931	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
744872007932	PAS domain S-box; Region: sensory_box; TIGR00229
744872007933	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
744872007934	Histidine kinase; Region: HisKA_2; cl06527
744872007935	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872007936	ATP binding site [chemical binding]; other site
744872007937	Mg2+ binding site [ion binding]; other site
744872007938	G-X-G motif; other site
744872007939	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
744872007940	mce related protein; Region: MCE; pfam02470
744872007941	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
744872007942	ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261
744872007943	Walker A/P-loop; other site
744872007944	ATP binding site [chemical binding]; other site
744872007945	Q-loop/lid; other site
744872007946	ABC transporter signature motif; other site
744872007947	Walker B; other site
744872007948	D-loop; other site
744872007949	H-loop/switch region; other site
744872007950	Domain of unknown function DUF140; Region: DUF140; cl00510
744872007951	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872007952	binding surface
744872007953	TPR motif; other site
744872007954	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
744872007955	mce related protein; Region: MCE; pfam02470
744872007956	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
744872007957	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872007958	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
744872007959	Walker A/P-loop; other site
744872007960	ATP binding site [chemical binding]; other site
744872007961	Q-loop/lid; other site
744872007962	ABC transporter signature motif; other site
744872007963	Walker B; other site
744872007964	D-loop; other site
744872007965	H-loop/switch region; other site
744872007966	Domain of unknown function DUF140; Region: DUF140; cl00510
744872007967	Sporulation and spore germination; Region: Germane; cl11253
744872007968	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
744872007969	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
744872007970	putative active site [active]
744872007971	metal binding site [ion binding]; metal-binding site
744872007972	homodimer binding site [polypeptide binding]; other site
744872007973	conserved hypothetical protein YmdA/YtgF; Region: YmdA_YtgF; TIGR03319
744872007974	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
744872007975	Zn2+ binding site [ion binding]; other site
744872007976	Mg2+ binding site [ion binding]; other site
744872007977	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
744872007978	The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218
744872007979	Walker A/P-loop; other site
744872007980	ATP binding site [chemical binding]; other site
744872007981	Q-loop/lid; other site
744872007982	ABC transporter signature motif; other site
744872007983	Walker B; other site
744872007984	D-loop; other site
744872007985	H-loop/switch region; other site
744872007986	OstA-like protein; Region: OstA; cl00844
744872007987	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
744872007988	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
744872007989	CTP synthetase; Validated; Region: pyrG; PRK05380
744872007990	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113
744872007991	Catalytic site [active]
744872007992	Active site [active]
744872007993	UTP binding site [chemical binding]; other site
744872007994	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
744872007995	active site
744872007996	putative oxyanion hole; other site
744872007997	catalytic triad [active]
744872007998	Uncharacterised ACR, COG1259; Region: DUF151; cl00553
744872007999	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
744872008000	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
744872008001	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
744872008002	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
744872008003	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872008004	active site
744872008005	phosphorylation site [posttranslational modification]
744872008006	intermolecular recognition site; other site
744872008007	dimerization interface [polypeptide binding]; other site
744872008008	CheB methylesterase; Region: CheB_methylest; pfam01339
744872008009	Transglycosylase; Region: Transgly; cl07896
744872008010	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872008011	binding surface
744872008012	TPR motif; other site
744872008013	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872008014	binding surface
744872008015	TPR motif; other site
744872008016	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872008017	binding surface
744872008018	TPR motif; other site
744872008019	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
744872008020	active site
744872008021	metal binding site [ion binding]; metal-binding site
744872008022	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178
744872008023	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464
744872008024	putative dimer interface [polypeptide binding]; other site
744872008025	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
744872008026	catalytic loop [active]
744872008027	iron binding site [ion binding]; other site
744872008028	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
744872008029	hydrogenase, Fe-only; Region: Fe_only_hydrog; TIGR02512
744872008030	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
744872008031	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; cl03503
744872008032	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:; Region: TRX_Fd_family; cd02980
744872008033	dimer interface [polypeptide binding]; other site
744872008034	[2Fe-2S] cluster binding site [ion binding]; other site
744872008035	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
744872008036	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
744872008037	SLBB domain; Region: SLBB; pfam10531
744872008038	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
744872008039	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
744872008040	4Fe-4S binding domain; Region: Fer4; cl02805
744872008041	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:; Region: TRX_Fd_family; cd02980
744872008042	dimer interface [polypeptide binding]; other site
744872008043	[2Fe-2S] cluster binding site [ion binding]; other site
744872008044	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872008045	ATP binding site [chemical binding]; other site
744872008046	Mg2+ binding site [ion binding]; other site
744872008047	G-X-G motif; other site
744872008048	NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958
744872008049	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of...; Region: TRX_Fd_NuoE; cd03064
744872008050	putative dimer interface [polypeptide binding]; other site
744872008051	[2Fe-2S] cluster binding site [ion binding]; other site
744872008052	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
744872008053	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
744872008054	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
744872008055	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
744872008056	Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG1102
744872008057	Protein of unknown function (DUF1062); Region: DUF1062; cl01786
744872008058	PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379
744872008059	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
744872008060	DRTGG domain; Region: DRTGG; cl12147
744872008061	FOG: CBS domain [General function prediction only]; Region: COG0517
744872008062	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cd02205
744872008063	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
744872008064	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
744872008065	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
744872008066	motif II; other site
744872008067	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
744872008068	DRTGG domain; Region: DRTGG; cl12147
744872008069	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
