-- dump date 20111121_014818 -- class Genbank::misc_feature -- table misc_feature_note -- id note 418127000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 418127000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 418127000003 Walker A motif; other site 418127000004 ATP binding site [chemical binding]; other site 418127000005 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 418127000006 Walker B motif; other site 418127000007 arginine finger; other site 418127000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 418127000009 DnaA box-binding interface [nucleotide binding]; other site 418127000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 418127000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 418127000012 putative DNA binding surface [nucleotide binding]; other site 418127000013 dimer interface [polypeptide binding]; other site 418127000014 beta-clamp/clamp loader binding surface; other site 418127000015 beta-clamp/translesion DNA polymerase binding surface; other site 418127000016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 418127000017 recombination protein F; Reviewed; Region: recF; PRK00064 418127000018 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 418127000019 Walker A/P-loop; other site 418127000020 ATP binding site [chemical binding]; other site 418127000021 Q-loop/lid; other site 418127000022 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 418127000023 ABC transporter signature motif; other site 418127000024 Walker B; other site 418127000025 D-loop; other site 418127000026 H-loop/switch region; other site 418127000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 418127000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 418127000029 Mg2+ binding site [ion binding]; other site 418127000030 G-X-G motif; other site 418127000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 418127000032 anchoring element; other site 418127000033 dimer interface [polypeptide binding]; other site 418127000034 ATP binding site [chemical binding]; other site 418127000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 418127000036 active site 418127000037 putative metal-binding site [ion binding]; other site 418127000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 418127000039 DNA gyrase subunit A; Validated; Region: PRK05560 418127000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 418127000041 CAP-like domain; other site 418127000042 Active site [active] 418127000043 primary dimer interface [polypeptide binding]; other site 418127000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 418127000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 418127000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 418127000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 418127000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 418127000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 418127000050 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 418127000051 putative substrate binding site [chemical binding]; other site 418127000052 putative ATP binding site [chemical binding]; other site 418127000053 tyrosine 2,3-aminomutase; Region: Tyr_2_3_mutase; TIGR03832 418127000054 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 418127000055 active sites [active] 418127000056 tetramer interface [polypeptide binding]; other site 418127000057 seryl-tRNA synthetase; Provisional; Region: PRK05431 418127000058 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 418127000059 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 418127000060 dimer interface [polypeptide binding]; other site 418127000061 active site 418127000062 motif 1; other site 418127000063 motif 2; other site 418127000064 motif 3; other site 418127000065 AzlC protein; Region: AzlC; cl00570 418127000066 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 418127000067 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 418127000068 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 418127000069 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 418127000070 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 418127000071 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 418127000072 DHH family; Region: DHH; pfam01368 418127000073 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 418127000074 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 418127000075 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 418127000076 replicative DNA helicase; Region: DnaB; TIGR00665 418127000077 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 418127000078 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 418127000079 Walker A motif; other site 418127000080 ATP binding site [chemical binding]; other site 418127000081 Walker B motif; other site 418127000082 DNA binding loops [nucleotide binding] 418127000083 adenylosuccinate synthetase; Provisional; Region: PRK01117 418127000084 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108 418127000085 GDP-binding site [chemical binding]; other site 418127000086 ACT binding site; other site 418127000087 IMP binding site; other site 418127000088 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 418127000089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 418127000090 active site 418127000091 phosphorylation site [posttranslational modification] 418127000092 intermolecular recognition site; other site 418127000093 dimerization interface [polypeptide binding]; other site 418127000094 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 418127000095 DNA binding site [nucleotide binding] 418127000096 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 418127000097 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 418127000098 dimerization interface [polypeptide binding]; other site 418127000099 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 418127000100 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 418127000101 dimer interface [polypeptide binding]; other site 418127000102 phosphorylation site [posttranslational modification] 418127000103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 418127000104 ATP binding site [chemical binding]; other site 418127000105 Mg2+ binding site [ion binding]; other site 418127000106 G-X-G motif; other site 418127000107 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 418127000108 YycH protein; Region: YycH; pfam07435 418127000109 YycH protein; Region: YycI; cl02015 418127000110 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 418127000111 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 418127000112 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 418127000113 putative active site [active] 418127000114 putative metal binding site [ion binding]; other site 418127000115 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 418127000116 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 418127000117 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 418127000118 Integrase core domain; Region: rve; cl01316 418127000119 Replication protein; Region: Rep_1; cl02412 418127000120 Replication protein; Region: Rep_1; cl02412 418127000121 similar to hypothetical protein 418127000122 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 418127000123 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 418127000124 dimer interface [polypeptide binding]; other site 418127000125 ligand binding site [chemical binding]; other site 418127000126 Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cd05397 418127000127 metal binding triad [ion binding]; metal-binding site 418127000128 KNTase C-terminal domain; Region: KNTase_C; pfam07827 418127000129 Integrase core domain; Region: rve; cl01316 418127000130 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 418127000131 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 418127000132 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 418127000133 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 418127000134 putative active site [active] 418127000135 catalytic site [active] 418127000136 putative metal binding site [ion binding]; other site 418127000137 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 418127000138 putative active site [active] 418127000139 putative catalytic site [active] 418127000140 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 418127000141 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 418127000142 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 418127000143 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 418127000144 Peptidase family M48; Region: Peptidase_M48; cl12018 418127000145 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 418127000146 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127000147 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 418127000148 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 418127000149 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 418127000150 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 418127000151 active site residue [active] 418127000152 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 418127000153 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 418127000154 active site residue [active] 418127000155 SirA_RHOD_Pry_redox. SirA-like domain located within a multidomain protein of unknown function. Other domains include RHOD (rhodanese homology domain), and Pry_redox (pyridine nucleotide-disulphide oxidoreductase) as well as a C-terminal domain that...; Region: SirA_RHOD_Pry_redox; cd03420 418127000156 CPxP motif; other site 418127000157 DsrE/DsrF-like family; Region: DrsE; cl00672 418127000158 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 418127000159 putative homotetramer interface [polypeptide binding]; other site 418127000160 putative homodimer interface [polypeptide binding]; other site 418127000161 putative metal binding site [ion binding]; other site 418127000162 putative homodimer-homodimer interface [polypeptide binding]; other site 418127000163 putative allosteric switch controlling residues; other site 418127000164 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 418127000165 S-adenosylmethionine binding site [chemical binding]; other site 418127000166 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 418127000167 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 418127000168 active site 418127000169 NTP binding site [chemical binding]; other site 418127000170 metal binding triad [ion binding]; metal-binding site 418127000171 antibiotic binding site [chemical binding]; other site 418127000172 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 418127000173 Tn544B and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes various bacterial transposases similar to TnpB from transposon Tn554; Region: INT_Tn544B_C; cd01195 418127000174 Phage integrase family; Region: Phage_integrase; pfam00589 418127000175 Int/Topo IB signature motif; other site 418127000176 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 418127000177 Phage integrase family; Region: Phage_integrase; pfam00589 418127000178 Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194 418127000179 Int/Topo IB signature motif; other site 418127000180 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 418127000181 MPN+ (JAMM) motif; other site 418127000182 Zinc-binding site [ion binding]; other site 418127000183 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 418127000184 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 418127000185 Staphylococcus protein of unknown function (DUF950); Region: DUF950; pfam06106 418127000186 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 418127000187 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 418127000188 catalytic residues [active] 418127000189 catalytic nucleophile [active] 418127000190 Presynaptic Site I dimer interface [polypeptide binding]; other site 418127000191 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 418127000192 Synaptic Flat tetramer interface [polypeptide binding]; other site 418127000193 Synaptic Site I dimer interface [polypeptide binding]; other site 418127000194 DNA binding site [nucleotide binding] 418127000195 Recombinase; Region: Recombinase; pfam07508 418127000196 Ogr/Delta-like zinc finger; Region: Ogr_Delta; cl04623 418127000197 Transcription factor/nuclear export subunit protein 2; Region: Tho2; pfam11262 418127000198 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 418127000199 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 418127000200 catalytic residues [active] 418127000201 catalytic nucleophile [active] 418127000202 Recombinase; Region: Recombinase; pfam07508 418127000203 Domain of unknown function (DUF927); Region: DUF927; cl12098 418127000204 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 418127000205 Integrase core domain; Region: rve; cl01316 418127000206 putative transposase OrfB; Reviewed; Region: PHA02517 418127000207 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 418127000208 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 418127000209 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 418127000210 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 418127000211 active site 418127000212 phosphorylation site [posttranslational modification] 418127000213 intermolecular recognition site; other site 418127000214 dimerization interface [polypeptide binding]; other site 418127000215 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 418127000216 DNA binding site [nucleotide binding] 418127000217 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 418127000218 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 418127000219 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 418127000220 Ligand Binding Site [chemical binding]; other site 418127000221 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 418127000222 dimer interface [polypeptide binding]; other site 418127000223 phosphorylation site [posttranslational modification] 418127000224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 418127000225 ATP binding site [chemical binding]; other site 418127000226 Mg2+ binding site [ion binding]; other site 418127000227 G-X-G motif; other site 418127000228 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; cl00903 418127000229 Potassium-transporting ATPase A subunit; Region: KdpA; pfam03814 418127000230 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 418127000231 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 418127000232 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 418127000233 K+-transporting ATPase, c chain; Region: KdpC; cl00944 418127000234 Domain of unknown function (DUF927); Region: DUF927; cl12098 418127000235 Protein kinase domain; Region: Pkinase; pfam00069 418127000236 Catalytic domain of Protein Kinases; Region: PKc; cd00180 418127000237 active site 418127000238 ATP binding site [chemical binding]; other site 418127000239 substrate binding site [chemical binding]; other site 418127000240 activation loop (A-loop); other site 418127000241 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 418127000242 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 418127000243 phosphate binding site [ion binding]; other site 418127000244 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 418127000245 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 418127000246 putative homotetramer interface [polypeptide binding]; other site 418127000247 putative homodimer interface [polypeptide binding]; other site 418127000248 putative metal binding site [ion binding]; other site 418127000249 putative homodimer-homodimer interface [polypeptide binding]; other site 418127000250 putative allosteric switch controlling residues; other site 418127000251 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 418127000252 active site residue [active] 418127000253 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-...; Region: SirA_YedF_YeeD; cl00436 418127000254 CPxP motif; other site 418127000255 DsrE/DsrF-like family; Region: DrsE; cl00672 418127000256 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 418127000257 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 418127000258 active site residue [active] 418127000259 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 418127000260 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 418127000261 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 418127000262 FMN binding site [chemical binding]; other site 418127000263 active site 418127000264 catalytic residues [active] 418127000265 substrate binding site [chemical binding]; other site 418127000266 TfoX N-terminal domain; Region: TfoX_N; cl01167 418127000267 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 418127000268 UvrD/REP helicase; Region: UvrD-helicase; cl14126 418127000269 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 418127000270 active site 418127000271 catalytic site [active] 418127000272 putative metal binding site [ion binding]; other site 418127000273 Protein of unknown function, DUF576; Region: DUF576; cl04553 418127000274 Protein of unknown function, DUF576; Region: DUF576; cl04553 418127000275 Protein of unknown function, DUF576; Region: DUF576; cl04553 418127000276 Protein of unknown function, DUF576; Region: DUF576; cl04553 418127000277 Protein of unknown function, DUF576; Region: DUF576; cl04553 418127000278 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 418127000279 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 418127000280 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; cl10042 418127000281 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 418127000282 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 418127000283 metal binding site [ion binding]; metal-binding site 418127000284 dimer interface [polypeptide binding]; other site 418127000285 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127000286 Major Facilitator Superfamily; Region: MFS_1; pfam07690 418127000287 putative substrate translocation pore; other site 418127000288 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127000289 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 418127000290 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 418127000291 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 418127000292 PhoU domain; Region: PhoU; pfam01895 418127000293 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 418127000294 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl01939 418127000295 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 418127000296 EamA-like transporter family; Region: EamA; cl01037 418127000297 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 418127000298 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 418127000299 DNA-binding site [nucleotide binding]; DNA binding site 418127000300 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 418127000301 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127000302 homodimer interface [polypeptide binding]; other site 418127000303 catalytic residue [active] 418127000304 Protein of unknown function (DUF1648); Region: DUF1648; cl01712 418127000305 glycolate transporter; Provisional; Region: PRK09695 418127000306 L-lactate permease; Region: Lactate_perm; cl00701 418127000307 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 418127000308 B domain; Region: B; pfam02216 418127000309 B domain; Region: B; pfam02216 418127000310 B domain; Region: B; pfam02216 418127000311 B domain; Region: B; pfam02216 418127000312 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 418127000313 putative peptidoglycan binding site; other site 418127000314 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127000315 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127000316 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 418127000317 ABC-ATPase subunit interface; other site 418127000318 dimer interface [polypeptide binding]; other site 418127000319 putative PBP binding regions; other site 418127000320 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 418127000321 ABC-ATPase subunit interface; other site 418127000322 dimer interface [polypeptide binding]; other site 418127000323 putative PBP binding regions; other site 418127000324 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 418127000325 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor...; Region: FhuD; cd01146 418127000326 siderophore binding site; other site 418127000327 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 418127000328 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 418127000329 dimer interface [polypeptide binding]; other site 418127000330 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127000331 catalytic residue [active] 418127000332 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127000333 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 418127000334 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 418127000335 IucA / IucC family; Region: IucA_IucC; pfam04183 418127000336 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 418127000337 drug efflux system protein MdtG; Provisional; Region: PRK09874 418127000338 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127000339 putative substrate translocation pore; other site 418127000340 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 418127000341 IucA / IucC family; Region: IucA_IucC; pfam04183 418127000342 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 418127000343 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 418127000344 IucA / IucC family; Region: IucA_IucC; pfam04183 418127000345 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 418127000346 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 418127000347 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 418127000348 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 418127000349 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 418127000350 dimer interface [polypeptide binding]; other site 418127000351 active site 418127000352 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 418127000353 catalytic residues [active] 418127000354 substrate binding site [chemical binding]; other site 418127000355 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 418127000356 ParB-like nuclease domain; Region: ParBc; cl02129 418127000357 acetoin reductase; Validated; Region: PRK08643 418127000358 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 418127000359 NAD binding site [chemical binding]; other site 418127000360 homotetramer interface [polypeptide binding]; other site 418127000361 homodimer interface [polypeptide binding]; other site 418127000362 active site 418127000363 substrate binding site [chemical binding]; other site 418127000364 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127000365 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 418127000366 NAD(P) binding site [chemical binding]; other site 418127000367 active site 418127000368 Bacterial sugar transferase; Region: Bac_transf; cl00939 418127000369 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 418127000370 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 418127000371 putative ADP-binding pocket [chemical binding]; other site 418127000372 O-Antigen Polymerase; Region: Wzy_C; cl04850 418127000373 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 418127000374 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 418127000375 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 418127000376 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 418127000377 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 418127000378 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 418127000379 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 418127000380 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 418127000381 DNA-binding site [nucleotide binding]; DNA binding site 418127000382 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 418127000383 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 418127000384 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 418127000385 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 418127000386 intersubunit interface [polypeptide binding]; other site 418127000387 active site 418127000388 catalytic residue [active] 418127000389 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 418127000390 Sulfatase; Region: Sulfatase; cl10460 418127000391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 418127000392 dimer interface [polypeptide binding]; other site 418127000393 conserved gate region; other site 418127000394 putative PBP binding loops; other site 418127000395 ABC-ATPase subunit interface; other site 418127000396 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 418127000397 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 418127000398 dimer interface [polypeptide binding]; other site 418127000399 conserved gate region; other site 418127000400 ABC-ATPase subunit interface; other site 418127000401 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 418127000402 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 418127000403 Walker A/P-loop; other site 418127000404 ATP binding site [chemical binding]; other site 418127000405 Q-loop/lid; other site 418127000406 ABC transporter signature motif; other site 418127000407 Walker B; other site 418127000408 D-loop; other site 418127000409 H-loop/switch region; other site 418127000410 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 418127000411 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 418127000412 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 418127000413 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 418127000414 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 418127000415 active site 418127000416 metal binding site [ion binding]; metal-binding site 418127000417 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 418127000418 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 418127000419 non-specific DNA binding site [nucleotide binding]; other site 418127000420 salt bridge; other site 418127000421 sequence-specific DNA binding site [nucleotide binding]; other site 418127000422 Domain of unknown function (DUF955); Region: DUF955; cl01076 418127000423 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 418127000424 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 418127000425 putative catalytic cysteine [active] 418127000426 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 418127000427 putative active site [active] 418127000428 metal binding site [ion binding]; metal-binding site 418127000429 Chain length determinant protein; Region: Wzz; cl01623 418127000430 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 418127000431 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 418127000432 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 418127000433 PHP domain; Region: PHP; pfam02811 418127000434 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 418127000435 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 418127000436 NAD(P) binding site [chemical binding]; other site 418127000437 homodimer interface [polypeptide binding]; other site 418127000438 substrate binding site [chemical binding]; other site 418127000439 active site 418127000440 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 418127000441 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 418127000442 NAD(P) binding site [chemical binding]; other site 418127000443 homodimer interface [polypeptide binding]; other site 418127000444 substrate binding site [chemical binding]; other site 418127000445 active site 418127000446 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 418127000447 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 418127000448 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 418127000449 putative NAD(P) binding site [chemical binding]; other site 418127000450 active site 418127000451 putative substrate binding site [chemical binding]; other site 418127000452 Cupin domain; Region: Cupin_2; cl09118 418127000453 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 418127000454 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues...; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 418127000455 active site 418127000456 homodimer interface [polypeptide binding]; other site 418127000457 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 418127000458 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 418127000459 trimer interface [polypeptide binding]; other site 418127000460 active site 418127000461 substrate binding site [chemical binding]; other site 418127000462 CoA binding site [chemical binding]; other site 418127000463 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 418127000464 O-Antigen ligase; Region: Wzy_C; cl04850 418127000465 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 418127000466 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 418127000467 Bacterial sugar transferase; Region: Bac_transf; cl00939 418127000468 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 418127000469 putative NAD(P) binding site [chemical binding]; other site 418127000470 active site 418127000471 putative substrate binding site [chemical binding]; other site 418127000472 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 418127000473 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 418127000474 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 418127000475 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 418127000476 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues...; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 418127000477 active site 418127000478 homodimer interface [polypeptide binding]; other site 418127000479 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 418127000480 Protein of unknown function (DUF454); Region: DUF454; cl01063 418127000481 Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117 418127000482 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 418127000483 NAD(P) binding site [chemical binding]; other site 418127000484 catalytic residues [active] 418127000485 Cation efflux family; Region: Cation_efflux; cl00316 418127000486 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 418127000487 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 418127000488 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 418127000489 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 418127000490 Walker A/P-loop; other site 418127000491 ATP binding site [chemical binding]; other site 418127000492 Q-loop/lid; other site 418127000493 ABC transporter signature motif; other site 418127000494 Walker B; other site 418127000495 D-loop; other site 418127000496 H-loop/switch region; other site 418127000497 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 418127000498 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 418127000499 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 418127000500 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 418127000501 active site 418127000502 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 418127000503 formate dehydrogenase; Provisional; Region: PRK07574 418127000504 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127000505 putative transporter; Provisional; Region: PRK10054 418127000506 Condensation domain; Region: Condensation; cl09290 418127000507 peptide synthase; Provisional; Region: PRK12467 418127000508 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 418127000509 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 418127000510 Phosphopantetheine attachment site; Region: PP-binding; cl09936 418127000511 Condensation domain; Region: Condensation; cl09290 418127000512 