-- dump date 20120504_162145 -- class Genbank::misc_feature -- table misc_feature_note -- id note 681288000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 681288000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 681288000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 681288000004 Walker A motif; other site 681288000005 ATP binding site [chemical binding]; other site 681288000006 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288000007 Walker B motif; other site 681288000008 arginine finger; other site 681288000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 681288000010 DnaA box-binding interface [nucleotide binding]; other site 681288000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 681288000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 681288000013 putative DNA binding surface [nucleotide binding]; other site 681288000014 dimer interface [polypeptide binding]; other site 681288000015 beta-clamp/clamp loader binding surface; other site 681288000016 beta-clamp/translesion DNA polymerase binding surface; other site 681288000017 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 681288000018 recF protein; Region: recf; TIGR00611 681288000019 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 681288000020 Walker A/P-loop; other site 681288000021 ATP binding site [chemical binding]; other site 681288000022 Q-loop/lid; other site 681288000023 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288000024 ABC transporter signature motif; other site 681288000025 Walker B; other site 681288000026 D-loop; other site 681288000027 H-loop/switch region; other site 681288000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 681288000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 681288000030 Mg2+ binding site [ion binding]; other site 681288000031 G-X-G motif; other site 681288000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 681288000033 anchoring element; other site 681288000034 dimer interface [polypeptide binding]; other site 681288000035 ATP binding site [chemical binding]; other site 681288000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 681288000037 active site 681288000038 putative metal-binding site [ion binding]; other site 681288000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 681288000040 DNA gyrase subunit A; Validated; Region: PRK05560 681288000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 681288000042 CAP-like domain; other site 681288000043 active site 681288000044 primary dimer interface [polypeptide binding]; other site 681288000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 681288000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 681288000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 681288000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 681288000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 681288000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 681288000051 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 681288000052 putative substrate binding site [chemical binding]; other site 681288000053 putative ATP binding site [chemical binding]; other site 681288000054 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 681288000055 active sites [active] 681288000056 tetramer interface [polypeptide binding]; other site 681288000057 SAAV_0009 681288000058 seryl-tRNA synthetase; Provisional; Region: PRK05431 681288000059 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 681288000060 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 681288000061 dimer interface [polypeptide binding]; other site 681288000062 active site 681288000063 motif 1; other site 681288000064 motif 2; other site 681288000065 motif 3; other site 681288000066 AzlC protein; Region: AzlC; cl00570 681288000067 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 681288000068 SAAV_0013 681288000069 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 681288000070 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 681288000071 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 681288000072 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 681288000073 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 681288000074 DHH family; Region: DHH; pfam01368 681288000075 DHHA1 domain; Region: DHHA1; pfam02272 681288000076 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 681288000077 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 681288000078 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 681288000079 replicative DNA helicase; Region: DnaB; TIGR00665 681288000080 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 681288000081 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 681288000082 Walker A motif; other site 681288000083 ATP binding site [chemical binding]; other site 681288000084 Walker B motif; other site 681288000085 DNA binding loops [nucleotide binding] 681288000086 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 681288000087 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 681288000088 GDP-binding site [chemical binding]; other site 681288000089 ACT binding site; other site 681288000090 IMP binding site; other site 681288000091 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 681288000092 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 681288000093 active site 681288000094 phosphorylation site [posttranslational modification] 681288000095 intermolecular recognition site; other site 681288000096 dimerization interface [polypeptide binding]; other site 681288000097 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 681288000098 DNA binding site [nucleotide binding] 681288000099 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 681288000100 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 681288000101 dimerization interface [polypeptide binding]; other site 681288000102 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 681288000103 putative active site [active] 681288000104 heme pocket [chemical binding]; other site 681288000105 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 681288000106 dimer interface [polypeptide binding]; other site 681288000107 phosphorylation site [posttranslational modification] 681288000108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 681288000109 ATP binding site [chemical binding]; other site 681288000110 Mg2+ binding site [ion binding]; other site 681288000111 G-X-G motif; other site 681288000112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 681288000113 YycH protein; Region: YycH; pfam07435 681288000114 YycH protein; Region: YycI; cl02015 681288000115 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 681288000116 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 681288000117 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 681288000118 putative active site [active] 681288000119 putative metal binding site [ion binding]; other site 681288000120 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 681288000121 Gram positive anchor; Region: Gram_pos_anchor; cl15427 681288000122 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 681288000123 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 681288000124 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 681288000125 phosphate binding site [ion binding]; other site 681288000126 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 681288000127 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 681288000128 putative homodimer interface [polypeptide binding]; other site 681288000129 putative homotetramer interface [polypeptide binding]; other site 681288000130 putative metal binding site [ion binding]; other site 681288000131 putative homodimer-homodimer interface [polypeptide binding]; other site 681288000132 putative allosteric switch controlling residues; other site 681288000133 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 681288000134 active site residue [active] 681288000135 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 681288000136 CPxP motif; other site 681288000137 DsrE/DsrF-like family; Region: DrsE; cl00672 681288000138 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 681288000139 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 681288000140 active site residue [active] 681288000141 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 681288000142 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 681288000143 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 681288000144 FMN binding site [chemical binding]; other site 681288000145 active site 681288000146 catalytic residues [active] 681288000147 substrate binding site [chemical binding]; other site 681288000148 TfoX N-terminal domain; Region: TfoX_N; cl01167 681288000149 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 681288000150 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288000151 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288000152 Family description; Region: UvrD_C_2; cl15862 681288000153 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 681288000154 active site 681288000155 catalytic site [active] 681288000156 putative metal binding site [ion binding]; other site 681288000157 Protein of unknown function, DUF576; Region: DUF576; cl04553 681288000158 Protein of unknown function, DUF576; Region: DUF576; cl04553 681288000159 Protein of unknown function, DUF576; Region: DUF576; cl04553 681288000160 Integrase core domain; Region: rve; cl01316 681288000161 Integrase core domain; Region: rve_3; cl15866 681288000162 Helix-turn-helix domains; Region: HTH; cl00088 681288000163 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 681288000164 Helix-turn-helix domains; Region: HTH; cl00088 681288000165 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 681288000166 Surface antigen [General function prediction only]; Region: COG3942 681288000167 NlpC/P60 family; Region: NLPC_P60; cl11438 681288000168 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288000169 Mitochondrial 28S ribosomal protein S30 (PDCD9); Region: PDCD9; pfam07147 681288000170 AAA-like domain; Region: AAA_10; pfam12846 681288000171 TcpE family; Region: TcpE; pfam12648 681288000172 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 681288000173 Replication initiation factor; Region: Rep_trans; pfam02486 681288000174 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 681288000175 glyoxylate carboligase; Provisional; Region: PRK11269 681288000176 Protein of unknown function, DUF576; Region: DUF576; cl04553 681288000177 Protein of unknown function, DUF576; Region: DUF576; cl04553 681288000178 Protein of unknown function, DUF576; Region: DUF576; cl04553 681288000179 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 681288000180 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 681288000181 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 681288000182 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 681288000183 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 681288000184 metal binding site [ion binding]; metal-binding site 681288000185 dimer interface [polypeptide binding]; other site 681288000186 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288000187 Major Facilitator Superfamily; Region: MFS_1; pfam07690 681288000188 putative substrate translocation pore; other site 681288000189 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288000190 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 681288000191 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 681288000192 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 681288000193 PhoU domain; Region: PhoU; pfam01895 681288000194 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288000195 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 681288000196 EamA-like transporter family; Region: EamA; cl01037 681288000197 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 681288000198 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 681288000199 DNA-binding site [nucleotide binding]; DNA binding site 681288000200 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 681288000201 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288000202 homodimer interface [polypeptide binding]; other site 681288000203 catalytic residue [active] 681288000204 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 681288000205 glycolate transporter; Provisional; Region: PRK09695 681288000206 L-lactate permease; Region: Lactate_perm; cl00701 681288000207 Helix-turn-helix domains; Region: HTH; cl00088 681288000208 Helix-turn-helix domains; Region: HTH; cl00088 681288000209 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 681288000210 ABC-ATPase subunit interface; other site 681288000211 dimer interface [polypeptide binding]; other site 681288000212 putative PBP binding regions; other site 681288000213 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 681288000214 ABC-ATPase subunit interface; other site 681288000215 dimer interface [polypeptide binding]; other site 681288000216 putative PBP binding regions; other site 681288000217 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 681288000218 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 681288000219 siderophore binding site; other site 681288000220 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 681288000221 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288000222 catalytic residue [active] 681288000223 dimer interface [polypeptide binding]; other site 681288000224 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 681288000225 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288000226 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 681288000227 IucA / IucC family; Region: IucA_IucC; pfam04183 681288000228 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 681288000229 drug efflux system protein MdtG; Provisional; Region: PRK09874 681288000230 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288000231 putative substrate translocation pore; other site 681288000232 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 681288000233 IucA / IucC family; Region: IucA_IucC; pfam04183 681288000234 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 681288000235 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 681288000236 IucA / IucC family; Region: IucA_IucC; pfam04183 681288000237 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 681288000238 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 681288000239 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 681288000240 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 681288000241 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 681288000242 dimer interface [polypeptide binding]; other site 681288000243 active site 681288000244 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 681288000245 catalytic residues [active] 681288000246 substrate binding site [chemical binding]; other site 681288000247 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 681288000248 ParB-like nuclease domain; Region: ParBc; cl02129 681288000249 acetoin reductase; Validated; Region: PRK08643 681288000250 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 681288000251 NAD binding site [chemical binding]; other site 681288000252 homotetramer interface [polypeptide binding]; other site 681288000253 homodimer interface [polypeptide binding]; other site 681288000254 active site 681288000255 substrate binding site [chemical binding]; other site 681288000256 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288000257 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 681288000258 NAD(P) binding site [chemical binding]; other site 681288000259 active site 681288000260 Bacterial sugar transferase; Region: Bac_transf; cl00939 681288000261 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 681288000262 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 681288000263 putative ADP-binding pocket [chemical binding]; other site 681288000264 O-Antigen Polymerase; Region: Wzy_C; cl04850 681288000265 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 681288000266 MatE; Region: MatE; cl10513 681288000267 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 681288000268 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 681288000269 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 681288000270 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 681288000271 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 681288000272 DNA-binding site [nucleotide binding]; DNA binding site 681288000273 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 681288000274 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 681288000275 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 681288000276 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 681288000277 intersubunit interface [polypeptide binding]; other site 681288000278 active site 681288000279 catalytic residue [active] 681288000280 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 681288000281 Sulfatase; Region: Sulfatase; cl10460 681288000282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288000283 dimer interface [polypeptide binding]; other site 681288000284 conserved gate region; other site 681288000285 putative PBP binding loops; other site 681288000286 ABC-ATPase subunit interface; other site 681288000287 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 681288000288 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288000289 dimer interface [polypeptide binding]; other site 681288000290 conserved gate region; other site 681288000291 ABC-ATPase subunit interface; other site 681288000292 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 681288000293 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 681288000294 Walker A/P-loop; other site 681288000295 ATP binding site [chemical binding]; other site 681288000296 Q-loop/lid; other site 681288000297 ABC transporter signature motif; other site 681288000298 Walker B; other site 681288000299 D-loop; other site 681288000300 H-loop/switch region; other site 681288000301 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 681288000302 NMT1-like family; Region: NMT1_2; cl15260 681288000303 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 681288000304 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 681288000305 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 681288000306 active site 681288000307 metal binding site [ion binding]; metal-binding site 681288000308 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 681288000309 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 681288000310 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 681288000311 non-specific DNA binding site [nucleotide binding]; other site 681288000312 salt bridge; other site 681288000313 sequence-specific DNA binding site [nucleotide binding]; other site 681288000314 Domain of unknown function (DUF955); Region: DUF955; cl01076 681288000315 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 681288000316 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 681288000317 putative catalytic cysteine [active] 681288000318 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 681288000319 putative active site [active] 681288000320 metal binding site [ion binding]; metal-binding site 681288000321 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 681288000322 Chain length determinant protein; Region: Wzz; cl15801 681288000323 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 681288000324 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288000325 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 681288000326 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 681288000327 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288000328 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 681288000329 NAD(P) binding site [chemical binding]; other site 681288000330 homodimer interface [polypeptide binding]; other site 681288000331 substrate binding site [chemical binding]; other site 681288000332 active site 681288000333 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 681288000334 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 681288000335 NAD(P) binding site [chemical binding]; other site 681288000336 homodimer interface [polypeptide binding]; other site 681288000337 substrate binding site [chemical binding]; other site 681288000338 active site 681288000339 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 681288000340 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 681288000341 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 681288000342 putative NAD(P) binding site [chemical binding]; other site 681288000343 active site 681288000344 putative substrate binding site [chemical binding]; other site 681288000345 Cupin domain; Region: Cupin_2; cl09118 681288000346 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 681288000347 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 681288000348 active site 681288000349 homodimer interface [polypeptide binding]; other site 681288000350 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 681288000351 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 681288000352 trimer interface [polypeptide binding]; other site 681288000353 active site 681288000354 substrate binding site [chemical binding]; other site 681288000355 CoA binding site [chemical binding]; other site 681288000356 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 681288000357 O-Antigen ligase; Region: Wzy_C; cl04850 681288000358 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 681288000359 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 681288000360 Bacterial sugar transferase; Region: Bac_transf; cl00939 681288000361 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 681288000362 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 681288000363 putative NAD(P) binding site [chemical binding]; other site 681288000364 active site 681288000365 putative substrate binding site [chemical binding]; other site 681288000366 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 681288000367 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288000368 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 681288000369 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288000370 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 681288000371 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 681288000372 active site 681288000373 homodimer interface [polypeptide binding]; other site 681288000374 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 681288000375 Protein of unknown function (DUF454); Region: DUF454; cl01063 681288000376 Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117 681288000377 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 681288000378 NAD(P) binding site [chemical binding]; other site 681288000379 catalytic residues [active] 681288000380 Cation efflux family; Region: Cation_efflux; cl00316 681288000381 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 681288000382 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 681288000383 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 681288000384 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 681288000385 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 681288000386 Walker A/P-loop; other site 681288000387 ATP binding site [chemical binding]; other site 681288000388 Q-loop/lid; other site 681288000389 ABC transporter signature motif; other site 681288000390 Walker B; other site 681288000391 D-loop; other site 681288000392 H-loop/switch region; other site 681288000393 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 681288000394 NMT1-like family; Region: NMT1_2; cl15260 681288000395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 681288000396 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 681288000397 active site 681288000398 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 681288000399 putative transporter; Provisional; Region: PRK10054 681288000400 Condensation domain; Region: Condensation; pfam00668 681288000401 peptide synthase; Provisional; Region: PRK12316 681288000402 AMP-binding enzyme; Region: AMP-binding; cl15778 681288000403 Phosphopantetheine attachment site; Region: PP-binding; cl09936 681288000404 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 681288000405 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 681288000406 AMP-binding enzyme; Region: AMP-binding; cl15778 681288000407 acetyl-CoA synthetase; Provisional; Region: PRK00174 681288000408 Phosphopantetheine attachment site; Region: PP-binding; cl09936 681288000409 thioester reductase domain; Region: Thioester-redct; TIGR01746 681288000410 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288000411 NAD(P) binding site [chemical binding]; other site 681288000412 active site 681288000413 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 681288000414 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 681288000415 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 681288000416 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 681288000417 nucleotide binding site [chemical binding]; other site 681288000418 N-acetyl-L-glutamate binding site [chemical binding]; other site 681288000419 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 681288000420 heterotetramer interface [polypeptide binding]; other site 681288000421 active site pocket [active] 681288000422 cleavage site 681288000423 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 681288000424 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288000425 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 681288000426 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 681288000427 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 681288000428 inhibitor-cofactor binding pocket; inhibition site 681288000429 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288000430 catalytic residue [active] 681288000431 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 681288000432 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 681288000433 catalytic triad [active] 681288000434 conserved cis-peptide bond; other site 681288000435 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 681288000436 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 681288000437 dimer interface [polypeptide binding]; other site 681288000438 PYR/PP interface [polypeptide binding]; other site 681288000439 TPP binding site [chemical binding]; other site 681288000440 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 681288000441 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 681288000442 TPP-binding site [chemical binding]; other site 681288000443 dimer interface [polypeptide binding]; other site 681288000444 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 681288000445 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 681288000446 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 681288000447 active site turn [active] 681288000448 phosphorylation site [posttranslational modification] 681288000449 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 681288000450 HPr interaction site; other site 681288000451 glycerol kinase (GK) interaction site [polypeptide binding]; other site 681288000452 active site 681288000453 phosphorylation site [posttranslational modification] 681288000454 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 681288000455 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 681288000456 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 681288000457 putative active site [active] 681288000458 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 681288000459 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 681288000460 active site turn [active] 681288000461 phosphorylation site [posttranslational modification] 681288000462 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 681288000463 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 681288000464 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 681288000465 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 681288000466 putative active site [active] 681288000467 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 681288000468 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 681288000469 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 681288000470 ATP binding site [chemical binding]; other site 681288000471 putative Mg++ binding site [ion binding]; other site 681288000472 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 681288000473 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 681288000474 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 681288000475 FtsX-like permease family; Region: FtsX; cl15850 681288000476 Integral membrane protein DUF95; Region: DUF95; cl00572 681288000477 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 681288000478 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 681288000479 Walker A/P-loop; other site 681288000480 ATP binding site [chemical binding]; other site 681288000481 Q-loop/lid; other site 681288000482 ABC transporter signature motif; other site 681288000483 Walker B; other site 681288000484 D-loop; other site 681288000485 H-loop/switch region; other site 681288000486 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 681288000487 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 681288000488 Walker A/P-loop; other site 681288000489 ATP binding site [chemical binding]; other site 681288000490 Q-loop/lid; other site 681288000491 ABC transporter signature motif; other site 681288000492 Walker B; other site 681288000493 D-loop; other site 681288000494 H-loop/switch region; other site 681288000495 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 681288000496 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 681288000497 Walker A/P-loop; other site 681288000498 ATP binding site [chemical binding]; other site 681288000499 Q-loop/lid; other site 681288000500 ABC transporter signature motif; other site 681288000501 Walker B; other site 681288000502 D-loop; other site 681288000503 H-loop/switch region; other site 681288000504 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 681288000505 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288000506 dimer interface [polypeptide binding]; other site 681288000507 conserved gate region; other site 681288000508 putative PBP binding loops; other site 681288000509 ABC-ATPase subunit interface; other site 681288000510 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 681288000511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288000512 dimer interface [polypeptide binding]; other site 681288000513 conserved gate region; other site 681288000514 ABC-ATPase subunit interface; other site 681288000515 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 681288000516 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 681288000517 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 681288000518 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 681288000519 Protein of unknown function, DUF576; Region: DUF576; cl04553 681288000520 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 681288000521 Peptidase family M23; Region: Peptidase_M23; pfam01551 681288000522 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 681288000523 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 681288000524 Walker A/P-loop; other site 681288000525 ATP binding site [chemical binding]; other site 681288000526 Q-loop/lid; other site 681288000527 ABC transporter signature motif; other site 681288000528 Walker B; other site 681288000529 D-loop; other site 681288000530 H-loop/switch region; other site 681288000531 TOBE domain; Region: TOBE_2; cl01440 681288000532 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 681288000533 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 681288000534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288000535 dimer interface [polypeptide binding]; other site 681288000536 conserved gate region; other site 681288000537 ABC-ATPase subunit interface; other site 681288000538 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 681288000539 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288000540 dimer interface [polypeptide binding]; other site 681288000541 conserved gate region; other site 681288000542 putative PBP binding loops; other site 681288000543 ABC-ATPase subunit interface; other site 681288000544 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 681288000545 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288000546 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 681288000547 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 681288000548 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288000549 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 681288000550 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 681288000551 Phospholipid methyltransferase; Region: PEMT; cl00763 681288000552 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 681288000553 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288000554 putative substrate translocation pore; other site 681288000555 Response regulator receiver domain; Region: Response_reg; pfam00072 681288000556 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 681288000557 active site 681288000558 phosphorylation site [posttranslational modification] 681288000559 intermolecular recognition site; other site 681288000560 dimerization interface [polypeptide binding]; other site 681288000561 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 681288000562 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 681288000563 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 681288000564 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 681288000565 Histidine kinase; Region: His_kinase; pfam06580 681288000566 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 681288000567 ATP binding site [chemical binding]; other site 681288000568 Mg2+ binding site [ion binding]; other site 681288000569 G-X-G motif; other site 681288000570 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 681288000571 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 681288000572 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 681288000573 Pyruvate formate lyase 1; Region: PFL1; cd01678 681288000574 coenzyme A binding site [chemical binding]; other site 681288000575 active site 681288000576 catalytic residues [active] 681288000577 glycine loop; other site 681288000578 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 681288000579 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 681288000580 FeS/SAM binding site; other site 681288000581 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 681288000582 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 681288000583 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 681288000584 putative active site [active] 681288000585 catalytic site [active] 681288000586 putative metal binding site [ion binding]; other site 681288000587 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 681288000588 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 681288000589 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 681288000590 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 681288000591 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 681288000592 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 681288000593 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 681288000594 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 681288000595 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 681288000596 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 681288000597 dimer interface [polypeptide binding]; other site 681288000598 active site 681288000599 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 681288000600 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288000601 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 681288000602 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 681288000603 substrate binding site [chemical binding]; other site 681288000604 oxyanion hole (OAH) forming residues; other site 681288000605 trimer interface [polypeptide binding]; other site 681288000606 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 681288000607 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 681288000608 active site 681288000609 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 681288000610 AMP-binding enzyme; Region: AMP-binding; cl15778 681288000611 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 681288000612 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 681288000613 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 681288000614 Protease prsW family; Region: PrsW-protease; cl15823 681288000615 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 681288000616 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 681288000617 Protein of unknown function, DUF488; Region: DUF488; cl01246 681288000618 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 681288000619 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 681288000620 heme-binding site [chemical binding]; other site 681288000621 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 681288000622 FAD binding pocket [chemical binding]; other site 681288000623 FAD binding motif [chemical binding]; other site 681288000624 phosphate binding motif [ion binding]; other site 681288000625 beta-alpha-beta structure motif; other site 681288000626 NAD binding pocket [chemical binding]; other site 681288000627 Heme binding pocket [chemical binding]; other site 681288000628 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 681288000629 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 681288000630 tetramer (dimer of dimers) interface [polypeptide binding]; other site 681288000631 NAD binding site [chemical binding]; other site 681288000632 dimer interface [polypeptide binding]; other site 681288000633 substrate binding site [chemical binding]; other site 681288000634 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 681288000635 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 681288000636 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 681288000637 active site turn [active] 681288000638 phosphorylation site [posttranslational modification] 681288000639 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 681288000640 active site 681288000641 tetramer interface [polypeptide binding]; other site 681288000642 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 681288000643 Helix-turn-helix domains; Region: HTH; cl00088 681288000644 PRD domain; Region: PRD; cl15445 681288000645 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 681288000646 active site 681288000647 P-loop; other site 681288000648 phosphorylation site [posttranslational modification] 681288000649 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 681288000650 active site 681288000651 phosphorylation site [posttranslational modification] 681288000652 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 681288000653 active site 681288000654 phosphorylation site [posttranslational modification] 681288000655 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 681288000656 active site 681288000657 P-loop; other site 681288000658 phosphorylation site [posttranslational modification] 681288000659 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 681288000660 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 681288000661 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 681288000662 putative NAD(P) binding site [chemical binding]; other site 681288000663 catalytic Zn binding site [ion binding]; other site 681288000664 structural Zn binding site [ion binding]; other site 681288000665 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 681288000666 substrate binding site; other site 681288000667 dimer interface; other site 681288000668 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 681288000669 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 681288000670 putative NAD(P) binding site [chemical binding]; other site 681288000671 putative catalytic Zn binding site [ion binding]; other site 681288000672 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 681288000673 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 681288000674 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 681288000675 substrate binding site; other site 681288000676 dimer interface; other site 681288000677 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 681288000678 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 681288000679 putative NAD(P) binding site [chemical binding]; other site 681288000680 putative catalytic Zn binding site [ion binding]; other site 681288000681 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 681288000682 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 681288000683 active site 681288000684 cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276 681288000685 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 681288000686 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 681288000687 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 681288000688 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 681288000689 Histidine kinase; Region: His_kinase; pfam06580 681288000690 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 681288000691 two-component response regulator; Provisional; Region: PRK14084 681288000692 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 681288000693 active site 681288000694 phosphorylation site [posttranslational modification] 681288000695 intermolecular recognition site; other site 681288000696 dimerization interface [polypeptide binding]; other site 681288000697 LytTr DNA-binding domain; Region: LytTR; cl04498 681288000698 LrgA family; Region: LrgA; cl00608 681288000699 LrgB-like family; Region: LrgB; cl00596 681288000700 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 681288000701 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 681288000702 DNA-binding site [nucleotide binding]; DNA binding site 681288000703 UTRA domain; Region: UTRA; cl01230 681288000704 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 681288000705 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 681288000706 HPr interaction site; other site 681288000707 glycerol kinase (GK) interaction site [polypeptide binding]; other site 681288000708 active site 681288000709 phosphorylation site [posttranslational modification] 681288000710 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 681288000711 Methyltransferase domain; Region: Methyltransf_31; pfam13847 681288000712 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 681288000713 S-adenosylmethionine binding site [chemical binding]; other site 681288000714 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 681288000715 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 681288000716 substrate binding site [chemical binding]; other site 681288000717 dimer interface [polypeptide binding]; other site 681288000718 ATP binding site [chemical binding]; other site 681288000719 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 681288000720 Sugar transport protein; Region: Sugar_transport; pfam06800 681288000721 Transcriptional regulators [Transcription]; Region: PurR; COG1609 681288000722 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 681288000723 DNA binding site [nucleotide binding] 681288000724 domain linker motif; other site 681288000725 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 681288000726 dimerization interface [polypeptide binding]; other site 681288000727 ligand binding site [chemical binding]; other site 681288000728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 681288000729 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288000730 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 681288000731 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 681288000732 active site 681288000733 Surface antigen [General function prediction only]; Region: COG3942 681288000734 Peptidase family M23; Region: Peptidase_M23; pfam01551 681288000735 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288000736 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 681288000737 Walker A/P-loop; other site 681288000738 ATP binding site [chemical binding]; other site 681288000739 Q-loop/lid; other site 681288000740 ABC transporter signature motif; other site 681288000741 Walker B; other site 681288000742 D-loop; other site 681288000743 H-loop/switch region; other site 681288000744 Surface antigen [General function prediction only]; Region: COG3942 681288000745 NlpC/P60 family; Region: NLPC_P60; cl11438 681288000746 Proteins of 100 residues with WXG; Region: WXG100; cl02005 681288000747 Predicted membrane protein [Function unknown]; Region: COG1511 681288000748 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 681288000749 ABC-2 type transporter; Region: ABC2_membrane; cl11417 681288000750 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 681288000751 Ubiquitin-like proteins; Region: UBQ; cl00155 681288000752 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 681288000753 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 681288000754 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 681288000755 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288000756 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288000757 Proteins of 100 residues with WXG; Region: WXG100; cl02005 681288000758 Uncharacterized conserved protein [Function unknown]; Region: COG5444 681288000759 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 681288000760 Protein of unknown function, DUF600; Region: DUF600; cl04640 681288000761 Protein of unknown function, DUF600; Region: DUF600; cl04640 681288000762 Protein of unknown function, DUF600; Region: DUF600; cl04640 681288000763 Protein of unknown function, DUF600; Region: DUF600; cl04640 681288000764 Protein of unknown function, DUF600; Region: DUF600; cl04640 681288000765 Protein of unknown function, DUF600; Region: DUF600; cl04640 681288000766 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 681288000767 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 681288000768 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 681288000769 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 681288000770 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 681288000771 FtsX-like permease family; Region: FtsX; cl15850 681288000772 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 681288000773 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 681288000774 Walker A/P-loop; other site 681288000775 ATP binding site [chemical binding]; other site 681288000776 Q-loop/lid; other site 681288000777 ABC transporter signature motif; other site 681288000778 Walker B; other site 681288000779 D-loop; other site 681288000780 H-loop/switch region; other site 681288000781 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 681288000782 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 681288000783 putative kinase; Provisional; Region: PRK09954 681288000784 Helix-turn-helix domains; Region: HTH; cl00088 681288000785 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 681288000786 substrate binding site [chemical binding]; other site 681288000787 ATP binding site [chemical binding]; other site 681288000788 Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983 681288000789 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 681288000790 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 681288000791 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 681288000792 Sodium:solute symporter family; Region: SSF; cl00456 681288000793 putative transporter; Provisional; Region: PRK10484 681288000794 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 681288000795 N-acetylneuraminate lyase; Region: nanA; TIGR00683 681288000796 inhibitor site; inhibition site 681288000797 active site 681288000798 dimer interface [polypeptide binding]; other site 681288000799 catalytic residue [active] 681288000800 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 681288000801 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 681288000802 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 681288000803 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 681288000804 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 681288000805 putative active site [active] 681288000806 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 681288000807 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 681288000808 putative active site cavity [active] 681288000809 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 681288000810 Nucleoside recognition; Region: Gate; cl00486 681288000811 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 681288000812 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 681288000813 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 681288000814 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 681288000815 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 681288000816 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 681288000817 putative active site [active] 681288000818 putative FMN binding site [chemical binding]; other site 681288000819 putative substrate binding site [chemical binding]; other site 681288000820 putative catalytic residue [active] 681288000821 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 681288000822 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 681288000823 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 681288000824 lipoyl attachment site [posttranslational modification]; other site 681288000825 Helix-turn-helix domains; Region: HTH; cl00088 681288000826 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 681288000827 putative ADP-ribose binding site [chemical binding]; other site 681288000828 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cd00296 681288000829 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 681288000830 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 681288000831 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 681288000832 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 681288000833 cinnamyl-alcohol dehydrogenase family protein; Region: PLN02662 681288000834 NADP binding site [chemical binding]; other site 681288000835 putative substrate binding site [chemical binding]; other site 681288000836 active site 681288000837 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 681288000838 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 681288000839 active site 681288000840 P-loop; other site 681288000841 phosphorylation site [posttranslational modification] 681288000842 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 681288000843 active site 681288000844 phosphorylation site [posttranslational modification] 681288000845 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 681288000846 Helix-turn-helix domains; Region: HTH; cl00088 681288000847 Helix-turn-helix domains; Region: HTH; cl00088 681288000848 PRD domain; Region: PRD; cl15445 681288000849 PRD domain; Region: PRD; cl15445 681288000850 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 681288000851 active site 681288000852 P-loop; other site 681288000853 phosphorylation site [posttranslational modification] 681288000854 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 681288000855 active site 681288000856 phosphorylation site [posttranslational modification] 681288000857 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 681288000858 Helix-turn-helix domains; Region: HTH; cl00088 681288000859 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 681288000860 MatE; Region: MatE; cl10513 681288000861 MatE; Region: MatE; cl10513 681288000862 MepB protein; Region: MepB; cl01985 681288000863 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 681288000864 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288000865 putative substrate translocation pore; other site 681288000866 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288000867 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 681288000868 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 681288000869 Zn binding site [ion binding]; other site 681288000870 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 681288000871 Zn binding site [ion binding]; other site 681288000872 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 681288000873 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 681288000874 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 681288000875 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 681288000876 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 681288000877 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 681288000878 Imelysin; Region: Peptidase_M75; cl09159 681288000879 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 681288000880 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 681288000881 Iron permease FTR1 family; Region: FTR1; cl00475 681288000882 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 681288000883 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 681288000884 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 681288000885 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 681288000886 non-specific DNA binding site [nucleotide binding]; other site 681288000887 salt bridge; other site 681288000888 sequence-specific DNA binding site [nucleotide binding]; other site 681288000889 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 681288000890 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 681288000891 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 681288000892 Walker A/P-loop; other site 681288000893 ATP binding site [chemical binding]; other site 681288000894 Q-loop/lid; other site 681288000895 ABC transporter signature motif; other site 681288000896 Walker B; other site 681288000897 D-loop; other site 681288000898 H-loop/switch region; other site 681288000899 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 681288000900 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 681288000901 putative acyltransferase; Provisional; Region: PRK05790 681288000902 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 681288000903 dimer interface [polypeptide binding]; other site 681288000904 active site 681288000905 Putative cyclase; Region: Cyclase; cl00814 681288000906 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 681288000907 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371 681288000908 THF binding site; other site 681288000909 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 681288000910 substrate binding site [chemical binding]; other site 681288000911 THF binding site; other site 681288000912 zinc-binding site [ion binding]; other site 681288000913 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 681288000914 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 681288000915 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 681288000916 FAD binding site [chemical binding]; other site 681288000917 cystathionine beta-lyase; Provisional; Region: PRK08064 681288000918 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 681288000919 homodimer interface [polypeptide binding]; other site 681288000920 substrate-cofactor binding pocket; other site 681288000921 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288000922 catalytic residue [active] 681288000923 cystathionine gamma-synthase; Reviewed; Region: PRK08247 681288000924 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 681288000925 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 681288000926 catalytic residue [active] 681288000927 ParB-like partition proteins; Region: parB_part; TIGR00180 681288000928 ParB-like nuclease domain; Region: ParBc; cl02129 681288000929 Mechanosensitive ion channel; Region: MS_channel; pfam00924 681288000930 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 681288000931 GTP-binding protein YchF; Reviewed; Region: PRK09601 681288000932 YchF GTPase; Region: YchF; cd01900 681288000933 G1 box; other site 681288000934 GTP/Mg2+ binding site [chemical binding]; other site 681288000935 Switch I region; other site 681288000936 G2 box; other site 681288000937 Switch II region; other site 681288000938 G3 box; other site 681288000939 G4 box; other site 681288000940 G5 box; other site 681288000941 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 681288000942 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 681288000943 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 681288000944 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 681288000945 dimer interface [polypeptide binding]; other site 681288000946 ssDNA binding site [nucleotide binding]; other site 681288000947 tetramer (dimer of dimers) interface [polypeptide binding]; other site 681288000948 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 681288000949 Abi-like protein; Region: Abi_2; cl01988 681288000950 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 681288000951 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288000952 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 681288000953 Predicted membrane protein [Function unknown]; Region: COG3212 681288000954 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 