744872008070	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
744872008071	trimer interface [polypeptide binding]; other site
744872008072	putative metal binding site [ion binding]; other site
744872008073	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
744872008074	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042
744872008075	P-loop; other site
744872008076	Magnesium ion binding site [ion binding]; other site
744872008077	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042
744872008078	Magnesium ion binding site [ion binding]; other site
744872008079	ParB-like partition proteins; Region: parB_part; TIGR00180
744872008080	ParB-like nuclease domain; Region: ParBc; cl02129
744872008081	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
744872008082	active site
744872008083	phosphorylation site [posttranslational modification]
744872008084	intermolecular recognition site; other site
744872008085	dimerization interface [polypeptide binding]; other site
744872008086	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
744872008087	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
744872008088	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
744872008089	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
744872008090	pyridoxal 5'-phosphate binding site [chemical binding]; other site
744872008091	catalytic residue [active]
744872008092	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
744872008093	active site
744872008094	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
744872008095	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
744872008096	Walker A motif; other site
744872008097	ATP binding site [chemical binding]; other site
744872008098	Walker B motif; other site
744872008099	arginine finger; other site
744872008100	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
744872008101	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
744872008102	Walker A motif; other site
744872008103	ATP binding site [chemical binding]; other site
744872008104	Walker B motif; other site
744872008105	arginine finger; other site
744872008106	Protein of unknown function DUF262; Region: DUF262; cl14890
744872008107	Protein of unknown function DUF262; Region: DUF262; cl14890
744872008108	Predicted transcriptional regulator [Transcription]; Region: COG2378
744872008109	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
744872008110	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
744872008111	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872008112	Walker A/P-loop; other site
744872008113	ATP binding site [chemical binding]; other site
744872008114	Q-loop/lid; other site
744872008115	ABC transporter signature motif; other site
744872008116	Walker B; other site
744872008117	D-loop; other site
744872008118	H-loop/switch region; other site
744872008119	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
744872008120	TM-ABC transporter signature motif; other site
744872008121	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG2984
744872008122	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
744872008123	zinc binding site [ion binding]; other site
744872008124	putative ligand binding site [chemical binding]; other site
744872008125	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
744872008126	Malic enzyme, N-terminal domain; Region: malic; pfam00390
744872008127	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
744872008128	putative NAD(P) binding site [chemical binding]; other site
744872008129	PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855
744872008130	putative active site [active]
744872008131	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
744872008132	prolyl-tRNA synthetase; Provisional; Region: PRK09194
744872008133	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779
744872008134	dimer interface [polypeptide binding]; other site
744872008135	motif 1; other site
744872008136	active site
744872008137	motif 2; other site
744872008138	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334
744872008139	putative deacylase active site [active]
744872008140	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
744872008141	active site
744872008142	motif 3; other site
744872008143	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861
744872008144	anticodon binding site; other site
744872008145	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
744872008146	phosphate binding site [ion binding]; other site
744872008147	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
744872008148	homodimer interface [polypeptide binding]; other site
744872008149	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
744872008150	active site pocket [active]
744872008151	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme; Region: NifX_NifB; cd00562
744872008152	Phosphotransferase enzyme family; Region: APH; pfam01636
744872008153	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
744872008154	active site
744872008155	ATP binding site [chemical binding]; other site
744872008156	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
744872008157	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872008158	Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774
744872008159	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
744872008160	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
744872008161	TM-ABC transporter signature motif; other site
744872008162	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
744872008163	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216
744872008164	Walker A/P-loop; other site
744872008165	ATP binding site [chemical binding]; other site
744872008166	Q-loop/lid; other site
744872008167	ABC transporter signature motif; other site
744872008168	Walker B; other site
744872008169	D-loop; other site
744872008170	H-loop/switch region; other site
744872008171	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215
744872008172	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
744872008173	putative ligand binding site [chemical binding]; other site
744872008174	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
744872008175	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
744872008176	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
744872008177	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
744872008178	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216
744872008179	Walker A/P-loop; other site
744872008180	ATP binding site [chemical binding]; other site
744872008181	Q-loop/lid; other site
744872008182	ABC transporter signature motif; other site
744872008183	Walker B; other site
744872008184	D-loop; other site
744872008185	H-loop/switch region; other site
744872008186	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215
744872008187	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214
744872008188	intersubunit interface [polypeptide binding]; other site
744872008189	active site
744872008190	Zn2+ binding site [ion binding]; other site
744872008191	L-arabinose isomerase; Provisional; Region: PRK02929
744872008192	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of...; Region: L-fuc_L-ara-isomerases; cl00947
744872008193	hexamer (dimer of trimers) interface [polypeptide binding]; other site
744872008194	trimer interface [polypeptide binding]; other site
744872008195	substrate binding site [chemical binding]; other site
744872008196	Mn binding site [ion binding]; other site
744872008197	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
744872008198	MatE; Region: MatE; cl10513
744872008199	Putative esterase; Region: Esterase; pfam00756
744872008200	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
744872008201	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
744872008202	Uncharacterized conserved protein [Function unknown]; Region: COG2006
744872008203	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
744872008204	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
744872008205	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
744872008206	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
744872008207	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