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 418127000513 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 418127000514 Phosphopantetheine attachment site; Region: PP-binding; cl09936 418127000515 thioester reductase domain; Region: Thioester-redct; TIGR01746 418127000516 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127000517 NAD(P) binding site [chemical binding]; other site 418127000518 active site 418127000519 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 418127000520 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 418127000521 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 418127000522 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 418127000523 nucleotide binding site [chemical binding]; other site 418127000524 N-acetyl-L-glutamate binding site [chemical binding]; other site 418127000525 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group...; Region: OAT; cd02152 418127000526 heterotetramer interface [polypeptide binding]; other site 418127000527 active site pocket [active] 418127000528 cleavage site 418127000529 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 418127000530 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127000531 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 418127000532 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 418127000533 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 418127000534 inhibitor-cofactor binding pocket; inhibition site 418127000535 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127000536 catalytic residue [active] 418127000537 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 418127000538 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 418127000539 catalytic triad [active] 418127000540 conserved cis-peptide bond; other site 418127000541 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 418127000542 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 418127000543 dimer interface [polypeptide binding]; other site 418127000544 PYR/PP interface [polypeptide binding]; other site 418127000545 TPP binding site [chemical binding]; other site 418127000546 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 418127000547 TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of pyruvate to acetaldehyde and CO2. It is able to utilize...; Region: TPP_PDC_IPDC; cd02005 418127000548 TPP-binding site [chemical binding]; other site 418127000549 dimer interface [polypeptide binding]; other site 418127000550 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 418127000551 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 418127000552 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 418127000553 active site turn [active] 418127000554 phosphorylation site [posttranslational modification] 418127000555 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cd00210 418127000556 HPr interaction site; other site 418127000557 glycerol kinase (GK) interaction site [polypeptide binding]; other site 418127000558 active site 418127000559 phosphorylation site [posttranslational modification] 418127000560 Uncharacterized conserved protein [Function unknown]; Region: COG3589 418127000561 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 418127000562 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 418127000563 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 418127000564 putative active site [active] 418127000565 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 418127000566 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 418127000567 active site turn [active] 418127000568 phosphorylation site [posttranslational modification] 418127000569 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 418127000570 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 418127000571 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 418127000572 putative active site [active] 418127000573 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 418127000574 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 418127000575 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 418127000576 ATP binding site [chemical binding]; other site 418127000577 putative Mg++ binding site [ion binding]; other site 418127000578 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 418127000579 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 418127000580 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 418127000581 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 418127000582 Walker A/P-loop; other site 418127000583 ATP binding site [chemical binding]; other site 418127000584 Q-loop/lid; other site 418127000585 ABC transporter signature motif; other site 418127000586 Walker B; other site 418127000587 D-loop; other site 418127000588 H-loop/switch region; other site 418127000589 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 418127000590 FtsX-like permease family; Region: FtsX; pfam02687 418127000591 Integral membrane protein DUF95; Region: DUF95; cl00572 418127000592 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 418127000593 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 418127000594 Walker A/P-loop; other site 418127000595 ATP binding site [chemical binding]; other site 418127000596 Q-loop/lid; other site 418127000597 ABC transporter signature motif; other site 418127000598 Walker B; other site 418127000599 D-loop; other site 418127000600 H-loop/switch region; other site 418127000601 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 418127000602 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 418127000603 Walker A/P-loop; other site 418127000604 ATP binding site [chemical binding]; other site 418127000605 Q-loop/lid; other site 418127000606 ABC transporter signature motif; other site 418127000607 Walker B; other site 418127000608 D-loop; other site 418127000609 H-loop/switch region; other site 418127000610 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 418127000611 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 418127000612 Walker A/P-loop; other site 418127000613 ATP binding site [chemical binding]; other site 418127000614 Q-loop/lid; other site 418127000615 ABC transporter signature motif; other site 418127000616 Walker B; other site 418127000617 D-loop; other site 418127000618 H-loop/switch region; other site 418127000619 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 418127000620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 418127000621 dimer interface [polypeptide binding]; other site 418127000622 conserved gate region; other site 418127000623 putative PBP binding loops; other site 418127000624 ABC-ATPase subunit interface; other site 418127000625 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 418127000626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 418127000627 dimer interface [polypeptide binding]; other site 418127000628 conserved gate region; other site 418127000629 ABC-ATPase subunit interface; other site 418127000630 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 418127000631 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 418127000632 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 418127000633 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 418127000634 Protein of unknown function, DUF576; Region: DUF576; cl04553 418127000635 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 418127000636 Peptidase family M23; Region: Peptidase_M23; pfam01551 418127000637 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 418127000638 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 418127000639 Walker A/P-loop; other site 418127000640 ATP binding site [chemical binding]; other site 418127000641 Q-loop/lid; other site 418127000642 ABC transporter signature motif; other site 418127000643 Walker B; other site 418127000644 D-loop; other site 418127000645 H-loop/switch region; other site 418127000646 TOBE domain; Region: TOBE_2; cl01440 418127000647 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 418127000648 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 418127000649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 418127000650 dimer interface [polypeptide binding]; other site 418127000651 conserved gate region; other site 418127000652 ABC-ATPase subunit interface; other site 418127000653 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 418127000654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 418127000655 dimer interface [polypeptide binding]; other site 418127000656 conserved gate region; other site 418127000657 putative PBP binding loops; other site 418127000658 ABC-ATPase subunit interface; other site 418127000659 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 418127000660 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127000661 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 418127000662 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 418127000663 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127000664 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 418127000665 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 418127000666 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 418127000667 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127000668 putative substrate translocation pore; other site 418127000669 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127000670 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 418127000671 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 418127000672 active site 418127000673 phosphorylation site [posttranslational modification] 418127000674 intermolecular recognition site; other site 418127000675 dimerization interface [polypeptide binding]; other site 418127000676 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 418127000677 Histidine kinase; Region: His_kinase; pfam06580 418127000678 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 418127000679 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 418127000680 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 418127000681 Pyruvate formate lyase 1; Region: PFL1; cd01678 418127000682 coenzyme A binding site [chemical binding]; other site 418127000683 active site 418127000684 catalytic residues [active] 418127000685 glycine loop; other site 418127000686 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 418127000687 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 418127000688 FeS/SAM binding site; other site 418127000689 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 418127000690 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 418127000691 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 418127000692 putative active site [active] 418127000693 catalytic site [active] 418127000694 putative metal binding site [ion binding]; other site 418127000695 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 418127000696 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 418127000697 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 418127000698 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 418127000699 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 418127000700 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 418127000701 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 418127000702 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 418127000703 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 418127000704 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 418127000705 dimer interface [polypeptide binding]; other site 418127000706 active site 418127000707 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 418127000708 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127000709 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 418127000710 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 418127000711 substrate binding site [chemical binding]; other site 418127000712 oxyanion hole (OAH) forming residues; other site 418127000713 trimer interface [polypeptide binding]; other site 418127000714 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 418127000715 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 418127000716 active site 418127000717 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 418127000718 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 418127000719 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 418127000720 Coenzyme A transferase; Region: CoA_trans; cl00773 418127000721 Coenzyme A transferase; Region: CoA_trans; cl00773 418127000722 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 418127000723 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 418127000724 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 418127000725 Protein of unknown function, DUF488; Region: DUF488; cl01246 418127000726 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 418127000727 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 418127000728 heme-binding site [chemical binding]; other site 418127000729 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 418127000730 FAD binding pocket [chemical binding]; other site 418127000731 FAD binding motif [chemical binding]; other site 418127000732 phosphate binding motif [ion binding]; other site 418127000733 beta-alpha-beta structure motif; other site 418127000734 NAD binding pocket [chemical binding]; other site 418127000735 Heme binding pocket [chemical binding]; other site 418127000736 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 418127000737 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 418127000738 tetramer (dimer of dimers) interface [polypeptide binding]; other site 418127000739 NAD binding site [chemical binding]; other site 418127000740 dimer interface [polypeptide binding]; other site 418127000741 substrate binding site [chemical binding]; other site 418127000742 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 418127000743 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 418127000744 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 418127000745 active site turn [active] 418127000746 phosphorylation site [posttranslational modification] 418127000747 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 418127000748 active site 418127000749 tetramer interface [polypeptide binding]; other site 418127000750 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 418127000751 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127000752 PRD domain; Region: PRD; pfam00874 418127000753 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 418127000754 P-loop; other site 418127000755 active site 418127000756 phosphorylation site [posttranslational modification] 418127000757 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 418127000758 active site 418127000759 phosphorylation site [posttranslational modification] 418127000760 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 418127000761 active site 418127000762 phosphorylation site [posttranslational modification] 418127000763 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 418127000764 P-loop; other site 418127000765 active site 418127000766 phosphorylation site [posttranslational modification] 418127000767 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 418127000768 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 418127000769 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 418127000770 putative NAD(P) binding site [chemical binding]; other site 418127000771 catalytic Zn binding site [ion binding]; other site 418127000772 structural Zn binding site [ion binding]; other site 418127000773 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 418127000774 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 418127000775 putative NAD(P) binding site [chemical binding]; other site 418127000776 catalytic Zn binding site [ion binding]; other site 418127000777 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 418127000778 substrate binding site [chemical binding]; other site 418127000779 dimer interface [polypeptide binding]; other site 418127000780 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 418127000781 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 418127000782 putative NAD(P) binding site [chemical binding]; other site 418127000783 putative catalytic Zn binding site [ion binding]; other site 418127000784 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 418127000785 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 418127000786 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 418127000787 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 418127000788 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 418127000789 substrate binding site [chemical binding]; other site 418127000790 dimer interface [polypeptide binding]; other site 418127000791 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 418127000792 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 418127000793 putative NAD(P) binding site [chemical binding]; other site 418127000794 putative catalytic Zn binding site [ion binding]; other site 418127000795 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 418127000796 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 418127000797 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 418127000798 active site 418127000799 cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276 418127000800 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 418127000801 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 418127000802 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 418127000803 Histidine kinase; Region: His_kinase; pfam06580 418127000804 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 418127000805 two-component response regulator; Provisional; Region: PRK14084 418127000806 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 418127000807 active site 418127000808 phosphorylation site [posttranslational modification] 418127000809 intermolecular recognition site; other site 418127000810 dimerization interface [polypeptide binding]; other site 418127000811 LytTr DNA-binding domain; Region: LytTR; cl04498 418127000812 LrgA family; Region: LrgA; cl00608 418127000813 LrgB-like family; Region: LrgB; cl00596 418127000814 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 418127000815 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 418127000816 DNA-binding site [nucleotide binding]; DNA binding site 418127000817 UTRA domain; Region: UTRA; cl06649 418127000818 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cl00164 418127000819 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162 418127000820 HPr interaction site; other site 418127000821 glycerol kinase (GK) interaction site [polypeptide binding]; other site 418127000822 active site 418127000823 phosphorylation site [posttranslational modification] 418127000824 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 418127000825 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 418127000826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 418127000827 S-adenosylmethionine binding site [chemical binding]; other site 418127000828 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of...; Region: ribokinase; cd01174 418127000829 substrate binding site [chemical binding]; other site 418127000830 dimer interface [polypeptide binding]; other site 418127000831 ATP binding site [chemical binding]; other site 418127000832 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 418127000833 Sugar transport protein; Region: Sugar_transport; pfam06800 418127000834 Transcriptional regulators [Transcription]; Region: PurR; COG1609 418127000835 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 418127000836 DNA binding site [nucleotide binding] 418127000837 domain linker motif; other site 418127000838 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 418127000839 dimerization interface [polypeptide binding]; other site 418127000840 ligand binding site [chemical binding]; other site 418127000841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127000842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127000843 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 418127000844 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-...; Region: Ntn_PVA; cd00542 418127000845 active site 418127000846 Surface antigen [General function prediction only]; Region: COG3942 418127000847 Peptidase family M23; Region: Peptidase_M23; pfam01551 418127000848 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 418127000849 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 418127000850 Walker A/P-loop; other site 418127000851 ATP binding site [chemical binding]; other site 418127000852 Q-loop/lid; other site 418127000853 ABC transporter signature motif; other site 418127000854 Walker B; other site 418127000855 D-loop; other site 418127000856 H-loop/switch region; other site 418127000857 Surface antigen [General function prediction only]; Region: COG3942 418127000858 NlpC/P60 family; Region: NLPC_P60; cl11438 418127000859 Proteins of 100 residues with WXG; Region: WXG100; cl02005 418127000860 Predicted membrane protein [Function unknown]; Region: COG1511 418127000861 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 418127000862 ABC-2 type transporter; Region: ABC2_membrane; cl11417 418127000863 Firmicute eSAT-6 protein secretion system EssA; Region: EssA; cl11266 418127000864 YukD; Region: YukD; cl11566 418127000865 Predicted membrane protein essB; Region: essB; cl01868 418127000866 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 418127000867 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 418127000868 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 418127000869 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 418127000870 Virulence factor EsxB; Region: EsxB; pfam10663 418127000871 Uncharacterized conserved protein [Function unknown]; Region: COG5444 418127000872 Protein of unknown function, DUF600; Region: DUF600; cl04640 418127000873 Protein of unknown function, DUF600; Region: DUF600; cl04640 418127000874 Protein of unknown function, DUF600; Region: DUF600; cl04640 418127000875 Protein of unknown function, DUF600; Region: DUF600; cl04640 418127000876 Protein of unknown function, DUF600; Region: DUF600; cl04640 418127000877 Protein of unknown function, DUF600; Region: DUF600; cl04640 418127000878 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 418127000879 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 418127000880 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 418127000881 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 418127000882 FtsX-like permease family; Region: FtsX; pfam02687 418127000883 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 418127000884 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 418127000885 Walker A/P-loop; other site 418127000886 ATP binding site [chemical binding]; other site 418127000887 Q-loop/lid; other site 418127000888 ABC transporter signature motif; other site 418127000889 Walker B; other site 418127000890 D-loop; other site 418127000891 H-loop/switch region; other site 418127000892 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 418127000893 putative kinase; Provisional; Region: PRK09954 418127000894 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127000895 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 418127000896 substrate binding site [chemical binding]; other site 418127000897 ATP binding site [chemical binding]; other site 418127000898 Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983 418127000899 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 418127000900 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 418127000901 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 418127000902 Sodium:solute symporter family; Region: SSF; cl00456 418127000903 putative transporter; Provisional; Region: PRK10484 418127000904 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 418127000905 N-acetylneuraminate lyase; Region: nanA; TIGR00683 418127000906 inhibitor site; inhibition site 418127000907 active site 418127000908 dimer interface [polypeptide binding]; other site 418127000909 catalytic residue [active] 418127000910 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 418127000911 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 418127000912 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 418127000913 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 418127000914 putative active site [active] 418127000915 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 418127000916 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family...; Region: NanE; cd04729 418127000917 putative active site cavity [active] 418127000918 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 418127000919 Nucleoside recognition; Region: Gate; cl00486 418127000920 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 418127000921 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 418127000922 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 418127000923 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 418127000924 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 418127000925 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 418127000926 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 418127000927 putative active site [active] 418127000928 putative FMN binding site [chemical binding]; other site 418127000929 putative substrate binding site [chemical binding]; other site 418127000930 putative catalytic residue [active] 418127000931 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 418127000932 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 418127000933 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 418127000934 lipoyl attachment site [posttranslational modification]; other site 418127000935 Replication protein C N-terminal domain; Region: RP-C; pfam03428 418127000936 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_1; cd02906 418127000937 putative ADP-ribose binding site [chemical binding]; other site 418127000938 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cd00296 418127000939 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 418127000940 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 418127000941 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 418127000942 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 418127000943 cinnamoyl-CoA reductase; Region: PLN02214 418127000944 NADP binding site [chemical binding]; other site 418127000945 putative substrate binding site [chemical binding]; other site 418127000946 active site 418127000947 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 418127000948 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 418127000949 P-loop; other site 418127000950 active site 418127000951 phosphorylation site [posttranslational modification] 418127000952 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 418127000953 active site 418127000954 phosphorylation site [posttranslational modification] 418127000955 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 418127000956 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127000957 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127000958 PRD domain; Region: PRD; pfam00874 418127000959 PRD domain; Region: PRD; pfam00874 418127000960 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 418127000961 P-loop; other site 418127000962 active site 418127000963 phosphorylation site [posttranslational modification] 418127000964 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 418127000965 active site 418127000966 phosphorylation site [posttranslational modification] 418127000967 Transcriptional regulators [Transcription]; Region: MarR; COG1846 418127000968 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127000969 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 418127000970 MatE; Region: MatE; pfam01554 418127000971 MatE; Region: MatE; pfam01554 418127000972 MepB protein; Region: MepB; cl01985 418127000973 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 418127000974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127000975 putative substrate translocation pore; other site 418127000976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127000977 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 418127000978 Zn binding site [ion binding]; other site 418127000979 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 418127000980 Zn binding site [ion binding]; other site 418127000981 CE1758 family; Region: LLM_CE1758_fam; TIGR04036 418127000982 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 418127000983 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 418127000984 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 418127000985 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 418127000986 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 418127000987 Imelysin; Region: Peptidase_M75; cl09159 418127000988 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 418127000989 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 418127000990 Iron permease FTR1 family; Region: FTR1; cl00475 418127000991 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 418127000992 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 418127000993 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 418127000994 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 418127000995 non-specific DNA binding site [nucleotide binding]; other site 418127000996 salt bridge; other site 418127000997 sequence-specific DNA binding site [nucleotide binding]; other site 418127000998 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 418127000999 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 418127001000 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 418127001001 Walker A/P-loop; other site 418127001002 ATP binding site [chemical binding]; other site 418127001003 Q-loop/lid; other site 418127001004 ABC transporter signature motif; other site 418127001005 Walker B; other site 418127001006 D-loop; other site 418127001007 H-loop/switch region; other site 418127001008 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 418127001009 putative acyltransferase; Provisional; Region: PRK05790 418127001010 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 418127001011 dimer interface [polypeptide binding]; other site 418127001012 active site 418127001013 Putative cyclase; Region: Cyclase; cl00814 418127001014 N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_N_terminal_like; cd03312 418127001015 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371 418127001016 THF binding site; other site 418127001017 C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311 418127001018 substrate binding site [chemical binding]; other site 418127001019 THF binding site; other site 418127001020 zinc-binding site [ion binding]; other site 418127001021 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 418127001022 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105 418127001023 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537 418127001024 FAD binding site [chemical binding]; other site 418127001025 cystathionine beta-lyase; Provisional; Region: PRK08064 418127001026 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 418127001027 homodimer interface [polypeptide binding]; other site 418127001028 substrate-cofactor binding pocket; other site 418127001029 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127001030 catalytic residue [active] 418127001031 cystathionine gamma-synthase; Reviewed; Region: PRK08247 418127001032 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 418127001033 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 418127001034 catalytic residue [active] 418127001035 