681288000955 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 681288000956 non-specific DNA binding site [nucleotide binding]; other site 681288000957 salt bridge; other site 681288000958 sequence-specific DNA binding site [nucleotide binding]; other site 681288000959 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 681288000960 catalytic core [active] 681288000961 extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502 681288000962 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 681288000963 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 681288000964 catalytic residue [active] 681288000965 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 681288000966 catalytic residues [active] 681288000967 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288000968 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 681288000969 peroxiredoxin; Region: AhpC; TIGR03137 681288000970 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 681288000971 dimer interface [polypeptide binding]; other site 681288000972 decamer (pentamer of dimers) interface [polypeptide binding]; other site 681288000973 catalytic triad [active] 681288000974 peroxidatic and resolving cysteines [active] 681288000975 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 681288000976 dimer interface [polypeptide binding]; other site 681288000977 FMN binding site [chemical binding]; other site 681288000978 NADPH bind site [chemical binding]; other site 681288000979 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 681288000980 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 681288000982 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 681288000983 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 681288000984 active site 681288000985 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 681288000986 xanthine permease; Region: pbuX; TIGR03173 681288000987 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 681288000988 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 681288000989 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 681288000990 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 681288000991 active site 681288000992 GMP synthase; Reviewed; Region: guaA; PRK00074 681288000993 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 681288000994 AMP/PPi binding site [chemical binding]; other site 681288000995 candidate oxyanion hole; other site 681288000996 catalytic triad [active] 681288000997 potential glutamine specificity residues [chemical binding]; other site 681288000998 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 681288000999 ATP Binding subdomain [chemical binding]; other site 681288001000 Ligand Binding sites [chemical binding]; other site 681288001001 Dimerization subdomain; other site 681288001002 PemK-like protein; Region: PemK; cl00995 681288001003 Helix-turn-helix domains; Region: HTH; cl00088 681288001004 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 681288001005 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 681288001006 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 681288001007 NADP binding site [chemical binding]; other site 681288001008 superantigen-like protein; Reviewed; Region: PRK13037 681288001009 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 681288001010 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288001011 superantigen-like protein; Reviewed; Region: PRK13041 681288001012 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 681288001013 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288001014 superantigen-like protein; Reviewed; Region: PRK13335 681288001015 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 681288001016 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288001017 superantigen-like protein; Reviewed; Region: PRK13042 681288001018 Mucin-like glycoprotein; Region: Mucin; pfam01456 681288001019 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 681288001020 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288001021 superantigen-like protein 5; Reviewed; Region: PRK13035 681288001022 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 681288001023 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288001024 superantigen-like protein 7; Reviewed; Region: PRK13346 681288001025 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 681288001026 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288001027 superantigen-like protein; Reviewed; Region: PRK13039 681288001028 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 681288001029 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288001030 superantigen-like protein; Reviewed; Region: PRK13345 681288001031 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 681288001032 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288001033 superantigen-like protein 5; Reviewed; Region: PRK13035 681288001034 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 681288001035 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288001036 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 681288001037 HsdM N-terminal domain; Region: HsdM_N; pfam12161 681288001038 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288001039 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 681288001040 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 681288001041 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 681288001042 superantigen-like protein; Reviewed; Region: PRK13036 681288001043 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 681288001044 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288001045 Protein of unknown function, DUF576; Region: DUF576; cl04553 681288001046 Protein of unknown function, DUF576; Region: DUF576; cl04553 681288001047 Protein of unknown function, DUF576; Region: DUF576; cl04553 681288001048 Protein of unknown function, DUF576; Region: DUF576; cl04553 681288001049 Protein of unknown function, DUF576; Region: DUF576; cl04553 681288001050 Protein of unknown function, DUF576; Region: DUF576; cl04553 681288001051 Protein of unknown function, DUF576; Region: DUF576; cl04553 681288001052 Protein of unknown function, DUF576; Region: DUF576; cl04553 681288001053 Protein of unknown function, DUF576; Region: DUF576; cl04553 681288001054 Protein of unknown function, DUF576; Region: DUF576; cl04553 681288001055 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 681288001056 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288001057 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 681288001058 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 681288001059 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 681288001060 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 681288001061 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 681288001062 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 681288001063 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 681288001064 active site 681288001065 Esterase/lipase [General function prediction only]; Region: COG1647 681288001066 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 681288001067 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 681288001068 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 681288001069 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 681288001070 dimer interface [polypeptide binding]; other site 681288001071 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288001072 catalytic residue [active] 681288001073 cystathionine beta-lyase; Provisional; Region: PRK07671 681288001074 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 681288001075 homodimer interface [polypeptide binding]; other site 681288001076 substrate-cofactor binding pocket; other site 681288001077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288001078 catalytic residue [active] 681288001079 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 681288001080 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 681288001081 Walker A/P-loop; other site 681288001082 ATP binding site [chemical binding]; other site 681288001083 Q-loop/lid; other site 681288001084 ABC transporter signature motif; other site 681288001085 Walker B; other site 681288001086 D-loop; other site 681288001087 H-loop/switch region; other site 681288001088 NIL domain; Region: NIL; cl09633 681288001089 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288001090 dimer interface [polypeptide binding]; other site 681288001091 conserved gate region; other site 681288001092 ABC-ATPase subunit interface; other site 681288001093 NMT1-like family; Region: NMT1_2; cl15260 681288001094 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 681288001095 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 681288001096 putative peptidoglycan binding site; other site 681288001097 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 681288001098 putative peptidoglycan binding site; other site 681288001099 NlpC/P60 family; Region: NLPC_P60; cl11438 681288001100 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 681288001101 nudix motif; other site 681288001102 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 681288001103 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 681288001104 YibE/F-like protein; Region: YibE_F; cl02259 681288001105 YibE/F-like protein; Region: YibE_F; cl02259 681288001106 Helix-turn-helix domains; Region: HTH; cl00088 681288001107 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 681288001108 dimerization interface [polypeptide binding]; other site 681288001109 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 681288001110 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 681288001111 active site 681288001112 dimer interface [polypeptide binding]; other site 681288001113 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 681288001114 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 681288001115 active site 681288001116 FMN binding site [chemical binding]; other site 681288001117 substrate binding site [chemical binding]; other site 681288001118 3Fe-4S cluster binding site [ion binding]; other site 681288001119 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 681288001120 domain interface; other site 681288001121 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 681288001122 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288001123 NAD(P) binding site [chemical binding]; other site 681288001124 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 681288001125 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 681288001126 active site turn [active] 681288001127 phosphorylation site [posttranslational modification] 681288001128 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 681288001129 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 681288001130 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 681288001131 Ca binding site [ion binding]; other site 681288001132 active site 681288001133 catalytic site [active] 681288001134 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 681288001135 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 681288001136 DNA-binding site [nucleotide binding]; DNA binding site 681288001137 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 681288001138 UTRA domain; Region: UTRA; cl01230 681288001139 Predicted acetyltransferase [General function prediction only]; Region: COG3153 681288001140 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 681288001141 Coenzyme A binding pocket [chemical binding]; other site 681288001142 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 681288001143 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 681288001144 Walker A motif; other site 681288001145 ATP binding site [chemical binding]; other site 681288001146 Walker B motif; other site 681288001147 arginine finger; other site 681288001148 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 681288001149 recombination protein RecR; Reviewed; Region: recR; PRK00076 681288001150 Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278 681288001151 RecR protein; Region: RecR; pfam02132 681288001152 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 681288001153 putative active site [active] 681288001154 putative metal-binding site [ion binding]; other site 681288001155 tetramer interface [polypeptide binding]; other site 681288001156 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 681288001157 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 681288001158 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 681288001159 catalytic residue [active] 681288001160 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 681288001161 thymidylate kinase; Validated; Region: tmk; PRK00698 681288001162 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 681288001163 TMP-binding site; other site 681288001164 ATP-binding site [chemical binding]; other site 681288001165 Nitrogen regulatory protein P-II; Region: P-II; cl00412 681288001166 DNA polymerase III subunit delta'; Validated; Region: PRK08058 681288001167 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288001168 PSP1 C-terminal conserved region; Region: PSP1; cl00770 681288001169 TSC-22/dip/bun family; Region: TSC22; cl01853 681288001170 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 681288001171 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288001172 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 681288001173 GIY-YIG motif/motif A; other site 681288001174 putative active site [active] 681288001175 putative metal binding site [ion binding]; other site 681288001176 Predicted methyltransferases [General function prediction only]; Region: COG0313 681288001177 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 681288001178 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 681288001179 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 681288001180 active site 681288001181 HIGH motif; other site 681288001182 KMSKS motif; other site 681288001183 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 681288001184 tRNA binding surface [nucleotide binding]; other site 681288001185 anticodon binding site; other site 681288001186 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 681288001187 dimer interface [polypeptide binding]; other site 681288001188 putative tRNA-binding site [nucleotide binding]; other site 681288001189 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 681288001190 active site 681288001191 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 681288001192 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 681288001193 putative active site [active] 681288001194 putative metal binding site [ion binding]; other site 681288001195 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 681288001196 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288001197 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 681288001198 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 681288001199 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 681288001200 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 681288001201 pur operon repressor; Provisional; Region: PRK09213 681288001202 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 681288001203 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 681288001204 active site 681288001205 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 681288001206 homotrimer interaction site [polypeptide binding]; other site 681288001207 putative active site [active] 681288001208 SpoVG; Region: SpoVG; cl00915 681288001209 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 681288001210 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 681288001211 Substrate binding site; other site 681288001212 Mg++ binding site; other site 681288001213 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 681288001214 active site 681288001215 substrate binding site [chemical binding]; other site 681288001216 CoA binding site [chemical binding]; other site 681288001217 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 681288001218 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 681288001219 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 681288001220 active site 681288001221 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 681288001222 5S rRNA interface [nucleotide binding]; other site 681288001223 CTC domain interface [polypeptide binding]; other site 681288001224 L16 interface [polypeptide binding]; other site 681288001225 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 681288001226 putative active site [active] 681288001227 catalytic residue [active] 681288001228 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 681288001229 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 681288001230 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 681288001231 ATP binding site [chemical binding]; other site 681288001232 putative Mg++ binding site [ion binding]; other site 681288001233 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 681288001234 nucleotide binding region [chemical binding]; other site 681288001235 ATP-binding site [chemical binding]; other site 681288001236 TRCF domain; Region: TRCF; cl04088 681288001237 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 681288001238 MatE; Region: MatE; cl10513 681288001239 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 681288001240 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 681288001241 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 681288001242 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 681288001243 Septum formation initiator; Region: DivIC; cl11433 681288001244 hypothetical protein; Provisional; Region: PRK08582 681288001245 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 681288001246 RNA binding site [nucleotide binding]; other site 681288001247 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 681288001248 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 681288001249 Ligand Binding Site [chemical binding]; other site 681288001250 B3/4 domain; Region: B3_4; cl11458 681288001251 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 681288001252 active site 681288001253 FtsH Extracellular; Region: FtsH_ext; pfam06480 681288001254 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 681288001255 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 681288001256 Walker A motif; other site 681288001257 ATP binding site [chemical binding]; other site 681288001258 Walker B motif; other site 681288001259 arginine finger; other site 681288001260 Peptidase family M41; Region: Peptidase_M41; pfam01434 681288001261 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 681288001262 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 681288001263 dimerization interface [polypeptide binding]; other site 681288001264 domain crossover interface; other site 681288001265 redox-dependent activation switch; other site 681288001266 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 681288001267 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 681288001268 dimer interface [polypeptide binding]; other site 681288001269 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288001270 catalytic residue [active] 681288001271 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 681288001272 dihydropteroate synthase; Region: DHPS; TIGR01496 681288001273 substrate binding pocket [chemical binding]; other site 681288001274 dimer interface [polypeptide binding]; other site 681288001275 inhibitor binding site; inhibition site 681288001276 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 681288001277 homooctamer interface [polypeptide binding]; other site 681288001278 active site 681288001279 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 681288001280 catalytic center binding site [active] 681288001281 ATP binding site [chemical binding]; other site 681288001282 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 681288001283 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 681288001284 dimer interface [polypeptide binding]; other site 681288001285 putative anticodon binding site; other site 681288001286 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 681288001287 motif 1; other site 681288001288 active site 681288001289 motif 2; other site 681288001290 motif 3; other site 681288001291 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 681288001292 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 681288001293 DNA-binding site [nucleotide binding]; DNA binding site 681288001294 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 681288001295 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288001296 homodimer interface [polypeptide binding]; other site 681288001297 catalytic residue [active] 681288001298 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 681288001299 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 681288001300 active site 681288001301 multimer interface [polypeptide binding]; other site 681288001302 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 681288001303 predicted active site [active] 681288001304 catalytic triad [active] 681288001305 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 681288001306 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 681288001307 Nucleoside recognition; Region: Gate; cl00486 681288001308 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 681288001309 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 681288001310 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 681288001311 UvrB/uvrC motif; Region: UVR; pfam02151 681288001312 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 681288001313 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 681288001314 ADP binding site [chemical binding]; other site 681288001315 phosphagen binding site; other site 681288001316 substrate specificity loop; other site 681288001317 Clp protease ATP binding subunit; Region: clpC; CHL00095 681288001318 Clp amino terminal domain; Region: Clp_N; pfam02861 681288001319 Clp amino terminal domain; Region: Clp_N; pfam02861 681288001320 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 681288001321 Walker A motif; other site 681288001322 ATP binding site [chemical binding]; other site 681288001323 Walker B motif; other site 681288001324 arginine finger; other site 681288001325 UvrB/uvrC motif; Region: UVR; pfam02151 681288001326 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 681288001327 Walker A motif; other site 681288001328 ATP binding site [chemical binding]; other site 681288001329 Walker B motif; other site 681288001330 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 681288001331 DNA repair protein RadA; Provisional; Region: PRK11823 681288001332 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 681288001333 Walker A motif/ATP binding site; other site 681288001334 ATP binding site [chemical binding]; other site 681288001335 Walker B motif; other site 681288001336 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 681288001337 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 681288001338 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 681288001339 putative active site [active] 681288001340 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 681288001341 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 681288001342 active site 681288001343 HIGH motif; other site 681288001344 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 681288001345 active site 681288001346 KMSKS motif; other site 681288001347 serine O-acetyltransferase; Region: cysE; TIGR01172 681288001348 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 681288001349 trimer interface [polypeptide binding]; other site 681288001350 active site 681288001351 substrate binding site [chemical binding]; other site 681288001352 CoA binding site [chemical binding]; other site 681288001353 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 681288001354 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 681288001355 active site 681288001356 HIGH motif; other site 681288001357 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 681288001358 KMSKS motif; other site 681288001359 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 681288001360 tRNA binding surface [nucleotide binding]; other site 681288001361 anticodon binding site; other site 681288001362 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 681288001363 active site 681288001364 dimerization interface [polypeptide binding]; other site 681288001365 metal binding site [ion binding]; metal-binding site 681288001366 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 681288001367 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 681288001368 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 681288001369 YacP-like NYN domain; Region: NYN_YacP; cl01491 681288001370 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 681288001371 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 681288001372 Helix-turn-helix domains; Region: HTH; cl00088 681288001373 DNA binding residues [nucleotide binding] 681288001374 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 681288001375 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 681288001376 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 681288001377 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 681288001378 putative homodimer interface [polypeptide binding]; other site 681288001379 KOW motif; Region: KOW; cl00354 681288001380 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 681288001381 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 681288001382 23S rRNA interface [nucleotide binding]; other site 681288001383 L7/L12 interface [polypeptide binding]; other site 681288001384 putative thiostrepton binding site; other site 681288001385 L25 interface [polypeptide binding]; other site 681288001386 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 681288001387 mRNA/rRNA interface [nucleotide binding]; other site 681288001388 SAAV_0501 681288001389 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 681288001390 23S rRNA interface [nucleotide binding]; other site 681288001391 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 681288001392 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 681288001393 peripheral dimer interface [polypeptide binding]; other site 681288001394 core dimer interface [polypeptide binding]; other site 681288001395 L10 interface [polypeptide binding]; other site 681288001396 L11 interface [polypeptide binding]; other site 681288001397 putative EF-Tu interaction site [polypeptide binding]; other site 681288001398 putative EF-G interaction site [polypeptide binding]; other site 681288001399 Methyltransferase domain; Region: Methyltransf_31; pfam13847 681288001400 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 681288001401 S-adenosylmethionine binding site [chemical binding]; other site 681288001402 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 681288001403 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 681288001404 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 681288001405 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 681288001406 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 681288001407 RPB12 interaction site [polypeptide binding]; other site 681288001408 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 681288001409 RPB10 interaction site [polypeptide binding]; other site 681288001410 RPB1 interaction site [polypeptide binding]; other site 681288001411 RPB11 interaction site [polypeptide binding]; other site 681288001412 RPB3 interaction site [polypeptide binding]; other site 681288001413 RPB12 interaction site [polypeptide binding]; other site 681288001414 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 681288001415 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 681288001416 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 681288001417 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 681288001418 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 681288001419 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 681288001420 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 681288001421 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 681288001422 G-loop; other site 681288001423 DNA binding site [nucleotide binding] 681288001424 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 681288001425 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 681288001426 S17 interaction site [polypeptide binding]; other site 681288001427 S8 interaction site; other site 681288001428 16S rRNA interaction site [nucleotide binding]; other site 681288001429 streptomycin interaction site [chemical binding]; other site 681288001430 23S rRNA interaction site [nucleotide binding]; other site 681288001431 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 681288001432 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 681288001433 elongation factor G; Reviewed; Region: PRK00007 681288001434 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 681288001435 G1 box; other site 681288001436 putative GEF interaction site [polypeptide binding]; other site 681288001437 GTP/Mg2+ binding site [chemical binding]; other site 681288001438 Switch I region; other site 681288001439 G2 box; other site 681288001440 G3 box; other site 681288001441 Switch II region; other site 681288001442 G4 box; other site 681288001443 G5 box; other site 681288001444 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 681288001445 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 681288001446 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 681288001447 elongation factor Tu; Reviewed; Region: PRK00049 681288001448 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 681288001449 G1 box; other site 681288001450 GEF interaction site [polypeptide binding]; other site 681288001451 GTP/Mg2+ binding site [chemical binding]; other site 681288001452 Switch I region; other site 681288001453 G2 box; other site 681288001454 G3 box; other site 681288001455 Switch II region; other site 681288001456 G4 box; other site 681288001457 G5 box; other site 681288001458 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 681288001459 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 681288001460 Antibiotic Binding Site [chemical binding]; other site 681288001461 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 681288001462 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 681288001463 metal binding site [ion binding]; metal-binding site 681288001464 dimer interface [polypeptide binding]; other site 681288001465 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 681288001466 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 681288001467 substrate-cofactor binding pocket; other site 681288001468 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288001469 catalytic residue [active] 681288001470 chaperone protein HchA; Provisional; Region: PRK04155 681288001471 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 681288001472 dimer interface [polypeptide binding]; other site 681288001473 metal binding site [ion binding]; metal-binding site 681288001474 potential oxyanion hole; other site 681288001475 potential catalytic triad [active] 681288001476 conserved cys residue [active] 681288001477 ribulokinase; Provisional; Region: PRK04123 681288001478 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 681288001479 putative N- and C-terminal domain interface [polypeptide binding]; other site 681288001480 putative active site [active] 681288001481 putative MgATP binding site [chemical binding]; other site 681288001482 catalytic site [active] 681288001483 metal binding site [ion binding]; metal-binding site 681288001484 carbohydrate binding site [chemical binding]; other site 681288001485 homodimer interface [polypeptide binding]; other site 681288001486 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 681288001487 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288001488 NAD(P) binding site [chemical binding]; other site 681288001489 active site 681288001490 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 681288001491 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 681288001492 homodimer interface [polypeptide binding]; other site 681288001493 substrate-cofactor binding pocket; other site 681288001494 catalytic residue [active] 681288001495 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 681288001496 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 681288001497 motif II; other site 681288001498 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 681288001499 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 681288001500 Substrate-binding site [chemical binding]; other site 681288001501 Substrate specificity [chemical binding]; other site 681288001502 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 681288001503 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 681288001504 Substrate-binding site [chemical binding]; other site 681288001505 Substrate specificity [chemical binding]; other site 681288001506 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 681288001507 nucleoside/Zn binding site; other site 681288001508 dimer interface [polypeptide binding]; other site 681288001509 catalytic motif [active] 681288001510 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 681288001511 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 681288001512 active site 681288001513 motif I; other site 681288001514 motif II; other site 681288001515 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 681288001516 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 681288001517 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 681288001518 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 681288001519 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 681288001520 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 681288001521 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 681288001522 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 681288001523 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 681288001524 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 681288001525 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 681288001526 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 681288001527 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 681288001528 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 681288001529 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 681288001530 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 681288001531 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 681288001532 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 681288001533 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 681288001534 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 681288001535 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 681288001536 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 681288001537 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 681288001538 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 681288001539 Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642 681288001540 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 681288001541 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 681288001542 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 681288001543 active site 681288001544 trimer interface [polypeptide binding]; other site 681288001545 allosteric site; other site 681288001546 active site lid [active] 681288001547 hexamer (dimer of trimers) interface [polypeptide binding]; other site 681288001548 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 681288001549 active site 681288001550 dimer interface [polypeptide binding]; other site 681288001551 magnesium binding site [ion binding]; other site 681288001552 Predicted sugar phosphate isomerase involved in capsule formation [Cell envelope biogenesis, outer membrane]; Region: GutQ; COG0794 681288001553 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 681288001554 tetramer interface [polypeptide binding]; other site 681288001555 active site 681288001556 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 681288001557 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 681288001558 motif II; other site 681288001559 proline/glycine betaine transporter; Provisional; Region: PRK10642 681288001560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288001561 putative substrate translocation pore; other site 681288001562 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 681288001563 AMP-binding enzyme; Region: AMP-binding; cl15778 681288001564 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 681288001565 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 681288001566 dimer interface [polypeptide binding]; other site 681288001567 active site 681288001568 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 681288001569 dimer interface [polypeptide binding]; other site 681288001570 substrate binding site [chemical binding]; other site 681288001571 ATP binding site [chemical binding]; other site 681288001572 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 681288001573 ligand binding site [chemical binding]; other site 681288001574 active site 681288001575 UGI interface [polypeptide binding]; other site 681288001576 catalytic site [active] 681288001577 Protein of unknown function (DUF423); Region: DUF423; cl01008 681288001578 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 681288001579 Spore germination protein; Region: Spore_permease; cl15802 681288001580 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 681288001581 Uncharacterized conserved protein [Function unknown]; Region: COG2966 681288001582 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 681288001583 Chlorite dismutase; Region: Chlor_dismutase; cl01280 681288001584 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 681288001585 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 681288001586 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 681288001587 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 681288001588 mevalonate kinase; Region: mevalon_kin; TIGR00549 681288001589 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 681288001590 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 681288001591 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 681288001592 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 681288001593 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 681288001594 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 681288001595 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 681288001596 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 681288001597 Predicted transcriptional regulator [Transcription]; Region: COG1959 681288001598 Helix-turn-helix domains; Region: HTH; cl00088 681288001599 LXG domain of WXG superfamily; Region: LXG; pfam04740 681288001600 Protein of unknown function (DUF443); Region: DUF443; cl04467 681288001601 Protein of unknown function (DUF443); Region: DUF443; cl04467 681288001602 Protein of unknown function (DUF443); Region: DUF443; cl04467 681288001603 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 681288001604 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 681288001605 active site 681288001606 catalytic tetrad [active] 681288001607 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 681288001608 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 681288001609 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 681288001610 Coenzyme A binding pocket [chemical binding]; other site 681288001611 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 681288001612 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 681288001613 Zn2+ binding site [ion binding]; other site 681288001614 Mg2+ binding site [ion binding]; other site 681288001615 YwhD family; Region: YwhD; pfam08741 681288001616 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 681288001617 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 681288001618 NAD binding site [chemical binding]; other site 681288001619 substrate binding site [chemical binding]; other site 681288001620 catalytic Zn binding site [ion binding]; other site 681288001621 tetramer interface [polypeptide binding]; other site 681288001622 structural Zn binding site [ion binding]; other site 681288001623 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 681288001624 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 681288001625 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 681288001626 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 681288001627 active site 681288001628 HIGH motif; other site 681288001629 KMSK motif region; other site 681288001630 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 681288001631 tRNA binding surface [nucleotide binding]; other site 681288001632 anticodon binding site; other site 681288001633 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 681288001634 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 681288001635 minor groove reading motif; other site 681288001636 helix-hairpin-helix signature motif; other site 681288001637 substrate binding pocket [chemical binding]; other site 681288001638 active site 681288001639 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 681288001640 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 681288001641 putative binding site residues; other site 681288001642 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 681288001643 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 681288001644 ABC-ATPase subunit interface; other site 681288001645 dimer interface [polypeptide binding]; other site 681288001646 putative PBP binding regions; other site 681288001647 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 681288001648 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 681288001649 motif II; other site 681288001650 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 681288001651 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 681288001652 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 681288001653 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 681288001654 Helix-turn-helix domains; Region: HTH; cl00088 681288001655 Protein of unknown function, DUF606; Region: DUF606; cl01273 681288001656 Protein of unknown function, DUF606; Region: DUF606; cl01273 681288001657 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 681288001658 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 681288001659 active site 681288001660 DNA binding site [nucleotide binding] 681288001661 Int/Topo IB signature motif; other site 681288001662 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646 681288001663 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 681288001664 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 681288001665 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 681288001666 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 681288001667 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 681288001668 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 681288001669 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 681288001670 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 681288001671 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 681288001672 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 681288001673 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 681288001674 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 681288001675 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 681288001676 metal binding site [ion binding]; metal-binding site 681288001677 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 681288001678 ABC-ATPase subunit interface; other site 681288001679 dimer interface [polypeptide binding]; other site 681288001680 putative PBP binding regions; other site 681288001681 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 681288001682 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 681288001683 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 681288001684 Helix-turn-helix domains; Region: HTH; cl00088 681288001685 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 681288001686 FeoA domain; Region: FeoA; cl00838 681288001687 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 681288001688 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 681288001689 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 681288001690 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 681288001691 Walker A/P-loop; other site 681288001692 ATP binding site [chemical binding]; other site 681288001693 Q-loop/lid; other site 681288001694 ABC transporter signature motif; other site 681288001695 Walker B; other site 681288001696 D-loop; other site 681288001697 H-loop/switch region; other site 681288001698 ABC-2 type transporter; Region: ABC2_membrane; cl11417 681288001699 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 681288001700 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 681288001701 active site 681288001702 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 681288001703 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 681288001704 active site 681288001705 nucleotide binding site [chemical binding]; other site 681288001706 HIGH motif; other site 681288001707 KMSKS motif; other site 681288001708 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 681288001709 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 681288001710 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 681288001711 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 681288001712 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 681288001713 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288001714 Walker A/P-loop; other site 681288001715 ATP binding site [chemical binding]; other site 681288001716 Q-loop/lid; other site 681288001717 ABC transporter signature motif; other site 681288001718 Walker B; other site 681288001719 D-loop; other site 681288001720 H-loop/switch region; other site 681288001721 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 681288001722 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 681288001723 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 681288001724 Uncharacterized conserved protein [Function unknown]; Region: COG1284 681288001725 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 681288001726 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 681288001727 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 681288001728 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 681288001729 Walker A/P-loop; other site 681288001730 ATP binding site [chemical binding]; other site 681288001731 Q-loop/lid; other site 681288001732 ABC transporter signature motif; other site 681288001733 Walker B; other site 681288001734 D-loop; other site 681288001735 H-loop/switch region; other site 681288001736 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 681288001737 ABC-ATPase subunit interface; other site 681288001738 dimer interface [polypeptide binding]; other site 681288001739 putative PBP binding regions; other site 681288001740 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 681288001741 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 681288001742 ABC-ATPase subunit interface; other site 681288001743 dimer interface [polypeptide binding]; other site 681288001744 putative PBP binding regions; other site 681288001745 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 681288001746 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 681288001747 DAK2 domain; Region: Dak2; cl03685 681288001748 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 681288001749 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 681288001750 Uncharacterized membrane protein [Function unknown]; Region: COG3949 681288001751 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 681288001752 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 681288001753 substrate binding pocket [chemical binding]; other site 681288001754 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 681288001755 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 681288001756 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 681288001757 Coenzyme A binding pocket [chemical binding]; other site 681288001758 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 681288001759 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288001760 NAD(P) binding site [chemical binding]; other site 681288001761 active site 681288001762 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 681288001763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 681288001764 active site 681288001765 phosphorylation site [posttranslational modification] 681288001766 intermolecular recognition site; other site 681288001767 dimerization interface [polypeptide binding]; other site 681288001768 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 681288001769 DNA binding site [nucleotide binding] 681288001770 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 681288001771 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 681288001772 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 681288001773 ATP binding site [chemical binding]; other site 681288001774 Mg2+ binding site [ion binding]; other site 681288001775 G-X-G motif; other site 681288001776 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 681288001777 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 681288001778 Walker A/P-loop; other site 681288001779 ATP binding site [chemical binding]; other site 681288001780 Q-loop/lid; other site 681288001781 ABC transporter signature motif; other site 681288001782 Walker B; other site 681288001783 D-loop; other site 681288001784 H-loop/switch region; other site 681288001785 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 681288001786 Phosphate transporter family; Region: PHO4; cl00396 681288001787 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 681288001788 putative peptidoglycan binding site; other site 681288001789 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 681288001790 putative peptidoglycan binding site; other site 681288001791 NlpC/P60 family; Region: NLPC_P60; cl11438 681288001792 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 681288001793 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 681288001794 Helix-turn-helix domains; Region: HTH; cl00088 681288001795 Transcriptional regulator; Region: Transcrip_reg; cl00361 681288001796 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 681288001797 Protein of unknown function (DUF402); Region: DUF402; cl00979 681288001798 Transcriptional regulator [Transcription]; Region: LysR; COG0583 681288001799 Helix-turn-helix domains; Region: HTH; cl00088 681288001800 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 681288001801 dimerization interface [polypeptide binding]; other site 681288001802 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288001803 sugar efflux transporter; Region: 2A0120; TIGR00899 681288001804 putative substrate translocation pore; other site 681288001805 Protein of unknown function (DUF456); Region: DUF456; cl01069 681288001806 Serine incorporator (Serinc); Region: Serinc; pfam03348 681288001807 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 681288001808 Coenzyme A binding pocket [chemical binding]; other site 681288001809 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 681288001810 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 681288001811 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 681288001812 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 681288001813 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 681288001814 Bacitracin resistance protein BacA; Region: BacA; cl00858 681288001815 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 681288001816 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 681288001817 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 681288001818 Walker A/P-loop; other site 681288001819 ATP binding site [chemical binding]; other site 681288001820 Q-loop/lid; other site 681288001821 ABC transporter signature motif; other site 681288001822 Walker B; other site 681288001823 D-loop; other site 681288001824 H-loop/switch region; other site 681288001825 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 681288001826 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 681288001827 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 681288001828 Walker A/P-loop; other site 681288001829 ATP binding site [chemical binding]; other site 681288001830 Q-loop/lid; other site 681288001831 ABC transporter signature motif; other site 681288001832 Walker B; other site 681288001833 D-loop; other site 681288001834 H-loop/switch region; other site 681288001835 Transcriptional regulators [Transcription]; Region: MarR; COG1846 681288001836 Helix-turn-helix domains; Region: HTH; cl00088 681288001837 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 681288001838 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288001839 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 681288001840 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 681288001841 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 681288001842 active site 681288001843 catalytic tetrad [active] 681288001844 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 681288001845 transmembrane helices; other site 681288001846 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 681288001847 DNA photolyase; Region: DNA_photolyase; pfam00875 681288001848 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 681288001849 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 681288001850 Domain of unknown function (DUF296); Region: DUF296; cl00720 681288001851 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288001852 putative substrate translocation pore; other site 681288001853 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 681288001854 putative deacylase active site [active] 681288001855 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 681288001856 Helix-turn-helix domains; Region: HTH; cl00088 681288001857 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 681288001858 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 681288001859 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 681288001860 putative substrate binding site [chemical binding]; other site 681288001861 putative ATP binding site [chemical binding]; other site 681288001862 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 681288001863 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 681288001864 active site 681288001865 phosphorylation site [posttranslational modification] 681288001866 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 681288001867 active site 681288001868 P-loop; other site 681288001869 phosphorylation site [posttranslational modification] 681288001870 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 681288001871 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 681288001872 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 681288001873 active site 681288001874 dimer interface [polypeptide binding]; other site 681288001875 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 681288001876 Domain of unknown function DUF21; Region: DUF21; pfam01595 681288001877 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 681288001878 Transporter associated domain; Region: CorC_HlyC; cl08393 681288001879 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 681288001880 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 681288001881 active site 681288001882 catalytic tetrad [active] 681288001883 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 681288001884 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 681288001885 Ligand binding site; other site 681288001886 Putative Catalytic site; other site 681288001887 DXD motif; other site 681288001888 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 681288001889 dimer interface [polypeptide binding]; other site 681288001890 phosphorylation site [posttranslational modification] 681288001891 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 681288001892 ATP binding site [chemical binding]; other site 681288001893 Mg2+ binding site [ion binding]; other site 681288001894 G-X-G motif; other site 681288001895 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 681288001896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 681288001897 active site 681288001898 phosphorylation site [posttranslational modification] 681288001899 intermolecular recognition site; other site 681288001900 dimerization interface [polypeptide binding]; other site 681288001901 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 681288001902 DNA binding site [nucleotide binding] 681288001903 DoxX; Region: DoxX; cl00976 681288001904 Electron transfer DM13; Region: DM13; cl02735 681288001905 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 681288001906 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 681288001907 active site 681288001908 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 681288001909 Ligand Binding Site [chemical binding]; other site 681288001910 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 681288001911 Glutamine