744872008208	Beta-Casp domain; Region: Beta-Casp; cl12567
744872008209	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
744872008210	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
744872008211	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872008212	Protein of unknown function (DUF2804); Region: DUF2804; pfam10974
744872008213	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
744872008214	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872008215	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
744872008216	Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105
744872008217	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
744872008218	substrate binding pocket [chemical binding]; other site
744872008219	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
744872008220	B12 binding site [chemical binding]; other site
744872008221	cobalt ligand [ion binding]; other site
744872008222	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
744872008223	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586
744872008224	active site
744872008225	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
744872008226	active site 2 [active]
744872008227	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cl00246
744872008228	FAD binding site [chemical binding]; other site
744872008229	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl01869
744872008230	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872008231	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
744872008232	Walker A/P-loop; other site
744872008233	ATP binding site [chemical binding]; other site
744872008234	Q-loop/lid; other site
744872008235	ABC transporter signature motif; other site
744872008236	Walker B; other site
744872008237	D-loop; other site
744872008238	H-loop/switch region; other site
744872008239	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
744872008240	ligand binding site [chemical binding]; other site
744872008241	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
744872008242	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
744872008243	dimer interface [polypeptide binding]; other site
744872008244	phosphorylation site [posttranslational modification]
744872008245	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
744872008246	ATP binding site [chemical binding]; other site
744872008247	Mg2+ binding site [ion binding]; other site
744872008248	G-X-G motif; other site
744872008249	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
744872008250	Isoamylase N-terminus domain. Isoamylase (aka glycogen 6-glucanohydrolase) is one of the starch-debranching enzymes that catalyzes the hydrolysis of alpha-1,6-glucosidic linkages specific in alpha-glucans such as amylopectin or glycogen. Isoamylase...; Region: Isoamylase_N_term; cd02852
744872008251	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
744872008252	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
744872008253	ligand binding site [chemical binding]; other site
744872008254	flexible hinge region; other site
744872008255	Leucyl/phenylalanyl-tRNA protein transferase; Region: Leu_Phe_trans; cl01006
744872008256	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
744872008257	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872008258	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
744872008259	Cation transport protein; Region: TrkH; cl10514
744872008260	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
744872008261	Cation transport protein; Region: TrkH; cl10514
744872008262	Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893
744872008263	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872008264	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
744872008265	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872008266	dimer interface [polypeptide binding]; other site
744872008267	conserved gate region; other site
744872008268	putative PBP binding loops; other site
744872008269	ABC-ATPase subunit interface; other site
744872008270	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
744872008271	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
744872008272	dimer interface [polypeptide binding]; other site
744872008273	conserved gate region; other site
744872008274	putative PBP binding loops; other site
744872008275	ABC-ATPase subunit interface; other site
744872008276	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
744872008277	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
744872008278	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
744872008279	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013
744872008280	putative active site [active]
744872008281	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
744872008282	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
744872008283	putative NAD(P) binding site [chemical binding]; other site
744872008284	catalytic Zn binding site [ion binding]; other site
744872008285	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
744872008286	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
744872008287	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
744872008288	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
744872008289	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
744872008290	Walker A motif; other site
744872008291	ATP binding site [chemical binding]; other site
744872008292	Walker B motif; other site
744872008293	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
744872008294	arginine finger; other site
744872008295	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
744872008296	Protein of unknown function DUF58; Region: DUF58; pfam01882
744872008297	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
744872008298	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
744872008299	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
744872008300	TPR motif; other site
744872008301	binding surface
744872008302	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
744872008303	Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939
744872008304	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
744872008305	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
744872008306	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
744872008307	S-adenosylmethionine synthetase; Validated; Region: PRK05250
744872008308	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
744872008309	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
744872008310	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
744872008311	RF-1 domain; Region: RF-1; cl02875
744872008312	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
744872008313	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
744872008314	Coenzyme A binding pocket [chemical binding]; other site
744872008315	NlpC/P60 family; Region: NLPC_P60; cl11438
744872008316	PemK-like protein; Region: PemK; cl00995
744872008317	DNA gyrase subunit A; Validated; Region: PRK05560
744872008318	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187
744872008319	CAP-like domain; other site
744872008320	Active site [active]
744872008321	primary dimer interface [polypeptide binding]; other site
744872008322	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
744872008323	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
744872008324	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
744872008325	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
744872008326	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
744872008327	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
744872008328	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
744872008329	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822
744872008330	anchoring element; other site
744872008331	dimer interface [polypeptide binding]; other site
744872008332	ATP binding site [chemical binding]; other site
744872008333	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366
744872008334	active site
744872008335	putative metal-binding site [ion binding]; other site
744872008336	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986