ParB-like partition proteins; Region: parB_part; TIGR00180 418127001036 ParB-like nuclease domain; Region: ParBc; cl02129 418127001037 Mechanosensitive ion channel; Region: MS_channel; pfam00924 418127001038 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 418127001039 GTP-binding protein YchF; Reviewed; Region: PRK09601 418127001040 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 418127001041 G1 box; other site 418127001042 GTP/Mg2+ binding site [chemical binding]; other site 418127001043 Switch I region; other site 418127001044 G2 box; other site 418127001045 Switch II region; other site 418127001046 G3 box; other site 418127001047 G4 box; other site 418127001048 G5 box; other site 418127001049 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 418127001050 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 418127001051 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 418127001052 dimer interface [polypeptide binding]; other site 418127001053 ssDNA binding site [nucleotide binding]; other site 418127001054 tetramer (dimer of dimers) interface [polypeptide binding]; other site 418127001055 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 418127001056 Abi-like protein; Region: Abi_2; cl01988 418127001057 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 418127001058 DNA binding site [nucleotide binding] 418127001059 active site 418127001060 Int/Topo IB signature motif; other site 418127001061 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127001062 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 418127001063 Predicted membrane protein [Function unknown]; Region: COG3212 418127001064 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 418127001065 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 418127001066 catalytic core [active] 418127001067 extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502 418127001068 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 418127001069 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the...; Region: AhpF_NTD_N; cd02974 418127001070 catalytic residue [active] 418127001071 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 418127001072 catalytic residues [active] 418127001073 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 418127001074 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 418127001075 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 418127001076 peroxiredoxin; Region: AhpC; TIGR03137 418127001077 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic...; Region: PRX_Typ2cys; cd03015 418127001078 dimer interface [polypeptide binding]; other site 418127001079 decamer (pentamer of dimers) interface [polypeptide binding]; other site 418127001080 catalytic triad [active] 418127001081 peroxidatic and resolving cysteines [active] 418127001082 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH...; Region: NfsA_FRP; cd02146 418127001083 dimer interface [polypeptide binding]; other site 418127001084 FMN binding site [chemical binding]; other site 418127001085 NADPH bind site [chemical binding]; other site 418127001086 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 418127001087 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 418127001088 Transposase; Region: DDE_Tnp_ISL3; pfam01610 418127001089 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 418127001090 Permease family; Region: Xan_ur_permease; pfam00860 418127001091 Sulfate transporter family; Region: Sulfate_transp; cl00967 418127001092 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 418127001093 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 418127001094 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 418127001095 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 418127001096 active site 418127001097 GMP synthase; Reviewed; Region: guaA; PRK00074 418127001098 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 418127001099 AMP/PPi binding site [chemical binding]; other site 418127001100 candidate oxyanion hole; other site 418127001101 catalytic triad [active] 418127001102 potential glutamine specificity residues [chemical binding]; other site 418127001103 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 418127001104 ATP Binding subdomain [chemical binding]; other site 418127001105 Ligand Binding sites [chemical binding]; other site 418127001106 Dimerization subdomain; other site 418127001107 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 418127001108 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 418127001109 Int/Topo IB signature motif; other site 418127001110 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 418127001111 Helix-turn-helix domain; Region: HTH_16; pfam12645 418127001112 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 418127001113 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 418127001114 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 418127001115 non-specific DNA binding site [nucleotide binding]; other site 418127001116 salt bridge; other site 418127001117 sequence-specific DNA binding site [nucleotide binding]; other site 418127001118 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 418127001119 Tet(M)-like subfamily. Tet(M), Tet(O), Tet(W), and OtrA are tetracycline resistance genes found in Gram-positive and Gram-negative bacteria. Tetracyclines inhibit protein synthesis by preventing aminoacyl-tRNA from binding to the ribosomal acceptor...; Region: TetM_like; cd04168 418127001120 G1 box; other site 418127001121 putative GEF interaction site [polypeptide binding]; other site 418127001122 GTP/Mg2+ binding site [chemical binding]; other site 418127001123 Switch I region; other site 418127001124 G2 box; other site 418127001125 G3 box; other site 418127001126 Switch II region; other site 418127001127 G4 box; other site 418127001128 G5 box; other site 418127001129 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 418127001130 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines...; Region: Tet_like_IV; cd01684 418127001131 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a GTP-...; Region: Tet_C; cd03711 418127001132 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 418127001133 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 418127001134 NlpC/P60 family; Region: NLPC_P60; cl11438 418127001135 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 418127001136 AAA-like domain; Region: AAA_10; pfam12846 418127001137 TcpE family; Region: TcpE; pfam12648 418127001138 Antirestriction protein (ArdA); Region: ArdA; cl01953 418127001139 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 418127001140 non-specific DNA binding site [nucleotide binding]; other site 418127001141 salt bridge; other site 418127001142 sequence-specific DNA binding site [nucleotide binding]; other site 418127001143 Replication initiation factor; Region: Rep_trans; pfam02486 418127001144 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 418127001145 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 418127001146 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 418127001147 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 418127001148 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 418127001149 UvrD/REP helicase; Region: UvrD-helicase; cl14126 418127001150 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 418127001151 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 418127001152 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 418127001153 putative active site [active] 418127001154 putative metal-binding site [ion binding]; other site 418127001155 Transposase, Mutator family; Region: Transposase_mut; pfam00872 418127001156 MULE transposase domain; Region: MULE; pfam10551 418127001157 PemK-like protein; Region: PemK; cl00995 418127001158 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 418127001159 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 418127001160 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 418127001161 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 418127001162 NADP binding site [chemical binding]; other site 418127001163 superantigen-like protein; Reviewed; Region: PRK13037 418127001164 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 418127001165 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127001166 superantigen-like protein; Reviewed; Region: PRK13041 418127001167 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 418127001168 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127001169 superantigen-like protein; Reviewed; Region: PRK13335 418127001170 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 418127001171 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127001172 superantigen-like protein; Reviewed; Region: PRK13042 418127001173 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 418127001174 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127001175 superantigen-like protein 5; Reviewed; Region: PRK13035 418127001176 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 418127001177 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127001178 superantigen-like protein 7; Reviewed; Region: PRK13346 418127001179 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 418127001180 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127001181 superantigen-like protein; Reviewed; Region: PRK13039 418127001182 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 418127001183 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127001184 superantigen-like protein; Reviewed; Region: PRK13345 418127001185 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 418127001186 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127001187 superantigen-like protein 5; Reviewed; Region: PRK13035 418127001188 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 418127001189 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127001190 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 418127001191 HsdM N-terminal domain; Region: HsdM_N; pfam12161 418127001192 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 418127001193 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 418127001194 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 418127001195 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 418127001196 superantigen-like protein; Reviewed; Region: PRK13036 418127001197 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 418127001198 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127001199 Protein of unknown function, DUF576; Region: DUF576; cl04553 418127001200 Protein of unknown function, DUF576; Region: DUF576; cl04553 418127001201 Protein of unknown function, DUF576; Region: DUF576; cl04553 418127001202 Protein of unknown function, DUF576; Region: DUF576; cl04553 418127001203 Protein of unknown function, DUF576; Region: DUF576; cl04553 418127001204 Protein of unknown function, DUF576; Region: DUF576; cl04553 418127001205 Protein of unknown function, DUF576; Region: DUF576; cl04553 418127001206 Protein of unknown function, DUF576; Region: DUF576; cl04553 418127001207 Protein of unknown function, DUF576; Region: DUF576; cl04553 418127001208 Protein of unknown function, DUF576; Region: DUF576; cl04553 418127001209 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 418127001210 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 418127001211 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 418127001212 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 418127001213 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 418127001214 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 418127001215 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 418127001216 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 418127001217 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 418127001218 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 418127001219 active site 418127001220 Esterase/lipase [General function prediction only]; Region: COG1647 418127001221 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 418127001222 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 418127001223 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 418127001224 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 418127001225 dimer interface [polypeptide binding]; other site 418127001226 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127001227 catalytic residue [active] 418127001228 cystathionine beta-lyase; Provisional; Region: PRK07671 418127001229 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 418127001230 homodimer interface [polypeptide binding]; other site 418127001231 substrate-cofactor binding pocket; other site 418127001232 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127001233 catalytic residue [active] 418127001234 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 418127001235 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein; Region: ABC_MetN_methionine_transporter; cd03258 418127001236 Walker A/P-loop; other site 418127001237 ATP binding site [chemical binding]; other site 418127001238 Q-loop/lid; other site 418127001239 ABC transporter signature motif; other site 418127001240 Walker B; other site 418127001241 D-loop; other site 418127001242 H-loop/switch region; other site 418127001243 NIL domain; Region: NIL; pfam09383 418127001244 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 418127001245 dimer interface [polypeptide binding]; other site 418127001246 conserved gate region; other site 418127001247 ABC-ATPase subunit interface; other site 418127001248 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 418127001249 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 418127001250 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 418127001251 putative peptidoglycan binding site; other site 418127001252 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 418127001253 putative peptidoglycan binding site; other site 418127001254 NlpC/P60 family; Region: NLPC_P60; cl11438 418127001255 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 418127001256 nudix motif; other site 418127001257 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 418127001258 YibE/F-like protein; Region: YibE_F; cl02259 418127001259 YibE/F-like protein; Region: YibE_F; cl02259 418127001260 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127001261 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 418127001262 dimerization interface [polypeptide binding]; other site 418127001263 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 418127001264 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The N-...; Region: GltS; cd00713 418127001265 active site 418127001266 dimer interface [polypeptide binding]; other site 418127001267 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 418127001268 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 418127001269 active site 418127001270 FMN binding site [chemical binding]; other site 418127001271 substrate binding site [chemical binding]; other site 418127001272 3Fe-4S cluster binding site [ion binding]; other site 418127001273 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 418127001274 domain interface; other site 418127001275 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 418127001276 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 418127001277 NAD(P) binding site [chemical binding]; other site 418127001278 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 418127001279 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 418127001280 active site turn [active] 418127001281 phosphorylation site [posttranslational modification] 418127001282 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 418127001283 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 418127001284 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 418127001285 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 418127001286 DNA-binding site [nucleotide binding]; DNA binding site 418127001287 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 418127001288 UTRA domain; Region: UTRA; cl06649 418127001289 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 418127001290 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 418127001291 Coenzyme A binding pocket [chemical binding]; other site 418127001292 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 418127001293 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 418127001294 Walker A motif; other site 418127001295 ATP binding site [chemical binding]; other site 418127001296 Walker B motif; other site 418127001297 arginine finger; other site 418127001298 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 418127001299 recombination protein RecR; Reviewed; Region: recR; PRK00076 418127001300 RecR protein; Region: RecR; pfam02132 418127001301 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 418127001302 putative active site [active] 418127001303 putative metal-binding site [ion binding]; other site 418127001304 tetramer interface [polypeptide binding]; other site 418127001305 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 418127001306 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 418127001307 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 418127001308 catalytic residue [active] 418127001309 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 418127001310 thymidylate kinase; Validated; Region: tmk; PRK00698 418127001311 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 418127001312 TMP-binding site; other site 418127001313 ATP-binding site [chemical binding]; other site 418127001314 Nitrogen regulatory protein P-II; Region: P-II; cl00412 418127001315 DNA polymerase III subunit delta'; Validated; Region: PRK08058 418127001316 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 418127001317 PSP1 C-terminal conserved region; Region: PSP1; cl00770 418127001318 Protein of unknown function (DUF972); Region: DUF972; cl01853 418127001319 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 418127001320 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 418127001321 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 418127001322 Predicted methyltransferases [General function prediction only]; Region: COG0313 418127001323 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 418127001324 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 418127001325 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 418127001326 active site 418127001327 HIGH motif; other site 418127001328 KMSKS motif; other site 418127001329 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 418127001330 tRNA binding surface [nucleotide binding]; other site 418127001331 anticodon binding site; other site 418127001332 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 418127001333 dimer interface [polypeptide binding]; other site 418127001334 putative tRNA-binding site [nucleotide binding]; other site 418127001335 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 418127001336 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 418127001337 active site 418127001338 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 418127001339 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in...; Region: TOPRIM_RNase_M5_like; cd01027 418127001340 putative active site [active] 418127001341 putative metal binding site [ion binding]; other site 418127001342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 418127001343 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 418127001344 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 418127001345 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 418127001346 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 418127001347 pur operon repressor; Provisional; Region: PRK09213 418127001348 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 418127001349 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 418127001350 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 418127001351 homotrimer interaction site [polypeptide binding]; other site 418127001352 putative active site [active] 418127001353 SpoVG; Region: SpoVG; cl00915 418127001354 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 418127001355 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 418127001356 Substrate binding site [chemical binding]; other site 418127001357 Mg++ binding site [ion binding]; other site 418127001358 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 418127001359 active site 418127001360 substrate binding site [chemical binding]; other site 418127001361 CoA binding site [chemical binding]; other site 418127001362 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 418127001363 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 418127001364 Ribosomal_L25_TL5_CTC: Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain. L25 is a single-domain protein, homologous to the N-terminal domain of TL5 and CTC, which each contain two domains. CTC is a known stress protein, and proteins of this...; Region: Ribosomal_L25_TL5_CTC; cd00495 418127001365 5S rRNA interface [nucleotide binding]; other site 418127001366 CTC domain interface; other site 418127001367 L16 interface [polypeptide binding]; other site 418127001368 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 418127001369 putative active site [active] 418127001370 catalytic residue [active] 418127001371 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 418127001372 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 418127001373 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 418127001374 ATP binding site [chemical binding]; other site 418127001375 putative Mg++ binding site [ion binding]; other site 418127001376 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 418127001377 nucleotide binding region [chemical binding]; other site 418127001378 ATP-binding site [chemical binding]; other site 418127001379 TRCF domain; Region: TRCF; pfam03461 418127001380 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 418127001381 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 418127001382 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 418127001383 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 418127001384 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 418127001385 Septum formation initiator; Region: DivIC; cl11433 418127001386 hypothetical protein; Provisional; Region: PRK08582 418127001387 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 418127001388 RNA binding site [nucleotide binding]; other site 418127001389 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 418127001390 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 418127001391 Ligand Binding Site [chemical binding]; other site 418127001392 B3/4 domain; Region: B3_4; cl11458 418127001393 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 418127001394 FtsH Extracellular; Region: FtsH_ext; pfam06480 418127001395 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 418127001396 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 418127001397 Walker A motif; other site 418127001398 ATP binding site [chemical binding]; other site 418127001399 Walker B motif; other site 418127001400 arginine finger; other site 418127001401 Peptidase family M41; Region: Peptidase_M41; pfam01434 418127001402 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 418127001403 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 418127001404 dimerization interface [polypeptide binding]; other site 418127001405 domain crossover interface; other site 418127001406 redox-dependent activation switch; other site 418127001407 cysteine synthases; Region: cysKM; TIGR01136 418127001408 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 418127001409 dimer interface [polypeptide binding]; other site 418127001410 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127001411 catalytic residue [active] 418127001412 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 418127001413 dihydropteroate synthase; Region: DHPS; TIGR01496 418127001414 substrate binding pocket [chemical binding]; other site 418127001415 dimer interface [polypeptide binding]; other site 418127001416 inhibitor binding site; inhibition site 418127001417 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines...; Region: DHNA_DHNTPE; cd00534 418127001418 homooctamer interface [polypeptide binding]; other site 418127001419 active site 418127001420 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 418127001421 catalytic center binding site [active] 418127001422 ATP binding site [chemical binding]; other site 418127001423 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 418127001424 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 418127001425 dimer interface [polypeptide binding]; other site 418127001426 putative anticodon binding site; other site 418127001427 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 418127001428 motif 1; other site 418127001429 active site 418127001430 motif 2; other site 418127001431 motif 3; other site 418127001432 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 418127001433 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 418127001434 DNA-binding site [nucleotide binding]; DNA binding site 418127001435 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 418127001436 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127001437 homodimer interface [polypeptide binding]; other site 418127001438 catalytic residue [active] 418127001439 pyridoxal biosynthesis lyase PdxS; Provisional; Region: PRK04180 418127001440 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 418127001441 active site 418127001442 multimer interface [polypeptide binding]; other site 418127001443 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 418127001444 predicted active site [active] 418127001445 catalytic triad [active] 418127001446 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 418127001447 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 418127001448 Nucleoside recognition; Region: Gate; cl00486 418127001449 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 418127001450 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 418127001451 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 418127001452 UvrB/uvrC motif; Region: UVR; pfam02151 418127001453 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 418127001454 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 418127001455 ADP binding site [chemical binding]; other site 418127001456 phosphagen binding site; other site 418127001457 substrate specificity loop; other site 418127001458 Clp protease ATP binding subunit; Region: clpC; CHL00095 418127001459 Clp amino terminal domain; Region: Clp_N; pfam02861 418127001460 Clp amino terminal domain; Region: Clp_N; pfam02861 418127001461 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 418127001462 Walker A motif; other site 418127001463 ATP binding site [chemical binding]; other site 418127001464 Walker B motif; other site 418127001465 arginine finger; other site 418127001466 UvrB/uvrC motif; Region: UVR; pfam02151 418127001467 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 418127001468 Walker A motif; other site 418127001469 ATP binding site [chemical binding]; other site 418127001470 Walker B motif; other site 418127001471 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 418127001472 DNA repair protein RadA; Provisional; Region: PRK11823 418127001473 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 418127001474 Walker A motif/ATP binding site; other site 418127001475 ATP binding site [chemical binding]; other site 418127001476 Walker B motif; other site 418127001477 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 418127001478 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 418127001479 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 418127001480 putative active site [active] 418127001481 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 418127001482 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 418127001483 active site 418127001484 HIGH motif; other site 418127001485 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 418127001486 active site 418127001487 KMSKS motif; other site 418127001488 serine O-acetyltransferase; Region: cysE; TIGR01172 418127001489 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 418127001490 trimer interface [polypeptide binding]; other site 418127001491 active site 418127001492 substrate binding site [chemical binding]; other site 418127001493 CoA binding site [chemical binding]; other site 418127001494 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 418127001495 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 418127001496 active site 418127001497 HIGH motif; other site 418127001498 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 418127001499 KMSKS motif; other site 418127001500 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 418127001501 tRNA binding surface [nucleotide binding]; other site 418127001502 anticodon binding site; other site 418127001503 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cl00258 418127001504 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 418127001505 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 418127001506 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 418127001507 YacP-like NYN domain; Region: NYN_YacP; cl01491 418127001508 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 418127001509 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 418127001510 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 418127001511 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 418127001512 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 418127001513 putative homodimer interface [polypeptide binding]; other site 418127001514 similar to hypothetical protein 418127001515 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 418127001516 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 418127001517 23S rRNA interface [nucleotide binding]; other site 418127001518 L7/L12 interface [polypeptide binding]; other site 418127001519 putative thiostrepton binding site; other site 418127001520 L25 interface [polypeptide binding]; other site 418127001521 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 418127001522 mRNA/rRNA interface [nucleotide binding]; other site 418127001523 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 418127001524 23S rRNA interface [nucleotide binding]; other site 418127001525 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 418127001526 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 418127001527 peripheral dimer interface [polypeptide binding]; other site 418127001528 core dimer interface [polypeptide binding]; other site 418127001529 L10 interface [polypeptide binding]; other site 418127001530 L11 interface [polypeptide binding]; other site 418127001531 putative EF-Tu interaction site [polypeptide binding]; other site 418127001532 putative EF-G interaction site [polypeptide binding]; other site 418127001533 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 418127001534 S-adenosylmethionine binding site [chemical binding]; other site 418127001535 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 418127001536 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591 418127001537 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 418127001538 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 418127001539 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 418127001540 RPB12 interaction site [polypeptide binding]; other site 418127001541 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 418127001542 RPB10 interaction site [polypeptide binding]; other site 418127001543 RPB1 interaction site [polypeptide