amidotransferase class-I; Region: GATase; pfam00117 681288001912 glutamine binding [chemical binding]; other site 681288001913 catalytic triad [active] 681288001914 aminodeoxychorismate synthase; Provisional; Region: PRK07508 681288001915 chorismate binding enzyme; Region: Chorismate_bind; cl10555 681288001916 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 681288001917 substrate-cofactor binding pocket; other site 681288001918 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288001919 catalytic residue [active] 681288001920 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 681288001921 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 681288001922 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 681288001923 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 681288001924 Sulfatase; Region: Sulfatase; cl10460 681288001925 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 681288001926 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 681288001927 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 681288001928 ABC transporter; Region: ABC_tran_2; pfam12848 681288001929 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 681288001930 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 681288001931 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 681288001932 ATP binding site [chemical binding]; other site 681288001933 putative Mg++ binding site [ion binding]; other site 681288001934 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 681288001935 nucleotide binding region [chemical binding]; other site 681288001936 ATP-binding site [chemical binding]; other site 681288001937 RQC domain; Region: RQC; cl09632 681288001938 HRDC domain; Region: HRDC; cl02578 681288001939 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 681288001940 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 681288001941 Walker A/P-loop; other site 681288001942 ATP binding site [chemical binding]; other site 681288001943 Q-loop/lid; other site 681288001944 ABC transporter signature motif; other site 681288001945 Walker B; other site 681288001946 D-loop; other site 681288001947 H-loop/switch region; other site 681288001948 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288001949 dimer interface [polypeptide binding]; other site 681288001950 conserved gate region; other site 681288001951 ABC-ATPase subunit interface; other site 681288001952 NMT1-like family; Region: NMT1_2; cl15260 681288001953 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 681288001954 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 681288001955 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 681288001956 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288001957 homodimer interface [polypeptide binding]; other site 681288001958 catalytic residue [active] 681288001959 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 681288001960 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 681288001961 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 681288001962 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 681288001963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288001964 putative substrate translocation pore; other site 681288001965 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 681288001966 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 681288001967 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 681288001968 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 681288001969 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 681288001970 Class I ribonucleotide reductase; Region: RNR_I; cd01679 681288001971 active site 681288001972 dimer interface [polypeptide binding]; other site 681288001973 catalytic residues [active] 681288001974 effector binding site; other site 681288001975 R2 peptide binding site; other site 681288001976 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 681288001977 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 681288001978 dimer interface [polypeptide binding]; other site 681288001979 putative radical transfer pathway; other site 681288001980 diiron center [ion binding]; other site 681288001981 tyrosyl radical; other site 681288001982 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 681288001983 ABC-ATPase subunit interface; other site 681288001984 dimer interface [polypeptide binding]; other site 681288001985 putative PBP binding regions; other site 681288001986 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 681288001987 ABC-ATPase subunit interface; other site 681288001988 dimer interface [polypeptide binding]; other site 681288001989 putative PBP binding regions; other site 681288001990 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 681288001991 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 681288001992 Walker A/P-loop; other site 681288001993 ATP binding site [chemical binding]; other site 681288001994 Q-loop/lid; other site 681288001995 ABC transporter signature motif; other site 681288001996 Walker B; other site 681288001997 D-loop; other site 681288001998 H-loop/switch region; other site 681288001999 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 681288002000 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 681288002001 putative ligand binding residues [chemical binding]; other site 681288002002 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 681288002003 CHY zinc finger; Region: zf-CHY; pfam05495 681288002004 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906 681288002005 FAD binding domain; Region: FAD_binding_4; pfam01565 681288002006 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 681288002007 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 681288002008 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 681288002009 Glycerate kinase family; Region: Gly_kinase; cl00841 681288002010 peptidase T; Region: peptidase-T; TIGR01882 681288002011 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 681288002012 metal binding site [ion binding]; metal-binding site 681288002013 dimer interface [polypeptide binding]; other site 681288002014 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 681288002015 Uncharacterized conserved protein [Function unknown]; Region: COG2966 681288002016 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 681288002017 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 681288002018 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 681288002019 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 681288002020 metal binding site [ion binding]; metal-binding site 681288002021 active site 681288002022 I-site; other site 681288002023 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 681288002024 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 681288002025 Mg++ binding site [ion binding]; other site 681288002026 putative catalytic motif [active] 681288002027 substrate binding site [chemical binding]; other site 681288002028 Uncharacterized conserved protein [Function unknown]; Region: COG1739 681288002029 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 681288002030 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 681288002031 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 681288002032 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 681288002033 ATP binding site [chemical binding]; other site 681288002034 putative Mg++ binding site [ion binding]; other site 681288002035 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 681288002036 nucleotide binding region [chemical binding]; other site 681288002037 ATP-binding site [chemical binding]; other site 681288002038 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 681288002039 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 681288002040 active site 681288002041 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 681288002042 30S subunit binding site; other site 681288002043 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 681288002044 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 681288002045 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 681288002046 nucleotide binding region [chemical binding]; other site 681288002047 ATP-binding site [chemical binding]; other site 681288002048 SEC-C motif; Region: SEC-C; pfam02810 681288002049 peptide chain release factor 2; Provisional; Region: PRK06746 681288002050 RF-1 domain; Region: RF-1; cl02875 681288002051 RF-1 domain; Region: RF-1; cl02875 681288002052 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 681288002053 putative peptidoglycan binding site; other site 681288002054 NlpC/P60 family; Region: NLPC_P60; cl11438 681288002055 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 681288002056 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 681288002057 excinuclease ABC subunit B; Provisional; Region: PRK05298 681288002058 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 681288002059 ATP binding site [chemical binding]; other site 681288002060 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 681288002061 nucleotide binding region [chemical binding]; other site 681288002062 ATP-binding site [chemical binding]; other site 681288002063 Ultra-violet resistance protein B; Region: UvrB; pfam12344 681288002064 UvrB/uvrC motif; Region: UVR; pfam02151 681288002065 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 681288002066 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 681288002067 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 681288002068 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 681288002069 HPr kinase/phosphorylase; Provisional; Region: PRK05428 681288002070 DRTGG domain; Region: DRTGG; cl12147 681288002071 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 681288002072 Hpr binding site; other site 681288002073 active site 681288002074 homohexamer subunit interaction site [polypeptide binding]; other site 681288002075 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 681288002076 putative acyl transferase; Provisional; Region: PRK10191 681288002077 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 681288002078 trimer interface [polypeptide binding]; other site 681288002079 active site 681288002080 substrate binding site [chemical binding]; other site 681288002081 CoA binding site [chemical binding]; other site 681288002082 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 681288002083 binding surface 681288002084 TPR motif; other site 681288002085 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 681288002086 TPR motif; other site 681288002087 binding surface 681288002088 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288002089 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 681288002090 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 681288002091 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 681288002092 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 681288002093 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 681288002094 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 681288002095 phosphate binding site [ion binding]; other site 681288002096 dimer interface [polypeptide binding]; other site 681288002097 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 681288002098 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 681288002099 Clp protease; Region: CLP_protease; pfam00574 681288002100 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 681288002101 oligomer interface [polypeptide binding]; other site 681288002102 active site residues [active] 681288002103 TIGR01777 family protein; Region: yfcH 681288002104 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288002105 NAD(P) binding site [chemical binding]; other site 681288002106 active site 681288002107 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 681288002108 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 681288002109 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288002110 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 681288002111 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 681288002112 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 681288002113 Phosphoglycerate kinase; Region: PGK; pfam00162 681288002114 substrate binding site [chemical binding]; other site 681288002115 hinge regions; other site 681288002116 ADP binding site [chemical binding]; other site 681288002117 catalytic site [active] 681288002118 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 681288002119 substrate binding site [chemical binding]; other site 681288002120 dimer interface [polypeptide binding]; other site 681288002121 catalytic triad [active] 681288002122 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 681288002123 Sulfatase; Region: Sulfatase; cl10460 681288002124 enolase; Provisional; Region: eno; PRK00077 681288002125 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 681288002126 dimer interface [polypeptide binding]; other site 681288002127 metal binding site [ion binding]; metal-binding site 681288002128 substrate binding pocket [chemical binding]; other site 681288002129 Preprotein translocase SecG subunit; Region: SecG; cl09123 681288002130 Esterase/lipase [General function prediction only]; Region: COG1647 681288002131 ribonuclease R; Region: RNase_R; TIGR02063 681288002132 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 681288002133 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 681288002134 RNB domain; Region: RNB; pfam00773 681288002135 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 681288002136 RNA binding site [nucleotide binding]; other site 681288002137 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 681288002138 SmpB-tmRNA interface; other site 681288002139 Predicted acetyltransferase [General function prediction only]; Region: COG3153 681288002140 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 681288002141 Coenzyme A binding pocket [chemical binding]; other site 681288002142 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 681288002143 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 681288002144 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 681288002145 Staphylococcal nuclease homologues; Region: SNc; smart00318 681288002146 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 681288002147 Catalytic site; other site 681288002148 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 681288002149 DNA-binding site [nucleotide binding]; DNA binding site 681288002150 RNA-binding motif; other site 681288002151 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 681288002152 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 681288002153 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 681288002154 catalytic core [active] 681288002155 LysE type translocator; Region: LysE; cl00565 681288002156 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 681288002157 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 681288002158 OsmC-like protein; Region: OsmC; cl00767 681288002159 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 681288002160 active site 681288002161 3-dehydroquinate dehydratase, type I; Region: aroD; TIGR01093 681288002162 catalytic residue [active] 681288002163 dimer interface [polypeptide binding]; other site 681288002164 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 681288002165 putative FMN binding site [chemical binding]; other site 681288002166 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 681288002167 catalytic residues [active] 681288002168 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 681288002169 ArsC family; Region: ArsC; pfam03960 681288002170 putative ArsC-like catalytic residues; other site 681288002171 putative TRX-like catalytic residues [active] 681288002172 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 681288002173 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 681288002174 putative active site [active] 681288002175 putative metal binding site [ion binding]; other site 681288002176 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 681288002177 catalytic residues [active] 681288002178 SAAV_0983 681288002179 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 681288002180 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 681288002181 Walker A/P-loop; other site 681288002182 ATP binding site [chemical binding]; other site 681288002183 Q-loop/lid; other site 681288002184 ABC transporter signature motif; other site 681288002185 Walker B; other site 681288002186 D-loop; other site 681288002187 H-loop/switch region; other site 681288002188 NIL domain; Region: NIL; cl09633 681288002189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288002190 dimer interface [polypeptide binding]; other site 681288002191 conserved gate region; other site 681288002192 ABC-ATPase subunit interface; other site 681288002193 NMT1-like family; Region: NMT1_2; cl15260 681288002194 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 681288002195 Int/Topo IB signature motif; other site 681288002196 SAP domain; Region: SAP; cl02640 681288002197 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 681288002198 non-specific DNA binding site [nucleotide binding]; other site 681288002199 salt bridge; other site 681288002200 sequence-specific DNA binding site [nucleotide binding]; other site 681288002201 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 681288002202 non-specific DNA binding site [nucleotide binding]; other site 681288002203 salt bridge; other site 681288002204 sequence-specific DNA binding site [nucleotide binding]; other site 681288002205 Protein of unknown function (DUF1474); Region: DUF1474; pfam07342 681288002206 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 681288002207 Domain of unknown function (DUF927); Region: DUF927; cl12098 681288002208 Coat F domain; Region: Coat_F; cl15836 681288002209 transcriptional regulator NarP; Provisional; Region: PRK10403 681288002210 Terminase small subunit; Region: Terminase_2; cl01513 681288002211 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 681288002212 CsbD-like; Region: CsbD; cl15799 681288002213 Domain of unknown function (DUF368); Region: DUF368; cl00893 681288002214 FeS assembly ATPase SufC; Region: sufC; TIGR01978 681288002215 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 681288002216 Walker A/P-loop; other site 681288002217 ATP binding site [chemical binding]; other site 681288002218 Q-loop/lid; other site 681288002219 ABC transporter signature motif; other site 681288002220 Walker B; other site 681288002221 D-loop; other site 681288002222 H-loop/switch region; other site 681288002223 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 681288002224 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 681288002225 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 681288002226 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 681288002227 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 681288002228 catalytic residue [active] 681288002229 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 681288002230 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 681288002231 trimerization site [polypeptide binding]; other site 681288002232 active site 681288002233 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 681288002234 FeS assembly protein SufB; Region: sufB; TIGR01980 681288002235 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 681288002236 Int/Topo IB signature motif; other site 681288002237 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288002238 DpnII restriction endonuclease; Region: DpnII; pfam04556 681288002239 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288002240 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 681288002241 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 681288002242 non-specific DNA binding site [nucleotide binding]; other site 681288002243 salt bridge; other site 681288002244 sequence-specific DNA binding site [nucleotide binding]; other site 681288002245 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 681288002246 Catalytic site [active] 681288002247 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 681288002248 AntA/AntB antirepressor; Region: AntA; cl01430 681288002249 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 681288002250 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 681288002251 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 681288002252 ERF superfamily; Region: ERF; pfam04404 681288002253 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 681288002254 dimer interface [polypeptide binding]; other site 681288002255 ssDNA binding site [nucleotide binding]; other site 681288002256 tetramer (dimer of dimers) interface [polypeptide binding]; other site 681288002257 Helix-turn-helix domains; Region: HTH; cl00088 681288002258 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; cl09752 681288002259 hypothetical protein; Validated; Region: PRK08116 681288002260 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288002261 Endodeoxyribonuclease RusA; Region: RusA; cl01885 681288002262 Protein of unknown function (DUF3113); Region: DUF3113; pfam11310 681288002263 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 681288002264 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 681288002265 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 681288002266 trimer interface [polypeptide binding]; other site 681288002267 active site 681288002268 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 681288002269 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 681288002270 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 681288002271 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 681288002272 Phage terminase, small subunit; Region: Terminase_4; cl01525 681288002273 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 681288002274 Phage Terminase; Region: Terminase_1; pfam03354 681288002275 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 681288002276 Phage-related protein [Function unknown]; Region: COG4695; cl01923 681288002277 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 681288002278 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 681288002279 Phage capsid family; Region: Phage_capsid; pfam05065 681288002280 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 681288002281 oligomerization interface [polypeptide binding]; other site 681288002282 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 681288002283 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 681288002284 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 681288002285 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 681288002286 Phage-related protein [Function unknown]; Region: COG5412 681288002287 Peptidase family M23; Region: Peptidase_M23; pfam01551 681288002288 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 681288002289 N-acetyl-D-glucosamine binding site [chemical binding]; other site 681288002290 catalytic residue [active] 681288002291 Phage tail protein; Region: Sipho_tail; pfam05709 681288002292 Phage tail protein; Region: Sipho_tail; pfam05709 681288002293 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 681288002294 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 681288002295 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 681288002296 Zinc finger-containing protein; Region: zf-C4H2; pfam10146 681288002297 Ligand-gated ion channel; Region: Lig_chan; pfam00060 681288002298 Phage lysis protein, holin; Region: Phage_holin; cl04675 681288002299 NlpC/P60 family; Region: NLPC_P60; cl11438 681288002300 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 681288002301 active site 681288002302 metal binding site [ion binding]; metal-binding site 681288002303 Domain of unknown function DUF21; Region: DUF21; pfam01595 681288002304 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 681288002305 Nitronate monooxygenase; Region: NMO; pfam03060 681288002306 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 681288002307 FMN binding site [chemical binding]; other site 681288002308 substrate binding site [chemical binding]; other site 681288002309 putative catalytic residue [active] 681288002310 Protein of unknown function DUF72; Region: DUF72; cl00777 681288002311 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 681288002312 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 681288002313 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 681288002314 active site 681288002315 metal binding site [ion binding]; metal-binding site 681288002316 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 681288002317 lipoyl synthase; Provisional; Region: PRK05481 681288002318 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 681288002319 FeS/SAM binding site; other site 681288002320 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 681288002321 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 681288002322 Protein of unknown function DUF86; Region: DUF86; cl01031 681288002323 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 681288002324 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 681288002325 active site 681288002326 motif I; other site 681288002327 motif II; other site 681288002328 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 681288002329 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 681288002330 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288002331 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 681288002332 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 681288002333 AMP-binding enzyme; Region: AMP-binding; cl15778 681288002334 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 681288002335 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 681288002336 Phosphopantetheine attachment site; Region: PP-binding; cl09936 681288002337 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 681288002338 DltD N-terminal region; Region: DltD_N; pfam04915 681288002339 DltD central region; Region: DltD_M; pfam04918 681288002340 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 681288002341 NifU-like domain; Region: NifU; cl00484 681288002342 Protein of unknown function (DUF1462); Region: DUF1462; cl11552 681288002343 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 681288002344 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 681288002345 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 681288002346 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 681288002347 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 681288002348 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 681288002349 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 681288002350 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 681288002351 interface (dimer of trimers) [polypeptide binding]; other site 681288002352 Substrate-binding/catalytic site; other site 681288002353 Zn-binding sites [ion binding]; other site 681288002354 Predicted permease [General function prediction only]; Region: COG2056 681288002355 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 681288002356 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 681288002357 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 681288002358 CoenzymeA binding site [chemical binding]; other site 681288002359 subunit interaction site [polypeptide binding]; other site 681288002360 PHB binding site; other site 681288002361 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288002362 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 681288002363 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 681288002364 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 681288002365 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 681288002366 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 681288002367 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 681288002368 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 681288002369 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 681288002370 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 681288002371 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 681288002372 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 681288002373 Kinase associated protein B; Region: KapB; pfam08810 681288002374 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 681288002375 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 681288002376 active site 681288002377 general stress protein 13; Validated; Region: PRK08059 681288002378 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 681288002379 RNA binding site [nucleotide binding]; other site 681288002380 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 681288002381 putative active site [active] 681288002382 putative FMN binding site [chemical binding]; other site 681288002383 putative substrate binding site [chemical binding]; other site 681288002384 putative catalytic residue [active] 681288002385 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 681288002386 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 681288002387 inhibitor-cofactor binding pocket; inhibition site 681288002388 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288002389 catalytic residue [active] 681288002390 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 681288002391 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 681288002392 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 681288002393 NAD(P) binding site [chemical binding]; other site 681288002394 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 681288002395 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 681288002396 active site 681288002397 catalytic site [active] 681288002398 metal binding site [ion binding]; metal-binding site 681288002399 argininosuccinate lyase; Provisional; Region: PRK00855 681288002400 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 681288002401 active sites [active] 681288002402 tetramer interface [polypeptide binding]; other site 681288002403 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 681288002404 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 681288002405 ANP binding site [chemical binding]; other site 681288002406 Substrate Binding Site II [chemical binding]; other site 681288002407 Substrate Binding Site I [chemical binding]; other site 681288002408 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 681288002409 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 681288002410 active site 681288002411 dimer interface [polypeptide binding]; other site 681288002412 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 681288002413 dimer interface [polypeptide binding]; other site 681288002414 active site 681288002415 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 681288002416 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 681288002417 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 681288002418 Catalytic site [active] 681288002419 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 681288002420 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 681288002421 Catalytic site [active] 681288002422 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 681288002423 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 681288002424 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 681288002425 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288002426 Family description; Region: UvrD_C_2; cl15862 681288002427 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 681288002428 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 681288002429 Protein of unknown function (DUF1516); Region: DUF1516; cl11654 681288002430 coenzyme A disulfide reductase; Provisional; Region: PRK13512 681288002431 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 681288002432 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 681288002433 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 681288002434 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 681288002435 active site 681288002436 motif I; other site 681288002437 motif II; other site 681288002438 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 681288002439 Domain of unknown function DUF59; Region: DUF59; cl00941 681288002440 OpgC protein; Region: OpgC_C; cl00792 681288002441 Acyltransferase family; Region: Acyl_transf_3; pfam01757 681288002442 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 681288002443 catalytic triad [active] 681288002444 catalytic triad [active] 681288002445 oxyanion hole [active] 681288002446 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 681288002447 Clp amino terminal domain; Region: Clp_N; pfam02861 681288002448 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 681288002449 Walker A motif; other site 681288002450 ATP binding site [chemical binding]; other site 681288002451 Walker B motif; other site 681288002452 arginine finger; other site 681288002453 Plant ATP synthase F0; Region: YMF19; cl07975 681288002454 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 681288002455 Walker A motif; other site 681288002456 ATP binding site [chemical binding]; other site 681288002457 Walker B motif; other site 681288002458 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 681288002459 Transcriptional regulator [Transcription]; Region: LysR; COG0583 681288002460 Helix-turn-helix domains; Region: HTH; cl00088 681288002461 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 681288002462 dimerization interface [polypeptide binding]; other site 681288002463 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 681288002464 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 681288002465 substrate binding site [chemical binding]; other site 681288002466 MAP domain; Region: MAP; pfam03642 681288002467 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 681288002468 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 681288002469 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 681288002470 dimer interface [polypeptide binding]; other site 681288002471 active site 681288002472 CoA binding pocket [chemical binding]; other site 681288002473 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 681288002474 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 681288002475 dimer interface [polypeptide binding]; other site 681288002476 active site 681288002477 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 681288002478 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 681288002479 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288002480 dimer interface [polypeptide binding]; other site 681288002481 conserved gate region; other site 681288002482 putative PBP binding loops; other site 681288002483 ABC-ATPase subunit interface; other site 681288002484 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288002485 dimer interface [polypeptide binding]; other site 681288002486 conserved gate region; other site 681288002487 putative PBP binding loops; other site 681288002488 ABC-ATPase subunit interface; other site 681288002489 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 681288002490 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 681288002491 Walker A/P-loop; other site 681288002492 ATP binding site [chemical binding]; other site 681288002493 Q-loop/lid; other site 681288002494 ABC transporter signature motif; other site 681288002495 Walker B; other site 681288002496 D-loop; other site 681288002497 H-loop/switch region; other site 681288002498 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 681288002499 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 681288002500 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 681288002501 Walker A/P-loop; other site 681288002502 ATP binding site [chemical binding]; other site 681288002503 Q-loop/lid; other site 681288002504 ABC transporter signature motif; other site 681288002505 Walker B; other site 681288002506 D-loop; other site 681288002507 H-loop/switch region; other site 681288002508 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 681288002509 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 681288002510 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 681288002511 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 681288002512 peptide binding site [polypeptide binding]; other site 681288002513 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 681288002514 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 681288002515 peptide binding site [polypeptide binding]; other site 681288002516 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 681288002517 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 681288002518 Walker A/P-loop; other site 681288002519 ATP binding site [chemical binding]; other site 681288002520 Q-loop/lid; other site 681288002521 ABC transporter signature motif; other site 681288002522 Walker B; other site 681288002523 D-loop; other site 681288002524 H-loop/switch region; other site 681288002525 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 681288002526 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 681288002527 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 681288002528 Walker A/P-loop; other site 681288002529 ATP binding site [chemical binding]; other site 681288002530 Q-loop/lid; other site 681288002531 ABC transporter signature motif; other site 681288002532 Walker B; other site 681288002533 D-loop; other site 681288002534 H-loop/switch region; other site 681288002535 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 681288002536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288002537 dimer interface [polypeptide binding]; other site 681288002538 conserved gate region; other site 681288002539 putative PBP binding loops; other site 681288002540 ABC-ATPase subunit interface; other site 681288002541 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 681288002542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288002543 dimer interface [polypeptide binding]; other site 681288002544 conserved gate region; other site 681288002545 putative PBP binding loops; other site 681288002546 ABC-ATPase subunit interface; other site 681288002547 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 681288002548 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 681288002549 active site 681288002550 HIGH motif; other site 681288002551 dimer interface [polypeptide binding]; other site 681288002552 KMSKS motif; other site 681288002553 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 681288002554 ArsC family; Region: ArsC; pfam03960 681288002555 putative catalytic residues [active] 681288002556 thiol/disulfide switch; other site 681288002557 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 681288002558 Transposase; Region: DDE_Tnp_ISL3; pfam01610 681288002559 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 681288002560 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 681288002561 Competence protein CoiA-like family; Region: CoiA; cl11541 681288002562 oligoendopeptidase F; Region: pepF; TIGR00181 681288002563 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 681288002564 active site 681288002565 Zn binding site [ion binding]; other site 681288002566 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 681288002567 Thioredoxin; Region: Thioredoxin_5; pfam13743 681288002568 catalytic residues [active] 681288002569 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 681288002570 apolar tunnel; other site 681288002571 heme binding site [chemical binding]; other site 681288002572 dimerization interface [polypeptide binding]; other site 681288002573 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 681288002574 putative active site [active] 681288002575 putative metal binding residues [ion binding]; other site 681288002576 signature motif; other site 681288002577 putative triphosphate binding site [ion binding]; other site 681288002578 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 681288002579 synthetase active site [active] 681288002580 NTP binding site [chemical binding]; other site 681288002581 metal binding site [ion binding]; metal-binding site 681288002582 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 681288002583 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 681288002584 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 681288002585 active site 681288002586 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 681288002587 MgtE intracellular N domain; Region: MgtE_N; cl15244 681288002588 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 681288002589 Divalent cation transporter; Region: MgtE; cl00786 681288002590 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 681288002591 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 681288002592 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 681288002593 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288002594 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 681288002595 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 681288002596 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 681288002597 NAD binding site [chemical binding]; other site 681288002598 homotetramer interface [polypeptide binding]; other site 681288002599 homodimer interface [polypeptide binding]; other site 681288002600 substrate binding site [chemical binding]; other site 681288002601 active site 681288002602 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 681288002603 Domain of unknown function DUF20; Region: UPF0118; pfam01594 681288002604 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 681288002605 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 681288002606 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 681288002607 Putative esterase; Region: Esterase; pfam00756 681288002608 hypothetical protein; Provisional; Region: PRK13679 681288002609 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 681288002610 Major Facilitator Superfamily; Region: MFS_1; pfam07690 681288002611 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288002612 putative substrate translocation pore; other site 681288002613 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 681288002614 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 681288002615 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 681288002616 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 681288002617 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 681288002618 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 681288002619 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 681288002620 YueH-like protein; Region: YueH; pfam14166 681288002621 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 681288002622 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 681288002623 G1 box; other site 681288002624 putative GEF interaction site [polypeptide binding]; other site 681288002625 GTP/Mg2+ binding site [chemical binding]; other site 681288002626 Switch I region; other site 681288002627 G2 box; other site 681288002628 G3 box; other site 681288002629 Switch II region; other site 681288002630 G4 box; other site 681288002631 G5 box; other site 681288002632 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 681288002633 SAAV_0983 681288002634 Integral membrane protein TerC family; Region: TerC; cl10468 681288002635 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 681288002636 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 681288002637 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 681288002638 Cation transport protein; Region: TrkH; cl10514 681288002639 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 681288002640 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 681288002641 active site 681288002642 metal binding site [ion binding]; metal-binding site 681288002643 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 681288002644 ComK protein; Region: ComK; cl11560 681288002645 IDEAL domain; Region: IDEAL; cl07452 681288002646 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 681288002647 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 681288002648 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 681288002649 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 681288002650 CAAX protease self-immunity; Region: Abi; cl00558 681288002651 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 681288002652 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 681288002653 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 681288002654 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 681288002655 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 681288002656 Walker A/P-loop; other site 681288002657 ATP binding site [chemical binding]; other site 681288002658 Q-loop/lid; other site 681288002659 ABC transporter signature motif; other site 681288002660 Walker B; other site 681288002661 D-loop; other site 681288002662 H-loop/switch region; other site 681288002663 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 681288002664 DoxX; Region: DoxX; cl00976 681288002665 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 681288002666 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 681288002667 siderophore binding site; other site 681288002668 TM2 domain; Region: TM2; cl00984 681288002669 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 681288002670 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 681288002671 Coenzyme A binding pocket [chemical binding]; other site 681288002672 UbiA prenyltransferase family; Region: UbiA; cl00337 681288002673 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 681288002674 chorismate binding enzyme; Region: Chorismate_bind; cl10555 681288002675 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 681288002676 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 681288002677 dimer interface [polypeptide binding]; other site 681288002678 tetramer interface [polypeptide binding]; other site 681288002679 PYR/PP interface [polypeptide binding]; other site 681288002680 TPP binding site [chemical binding]; other site 681288002681 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 681288002682 TPP-binding site; other site 681288002683 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 681288002684 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 681288002685 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 681288002686 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 681288002687 substrate binding site [chemical binding]; other site 681288002688 oxyanion hole (OAH) forming residues; other site 681288002689 trimer interface [polypeptide binding]; other site 681288002690 Staphostatin B; Region: Staphostatin_B; pfam09023 681288002691 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 681288002692 aminotransferase A; Validated; Region: PRK07683 681288002693 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 681288002694 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288002695 homodimer interface [polypeptide binding]; other site 681288002696 catalytic residue [active] 681288002697 OpgC protein; Region: OpgC_C; cl00792 681288002698 Acyltransferase family; Region: Acyl_transf_3; pfam01757 681288002699 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 681288002700 Helix-turn-helix domains; Region: HTH; cl00088 681288002701 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 681288002702 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 681288002703 amidase catalytic site [active] 681288002704 Zn binding residues [ion binding]; other site 681288002705 substrate binding site [chemical binding]; other site 681288002706 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 681288002707 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 681288002708 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 681288002709 Coenzyme A binding pocket [chemical binding]; other site 681288002710 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 681288002711 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 681288002712 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 681288002713 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 681288002714 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 681288002715 Subunit I/III interface [polypeptide binding]; other site 681288002716 Subunit III/IV interface [polypeptide binding]; other site 681288002717 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 681288002718 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 681288002719 D-pathway; other site 681288002720 Putative ubiquinol binding site [chemical binding]; other site 681288002721 Low-spin heme (heme b) binding site [chemical binding]; other site 681288002722 Putative water exit pathway; other site 681288002723 Binuclear center (heme o3/CuB) [ion binding]; other site 681288002724 K-pathway; other site 681288002725 Putative proton exit pathway; other site 681288002726 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 681288002727 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 681288002728 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 681288002729 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 681288002730 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175 681288002731 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 681288002732 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 681288002733 homodimer interface [polypeptide binding]; other site 681288002734 NADP binding site [chemical binding]; other site 681288002735 substrate binding site [chemical binding]; other site 681288002736 AIR carboxylase; Region: AIRC; cl00310 681288002737 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288002738 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 681288002739 ATP-grasp domain; Region: ATP-grasp_4; cl03087 681288002740 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 681288002741 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 681288002742 ATP binding site [chemical binding]; other site 681288002743 active site 681288002744 substrate binding site [chemical binding]; other site 681288002745 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 681288002746 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 681288002747 putative active site [active] 681288002748 catalytic triad [active] 681288002749 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 681288002750 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 681288002751 dimerization interface [polypeptide binding]; other site 681288002752 ATP binding site [chemical binding]; other site 681288002753 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 681288002754 dimerization interface [polypeptide binding]; other site 681288002755 ATP binding site [chemical binding]; other site 681288002756 amidophosphoribosyltransferase; Provisional; Region: PRK07272 681288002757 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 681288002758 active site 681288002759 tetramer interface [polypeptide binding]; other site 681288002760 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 681288002761 active site 681288002762 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 681288002763 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 681288002764 dimerization interface [polypeptide binding]; other site 681288002765 putative ATP binding site [chemical binding]; other site 681288002766 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 681288002767 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 681288002768 active site 681288002769 substrate binding site [chemical binding]; other site 681288002770 cosubstrate binding site; other site 681288002771 catalytic site [active] 681288002772 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 681288002773 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 681288002774 purine monophosphate binding site [chemical binding]; other site 681288002775 dimer interface [polypeptide binding]; other site 681288002776 putative catalytic residues [active] 681288002777 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 681288002778 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 681288002779 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 681288002780 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790 681288002781 ATP-grasp domain; Region: ATP-grasp_4; cl03087 681288002782 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 681288002783 Cobalt transport protein; Region: CbiQ; cl00463 681288002784 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 681288002785 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 681288002786 Walker A/P-loop; other site 681288002787 ATP binding site [chemical binding]; other site 681288002788 Q-loop/lid; other site 681288002789 ABC transporter signature motif; other site 681288002790 Walker B; other site 681288002791 D-loop; other site 681288002792 H-loop/switch region; other site 681288002793 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 681288002794 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 681288002795 Walker A/P-loop; other site 681288002796 ATP binding site [chemical binding]; other site 681288002797 Q-loop/lid; other site 681288002798 ABC transporter signature motif; other site 681288002799 Walker B; other site 681288002800 D-loop; other site 681288002801 H-loop/switch region; other site 681288002802 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 681288002803 SAAV_1043 681288002804 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 681288002805 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 681288002806 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 681288002807 dimerization domain swap beta strand [polypeptide binding]; other site 681288002808 regulatory protein interface [polypeptide binding]; other site 681288002809 active site 681288002810 regulatory phosphorylation site [posttranslational modification]; other site 681288002811 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 681288002812 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 681288002813 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 681288002814 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 681288002815 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 681288002816 catalytic residues [active] 681288002817 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 681288002818 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 681288002819 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 681288002820 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288002821 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 681288002822 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 681288002823 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 681288002824 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 681288002825 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 681288002826 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 681288002827 active site 681288002828 catalytic residues [active] 681288002829 metal binding site [ion binding]; metal-binding site 681288002830 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 681288002831 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 681288002832 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 681288002833 TPP-binding site [chemical binding]; other site 681288002834 tetramer interface [polypeptide binding]; other site 681288002835 heterodimer interface [polypeptide binding]; other site 681288002836 phosphorylation loop region [posttranslational modification] 681288002837 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 681288002838 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 681288002839 alpha subunit interface [polypeptide binding]; other site 681288002840 TPP binding site [chemical binding]; other site 681288002841 heterodimer interface [polypeptide binding]; other site 681288002842 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 681288002843 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 681288002844 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 681288002845 E3 interaction surface; other site 681288002846 lipoyl attachment site [posttranslational modification]; other site 681288002847 e3 binding domain; Region: E3_binding; pfam02817 681288002848 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 681288002849 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 681288002850 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288002851 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 681288002852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 681288002853 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 681288002854 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 681288002855 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 681288002856 non-specific DNA binding site [nucleotide binding]; other site 681288002857 salt bridge; other site 681288002858 sequence-specific DNA binding site [nucleotide binding]; other site 681288002859 Cupin domain; Region: Cupin_2; cl09118 681288002860 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 681288002861 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288002862 Walker A/P-loop; other site 681288002863 ATP binding site [chemical binding]; other site 681288002864 Q-loop/lid; other site 681288002865 ABC transporter signature motif; other site 681288002866 Walker B; other site 681288002867 D-loop; other site 681288002868 H-loop/switch region; other site 