binding]; other site 418127001544 RPB11 interaction site [polypeptide binding]; other site 418127001545 RPB3 interaction site [polypeptide binding]; other site 418127001546 RPB12 interaction site [polypeptide binding]; other site 418127001547 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 418127001548 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 418127001549 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 418127001550 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 418127001551 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 418127001552 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 418127001553 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 418127001554 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 418127001555 G-loop; other site 418127001556 DNA binding site [nucleotide binding] 418127001557 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 418127001558 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 418127001559 S17 interaction site [polypeptide binding]; other site 418127001560 S8 interaction site; other site 418127001561 16S rRNA interaction site [nucleotide binding]; other site 418127001562 streptomycin interaction site [chemical binding]; other site 418127001563 23S rRNA interaction site [nucleotide binding]; other site 418127001564 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 418127001565 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 418127001566 elongation factor G; Reviewed; Region: PRK00007 418127001567 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 418127001568 G1 box; other site 418127001569 putative GEF interaction site [polypeptide binding]; other site 418127001570 GTP/Mg2+ binding site [chemical binding]; other site 418127001571 Switch I region; other site 418127001572 G2 box; other site 418127001573 G3 box; other site 418127001574 Switch II region; other site 418127001575 G4 box; other site 418127001576 G5 box; other site 418127001577 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 418127001578 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 418127001579 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 418127001580 elongation factor Tu; Reviewed; Region: PRK00049 418127001581 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 418127001582 G1 box; other site 418127001583 GEF interaction site [polypeptide binding]; other site 418127001584 GTP/Mg2+ binding site [chemical binding]; other site 418127001585 Switch I region; other site 418127001586 G2 box; other site 418127001587 G3 box; other site 418127001588 Switch II region; other site 418127001589 G4 box; other site 418127001590 G5 box; other site 418127001591 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 418127001592 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 418127001593 Antibiotic Binding Site [chemical binding]; other site 418127001594 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 418127001595 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 418127001596 metal binding site [ion binding]; metal-binding site 418127001597 dimer interface [polypeptide binding]; other site 418127001598 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 418127001599 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-...; Region: KBL_like; cd06454 418127001600 substrate-cofactor binding pocket; other site 418127001601 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127001602 catalytic residue [active] 418127001603 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 418127001604 dimer interface [polypeptide binding]; other site 418127001605 metal binding site [ion binding]; metal-binding site 418127001606 potential oxyanion hole; other site 418127001607 potential catalytic triad [active] 418127001608 conserved cys residue [active] 418127001609 ribulokinase; Provisional; Region: PRK04123 418127001610 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 418127001611 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 418127001612 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 418127001613 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127001614 NAD(P) binding site [chemical binding]; other site 418127001615 active site 418127001616 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 418127001617 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557 418127001618 homodimer interface [polypeptide binding]; other site 418127001619 substrate-cofactor binding pocket; other site 418127001620 catalytic residue [active] 418127001621 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 418127001622 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 418127001623 motif II; other site 418127001624 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 418127001625 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7...; Region: dNK; cd01673 418127001626 Substrate-binding site [chemical binding]; other site 418127001627 Substrate specificity [chemical binding]; other site 418127001628 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 418127001629 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7...; Region: dNK; cd01673 418127001630 Substrate-binding site [chemical binding]; other site 418127001631 Substrate specificity [chemical binding]; other site 418127001632 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 418127001633 nucleoside/Zn binding site; other site 418127001634 dimer interface [polypeptide binding]; other site 418127001635 catalytic motif [active] 418127001636 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 418127001637 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 418127001638 active site 418127001639 motif I; other site 418127001640 motif II; other site 418127001641 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 418127001642 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 418127001643 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 418127001644 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 418127001645 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 418127001646 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 418127001647 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 418127001648 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 418127001649 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 418127001650 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 418127001651 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 418127001652 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 418127001653 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 418127001654 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 418127001655 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 418127001656 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 418127001657 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 418127001658 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 418127001659 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 418127001660 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 418127001661 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 418127001662 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 418127001663 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 418127001664 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 418127001665 Uncharacterized ACR, COG1469; Region: DUF198; cl00642 418127001666 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 418127001667 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 418127001668 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination...; Region: GlcN6P_deaminase; cd01399 418127001669 active site 418127001670 trimer interface [polypeptide binding]; other site 418127001671 allosteric site; other site 418127001672 active site lid [active] 418127001673 hexamer (dimer of trimers) interface [polypeptide binding]; other site 418127001674 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 418127001675 active site 418127001676 dimer interface [polypeptide binding]; other site 418127001677 magnesium binding site [ion binding]; other site 418127001678 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 418127001679 tetramer interface [polypeptide binding]; other site 418127001680 active site 418127001681 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 418127001682 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 418127001683 motif II; other site 418127001684 proline/glycine betaine transporter; Provisional; Region: PRK10642 418127001685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127001686 putative substrate translocation pore; other site 418127001687 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 418127001688 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 418127001689 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 418127001690 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 418127001691 dimer interface [polypeptide binding]; other site 418127001692 active site 418127001693 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427 418127001694 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 418127001695 dimer interface [polypeptide binding]; other site 418127001696 substrate binding site [chemical binding]; other site 418127001697 ATP binding site [chemical binding]; other site 418127001698 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 418127001699 Protein of unknown function (DUF423); Region: DUF423; cl01008 418127001700 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 418127001701 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 418127001702 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 418127001703 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 418127001704 Chlorite dismutase; Region: Chlor_dismutase; cl01280 418127001705 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 418127001706 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 418127001707 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 418127001708 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 418127001709 mevalonate kinase; Region: mevalon_kin; TIGR00549 418127001710 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 418127001711 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 418127001712 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 418127001713 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 418127001714 Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 418127001715 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 418127001716 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 418127001717 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 418127001718 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 418127001719 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 418127001720 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 418127001721 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 418127001722 Predicted transcriptional regulator [Transcription]; Region: COG1959 418127001723 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127001724 Bacillus transposase protein; Region: Transposase_30; pfam04740 418127001725 Protein of unknown function (DUF443); Region: DUF443; cl04467 418127001726 Protein of unknown function (DUF443); Region: DUF443; cl04467 418127001727 Protein of unknown function (DUF443); Region: DUF443; cl04467 418127001728 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 418127001729 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 418127001730 active site 418127001731 catalytic tetrad [active] 418127001732 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 418127001733 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 418127001734 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 418127001735 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 418127001736 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 418127001737 Zn2+ binding site [ion binding]; other site 418127001738 Mg2+ binding site [ion binding]; other site 418127001739 YwhD family; Region: YwhD; pfam08741 418127001740 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 418127001741 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 418127001742 NAD binding site [chemical binding]; other site 418127001743 substrate binding site [chemical binding]; other site 418127001744 catalytic Zn binding site [ion binding]; other site 418127001745 tetramer interface [polypeptide binding]; other site 418127001746 structural Zn binding site [ion binding]; other site 418127001747 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 418127001748 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 418127001749 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 418127001750 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 418127001751 active site 418127001752 HIGH motif; other site 418127001753 KMSK motif region; other site 418127001754 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 418127001755 tRNA binding surface [nucleotide binding]; other site 418127001756 anticodon binding site; other site 418127001757 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 418127001758 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 418127001759 minor groove reading motif; other site 418127001760 helix-hairpin-helix signature motif; other site 418127001761 substrate binding pocket [chemical binding]; other site 418127001762 active site 418127001763 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 418127001764 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 418127001765 putative binding site residues; other site 418127001766 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 418127001767 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 418127001768 ABC-ATPase subunit interface; other site 418127001769 dimer interface [polypeptide binding]; other site 418127001770 putative PBP binding regions; other site 418127001771 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 418127001772 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 418127001773 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 418127001774 motif II; other site 418127001775 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 418127001776 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 418127001777 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 418127001778 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 418127001779 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127001780 Protein of unknown function, DUF606; Region: DUF606; cl01273 418127001781 Protein of unknown function, DUF606; Region: DUF606; cl01273 418127001782 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 418127001783 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 418127001784 Phage integrase family; Region: Phage_integrase; pfam00589 418127001785 DNA binding site [nucleotide binding] 418127001786 Int/Topo IB signature motif; other site 418127001787 active site 418127001788 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646 418127001789 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 418127001790 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 418127001791 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 418127001792 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 418127001793 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 418127001794 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 418127001795 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 418127001796 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 418127001797 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 418127001798 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 418127001799 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 418127001800 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 418127001801 Transposase; Region: DDE_Tnp_ISL3; pfam01610 418127001802 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 418127001803 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 418127001804 metal binding site [ion binding]; metal-binding site 418127001805 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 418127001806 ABC-ATPase subunit interface; other site 418127001807 dimer interface [polypeptide binding]; other site 418127001808 putative PBP binding regions; other site 418127001809 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 418127001810 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 418127001811 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 418127001812 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127001813 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 418127001814 FeoA domain; Region: FeoA; cl00838 418127001815 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 418127001816 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 418127001817 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides...; Region: ABC_KpsT_Wzt; cd03220 418127001818 Walker A/P-loop; other site 418127001819 ATP binding site [chemical binding]; other site 418127001820 Q-loop/lid; other site 418127001821 ABC transporter signature motif; other site 418127001822 Walker B; other site 418127001823 D-loop; other site 418127001824 H-loop/switch region; other site 418127001825 ABC-2 type transporter; Region: ABC2_membrane; cl11417 418127001826 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 418127001827 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 418127001828 active site 418127001829 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 418127001830 active site 418127001831 nucleotide binding site [chemical binding]; other site 418127001832 HIGH motif; other site 418127001833 KMSKS motif; other site 418127001834 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 418127001835 Beta-lactamase; Region: Beta-lactamase; cl01009 418127001836 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 418127001837 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 418127001838 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 418127001839 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 418127001840 Walker A/P-loop; other site 418127001841 ATP binding site [chemical binding]; other site 418127001842 Q-loop/lid; other site 418127001843 ABC transporter signature motif; other site 418127001844 Walker B; other site 418127001845 D-loop; other site 418127001846 H-loop/switch region; other site 418127001847 similar to hypothetical protein 418127001848 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 418127001849 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 418127001850 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 418127001851 Uncharacterized conserved protein [Function unknown]; Region: COG1284 418127001852 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 418127001853 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 418127001854 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 418127001855 Walker A/P-loop; other site 418127001856 ATP binding site [chemical binding]; other site 418127001857 Q-loop/lid; other site 418127001858 ABC transporter signature motif; other site 418127001859 Walker B; other site 418127001860 D-loop; other site 418127001861 H-loop/switch region; other site 418127001862 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 418127001863 ABC-ATPase subunit interface; other site 418127001864 dimer interface [polypeptide binding]; other site 418127001865 putative PBP binding regions; other site 418127001866 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 418127001867 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 418127001868 ABC-ATPase subunit interface; other site 418127001869 dimer interface [polypeptide binding]; other site 418127001870 putative PBP binding regions; other site 418127001871 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 418127001872 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 418127001873 DAK2 domain; Region: Dak2; cl03685 418127001874 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cl00025 418127001875 Uncharacterized membrane protein [Function unknown]; Region: COG3949 418127001876 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 418127001877 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 418127001878 substrate binding pocket [chemical binding]; other site 418127001879 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 418127001880 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 418127001881 Coenzyme A binding pocket [chemical binding]; other site 418127001882 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 418127001883 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127001884 NAD(P) binding site [chemical binding]; other site 418127001885 active site 418127001886 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 418127001887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 418127001888 active site 418127001889 phosphorylation site [posttranslational modification] 418127001890 intermolecular recognition site; other site 418127001891 dimerization interface [polypeptide binding]; other site 418127001892 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 418127001893 DNA binding site [nucleotide binding] 418127001894 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 418127001895 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 418127001896 ATP binding site [chemical binding]; other site 418127001897 Mg2+ binding site [ion binding]; other site 418127001898 G-X-G motif; other site 418127001899 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 418127001900 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 418127001901 Walker A/P-loop; other site 418127001902 ATP binding site [chemical binding]; other site 418127001903 Q-loop/lid; other site 418127001904 ABC transporter signature motif; other site 418127001905 Walker B; other site 418127001906 D-loop; other site 418127001907 H-loop/switch region; other site 418127001908 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 418127001909 Phosphate transporter family; Region: PHO4; cl00396 418127001910 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 418127001911 putative peptidoglycan binding site; other site 418127001912 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 418127001913 putative peptidoglycan binding site; other site 418127001914 NlpC/P60 family; Region: NLPC_P60; cl11438 418127001915 BAX inhibitor (BI)-1 like protein family. Mammalian members of this family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well characterized oncogene, or...; Region: BI-1-like; cl00473 418127001916 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 418127001917 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127001918 Domain of unknown function DUF28; Region: DUF28; cl00361 418127001919 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 418127001920 Protein of unknown function (DUF402); Region: DUF402; cl00979 418127001921 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 418127001922 dimerization interface [polypeptide binding]; other site 418127001923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127001924 sugar efflux transporter; Region: 2A0120; TIGR00899 418127001925 putative substrate translocation pore; other site 418127001926 Protein of unknown function (DUF456); Region: DUF456; cl01069 418127001927 Serine incorporator (Serinc); Region: Serinc; pfam03348 418127001928 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 418127001929 Coenzyme A binding pocket [chemical binding]; other site 418127001930 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 418127001931 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 418127001932 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 418127001933 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 418127001934 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 418127001935 Bacitracin resistance protein BacA; Region: BacA; cl00858 418127001936 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 418127001937 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 418127001938 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with...; Region: ABCC_MRP_Like; cd03228 418127001939 Walker A/P-loop; other site 418127001940 ATP binding site [chemical binding]; other site 418127001941 Q-loop/lid; other site 418127001942 ABC transporter signature motif; other site 418127001943 Walker B; other site 418127001944 D-loop; other site 418127001945 H-loop/switch region; other site 418127001946 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 418127001947 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 418127001948 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with...; Region: ABCC_MRP_Like; cd03228 418127001949 Walker A/P-loop; other site 418127001950 ATP binding site [chemical binding]; other site 418127001951 Q-loop/lid; other site 418127001952 ABC transporter signature motif; other site 418127001953 Walker B; other site 418127001954 D-loop; other site 418127001955 H-loop/switch region; other site 418127001956 Transcriptional regulators [Transcription]; Region: MarR; COG1846 418127001957 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127001958 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 418127001959 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 418127001960 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 418127001961 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 418127001962 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 418127001963 active site 418127001964 catalytic tetrad [active] 418127001965 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 418127001966 transmembrane helices; other site 418127001967 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 418127001968 DNA photolyase; Region: DNA_photolyase; pfam00875 418127001969 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 418127001970 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 418127001971 Domain of unknown function (DUF296); Region: DUF296; cl00720 418127001972 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127001973 putative substrate translocation pore; other site 418127001974 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS); Region: YbaK_deacylase; cd00002 418127001975 putative deacylase active site [active] 418127001976 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 418127001977 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127001978 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 418127001979 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 418127001980 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 418127001981 putative substrate binding site [chemical binding]; other site 418127001982 putative ATP binding site [chemical binding]; other site 418127001983 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 418127001984 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 418127001985 active site 418127001986 phosphorylation site [posttranslational modification] 418127001987 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 418127001988 P-loop; other site 418127001989 active site 418127001990 phosphorylation site [posttranslational modification] 418127001991 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 418127001992 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 418127001993 active site 418127001994 dimer interface [polypeptide binding]; other site 418127001995 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 418127001996 Domain of unknown function DUF21; Region: DUF21; pfam01595 418127001997 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 418127001998 Transporter associated domain; Region: CorC_HlyC; pfam03471 418127001999 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 418127002000 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 418127002001 active site 418127002002 catalytic tetrad [active] 418127002003 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 418127002004 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 418127002005 Ligand binding site [chemical binding]; other site 418127002006 Putative Catalytic site [active] 418127002007 DXD motif; other site 418127002008 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 418127002009 dimer interface [polypeptide binding]; other site 418127002010 phosphorylation site [posttranslational modification] 418127002011 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 418127002012 ATP binding site [chemical binding]; other site 418127002013 Mg2+ binding site [ion binding]; other site 418127002014 G-X-G motif; other site 418127002015 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 418127002016 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 418127002017 active site 418127002018 phosphorylation site [posttranslational modification] 418127002019 intermolecular recognition site; other site 418127002020 dimerization interface [polypeptide binding]; other site 418127002021 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 418127002022 DNA binding site [nucleotide binding] 418127002023 Electron transfer DM13; Region: DM13; cl02735 418127002024 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 418127002025 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 418127002026 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 418127002027 active site 418127002028 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 418127002029 Ligand Binding Site [chemical binding]; other site 418127002030 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 418127002031 Glutamine amidotransferase class-I; Region: GATase; pfam00117 418127002032 glutamine binding [chemical binding]; other site 418127002033 catalytic triad [active] 418127002034 aminodeoxychorismate synthase; Provisional; Region: PRK07508 418127002035 chorismate binding enzyme; Region: Chorismate_bind; cl10555 418127002036 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 418127002037 substrate-cofactor binding pocket; other site 418127002038 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127002039 catalytic residue [active] 418127002040 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 418127002041 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 418127002042 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 418127002043 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 418127002044 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 418127002045 Sulfatase; Region: Sulfatase; cl10460 418127002046 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 418127002047 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 418127002048 Walker A/P-loop; other site 418127002049 ATP binding site [chemical binding]; other site 418127002050 Q-loop/lid; other site 418127002051 ABC transporter signature motif; other site 418127002052 Walker B; other site 418127002053 D-loop; other site 418127002054 H-loop/switch region; other site 418127002055 ABC transporter; Region: ABC_tran_2; pfam12848 418127002056 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 418127002057 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 418127002058 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 418127002059 ATP binding site [chemical binding]; other site 418127002060 putative Mg++ binding site [ion binding]; other site 418127002061 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 418127002062 nucleotide binding region [chemical binding]; other site 418127002063 ATP-binding site [chemical binding]; other site 418127002064 RQC domain; Region: RQC; pfam09382 418127002065 HRDC domain; Region: HRDC; cl02578 418127002066 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 418127002067 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family...; Region: ABC_OpuCA_Osmoprotection; cd03295 418127002068 Walker A/P-loop; other site 418127002069 ATP binding site [chemical binding]; other site 418127002070 Q-loop/lid; other site 418127002071 ABC transporter signature motif; other site 418127002072 Walker B; other site 418127002073 D-loop; other site 418127002074 H-loop/switch region; other site 418127002075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 418127002076 dimer interface [polypeptide binding]; other site 418127002077 conserved gate region; other site 418127002078 ABC-ATPase subunit interface; other site 418127002079 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 418127002080 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 418127002081 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 418127002082 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 418127002083 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127002084 homodimer interface [polypeptide binding]; other site 418127002085 catalytic residue [active] 418127002086 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl01869 418127002087 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 418127002088 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 418127002089 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 418127002090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127002091 putative substrate translocation pore; other site 418127002092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 418127002093 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 418127002094 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 418127002095 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 418127002096 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 418127002097 Class I ribonucleotide reductase; Region: RNR_I; cd01679 418127002098 active site 418127002099 dimer interface [polypeptide binding]; other site 418127002100 catalytic residues [active] 418127002101 effector binding site; other site 418127002102 R2 peptide binding site; other site 418127002103 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 418127002104 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 418127002105 dimer interface [polypeptide binding]; other site 418127002106 putative radical transfer pathway; other site 418127002107 diiron center [ion binding]; other site 418127002108 tyrosyl radical; other site 418127002109 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 418127002110 ABC-ATPase subunit interface; other site 418127002111 dimer interface [polypeptide binding]; other site 418127002112 putative PBP binding regions; other site 418127002113 ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism]; Region: CeuC; COG4605 418127002114 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 418127002115 ABC-ATPase subunit interface; other site 418127002116 dimer interface [polypeptide binding]; other site 418127002117 putative PBP binding regions; other site 418127002118 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 418127002119 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 418127002120 Walker A/P-loop; other site 418127002121 ATP binding site [chemical binding]; other site 418127002122 Q-loop/lid; other site 418127002123 ABC transporter signature motif; other site 418127002124 Walker B; other site 418127002125 D-loop; other site 418127002126 H-loop/switch region; other site 418127002127 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 418127002128 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 418127002129 putative ligand binding residues [chemical binding]; other site 418127002130 CHY zinc finger; Region: zf-CHY; cl14900 418127002131 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906 418127002132 FAD binding domain; Region: FAD_binding_4; pfam01565 418127002133 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 418127002134 Uncharacterised protein family (UPF0157); Region: UPF0157; cl00987 418127002135 Protein of unknown function (DUF2847); Region: DUF2847; cl12579 418127002136 Glycerate kinase family; Region: Gly_kinase; cl00841 418127002137 peptidase T; Region: peptidase-T; TIGR01882 418127002138 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 418127002139 metal binding site [ion binding]; metal-binding site 418127002140 dimer interface [polypeptide binding]; other site 418127002141 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 418127002142 Uncharacterized conserved protein [Function unknown]; Region: COG2966 418127002143 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 418127002144 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 418127002145 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 418127002146 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 418127002147 metal binding site [ion binding]; metal-binding site 418127002148 active site 418127002149 I-site; other site 418127002150 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 418127002151 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 418127002152 Mg++ binding site [ion binding]; other site 418127002153 putative catalytic motif [active] 418127002154 substrate binding site [chemical binding]; other site 418127002155 Uncharacterized conserved protein [Function unknown]; Region: COG1739 418127002156 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 418127002157 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 418127002158 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 418127002159 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 418127002160 putative Mg++ binding site [ion binding]; other site 418127002161 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 418127002162 nucleotide binding region [chemical binding]; other site 418127002163 ATP-binding site [chemical binding]; other site 418127002164 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 418127002165 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 418127002166 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 418127002167 30S subunit binding site; other site 418127002168 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 418127002169 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 418127002170 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 418127002171 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 418127002172 SEC-C motif; Region: SEC-C; cl12132 418127002173 peptide chain release factor 2; Provisional; Region: PRK06746 418127002174 RF-1 domain; Region: RF-1; cl02875 418127002175 RF-1 domain; Region: RF-1; cl02875 418127002176 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 418127002177 NlpC/P60 family; Region: NLPC_P60; cl11438 418127002178 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 418127002179 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 418127002180 excinuclease ABC subunit B; Provisional; Region: PRK05298 418127002181 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 418127002182 ATP binding site [chemical binding]; other site 418127002183 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 418127002184 nucleotide binding region [chemical binding]; other site 418127002185 ATP-binding site [chemical binding]; other site 418127002186 Ultra-violet resistance protein B; Region: UvrB; pfam12344 418127002187 UvrB/uvrC motif; Region: UVR; pfam02151 418127002188 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 418127002189 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 418127002190 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 418127002191 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 418127002192 HPr kinase/phosphorylase; Provisional; Region: PRK05428 418127002193 DRTGG domain; Region: DRTGG; cl12147 418127002194 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-...; Region: HprK_C; cd01918 418127002195 Hpr binding site; other site 418127002196 active site 418127002197 homohexamer subunit interaction site [polypeptide binding]; other site 418127002198 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 418127002199 putative acyl transferase; Provisional; Region: PRK10191 418127002200 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 418127002201 putative trimer interface [polypeptide binding]; other site 418127002202 putative CoA binding site [chemical binding]; other site 418127002203 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 418127002204 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 418127002205 TPR motif; other site 418127002206 binding surface 418127002207 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 418127002208 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 418127002209 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 418127002210 P-loop ATPase protein family; Region: ATP_bind_2; cl10035 418127002211 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 418127002212 Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933 418127002213 phosphate binding site [ion binding]; other site 418127002214 dimer interface [polypeptide binding]; other site 418127002215 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 418127002216 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 418127002217 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 418127002218 oligomer interface [polypeptide binding]; other site 418127002219 active site residues [active] 418127002220 TIGR01777 family protein; Region: yfcH 418127002221 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127002222 NAD(P) binding site [chemical binding]; other site 418127002223 active site 418127002224 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 418127002225 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 418127002226 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127002227 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 418127002228 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 418127002229 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 418127002230 substrate binding site [chemical binding]; other site 418127002231 hinge regions; other site 418127002232 ADP binding site [chemical binding]; other site 418127002233 catalytic site [active] 418127002234 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 418127002235 substrate binding site [chemical binding]; other site 418127002236 dimer interface [polypeptide binding]; other site 418127002237 catalytic triad [active] 418127002238 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 418127002239 Sulfatase; Region: Sulfatase; cl10460 418127002240 enolase; Provisional; Region: eno; PRK00077 418127002241 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 418127002242 dimer interface [polypeptide binding]; other site 418127002243 metal binding site [ion binding]; metal-binding site 418127002244 substrate binding pocket [chemical binding]; other site 418127002245 Preprotein translocase SecG subunit; Region: SecG; cl09123 418127002246 Esterase/lipase [General function prediction only]; Region: COG1647 418127002247 ribonuclease R; Region: RNase_R; TIGR02063 418127002248 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 418127002249 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 418127002250 RNB domain; Region: RNB; pfam00773 418127002251 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an...; Region: S1_RNase_R; cd04471 418127002252 RNA binding site [nucleotide binding]; other site 418127002253 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 418127002254 SmpB-tmRNA interface; other site 418127002255 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 418127002256 Phage integrase family; Region: Phage_integrase; pfam00589 418127002257 Int/Topo IB signature motif; other site 418127002258 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 418127002259 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 418127002260 Protein of unknown function (DUF1474); Region: DUF1474; pfam07342 418127002261 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 418127002262 Virulence-associated protein E; Region: VirE; pfam05272 418127002263 hydrolase, hydrolyzing O-glycosyl compounds; Region: PLN02219; cl14104 418127002264 Coat F domain; Region: Coat_F; cl02368 418127002265 Terminase small subunit; Region: Terminase_2; cl01513 418127002266 Abi-like protein; Region: Abi_2; cl01988 418127002267 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: FeuA; cd01138 418127002268 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 418127002269 putative ligand binding residues [chemical binding]; other site 418127002270 Leucine carboxyl methyltransferase; Region: LCM; cl01306 418127002271 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 418127002272 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 418127002273 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 418127002274 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 418127002275 Staphylococcal nuclease homologues; Region: SNc; smart00318 418127002276 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 418127002277 Catalytic site; other site 418127002278 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 418127002279 DNA-binding site [nucleotide binding]; DNA binding site 418127002280 RNA-binding motif; other site 418127002281 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 418127002282 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 418127002283 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 418127002284 catalytic core [active] 418127002285 LysE type translocator; Region: LysE; cl00565 418127002286 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 418127002287 similar to hypothetical protein 418127002288 OsmC-like protein; Region: OsmC; cl00767 418127002289 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 418127002290 active site 418127002291 3-dehydroquinate dehydratase, type I; Region: aroD; TIGR01093 418127002292 catalytic residue [active] 418127002293 dimer interface [polypeptide binding]; other site 418127002294 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a beta-...; Region: Arsenite_oxidase; cd02135 418127002295 putative FMN binding site [chemical binding]; other site 418127002296 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 418127002297 catalytic residues [active] 418127002298 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 418127002299 putative ArsC-like catalytic residues; other site 418127002300 putative TRX-like catalytic residues [active] 418127002301 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 418127002302 lipoyl attachment site [posttranslational modification]; other site 418127002303 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 418127002304 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in...; Region: TOPRIM_RNase_M5_like; cd01027 418127002305 putative active site [active] 418127002306 putative metal binding site [ion binding]; other site 418127002307 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 418127002308 catalytic residues [active] 418127002309 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 418127002310 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein; Region: ABC_MetN_methionine_transporter; cd03258 418127002311 Walker A/P-loop; other site 418127002312 ATP binding site [chemical binding]; other site 418127002313 Q-loop/lid; other site 418127002314 ABC transporter signature motif; other site 418127002315 Walker B; other site 418127002316 D-loop; other site 418127002317 H-loop/switch region; other site 418127002318 NIL domain; Region: NIL; pfam09383 418127002319 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 418127002320 dimer interface [polypeptide binding]; other site 418127002321 conserved gate region; other site 418127002322 ABC-ATPase subunit interface; other site 418127002323 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 418127002324 CsbD-like; Region: CsbD; cl01272 418127002325 Domain of unknown function (DUF368); Region: DUF368; cl00893 418127002326 FeS assembly ATPase SufC; Region: sufC; TIGR01978 418127002327 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 418127002328 Walker A/P-loop; other site 418127002329 ATP binding site [chemical binding]; other site 418127002330 Q-loop/lid; other site 418127002331 ABC transporter signature motif; other site 418127002332 Walker B; other site 418127002333 D-loop; other site 418127002334 H-loop/switch region; other site 418127002335 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 418127002336 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 418127002337 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 418127002338 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 418127002339 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 418127002340 catalytic residue [active] 418127002341 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 418127002342 trimerization site [polypeptide binding]; other site 418127002343 active site 418127002344 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 418127002345 FeS assembly protein SufB; Region: sufB; TIGR01980 418127002346 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 418127002347 Int/Topo IB signature motif; other site 418127002348 Domain of unknown function (DUF955); Region: DUF955; cl01076 418127002349 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 418127002350 non-specific DNA binding site [nucleotide binding]; other site 418127002351 salt bridge; other site 418127002352 sequence-specific DNA binding site [nucleotide binding]; other site 418127002353 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 418127002354 non-specific DNA binding site [nucleotide binding]; other site 418127002355 salt bridge; other site 418127002356 sequence-specific DNA binding site [nucleotide binding]; other site 418127002357 BRO family, N-terminal domain; Region: Bro-N; pfam02498 418127002358 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 418127002359 Hypothetical protein of unknown function (DUF2482); Region: DUF2482; pfam10655 418127002360 Hypothetical protein of unknown function (DUF2483); Region: DUF2483; pfam10656 418127002361 Protein of unknown function (DUF1071); Region: DUF1071; pfam06378 418127002362 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 418127002363 dimer interface [polypeptide binding]; other site 418127002364 ssDNA binding site [nucleotide binding]; other site 418127002365 tetramer (dimer of dimers) interface [polypeptide binding]; other site 418127002366 NUMOD4 motif; Region: NUMOD4; pfam07463 418127002367 Protein of unknown function (DUF968); Region: DUF968; pfam06147 418127002368 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 418127002369 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 418127002370 Walker A motif; other site 418127002371 ATP binding site [chemical binding]; other site 418127002372 Walker B motif; other site 418127002373 arginine finger; other site 418127002374 Protein of unknown function (DUF3269); Region: DUF3269; pfam11673 418127002375 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 418127002376 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 418127002377 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 418127002378 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 418127002379 dUTPase; Region: dUTPase_2; pfam08761 418127002380 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 418127002381 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 418127002382 Transcriptional activator RinB; Region: RinB; pfam06116 418127002383 similar to hypothetical protein 418127002384 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 418127002385 Terminase small subunit; Region: Terminase_2; cl01513 418127002386 Phage terminase large subunit; Region: Terminase_3; cl12054 418127002387 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 418127002388 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 418127002389 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 418127002390 Phage capsid family; Region: Phage_capsid; pfam05065 418127002391 Phage capsid family; Region: Phage_capsid; pfam05065 418127002392 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 418127002393 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 418127002394 Phage major tail protein 2; Region: Phage_tail_2; cl11463 418127002395 Phage protein; Region: DUF3647; cl10335 418127002396 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 418127002397 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 418127002398 Phage-related protein [Function unknown]; Region: COG5412 418127002399 membrane protein P6; Region: PHA01399 418127002400 Phage-related protein [Function unknown]; Region: COG5412 418127002401 Phage tail protein; Region: Sipho_tail; cl11462 418127002402 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 418127002403 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 418127002404 active site 418127002405 catalytic triad [active] 418127002406 oxyanion hole [active] 418127002407 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 418127002408 cell division protein MukB; Provisional; Region: mukB; PRK04863 418127002409 Protein of unknown function (DUF2977); Region: DUF2977; pfam11192 418127002410 Phage uncharacterised protein (Phage_XkdX); Region: Phage_XkdX; cl09900 418127002411 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 418127002412 NlpC/P60 family; Region: NLPC_P60; cl11438 418127002413 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 418127002414 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 418127002415 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 418127002416 Phage tail repeat like; Region: PTR; pfam12789 418127002417 Bacteriophage holin; Region: Phage_holin_1; cl02344 418127002418 NlpC/P60 family; Region: NLPC_P60; cl11438 418127002419 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 418127002420 amidase catalytic site [active] 418127002421 Zn binding residues [ion binding]; other site 418127002422 substrate binding site [chemical binding]; other site 418127002423 Bacterial SH3 domain; Region: SH3_5; pfam08460 418127002424 Uncharacterized phage-associated protein [Function unknown]; Region: GepA; COG3600 418127002425 Domain of unknown function DUF21; Region: DUF21; pfam01595 418127002426 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 418127002427 Nitronate monooxygenase; Region: NMO; pfam03060 418127002428 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 418127002429 FMN binding site [chemical binding]; other site 418127002430 substrate binding site [chemical binding]; other site 418127002431 putative catalytic residue [active] 418127002432 Protein of unknown function DUF72; Region: DUF72; cl00777 418127002433 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 418127002434 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 418127002435 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 418127002436 active site 418127002437 metal binding site [ion binding]; metal-binding site 418127002438 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 418127002439 lipoyl synthase; Provisional; Region: PRK05481 418127002440 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 418127002441 FeS/SAM binding site; other site 418127002442 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 418127002443 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 418127002444 Transposase; Region: DDE_Tnp_ISL3; pfam01610 418127002445 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 418127002446 Protein of unknown function DUF86; Region: DUF86; cl01031 418127002447 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 418127002448 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 418127002449 active site 418127002450 motif I; other site 418127002451 motif II; other site 418127002452 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 418127002453 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 418127002454 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127002455 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 418127002456 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 418127002457 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 418127002458 MBOAT family; Region: MBOAT; cl00738 418127002459 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087; cl07963 418127002460 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 418127002461 DltD N-terminal region; Region: DltD_N; pfam04915 418127002462 DltD central region; Region: DltD_M; pfam04918 418127002463 DltD C-terminal region; Region: DltD_C; pfam04914 418127002464 NifU-like domain; Region: NifU; cl00484 418127002465 Protein of unknown function (DUF1462); Region: DUF1462; cl11552 418127002466 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 418127002467 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 418127002468 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 418127002469 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 418127002470 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 418127002471 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 418127002472 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 418127002473 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 418127002474 interface (dimer of trimers) [polypeptide binding]; other site 418127002475 Substrate-binding/catalytic site; other site 418127002476 Zn-binding sites [ion binding]; other site 418127002477 Predicted permease [General function prediction only]; Region: COG2056 418127002478 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 418127002479 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 418127002480 CoenzymeA binding site [chemical binding]; other site 418127002481 subunit interaction site [polypeptide binding]; other site 418127002482 PHB binding site; other site 418127002483 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 418127002484 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 418127002485 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 418127002486 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 418127002487 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 418127002488 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 418127002489 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 418127002490 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 418127002491 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 418127002492 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 418127002493 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 418127002494 Kinase associated protein B; Region: KapB; pfam08810 418127002495 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 418127002496 active site 418127002497 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 418127002498 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 418127002499 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 418127002500 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 418127002501 putative active site [active] 418127002502 putative FMN binding site [chemical binding]; other site 418127002503 putative substrate binding site [chemical binding]; other site 418127002504 putative catalytic residue [active] 418127002505 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 418127002506 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 418127002507 inhibitor-cofactor binding pocket; inhibition site 418127002508 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127002509 catalytic residue [active] 418127002510 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 418127002511 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 418127002512 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 418127002513 NAD(P) binding site [chemical binding]; other site 418127002514 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 418127002515 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 418127002516 active site 418127002517 catalytic site [active] 418127002518 metal binding site [ion binding]; metal-binding site 418127002519 argininosuccinate lyase; Provisional; Region: PRK00855 418127002520 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 418127002521 active sites [active] 418127002522 tetramer interface [polypeptide binding]; other site 418127002523 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 418127002524 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 418127002525 ANP binding site [chemical binding]; other site 418127002526 Substrate Binding Site II [chemical binding]; other site 418127002527 Substrate Binding Site I [chemical binding]; other site 418127002528 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 418127002529 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 418127002530 active site 418127002531 dimer interface [polypeptide binding]; other site 418127002532 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 418127002533 dimer interface [polypeptide binding]; other site 418127002534 active site 418127002535 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 418127002536 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 418127002537 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 418127002538 Catalytic site [active] 418127002539 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 418127002540 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 418127002541 Catalytic site [active] 418127002542 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88)...; Region: Peptidase_S24_S26; cl10465 418127002543 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 418127002544 UvrD/REP helicase; Region: UvrD-helicase; cl14126 418127002545 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 418127002546 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 418127002547 helicase-exonuclease AddAB, AddA subunit; Region: addA_Gpos; TIGR02785 418127002548 UvrD/REP helicase; Region: UvrD-helicase; cl14126 418127002549 UvrD/REP helicase; Region: UvrD-helicase; cl14126 418127002550 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 418127002551 Protein of unknown function (DUF1516); Region: DUF1516; cl11654 418127002552 coenzyme A disulfide reductase; Provisional; Region: PRK13512 418127002553 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 418127002554 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 418127002555 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 418127002556 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 418127002557 active site 418127002558 motif I; other site 418127002559 motif II; other site 418127002560 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 418127002561 Domain of unknown function DUF59; Region: DUF59; cl00941 418127002562 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 418127002563 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 418127002564 catalytic triad [active] 418127002565 catalytic triad [active] 418127002566 oxyanion hole [active] 418127002567 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 418127002568 Clp amino terminal domain; Region: Clp_N; pfam02861 418127002569 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 418127002570 Walker A motif; other site 418127002571 ATP binding site [chemical binding]; other site 418127002572 Walker B motif; other site 418127002573 arginine finger; other site 418127002574 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 418127002575 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 418127002576 Walker A motif; other site 418127002577 ATP binding site [chemical binding]; other site 418127002578 Walker B motif; other site 418127002579 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 418127002580 Transcriptional regulator [Transcription]; Region: LysR; COG0583 418127002581 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127002582 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 418127002583 dimerization