681288002869 TOBE domain; Region: TOBE_2; cl01440 681288002870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288002871 putative PBP binding loops; other site 681288002872 dimer interface [polypeptide binding]; other site 681288002873 ABC-ATPase subunit interface; other site 681288002874 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 681288002875 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 681288002876 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 681288002877 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 681288002878 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 681288002879 Transposase; Region: DDE_Tnp_ISL3; pfam01610 681288002880 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 681288002881 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 681288002882 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 681288002883 Protein of unknown function (DUF1054); Region: DUF1054; cl11544 681288002884 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 681288002885 active site 681288002886 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 681288002887 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 681288002888 G1 box; other site 681288002889 putative GEF interaction site [polypeptide binding]; other site 681288002890 GTP/Mg2+ binding site [chemical binding]; other site 681288002891 Switch I region; other site 681288002892 G2 box; other site 681288002893 G3 box; other site 681288002894 Switch II region; other site 681288002895 G4 box; other site 681288002896 G5 box; other site 681288002897 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 681288002898 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 681288002899 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; cl11558 681288002900 Protein of unknown function (DUF1507); Region: DUF1507; cl11487 681288002901 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 681288002902 pyruvate carboxylase; Reviewed; Region: PRK12999 681288002903 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 681288002904 ATP-grasp domain; Region: ATP-grasp_4; cl03087 681288002905 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 681288002906 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 681288002907 active site 681288002908 catalytic residues [active] 681288002909 metal binding site [ion binding]; metal-binding site 681288002910 homodimer binding site [polypeptide binding]; other site 681288002911 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 681288002912 carboxyltransferase (CT) interaction site; other site 681288002913 biotinylation site [posttranslational modification]; other site 681288002914 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 681288002915 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 681288002916 UbiA prenyltransferase family; Region: UbiA; cl00337 681288002917 Protein of unknown function (DUF420); Region: DUF420; cl00989 681288002918 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 681288002919 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 681288002920 Protein of unknown function (DUF964); Region: DUF964; cl01483 681288002921 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 681288002922 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 681288002923 putative active site [active] 681288002924 catalytic site [active] 681288002925 putative metal binding site [ion binding]; other site 681288002926 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 681288002927 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 681288002928 S-adenosylmethionine binding site [chemical binding]; other site 681288002929 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 681288002930 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 681288002931 active site 681288002932 (T/H)XGH motif; other site 681288002933 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 681288002934 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 681288002935 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 681288002936 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 681288002937 heme uptake protein IsdB; Region: IsdB; TIGR03657 681288002938 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 681288002939 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cl02760 681288002940 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 681288002941 heme-binding site [chemical binding]; other site 681288002942 Gram positive anchor; Region: Gram_pos_anchor; cl15427 681288002943 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 681288002944 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 681288002945 heme-binding site [chemical binding]; other site 681288002946 heme uptake protein IsdC; Region: IsdC; TIGR03656 681288002947 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 681288002948 heme-binding site [chemical binding]; other site 681288002949 sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068 681288002950 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 681288002951 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 681288002952 intersubunit interface [polypeptide binding]; other site 681288002953 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 681288002954 ABC-ATPase subunit interface; other site 681288002955 dimer interface [polypeptide binding]; other site 681288002956 putative PBP binding regions; other site 681288002957 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 681288002958 active site 681288002959 catalytic site [active] 681288002960 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 681288002961 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 681288002962 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 681288002963 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 681288002964 SAAV_1104 681288002965 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 681288002966 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 681288002967 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 681288002968 dimer interface [polypeptide binding]; other site 681288002969 motif 1; other site 681288002970 active site 681288002971 motif 2; other site 681288002972 motif 3; other site 681288002973 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 681288002974 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 681288002975 putative tRNA-binding site [nucleotide binding]; other site 681288002976 B3/4 domain; Region: B3_4; cl11458 681288002977 tRNA synthetase B5 domain; Region: B5; cl08394 681288002978 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 681288002979 dimer interface [polypeptide binding]; other site 681288002980 motif 1; other site 681288002981 motif 3; other site 681288002982 motif 2; other site 681288002983 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 681288002984 ribonuclease HIII; Provisional; Region: PRK00996 681288002985 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 681288002986 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 681288002987 RNA/DNA hybrid binding site [nucleotide binding]; other site 681288002988 active site 681288002989 Cell division protein ZapA; Region: ZapA; cl01146 681288002990 Colicin V production protein; Region: Colicin_V; cl00567 681288002991 hypothetical protein; Provisional; Region: PRK08609 681288002992 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 681288002993 active site 681288002994 primer binding site [nucleotide binding]; other site 681288002995 NTP binding site [chemical binding]; other site 681288002996 metal binding triad [ion binding]; metal-binding site 681288002997 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 681288002998 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 681288002999 Walker A/P-loop; other site 681288003000 ATP binding site [chemical binding]; other site 681288003001 Q-loop/lid; other site 681288003002 ABC transporter signature motif; other site 681288003003 Walker B; other site 681288003004 D-loop; other site 681288003005 H-loop/switch region; other site 681288003006 Smr domain; Region: Smr; cl02619 681288003007 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 681288003008 catalytic residues [active] 681288003009 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 681288003010 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 681288003011 GIY-YIG motif/motif A; other site 681288003012 active site 681288003013 catalytic site [active] 681288003014 putative DNA binding site [nucleotide binding]; other site 681288003015 metal binding site [ion binding]; metal-binding site 681288003016 UvrB/uvrC motif; Region: UVR; pfam02151 681288003017 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 681288003018 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 681288003019 putative Iron-sulfur protein interface [polypeptide binding]; other site 681288003020 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 681288003021 proximal heme binding site [chemical binding]; other site 681288003022 distal heme binding site [chemical binding]; other site 681288003023 putative dimer interface [polypeptide binding]; other site 681288003024 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 681288003025 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288003026 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 681288003027 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 681288003028 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 681288003029 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 681288003030 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 681288003031 active site 681288003032 dimerization interface [polypeptide binding]; other site 681288003033 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 681288003034 active site 681288003035 metal binding site [ion binding]; metal-binding site 681288003036 homotetramer interface [polypeptide binding]; other site 681288003037 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 681288003038 formyl peptide receptor-like 1 inhibitory protein; Reviewed; Region: PRK13033 681288003039 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 681288003040 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 681288003041 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 681288003042 Transposase; Region: DDE_Tnp_ISL3; pfam01610 681288003043 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 681288003044 superantigen-like protein; Reviewed; Region: PRK13350 681288003045 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288003046 superantigen-like protein; Reviewed; Region: PRK13349 681288003047 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288003048 superantigen-like protein; Reviewed; Region: PRK13043 681288003049 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288003050 ornithine carbamoyltransferase; Provisional; Region: PRK04284 681288003051 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 681288003052 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288003053 carbamate kinase; Reviewed; Region: PRK12686 681288003054 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 681288003055 putative substrate binding site [chemical binding]; other site 681288003056 nucleotide binding site [chemical binding]; other site 681288003057 nucleotide binding site [chemical binding]; other site 681288003058 homodimer interface [polypeptide binding]; other site 681288003059 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 681288003060 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 681288003061 gating phenylalanine in ion channel; other site 681288003062 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 681288003063 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 681288003064 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 681288003065 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 681288003066 motif II; other site 681288003067 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 681288003068 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 681288003069 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 681288003070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 681288003071 MraZ protein; Region: MraZ; pfam02381 681288003072 MraZ protein; Region: MraZ; pfam02381 681288003073 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 681288003074 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288003075 Septum formation initiator; Region: DivIC; cl11433 681288003076 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 681288003077 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 681288003078 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 681288003079 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 681288003080 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 681288003081 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 681288003082 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 681288003083 Mg++ binding site [ion binding]; other site 681288003084 putative catalytic motif [active] 681288003085 putative substrate binding site [chemical binding]; other site 681288003086 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 681288003087 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288003088 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 681288003089 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 681288003090 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 681288003091 Cell division protein FtsQ; Region: FtsQ; pfam03799 681288003092 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 681288003093 Cell division protein FtsA; Region: FtsA; cl11496 681288003094 Cell division protein FtsA; Region: FtsA; cl11496 681288003095 cell division protein FtsZ; Validated; Region: PRK09330 681288003096 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 681288003097 nucleotide binding site [chemical binding]; other site 681288003098 SulA interaction site; other site 681288003099 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 681288003100 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 681288003101 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 681288003102 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 681288003103 catalytic residue [active] 681288003104 Protein of unknown function (DUF552); Region: DUF552; cl00775 681288003105 YGGT family; Region: YGGT; cl00508 681288003106 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 681288003107 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 681288003108 RNA binding surface [nucleotide binding]; other site 681288003109 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 681288003110 DivIVA domain; Region: DivI1A_domain; TIGR03544 681288003111 SAAV_1164 681288003112 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 681288003113 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 681288003114 HIGH motif; other site 681288003115 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 681288003116 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 681288003117 active site 681288003118 KMSKS motif; other site 681288003119 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 681288003120 tRNA binding surface [nucleotide binding]; other site 681288003121 anticodon binding site; other site 681288003122 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 681288003123 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 681288003124 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 681288003125 active site 681288003126 metal binding site [ion binding]; metal-binding site 681288003127 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 681288003128 lipoprotein signal peptidase; Provisional; Region: PRK14787 681288003129 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 681288003130 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 681288003131 RNA binding surface [nucleotide binding]; other site 681288003132 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 681288003133 active site 681288003134 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 681288003135 uracil transporter; Provisional; Region: PRK10720 681288003136 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 681288003137 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 681288003138 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 681288003139 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288003140 dihydroorotase; Validated; Region: pyrC; PRK09357 681288003141 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 681288003142 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 681288003143 active site 681288003144 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 681288003145 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 681288003146 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 681288003147 catalytic site [active] 681288003148 subunit interface [polypeptide binding]; other site 681288003149 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 681288003150 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 681288003151 ATP-grasp domain; Region: ATP-grasp_4; cl03087 681288003152 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 681288003153 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 681288003154 ATP-grasp domain; Region: ATP-grasp_4; cl03087 681288003155 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 681288003156 IMP binding site; other site 681288003157 dimer interface [polypeptide binding]; other site 681288003158 interdomain contacts; other site 681288003159 partial ornithine binding site; other site 681288003160 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 681288003161 active site 681288003162 dimer interface [polypeptide binding]; other site 681288003163 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 681288003164 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 681288003165 active site 681288003166 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 681288003167 dimer interface [polypeptide binding]; other site 681288003168 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 681288003169 Domain of unknown function (DUF814); Region: DUF814; pfam05670 681288003170 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 681288003171 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 681288003172 catalytic site [active] 681288003173 G-X2-G-X-G-K; other site 681288003174 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 681288003175 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 681288003176 Flavoprotein; Region: Flavoprotein; cl08021 681288003177 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 681288003178 primosome assembly protein PriA; Validated; Region: PRK05580 681288003179 primosome assembly protein PriA; Validated; Region: PRK05580 681288003180 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 681288003181 ATP binding site [chemical binding]; other site 681288003182 putative Mg++ binding site [ion binding]; other site 681288003183 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288003184 TM2 domain; Region: TM2; cl00984 681288003185 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 681288003186 active site 681288003187 catalytic residues [active] 681288003188 metal binding site [ion binding]; metal-binding site 681288003189 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 681288003190 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 681288003191 putative active site [active] 681288003192 substrate binding site [chemical binding]; other site 681288003193 putative cosubstrate binding site; other site 681288003194 catalytic site [active] 681288003195 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 681288003196 substrate binding site [chemical binding]; other site 681288003197 16S rRNA methyltransferase B; Provisional; Region: PRK14902 681288003198 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 681288003199 putative RNA binding site [nucleotide binding]; other site 681288003200 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 681288003201 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 681288003202 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 681288003203 FeS/SAM binding site; other site 681288003204 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 681288003205 Protein phosphatase 2C; Region: PP2C; pfam00481 681288003206 active site 681288003207 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 681288003208 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 681288003209 active site 681288003210 ATP binding site [chemical binding]; other site 681288003211 substrate binding site [chemical binding]; other site 681288003212 activation loop (A-loop); other site 681288003213 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 681288003214 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 681288003215 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 681288003216 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 681288003217 GTPase RsgA; Reviewed; Region: PRK00098 681288003218 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 681288003219 RNA binding site [nucleotide binding]; other site 681288003220 homodimer interface [polypeptide binding]; other site 681288003221 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 681288003222 GTPase/Zn-binding domain interface [polypeptide binding]; other site 681288003223 GTP/Mg2+ binding site [chemical binding]; other site 681288003224 G4 box; other site 681288003225 G5 box; other site 681288003226 G1 box; other site 681288003227 Switch I region; other site 681288003228 G2 box; other site 681288003229 G3 box; other site 681288003230 Switch II region; other site 681288003231 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 681288003232 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 681288003233 substrate binding site [chemical binding]; other site 681288003234 hexamer interface [polypeptide binding]; other site 681288003235 metal binding site [ion binding]; metal-binding site 681288003236 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 681288003237 Thiamine pyrophosphokinase; Region: TPK; cd07995 681288003238 active site 681288003239 dimerization interface [polypeptide binding]; other site 681288003240 thiamine binding site [chemical binding]; other site 681288003241 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 681288003242 Asp23 family; Region: Asp23; cl00574 681288003243 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 681288003244 DAK2 domain; Region: Dak2; cl03685 681288003245 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 681288003246 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 681288003247 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 681288003248 generic binding surface II; other site 681288003249 ssDNA binding site; other site 681288003250 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 681288003251 ATP binding site [chemical binding]; other site 681288003252 putative Mg++ binding site [ion binding]; other site 681288003253 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 681288003254 nucleotide binding region [chemical binding]; other site 681288003255 ATP-binding site [chemical binding]; other site 681288003256 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 681288003257 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 681288003258 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 681288003259 Acyl transferase domain; Region: Acyl_transf_1; cl08282 681288003260 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 681288003261 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 681288003262 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 681288003263 NAD(P) binding site [chemical binding]; other site 681288003264 homotetramer interface [polypeptide binding]; other site 681288003265 homodimer interface [polypeptide binding]; other site 681288003266 active site 681288003267 Phosphopantetheine attachment site; Region: PP-binding; cl09936 681288003268 ribonuclease III; Reviewed; Region: rnc; PRK00102 681288003269 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 681288003270 dimerization interface [polypeptide binding]; other site 681288003271 active site 681288003272 metal binding site [ion binding]; metal-binding site 681288003273 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 681288003274 dsRNA binding site [nucleotide binding]; other site 681288003275 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 681288003276 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 681288003277 Walker A/P-loop; other site 681288003278 ATP binding site [chemical binding]; other site 681288003279 Q-loop/lid; other site 681288003280 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cl00148 681288003281 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 681288003282 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 681288003283 ABC transporter signature motif; other site 681288003284 Walker B; other site 681288003285 D-loop; other site 681288003286 H-loop/switch region; other site 681288003287 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 681288003288 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 681288003289 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 681288003290 P loop; other site 681288003291 GTP binding site [chemical binding]; other site 681288003292 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 681288003293 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 681288003294 signal recognition particle protein; Provisional; Region: PRK10867 681288003295 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 681288003296 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 681288003297 P loop; other site 681288003298 GTP binding site [chemical binding]; other site 681288003299 Signal peptide binding domain; Region: SRP_SPB; pfam02978 681288003300 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 681288003301 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 681288003302 RimM N-terminal domain; Region: RimM; pfam01782 681288003303 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 681288003304 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 681288003305 SAAV_1214 681288003306 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 681288003307 Predicted membrane protein [Function unknown]; Region: COG4485 681288003308 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 681288003309 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 681288003310 GTP/Mg2+ binding site [chemical binding]; other site 681288003311 G4 box; other site 681288003312 G5 box; other site 681288003313 G1 box; other site 681288003314 Switch I region; other site 681288003315 G2 box; other site 681288003316 G3 box; other site 681288003317 Switch II region; other site 681288003318 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 681288003319 RNA/DNA hybrid binding site [nucleotide binding]; other site 681288003320 active site 681288003321 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 681288003322 ATP-grasp domain; Region: ATP-grasp_4; cl03087 681288003323 CoA-ligase; Region: Ligase_CoA; cl02894 681288003324 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 681288003325 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288003326 CoA-ligase; Region: Ligase_CoA; cl02894 681288003327 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 681288003328 autolysin; Reviewed; Region: PRK06347 681288003329 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 681288003330 putative peptidoglycan binding site; other site 681288003331 NlpC/P60 family; Region: NLPC_P60; cl11438 681288003332 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 681288003333 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 681288003334 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 681288003335 DNA topoisomerase I; Validated; Region: PRK05582 681288003336 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 681288003337 active site 681288003338 interdomain interaction site; other site 681288003339 putative metal-binding site [ion binding]; other site 681288003340 nucleotide binding site [chemical binding]; other site 681288003341 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 681288003342 domain I; other site 681288003343 DNA binding groove [nucleotide binding] 681288003344 phosphate binding site [ion binding]; other site 681288003345 domain II; other site 681288003346 domain III; other site 681288003347 nucleotide binding site [chemical binding]; other site 681288003348 catalytic site [active] 681288003349 domain IV; other site 681288003350 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 681288003351 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 681288003352 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 681288003353 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288003354 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 681288003355 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 681288003356 active site 681288003357 DNA binding site [nucleotide binding] 681288003358 Int/Topo IB signature motif; other site 681288003359 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 681288003360 active site 681288003361 HslU subunit interaction site [polypeptide binding]; other site 681288003362 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 681288003363 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 681288003364 Walker A motif; other site 681288003365 ATP binding site [chemical binding]; other site 681288003366 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288003367 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 681288003368 transcriptional repressor CodY; Validated; Region: PRK04158 681288003369 CodY GAF-like domain; Region: CodY; pfam06018 681288003370 Helix-turn-helix domains; Region: HTH; cl00088 681288003371 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 681288003372 rRNA interaction site [nucleotide binding]; other site 681288003373 S8 interaction site; other site 681288003374 putative laminin-1 binding site; other site 681288003375 elongation factor Ts; Provisional; Region: tsf; PRK09377 681288003376 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 681288003377 Elongation factor TS; Region: EF_TS; pfam00889 681288003378 Elongation factor TS; Region: EF_TS; pfam00889 681288003379 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 681288003380 putative nucleotide binding site [chemical binding]; other site 681288003381 uridine monophosphate binding site [chemical binding]; other site 681288003382 homohexameric interface [polypeptide binding]; other site 681288003383 ribosome recycling factor; Reviewed; Region: frr; PRK00083 681288003384 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 681288003385 hinge region; other site 681288003386 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 681288003387 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 681288003388 catalytic residue [active] 681288003389 putative FPP diphosphate binding site; other site 681288003390 putative FPP binding hydrophobic cleft; other site 681288003391 dimer interface [polypeptide binding]; other site 681288003392 putative IPP diphosphate binding site; other site 681288003393 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 681288003394 RIP metalloprotease RseP; Region: TIGR00054 681288003395 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 681288003396 active site 681288003397 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 681288003398 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 681288003399 protein binding site [polypeptide binding]; other site 681288003400 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 681288003401 putative substrate binding region [chemical binding]; other site 681288003402 prolyl-tRNA synthetase; Provisional; Region: PRK09194 681288003403 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 681288003404 dimer interface [polypeptide binding]; other site 681288003405 motif 1; other site 681288003406 active site 681288003407 motif 2; other site 681288003408 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 681288003409 putative deacylase active site [active] 681288003410 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 681288003411 active site 681288003412 motif 3; other site 681288003413 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 681288003414 anticodon binding site; other site 681288003415 DNA polymerase III PolC; Validated; Region: polC; PRK00448 681288003416 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 681288003417 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 681288003418 generic binding surface II; other site 681288003419 generic binding surface I; other site 681288003420 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 681288003421 active site 681288003422 catalytic site [active] 681288003423 substrate binding site [chemical binding]; other site 681288003424 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 681288003425 ribosome maturation protein RimP; Reviewed; Region: PRK00092 681288003426 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 681288003427 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 681288003428 Sm1 motif; other site 681288003429 predicted subunit interaction site [polypeptide binding]; other site 681288003430 RNA binding pocket [nucleotide binding]; other site 681288003431 Sm2 motif; other site 681288003432 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 681288003433 NusA N-terminal domain; Region: NusA_N; pfam08529 681288003434 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 681288003435 RNA binding site [nucleotide binding]; other site 681288003436 homodimer interface [polypeptide binding]; other site 681288003437 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 681288003438 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 681288003439 G-X-X-G motif; other site 681288003440 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 681288003441 putative RNA binding cleft [nucleotide binding]; other site 681288003442 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 681288003443 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 681288003444 translation initiation factor IF-2; Region: IF-2; TIGR00487 681288003445 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 681288003446 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 681288003447 G1 box; other site 681288003448 putative GEF interaction site [polypeptide binding]; other site 681288003449 GTP/Mg2+ binding site [chemical binding]; other site 681288003450 Switch I region; other site 681288003451 G2 box; other site 681288003452 G3 box; other site 681288003453 Switch II region; other site 681288003454 G4 box; other site 681288003455 G5 box; other site 681288003456 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 681288003457 Translation-initiation factor 2; Region: IF-2; pfam11987 681288003458 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 681288003459 Ribosome-binding factor A; Region: RBFA; cl00542 681288003460 tRNA pseudouridine synthase B; Provisional; Region: PRK14123 681288003461 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 681288003462 RNA binding site [nucleotide binding]; other site 681288003463 active site 681288003464 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 681288003465 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 681288003466 active site 681288003467 Riboflavin kinase; Region: Flavokinase; cl03312 681288003468 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 681288003469 16S/18S rRNA binding site [nucleotide binding]; other site 681288003470 S13e-L30e interaction site [polypeptide binding]; other site 681288003471 25S rRNA binding site [nucleotide binding]; other site 681288003472 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 681288003473 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 681288003474 RNase E interface [polypeptide binding]; other site 681288003475 trimer interface [polypeptide binding]; other site 681288003476 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 681288003477 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 681288003478 RNase E interface [polypeptide binding]; other site 681288003479 trimer interface [polypeptide binding]; other site 681288003480 active site 681288003481 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 681288003482 putative nucleic acid binding region [nucleotide binding]; other site 681288003483 G-X-X-G motif; other site 681288003484 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 681288003485 RNA binding site [nucleotide binding]; other site 681288003486 domain interface; other site 681288003487 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 681288003488 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 681288003489 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 681288003490 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 681288003491 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 681288003492 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288003493 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 681288003494 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 681288003495 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 681288003496 Helix-turn-helix domains; Region: HTH; cl00088 681288003497 UTRA domain; Region: UTRA; cl01230 681288003498 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 681288003499 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 681288003500 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 681288003501 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 681288003502 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 681288003503 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 681288003504 classical (c) SDRs; Region: SDR_c; cd05233 681288003505 NAD(P) binding site [chemical binding]; other site 681288003506 active site 681288003507 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 681288003508 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 681288003509 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 681288003510 non-specific DNA binding site [nucleotide binding]; other site 681288003511 salt bridge; other site 681288003512 sequence-specific DNA binding site [nucleotide binding]; other site 681288003513 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 681288003514 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 681288003515 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 681288003516 putative MPT binding site; other site 681288003517 recombinase A; Provisional; Region: recA; PRK09354 681288003518 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 681288003519 hexamer interface [polypeptide binding]; other site 681288003520 Walker A motif; other site 681288003521 ATP binding site [chemical binding]; other site 681288003522 Walker B motif; other site 681288003523 phosphodiesterase; Provisional; Region: PRK12704 681288003524 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 681288003525 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 681288003526 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 681288003527 putative active site [active] 681288003528 metal binding site [ion binding]; metal-binding site 681288003529 homodimer binding site [polypeptide binding]; other site 681288003530 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 681288003531 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 681288003532 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 681288003533 dimer interface [polypeptide binding]; other site 681288003534 PYR/PP interface [polypeptide binding]; other site 681288003535 TPP binding site [chemical binding]; other site 681288003536 substrate binding site [chemical binding]; other site 681288003537 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 681288003538 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 681288003539 TPP-binding site [chemical binding]; other site 681288003540 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 681288003541 Domain of unknown function DUF77; Region: DUF77; cl00307 681288003542 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 681288003543 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 681288003544 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 681288003545 FeS/SAM binding site; other site 681288003546 TRAM domain; Region: TRAM; cl01282 681288003547 Protein of unknown function (DUF964); Region: DUF964; cl01483 681288003548 Thiamine-precursor transporter protein (ThiW); Region: ThiW; cl01952 681288003549 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 681288003550 MutS domain I; Region: MutS_I; pfam01624 681288003551 MutS domain II; Region: MutS_II; pfam05188 681288003552 MutS family domain IV; Region: MutS_IV; pfam05190 681288003553 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 681288003554 Walker A/P-loop; other site 681288003555 ATP binding site [chemical binding]; other site 681288003556 Q-loop/lid; other site 681288003557 ABC transporter signature motif; other site 681288003558 Walker B; other site 681288003559 D-loop; other site 681288003560 H-loop/switch region; other site 681288003561 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 681288003562 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 681288003563 ATP binding site [chemical binding]; other site 681288003564 Mg2+ binding site [ion binding]; other site 681288003565 G-X-G motif; other site 681288003566 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 681288003567 ATP binding site [chemical binding]; other site 681288003568 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 681288003569 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 681288003570 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 681288003571 amphipathic channel; other site 681288003572 Asn-Pro-Ala signature motifs; other site 681288003573 glycerol kinase; Provisional; Region: glpK; PRK00047 681288003574 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 681288003575 N- and C-terminal domain interface [polypeptide binding]; other site 681288003576 active site 681288003577 MgATP binding site [chemical binding]; other site 681288003578 catalytic site [active] 681288003579 metal binding site [ion binding]; metal-binding site 681288003580 glycerol binding site [chemical binding]; other site 681288003581 homotetramer interface [polypeptide binding]; other site 681288003582 homodimer interface [polypeptide binding]; other site 681288003583 FBP binding site [chemical binding]; other site 681288003584 protein IIAGlc interface [polypeptide binding]; other site 681288003585 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 681288003586 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 681288003587 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 681288003588 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288003589 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 681288003590 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 681288003591 Sm1 motif; other site 681288003592 intra - hexamer interaction site; other site 681288003593 inter - hexamer interaction site [polypeptide binding]; other site 681288003594 nucleotide binding pocket [chemical binding]; other site 681288003595 Sm2 motif; other site 681288003596 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 681288003597 catalytic residues [active] 681288003598 dimer interface [polypeptide binding]; other site 681288003599 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 681288003600 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 681288003601 HflX GTPase family; Region: HflX; cd01878 681288003602 G1 box; other site 681288003603 GTP/Mg2+ binding site [chemical binding]; other site 681288003604 Switch I region; other site 681288003605 G2 box; other site 681288003606 G3 box; other site 681288003607 Switch II region; other site 681288003608 G4 box; other site 681288003609 G5 box; other site 681288003610 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 681288003611 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 681288003612 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 681288003613 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 681288003614 DNA binding residues [nucleotide binding] 681288003615 putative dimer interface [polypeptide binding]; other site 681288003616 glutamine synthetase, type I; Region: GlnA; TIGR00653 681288003617 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 681288003618 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 681288003619 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 681288003620 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 681288003621 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 681288003622 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 681288003623 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 681288003624 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 681288003625 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 681288003626 catalytic residue [active] 681288003627 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 681288003628 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 681288003629 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 681288003630 putative active site [active] 681288003631 catalytic site [active] 681288003632 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 681288003633 putative active site [active] 681288003634 catalytic site [active] 681288003635 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 681288003636 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 681288003637 Walker A/P-loop; other site 681288003638 ATP binding site [chemical binding]; other site 681288003639 Q-loop/lid; other site 681288003640 ABC transporter signature motif; other site 681288003641 Walker B; other site 681288003642 D-loop; other site 681288003643 H-loop/switch region; other site 681288003644 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 681288003645 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 681288003646 Histidine kinase; Region: HisKA_3; pfam07730 681288003647 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 681288003648 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 681288003649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 681288003650 active site 681288003651 phosphorylation site [posttranslational modification] 681288003652 intermolecular recognition site; other site 681288003653 dimerization interface [polypeptide binding]; other site 681288003654 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 681288003655 DNA binding residues [nucleotide binding] 681288003656 dimerization interface [polypeptide binding]; other site 681288003657 Staphylococcal nuclease homologues; Region: SNc; smart00318 681288003658 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 681288003659 Catalytic site; other site 681288003660 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288003661 aspartate kinase; Reviewed; Region: PRK09034 681288003662 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 681288003663 putative catalytic residues [active] 681288003664 putative nucleotide binding site [chemical binding]; other site 681288003665 putative aspartate binding site [chemical binding]; other site 681288003666 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 681288003667 allosteric regulatory residue; other site 681288003668 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 681288003669 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 681288003670 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288003671 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 681288003672 threonine synthase; Reviewed; Region: PRK06721 681288003673 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 681288003674 homodimer interface [polypeptide binding]; other site 681288003675 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288003676 catalytic residue [active] 681288003677 homoserine kinase; Provisional; Region: PRK01212 681288003678 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 681288003679 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 681288003680 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 681288003681 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 681288003682 active site 681288003683 motif I; other site 681288003684 motif II; other site 681288003685 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 681288003686 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 681288003687 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 681288003688 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 681288003689 tetramer interface [polypeptide binding]; other site 681288003690 heme binding pocket [chemical binding]; other site 681288003691 NADPH binding site [chemical binding]; other site 681288003692 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 681288003693 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 681288003694 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 681288003695 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 681288003696 active site 681288003697 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 681288003698 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 681288003699 LexA repressor; Validated; Region: PRK00215 681288003700 Helix-turn-helix domains; Region: HTH; cl00088 681288003701 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 681288003702 Catalytic site [active] 681288003703 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 681288003704 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 681288003705 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 681288003706 TPP-binding site [chemical binding]; other site 681288003707 dimer interface [polypeptide binding]; other site 681288003708 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 681288003709 PYR/PP interface [polypeptide binding]; other site 681288003710 dimer interface [polypeptide binding]; other site 681288003711 TPP binding site [chemical binding]; other site 681288003712 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 681288003713 Uncharacterized protein family (UPF0154); Region: UPF0154; cl01536 681288003714 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 681288003715 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 681288003716 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 681288003717 active site 681288003718 metal binding site [ion binding]; metal-binding site 681288003719 DNA binding site [nucleotide binding] 681288003720 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 681288003721 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 681288003722 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 681288003723 Walker A/P-loop; other site 681288003724 ATP binding site [chemical binding]; other site 681288003725 Q-loop/lid; other site 681288003726 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 681288003727 ABC transporter signature motif; other site 681288003728 Walker B; other site 681288003729 D-loop; other site 681288003730 H-loop/switch region; other site 681288003731 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 681288003732 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 681288003733 BCCT family transporter; Region: BCCT; cl00569 681288003734 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 681288003735 aconitate hydratase; Validated; Region: PRK09277 681288003736 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 681288003737 substrate binding site [chemical binding]; other site 681288003738 ligand binding site [chemical binding]; other site 681288003739 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 681288003740 substrate binding site [chemical binding]; other site 681288003741 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 681288003742 active site 681288003743 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 681288003744 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 681288003745 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 681288003746 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 681288003747 ATP binding site [chemical binding]; other site 681288003748 Mg2+ binding site [ion binding]; other site 681288003749 G-X-G motif; other site 681288003750 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 681288003751 anchoring element; other site 681288003752 dimer interface [polypeptide binding]; other site 681288003753 ATP binding site [chemical binding]; other site 681288003754 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 681288003755 active site 681288003756 putative metal-binding site [ion binding]; other site 681288003757 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 681288003758 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 681288003759 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 681288003760 CAP-like domain; other site 681288003761 active site 681288003762 primary dimer interface [polypeptide binding]; other site 681288003763 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 681288003764 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 681288003765 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 681288003766 CAT RNA binding domain; Region: CAT_RBD; cl03904 681288003767 PRD domain; Region: PRD; cl15445 681288003768 PRD domain; Region: PRD; cl15445 681288003769 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 681288003770 Domain of unknown function DUF20; Region: UPF0118; pfam01594 681288003771 Predicted integral membrane protein [Function unknown]; Region: COG0392 681288003772 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 681288003773 Uncharacterized conserved protein [Function unknown]; Region: COG2898 681288003774 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 681288003775 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 681288003776 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 681288003777 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 681288003778 active site 1 [active] 681288003779 dimer interface [polypeptide binding]; other site 681288003780 hexamer interface [polypeptide binding]; other site 681288003781 active site 2 [active] 681288003782 DNA polymerase IV; Reviewed; Region: PRK03103 681288003783 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 681288003784 active site 681288003785 DNA binding site [nucleotide binding] 681288003786 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 681288003787 prephenate dehydrogenase; Validated; Region: PRK06545 681288003788 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288003789 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 681288003790 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 681288003791 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 681288003792 putative oligomer interface [polypeptide binding]; other site 681288003793 putative active site [active] 681288003794 metal binding site [ion binding]; metal-binding site 681288003795 SAAV_1347 681288003796 SAAV_1348 681288003797 anthranilate synthase component I; Provisional; Region: PRK13567 681288003798 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 681288003799 chorismate binding enzyme; Region: Chorismate_bind; cl10555 681288003800 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 681288003801 Glutamine amidotransferase class-I; Region: GATase; pfam00117 681288003802 glutamine binding [chemical binding]; other site 681288003803 catalytic triad [active] 681288003804 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 681288003805 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 681288003806 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 681288003807 active site 681288003808 ribulose/triose binding site [chemical binding]; other site 681288003809 phosphate binding site [ion binding]; other site 681288003810 substrate (anthranilate) binding pocket [chemical binding]; other site 681288003811 product (indole) binding pocket [chemical binding]; other site 681288003812 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 681288003813 active site 681288003814 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 681288003815 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 681288003816 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288003817 catalytic residue [active] 681288003818 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 681288003819 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 681288003820 substrate binding site [chemical binding]; other site 681288003821 active site 681288003822 catalytic residues [active] 681288003823 heterodimer interface [polypeptide binding]; other site 681288003824 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 681288003825 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 681288003826 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 681288003827 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 681288003828 active site 681288003829 motif I; other site 681288003830 motif II; other site 681288003831 SWIM zinc finger; Region: SWIM; cl15408 681288003832 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 681288003833 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 681288003834 Walker A/P-loop; other site 681288003835 ATP binding site [chemical binding]; other site 