interface [polypeptide binding]; other site 418127002584 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 418127002585 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 418127002586 active site 418127002587 catalytic residues [active] 418127002588 metal binding site [ion binding]; metal-binding site 418127002589 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 418127002590 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 418127002591 substrate binding site [chemical binding]; other site 418127002592 MAP domain; Region: MAP; pfam03642 418127002593 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 418127002594 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 418127002595 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 418127002596 dimer interface [polypeptide binding]; other site 418127002597 active site 418127002598 CoA binding pocket [chemical binding]; other site 418127002599 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 418127002600 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 418127002601 dimer interface [polypeptide binding]; other site 418127002602 active site 418127002603 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 418127002604 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 418127002605 dimer interface [polypeptide binding]; other site 418127002606 conserved gate region; other site 418127002607 putative PBP binding loops; other site 418127002608 ABC-ATPase subunit interface; other site 418127002609 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 418127002610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 418127002611 dimer interface [polypeptide binding]; other site 418127002612 conserved gate region; other site 418127002613 putative PBP binding loops; other site 418127002614 ABC-ATPase subunit interface; other site 418127002615 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 418127002616 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 418127002617 Walker A/P-loop; other site 418127002618 ATP binding site [chemical binding]; other site 418127002619 Q-loop/lid; other site 418127002620 ABC transporter signature motif; other site 418127002621 Walker B; other site 418127002622 D-loop; other site 418127002623 H-loop/switch region; other site 418127002624 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 418127002625 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 418127002626 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 418127002627 Walker A/P-loop; other site 418127002628 ATP binding site [chemical binding]; other site 418127002629 Q-loop/lid; other site 418127002630 ABC transporter signature motif; other site 418127002631 Walker B; other site 418127002632 D-loop; other site 418127002633 H-loop/switch region; other site 418127002634 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 418127002635 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 418127002636 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 418127002637 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 418127002638 peptide binding site [polypeptide binding]; other site 418127002639 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 418127002640 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 418127002641 peptide binding site [polypeptide binding]; other site 418127002642 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 418127002643 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 418127002644 Walker A/P-loop; other site 418127002645 ATP binding site [chemical binding]; other site 418127002646 Q-loop/lid; other site 418127002647 ABC transporter signature motif; other site 418127002648 Walker B; other site 418127002649 D-loop; other site 418127002650 H-loop/switch region; other site 418127002651 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 418127002652 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 418127002653 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 418127002654 Walker A/P-loop; other site 418127002655 ATP binding site [chemical binding]; other site 418127002656 Q-loop/lid; other site 418127002657 ABC transporter signature motif; other site 418127002658 Walker B; other site 418127002659 D-loop; other site 418127002660 H-loop/switch region; other site 418127002661 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 418127002662 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 418127002663 dimer interface [polypeptide binding]; other site 418127002664 conserved gate region; other site 418127002665 putative PBP binding loops; other site 418127002666 ABC-ATPase subunit interface; other site 418127002667 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 418127002668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 418127002669 dimer interface [polypeptide binding]; other site 418127002670 conserved gate region; other site 418127002671 putative PBP binding loops; other site 418127002672 ABC-ATPase subunit interface; other site 418127002673 tryptophanyl-tRNA synthetase; Region: trpS; TIGR00233 418127002674 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 418127002675 active site 418127002676 HIGH motif; other site 418127002677 dimer interface [polypeptide binding]; other site 418127002678 KMSKS motif; other site 418127002679 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting...; Region: ArsC_Spx; cd03032 418127002680 putative catalytic residues [active] 418127002681 thiol/disulfide switch; other site 418127002682 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 418127002683 Competence protein CoiA-like family; Region: CoiA; cl11541 418127002684 oligoendopeptidase F; Region: pepF; TIGR00181 418127002685 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 418127002686 active site 418127002687 Zn binding site [ion binding]; other site 418127002688 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 418127002689 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 418127002690 catalytic residues [active] 418127002691 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is...; Region: Trunc_globin; cd00454 418127002692 apolar tunnel; other site 418127002693 heme binding site [chemical binding]; other site 418127002694 dimerization interface [polypeptide binding]; other site 418127002695 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 418127002696 putative active site [active] 418127002697 putative metal binding residues [ion binding]; other site 418127002698 signature motif; other site 418127002699 putative triphosphate binding site [ion binding]; other site 418127002700 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 418127002701 synthetase active site [active] 418127002702 NTP binding site [chemical binding]; other site 418127002703 metal binding site [ion binding]; metal-binding site 418127002704 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 418127002705 ATP-NAD kinase; Region: NAD_kinase; pfam01513 418127002706 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 418127002707 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 418127002708 active site 418127002709 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 418127002710 MgtE intracellular N domain; Region: MgtE_N; cl15244 418127002711 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 418127002712 Divalent cation transporter; Region: MgtE; cl00786 418127002713 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 418127002714 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 418127002715 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 418127002716 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127002717 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 418127002718 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 418127002719 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 418127002720 NAD binding site [chemical binding]; other site 418127002721 homotetramer interface [polypeptide binding]; other site 418127002722 homodimer interface [polypeptide binding]; other site 418127002723 substrate binding site [chemical binding]; other site 418127002724 active site 418127002725 Domain of unknown function DUF20; Region: UPF0118; cl00465 418127002726 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 418127002727 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 418127002728 Putative esterase; Region: Esterase; pfam00756 418127002729 hypothetical protein; Provisional; Region: PRK13679 418127002730 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 418127002731 Major Facilitator Superfamily; Region: MFS_1; pfam07690 418127002732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127002733 putative substrate translocation pore; other site 418127002734 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 418127002735 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 418127002736 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 418127002737 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 418127002738 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 418127002739 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 418127002740 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 418127002741 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 418127002742 G4 box; other site 418127002743 G5 box; other site 418127002744 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 418127002745 elongation factor EF-2; Reviewed; Region: PRK07560 418127002746 Integral membrane protein TerC family; Region: TerC; cl10468 418127002747 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 418127002748 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 418127002749 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 418127002750 Cation transport protein; Region: TrkH; cl10514 418127002751 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 418127002752 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 418127002753 active site 418127002754 metal binding site [ion binding]; metal-binding site 418127002755 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 418127002756 ComK protein; Region: ComK; cl11560 418127002757 IDEAL domain; Region: IDEAL; pfam08858 418127002758 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 418127002759 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 418127002760 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 418127002761 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 418127002762 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 418127002763 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 418127002764 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 418127002765 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 418127002766 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 418127002767 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 418127002768 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 418127002769 Walker A/P-loop; other site 418127002770 ATP binding site [chemical binding]; other site 418127002771 Q-loop/lid; other site 418127002772 ABC transporter signature motif; other site 418127002773 Walker B; other site 418127002774 D-loop; other site 418127002775 H-loop/switch region; other site 418127002776 DoxX; Region: DoxX; cl00976 418127002777 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 418127002778 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor...; Region: FhuD; cd01146 418127002779 siderophore binding site; other site 418127002780 TM2 domain; Region: TM2; cl00984 418127002781 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 418127002782 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 418127002783 Coenzyme A binding pocket [chemical binding]; other site 418127002784 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; COG1575 418127002785 UbiA prenyltransferase family; Region: UbiA; cl00337 418127002786 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 418127002787 chorismate binding enzyme; Region: Chorismate_bind; cl10555 418127002788 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 418127002789 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 418127002790 dimer interface [polypeptide binding]; other site 418127002791 tetramer interface [polypeptide binding]; other site 418127002792 PYR/PP interface [polypeptide binding]; other site 418127002793 TPP binding site [chemical binding]; other site 418127002794 TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key role in the menaquinone biosynthetic pathway, converting...; Region: TPP_SHCHC_synthase; cd02009 418127002795 TPP-binding site; other site 418127002796 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 418127002797 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 418127002798 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 418127002799 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 418127002800 substrate binding site [chemical binding]; other site 418127002801 oxyanion hole (OAH) forming residues; other site 418127002802 trimer interface [polypeptide binding]; other site 418127002803 Staphostatin B; Region: Staphostatin_B; pfam09023 418127002804 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 418127002805 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 418127002806 aspartate aminotransferase; Provisional; Region: PRK08361 418127002807 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 418127002808 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127002809 homodimer interface [polypeptide binding]; other site 418127002810 catalytic residue [active] 418127002811 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 418127002812 Acyltransferase family; Region: Acyl_transf_3; pfam01757 418127002813 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127002814 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 418127002815 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 418127002816 amidase catalytic site [active] 418127002817 Zn binding residues [ion binding]; other site 418127002818 substrate binding site [chemical binding]; other site 418127002819 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 418127002820 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 418127002821 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 418127002822 Coenzyme A binding pocket [chemical binding]; other site 418127002823 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 418127002824 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 418127002825 Beta-lactamase; Region: Beta-lactamase; cl01009 418127002826 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 418127002827 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 418127002828 Subunit I/III interface [polypeptide binding]; other site 418127002829 Subunit III/IV interface [polypeptide binding]; other site 418127002830 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 418127002831 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 418127002832 D-pathway; other site 418127002833 Putative ubiquinol binding site [chemical binding]; other site 418127002834 Low-spin heme (heme b) binding site [chemical binding]; other site 418127002835 Putative water exit pathway; other site 418127002836 Binuclear center (heme o3/CuB) [ion binding]; other site 418127002837 K-pathway; other site 418127002838 Putative proton exit pathway; other site 418127002839 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 418127002840 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 418127002841 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 418127002842 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175 418127002843 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 418127002844 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 418127002845 homodimer interface [polypeptide binding]; other site 418127002846 NADP binding site [chemical binding]; other site 418127002847 substrate binding site [chemical binding]; other site 418127002848 AIR carboxylase; Region: AIRC; cl00310 418127002849 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127002850 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 418127002851 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 418127002852 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 418127002853 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 418127002854 ATP binding site [chemical binding]; other site 418127002855 active site 418127002856 substrate binding site [chemical binding]; other site 418127002857 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 418127002858 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 418127002859 putative active site [active] 418127002860 catalytic triad [active] 418127002861 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 418127002862 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203 418127002863 dimerization interface [polypeptide binding]; other site 418127002864 ATP binding site [chemical binding]; other site 418127002865 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204 418127002866 dimerization interface [polypeptide binding]; other site 418127002867 ATP binding site [chemical binding]; other site 418127002868 amidophosphoribosyltransferase; Provisional; Region: PRK07272 418127002869 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 418127002870 active site 418127002871 tetramer interface [polypeptide binding]; other site 418127002872 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 418127002873 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 418127002874 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196 418127002875 dimerization interface [polypeptide binding]; other site 418127002876 putative ATP binding site [chemical binding]; other site 418127002877 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 418127002878 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 418127002879 active site 418127002880 substrate binding site [chemical binding]; other site 418127002881 cosubstrate binding site; other site 418127002882 catalytic site [active] 418127002883 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 418127002884 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421 418127002885 purine monophosphate binding site [chemical binding]; other site 418127002886 dimer interface [polypeptide binding]; other site 418127002887 putative catalytic residues [active] 418127002888 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 418127002889 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 418127002890 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790 418127002891 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 418127002892 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 418127002893 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 418127002894 Cobalt transport protein; Region: CbiQ; cl00463 418127002895 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 418127002896 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 418127002897 Walker A/P-loop; other site 418127002898 ATP binding site [chemical binding]; other site 418127002899 Q-loop/lid; other site 418127002900 ABC transporter signature motif; other site 418127002901 Walker B; other site 418127002902 D-loop; other site 418127002903 H-loop/switch region; other site 418127002904 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 418127002905 Walker A/P-loop; other site 418127002906 ATP binding site [chemical binding]; other site 418127002907 Q-loop/lid; other site 418127002908 ABC transporter signature motif; other site 418127002909 Walker B; other site 418127002910 D-loop; other site 418127002911 H-loop/switch region; other site 418127002912 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 418127002913 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 418127002914 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 418127002915 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 418127002916 dimerization domain swap beta strand [polypeptide binding]; other site 418127002917 regulatory protein interface [polypeptide binding]; other site 418127002918 active site 418127002919 regulatory phosphorylation site [posttranslational modification]; other site 418127002920 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 418127002921 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 418127002922 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 418127002923 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 418127002924 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide...; Region: NrdH; cd02976 418127002925 catalytic residues [active] 418127002926 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 418127002927 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 418127002928 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 418127002929 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127002930 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 418127002931 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 418127002932 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 418127002933 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 418127002934 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 418127002935 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 418127002936 active site 418127002937 catalytic residues [active] 418127002938 metal binding site [ion binding]; metal-binding site 418127002939 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 418127002940 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 418127002941 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 418127002942 TPP-binding site [chemical binding]; other site 418127002943 tetramer interface [polypeptide binding]; other site 418127002944 heterodimer interface [polypeptide binding]; other site 418127002945 phosphorylation loop region [posttranslational modification] 418127002946 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 418127002947 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 418127002948 alpha subunit interface [polypeptide binding]; other site 418127002949 TPP binding site [chemical binding]; other site 418127002950 heterodimer interface [polypeptide binding]; other site 418127002951 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 418127002952 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 418127002953 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 418127002954 E3 interaction surface; other site 418127002955 lipoyl attachment site [posttranslational modification]; other site 418127002956 e3 binding domain; Region: E3_binding; pfam02817 418127002957 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 418127002958 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 418127002959 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 418127002960 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 418127002961 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 418127002962 Uncharacterised protein family (UPF0223); Region: UPF0223; cl11484 418127002963 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 418127002964 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 418127002965 non-specific DNA binding site [nucleotide binding]; other site 418127002966 salt bridge; other site 418127002967 sequence-specific DNA binding site [nucleotide binding]; other site 418127002968 Cupin domain; Region: Cupin_2; cl09118 418127002969 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 418127002970 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 418127002971 Walker A/P-loop; other site 418127002972 ATP binding site [chemical binding]; other site 418127002973 Q-loop/lid; other site 418127002974 ABC transporter signature motif; other site 418127002975 Walker B; other site 418127002976 D-loop; other site 418127002977 H-loop/switch region; other site 418127002978 TOBE domain; Region: TOBE_2; cl01440 418127002979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 418127002980 putative PBP binding loops; other site 418127002981 dimer interface [polypeptide binding]; other site 418127002982 ABC-ATPase subunit interface; other site 418127002983 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 418127002984 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 418127002985 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 418127002986 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 418127002987 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 418127002988 Protein of unknown function (DUF1054); Region: DUF1054; cl11544 418127002989 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1,6-; Region: IMPase_like; cd01637 418127002990 active site 418127002991 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 418127002992 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 418127002993 G1 box; other site 418127002994 putative GEF interaction site [polypeptide binding]; other site 418127002995 GTP/Mg2+ binding site [chemical binding]; other site 418127002996 Switch I region; other site 418127002997 G2 box; other site 418127002998 G3 box; other site 418127002999 Switch II region; other site 418127003000 G4 box; other site 418127003001 G5 box; other site 418127003002 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 418127003003 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a...; Region: BipA_TypA_C; cd03710 418127003004 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; cl11558 418127003005 Protein of unknown function (DUF1507); Region: DUF1507; cl11487 418127003006 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 418127003007 pyruvate carboxylase; Reviewed; Region: PRK12999 418127003008 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 418127003009 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 418127003010 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 418127003011 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 418127003012 active site 418127003013 catalytic residues [active] 418127003014 metal binding site [ion binding]; metal-binding site 418127003015 homodimer binding site [polypeptide binding]; other site 418127003016 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 418127003017 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 418127003018 carboxyltransferase (CT) interaction site; other site 418127003019 biotinylation site [posttranslational modification]; other site 418127003020 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 418127003021 cytochrome c oxidase assembly protein; Provisional; Region: PTZ00127 418127003022 UbiA prenyltransferase family; Region: UbiA; cl00337 418127003023 Protein of unknown function (DUF420); Region: DUF420; cl00989 418127003024 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 418127003025 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 418127003026 Protein of unknown function (DUF964); Region: DUF964; cl01483 418127003027 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 418127003028 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 418127003029 putative active site [active] 418127003030 catalytic site [active] 418127003031 putative metal binding site [ion binding]; other site 418127003032 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 418127003033 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 418127003034 S-adenosylmethionine binding site [chemical binding]; other site 418127003035 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 418127003036 active site 418127003037 (T/H)XGH motif; other site 418127003038 Protein of unknown function (DUF795); Region: DUF795; pfam05636 418127003039 hypothetical protein; Provisional; Region: PRK13671 418127003040 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 418127003041 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 418127003042 heme uptake protein IsdB; Region: IsdB; TIGR03657 418127003043 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 418127003044 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cl02760 418127003045 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 418127003046 heme-binding site [chemical binding]; other site 418127003047 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 418127003048 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 418127003049 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 418127003050 heme-binding site [chemical binding]; other site 418127003051 heme uptake protein IsdC; Region: IsdC; TIGR03656 418127003052 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 418127003053 heme-binding site [chemical binding]; other site 418127003054 sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068 418127003055 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 418127003056 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 418127003057 intersubunit interface [polypeptide binding]; other site 418127003058 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 418127003059 ABC-ATPase subunit interface; other site 418127003060 dimer interface [polypeptide binding]; other site 418127003061 putative PBP binding regions; other site 418127003062 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 418127003063 active site 418127003064 catalytic site [active] 418127003065 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 418127003066 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 418127003067 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 418127003068 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 418127003069 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 418127003070 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 418127003071 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 418127003072 dimer interface [polypeptide binding]; other site 418127003073 motif 1; other site 418127003074 active site 418127003075 motif 2; other site 418127003076 motif 3; other site 418127003077 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 418127003078 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 418127003079 putative tRNA-binding site [nucleotide binding]; other site 418127003080 B3/4 domain; Region: B3_4; cl11458 418127003081 tRNA synthetase B5 domain; Region: B5; cl08394 418127003082 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 418127003083 dimer interface [polypeptide binding]; other site 418127003084 motif 1; other site 418127003085 motif 3; other site 418127003086 motif 2; other site 418127003087 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 418127003088 ribonuclease HIII; Provisional; Region: PRK00996 418127003089 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 418127003090 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 418127003091 RNA/DNA hybrid binding site [nucleotide binding]; other site 418127003092 active site 418127003093 Cell division protein ZapA; Region: ZapA; cl01146 418127003094 Colicin V production protein; Region: Colicin_V; cl00567 418127003095 hypothetical protein; Provisional; Region: PRK08609 418127003096 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 418127003097 active site 418127003098 primer binding site [nucleotide binding]; other site 418127003099 NTP binding site [chemical binding]; other site 418127003100 metal binding triad [ion binding]; metal-binding site 418127003101 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 418127003102 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 418127003103 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 418127003104 Walker A/P-loop; other site 418127003105 ATP binding site [chemical binding]; other site 418127003106 Q-loop/lid; other site 418127003107 ABC transporter signature motif; other site 418127003108 Walker B; other site 418127003109 D-loop; other site 418127003110 H-loop/switch region; other site 418127003111 Smr domain; Region: Smr; cl02619 418127003112 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 418127003113 catalytic residues [active] 418127003114 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 418127003115 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 418127003116 UvrB/uvrC motif; Region: UVR; pfam02151 418127003117 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 418127003118 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus...; Region: SQR_TypeB_1_TM; cd03497 418127003119 putative Iron-sulfur protein interface [polypeptide binding]; other site 418127003120 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 418127003121 proximal heme binding site [chemical binding]; other site 418127003122 distal heme binding site [chemical binding]; other site 418127003123 putative dimer interface [polypeptide binding]; other site 418127003124 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 418127003125 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 418127003126 domain; Region: Succ_DH_flav_C; pfam02910 418127003127 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 418127003128 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 418127003129 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 418127003130 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515 418127003131 active site 418127003132 dimerization interface [polypeptide binding]; other site 418127003133 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 418127003134 active site 418127003135 metal binding site [ion binding]; metal-binding site 418127003136 homotetramer interface [polypeptide binding]; other site 418127003137 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 418127003138 formyl peptide receptor-like 1 inhibitory protein; Reviewed; Region: PRK13033 418127003139 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 418127003140 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 418127003141 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 418127003142 Transposase; Region: DDE_Tnp_ISL3; pfam01610 418127003143 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 418127003144 superantigen-like protein; Reviewed; Region: PRK13350 418127003145 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127003146 superantigen-like protein; Reviewed; Region: PRK13349 418127003147 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127003148 superantigen-like protein; Reviewed; Region: PRK13043 418127003149 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127003150 ornithine carbamoyltransferase; Provisional; Region: PRK04284 418127003151 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 418127003152 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 418127003153 carbamate kinase; Reviewed; Region: PRK12686 418127003154 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 418127003155 putative substrate binding site [chemical binding]; other site 418127003156 nucleotide binding site [chemical binding]; other site 418127003157 nucleotide binding site [chemical binding]; other site 418127003158 homodimer interface [polypeptide binding]; other site 418127003159 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 418127003160 Predicted membrane protein [Function unknown]; Region: COG1288 418127003161 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 418127003162 gating phenylalanine in ion channel; other site 418127003163 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 418127003164 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 418127003165 motif II; other site 418127003166 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 418127003167 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 418127003168 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 418127003169 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 418127003170 MraZ protein; Region: MraZ; pfam02381 418127003171 MraZ protein; Region: MraZ; pfam02381 418127003172 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 418127003173 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 418127003174 Septum formation initiator; Region: DivIC; cl11433 418127003175 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 418127003176 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 418127003177 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 418127003178 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 418127003179 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 418127003180 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 418127003181 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852 418127003182 Mg++ binding site [ion binding]; other site 418127003183 putative catalytic motif [active] 418127003184 putative substrate binding site [chemical binding]; other site 418127003185 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 418127003186 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 418127003187 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 418127003188 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 418127003189 Cell division protein FtsQ; Region: FtsQ; pfam03799 418127003190 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 418127003191 Cell division protein FtsA; Region: FtsA; cl11496 418127003192 Cell division protein FtsA; Region: FtsA; cl11496 418127003193 cell division protein FtsZ; Validated; Region: PRK09330 418127003194 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201 418127003195 nucleotide binding site [chemical binding]; other site 418127003196 SulA interaction site; other site 418127003197 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 418127003198 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 418127003199 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 418127003200 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 418127003201 catalytic residue [active] 418127003202 Protein of unknown function (DUF552); Region: DUF552; cl00775 418127003203 YGGT family; Region: YGGT; cl00508 418127003204 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 418127003205 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 418127003206 RNA binding surface [nucleotide binding]; other site 418127003207 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 418127003208 DivIVA domain; Region: DivI1A_domain; TIGR03544 418127003209 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 418127003210 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 418127003211 HIGH motif; other site 418127003212 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 418127003213 active site 418127003214 KMSKS motif; other site 418127003215 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 418127003216 tRNA binding surface [nucleotide binding]; other site 418127003217 anticodon binding site; other site 418127003218 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 418127003219 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 418127003220 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 418127003221 active site 418127003222 metal binding site [ion binding]; metal-binding site 418127003223 Transposase domain (DUF772); Region: DUF772; cl12084 418127003224 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 418127003225 lipoprotein signal peptidase; Provisional; Region: PRK14787 418127003226 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 418127003227 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 418127003228 RNA binding surface [nucleotide binding]; other site 418127003229 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 418127003230 active site 418127003231 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 418127003232 Sulfate transporter family; Region: Sulfate_transp; cl00967 418127003233 Permease family; Region: Xan_ur_permease; pfam00860 418127003234 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 418127003235 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 418127003236 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 418127003237 dihydroorotase; Validated; Region: pyrC; PRK09357 418127003238 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 418127003239 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C...; Region: DHOase_IIa; cd01317 418127003240 active site 418127003241 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 418127003242 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 418127003243 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 418127003244 catalytic site [active] 418127003245 subunit interface [polypeptide binding]; other site 418127003246 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 418127003247 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 418127003248 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 418127003249 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 418127003250 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 418127003251 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 418127003252 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 418127003253 IMP binding site; other site 418127003254 dimer interface [polypeptide binding]; other site 418127003255 interdomain contacts; other site 418127003256 partial ornithine binding site; other site 418127003257 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 418127003258 active site 418127003259 dimer interface [polypeptide binding]; other site 418127003260 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 418127003261 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 418127003262 dimer interface [polypeptide binding]; other site 418127003263 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 418127003264 Domain of unknown function (DUF814); Region: DUF814; pfam05670 418127003265 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 418127003266 catalytic site [active] 418127003267 G-X2-G-X-G-K; other site 418127003268 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 418127003269 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 418127003270 Flavoprotein; Region: Flavoprotein; cl08021 418127003271 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 418127003272 primosome assembly protein PriA; Validated; Region: PRK05580 418127003273 primosome assembly protein PriA; Validated; Region: PRK05580 418127003274 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 418127003275 ATP binding site [chemical binding]; other site 418127003276 putative Mg++ binding site [ion binding]; other site 418127003277 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 418127003278 TM2 domain; Region: TM2; cl00984 418127003279 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 418127003280 active site 418127003281 catalytic residues [active] 418127003282 metal binding site [ion binding]; metal-binding site 418127003283 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 418127003284 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 418127003285 putative active site [active] 418127003286 substrate binding site [chemical binding]; other site 418127003287 putative cosubstrate binding site; other site 418127003288 catalytic site [active] 418127003289 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 418127003290 substrate binding site [chemical binding]; other site 418127003291 16S rRNA methyltransferase B; Provisional; Region: PRK14902 418127003292 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 418127003293 putative RNA binding site [nucleotide binding]; other site 418127003294 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 418127003295 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 418127003296 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 418127003297 FeS/SAM binding site; other site 418127003298 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 418127003299 Protein phosphatase 2C; Region: PP2C; pfam00481 418127003300 Active site [active] 418127003301 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 418127003302 active site 418127003303 ATP binding site [chemical binding]; other site 418127003304 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 418127003305 substrate binding site [chemical binding]; other site 418127003306 activation loop (A-loop); other site 418127003307 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 418127003308 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 418127003309 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 418127003310 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 418127003311 GTPase RsgA; Reviewed; Region: PRK00098 418127003312 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 418127003313 GTPase/OB domain interface [polypeptide binding]; other site 418127003314 GTPase/Zn-binding domain interface [polypeptide binding]; other site 418127003315 GTP/Mg2+ binding site [chemical binding]; other site 418127003316 G4 box; other site 418127003317 G5 box; other site 418127003318 G1 box; other site 418127003319 Switch I region; other site 418127003320 G2 box; other site 418127003321 G3 box; other site 418127003322 Switch II region; other site 418127003323 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 418127003324 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 418127003325 substrate binding site [chemical binding]; other site 418127003326 hexamer interface [polypeptide binding]; other site 418127003327 metal binding site [ion binding]; metal-binding site 418127003328 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 418127003329 Thiamine pyrophosphokinase; Region: TPK; cd07995 418127003330 active site 418127003331 dimerization interface [polypeptide binding]; other site 418127003332 thiamine binding site [chemical binding]; other site 418127003333 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 418127003334 Protein of unknown function (DUF322); Region: DUF322; cl00574 418127003335 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 418127003336 DAK2 domain; Region: Dak2; cl03685 418127003337 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 418127003338 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 418127003339 generic binding surface II; other site 418127003340 ssDNA binding site; other site 418127003341 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 418127003342 ATP binding site [chemical binding]; other site 418127003343 putative Mg++ binding site [ion binding]; other site 418127003344 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 418127003345 nucleotide binding region [chemical binding]; other site 418127003346 ATP-binding site [chemical binding]; other site 418127003347 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 418127003348 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 418127003349 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 418127003350 Acyl transferase domain; Region: Acyl_transf_1; cl08282 418127003351 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 418127003352 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 418127003353 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 418127003354 NAD(P) binding site [chemical binding]; other site 418127003355 homotetramer interface [polypeptide binding]; other site 418127003356 homodimer interface [polypeptide binding]; other site 418127003357 active site 418127003358 Phosphopantetheine attachment site; Region: PP-binding; cl09936 418127003359 ribonuclease III; Reviewed; Region: rnc; PRK00102 418127003360 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 418127003361 dimerization interface [polypeptide binding]; other site 418127003362 active site 418127003363 metal binding site [ion binding]; metal-binding site 418127003364 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048 418127003365 dsRNA binding site [nucleotide binding]; other site 418127003366 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 418127003367 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 418127003368 Walker A/P-loop; other site 418127003369 ATP binding site [chemical binding]; other site 418127003370 Q-loop/lid; other site 418127003371 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cl00148 418127003372 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 418127003373 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 418127003374 ABC transporter signature motif; other site 418127003375 Walker B; other site 418127003376 D-loop; other site 418127003377 H-loop/switch region; other site 418127003378 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 418127003379 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 418127003380 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 418127003381 P loop; other site 418127003382 GTP binding site [chemical binding]; other site 418127003383 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 418127003384 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 418127003385 signal recognition particle protein; Provisional; Region: PRK10867 418127003386 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 418127003387 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 418127003388 P loop; other site 418127003389 GTP binding site [chemical binding]; other site 418127003390 Signal peptide binding domain; Region: SRP_SPB; pfam02978 418127003391 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 418127003392 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 418127003393 RimM N-terminal domain; Region: RimM; pfam01782 418127003394 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 418127003395 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 418127003396 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 418127003397 Predicted membrane protein [Function unknown]; Region: COG4485 418127003398 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 418127003399 YlqF. Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases...; Region: YlqF; cd01856 418127003400 GTP/Mg2+ binding site [chemical binding]; other site 418127003401 G4 box; other site 418127003402 G5 box; other site 418127003403 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 418127003404 G1 box; other site 418127003405 G1 box; other site 418127003406 GTP/Mg2+ binding site [chemical binding]; other site 418127003407 Switch I region; other site 418127003408 Switch I region; other site 418127003409 G2 box; other site 418127003410 G2 box; other site 418127003411 Switch II region; other site 418127003412 G3 box; other site 418127003413 G3 box; other site 418127003414 Switch II region; other site 418127003415 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 418127003416 RNA/DNA hybrid binding site [nucleotide binding]; other site 418127003417 active site 418127003418 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 418127003419 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 418127003420 CoA-ligase; Region: Ligase_CoA; pfam00549 418127003421 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 418127003422 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127003423 CoA-ligase; Region: Ligase_CoA; pfam00549 418127003424 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 418127003425 autolysin; Reviewed; Region: PRK06347 418127003426 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 418127003427 putative peptidoglycan binding site; other site 418127003428 NlpC/P60 family; Region: NLPC_P60; cl11438 418127003429 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 418127003430 FemAB family; Region: FemAB; cl11444 418127003431 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 418127003432 DNA topoisomerase I; Validated; Region: PRK05582 418127003433 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363 418127003434 active site 418127003435 interdomain interaction site; other site 418127003436 putative metal-binding site [ion binding]; other site 418127003437 nucleotide binding site [chemical binding]; other site 418127003438 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 418127003439 domain I; other site 418127003440 DNA binding groove [nucleotide binding] 418127003441 phosphate binding site [ion binding]; other site 418127003442 domain II; other site 418127003443 domain III; other site 418127003444 nucleotide binding site [chemical binding]; other site 418127003445 catalytic site [active] 418127003446 domain IV; other site 418127003447 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 418127003448 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 418127003449 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; cl11520 418127003450 Glucose inhibited division protein A; Region: GIDA; pfam01134 418127003451 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 418127003452 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 418127003453 DNA binding site [nucleotide binding] 418127003454 Int/Topo IB signature motif; other site 418127003455 active site 418127003456 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 418127003457 active site 418127003458 HslU subunit interaction site [polypeptide binding]; other site 418127003459 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 418127003460 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 418127003461 Walker A motif; other site 418127003462 ATP binding site [chemical binding]; other site 418127003463 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 418127003464 transcriptional repressor CodY; Validated; Region: PRK04158 418127003465 CodY GAF-like domain; Region: CodY; pfam06018 418127003466 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 418127003467 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 418127003468 rRNA interaction site [nucleotide binding]; other site 418127003469 S8 interaction site; other site 418127003470 putative laminin-1 binding site; other site 418127003471 elongation factor Ts; Provisional; Region: tsf; PRK09377 418127003472 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 418127003473 Elongation factor TS; Region: EF_TS; pfam00889 418127003474 Elongation factor TS; Region: EF_TS; pfam00889 418127003475 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 418127003476 putative nucleotide binding site [chemical binding]; other site 418127003477 uridine monophosphate binding site [chemical binding]; other site 418127003478 homohexameric interface [polypeptide binding]; other site 418127003479 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 418127003480 hinge region; other site 418127003481 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 418127003482 catalytic residue [active] 418127003483 putative FPP diphosphate binding site; other site 418127003484 putative FPP binding hydrophobic cleft; other site 418127003485 dimer interface [polypeptide binding]; other site 418127003486 putative IPP diphosphate binding site; other site 418127003487 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 418127003488 RIP metalloprotease RseP; Region: TIGR00054 418127003489 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 418127003490 active site 418127003491 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 418127003492 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 418127003493 protein binding site [polypeptide binding]; other site 418127003494 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 418127003495 putative substrate binding region [chemical binding]; other site 418127003496 prolyl-tRNA synthetase; Provisional; Region: PRK09194 418127003497 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779 418127003498 dimer interface [polypeptide binding]; other site 418127003499 motif 1; other site 418127003500 active site 418127003501 motif 2; other site 418127003502 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334 418127003503 putative deacylase active site [active] 418127003504 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 418127003505 active site 418127003506 motif 3; other site 418127003507 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861 418127003508 anticodon binding site; other site 418127003509 DNA polymerase III PolC; Validated; Region: polC; PRK00448 418127003510 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 418127003511 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 418127003512 generic binding surface II; other site 418127003513 generic binding surface I; other site 418127003514 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 418127003515 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 418127003516 active site 418127003517 substrate binding site [chemical binding]; other site 418127003518 catalytic site [active] 418127003519 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 418127003520 ribosome maturation protein RimP; Reviewed; Region: PRK00092 418127003521 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 418127003522 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 418127003523 Sm1 motif; other site 418127003524 predicted subunit interaction site [polypeptide binding]; other site 418127003525 RNA binding pocket [nucleotide binding]; other site 418127003526 Sm2 motif; other site 418127003527 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 418127003528 NusA N-terminal domain; Region: NusA_N; pfam08529 418127003529 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455 418127003530 RNA binding site [nucleotide binding]; other site 418127003531 homodimer interface [polypeptide binding]; other site 418127003532 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 418127003533 G-X-X-G motif; other site 418127003534 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 418127003535 putative RNA binding cleft [nucleotide binding]; other site 418127003536 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 418127003537 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 418127003538 translation initiation factor IF-2; Region: IF-2; TIGR00487 418127003539 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 418127003540 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 418127003541 G1 box; other site 418127003542 putative GEF interaction site [polypeptide binding]; other site 418127003543 GTP/Mg2+ binding site [chemical binding]; other site 418127003544 Switch I region; other site 418127003545 G2 box; other site 418127003546 G3 box; other site 418127003547 Switch II region; other site 418127003548 G4 box; other site 418127003549 G5 box; other site 418127003550 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 418127003551 Translation-initiation factor 2; Region: IF-2; pfam11987 418127003552 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 418127003553 Ribosome-binding factor A; Region: RBFA; cl00542 418127003554 tRNA pseudouridine synthase B; Provisional; Region: PRK14123 418127003555 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 418127003556 RNA binding site [nucleotide binding]; other site 418127003557 active site 418127003558 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 418127003559 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 418127003560 active site 418127003561 Riboflavin kinase; Region: Flavokinase; pfam01687 418127003562 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 418127003563 16S/18S rRNA binding site [nucleotide binding]; other site 418127003564 S13e-L30e interaction site [polypeptide binding]; other site 418127003565 25S rRNA binding site [nucleotide binding]; other site 418127003566 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 418127003567 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 418127003568 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 418127003569 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 418127003570 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 418127003571 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 418127003572 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 418127003573 putative nucleic acid binding region [nucleotide binding]; other site 418127003574 G-X-X-G motif; other site 418127003575 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472 418127003576 RNA binding site [nucleotide binding]; other site 418127003577 domain interface; other site 418127003578 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 418127003579 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 418127003580 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 418127003581 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 418127003582 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 418127003583 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 418127003584 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 418127003585 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 418127003586 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127003587 UTRA domain; Region: UTRA; cl06649 418127003588 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 418127003589 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 418127003590 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 418127003591 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 418127003592 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 418127003593 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 418127003594 classical (c) SDRs; Region: SDR_c; cd05233 418127003595 NAD(P) binding site [chemical binding]; other site 418127003596 active site 418127003597 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 418127003598 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 418127003599 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 418127003600 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 418127003601 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 418127003602 putative MPT binding site; other site 418127003603 recombinase A; Provisional; Region: recA; PRK09354 418127003604 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 418127003605 hexamer interface [polypeptide binding]; other site 418127003606 Walker A motif; other site 418127003607 ATP binding site [chemical binding]; other site 418127003608 Walker B motif; other site 418127003609 phosphodiesterase; Provisional; Region: PRK12704 418127003610 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 418127003611 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 418127003612 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 418127003613 putative active site [active] 418127003614 metal binding site [ion binding]; metal-binding site 418127003615 homodimer binding site [polypeptide binding]; other site 418127003616 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 418127003617 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 418127003618 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 418127003619 dimer interface [polypeptide binding]; other site 418127003620 PYR/PP interface [polypeptide binding]; other site 418127003621 TPP binding site [chemical binding]; other site 418127003622 substrate binding site [chemical binding]; other site 418127003623 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 418127003624 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 418127003625 TPP-binding site [chemical binding]; other site 418127003626 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 418127003627 Domain of unknown function DUF77; Region: DUF77; cl00307 418127003628 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 418127003629 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 418127003630 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 418127003631 FeS/SAM binding site; other site 418127003632 TRAM domain; Region: TRAM; cl01282 418127003633 Protein of unknown function (DUF964); Region: DUF964; cl01483 418127003634 Thiamine-precursor transporter protein (ThiW); Region: ThiW; cl01952 418127003635 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 418127003636 MutS domain I; Region: MutS_I; pfam01624 418127003637 MutS domain II; Region: MutS_II; pfam05188 418127003638 