681288003836 Q-loop/lid; other site 681288003837 ABC transporter signature motif; other site 681288003838 Walker B; other site 681288003839 D-loop; other site 681288003840 H-loop/switch region; other site 681288003841 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 681288003842 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 681288003843 Walker A/P-loop; other site 681288003844 ATP binding site [chemical binding]; other site 681288003845 Q-loop/lid; other site 681288003846 ABC transporter signature motif; other site 681288003847 Walker B; other site 681288003848 D-loop; other site 681288003849 H-loop/switch region; other site 681288003850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288003851 dimer interface [polypeptide binding]; other site 681288003852 conserved gate region; other site 681288003853 putative PBP binding loops; other site 681288003854 ABC-ATPase subunit interface; other site 681288003855 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 681288003856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288003857 dimer interface [polypeptide binding]; other site 681288003858 conserved gate region; other site 681288003859 putative PBP binding loops; other site 681288003860 ABC-ATPase subunit interface; other site 681288003861 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 681288003862 oligoendopeptidase F; Region: pepF; TIGR00181 681288003863 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 681288003864 active site 681288003865 Zn binding site [ion binding]; other site 681288003866 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 681288003867 PhoU domain; Region: PhoU; pfam01895 681288003868 PhoU domain; Region: PhoU; pfam01895 681288003869 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 681288003870 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 681288003871 Walker A/P-loop; other site 681288003872 ATP binding site [chemical binding]; other site 681288003873 Q-loop/lid; other site 681288003874 ABC transporter signature motif; other site 681288003875 Walker B; other site 681288003876 D-loop; other site 681288003877 H-loop/switch region; other site 681288003878 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 681288003879 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288003880 dimer interface [polypeptide binding]; other site 681288003881 conserved gate region; other site 681288003882 putative PBP binding loops; other site 681288003883 ABC-ATPase subunit interface; other site 681288003884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288003885 dimer interface [polypeptide binding]; other site 681288003886 conserved gate region; other site 681288003887 ABC-ATPase subunit interface; other site 681288003888 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 681288003889 Transposase domain (DUF772); Region: DUF772; cl15789 681288003890 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 681288003891 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 681288003892 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 681288003893 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 681288003894 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 681288003895 ABC transporter; Region: ABC_tran_2; pfam12848 681288003896 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 681288003897 SAAV_1375 681288003898 aspartate kinase; Reviewed; Region: PRK06635 681288003899 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 681288003900 putative nucleotide binding site [chemical binding]; other site 681288003901 putative catalytic residues [active] 681288003902 putative Mg ion binding site [ion binding]; other site 681288003903 putative aspartate binding site [chemical binding]; other site 681288003904 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 681288003905 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 681288003906 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 681288003907 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288003908 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 681288003909 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 681288003910 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 681288003911 dimer interface [polypeptide binding]; other site 681288003912 active site 681288003913 catalytic residue [active] 681288003914 dihydrodipicolinate reductase; Provisional; Region: PRK00048 681288003915 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288003916 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 681288003917 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 681288003918 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 681288003919 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 681288003920 active site 681288003921 trimer interface [polypeptide binding]; other site 681288003922 substrate binding site [chemical binding]; other site 681288003923 CoA binding site [chemical binding]; other site 681288003924 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 681288003925 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 681288003926 metal binding site [ion binding]; metal-binding site 681288003927 dimer interface [polypeptide binding]; other site 681288003928 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 681288003929 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 681288003930 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 681288003931 catalytic residue [active] 681288003932 diaminopimelate decarboxylase; Region: lysA; TIGR01048 681288003933 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 681288003934 active site 681288003935 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 681288003936 substrate binding site [chemical binding]; other site 681288003937 catalytic residues [active] 681288003938 dimer interface [polypeptide binding]; other site 681288003939 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 681288003940 Transposase; Region: DDE_Tnp_ISL3; pfam01610 681288003941 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 681288003942 DNA-binding site [nucleotide binding]; DNA binding site 681288003943 RNA-binding motif; other site 681288003944 Protein of unknown function (DUF1033); Region: DUF1033; cl11549 681288003945 Acylphosphatase; Region: Acylphosphatase; cl00551 681288003946 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 681288003947 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 681288003948 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 681288003949 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 681288003950 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 681288003951 metal ion-dependent adhesion site (MIDAS); other site 681288003952 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 681288003953 Walker A motif; other site 681288003954 ATP binding site [chemical binding]; other site 681288003955 Walker B motif; other site 681288003956 arginine finger; other site 681288003957 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 681288003958 active site 681288003959 metal binding site [ion binding]; metal-binding site 681288003960 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 681288003961 active site 681288003962 metal binding site [ion binding]; metal-binding site 681288003963 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 681288003964 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 681288003965 E3 interaction surface; other site 681288003966 lipoyl attachment site [posttranslational modification]; other site 681288003967 e3 binding domain; Region: E3_binding; pfam02817 681288003968 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 681288003969 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 681288003970 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 681288003971 TPP-binding site [chemical binding]; other site 681288003972 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cl00240 681288003973 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 681288003974 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 681288003975 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 681288003976 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 681288003977 dimer interface [polypeptide binding]; other site 681288003978 phosphorylation site [posttranslational modification] 681288003979 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 681288003980 ATP binding site [chemical binding]; other site 681288003981 G-X-G motif; other site 681288003982 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 681288003983 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 681288003984 active site 681288003985 phosphorylation site [posttranslational modification] 681288003986 intermolecular recognition site; other site 681288003987 dimerization interface [polypeptide binding]; other site 681288003988 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 681288003989 DNA binding site [nucleotide binding] 681288003990 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 681288003991 active site 681288003992 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 681288003993 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 681288003994 active site 681288003995 homodimer interface [polypeptide binding]; other site 681288003996 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 681288003997 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 681288003998 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 681288003999 C-terminal peptidase (prc); Region: prc; TIGR00225 681288004000 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 681288004001 protein binding site [polypeptide binding]; other site 681288004002 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 681288004003 Catalytic dyad [active] 681288004004 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 681288004005 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 681288004006 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 681288004007 HPr interaction site; other site 681288004008 glycerol kinase (GK) interaction site [polypeptide binding]; other site 681288004009 active site 681288004010 phosphorylation site [posttranslational modification] 681288004011 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 681288004012 SelR domain; Region: SelR; pfam01641 681288004013 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 681288004014 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 681288004015 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 681288004016 folate binding site [chemical binding]; other site 681288004017 NADP+ binding site [chemical binding]; other site 681288004018 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 681288004019 dimerization interface [polypeptide binding]; other site 681288004020 active site 681288004021 Disulphide isomerase; Region: Disulph_isomer; pfam06491 681288004022 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 681288004023 Virulence factor; Region: Virulence_fact; pfam13769 681288004024 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 681288004025 HEAT repeat; Region: HEAT; pfam02985 681288004026 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 681288004027 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 681288004028 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 681288004029 RNA/DNA hybrid binding site [nucleotide binding]; other site 681288004030 active site 681288004031 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288004032 GA module; Region: GA; cl08325 681288004033 GA module; Region: GA; cl08325 681288004034 GA module; Region: GA; cl08325 681288004035 GA module; Region: GA; cl08325 681288004036 GA module; Region: GA; cl08325 681288004037 GA module; Region: GA; cl08325 681288004038 GA module; Region: GA; cl08325 681288004039 GA module; Region: GA; cl08325 681288004040 GA module; Region: GA; cl08325 681288004041 GA module; Region: GA; cl08325 681288004042 GA module; Region: GA; cl08325 681288004043 GA module; Region: GA; cl08325 681288004044 GA module; Region: GA; cl08325 681288004045 GA module; Region: GA; cl08325 681288004046 GA module; Region: GA; cl08325 681288004047 GA module; Region: GA; cl08325 681288004048 GA module; Region: GA; cl08325 681288004049 GA module; Region: GA; cl08325 681288004050 GA module; Region: GA; cl08325 681288004051 GA module; Region: GA; cl08325 681288004052 GA module; Region: GA; cl08325 681288004053 GA module; Region: GA; cl08325 681288004054 GA module; Region: GA; cl08325 681288004055 GA module; Region: GA; cl08325 681288004056 GA module; Region: GA; cl08325 681288004057 GA module; Region: GA; cl08325 681288004058 GA module; Region: GA; cl08325 681288004059 chromosome segregation protein; Provisional; Region: PRK02224 681288004060 GA module; Region: GA; cl08325 681288004061 GA module; Region: GA; cl08325 681288004062 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 681288004063 GA module; Region: GA; cl08325 681288004064 GA module; Region: GA; cl08325 681288004065 GA module; Region: GA; cl08325 681288004066 GA module; Region: GA; cl08325 681288004067 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 681288004068 Transmembrane protein; Region: Macoilin; pfam09726 681288004069 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 681288004070 GA module; Region: GA; cl08325 681288004071 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 681288004072 GA module; Region: GA; cl08325 681288004073 GA module; Region: GA; cl08325 681288004074 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 681288004075 GA module; Region: GA; cl08325 681288004076 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 681288004077 GA module; Region: GA; cl08325 681288004078 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 681288004079 GA module; Region: GA; cl08325 681288004080 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 681288004081 GA module; Region: GA; cl08325 681288004082 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 681288004083 GA module; Region: GA; cl08325 681288004084 GA module; Region: GA; cl08325 681288004085 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 681288004086 GA module; Region: GA; cl08325 681288004087 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 681288004088 L-type amino acid transporter; Region: 2A0308; TIGR00911 681288004089 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 681288004090 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 681288004091 tetramer interface [polypeptide binding]; other site 681288004092 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288004093 catalytic residue [active] 681288004094 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 681288004095 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 681288004096 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288004097 5'-3' exonuclease; Region: 53EXOc; smart00475 681288004098 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 681288004099 active site 681288004100 metal binding site 1 [ion binding]; metal-binding site 681288004101 putative 5' ssDNA interaction site; other site 681288004102 metal binding site 3; metal-binding site 681288004103 metal binding site 2 [ion binding]; metal-binding site 681288004104 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 681288004105 putative DNA binding site [nucleotide binding]; other site 681288004106 putative metal binding site [ion binding]; other site 681288004107 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 681288004108 Dynamin family; Region: Dynamin_N; pfam00350 681288004109 G1 box; other site 681288004110 GTP/Mg2+ binding site [chemical binding]; other site 681288004111 G2 box; other site 681288004112 Switch I region; other site 681288004113 G3 box; other site 681288004114 Switch II region; other site 681288004115 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 681288004116 G4 box; other site 681288004117 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288004118 Dynamin family; Region: Dynamin_N; pfam00350 681288004119 G1 box; other site 681288004120 GTP/Mg2+ binding site [chemical binding]; other site 681288004121 G2 box; other site 681288004122 Switch I region; other site 681288004123 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288004124 G3 box; other site 681288004125 Switch II region; other site 681288004126 GTP/Mg2+ binding site [chemical binding]; other site 681288004127 G4 box; other site 681288004128 G5 box; other site 681288004129 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 681288004130 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 681288004131 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 681288004132 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 681288004133 THUMP domain; Region: THUMP; cl12076 681288004134 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288004135 cell division protein GpsB; Provisional; Region: PRK14127 681288004136 DivIVA domain; Region: DivI1A_domain; TIGR03544 681288004137 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 681288004138 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 681288004139 Recombination protein U; Region: RecU; cl01314 681288004140 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 681288004141 Transglycosylase; Region: Transgly; cl07896 681288004142 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 681288004143 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 681288004144 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 681288004145 minor groove reading motif; other site 681288004146 helix-hairpin-helix signature motif; other site 681288004147 substrate binding pocket [chemical binding]; other site 681288004148 active site 681288004149 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 681288004150 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 681288004151 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 681288004152 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 681288004153 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 681288004154 putative dimer interface [polypeptide binding]; other site 681288004155 putative anticodon binding site; other site 681288004156 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 681288004157 homodimer interface [polypeptide binding]; other site 681288004158 motif 1; other site 681288004159 motif 2; other site 681288004160 active site 681288004161 motif 3; other site 681288004162 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 681288004163 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 681288004164 active site 681288004165 catalytic site [active] 681288004166 substrate binding site [chemical binding]; other site 681288004167 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288004168 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288004169 Helix-turn-helix domains; Region: HTH; cl00088 681288004170 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 681288004171 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 681288004172 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 681288004173 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 681288004174 active site 681288004175 NTP binding site [chemical binding]; other site 681288004176 metal binding triad [ion binding]; metal-binding site 681288004177 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 681288004178 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 681288004179 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 681288004180 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 681288004181 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 681288004182 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 681288004183 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 681288004184 Uncharacterized conserved protein [Function unknown]; Region: COG5582 681288004185 UPF0302 domain; Region: UPF0302; pfam08864 681288004186 IDEAL domain; Region: IDEAL; cl07452 681288004187 Vi polysaccharide biosynthesis protein TviE; Provisional; Region: PRK15179 681288004188 TPR repeat; Region: TPR_11; pfam13414 681288004189 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 681288004190 binding surface 681288004191 TPR motif; other site 681288004192 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 681288004193 binding surface 681288004194 TPR motif; other site 681288004195 tetratricopeptide repeat protein; Provisional; Region: PRK11788 681288004196 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 681288004197 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 681288004198 hinge; other site 681288004199 active site 681288004200 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 681288004201 active site 681288004202 NAD binding site [chemical binding]; other site 681288004203 metal binding site [ion binding]; metal-binding site 681288004204 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 681288004205 Tetramer interface [polypeptide binding]; other site 681288004206 active site 681288004207 FMN-binding site [chemical binding]; other site 681288004208 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 681288004209 active site 681288004210 multimer interface [polypeptide binding]; other site 681288004211 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 681288004212 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 681288004213 substrate binding pocket [chemical binding]; other site 681288004214 chain length determination region; other site 681288004215 substrate-Mg2+ binding site; other site 681288004216 catalytic residues [active] 681288004217 aspartate-rich region 1; other site 681288004218 active site lid residues [active] 681288004219 aspartate-rich region 2; other site 681288004220 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 681288004221 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 681288004222 S-adenosylmethionine binding site [chemical binding]; other site 681288004223 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 681288004224 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 681288004225 IHF dimer interface [polypeptide binding]; other site 681288004226 IHF - DNA interface [nucleotide binding]; other site 681288004227 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 681288004228 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288004229 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 681288004230 GTP-binding protein Der; Reviewed; Region: PRK00093 681288004231 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 681288004232 G1 box; other site 681288004233 GTP/Mg2+ binding site [chemical binding]; other site 681288004234 Switch I region; other site 681288004235 G2 box; other site 681288004236 Switch II region; other site 681288004237 G3 box; other site 681288004238 G4 box; other site 681288004239 G5 box; other site 681288004240 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 681288004241 G1 box; other site 681288004242 GTP/Mg2+ binding site [chemical binding]; other site 681288004243 Switch I region; other site 681288004244 G2 box; other site 681288004245 G3 box; other site 681288004246 Switch II region; other site 681288004247 G4 box; other site 681288004248 G5 box; other site 681288004249 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 681288004250 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 681288004251 RNA binding site [nucleotide binding]; other site 681288004252 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 681288004253 RNA binding site [nucleotide binding]; other site 681288004254 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 681288004255 RNA binding site [nucleotide binding]; other site 681288004256 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 681288004257 RNA binding site [nucleotide binding]; other site 681288004258 cytidylate kinase; Provisional; Region: cmk; PRK00023 681288004259 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 681288004260 CMP-binding site; other site 681288004261 The sites determining sugar specificity; other site 681288004262 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 681288004263 active site 681288004264 homotetramer interface [polypeptide binding]; other site 681288004265 homodimer interface [polypeptide binding]; other site 681288004266 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 681288004267 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288004268 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 681288004269 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 681288004270 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 681288004271 ATP binding site [chemical binding]; other site 681288004272 putative Mg++ binding site [ion binding]; other site 681288004273 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 681288004274 nucleotide binding region [chemical binding]; other site 681288004275 ATP-binding site [chemical binding]; other site 681288004276 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 681288004277 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 681288004278 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 681288004279 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 681288004280 SAAV_1473 681288004281 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 681288004282 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 681288004283 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 681288004284 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 681288004285 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 681288004286 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 681288004287 dimerization interface [polypeptide binding]; other site 681288004288 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 681288004289 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 681288004290 dimer interface [polypeptide binding]; other site 681288004291 phosphorylation site [posttranslational modification] 681288004292 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 681288004293 ATP binding site [chemical binding]; other site 681288004294 Mg2+ binding site [ion binding]; other site 681288004295 G-X-G motif; other site 681288004296 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 681288004297 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 681288004298 active site 681288004299 phosphorylation site [posttranslational modification] 681288004300 intermolecular recognition site; other site 681288004301 dimerization interface [polypeptide binding]; other site 681288004302 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 681288004303 DNA binding site [nucleotide binding] 681288004304 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 681288004305 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 681288004306 RNA binding surface [nucleotide binding]; other site 681288004307 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 681288004308 active site 681288004309 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 681288004310 ScpA/B protein; Region: ScpA_ScpB; cl00598 681288004311 Domain of unknown function (DUF309); Region: DUF309; cl00667 681288004312 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 681288004313 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 681288004314 active site 681288004315 Int/Topo IB signature motif; other site 681288004316 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 681288004317 metal binding site 2 [ion binding]; metal-binding site 681288004318 putative DNA binding helix; other site 681288004319 metal binding site 1 [ion binding]; metal-binding site 681288004320 dimer interface [polypeptide binding]; other site 681288004321 structural Zn2+ binding site [ion binding]; other site 681288004322 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 681288004323 dimer interface [polypeptide binding]; other site 681288004324 ADP-ribose binding site [chemical binding]; other site 681288004325 active site 681288004326 nudix motif; other site 681288004327 metal binding site [ion binding]; metal-binding site 681288004328 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 681288004329 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 681288004330 active site 681288004331 catalytic tetrad [active] 681288004332 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 681288004333 classical (c) SDRs; Region: SDR_c; cd05233 681288004334 NAD(P) binding site [chemical binding]; other site 681288004335 active site 681288004336 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288004337 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 681288004338 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 681288004339 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 681288004340 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 681288004341 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 681288004342 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 681288004343 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 681288004344 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 681288004345 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 681288004346 Ca binding site [ion binding]; other site 681288004347 active site 681288004348 catalytic site [active] 681288004349 Transcriptional regulators [Transcription]; Region: PurR; COG1609 681288004350 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 681288004351 DNA binding site [nucleotide binding] 681288004352 domain linker motif; other site 681288004353 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 681288004354 putative ligand binding site [chemical binding]; other site 681288004355 putative dimerization interface [polypeptide binding]; other site 681288004356 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 681288004357 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 681288004358 H+ Antiporter protein; Region: 2A0121; TIGR00900 681288004359 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288004360 putative substrate translocation pore; other site 681288004361 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288004362 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 681288004363 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 681288004364 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 681288004365 peptidase T-like protein; Region: PepT-like; TIGR01883 681288004366 metal binding site [ion binding]; metal-binding site 681288004367 putative dimer interface [polypeptide binding]; other site 681288004368 Predicted membrane protein [Function unknown]; Region: COG4129 681288004369 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 681288004370 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 681288004371 Disulphide isomerase; Region: Disulph_isomer; pfam06491 681288004372 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 681288004373 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 681288004374 E3 interaction surface; other site 681288004375 lipoyl attachment site [posttranslational modification]; other site 681288004376 e3 binding domain; Region: E3_binding; pfam02817 681288004377 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 681288004378 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 681288004379 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 681288004380 alpha subunit interface [polypeptide binding]; other site 681288004381 TPP binding site [chemical binding]; other site 681288004382 heterodimer interface [polypeptide binding]; other site 681288004383 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 681288004384 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 681288004385 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 681288004386 tetramer interface [polypeptide binding]; other site 681288004387 TPP-binding site [chemical binding]; other site 681288004388 heterodimer interface [polypeptide binding]; other site 681288004389 phosphorylation loop region [posttranslational modification] 681288004390 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 681288004391 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288004392 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 681288004393 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 681288004394 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 681288004395 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 681288004396 Walker A/P-loop; other site 681288004397 ATP binding site [chemical binding]; other site 681288004398 Q-loop/lid; other site 681288004399 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 681288004400 Q-loop/lid; other site 681288004401 ABC transporter signature motif; other site 681288004402 Walker B; other site 681288004403 D-loop; other site 681288004404 H-loop/switch region; other site 681288004405 arginine repressor; Provisional; Region: PRK04280 681288004406 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 681288004407 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 681288004408 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 681288004409 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 681288004410 substrate binding pocket [chemical binding]; other site 681288004411 chain length determination region; other site 681288004412 substrate-Mg2+ binding site; other site 681288004413 catalytic residues [active] 681288004414 aspartate-rich region 1; other site 681288004415 active site lid residues [active] 681288004416 aspartate-rich region 2; other site 681288004417 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 681288004418 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 681288004419 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 681288004420 generic binding surface II; other site 681288004421 generic binding surface I; other site 681288004422 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 681288004423 putative RNA binding site [nucleotide binding]; other site 681288004424 Asp23 family; Region: Asp23; cl00574 681288004425 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 681288004426 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 681288004427 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 681288004428 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 681288004429 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 681288004430 carboxyltransferase (CT) interaction site; other site 681288004431 biotinylation site [posttranslational modification]; other site 681288004432 elongation factor P; Validated; Region: PRK00529 681288004433 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 681288004434 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 681288004435 RNA binding site [nucleotide binding]; other site 681288004436 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 681288004437 RNA binding site [nucleotide binding]; other site 681288004438 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 681288004439 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 681288004440 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 681288004441 active site 681288004442 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 681288004443 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 681288004444 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 681288004445 active site residue [active] 681288004446 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 681288004447 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 681288004448 tetramer interface [polypeptide binding]; other site 681288004449 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288004450 catalytic residue [active] 681288004451 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 681288004452 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 681288004453 tetramer interface [polypeptide binding]; other site 681288004454 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288004455 catalytic residue [active] 681288004456 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 681288004457 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 681288004458 SAAV_1530 681288004459 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 681288004460 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 681288004461 ADP binding site [chemical binding]; other site 681288004462 magnesium binding site [ion binding]; other site 681288004463 putative shikimate binding site; other site 681288004464 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 681288004465 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 681288004466 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 681288004467 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 681288004468 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 681288004469 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 681288004470 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 681288004471 Type II/IV secretion system protein; Region: T2SE; pfam00437 681288004472 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288004473 Walker A motif; other site 681288004474 ATP binding site [chemical binding]; other site 681288004475 Walker B motif; other site 681288004476 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 681288004477 Domain of unknown function DUF77; Region: DUF77; cl00307 681288004478 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 681288004479 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 681288004480 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 681288004481 Rhomboid family; Region: Rhomboid; cl11446 681288004482 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 681288004483 binding surface 681288004484 TPR motif; other site 681288004485 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 681288004486 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 681288004487 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 681288004488 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 681288004489 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 681288004490 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 681288004491 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 681288004492 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 681288004493 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 681288004494 metal binding site 2 [ion binding]; metal-binding site 681288004495 putative DNA binding helix; other site 681288004496 metal binding site 1 [ion binding]; metal-binding site 681288004497 dimer interface [polypeptide binding]; other site 681288004498 structural Zn2+ binding site [ion binding]; other site 681288004499 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 681288004500 ABC-ATPase subunit interface; other site 681288004501 dimer interface [polypeptide binding]; other site 681288004502 putative PBP binding regions; other site 681288004503 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 681288004504 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 681288004505 endonuclease IV; Provisional; Region: PRK01060 681288004506 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 681288004507 AP (apurinic/apyrimidinic) site pocket; other site 681288004508 DNA interaction; other site 681288004509 Metal-binding active site; metal-binding site 681288004510 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 681288004511 DEAD-like helicases superfamily; Region: DEXDc; smart00487 681288004512 ATP binding site [chemical binding]; other site 681288004513 Mg++ binding site [ion binding]; other site 681288004514 motif III; other site 681288004515 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 681288004516 nucleotide binding region [chemical binding]; other site 681288004517 ATP-binding site [chemical binding]; other site 681288004518 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 681288004519 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 681288004520 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 681288004521 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288004522 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 681288004523 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 681288004524 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 681288004525 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 681288004526 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 681288004527 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 681288004528 DNA binding residues [nucleotide binding] 681288004529 DNA primase, catalytic core; Region: dnaG; TIGR01391 681288004530 CHC2 zinc finger; Region: zf-CHC2; cl15369 681288004531 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 681288004532 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 681288004533 active site 681288004534 metal binding site [ion binding]; metal-binding site 681288004535 interdomain interaction site; other site 681288004536 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 681288004537 Helix-turn-helix domains; Region: HTH; cl00088 681288004538 FOG: CBS domain [General function prediction only]; Region: COG0517 681288004539 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 681288004540 glycyl-tRNA synthetase; Provisional; Region: PRK04173 681288004541 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 681288004542 motif 1; other site 681288004543 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774 681288004544 active site 681288004545 motif 2; other site 681288004546 motif 3; other site 681288004547 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 681288004548 anticodon binding site; other site 681288004549 DNA repair protein RecO; Region: reco; TIGR00613 681288004550 Recombination protein O N terminal; Region: RecO_N; cl15812 681288004551 Recombination protein O C terminal; Region: RecO_C; pfam02565 681288004552 GTPase Era; Reviewed; Region: era; PRK00089 681288004553 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 681288004554 G1 box; other site 681288004555 GTP/Mg2+ binding site [chemical binding]; other site 681288004556 Switch I region; other site 681288004557 G2 box; other site 681288004558 Switch II region; other site 681288004559 G3 box; other site 681288004560 G4 box; other site 681288004561 G5 box; other site 681288004562 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 681288004563 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 681288004564 active site 681288004565 catalytic motif [active] 681288004566 Zn binding site [ion binding]; other site 681288004567 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 681288004568 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 681288004569 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 681288004570 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288004571 SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057 681288004572 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 681288004573 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 681288004574 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 681288004575 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 681288004576 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 681288004577 FeS/SAM binding site; other site 681288004578 TRAM domain; Region: TRAM; cl01282 681288004579 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 681288004580 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 681288004581 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 681288004582 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 681288004583 S-adenosylmethionine binding site [chemical binding]; other site 681288004584 chaperone protein DnaJ; Provisional; Region: PRK14280 681288004585 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 681288004586 HSP70 interaction site [polypeptide binding]; other site 681288004587 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 681288004588 substrate binding site [polypeptide binding]; other site 681288004589 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 681288004590 Zn binding sites [ion binding]; other site 681288004591 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 681288004592 dimer interface [polypeptide binding]; other site 681288004593 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 681288004594 heat shock protein GrpE; Provisional; Region: PRK14140 681288004595 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 681288004596 dimer interface [polypeptide binding]; other site 681288004597 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 681288004598 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 681288004599 Helix-turn-helix domains; Region: HTH; cl00088 681288004600 HrcA protein C terminal domain; Region: HrcA; pfam01628 681288004601 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 681288004602 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 681288004603 FeS/SAM binding site; other site 681288004604 HemN C-terminal domain; Region: HemN_C; pfam06969 681288004605 GTP-binding protein LepA; Provisional; Region: PRK05433 681288004606 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 681288004607 G1 box; other site 681288004608 putative GEF interaction site [polypeptide binding]; other site 681288004609 GTP/Mg2+ binding site [chemical binding]; other site 681288004610 Switch I region; other site 681288004611 G2 box; other site 681288004612 G3 box; other site 681288004613 Switch II region; other site 681288004614 G4 box; other site 681288004615 G5 box; other site 681288004616 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 681288004617 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 681288004618 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 681288004619 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 681288004620 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 681288004621 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 681288004622 Competence protein; Region: Competence; cl00471 681288004623 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 681288004624 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 681288004625 catalytic motif [active] 681288004626 Zn binding site [ion binding]; other site 681288004627 comEA protein; Region: comE; TIGR01259 681288004628 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 681288004629 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 681288004630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 681288004631 S-adenosylmethionine binding site [chemical binding]; other site 681288004632 Oligomerisation domain; Region: Oligomerisation; cl00519 681288004633 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 681288004634 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 681288004635 Zn2+ binding site [ion binding]; other site 681288004636 Mg2+ binding site [ion binding]; other site 681288004637 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 681288004638 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 681288004639 active site 681288004640 (T/H)XGH motif; other site 681288004641 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 681288004642 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 681288004643 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 681288004644 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 681288004645 shikimate binding site; other site 681288004646 NAD(P) binding site [chemical binding]; other site 681288004647 GTPase YqeH; Provisional; Region: PRK13796 681288004648 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 681288004649 GTP/Mg2+ binding site [chemical binding]; other site 681288004650 G4 box; other site 681288004651 G5 box; other site 681288004652 G1 box; other site 681288004653 Switch I region; other site 681288004654 G2 box; other site 681288004655 G3 box; other site 681288004656 Switch II region; other site 681288004657 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 681288004658 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 681288004659 active site 681288004660 motif I; other site 681288004661 motif II; other site 681288004662 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 681288004663 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288004664 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 681288004665 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 681288004666 LamB/YcsF family; Region: LamB_YcsF; cl00664 681288004667 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 681288004668 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 681288004669 ATP-grasp domain; Region: ATP-grasp_4; cl03087 681288004670 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 681288004671 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 681288004672 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 681288004673 carboxyltransferase (CT) interaction site; other site 681288004674 biotinylation site [posttranslational modification]; other site 681288004675 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 681288004676 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 681288004677 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 681288004678 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 681288004679 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 681288004680 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 681288004681 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 681288004682 Sugar specificity; other site 681288004683 Pyrimidine base specificity; other site 681288004684 ATP-binding site [chemical binding]; other site 681288004685 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 681288004686 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 681288004687 Peptidase family U32; Region: Peptidase_U32; cl03113 681288004688 Peptidase family U32; Region: Peptidase_U32; cl03113 681288004689 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 681288004690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 681288004691 S-adenosylmethionine binding site [chemical binding]; other site 681288004692 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 681288004693 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 681288004694 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 681288004695 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 681288004696 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 681288004697 motif 1; other site 681288004698 active site 681288004699 motif 2; other site 681288004700 motif 3; other site 681288004701 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 681288004702 DHHA1 domain; Region: DHHA1; pfam02272 681288004703 SAAV_1611 681288004704 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 681288004705 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288004706 Family description; Region: UvrD_C_2; cl15862 681288004707 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 681288004708 binding surface 681288004709 TPR motif; other site 681288004710 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 681288004711 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 681288004712 binding surface 681288004713 TPR motif; other site 681288004714 TPR repeat; Region: TPR_11; pfam13414 681288004715 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 681288004716 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 681288004717 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 681288004718 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 681288004719 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 681288004720 catalytic residue [active] 681288004721 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 681288004722 CsbD-like; Region: CsbD; cl15799 681288004723 Predicted transcriptional regulator [Transcription]; Region: COG1959 681288004724 Helix-turn-helix domains; Region: HTH; cl00088 681288004725 recombination factor protein RarA; Reviewed; Region: PRK13342 681288004726 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 681288004727 Walker A motif; other site 681288004728 ATP binding site [chemical binding]; other site 681288004729 Walker B motif; other site 681288004730 arginine finger; other site 681288004731 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 681288004732 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 681288004733 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 681288004734 putative ATP binding site [chemical binding]; other site 681288004735 putative substrate interface [chemical binding]; other site 681288004736 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 681288004737 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 681288004738 dimer interface [polypeptide binding]; other site 681288004739 anticodon binding site; other site 681288004740 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 681288004741 homodimer interface [polypeptide binding]; other site 681288004742 motif 1; other site 681288004743 active site 681288004744 motif 2; other site 681288004745 GAD domain; Region: GAD; pfam02938 681288004746 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 681288004747 motif 3; other site 681288004748 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 681288004749 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 681288004750 dimer interface [polypeptide binding]; other site 681288004751 motif 1; other site 681288004752 active site 681288004753 motif 2; other site 681288004754 motif 3; other site 681288004755 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 681288004756 anticodon binding site; other site 681288004757 Bacterial SH3 domain; Region: SH3_3; cl02551 681288004758 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 681288004759 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 681288004760 active site 681288004761 metal binding site [ion binding]; metal-binding site 681288004762 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 681288004763 putative active site [active] 681288004764 dimerization interface [polypeptide binding]; other site 681288004765 putative tRNAtyr binding site [nucleotide binding]; other site 681288004766 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 681288004767 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 681288004768 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 681288004769 synthetase active site [active] 681288004770 NTP binding site [chemical binding]; other site 681288004771 metal binding site [ion binding]; metal-binding site 681288004772 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 681288004773 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 681288004774 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 681288004775 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 681288004776 active site 681288004777 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 681288004778 DHH family; Region: DHH; pfam01368 681288004779 DHHA1 domain; Region: DHHA1; pfam02272 681288004780 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 681288004781 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 681288004782 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 681288004783 Protein export membrane protein; Region: SecD_SecF; cl14618 681288004784 Protein export membrane protein; Region: SecD_SecF; cl14618 681288004785 Preprotein translocase subunit; Region: YajC; cl00806 681288004786 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 681288004787 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 681288004788 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 681288004789 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 681288004790 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 681288004791 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 681288004792 Walker A motif; other site 681288004793 ATP binding site [chemical binding]; other site 681288004794 Walker B motif; other site 681288004795 arginine finger; other site 681288004796 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 681288004797 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 681288004798 RuvA N terminal domain; Region: RuvA_N; pfam01330 681288004799 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 681288004800 hypothetical protein; Provisional; Region: PRK04435 681288004801 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 681288004802 GTPase CgtA; Reviewed; Region: obgE; PRK12297 681288004803 GTP1/OBG; Region: GTP1_OBG; pfam01018 681288004804 Obg GTPase; Region: Obg; cd01898 681288004805 G1 box; other site 681288004806 GTP/Mg2+ binding site [chemical binding]; other site 681288004807 Switch I region; other site 681288004808 G2 box; other site 681288004809 G3 box; other site 681288004810 Switch II region; other site 681288004811 G4 box; other site 681288004812 G5 box; other site 681288004813 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 681288004814 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 681288004815 Protein of unknown function (DUF464); Region: DUF464; cl01080 681288004816 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 681288004817 rod shape-determining protein MreD; Region: MreD; cl01087 681288004818 rod shape-determining protein MreC; Provisional; Region: PRK13922 681288004819 rod shape-determining protein MreC; Region: MreC; pfam04085 681288004820 hypothetical protein; Reviewed; Region: PRK00024 681288004821 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 681288004822 MPN+ (JAMM) motif; other site 681288004823 Zinc-binding site [ion binding]; other site 681288004824 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 681288004825 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 681288004826 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 681288004827 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 681288004828 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 681288004829 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 681288004830 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 681288004831 active site 681288004832 HIGH motif; other site 681288004833 nucleotide binding site [chemical binding]; other site 681288004834 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 681288004835 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 681288004836 active site 681288004837 KMSKS motif; other site 681288004838 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 681288004839 tRNA binding surface [nucleotide binding]; other site 681288004840 anticodon binding site; other site 681288004841 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 681288004842 SAAV_1650 681288004843 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 681288004844 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 681288004845 Putative ammonia monooxygenase; Region: AmoA; pfam05145 681288004846 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 681288004847 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 681288004848 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 681288004849 inhibitor-cofactor binding pocket; inhibition site 681288004850 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288004851 catalytic residue [active] 681288004852 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 681288004853 dimer interface [polypeptide binding]; other site 681288004854 active site 681288004855 Schiff base residues; other site 681288004856 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 681288004857 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 681288004858 active site 681288004859 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 681288004860 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 681288004861 domain interfaces; other site 681288004862 active site 681288004863 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 681288004864 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 681288004865 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 681288004866 tRNA; other site 681288004867 putative tRNA binding site [nucleotide binding]; other site 681288004868 putative NADP binding site [chemical binding]; other site 681288004869 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 681288004870 Predicted GTPase [General function prediction only]; Region: COG0218 681288004871 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 681288004872 G1 box; other site 681288004873 GTP/Mg2+ binding site [chemical binding]; other site 681288004874 Switch I region; other site 681288004875 G2 box; other site 681288004876 G3 box; other site 681288004877 Switch II region; other site 681288004878 G4 box; other site 681288004879 G5 box; other site 681288004880 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 681288004881 Transposase; Region: DDE_Tnp_ISL3; pfam01610 681288004882 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 681288004883 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 681288004884 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288004885 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 681288004886 trigger factor; Provisional; Region: tig; PRK01490 681288004887 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 681288004888 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 681288004889 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 681288004890 nudix motif; other site 681288004891 ribosomal protein L20; Region: rpl20; CHL00068 681288004892 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 681288004893 23S rRNA binding site [nucleotide binding]; other site 681288004894 L21 binding site [polypeptide binding]; other site 681288004895 L13 binding site [polypeptide binding]; other site 681288004896 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 681288004897 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 681288004898 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 681288004899 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 681288004900 SAAV_1669 681288004901 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 681288004902 SAAV_1671 681288004903 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 681288004904 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 681288004905 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 681288004906 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 681288004907 active site 681288004908 dimer interface [polypeptide binding]; other site 681288004909 motif 1; other site 681288004910 motif 2; other site 681288004911 motif 3; other site 681288004912 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 681288004913 anticodon binding site; other site 681288004914 SAAV_1673 681288004915 primosomal protein DnaI; Reviewed; Region: PRK08939 681288004916 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 681288004917 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 681288004918 Walker A motif; other site 681288004919 ATP binding site [chemical binding]; other site 681288004920 Walker B motif; other site 681288004921 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 681288004922 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 681288004923 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 681288004924 ATP cone domain; Region: ATP-cone; pfam03477 681288004925 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 681288004926 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288004927 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 681288004928 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 681288004929 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 681288004930 CoA-binding site [chemical binding]; other site 681288004931 ATP-binding [chemical binding]; other site 681288004932 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 681288004933 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 681288004934 DNA binding site [nucleotide binding] 681288004935 catalytic residue [active] 681288004936 H2TH interface [polypeptide binding]; other site 681288004937 putative catalytic residues [active] 681288004938 turnover-facilitating residue; other site 681288004939 intercalation triad [nucleotide binding]; other site 681288004940 8OG recognition residue [nucleotide binding]; other site 681288004941 putative reading head residues; other site 681288004942 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 681288004943 DNA polymerase I; Provisional; Region: PRK05755 681288004944 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 681288004945 active site 681288004946 metal binding site 1 [ion binding]; metal-binding site 681288004947 putative 5' ssDNA interaction site; other site 681288004948 metal binding site 3; metal-binding site 681288004949 metal binding site 2 [ion binding]; metal-binding site 681288004950 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 681288004951 putative DNA binding site [nucleotide binding]; other site 681288004952 putative metal binding site [ion binding]; other site 681288004953 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 681288004954 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 681288004955 active site 681288004956 DNA binding site [nucleotide binding] 681288004957 catalytic site [active] 681288004958 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 681288004959 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 681288004960 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 681288004961 dimer interface [polypeptide binding]; other site 681288004962 phosphorylation site [posttranslational modification] 681288004963 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 681288004964 ATP binding site [chemical binding]; other site 681288004965 Mg2+ binding site [ion binding]; other site 681288004966 G-X-G motif; other site 681288004967 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 681288004968 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 681288004969 active site 681288004970 phosphorylation site [posttranslational modification] 681288004971 intermolecular recognition site; other site 681288004972 dimerization interface [polypeptide binding]; other site 681288004973 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 681288004974 DNA binding site [nucleotide binding] 681288004975 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 681288004976 isocitrate dehydrogenase; Validated; Region: PRK07362 681288004977 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 681288004978 dimer interface [polypeptide binding]; other site 681288004979 Citrate synthase; Region: Citrate_synt; pfam00285 681288004980 active site 681288004981 citrylCoA binding site [chemical binding]; other site 681288004982 oxalacetate/citrate binding site [chemical binding]; other site 681288004983 coenzyme A binding site [chemical binding]; other site 681288004984 catalytic triad [active] 681288004985 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 681288004986 pyruvate kinase; Provisional; Region: PRK06354 681288004987 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 681288004988 domain interfaces; other site 681288004989 active site 681288004990 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 681288004991 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 681288004992 active site 681288004993 ADP/pyrophosphate binding site [chemical binding]; other site 681288004994 dimerization interface [polypeptide binding]; other site 681288004995 allosteric effector site; other site 681288004996 fructose-1,6-bisphosphate binding site; other site 681288004997 Integrase core domain; Region: rve; cl01316 681288004998 Integrase core domain; Region: rve_3; cl15866 681288004999 Helix-turn-helix domains; Region: HTH; cl00088 681288005000 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 681288005001 Helix-turn-helix domains; Region: HTH; cl00088 681288005002 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 681288005003 NlpC/P60 family; Region: NLPC_P60; cl11438 681288005004 Cenp-F N-terminal domain; Region: Cenp-F_N; pfam10481 681288005005 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288005006 AAA-like domain; Region: AAA_10; pfam12846 681288005007 TcpE family; Region: TcpE; pfam12648 681288005008 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 681288005009 Replication initiation factor; Region: Rep_trans; pfam02486 681288005010 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 681288005011 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 681288005012 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 681288005013 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 681288005014 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 681288005015 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 681288005016 Malic enzyme, N-terminal domain; Region: malic; pfam00390 681288005017 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 681288005018 putative NAD(P) binding site [chemical binding]; other site 681288005019 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 681288005020 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 681288005021 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 681288005022 generic binding surface I; other site 681288005023 generic binding surface II; other site 681288005024 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 681288005025 DHH family; Region: DHH; pfam01368 681288005026 DHHA1 domain; Region: DHHA1; pfam02272 681288005027 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 681288005028 Helix-turn-helix domains; Region: HTH; cl00088 681288005029 DNA-binding site [nucleotide binding]; DNA binding site 681288005030 DRTGG domain; Region: DRTGG; cl12147 681288005031 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 681288005032 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 681288005033 Ligand Binding Site [chemical binding]; other site 681288005034 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 681288005035 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 681288005036 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 681288005037 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 681288005038 active site 681288005039 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 681288005040 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 681288005041 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288005042 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 681288005043 Ligand Binding Site [chemical binding]; other site 681288005044 Acetokinase family; Region: Acetate_kinase; cl01029 681288005045 propionate/acetate kinase; Provisional; Region: PRK12379 681288005046 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 681288005047 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288005048 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 681288005049 dimer interface [polypeptide binding]; other site 681288005050 catalytic triad [active] 681288005051 peroxidatic and resolving cysteines [active] 681288005052 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 681288005053 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 681288005054 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 681288005055 THUMP domain; Region: THUMP; cl12076 681288005056 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 681288005057 Ligand Binding Site [chemical binding]; other site 681288005058 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 681288005059 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 681288005060 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 681288005061 catalytic residue [active] 681288005062 septation ring formation regulator EzrA; Provisional; Region: PRK04778 681288005063 GAF domain; Region: GAF; cl15785 681288005064 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 681288005065 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 681288005066 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 681288005067 RNA binding surface [nucleotide binding]; other site 681288005068 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 681288005069 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 681288005070 active site 681288005071 catalytic site [active] 681288005072 OsmC-like protein; Region: OsmC; cl00767 681288005073 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 681288005074 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 681288005075 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 681288005076 catalytic residue [active] 681288005077 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 681288005078 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288005079 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 681288005080 putative L-serine binding site [chemical binding]; other site 681288005081 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 681288005082 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 681288005083 motif II; other site 681288005084 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 681288005085 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 681288005086 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 681288005087 active site turn [active] 681288005088 phosphorylation site [posttranslational modification] 681288005089 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 681288005090 putative acyl-acceptor binding pocket; other site 681288005091 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 681288005092 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 681288005093 protein binding site [polypeptide binding]; other site 681288005094 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 681288005095 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 681288005096 active site 681288005097 HIGH motif; other site 681288005098 dimer interface [polypeptide binding]; other site 681288005099 KMSKS motif; other site 681288005100 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 681288005101 RNA binding surface [nucleotide binding]; other site 681288005102 Transglycosylase; Region: Transgly; cl07896 681288005103 haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658 681288005104 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 681288005105 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cl02760 681288005106 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cl02760 681288005107 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 681288005108 heme-binding site [chemical binding]; other site 681288005109 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 681288005110 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 681288005111 Potassium binding sites [ion binding]; other site 681288005112 Cesium cation binding sites [ion binding]; other site 681288005113 acetyl-CoA synthetase; Provisional; Region: PRK04319 681288005114 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 681288005115 AMP-binding enzyme; Region: AMP-binding; cl15778 681288005116 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 681288005117 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 681288005118 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 681288005119 catabolite control protein A; Region: ccpA; TIGR01481 681288005120 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 681288005121 DNA binding site [nucleotide binding] 681288005122 domain linker motif; other site 681288005123 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 681288005124 dimerization interface [polypeptide binding]; other site 681288005125 effector binding site; other site 681288005126 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 681288005127 Chorismate mutase type II; Region: CM_2; cl00693 681288005128 NeuB family; Region: NeuB; cl00496 681288005129 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 681288005130 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 681288005131 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 681288005132 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 681288005133 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 681288005134 Ring-infected erythrocyte surface antigen; Provisional; Region: PTZ00341 681288005135 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288005136 HerA helicase [Replication, recombination, and repair]; Region: COG0433 681288005137 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 681288005138 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 681288005139 putative tRNA-binding site [nucleotide binding]; other site 681288005140 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 681288005141 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 681288005142 catalytic residues [active] 681288005143 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 681288005144 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 681288005145 oligomer interface [polypeptide binding]; other site 681288005146 active site 681288005147 metal binding site [ion binding]; metal-binding site 681288005148 Predicted small secreted protein [Function unknown]; Region: COG5584 681288005149 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 681288005150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 681288005151 Phosphotransferase enzyme family; Region: APH; pfam01636 681288005152 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 681288005153 substrate binding site [chemical binding]; other site 681288005154 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 681288005155 homodimer interface [polypeptide binding]; other site 681288005156 substrate-cofactor binding pocket; other site 681288005157 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288005158 catalytic residue [active] 681288005159 dipeptidase PepV; Reviewed; Region: PRK07318 681288005160 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 681288005161 active site 681288005162 metal binding site [ion binding]; metal-binding site 681288005163 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 681288005164 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 681288005165 RNA binding surface [nucleotide binding]; other site 681288005166 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 681288005167 active site 681288005168 uracil binding [chemical binding]; other site 681288005169 MatE; Region: MatE; cl10513 681288005170 stage V sporulation protein B; Region: spore_V_B; TIGR02900 681288005171 MatE; Region: MatE; cl10513 681288005172 HI0933-like protein; Region: HI0933_like; pfam03486 681288005173 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288005174 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 681288005175 cytoskeletal protein RodZ; Provisional; Region: PRK10856 681288005176 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288005177 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288005178 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288005179 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288005180 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288005181 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288005182 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288005183 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288005184 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288005185 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288005186 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288005187 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288005188 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288005189 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288005190 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288005191 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288005192 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 681288005193 active site residue [active] 681288005194 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 681288005195 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 681288005196 HIGH motif; other site 681288005197 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 681288005198 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 681288005199 active site 681288005200 KMSKS motif; other site 681288005201 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 681288005202 tRNA binding surface [nucleotide binding]; other site 681288005203 SAAV_1769 681288005204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288005205 Major Facilitator Superfamily; Region: MFS_1; pfam07690 681288005206 putative substrate translocation pore; other site 681288005207 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 681288005208 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288005209 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288005210 Helix-turn-helix domains; Region: HTH; cl00088 681288005211 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 681288005212 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 681288005213 Proline dehydrogenase; Region: Pro_dh; cl03282 681288005214 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 681288005215 homopentamer interface [polypeptide binding]; other site 681288005216 active site 681288005217 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 681288005218 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 681288005219 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 681288005220 dimerization interface [polypeptide binding]; other site 681288005221 active site 681288005222 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 681288005223 Lumazine binding domain; Region: Lum_binding; pfam00677 681288005224 Lumazine binding domain; Region: Lum_binding; pfam00677 681288005225 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 681288005226 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 681288005227 catalytic motif [active] 681288005228 Zn binding site [ion binding]; other site 681288005229 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 681288005230 SAAV_1781 681288005231 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 681288005232 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288005233 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 681288005234 dimerization interface [polypeptide binding]; other site 681288005235 putative DNA binding site [nucleotide binding]; other site 681288005236 putative Zn2+ binding site [ion binding]; other site 681288005237 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 681288005238 arsenical pump membrane protein; Provisional; Region: PRK15445 681288005239 transmembrane helices; other site 681288005240 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 681288005241 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 681288005242 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 681288005243 Helix-turn-helix domains; Region: HTH; cl00088 681288005244 DNA binding residues [nucleotide binding] 681288005245 CAAX protease self-immunity; Region: Abi; cl00558 681288005246 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 681288005247 active site 681288005248 intersubunit interactions; other site 681288005249 catalytic residue [active] 681288005250 CrcB-like protein; Region: CRCB; cl09114 681288005251 CrcB-like protein; Region: CRCB; cl09114 681288005252 Transposase domain (DUF772); Region: DUF772; cl15789 681288005253 Transposase domain (DUF772); Region: DUF772; cl15789 681288005254 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 681288005255 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 681288005256 active site 681288005257 catalytic tetrad [active] 681288005258 S-adenosylmethionine synthetase; Validated; Region: PRK05250 681288005259 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 681288005260 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 681288005261 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 681288005262 SAAV_1800 681288005263 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 681288005264 active site 681288005265 substrate-binding site [chemical binding]; other site 681288005266 metal-binding site [ion binding] 681288005267 ATP binding site [chemical binding]; other site 681288005268 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 681288005269 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 681288005270 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 681288005271 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 681288005272 nudix motif; other site 681288005273 Haemolytic domain; Region: Haemolytic; cl00506 681288005274 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 681288005275 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 681288005276 metal binding site [ion binding]; metal-binding site 681288005277 substrate binding pocket [chemical binding]; other site 681288005278 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 681288005279 AMP-binding enzyme; Region: AMP-binding; cl15778 681288005280 Excalibur calcium-binding domain; Region: Excalibur; cl05460 681288005281 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 681288005282 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 681288005283 Integrase core domain; Region: rve; cl01316 681288005284 DDE domain; Region: DDE_Tnp_IS240; pfam13610 681288005285 Integrase core domain; Region: rve_3; cl15866 681288005286 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 681288005287 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 681288005288 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 681288005289 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 681288005290 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 681288005291 HsdM N-terminal domain; Region: HsdM_N; pfam12161 681288005292 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288005293 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 681288005294 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 681288005295 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 681288005296 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 681288005297 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 681288005298 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 681288005299 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 681288005300 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 681288005301 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 681288005302 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 681288005303 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 681288005304 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 681288005305 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 681288005306 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 681288005307 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288005308 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 681288005309 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288005310 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288005311 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 681288005312 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 681288005313 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288005314 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 681288005315 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288005316 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 681288005317 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 681288005318 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 681288005319 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 681288005320 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 681288005321 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288005322 ferrochelatase; Provisional; Region: PRK12435 681288005323 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 681288005324 C-terminal domain interface [polypeptide binding]; other site 681288005325 active site 681288005326 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 681288005327 active site 681288005328 N-terminal domain interface [polypeptide binding]; other site 681288005329 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 681288005330 methyltransferase, MtaA/CmuA family; Region: mtaA_cmuA; TIGR01463 681288005331 substrate binding site [chemical binding]; other site 681288005332 active site 681288005333 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 681288005334 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 681288005335 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 681288005336 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 681288005337 Walker A/P-loop; other site 681288005338 ATP binding site [chemical binding]; other site 681288005339 Q-loop/lid; other site 681288005340 ABC transporter signature motif; other site 681288005341 Walker B; other site 681288005342 D-loop; other site 681288005343 H-loop/switch region; other site 681288005344 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 681288005345 HIT family signature motif; other site 681288005346 catalytic residue [active] 681288005347 YtxH-like protein; Region: YtxH; cl02079 681288005348 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 681288005349 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 681288005350 SurA N-terminal domain; Region: SurA_N_3; cl07813 681288005351 PPIC-type PPIASE domain; Region: Rotamase; cl08278 681288005352 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 681288005353 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 681288005354 generic binding surface II; other site 681288005355 generic binding surface I; other site 681288005356 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 681288005357 Zn2+ binding site [ion binding]; other site 681288005358 Mg2+ binding site [ion binding]; other site 681288005359 Uncharacterized conserved protein [Function unknown]; Region: COG4717 681288005360 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288005361 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 681288005362 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 681288005363 active site 681288005364 metal binding site [ion binding]; metal-binding site 681288005365 DNA binding site [nucleotide binding] 681288005366 Protein of unknown function (DUF964); Region: DUF964; cl01483 681288005367 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 681288005368 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 681288005369 non-specific DNA binding site [nucleotide binding]; other site 681288005370 salt bridge; other site 681288005371 sequence-specific DNA binding site [nucleotide binding]; other site 681288005372 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 681288005373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 681288005374 active site 681288005375 phosphorylation site [posttranslational modification] 681288005376 intermolecular recognition site; other site 681288005377 dimerization interface [polypeptide binding]; other site 681288005378 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 681288005379 DNA binding residues [nucleotide binding] 681288005380 dimerization interface [polypeptide binding]; other site 681288005381 GAF domain; Region: GAF_2; pfam13185 681288005382 GAF domain; Region: GAF; cl15785 681288005383 Histidine kinase; Region: HisKA_3; pfam07730 681288005384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 681288005385 ATP binding site [chemical binding]; other site 681288005386 Mg2+ binding site [ion binding]; other site 681288005387 G-X-G motif; other site 681288005388 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 681288005389 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 681288005390 active site 681288005391 fumarate hydratase; Reviewed; Region: fumC; PRK00485 681288005392 Class II fumarases; Region: Fumarase_classII; cd01362 681288005393 active site 681288005394 tetramer interface [polypeptide binding]; other site 681288005395 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 681288005396 active site 681288005397 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 681288005398 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 681288005399 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 681288005400 HEAT repeats; Region: HEAT_2; pfam13646 681288005401 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 681288005402 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 681288005403 Walker A/P-loop; other site 681288005404 ATP binding site [chemical binding]; other site 681288005405 Q-loop/lid; other site 681288005406 ABC transporter signature motif; other site 681288005407 Walker B; other site 681288005408 D-loop; other site 681288005409 H-loop/switch region; other site 681288005410 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 681288005411 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 681288005412 substrate binding pocket [chemical binding]; other site 681288005413 membrane-bound complex binding site; other site 681288005414 hinge residues; other site 681288005415 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 681288005416 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288005417 dimer interface [polypeptide binding]; other site 681288005418 conserved gate region; other site 681288005419 putative PBP binding loops; other site 681288005420 ABC-ATPase subunit interface; other site 681288005421 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 681288005422 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 681288005423 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 681288005424 Transposase; Region: DDE_Tnp_ISL3; pfam01610 681288005425 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 681288005426 metal binding site 2 [ion binding]; metal-binding site 681288005427 putative DNA binding helix; other site 681288005428 metal binding site 1 [ion binding]; metal-binding site 681288005429 dimer interface [polypeptide binding]; other site 681288005430 structural Zn2+ binding site [ion binding]; other site 681288005431 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 681288005432 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288005433 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 681288005434 catalytic triad [active] 681288005435 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 681288005436 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 681288005437 inhibitor-cofactor binding pocket; inhibition site 681288005438 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288005439 catalytic residue [active] 681288005440 Predicted membrane protein [Function unknown]; Region: COG4129 681288005441 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 681288005442 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 681288005443 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 681288005444 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 681288005445 Walker A/P-loop; other site 681288005446 ATP binding site [chemical binding]; other site 681288005447 Q-loop/lid; other site 681288005448 ABC transporter signature motif; other site 681288005449 Walker B; other site 681288005450 D-loop; other site 681288005451 H-loop/switch region; other site 681288005452 Protein of unknown function (DUF402); Region: DUF402; cl00979 681288005453 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 681288005454 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 681288005455 minor groove reading motif; other site 681288005456 helix-hairpin-helix signature motif; other site 681288005457 substrate binding pocket [chemical binding]; other site 681288005458 active site 681288005459 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 681288005460 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 681288005461 DNA binding and oxoG recognition site [nucleotide binding] 681288005462 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 681288005463 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 681288005464 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288005465 Walker A/P-loop; other site 681288005466 ATP binding site [chemical binding]; other site 681288005467 Q-loop/lid; other site 681288005468 ABC transporter signature motif; other site 681288005469 Walker B; other site 681288005470 D-loop; other site 681288005471 H-loop/switch region; other site 681288005472 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 681288005473 RecX family; Region: RecX; cl00936 681288005474 Transglycosylase; Region: Transgly; cl07896 681288005475 intracellular protease, PfpI family; Region: PfpI; TIGR01382 681288005476 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 681288005477 proposed catalytic triad [active] 681288005478 conserved cys residue [active] 681288005479 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 681288005480 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 681288005481 FeS/SAM binding site; other site 681288005482 YfkB-like domain; Region: YfkB; pfam08756 681288005483 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 681288005484 Replication initiation factor; Region: Rep_trans; pfam02486 681288005485 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 681288005486 TcpE family; Region: TcpE; pfam12648 681288005487 AAA-like domain; Region: AAA_10; pfam12846 681288005488 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288005489 ribonuclease E; Reviewed; Region: rne; PRK10811 681288005490 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 681288005491 Surface antigen [General function prediction only]; Region: COG3942 681288005492 NlpC/P60 family; Region: NLPC_P60; cl11438 681288005493 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 681288005494 Helix-turn-helix domains; Region: HTH; cl00088 681288005495 Integrase core domain; Region: rve; cl01316 681288005496 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 681288005497 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 681288005498 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 681288005499 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 681288005500 Low molecular weight phosphatase family; Region: LMWPc; cd00115 681288005501 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 681288005502 active site 681288005503 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 681288005504 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 681288005505 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 681288005506 active site 681288005507 phosphorylation site [posttranslational modification] 681288005508 intermolecular recognition site; other site 681288005509 dimerization interface [polypeptide binding]; other site 681288005510 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 681288005511 DNA binding residues [nucleotide binding] 681288005512 dimerization interface [polypeptide binding]; other site 681288005513 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 681288005514 Histidine kinase; Region: HisKA_3; pfam07730 681288005515 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 681288005516 ATP binding site [chemical binding]; other site 681288005517 Mg2+ binding site [ion binding]; other site 681288005518 G-X-G motif; other site 681288005519 Predicted membrane protein [Function unknown]; Region: COG4758 681288005520 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 681288005521 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 681288005522 active site 681288005523 Predicted membrane protein [Function unknown]; Region: COG4129 681288005524 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 681288005525 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 681288005526 catalytic triad [active] 681288005527 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 681288005528 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 681288005529 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 681288005530 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 681288005531 Ferritin-like domain; Region: Ferritin; pfam00210 681288005532 ferroxidase diiron center [ion binding]; other site 681288005533 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 681288005534 active site 681288005535 catalytic site [active] 681288005536 substrate binding site [chemical binding]; other site 681288005537 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 681288005538 active site 681288005539 DNA polymerase IV; Validated; Region: PRK02406 681288005540 DNA binding site [nucleotide binding] 681288005541 TRAM domain; Region: TRAM; cl01282 681288005542 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 681288005543 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 681288005544 S-adenosylmethionine binding site [chemical binding]; other site 681288005545 putative lipid kinase; Reviewed; Region: PRK13337 681288005546 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 681288005547 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 681288005548 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 681288005549 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 681288005550 GatB domain; Region: GatB_Yqey; cl11497 681288005551 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 681288005552 Amidase; Region: Amidase; cl11426 681288005553 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 681288005554 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 681288005555 Sodium:solute symporter family; Region: SSF; cl00456 681288005556 CamS sex pheromone cAM373 precursor; Region: CamS; cl11554 681288005557 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 681288005558 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 681288005559 nucleotide binding pocket [chemical binding]; other site 681288005560 K-X-D-G motif; other site 681288005561 catalytic site [active] 681288005562 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 681288005563 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 681288005564 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 681288005565 Dimer interface [polypeptide binding]; other site 681288005566 BRCT sequence motif; other site 681288005567 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 681288005568 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288005569 Family description; Region: UvrD_C_2; cl15862 681288005570 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 681288005571 substrate binding site [chemical binding]; other site 681288005572 putative active site [active] 681288005573 dimer interface [polypeptide binding]; other site 681288005574 Helix-turn-helix domains; Region: HTH; cl00088 681288005575 adenylosuccinate lyase; Provisional; Region: PRK07492 681288005576 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 681288005577 tetramer interface [polypeptide binding]; other site 681288005578 active site 681288005579 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 681288005580 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 681288005581 Staphostatin A; Region: Staphostatin_A; pfam09022 681288005582 NETI protein; Region: NETI; pfam14044 681288005583 hypothetical protein; Provisional; Region: PRK04164 681288005584 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 681288005585 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 681288005586 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 681288005587 homodimer interface [polypeptide binding]; other site 681288005588 NAD binding pocket [chemical binding]; other site 681288005589 ATP binding pocket [chemical binding]; other site 681288005590 Mg binding site [ion binding]; other site 681288005591 active-site loop [active] 681288005592 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 681288005593 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 681288005594 active site 681288005595 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 681288005596 active site 681288005597 dimer interface [polypeptide binding]; other site 681288005598 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 681288005599 Prephenate dehydratase; Region: PDT; pfam00800 681288005600 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 681288005601 putative L-Phe binding site [chemical binding]; other site 681288005602 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 681288005603 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 681288005604 transmembrane helices; other site 681288005605 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 681288005606 Isochorismatase family; Region: Isochorismatase; pfam00857 681288005607 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 681288005608 catalytic triad [active] 681288005609 conserved cis-peptide bond; other site 681288005610 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 681288005611 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 681288005612 DHHA2 domain; Region: DHHA2; pfam02833 681288005613 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 681288005614 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 681288005615 NAD(P) binding site [chemical binding]; other site 681288005616 catalytic residues [active] 681288005617 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 681288005618 YolD-like protein; Region: YolD; pfam08863 681288005619 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 681288005620 active site 681288005621 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 681288005622 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 681288005623 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 681288005624 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 681288005625 Walker A/P-loop; other site 681288005626 ATP binding site [chemical binding]; other site 681288005627 Q-loop/lid; other site 681288005628 ABC transporter signature motif; other site 681288005629 Walker B; other site 681288005630 D-loop; other site 681288005631 H-loop/switch region; other site 681288005632 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 681288005633 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 681288005634 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 681288005635 Walker A/P-loop; other site 681288005636 ATP binding site [chemical binding]; other site 681288005637 Q-loop/lid; other site 681288005638 ABC transporter signature motif; other site 681288005639 Walker B; other site 681288005640 D-loop; other site 681288005641 H-loop/switch region; other site 681288005642 Predicted transcriptional regulators [Transcription]; Region: COG1725 681288005643 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 681288005644 DNA-binding site [nucleotide binding]; DNA binding site 681288005645 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 681288005646 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 681288005647 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288005648 homodimer interface [polypeptide binding]; other site 681288005649 catalytic residue [active] 681288005650 MAP domain; Region: MAP; pfam03642 681288005651 MAP domain; Region: MAP; pfam03642 681288005652 MAP domain; Region: MAP; pfam03642 681288005653 MAP domain; Region: MAP; pfam03642 681288005654 MAP domain; Region: MAP; pfam03642 681288005655 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 681288005656 ornithine cyclodeaminase; Validated; Region: PRK08618 681288005657 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288005658 CAAX protease self-immunity; Region: Abi; cl00558 681288005659 NlpC/P60 family; Region: NLPC_P60; cl11438 681288005660 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 681288005661 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 681288005662 active site 681288005663 metal binding site [ion binding]; metal-binding site 681288005664 Bacterial SH3 domain; Region: SH3_3; cl02551 681288005665 Phage lysis protein, holin; Region: Phage_holin; cl04675 681288005666 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 681288005667 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 681288005668 Protein of unknown function (DUF2977); Region: DUF2977; pfam11192 681288005669 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 681288005670 hypothetical protein; Provisional; Region: PRK05926 681288005671 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 681288005672 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 681288005673 Phage tail protein; Region: Sipho_tail; pfam05709 681288005674 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cd00176 681288005675 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 681288005676 linker region; other site 681288005677 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 681288005678 hypothetical protein; Provisional; Region: PHA02937 681288005679 Peptidase family M23; Region: Peptidase_M23; pfam01551 681288005680 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 681288005681 N-acetyl-D-glucosamine binding site [chemical binding]; other site 681288005682 catalytic residue [active] 681288005683 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 681288005684 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 681288005685 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 681288005686 oligomerization interface [polypeptide binding]; other site 681288005687 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 681288005688 Phage capsid family; Region: Phage_capsid; pfam05065 681288005689 Clp protease; Region: CLP_protease; pfam00574 681288005690 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 681288005691 oligomer interface [polypeptide binding]; other site 681288005692 active site residues [active] 681288005693 Phage-related protein [Function unknown]; Region: COG4695; cl01923 681288005694 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 681288005695 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 681288005696 Phage Terminase; Region: Terminase_1; pfam03354 681288005697 Phage terminase, small subunit; Region: Terminase_4; cl01525 681288005698 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 681288005699 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 681288005700 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 681288005701 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 681288005702 Dimeric dUTPase [Carbohydrate transport and metabolism]; Region: COG4508 681288005703 dUTPase; Region: dUTPase_2; pfam08761 681288005704 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 681288005705 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 681288005706 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 681288005707 Protein of unknown function (DUF3113); Region: DUF3113; pfam11310 681288005708 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 681288005709 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 681288005710 DNA polymerase elongation subunit (family B) [DNA replication, recombination, and repair]; Region: PolB; COG0417 681288005711 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both synthetic; Region: POLBc; cl10023 681288005712 active site 681288005713 metal-binding site 681288005714 Protein of unknown function (DUF1351); Region: DUF1351; pfam07083 681288005715 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 681288005716 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 681288005717 Protein of unknown function (DUF1270); Region: DUF1270; pfam06900 681288005718 Domain of unknown function (DUF771); Region: DUF771; cl09962 681288005719 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 681288005720 non-specific DNA binding site [nucleotide binding]; other site 681288005721 salt bridge; other site 681288005722 sequence-specific DNA binding site [nucleotide binding]; other site 681288005723 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 681288005724 non-specific DNA binding site [nucleotide binding]; other site 681288005725 salt bridge; other site 681288005726 sequence-specific DNA binding site [nucleotide binding]; other site 681288005727 Domain of unknown function (DUF955); Region: DUF955; cl01076 681288005728 PemK-like protein; Region: PemK; cl00995 681288005729 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 681288005730 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 681288005731 Int/Topo IB signature motif; other site 681288005732 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 681288005733 putative catalytic site [active] 681288005734 phosphate binding site [ion binding]; other site 681288005735 metal binding site A [ion binding]; metal-binding site 681288005736 metal binding site C [ion binding]; metal-binding site 681288005737 metal binding site B [ion binding]; metal-binding site 681288005738 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 681288005739 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 681288005740 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 681288005741 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 681288005742 metal binding site [ion binding]; metal-binding site 681288005743 dimer interface [polypeptide binding]; other site 681288005744 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 681288005745 Cation transport protein; Region: TrkH; cl10514 681288005746 Cation transport protein; Region: TrkH; cl10514 681288005747 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 681288005748 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 681288005749 ring oligomerisation interface [polypeptide binding]; other site 681288005750 ATP/Mg binding site [chemical binding]; other site 681288005751 stacking interactions; other site 681288005752 hinge regions; other site 681288005753 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 681288005754 oligomerisation interface [polypeptide binding]; other site 681288005755 mobile loop; other site 681288005756 roof hairpin; other site 681288005757 CAAX protease self-immunity; Region: Abi; cl00558 681288005758 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 681288005759 dimer interface [polypeptide binding]; other site 681288005760 FMN binding site [chemical binding]; other site 681288005761 Predicted amidohydrolase [General function prediction only]; Region: COG0388 681288005762 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 681288005763 putative active site [active] 681288005764 catalytic triad [active] 681288005765 putative dimer interface [polypeptide binding]; other site 681288005766 delta-hemolysin; Provisional; Region: PRK14752 681288005767 Accessory gene regulator B; Region: AgrB; cl01873 681288005768 Staphylococcal AgrD protein; Region: AgrD; cl05477 681288005769 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 681288005770 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 681288005771 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 681288005772 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 681288005773 active site 681288005774 phosphorylation site [posttranslational modification] 681288005775 intermolecular recognition site; other site 681288005776 dimerization interface [polypeptide binding]; other site 681288005777 LytTr DNA-binding domain; Region: LytTR; cl04498 681288005778 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 681288005779 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 681288005780 putative substrate binding site [chemical binding]; other site 681288005781 putative ATP binding site [chemical binding]; other site 681288005782 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 681288005783 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 681288005784 substrate binding [chemical binding]; other site 681288005785 active site 681288005786 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 681288005787 Transcriptional regulators [Transcription]; Region: PurR; COG1609 681288005788 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 681288005789 DNA binding site [nucleotide binding] 681288005790 domain linker motif; other site 681288005791 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 681288005792 dimerization interface [polypeptide binding]; other site 681288005793 ligand binding site [chemical binding]; other site 681288005794 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 681288005795 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 681288005796 CPxP motif; other site 681288005797 Sulphur transport; Region: Sulf_transp; cl01018 681288005798 Sulphur transport; Region: Sulf_transp; cl01018 681288005799 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 681288005800 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 681288005801 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288005802 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 681288005803 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 681288005804 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 681288005805 ABC transporter; Region: ABC_tran_2; pfam12848 681288005806 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 681288005807 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 681288005808 MutS-like homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess...; Region: ABC_MutS-like; cd03283 681288005809 Walker A/P-loop; other site 681288005810 ATP binding site [chemical binding]; other site 681288005811 Q-loop/lid; other site 681288005812 ABC transporter signature motif; other site 681288005813 Walker B; other site 681288005814 D-loop; other site 681288005815 H-loop/switch region; other site 681288005816 UGMP family protein; Validated; Region: PRK09604 681288005817 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 681288005818 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 681288005819 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 681288005820 Coenzyme A binding pocket [chemical binding]; other site 681288005821 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 681288005822 Glycoprotease family; Region: Peptidase_M22; pfam00814 681288005823 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 681288005824 Dehydratase family; Region: ILVD_EDD; cl00340 681288005825 6-phosphogluconate dehydratase; Region: edd; TIGR01196 681288005826 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 681288005827 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 681288005828 PYR/PP interface [polypeptide binding]; other site 681288005829 dimer interface [polypeptide binding]; other site 681288005830 TPP binding site [chemical binding]; other site 681288005831 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 681288005832 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 681288005833 TPP-binding site [chemical binding]; other site 681288005834 dimer interface [polypeptide binding]; other site 681288005835 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 681288005836 ketol-acid reductoisomerase; Provisional; Region: PRK05479 681288005837 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288005838 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 681288005839 2-isopropylmalate synthase; Validated; Region: PRK00915 681288005840 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 681288005841 active site 681288005842 catalytic residues [active] 681288005843 metal binding site [ion binding]; metal-binding site 681288005844 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 681288005845 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 681288005846 tartrate dehydrogenase; Provisional; Region: PRK08194 681288005847 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 681288005848 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 681288005849 substrate binding site [chemical binding]; other site 681288005850 ligand binding site [chemical binding]; other site 681288005851 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 681288005852 substrate binding site [chemical binding]; other site 681288005853 threonine dehydratase; Validated; Region: PRK08639 681288005854 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 681288005855 tetramer interface [polypeptide binding]; other site 681288005856 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288005857 catalytic residue [active] 681288005858 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 681288005859 putative Ile/Val binding site [chemical binding]; other site 681288005860 hypothetical protein; Provisional; Region: PRK04351 681288005861 SprT homologues; Region: SprT; cl01182 681288005862 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 681288005863 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 681288005864 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 681288005865 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 681288005866 RNA binding site [nucleotide binding]; other site 681288005867 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 681288005868 Transposase; Region: DDE_Tnp_ISL3; pfam01610 681288005869 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 681288005870 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 681288005871 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 681288005872 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 681288005873 DNA binding residues [nucleotide binding] 681288005874 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 681288005875 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 681288005876 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 681288005877 anti sigma factor interaction site; other site 681288005878 regulatory phosphorylation site [posttranslational modification]; other site 681288005879 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 681288005880 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 681288005881 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 681288005882 PemK-like protein; Region: PemK; cl00995 681288005883 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 681288005884 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 681288005885 active site 681288005886 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 681288005887 dimer interface [polypeptide binding]; other site 681288005888 substrate binding site [chemical binding]; other site 681288005889 catalytic residues [active] 681288005890 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 681288005891 Bacterial PH domain; Region: DUF304; cl01348 681288005892 Predicted membrane protein [Function unknown]; Region: COG3428 681288005893 Bacterial PH domain; Region: DUF304; cl01348 681288005894 Bacterial PH domain; Region: DUF304; cl01348 681288005895 Bacterial PH domain; Region: DUF304; cl01348 681288005896 K+-transporting ATPase, c chain; Region: KdpC; cl00944 681288005897 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 681288005898 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 681288005899 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 681288005900 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 681288005901 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 681288005902 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 681288005903 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 681288005904 Ligand Binding Site [chemical binding]; other site 681288005905 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 681288005906 dimer interface [polypeptide binding]; other site 681288005907 phosphorylation site [posttranslational modification] 681288005908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 681288005909 ATP binding site [chemical binding]; other site 681288005910 Mg2+ binding site [ion binding]; other site 681288005911 G-X-G motif; other site 681288005912 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 681288005913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 681288005914 active site 681288005915 phosphorylation site [posttranslational modification] 681288005916 intermolecular recognition site; other site 681288005917 dimerization interface [polypeptide binding]; other site 681288005918 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 681288005919 DNA binding site [nucleotide binding] 681288005920 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 681288005921 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 681288005922 ATP binding site [chemical binding]; other site 681288005923 Mg++ binding site [ion binding]; other site 681288005924 motif III; other site 681288005925 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 681288005926 nucleotide binding region [chemical binding]; other site 681288005927 ATP-binding site [chemical binding]; other site 681288005928 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 681288005929 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 681288005930 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 681288005931 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 681288005932 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 681288005933 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 681288005934 ATP-grasp domain; Region: ATP-grasp_4; cl03087 681288005935 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 681288005936 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 681288005937 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 681288005938 putative homodimer interface [polypeptide binding]; other site 681288005939 putative homotetramer interface [polypeptide binding]; other site 681288005940 allosteric switch controlling residues; other site 681288005941 putative metal binding site [ion binding]; other site 681288005942 putative homodimer-homodimer interface [polypeptide binding]; other site 681288005943 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 681288005944 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 681288005945 putative active site [active] 681288005946 catalytic site [active] 681288005947 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 681288005948 putative active site [active] 681288005949 catalytic site [active] 681288005950 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 681288005951 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 681288005952 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 681288005953 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 681288005954 thiamine phosphate binding site [chemical binding]; other site 681288005955 active site 681288005956 pyrophosphate binding site [ion binding]; other site 681288005957 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 681288005958 substrate binding site [chemical binding]; other site 681288005959 multimerization interface [polypeptide binding]; other site 681288005960 ATP binding site [chemical binding]; other site 681288005961 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 681288005962 dimer interface [polypeptide binding]; other site 681288005963 substrate binding site [chemical binding]; other site 681288005964 ATP binding site [chemical binding]; other site 681288005965 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 681288005966 SAAV_2149 681288005967 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 681288005968 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 681288005969 dimer interface [polypeptide binding]; other site 681288005970 ssDNA binding site [nucleotide binding]; other site 681288005971 tetramer (dimer of dimers) interface [polypeptide binding]; other site 681288005972 YwpF-like protein; Region: YwpF; pfam14183 681288005973 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 681288005974 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 681288005975 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 681288005976 hinge; other site 681288005977 active site 681288005978 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 681288005979 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735 681288005980 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 681288005981 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 681288005982 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 681288005983 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 681288005984 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 681288005985 alpha subunit interaction interface [polypeptide binding]; other site 681288005986 Walker A motif; other site 681288005987 ATP binding site [chemical binding]; other site 681288005988 Walker B motif; other site 681288005989 inhibitor binding site; inhibition site 681288005990 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 681288005991 ATP synthase; Region: ATP-synt; cl00365 681288005992 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 681288005993 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 681288005994 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 681288005995 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 681288005996 beta subunit interaction interface [polypeptide binding]; other site 681288005997 Walker A motif; other site 681288005998 ATP binding site [chemical binding]; other site 681288005999 Walker B motif; other site 681288006000 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 681288006001 Plant ATP synthase F0; Region: YMF19; cl07975 681288006002 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 681288006003 Plant ATP synthase F0; Region: YMF19; cl07975 681288006004 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 681288006005 ATP synthase subunit C; Region: ATP-synt_C; cl00466 681288006006 ATP synthase A chain; Region: ATP-synt_A; cl00413 681288006007 Bacterial ATP synthase I; Region: Bac_ATP_syn_I; pfam05468 681288006008 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 681288006009 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 681288006010 active site 681288006011 homodimer interface [polypeptide binding]; other site 681288006012 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 681288006013 active site 681288006014 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 681288006015 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 681288006016 dimer interface [polypeptide binding]; other site 681288006017 active site 681288006018 glycine-pyridoxal phosphate binding site [chemical binding]; other site 681288006019 folate binding site [chemical binding]; other site 681288006020 Protein of unknown function (DUF436); Region: DUF436; cl01860 681288006021 Low molecular weight phosphatase family; Region: LMWPc; cd00115 681288006022 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 681288006023 active site 681288006024 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 681288006025 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 681288006026 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 681288006027 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 681288006028 S-adenosylmethionine binding site [chemical binding]; other site 681288006029 peptide chain release factor 1; Validated; Region: prfA; PRK00591 681288006030 RF-1 domain; Region: RF-1; cl02875 681288006031 RF-1 domain; Region: RF-1; cl02875 681288006032 thymidine kinase; Provisional; Region: PRK04296 681288006033 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 681288006034 transcription termination factor Rho; Provisional; Region: rho; PRK09376 681288006035 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 681288006036 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 681288006037 RNA binding site [nucleotide binding]; other site 681288006038 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 681288006039 multimer interface [polypeptide binding]; other site 681288006040 Walker A motif; other site 681288006041 ATP binding site [chemical binding]; other site 681288006042 Walker B motif; other site 681288006043 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 681288006044 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 681288006045 NAD binding site [chemical binding]; other site 681288006046 catalytic residues [active] 681288006047 Helix-turn-helix domains; Region: HTH; cl00088 681288006048 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 681288006049 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 681288006050 hinge; other site 681288006051 active site 681288006052 hypothetical protein; Provisional; Region: PRK08185 681288006053 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 681288006054 intersubunit interface [polypeptide binding]; other site 681288006055 active site 681288006056 zinc binding site [ion binding]; other site 681288006057 Na+ binding site [ion binding]; other site 681288006058 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 681288006059 CTP synthetase; Validated; Region: pyrG; PRK05380 681288006060 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 681288006061 Catalytic site [active] 681288006062 active site 681288006063 UTP binding site [chemical binding]; other site 681288006064 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 681288006065 active site 681288006066 putative oxyanion hole; other site 681288006067 catalytic triad [active] 681288006068 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 681288006069 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 681288006070 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 681288006071 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 681288006072 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 681288006073 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 681288006074 ATP-grasp domain; Region: ATP-grasp_4; cl03087 681288006075 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 681288006076 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 681288006077 metal binding site [ion binding]; metal-binding site 681288006078 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 681288006079 Predicted membrane protein [Function unknown]; Region: COG4270 681288006080 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 681288006081 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 681288006082 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 681288006083 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 681288006084 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 681288006085 intersubunit interface [polypeptide binding]; other site 681288006086 active site 681288006087 catalytic residue [active] 681288006088 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 681288006089 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 681288006090 Ferritin-like domain; Region: Ferritin; pfam00210 681288006091 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 681288006092 dimerization interface [polypeptide binding]; other site 681288006093 DPS ferroxidase diiron center [ion binding]; other site 681288006094 ion pore; other site 681288006095 Protein of unknown function, DUF393; Region: DUF393; cl01136 681288006096 EVE domain; Region: EVE; cl00728 681288006097 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 681288006098 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 681288006099 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 681288006100 NADH(P)-binding; Region: NAD_binding_10; pfam13460 681288006101 NAD(P) binding site [chemical binding]; other site 681288006102 putative active site [active] 681288006103 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 681288006104 dimerization interface [polypeptide binding]; other site 681288006105 putative DNA binding site [nucleotide binding]; other site 681288006106 putative Zn2+ binding site [ion binding]; other site 681288006107 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 681288006108 Cation efflux family; Region: Cation_efflux; cl00316 681288006109 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 681288006110 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 681288006111 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 681288006112 active site 681288006113 motif I; other site 681288006114 motif II; other site 681288006115 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 681288006116 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 681288006117 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288006118 Walker A/P-loop; other site 681288006119 ATP binding site [chemical binding]; other site 681288006120 Q-loop/lid; other site 681288006121 ABC transporter signature motif; other site 681288006122 Walker B; other site 681288006123 D-loop; other site 681288006124 H-loop/switch region; other site 681288006125 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 681288006126 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 681288006127 glutaminase active site [active] 681288006128 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 681288006129 dimer interface [polypeptide binding]; other site 681288006130 active site 681288006131 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 681288006132 dimer interface [polypeptide binding]; other site 681288006133 active site 681288006134 SAAV_2209 681288006135 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 681288006136 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 681288006137 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 681288006138 active site 681288006139 P-loop; other site 681288006140 phosphorylation site [posttranslational modification] 681288006141 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 681288006142 Helix-turn-helix domains; Region: HTH; cl00088 681288006143 Helix-turn-helix domains; Region: HTH; cl00088 681288006144 PRD domain; Region: PRD; cl15445 681288006145 PRD domain; Region: PRD; cl15445 681288006146 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 681288006147 active site 681288006148 P-loop; other site 681288006149 phosphorylation site [posttranslational modification] 681288006150 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 681288006151 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 681288006152 active site 681288006153 phosphorylation site [posttranslational modification] 681288006154 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 681288006155 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 681288006156 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 681288006157 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 681288006158 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288006159 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288006160 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288006161 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288006162 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288006163 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288006164 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288006165 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288006166 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288006167 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 681288006168 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 681288006169 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 681288006170 active site 681288006171 substrate binding site [chemical binding]; other site 681288006172 metal binding site [ion binding]; metal-binding site 681288006173 YbbR-like protein; Region: YbbR; pfam07949 681288006174 YbbR-like protein; Region: YbbR; pfam07949 681288006175 TIGR00159 family protein; Region: TIGR00159 681288006176 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 681288006177 Arginase family; Region: Arginase; cl00306 681288006178 RecA-family ATPase [DNA replication, recombination, and repair]; Region: RepA; COG3598 681288006179 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 681288006180 Walker A motif; other site 681288006181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288006182 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 681288006183 putative substrate translocation pore; other site 681288006184 Major Facilitator Superfamily; Region: MFS_1; pfam07690 681288006185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 681288006186 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288006187 Haemolysin-III related; Region: HlyIII; cl03831 681288006188 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 681288006189 substrate binding site; other site 681288006190 dimerization interface; other site 681288006191 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 681288006192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 681288006193 Nucleoside recognition; Region: Gate; cl00486 681288006194 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 681288006195 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 681288006196 ABC-ATPase subunit interface; other site 681288006197 dimer interface [polypeptide binding]; other site 681288006198 putative PBP binding regions; other site 681288006199 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 681288006200 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 681288006201 ABC-ATPase subunit interface; other site 681288006202 dimer interface [polypeptide binding]; other site 681288006203 putative PBP binding regions; other site 681288006204 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 681288006205 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 681288006206 siderophore binding site; other site 681288006207 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 681288006208 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 681288006209 dimer interface [polypeptide binding]; other site 681288006210 active site 681288006211 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 681288006212 substrate binding site [chemical binding]; other site 681288006213 catalytic residue [active] 681288006214 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 681288006215 IucA / IucC family; Region: IucA_IucC; pfam04183 681288006216 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 681288006217 H+ Antiporter protein; Region: 2A0121; TIGR00900 681288006218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288006219 putative substrate translocation pore; other site 681288006220 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 681288006221 IucA / IucC family; Region: IucA_IucC; pfam04183 681288006222 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 681288006223 Asp23 family; Region: Asp23; cl00574 681288006224 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 681288006225 BCCT family transporter; Region: BCCT; cl00569 681288006226 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 681288006227 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 681288006228 putative NAD(P) binding site [chemical binding]; other site 681288006229 dimer interface [polypeptide binding]; other site 681288006230 leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase; Region: B4_12hDH; TIGR02825 681288006231 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288006232 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 681288006233 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 681288006234 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 681288006235 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 681288006236 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 681288006237 active site 681288006238 P-loop; other site 681288006239 phosphorylation site [posttranslational modification] 681288006240 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 681288006241 methionine cluster; other site 681288006242 active site 681288006243 phosphorylation site [posttranslational modification] 681288006244 metal binding site [ion binding]; metal-binding site 681288006245 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 681288006246 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 681288006247 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 681288006248 putative substrate binding site [chemical binding]; other site 681288006249 putative ATP binding site [chemical binding]; other site 681288006250 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 681288006251 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 681288006252 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 681288006253 Helix-turn-helix domains; Region: HTH; cl00088 681288006254 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 681288006255 NAD-dependent deacetylase; Provisional; Region: PRK00481 681288006256 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 681288006257 NAD+ binding site [chemical binding]; other site 681288006258 substrate binding site [chemical binding]; other site 681288006259 putative Zn binding site [ion binding]; other site 681288006260 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 681288006261 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 681288006262 active site 681288006263 catalytic tetrad [active] 681288006264 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 681288006265 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 681288006266 DNA binding residues [nucleotide binding] 681288006267 putative dimer interface [polypeptide binding]; other site 681288006268 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 681288006269 substrate binding site [chemical binding]; other site 681288006270 catalytic residues [active] 681288006271 Peptidase family M23; Region: Peptidase_M23; pfam01551 681288006272 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 681288006273 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 681288006274 active site 681288006275 motif I; other site 681288006276 motif II; other site 681288006277 MAP domain; Region: MAP; pfam03642 681288006278 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 681288006279 acetolactate synthase; Reviewed; Region: PRK08617 681288006280 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 681288006281 PYR/PP interface [polypeptide binding]; other site 681288006282 dimer interface [polypeptide binding]; other site 681288006283 TPP binding site [chemical binding]; other site 681288006284 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 681288006285 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 681288006286 TPP-binding site [chemical binding]; other site 681288006287 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 681288006288 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 681288006289 putative active site [active] 681288006290 putative NTP binding site [chemical binding]; other site 681288006291 putative nucleic acid binding site [nucleotide binding]; other site 681288006292 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288006293 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 681288006294 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 681288006295 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 681288006296 23S rRNA interface [nucleotide binding]; other site 681288006297 L3 interface [polypeptide binding]; other site 681288006298 SAAV_2280 681288006299 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 681288006300 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 681288006301 dimerization interface 3.5A [polypeptide binding]; other site 681288006302 active site 681288006303 Cobalt transport protein; Region: CbiQ; cl00463 681288006304 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646 681288006305 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 681288006306 Walker A/P-loop; other site 681288006307 ATP binding site [chemical binding]; other site 681288006308 Q-loop/lid; other site 681288006309 ABC transporter signature motif; other site 681288006310 Walker B; other site 681288006311 D-loop; other site 681288006312 H-loop/switch region; other site 681288006313 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648 681288006314 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 681288006315 Walker A/P-loop; other site 681288006316 ATP binding site [chemical binding]; other site 681288006317 Q-loop/lid; other site 681288006318 ABC transporter signature motif; other site 681288006319 Walker B; other site 681288006320 D-loop; other site 681288006321 H-loop/switch region; other site 681288006322 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 681288006323 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 681288006324 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 681288006325 alphaNTD homodimer interface [polypeptide binding]; other site 681288006326 alphaNTD - beta interaction site [polypeptide binding]; other site 681288006327 alphaNTD - beta' interaction site [polypeptide binding]; other site 681288006328 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 681288006329 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 681288006330 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 681288006331 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 681288006332 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 681288006333 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 681288006334 rRNA binding site [nucleotide binding]; other site 681288006335 predicted 30S ribosome binding site; other site 681288006336 adenylate kinase; Reviewed; Region: adk; PRK00279 681288006337 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 681288006338 AMP-binding site [chemical binding]; other site 681288006339 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 681288006340 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 681288006341 SecY translocase; Region: SecY; pfam00344 681288006342 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 681288006343 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 681288006344 23S rRNA binding site [nucleotide binding]; other site 681288006345 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 681288006346 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 681288006347 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 681288006348 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 681288006349 5S rRNA interface [nucleotide binding]; other site 681288006350 L27 interface [polypeptide binding]; other site 681288006351 23S rRNA interface [nucleotide binding]; other site 681288006352 L5 interface [polypeptide binding]; other site 681288006353 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 681288006354 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 681288006355 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 681288006356 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 681288006357 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 681288006358 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 681288006359 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 681288006360 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 681288006361 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 681288006362 KOW motif; Region: KOW; cl00354 681288006363 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 681288006364 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 681288006365 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 681288006366 23S rRNA interface [nucleotide binding]; other site 681288006367 putative translocon interaction site; other site 681288006368 signal recognition particle (SRP54) interaction site; other site 681288006369 L23 interface [polypeptide binding]; other site 681288006370 trigger factor interaction site; other site 681288006371 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 681288006372 23S rRNA interface [nucleotide binding]; other site 681288006373 5S rRNA interface [nucleotide binding]; other site 681288006374 putative antibiotic binding site [chemical binding]; other site 681288006375 L25 interface [polypeptide binding]; other site 681288006376 L27 interface [polypeptide binding]; other site 681288006377 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 681288006378 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 681288006379 G-X-X-G motif; other site 681288006380 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 681288006381 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 681288006382 putative translocon binding site; other site 681288006383 protein-rRNA interface [nucleotide binding]; other site 681288006384 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 681288006385 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 681288006386 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 681288006387 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 681288006388 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 681288006389 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 681288006390 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 681288006391 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 681288006392 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 681288006393 DNA topoisomerase III; Provisional; Region: PRK07726 681288006394 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 681288006395 active site 681288006396 putative interdomain interaction site [polypeptide binding]; other site 681288006397 putative metal-binding site [ion binding]; other site 681288006398 putative nucleotide binding site [chemical binding]; other site 681288006399 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 681288006400 domain I; other site 681288006401 DNA binding groove [nucleotide binding] 681288006402 phosphate binding site [ion binding]; other site 681288006403 domain II; other site 681288006404 domain III; other site 681288006405 nucleotide binding site [chemical binding]; other site 681288006406 catalytic site [active] 681288006407 domain IV; other site 681288006408 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 681288006409 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 681288006410 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 681288006411 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 681288006412 Membrane transport protein; Region: Mem_trans; cl09117 681288006413 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 681288006414 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 681288006415 Helix-turn-helix domains; Region: HTH; cl00088 681288006416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288006417 Major Facilitator Superfamily; Region: MFS_1; pfam07690 681288006418 putative substrate translocation pore; other site 681288006419 Helix-turn-helix domains; Region: HTH; cl00088 681288006420 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 681288006421 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 681288006422 FeS/SAM binding site; other site 681288006423 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 681288006424 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 681288006425 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 681288006426 GTP binding site; other site 681288006427 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 681288006428 MoaE interaction surface [polypeptide binding]; other site 681288006429 MoeB interaction surface [polypeptide binding]; other site 681288006430 thiocarboxylated glycine; other site 681288006431 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 681288006432 MoaE homodimer interface [polypeptide binding]; other site 681288006433 MoaD interaction [polypeptide binding]; other site 681288006434 active site residues [active] 681288006435 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288006436 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 681288006437 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 681288006438 dimer interface [polypeptide binding]; other site 681288006439 putative functional site; other site 681288006440 putative MPT binding site; other site 681288006441 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 681288006442 trimer interface [polypeptide binding]; other site 681288006443 dimer interface [polypeptide binding]; other site 681288006444 putative active site [active] 681288006445 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 681288006446 MPT binding site; other site 681288006447 trimer interface [polypeptide binding]; other site 681288006448 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 681288006449 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 681288006450 ATP binding site [chemical binding]; other site 681288006451 substrate interface [chemical binding]; other site 681288006452 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288006453 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 681288006454 Walker A/P-loop; other site 681288006455 ATP binding site [chemical binding]; other site 681288006456 Q-loop/lid; other site 681288006457 ABC transporter signature motif; other site 681288006458 Walker B; other site 681288006459 D-loop; other site 681288006460 H-loop/switch region; other site 681288006461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288006462 dimer interface [polypeptide binding]; other site 681288006463 conserved gate region; other site 681288006464 putative PBP binding loops; other site 681288006465 ABC-ATPase subunit interface; other site 681288006466 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 681288006467 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 681288006468 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 681288006469 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 681288006470 Coenzyme A binding pocket [chemical binding]; other site 681288006471 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 681288006472 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 681288006473 active site 681288006474 dimerization interface [polypeptide binding]; other site 681288006475 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 681288006476 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 681288006477 intersubunit interface [polypeptide binding]; other site 681288006478 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 681288006479 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 681288006480 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 681288006481 Urea transporter; Region: UT; cl01829 681288006482 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 681288006483 alpha-gamma subunit interface [polypeptide binding]; other site 681288006484 beta-gamma subunit interface [polypeptide binding]; other site 681288006485 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 681288006486 gamma-beta subunit interface [polypeptide binding]; other site 681288006487 alpha-beta subunit interface [polypeptide binding]; other site 681288006488 urease subunit alpha; Reviewed; Region: ureC; PRK13207 681288006489 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 681288006490 subunit interactions [polypeptide binding]; other site 681288006491 active site 681288006492 flap region; other site 681288006493 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 681288006494 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 681288006495 dimer interface [polypeptide binding]; other site 681288006496 catalytic residues [active] 681288006497 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 681288006498 UreF; Region: UreF; pfam01730 681288006499 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288006500 UreD urease accessory protein; Region: UreD; cl00530 681288006501 Helix-turn-helix domains; Region: HTH; cl00088 681288006502 Helix-turn-helix domains; Region: HTH; cl00088 681288006503 Helix-turn-helix domains; Region: HTH; cl00088 681288006504 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 681288006505 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 681288006506 NlpC/P60 family; Region: NLPC_P60; cl11438 681288006507 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 681288006508 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 681288006509 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288006510 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 681288006511 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296; cl15800 681288006512 NlpC/P60 family; Region: NLPC_P60; cl11438 681288006513 glyoxylate reductase; Reviewed; Region: PRK13243 681288006514 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288006515 hypothetical protein; Provisional; Region: PRK06753 681288006516 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288006517 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 681288006518 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 681288006519 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 681288006520 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 681288006521 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 681288006522 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 681288006523 4Fe-4S binding domain; Region: Fer4; cl02805 681288006524 4Fe-4S binding domain; Region: Fer4; cl02805 681288006525 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 681288006526 [4Fe-4S] binding site [ion binding]; other site 681288006527 molybdopterin cofactor binding site; other site 681288006528 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 681288006529 molybdopterin cofactor binding site; other site 681288006530 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 681288006531 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 681288006532 active site 681288006533 Predicted transcriptional regulator [Transcription]; Region: COG2378 681288006534 Helix-turn-helix domains; Region: HTH; cl00088 681288006535 CAAX protease self-immunity; Region: Abi; cl00558 681288006536 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 681288006537 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 681288006538 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 681288006539 putative active site [active] 681288006540 putative transport protein YifK; Provisional; Region: PRK10746 681288006541 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 681288006542 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 681288006543 active site 681288006544 motif I; other site 681288006545 motif II; other site 681288006546 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 681288006547 Membrane transport protein; Region: Mem_trans; cl09117 681288006548 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 681288006549 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 681288006550 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 681288006551 active site turn [active] 681288006552 phosphorylation site [posttranslational modification] 681288006553 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 681288006554 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 681288006555 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 681288006556 putative active site [active] 681288006557 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 681288006558 putative hydrophobic ligand binding site [chemical binding]; other site 681288006559 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 681288006560 SAAV_2390 681288006561 oxidoreductase; Provisional; Region: PRK07985 681288006562 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288006563 NAD(P) binding site [chemical binding]; other site 681288006564 active site 681288006565 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 681288006566 amidohydrolase; Region: amidohydrolases; TIGR01891 681288006567 metal binding site [ion binding]; metal-binding site 681288006568 dimer interface [polypeptide binding]; other site 681288006569 imidazolonepropionase; Validated; Region: PRK09356 681288006570 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 681288006571 active site 681288006572 urocanate hydratase; Provisional; Region: PRK05414 681288006573 Transcriptional regulator [Transcription]; Region: LysR; COG0583 681288006574 Helix-turn-helix domains; Region: HTH; cl00088 681288006575 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 681288006576 dimerization interface [polypeptide binding]; other site 681288006577 FosB, a fosfomycin resistance protein, catalyzes the Mg(II) dependent addition of L-cysteine to the epoxide ring of fosfomycin; Region: FosB; cd08363 681288006578 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 681288006579 putative active site [active] 681288006580 putative Mg binding site [ion binding]; other site 681288006581 Arginase family; Region: Arginase; cl00306 681288006582 CAAX protease self-immunity; Region: Abi; cl00558 681288006583 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 681288006584 tetramer (dimer of dimers) interface [polypeptide binding]; other site 681288006585 active site 681288006586 dimer interface [polypeptide binding]; other site 681288006587 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 681288006588 MOSC domain; Region: MOSC; pfam03473 681288006589 3-alpha domain; Region: 3-alpha; pfam03475 681288006590 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 681288006591 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 681288006592 active site 681288006593 catalytic residues [active] 681288006594 Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 681288006595 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 681288006596 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 681288006597 This subfamily is involved in drug resistance, nodulation, lipid transport, and bacteriocin and lantibiotic immunity. In eubacteria and archaea, the typical organization consists of one ABC and one or two IMs. Eukaryote systems of the ABCA subfamily...; Region: ABC_putative_ATPase; cd03269 681288006598 Walker A/P-loop; other site 681288006599 ATP binding site [chemical binding]; other site 681288006600 Q-loop/lid; other site 681288006601 ABC transporter signature motif; other site 681288006602 Walker B; other site 681288006603 D-loop; other site 681288006604 H-loop/switch region; other site 681288006605 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 681288006606 Protein of unknown function (DUF805); Region: DUF805; cl01224 681288006607 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 681288006608 active site 681288006609 DNA binding site [nucleotide binding] 681288006610 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 681288006611 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 681288006612 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 681288006613 homotetramer interface [polypeptide binding]; other site 681288006614 FMN binding site [chemical binding]; other site 681288006615 homodimer contacts [polypeptide binding]; other site 681288006616 putative active site [active] 681288006617 putative substrate binding site [chemical binding]; other site 681288006618 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 681288006619 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 681288006620 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 681288006621 active site 681288006622 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 681288006623 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 681288006624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288006625 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 681288006626 putative substrate translocation pore; other site 681288006627 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 681288006628 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 681288006629 E3 interaction surface; other site 681288006630 lipoyl attachment site [posttranslational modification]; other site 681288006631 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 681288006632 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 681288006633 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288006634 putative substrate translocation pore; other site 681288006635 Predicted membrane protein [Function unknown]; Region: COG4640 681288006636 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 681288006637 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 681288006638 Helix-turn-helix domains; Region: HTH; cl00088 681288006639 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 681288006640 putative active site [active] 681288006641 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 681288006642 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 681288006643 Walker A/P-loop; other site 681288006644 ATP binding site [chemical binding]; other site 681288006645 Q-loop/lid; other site 681288006646 ABC transporter signature motif; other site 681288006647 Walker B; other site 681288006648 D-loop; other site 681288006649 H-loop/switch region; other site 681288006650 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 681288006651 FtsX-like permease family; Region: FtsX; cl15850 681288006652 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 681288006653 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 681288006654 active site 681288006655 phosphorylation site [posttranslational modification] 681288006656 intermolecular recognition site; other site 681288006657 dimerization interface [polypeptide binding]; other site 681288006658 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 681288006659 DNA binding site [nucleotide binding] 681288006660 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 681288006661 dimerization interface [polypeptide binding]; other site 681288006662 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 681288006663 dimer interface [polypeptide binding]; other site 681288006664 phosphorylation site [posttranslational modification] 681288006665 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 681288006666 ATP binding site [chemical binding]; other site 681288006667 Mg2+ binding site [ion binding]; other site 681288006668 G-X-G motif; other site 681288006669 LytTr DNA-binding domain; Region: LytTR; cl04498 681288006670 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 681288006671 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288006672 Predicted dehydrogenase [General function prediction only]; Region: COG0579 681288006673 L-lactate permease; Region: Lactate_perm; cl00701 681288006674 glycolate transporter; Provisional; Region: PRK09695 681288006675 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 681288006676 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 681288006677 Coenzyme A binding pocket [chemical binding]; other site 681288006678 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 681288006679 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288006680 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 681288006681 NAD(P) binding site [chemical binding]; other site 681288006682 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 681288006683 Coenzyme A binding pocket [chemical binding]; other site 681288006684 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 681288006685 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288006686 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 681288006687 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 681288006688 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 681288006689 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 681288006690 ABC-2 type transporter; Region: ABC2_membrane; cl11417 681288006691 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 681288006692 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 681288006693 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 681288006694 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 681288006695 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 681288006696 active site turn [active] 681288006697 phosphorylation site [posttranslational modification] 681288006698 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 681288006699 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 681288006700 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 681288006701 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 681288006702 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 681288006703 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 681288006704 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 681288006705 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 681288006706 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 681288006707 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 681288006708 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 681288006709 Helix-turn-helix domains; Region: HTH; cl00088 681288006710 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 681288006711 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 681288006712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288006713 putative substrate translocation pore; other site 681288006714 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 681288006715 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 681288006716 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 681288006717 DNA binding residues [nucleotide binding] 681288006718 dimer interface [polypeptide binding]; other site 681288006719 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 681288006720 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 681288006721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 681288006722 active site 681288006723 phosphorylation site [posttranslational modification] 681288006724 intermolecular recognition site; other site 681288006725 dimerization interface [polypeptide binding]; other site 681288006726 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 681288006727 DNA binding residues [nucleotide binding] 681288006728 dimerization interface [polypeptide binding]; other site 681288006729 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 681288006730 Histidine kinase; Region: HisKA_3; pfam07730 681288006731 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 681288006732 ATP binding site [chemical binding]; other site 681288006733 Mg2+ binding site [ion binding]; other site 681288006734 G-X-G motif; other site 681288006735 GAF domain; Region: GAF; cl15785 681288006736 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 681288006737 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 681288006738 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 681288006739 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 681288006740 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 681288006741 [4Fe-4S] binding site [ion binding]; other site 681288006742 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 681288006743 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 681288006744 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 681288006745 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 681288006746 molybdopterin cofactor binding site; other site 681288006747 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 681288006748 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 681288006749 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 681288006750 [2Fe-2S] cluster binding site [ion binding]; other site 681288006751 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 681288006752 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 681288006753 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 681288006754 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 681288006755 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 681288006756 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 681288006757 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 681288006758 putative active site [active] 681288006759 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 681288006760 active site 681288006761 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 681288006762 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 681288006763 Coenzyme A binding pocket [chemical binding]; other site 681288006764 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 681288006765 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 681288006766 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 681288006767 putative hydrophobic ligand binding site [chemical binding]; other site 681288006768 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 681288006769 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 681288006770 intersubunit interface [polypeptide binding]; other site 681288006771 YodA lipocalin-like domain; Region: YodA; cl01365 681288006772 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 681288006773 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 681288006774 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 681288006775 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 681288006776 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 681288006777 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 681288006778 Walker A/P-loop; other site 681288006779 ATP binding site [chemical binding]; other site 681288006780 Q-loop/lid; other site 681288006781 ABC transporter signature motif; other site 681288006782 Walker B; other site 681288006783 D-loop; other site 681288006784 H-loop/switch region; other site 681288006785 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 681288006786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288006787 dimer interface [polypeptide binding]; other site 681288006788 conserved gate region; other site 681288006789 putative PBP binding loops; other site 681288006790 ABC-ATPase subunit interface; other site 681288006791 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 681288006792 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 681288006793 substrate binding pocket [chemical binding]; other site 681288006794 membrane-bound complex binding site; other site 681288006795 hinge residues; other site 681288006796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288006797 Major Facilitator Superfamily; Region: MFS_1; pfam07690 681288006798 putative substrate translocation pore; other site 681288006799 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288006800 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 681288006801 catalytic core [active] 681288006802 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 681288006803 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 681288006804 Cation efflux family; Region: Cation_efflux; cl00316 681288006805 B domain; Region: B; pfam02216 681288006806 B domain; Region: B; pfam02216 681288006807 C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621 681288006808 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 681288006809 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 681288006810 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 681288006811 6-carboxyhexanoate--CoA ligase; Region: BioW; cl00625 681288006812 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 681288006813 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 681288006814 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 681288006815 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 681288006816 catalytic residue [active] 681288006817 biotin synthase; Validated; Region: PRK06256 681288006818 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 681288006819 FeS/SAM binding site; other site 681288006820 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 681288006821 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 681288006822 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 681288006823 inhibitor-cofactor binding pocket; inhibition site 681288006824 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288006825 catalytic residue [active] 681288006826 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 681288006827 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288006828 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288006829 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 681288006830 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 681288006831 Walker A/P-loop; other site 681288006832 ATP binding site [chemical binding]; other site 681288006833 Q-loop/lid; other site 681288006834 ABC transporter signature motif; other site 681288006835 Walker B; other site 681288006836 D-loop; other site 681288006837 H-loop/switch region; other site 681288006838 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 681288006839 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 681288006840 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288006841 Walker A/P-loop; other site 681288006842 ATP binding site [chemical binding]; other site 681288006843 Q-loop/lid; other site 681288006844 ABC transporter signature motif; other site 681288006845 Walker B; other site 681288006846 D-loop; other site 681288006847 H-loop/switch region; other site 681288006848 GtrA-like protein; Region: GtrA; cl00971 681288006849 Glycerate kinase family; Region: Gly_kinase; cl00841 681288006850 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 681288006851 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 681288006852 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288006853 putative substrate translocation pore; other site 681288006854 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 681288006855 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 681288006856 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 681288006857 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 681288006858 active site 681288006859 metal binding site [ion binding]; metal-binding site 681288006860 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 681288006861 Spore germination protein; Region: Spore_permease; cl15802 681288006862 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 681288006863 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 681288006864 Amino acid permease; Region: AA_permease_2; pfam13520 681288006865 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 681288006866 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 681288006867 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288006868 NAD(P) binding site [chemical binding]; other site 681288006869 active site 681288006870 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 681288006871 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288006872 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 681288006873 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288006874 putative substrate translocation pore; other site 681288006875 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288006876 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 681288006877 NMT1-like family; Region: NMT1_2; cl15260 681288006878 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 681288006879 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 681288006880 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 681288006881 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 681288006882 Walker A/P-loop; other site 681288006883 ATP binding site [chemical binding]; other site 681288006884 Q-loop/lid; other site 681288006885 ABC transporter signature motif; other site 681288006886 Walker B; other site 681288006887 D-loop; other site 681288006888 H-loop/switch region; other site 681288006889 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 681288006890 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 681288006891 Protein of unknown function (DUF419); Region: DUF419; cl15265 681288006892 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 681288006893 amino acid transporter; Region: 2A0306; TIGR00909 681288006894 Spore germination protein; Region: Spore_permease; cl15802 681288006895 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 681288006896 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 681288006897 substrate binding pocket [chemical binding]; other site 681288006898 catalytic triad [active] 681288006899 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 681288006900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288006901 putative substrate translocation pore; other site 681288006902 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 681288006903 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 681288006904 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 681288006905 Walker A/P-loop; other site 681288006906 ATP binding site [chemical binding]; other site 681288006907 Q-loop/lid; other site 681288006908 ABC transporter signature motif; other site 681288006909 Walker B; other site 681288006910 D-loop; other site 681288006911 H-loop/switch region; other site 681288006912 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 681288006913 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 681288006914 oligomer interface [polypeptide binding]; other site 681288006915 active site 681288006916 metal binding site [ion binding]; metal-binding site 681288006917 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 681288006918 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 681288006919 Protein of unknown function (DUF1307); Region: DUF1307; cl01981 681288006920 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 681288006921 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 681288006922 active site 681288006923 FMN binding site [chemical binding]; other site 681288006924 substrate binding site [chemical binding]; other site 681288006925 3Fe-4S cluster binding site [ion binding]; other site 681288006926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288006927 Major Facilitator Superfamily; Region: MFS_1; pfam07690 681288006928 putative substrate translocation pore; other site 681288006929 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 681288006930 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 681288006931 Walker A/P-loop; other site 681288006932 ATP binding site [chemical binding]; other site 681288006933 Q-loop/lid; other site 681288006934 ABC transporter signature motif; other site 681288006935 Walker B; other site 681288006936 D-loop; other site 681288006937 H-loop/switch region; other site 681288006938 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 681288006939 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 681288006940 Walker A/P-loop; other site 681288006941 ATP binding site [chemical binding]; other site 681288006942 Q-loop/lid; other site 681288006943 ABC transporter signature motif; other site 681288006944 Walker B; other site 681288006945 D-loop; other site 681288006946 H-loop/switch region; other site 681288006947 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 681288006948 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 681288006949 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288006950 dimer interface [polypeptide binding]; other site 681288006951 conserved gate region; other site 681288006952 ABC-ATPase subunit interface; other site 681288006953 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 681288006954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 681288006955 dimer interface [polypeptide binding]; other site 681288006956 conserved gate region; other site 681288006957 putative PBP binding loops; other site 681288006958 ABC-ATPase subunit interface; other site 681288006959 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 681288006960 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 681288006961 substrate binding site [chemical binding]; other site 681288006962 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 681288006963 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288006964 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 681288006965 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 681288006966 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 681288006967 short chain dehydrogenase; Validated; Region: PRK08589 681288006968 classical (c) SDRs; Region: SDR_c; cd05233 681288006969 NAD(P) binding site [chemical binding]; other site 681288006970 active site 681288006971 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 681288006972 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 681288006973 Uncharacterized conserved protein [Function unknown]; Region: COG2128 681288006974 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 681288006975 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 681288006976 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 681288006977 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 681288006978 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 681288006979 classical (c) SDRs; Region: SDR_c; cd05233 681288006980 NAD(P) binding site [chemical binding]; other site 681288006981 active site 681288006982 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 681288006983 Protein of unknown function, DUF576; Region: DUF576; cl04553 681288006984 Protein of unknown function, DUF576; Region: DUF576; cl04553 681288006985 Protein of unknown function, DUF576; Region: DUF576; cl04553 681288006986 Protein of unknown function, DUF576; Region: DUF576; cl04553 681288006987 Protein of unknown function, DUF576; Region: DUF576; cl04553 681288006988 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 681288006989 PLD-like domain; Region: PLDc_2; pfam13091 681288006990 putative homodimer interface [polypeptide binding]; other site 681288006991 putative active site [active] 681288006992 catalytic site [active] 681288006993 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 681288006994 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 681288006995 ATP binding site [chemical binding]; other site 681288006996 putative Mg++ binding site [ion binding]; other site 681288006997 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 681288006998 nucleotide binding region [chemical binding]; other site 681288006999 ATP-binding site [chemical binding]; other site 681288007000 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 681288007001 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 681288007002 active site 681288007003 8-oxo-dGMP binding site [chemical binding]; other site 681288007004 nudix motif; other site 681288007005 metal binding site [ion binding]; metal-binding site 681288007006 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 681288007007 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 681288007008 active site 681288007009 substrate binding site [chemical binding]; other site 681288007010 metal binding site [ion binding]; metal-binding site 681288007011 H+ Antiporter protein; Region: 2A0121; TIGR00900 681288007012 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 681288007013 legume lectins; Region: lectin_L-type; cl14058 681288007014 homotetramer interaction site [polypeptide binding]; other site 681288007015 carbohydrate binding site [chemical binding]; other site 681288007016 metal binding site [ion binding]; metal-binding site 681288007017 G5 domain; Region: G5; pfam07501 681288007018 G5 domain; Region: G5; pfam07501 681288007019 G5 domain; Region: G5; pfam07501 681288007020 G5 domain; Region: G5; pfam07501 681288007021 pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102 681288007022 Helix-turn-helix domains; Region: HTH; cl00088 681288007023 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 681288007024 Helix-turn-helix domains; Region: HTH; cl00088 681288007025 Helix-turn-helix domains; Region: HTH; cl00088 681288007026 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 681288007027 tetramer interface; other site 681288007028 active site 681288007029 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 681288007030 Gram positive anchor; Region: Gram_pos_anchor; cl15427 681288007031 ribonuclease E; Reviewed; Region: rne; PRK10811 681288007032 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 681288007033 Gram positive anchor; Region: Gram_pos_anchor; cl15427 681288007034 GntP family permease; Region: GntP_permease; pfam02447 681288007035 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 681288007036 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 681288007037 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 681288007038 N- and C-terminal domain interface [polypeptide binding]; other site 681288007039 putative active site [active] 681288007040 catalytic site [active] 681288007041 metal binding site [ion binding]; metal-binding site 681288007042 carbohydrate binding site [chemical binding]; other site 681288007043 ATP binding site [chemical binding]; other site 681288007044 Transcriptional regulators [Transcription]; Region: GntR; COG1802 681288007045 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 681288007046 DNA-binding site [nucleotide binding]; DNA binding site 681288007047 FCD domain; Region: FCD; cl11656 681288007048 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 681288007049 DNA binding residues [nucleotide binding] 681288007050 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 681288007051 synthetase active site [active] 681288007052 NTP binding site [chemical binding]; other site 681288007053 metal binding site [ion binding]; metal-binding site 681288007054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 681288007055 Predicted membrane protein [Function unknown]; Region: COG1289 681288007056 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 681288007057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288007058 D-galactonate transporter; Region: 2A0114; TIGR00893 681288007059 putative substrate translocation pore; other site 681288007060 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 681288007061 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 681288007062 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288007063 Walker A/P-loop; other site 681288007064 ATP binding site [chemical binding]; other site 681288007065 Q-loop/lid; other site 681288007066 ABC transporter signature motif; other site 681288007067 Walker B; other site 681288007068 D-loop; other site 681288007069 H-loop/switch region; other site 681288007070 ABC-2 type transporter; Region: ABC2_membrane; cl11417 681288007071 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 681288007072 Uncharacterized membrane protein [Function unknown]; Region: COG3949 681288007073 Predicted esterase [General function prediction only]; Region: COG0400 681288007074 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 681288007075 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 681288007076 Zn binding site [ion binding]; other site 681288007077 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 681288007078 Zn binding site [ion binding]; other site 681288007079 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 681288007080 Helix-turn-helix domains; Region: HTH; cl00088 681288007081 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 681288007082 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 681288007083 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 681288007084 putative metal binding site [ion binding]; other site 681288007085 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 681288007086 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 681288007087 dimer interface [polypeptide binding]; other site 681288007088 FMN binding site [chemical binding]; other site 681288007089 D-lactate dehydrogenase; Provisional; Region: PRK12480 681288007090 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288007091 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 681288007092 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 681288007093 active site 681288007094 motif I; other site 681288007095 motif II; other site 681288007096 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288007097 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 681288007098 Walker A/P-loop; other site 681288007099 ATP binding site [chemical binding]; other site 681288007100 Q-loop/lid; other site 681288007101 ABC transporter signature motif; other site 681288007102 Walker B; other site 681288007103 D-loop; other site 681288007104 H-loop/switch region; other site 681288007105 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 681288007106 active site 681288007107 catalytic site [active] 681288007108 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 681288007109 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 681288007110 Coenzyme A binding pocket [chemical binding]; other site 681288007111 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 681288007112 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 681288007113 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 681288007114 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 681288007115 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 681288007116 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 681288007117 EamA-like transporter family; Region: EamA; cl01037 681288007118 EamA-like transporter family; Region: EamA; cl01037 681288007119 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 681288007120 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 681288007121 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 681288007122 catalytic residues [active] 681288007123 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 681288007124 active site 681288007125 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 681288007126 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 681288007127 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 681288007128 active site turn [active] 681288007129 phosphorylation site [posttranslational modification] 681288007130 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 681288007131 HPr interaction site; other site 681288007132 glycerol kinase (GK) interaction site [polypeptide binding]; other site 681288007133 active site 681288007134 phosphorylation site [posttranslational modification] 681288007135 pyruvate oxidase; Provisional; Region: PRK08611 681288007136 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 681288007137 PYR/PP interface [polypeptide binding]; other site 681288007138 tetramer interface [polypeptide binding]; other site 681288007139 dimer interface [polypeptide binding]; other site 681288007140 TPP binding site [chemical binding]; other site 681288007141 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 681288007142 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 681288007143 TPP-binding site [chemical binding]; other site 681288007144 LrgB-like family; Region: LrgB; cl00596 681288007145 LrgA family; Region: LrgA; cl00608 681288007146 Transcriptional regulator [Transcription]; Region: LysR; COG0583 681288007147 Helix-turn-helix domains; Region: HTH; cl00088 681288007148 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 681288007149 putative dimerization interface [polypeptide binding]; other site 681288007150 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 681288007151 NlpC/P60 family; Region: NLPC_P60; cl11438 681288007152 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 681288007153 homodimer interface [polypeptide binding]; other site 681288007154 catalytic residues [active] 681288007155 NAD binding site [chemical binding]; other site 681288007156 substrate binding pocket [chemical binding]; other site 681288007157 flexible flap; other site 681288007158 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...; Region: init_cond_enzymes; cd00827 681288007159 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 681288007160 dimer interface [polypeptide binding]; other site 681288007161 active site 681288007162 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 681288007163 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 681288007164 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 681288007165 DNA binding site [nucleotide binding] 681288007166 active site 681288007167 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 681288007168 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 681288007169 Walker A motif; other site 681288007170 ATP binding site [chemical binding]; other site 681288007171 Walker B motif; other site 681288007172 arginine finger; other site 681288007173 UvrB/uvrC motif; Region: UVR; pfam02151 681288007174 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 681288007175 Walker A motif; other site 681288007176 ATP binding site [chemical binding]; other site 681288007177 Walker B motif; other site 681288007178 arginine finger; other site 681288007179 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 681288007180 Virus attachment protein p12 family; Region: P12; pfam12669 681288007181 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 681288007182 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 681288007183 G1 box; other site 681288007184 GTP/Mg2+ binding site [chemical binding]; other site 681288007185 Switch I region; other site 681288007186 G2 box; other site 681288007187 G3 box; other site 681288007188 Switch II region; other site 681288007189 G4 box; other site 681288007190 G5 box; other site 681288007191 Nucleoside recognition; Region: Gate; cl00486 681288007192 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 681288007193 Nucleoside recognition; Region: Gate; cl00486 681288007194 FeoA domain; Region: FeoA; cl00838 681288007195 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 681288007196 Ammonia monooxygenase; Region: AMO; cl03602 681288007197 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 681288007198 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 681288007199 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 681288007200 Glutamate binding site [chemical binding]; other site 681288007201 homodimer interface [polypeptide binding]; other site 681288007202 NAD binding site [chemical binding]; other site 681288007203 catalytic residues [active] 681288007204 maltose O-acetyltransferase; Provisional; Region: PRK10092 681288007205 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 681288007206 active site 681288007207 substrate binding site [chemical binding]; other site 681288007208 trimer interface [polypeptide binding]; other site 681288007209 CoA binding site [chemical binding]; other site 681288007210 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 681288007211 metal-binding site [ion binding] 681288007212 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 681288007213 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 681288007214 metal-binding site [ion binding] 681288007215 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 681288007216 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 681288007217 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 681288007218 metal-binding site [ion binding] 681288007219 D-lactate dehydrogenase; Validated; Region: PRK08605 681288007220 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288007221 transaminase; Reviewed; Region: PRK08068 681288007222 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 681288007223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288007224 homodimer interface [polypeptide binding]; other site 681288007225 catalytic residue [active] 681288007226 phytoene desaturase; Region: crtI_fam; TIGR02734 681288007227 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288007228 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 681288007229 active site lid residues [active] 681288007230 substrate binding pocket [chemical binding]; other site 681288007231 catalytic residues [active] 681288007232 substrate-Mg2+ binding site; other site 681288007233 aspartate-rich region 1; other site 681288007234 aspartate-rich region 2; other site 681288007235 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 681288007236 active site 681288007237 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 681288007238 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288007239 NlpC/P60 family; Region: NLPC_P60; cl11438 681288007240 OpgC protein; Region: OpgC_C; cl00792 681288007241 Acyltransferase family; Region: Acyl_transf_3; pfam01757 681288007242 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 681288007243 catalytic triad [active] 681288007244 catalytic triad [active] 681288007245 oxyanion hole [active] 681288007246 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 681288007247 Coenzyme A binding pocket [chemical binding]; other site 681288007248 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 681288007249 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 681288007250 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 681288007251 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 681288007252 Helix-turn-helix domains; Region: HTH; cl00088 681288007253 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 681288007254 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 681288007255 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 681288007256 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 681288007257 NmrA-like family; Region: NmrA; pfam05368 681288007258 NADP binding site [chemical binding]; other site 681288007259 active site 681288007260 regulatory binding site [polypeptide binding]; other site 681288007261 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 681288007262 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 681288007263 Helix-turn-helix domains; Region: HTH; cl00088 681288007264 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 681288007265 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288007266 NAD(P) binding site [chemical binding]; other site 681288007267 active site 681288007268 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 681288007269 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 681288007270 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 681288007271 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288007272 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 681288007273 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 681288007274 Nucleoside recognition; Region: Gate; cl00486 681288007275 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 681288007276 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 681288007277 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 681288007278 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 681288007279 Phosphotransferase enzyme family; Region: APH; pfam01636 681288007280 active site 681288007281 substrate binding site [chemical binding]; other site 681288007282 ATP binding site [chemical binding]; other site 681288007283 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 681288007284 quinone interaction residues [chemical binding]; other site 681288007285 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 681288007286 active site 681288007287 catalytic residues [active] 681288007288 FMN binding site [chemical binding]; other site 681288007289 substrate binding site [chemical binding]; other site 681288007290 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 681288007291 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 681288007292 dimer interface [polypeptide binding]; other site 681288007293 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 681288007294 Helix-turn-helix domains; Region: HTH; cl00088 681288007295 Predicted acyl esterases [General function prediction only]; Region: COG2936 681288007296 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 681288007297 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 681288007298 active site 681288007299 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 681288007300 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 681288007301 tetramerization interface [polypeptide binding]; other site 681288007302 active site 681288007303 pantoate--beta-alanine ligase; Region: panC; TIGR00018 681288007304 Pantoate-beta-alanine ligase; Region: PanC; cd00560 681288007305 active site 681288007306 ATP-binding site [chemical binding]; other site 681288007307 pantoate-binding site; other site 681288007308 HXXH motif; other site 681288007309 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 681288007310 oligomerization interface [polypeptide binding]; other site 681288007311 active site 681288007312 metal binding site [ion binding]; metal-binding site 681288007313 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 681288007314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288007315 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 681288007316 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 681288007317 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 681288007318 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 681288007319 tetramer (dimer of dimers) interface [polypeptide binding]; other site 681288007320 NAD binding site [chemical binding]; other site 681288007321 dimer interface [polypeptide binding]; other site 681288007322 substrate binding site [chemical binding]; other site 681288007323 amino acid transporter; Region: 2A0306; TIGR00909 681288007324 Spore germination protein; Region: Spore_permease; cl15802 681288007325 Spore germination protein; Region: Spore_permease; cl15802 681288007326 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 681288007327 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 681288007328 inhibitor-cofactor binding pocket; inhibition site 681288007329 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288007330 catalytic residue [active] 681288007331 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 681288007332 catalytic residue [active] 681288007333 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288007334 Predicted dehydrogenase [General function prediction only]; Region: COG0579 681288007335 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 681288007336 AMP-binding enzyme; Region: AMP-binding; cl15778 681288007337 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 681288007338 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 681288007339 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 681288007340 choline dehydrogenase; Validated; Region: PRK02106 681288007341 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 681288007342 Predicted transcriptional regulators [Transcription]; Region: COG1510 681288007343 BCCT family transporter; Region: BCCT; cl00569 681288007344 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 681288007345 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 681288007346 FeS/SAM binding site; other site 681288007347 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 681288007348 Class III ribonucleotide reductase; Region: RNR_III; cd01675 681288007349 effector binding site; other site 681288007350 active site 681288007351 Zn binding site [ion binding]; other site 681288007352 glycine loop; other site 681288007353 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 681288007354 Citrate transporter; Region: CitMHS; pfam03600 681288007355 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 681288007356 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288007357 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 681288007358 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 681288007359 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 681288007360 FAD binding pocket [chemical binding]; other site 681288007361 FAD binding motif [chemical binding]; other site 681288007362 catalytic residues [active] 681288007363 NAD binding pocket [chemical binding]; other site 681288007364 phosphate binding motif [ion binding]; other site 681288007365 beta-alpha-beta structure motif; other site 681288007366 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 681288007367 catalytic residues [active] 681288007368 dimer interface [polypeptide binding]; other site 681288007369 FtsX-like permease family; Region: FtsX; cl15850 681288007370 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 681288007371 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 681288007372 Walker A/P-loop; other site 681288007373 ATP binding site [chemical binding]; other site 681288007374 Q-loop/lid; other site 681288007375 ABC transporter signature motif; other site 681288007376 Walker B; other site 681288007377 D-loop; other site 681288007378 H-loop/switch region; other site 681288007379 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 681288007380 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 681288007381 ATP binding site [chemical binding]; other site 681288007382 Mg2+ binding site [ion binding]; other site 681288007383 G-X-G motif; other site 681288007384 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 681288007385 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 681288007386 active site 681288007387 phosphorylation site [posttranslational modification] 681288007388 intermolecular recognition site; other site 681288007389 dimerization interface [polypeptide binding]; other site 681288007390 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 681288007391 DNA binding site [nucleotide binding] 681288007392 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 681288007393 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 681288007394 dimer interface [polypeptide binding]; other site 681288007395 active site 681288007396 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 681288007397 Protein of unknown function (DUF2648); Region: DUF2648; pfam10855 681288007398 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 681288007399 Helix-turn-helix domains; Region: HTH; cl00088 681288007400 Predicted esterase [General function prediction only]; Region: COG0627 681288007401 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 681288007402 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 681288007403 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 681288007404 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 681288007405 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 681288007406 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 681288007407 Helix-turn-helix domains; Region: HTH; cl00088 681288007408 carbamate kinase; Reviewed; Region: PRK12686 681288007409 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 681288007410 putative substrate binding site [chemical binding]; other site 681288007411 nucleotide binding site [chemical binding]; other site 681288007412 nucleotide binding site [chemical binding]; other site 681288007413 homodimer interface [polypeptide binding]; other site 681288007414 arginine/ornithine antiporter; Region: arg_ornith_anti; TIGR03810 681288007415 ornithine carbamoyltransferase; Validated; Region: PRK02102 681288007416 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 681288007417 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288007418 Amidinotransferase; Region: Amidinotransf; cl12043 681288007419 Arginine repressor [Transcription]; Region: ArgR; COG1438 681288007420 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 681288007421 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 681288007422 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 681288007423 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 681288007424 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 681288007425 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 681288007426 active site 681288007427 Zn binding site [ion binding]; other site 681288007428 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 681288007429 Transposase; Region: DDE_Tnp_ISL3; pfam01610 681288007430 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 681288007431 Helix-turn-helix domains; Region: HTH; cl00088 681288007432 PRD domain; Region: PRD; cl15445 681288007433 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 681288007434 active site 681288007435 P-loop; other site 681288007436 phosphorylation site [posttranslational modification] 681288007437 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 681288007438 active site 681288007439 phosphorylation site [posttranslational modification] 681288007440 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 681288007441 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 681288007442 active site 681288007443 P-loop; other site 681288007444 phosphorylation site [posttranslational modification] 681288007445 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 681288007446 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 681288007447 active site 681288007448 phosphorylation site [posttranslational modification] 681288007449 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 681288007450 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 681288007451 Predicted membrane protein [Function unknown]; Region: COG1511 681288007452 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 681288007453 ABC-2 type transporter; Region: ABC2_membrane; cl11417 681288007454 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 681288007455 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 681288007456 NlpC/P60 family; Region: NLPC_P60; cl11438 681288007457 Isochorismatase family; Region: Isochorismatase; pfam00857 681288007458 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 681288007459 catalytic triad [active] 681288007460 conserved cis-peptide bond; other site 681288007461 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 681288007462 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 681288007463 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 681288007464 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 681288007465 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 681288007466 accessory Sec system translocase SecA2; Region: secA2; TIGR03714 681288007467 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288007468 ATP binding site [chemical binding]; other site 681288007469 putative Mg++ binding site [ion binding]; other site 681288007470 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 681288007471 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 681288007472 nucleotide binding region [chemical binding]; other site 681288007473 ATP-binding site [chemical binding]; other site 681288007474 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 681288007475 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 681288007476 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 681288007477 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 681288007478 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 681288007479 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 681288007480 SecY translocase; Region: SecY; pfam00344 681288007481 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 681288007482 legume lectins; Region: lectin_L-type; cd01951 681288007483 homotetramer interaction site [polypeptide binding]; other site 681288007484 carbohydrate binding site [chemical binding]; other site 681288007485 metal binding site [ion binding]; metal-binding site 681288007486 Cadherin repeat-like domain; Region: CA_like; cl15786 681288007487 Flavin Reductases; Region: FlaRed; cl00801 681288007488 Flavin Reductases; Region: FlaRed; cl00801 681288007489 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 681288007490 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 681288007491 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 681288007492 Coenzyme A binding pocket [chemical binding]; other site 681288007493 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 681288007494 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 681288007495 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 681288007496 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 681288007497 Chain length determinant protein; Region: Wzz; cl15801 681288007498 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 681288007499 Helix-turn-helix domains; Region: HTH; cl00088 681288007500 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 681288007501 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 681288007502 DXD motif; other site 681288007503 intracellular adhesion protein D; Region: PIA_icaD; TIGR03932 681288007504 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 681288007505 OpgC protein; Region: OpgC_C; cl00792 681288007506 Acyltransferase family; Region: Acyl_transf_3; pfam01757 681288007507 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 681288007508 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 681288007509 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 681288007510 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 681288007511 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 681288007512 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 681288007513 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 681288007514 substrate binding site [chemical binding]; other site 681288007515 glutamase interaction surface [polypeptide binding]; other site 681288007516 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 681288007517 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 681288007518 catalytic residues [active] 681288007519 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 681288007520 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 681288007521 putative active site [active] 681288007522 oxyanion strand; other site 681288007523 catalytic triad [active] 681288007524 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 681288007525 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 681288007526 putative active site pocket [active] 681288007527 4-fold oligomerization interface [polypeptide binding]; other site 681288007528 metal binding residues [ion binding]; metal-binding site 681288007529 3-fold/trimer interface [polypeptide binding]; other site 681288007530 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 681288007531 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 681288007532 pyridoxal 5'-phosphate binding site [chemical binding]; other site 681288007533 homodimer interface [polypeptide binding]; other site 681288007534 catalytic residue [active] 681288007535 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 681288007536 histidinol dehydrogenase; Region: hisD; TIGR00069 681288007537 NAD binding site [chemical binding]; other site 681288007538 dimerization interface [polypeptide binding]; other site 681288007539 product binding site; other site 681288007540 substrate binding site [chemical binding]; other site 681288007541 zinc binding site [ion binding]; other site 681288007542 catalytic residues [active] 681288007543 ATP phosphoribosyltransferase; Region: HisG; cl15266 681288007544 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 681288007545 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 681288007546 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 681288007547 putative active site [active] 681288007548 putative metal binding site [ion binding]; other site 681288007549 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 681288007550 Cobalt transport protein; Region: CbiQ; cl00463 681288007551 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 681288007552 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 681288007553 Walker A/P-loop; other site 681288007554 ATP binding site [chemical binding]; other site 681288007555 Q-loop/lid; other site 681288007556 ABC transporter signature motif; other site 681288007557 Walker B; other site 681288007558 D-loop; other site 681288007559 H-loop/switch region; other site 681288007560 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 681288007561 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 681288007562 Walker A/P-loop; other site 681288007563 ATP binding site [chemical binding]; other site 681288007564 Q-loop/lid; other site 681288007565 ABC transporter signature motif; other site 681288007566 Walker B; other site 681288007567 D-loop; other site 681288007568 H-loop/switch region; other site 681288007569 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 681288007570 Uncharacterized conserved protein [Function unknown]; Region: COG1912 681288007571 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 681288007572 YceI-like domain; Region: YceI; cl01001 681288007573 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 681288007574 Strictosidine synthase; Region: Str_synth; pfam03088 681288007575 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 681288007576 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 681288007577 active site residue [active] 681288007578 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 681288007579 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 681288007580 putative substrate binding pocket [chemical binding]; other site 681288007581 AC domain interface; other site 681288007582 catalytic triad [active] 681288007583 AB domain interface; other site 681288007584 interchain disulfide; other site 681288007585 Helix-turn-helix domains; Region: HTH; cl00088 681288007586 DinB superfamily; Region: DinB_2; pfam12867 681288007587 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 681288007588 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 681288007589 transmembrane helices; other site 681288007590 Predicted permeases [General function prediction only]; Region: RarD; COG2962 681288007591 EamA-like transporter family; Region: EamA; cl01037 681288007592 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 681288007593 High-affinity nickel-transport protein; Region: NicO; cl00964 681288007594 N-acetyltransferase; Region: Acetyltransf_2; cl00949 681288007595 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 681288007596 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 681288007597 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 681288007598 Walker A/P-loop; other site 681288007599 ATP binding site [chemical binding]; other site 681288007600 Q-loop/lid; other site 681288007601 ABC transporter signature motif; other site 681288007602 Walker B; other site 681288007603 D-loop; other site 681288007604 H-loop/switch region; other site 681288007605 FtsX-like permease family; Region: FtsX; cl15850 681288007606 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 681288007607 DNA-binding site [nucleotide binding]; DNA binding site 681288007608 RNA-binding motif; other site 681288007609 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 681288007610 non-specific DNA binding site [nucleotide binding]; other site 681288007611 salt bridge; other site 681288007612 sequence-specific DNA binding site [nucleotide binding]; other site 681288007613 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 681288007614 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 681288007615 ParB-like nuclease domain; Region: ParBc; cl02129 681288007616 ParB-like partition proteins; Region: parB_part; TIGR00180 681288007617 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 681288007618 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 681288007619 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 681288007620 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 681288007621 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 681288007622 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 681288007623 trmE is a tRNA modification GTPase; Region: trmE; cd04164 681288007624 G1 box; other site 681288007625 GTP/Mg2+ binding site [chemical binding]; other site 681288007626 Switch I region; other site 681288007627 G2 box; other site 681288007628 Switch II region; other site 681288007629 G3 box; other site 681288007630 G4 box; other site 681288007631 G5 box; other site 681288007632 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 681288007633 Ribonuclease P; Region: Ribonuclease_P; cl00457 681288007634 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 681288007635 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 681288007636 Replication initiation factor; Region: Rep_trans; pfam02486 681288007637 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 681288007638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 681288007639 putative substrate translocation pore; other site 681288007640 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 681288007641 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 681288007642 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 681288007643 non-specific DNA binding site [nucleotide binding]; other site 681288007644 salt bridge; other site 681288007645 sequence-specific DNA binding site [nucleotide binding]; other site 681288007646 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 681288007647 multiple promoter invertase; Provisional; Region: mpi; PRK13413 681288007648 catalytic residues [active] 681288007649 catalytic nucleophile [active] 681288007650 Presynaptic Site I dimer interface [polypeptide binding]; other site 681288007651 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 681288007652 Synaptic Flat tetramer interface [polypeptide binding]; other site 681288007653 Synaptic Site I dimer interface [polypeptide binding]; other site 681288007654 DNA binding site [nucleotide binding] 681288007655 Helix-turn-helix domains; Region: HTH; cl00088 681288007656 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 681288007657 catalytic nucleophile [active] 681288007658 Integrase core domain; Region: rve; cl01316 681288007659 Integrase core domain; Region: rve_3; cl15866 681288007660 Transposase; Region: DDE_Tnp_ISL3; pfam01610 681288007661 Staphostatin A; Region: Staphostatin_A; pfam09022 681288007662 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 681288007663 Integrase core domain; Region: rve_3; cl15866 681288007664 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 681288007665 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 681288007666 P-loop; other site 681288007667 Magnesium ion binding site [ion binding]; other site 681288007668 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 681288007669 Magnesium ion binding site [ion binding]; other site 681288007670 Helix-turn-helix domains; Region: HTH; cl00088 681288007671 Helix-turn-helix domains; Region: HTH; cl00088 681288007672 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 681288007673 Integrase core domain; Region: rve; cl01316 681288007674 CAAX protease self-immunity; Region: Abi; cl00558 681288007675 PemK-like protein; Region: PemK; cl00995 681288007676 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 681288007677 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 681288007678 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 681288007679 CAAX protease self-immunity; Region: Abi; cl00558