MutS family domain IV; Region: MutS_IV; pfam05190 418127003639 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 418127003640 Walker A/P-loop; other site 418127003641 ATP binding site [chemical binding]; other site 418127003642 Q-loop/lid; other site 418127003643 ABC transporter signature motif; other site 418127003644 Walker B; other site 418127003645 D-loop; other site 418127003646 H-loop/switch region; other site 418127003647 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 418127003648 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 418127003649 ATP binding site [chemical binding]; other site 418127003650 Mg2+ binding site [ion binding]; other site 418127003651 G-X-G motif; other site 418127003652 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 418127003653 ATP binding site [chemical binding]; other site 418127003654 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 418127003655 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 418127003656 similar to hypothetical protein 418127003657 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cd00333 418127003658 amphipathic channel; other site 418127003659 Asn-Pro-Ala signature motifs; other site 418127003660 glycerol kinase; Provisional; Region: glpK; PRK00047 418127003661 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 418127003662 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 418127003663 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 418127003664 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 418127003665 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 418127003666 IPP transferase; Region: IPPT; cl00403 418127003667 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 418127003668 Sm1 motif; other site 418127003669 intra - hexamer interaction site; other site 418127003670 inter - hexamer interaction site [polypeptide binding]; other site 418127003671 nucleotide binding pocket [chemical binding]; other site 418127003672 Sm2 motif; other site 418127003673 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340 418127003674 catalytic residues [active] 418127003675 dimer interface [polypeptide binding]; other site 418127003676 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 418127003677 Restriction endonuclease; Region: Mrr_cat; cl00747 418127003678 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 418127003679 G1 box; other site 418127003680 GTP/Mg2+ binding site [chemical binding]; other site 418127003681 Switch I region; other site 418127003682 G2 box; other site 418127003683 G3 box; other site 418127003684 Switch II region; other site 418127003685 G4 box; other site 418127003686 G5 box; other site 418127003687 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 418127003688 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 418127003689 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 418127003690 DNA binding residues [nucleotide binding] 418127003691 putative dimer interface [polypeptide binding]; other site 418127003692 glutamine synthetase, type I; Region: GlnA; TIGR00653 418127003693 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 418127003694 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 418127003695 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 418127003696 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 418127003697 catalytic residue [active] 418127003698 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 418127003699 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 418127003700 putative active site [active] 418127003701 catalytic site [active] 418127003702 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 418127003703 putative active site [active] 418127003704 catalytic site [active] 418127003705 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 418127003706 Walker A/P-loop; other site 418127003707 ATP binding site [chemical binding]; other site 418127003708 Q-loop/lid; other site 418127003709 ABC transporter signature motif; other site 418127003710 Walker B; other site 418127003711 D-loop; other site 418127003712 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 418127003713 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 418127003714 Histidine kinase; Region: HisKA_3; pfam07730 418127003715 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 418127003716 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 418127003717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 418127003718 active site 418127003719 phosphorylation site [posttranslational modification] 418127003720 intermolecular recognition site; other site 418127003721 dimerization interface [polypeptide binding]; other site 418127003722 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 418127003723 DNA binding residues [nucleotide binding] 418127003724 dimerization interface [polypeptide binding]; other site 418127003725 Staphylococcal nuclease homologues; Region: SNc; smart00318 418127003726 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 418127003727 Catalytic site; other site 418127003728 aspartate kinase; Reviewed; Region: PRK09034 418127003729 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 418127003730 putative catalytic residues [active] 418127003731 putative nucleotide binding site [chemical binding]; other site 418127003732 putative aspartate binding site [chemical binding]; other site 418127003733 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 418127003734 allosteric regulatory residue; other site 418127003735 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 418127003736 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 418127003737 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127003738 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 418127003739 threonine synthase; Reviewed; Region: PRK06721 418127003740 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants...; Region: Thr-synth_1; cd01563 418127003741 homodimer interface [polypeptide binding]; other site 418127003742 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127003743 catalytic residue [active] 418127003744 homoserine kinase; Provisional; Region: PRK01212 418127003745 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 418127003746 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 418127003747 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 418127003748 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 418127003749 active site 418127003750 motif I; other site 418127003751 motif II; other site 418127003752 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 418127003753 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 418127003754 Amino acid permease; Region: AA_permease; pfam00324 418127003755 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 418127003756 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 418127003757 tetramer interface [polypeptide binding]; other site 418127003758 heme binding pocket [chemical binding]; other site 418127003759 NADPH binding site [chemical binding]; other site 418127003760 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 418127003761 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 418127003762 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 418127003763 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 418127003764 active site 418127003765 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 418127003766 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 418127003767 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127003768 LexA repressor; Validated; Region: PRK00215 418127003769 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 418127003770 Catalytic site [active] 418127003771 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 418127003772 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 418127003773 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 418127003774 TPP-binding site [chemical binding]; other site 418127003775 dimer interface [polypeptide binding]; other site 418127003776 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 418127003777 PYR/PP interface [polypeptide binding]; other site 418127003778 dimer interface [polypeptide binding]; other site 418127003779 TPP binding site [chemical binding]; other site 418127003780 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 418127003781 Uncharacterised protein family (UPF0154); Region: UPF0154; cl01536 418127003782 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 418127003783 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 418127003784 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 418127003785 active site 418127003786 metal binding site [ion binding]; metal-binding site 418127003787 DNA binding site [nucleotide binding] 418127003788 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 418127003789 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 418127003790 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 418127003791 Walker A/P-loop; other site 418127003792 ATP binding site [chemical binding]; other site 418127003793 Q-loop/lid; other site 418127003794 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 418127003795 ABC transporter signature motif; other site 418127003796 Walker B; other site 418127003797 D-loop; other site 418127003798 H-loop/switch region; other site 418127003799 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 418127003800 BCCT family transporter; Region: BCCT; cl00569 418127003801 aconitate hydratase; Validated; Region: PRK09277 418127003802 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 418127003803 substrate binding site [chemical binding]; other site 418127003804 ligand binding site [chemical binding]; other site 418127003805 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 418127003806 substrate binding site [chemical binding]; other site 418127003807 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 418127003808 active site 418127003809 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 418127003810 Domain of unknown function (DUF205); Region: DUF205; cl00410 418127003811 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 418127003812 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 418127003813 ATP binding site [chemical binding]; other site 418127003814 Mg2+ binding site [ion binding]; other site 418127003815 G-X-G motif; other site 418127003816 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 418127003817 anchoring element; other site 418127003818 dimer interface [polypeptide binding]; other site 418127003819 ATP binding site [chemical binding]; other site 418127003820 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 418127003821 active site 418127003822 putative metal-binding site [ion binding]; other site 418127003823 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 418127003824 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 418127003825 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 418127003826 CAP-like domain; other site 418127003827 Active site [active] 418127003828 primary dimer interface [polypeptide binding]; other site 418127003829 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 418127003830 CAT RNA binding domain; Region: CAT_RBD; pfam03123 418127003831 PRD domain; Region: PRD; pfam00874 418127003832 PRD domain; Region: PRD; pfam00874 418127003833 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 418127003834 Domain of unknown function DUF20; Region: UPF0118; cl00465 418127003835 Predicted integral membrane protein [Function unknown]; Region: COG0392 418127003836 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 418127003837 Uncharacterized conserved protein [Function unknown]; Region: COG2898 418127003838 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 418127003839 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 418127003840 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 418127003841 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 418127003842 active site 1 [active] 418127003843 dimer interface [polypeptide binding]; other site 418127003844 hexamer interface [polypeptide binding]; other site 418127003845 active site 2 [active] 418127003846 DNA polymerase IV; Reviewed; Region: PRK03103 418127003847 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 418127003848 active site 418127003849 DNA binding site [nucleotide binding] 418127003850 prephenate dehydrogenase; Validated; Region: PRK06545 418127003851 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127003852 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 418127003853 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 418127003854 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 418127003855 putative oligomer interface [polypeptide binding]; other site 418127003856 putative active site [active] 418127003857 metal binding site [ion binding]; metal-binding site 418127003858 anthranilate synthase component I; Provisional; Region: PRK13567 418127003859 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 418127003860 chorismate binding enzyme; Region: Chorismate_bind; cl10555 418127003861 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 418127003862 Glutamine amidotransferase class-I; Region: GATase; pfam00117 418127003863 glutamine binding [chemical binding]; other site 418127003864 catalytic triad [active] 418127003865 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 418127003866 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 418127003867 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 418127003868 active site 418127003869 ribulose/triose binding site [chemical binding]; other site 418127003870 phosphate binding site [ion binding]; other site 418127003871 substrate (anthranilate) binding pocket [chemical binding]; other site 418127003872 product (indole) binding pocket [chemical binding]; other site 418127003873 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric...; Region: PRAI; cd00405 418127003874 active site 418127003875 tryptophan synthase, beta chain; Region: PLN02618 418127003876 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 418127003877 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127003878 catalytic residue [active] 418127003879 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 418127003880 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724 418127003881 substrate binding site [chemical binding]; other site 418127003882 active site 418127003883 catalytic residues [active] 418127003884 heterodimer interface [polypeptide binding]; other site 418127003885 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 418127003886 FemAB family; Region: FemAB; cl11444 418127003887 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 418127003888 FemAB family; Region: FemAB; cl11444 418127003889 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 418127003890 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 418127003891 active site 418127003892 motif I; other site 418127003893 motif II; other site 418127003894 SWIM zinc finger; Region: SWIM; cl11618 418127003895 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 418127003896 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 418127003897 Walker A/P-loop; other site 418127003898 ATP binding site [chemical binding]; other site 418127003899 Q-loop/lid; other site 418127003900 ABC transporter signature motif; other site 418127003901 Walker B; other site 418127003902 D-loop; other site 418127003903 H-loop/switch region; other site 418127003904 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 418127003905 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 418127003906 Walker A/P-loop; other site 418127003907 ATP binding site [chemical binding]; other site 418127003908 Q-loop/lid; other site 418127003909 ABC transporter signature motif; other site 418127003910 Walker B; other site 418127003911 D-loop; other site 418127003912 H-loop/switch region; other site 418127003913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 418127003914 dimer interface [polypeptide binding]; other site 418127003915 conserved gate region; other site 418127003916 putative PBP binding loops; other site 418127003917 ABC-ATPase subunit interface; other site 418127003918 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 418127003919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 418127003920 dimer interface [polypeptide binding]; other site 418127003921 conserved gate region; other site 418127003922 putative PBP binding loops; other site 418127003923 ABC-ATPase subunit interface; other site 418127003924 Inorganic H+ pyrophosphatase; Region: H_PPase; cl11452 418127003925 oligoendopeptidase F; Region: pepF; TIGR00181 418127003926 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 418127003927 active site 418127003928 Zn binding site [ion binding]; other site 418127003929 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 418127003930 PhoU domain; Region: PhoU; pfam01895 418127003931 PhoU domain; Region: PhoU; pfam01895 418127003932 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 418127003933 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 418127003934 Walker A/P-loop; other site 418127003935 ATP binding site [chemical binding]; other site 418127003936 Q-loop/lid; other site 418127003937 ABC transporter signature motif; other site 418127003938 Walker B; other site 418127003939 D-loop; other site 418127003940 H-loop/switch region; other site 418127003941 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 418127003942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 418127003943 dimer interface [polypeptide binding]; other site 418127003944 conserved gate region; other site 418127003945 putative PBP binding loops; other site 418127003946 ABC-ATPase subunit interface; other site 418127003947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 418127003948 dimer interface [polypeptide binding]; other site 418127003949 conserved gate region; other site 418127003950 ABC-ATPase subunit interface; other site 418127003951 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 418127003952 Transposase domain (DUF772); Region: DUF772; cl12084 418127003953 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 418127003954 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 418127003955 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 418127003956 Walker A/P-loop; other site 418127003957 ATP binding site [chemical binding]; other site 418127003958 Q-loop/lid; other site 418127003959 ABC transporter signature motif; other site 418127003960 Walker B; other site 418127003961 D-loop; other site 418127003962 H-loop/switch region; other site 418127003963 ABC transporter; Region: ABC_tran_2; pfam12848 418127003964 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 418127003965 aspartate kinase; Reviewed; Region: PRK06635 418127003966 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 418127003967 putative nucleotide binding site [chemical binding]; other site 418127003968 putative catalytic residues [active] 418127003969 putative Mg ion binding site [ion binding]; other site 418127003970 putative aspartate binding site [chemical binding]; other site 418127003971 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 418127003972 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 418127003973 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 418127003974 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127003975 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 418127003976 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 418127003977 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 418127003978 dimer interface [polypeptide binding]; other site 418127003979 active site 418127003980 catalytic residue [active] 418127003981 dihydrodipicolinate reductase; Provisional; Region: PRK00048 418127003982 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127003983 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 418127003984 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapD_N; pfam08503 418127003985 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 418127003986 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA...; Region: LbH_THP_succinylT; cd03350 418127003987 active site 418127003988 trimer interface [polypeptide binding]; other site 418127003989 substrate binding site [chemical binding]; other site 418127003990 CoA binding site [chemical binding]; other site 418127003991 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 418127003992 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 418127003993 metal binding site [ion binding]; metal-binding site 418127003994 dimer interface [polypeptide binding]; other site 418127003995 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 418127003996 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 418127003997 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 418127003998 catalytic residue [active] 418127003999 diaminopimelate decarboxylase; Region: lysA; TIGR01048 418127004000 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 418127004001 active site 418127004002 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 418127004003 substrate binding site [chemical binding]; other site 418127004004 catalytic residues [active] 418127004005 dimer interface [polypeptide binding]; other site 418127004006 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 418127004007 DNA-binding site [nucleotide binding]; DNA binding site 418127004008 RNA-binding motif; other site 418127004009 Protein of unknown function (DUF1033); Region: DUF1033; cl11549 418127004010 Acylphosphatase; Region: Acylphosphatase; cl00551 418127004011 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 418127004012 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 418127004013 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 418127004014 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 418127004015 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 418127004016 metal ion-dependent adhesion site (MIDAS); other site 418127004017 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 418127004018 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 418127004019 Walker A motif; other site 418127004020 ATP binding site [chemical binding]; other site 418127004021 Walker B motif; other site 418127004022 arginine finger; other site 418127004023 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 418127004024 active site 418127004025 metal binding site [ion binding]; metal-binding site 418127004026 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 418127004027 active site 418127004028 metal binding site [ion binding]; metal-binding site 418127004029 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 418127004030 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 418127004031 E3 interaction surface; other site 418127004032 lipoyl attachment site [posttranslational modification]; other site 418127004033 e3 binding domain; Region: E3_binding; pfam02817 418127004034 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 418127004035 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 418127004036 TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of...; Region: TPP_E1_OGDC_like; cd02016 418127004037 TPP-binding site [chemical binding]; other site 418127004038 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 418127004039 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 418127004040 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 418127004041 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 418127004042 dimer interface [polypeptide binding]; other site 418127004043 phosphorylation site [posttranslational modification] 418127004044 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 418127004045 ATP binding site [chemical binding]; other site 418127004046 G-X-G motif; other site 418127004047 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 418127004048 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 418127004049 active site 418127004050 phosphorylation site [posttranslational modification] 418127004051 intermolecular recognition site; other site 418127004052 dimerization interface [polypeptide binding]; other site 418127004053 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 418127004054 DNA binding site [nucleotide binding] 418127004055 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 418127004056 active site 418127004057 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 418127004058 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 418127004059 active site 418127004060 homodimer interface [polypeptide binding]; other site 418127004061 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 418127004062 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 418127004063 C-terminal peptidase (prc); Region: prc; TIGR00225 418127004064 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 418127004065 protein binding site [polypeptide binding]; other site 418127004066 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 418127004067 Catalytic dyad [active] 418127004068 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 418127004069 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 418127004070 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162 418127004071 HPr interaction site; other site 418127004072 glycerol kinase (GK) interaction site [polypeptide binding]; other site 418127004073 active site 418127004074 phosphorylation site [posttranslational modification] 418127004075 SelR domain; Region: SelR; cl00369 418127004076 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 418127004077 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 418127004078 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209 418127004079 folate binding site [chemical binding]; other site 418127004080 NADP+ binding site [chemical binding]; other site 418127004081 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 418127004082 dimerization interface [polypeptide binding]; other site 418127004083 active site 418127004084 Protein of unknown function (DUF1094); Region: DUF1094; pfam06491 418127004085 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 418127004086 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 418127004087 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 418127004088 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 418127004089 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 418127004090 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 418127004091 RNA/DNA hybrid binding site [nucleotide binding]; other site 418127004092 active site 418127004093 GA module; Region: GA; cl08325 418127004094 GA module; Region: GA; cl08325 418127004095 GA module; Region: GA; cl08325 418127004096 GA module; Region: GA; cl08325 418127004097 GA module; Region: GA; cl08325 418127004098 GA module; Region: GA; cl08325 418127004099 GA module; Region: GA; cl08325 418127004100 GA module; Region: GA; cl08325 418127004101 GA module; Region: GA; cl08325 418127004102 GA module; Region: GA; cl08325 418127004103 GA module; Region: GA; cl08325 418127004104 GA module; Region: GA; cl08325 418127004105 GA module; Region: GA; cl08325 418127004106 GA module; Region: GA; cl08325 418127004107 GA module; Region: GA; cl08325 418127004108 GA module; Region: GA; cl08325 418127004109 GA module; Region: GA; cl08325 418127004110 GA module; Region: GA; cl08325 418127004111 GA module; Region: GA; cl08325 418127004112 GA module; Region: GA; cl08325 418127004113 GA module; Region: GA; cl08325 418127004114 GA module; Region: GA; cl08325 418127004115 GA module; Region: GA; cl08325 418127004116 GA module; Region: GA; cl08325 418127004117 GA module; Region: GA; cl08325 418127004118 GA module; Region: GA; cl08325 418127004119 hypothetical protein; Provisional; Region: PRK11281 418127004120 GA module; Region: GA; cl08325 418127004121 GA module; Region: GA; cl08325 418127004122 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 418127004123 GA module; Region: GA; cl08325 418127004124 GA module; Region: GA; cl08325 418127004125 GA module; Region: GA; cl08325 418127004126 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 418127004127 Transmembrane protein; Region: Macoilin; pfam09726 418127004128 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 418127004129 GA module; Region: GA; cl08325 418127004130 Uncharacterised Sugar-binding Domain; Region: FIVAR; pfam07554 418127004131 GA module; Region: GA; cl08325 418127004132 GA module; Region: GA; cl08325 418127004133 Uncharacterised Sugar-binding Domain; Region: FIVAR; pfam07554 418127004134 GA module; Region: GA; cl08325 418127004135 Uncharacterised Sugar-binding Domain; Region: FIVAR; pfam07554 418127004136 GA module; Region: GA; cl08325 418127004137 Uncharacterised Sugar-binding Domain; Region: FIVAR; pfam07554 418127004138 GA module; Region: GA; cl08325 418127004139 Uncharacterised Sugar-binding Domain; Region: FIVAR; pfam07554 418127004140 GA module; Region: GA; cl08325 418127004141 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 418127004142 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 418127004143 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 418127004144 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 418127004145 tetramer interface [polypeptide binding]; other site 418127004146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127004147 catalytic residue [active] 418127004148 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 418127004149 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 418127004150 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127004151 NAD(P) binding pocket [chemical binding]; other site 418127004152 5'-3' exonuclease; Region: 53EXOc; smart00475 418127004153 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 418127004154 active site 418127004155 metal binding site 1 [ion binding]; metal-binding site 418127004156 putative 5' ssDNA interaction site; other site 418127004157 metal binding site 3; metal-binding site 418127004158 metal binding site 2 [ion binding]; metal-binding site 418127004159 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 418127004160 putative DNA binding site [nucleotide binding]; other site 418127004161 putative metal binding site [ion binding]; other site 418127004162 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 418127004163 G1 box; other site 418127004164 GTP/Mg2+ binding site [chemical binding]; other site 418127004165 Switch I region; other site 418127004166 G2 box; other site 418127004167 Switch II region; other site 418127004168 G3 box; other site 418127004169 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 418127004170 G4 box; other site 418127004171 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 418127004172 G1 box; other site 418127004173 GTP/Mg2+ binding site [chemical binding]; other site 418127004174 Switch I region; other site 418127004175 G2 box; other site 418127004176 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 418127004177 G3 box; other site 418127004178 Switch II region; other site 418127004179 GTP/Mg2+ binding site [chemical binding]; other site 418127004180 G4 box; other site 418127004181 G5 box; other site 418127004182 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 418127004183 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 418127004184 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 418127004185 cell division protein GpsB; Provisional; Region: PRK14127 418127004186 DivIVA domain; Region: DivI1A_domain; TIGR03544 418127004187 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 418127004188 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 418127004189 Recombination protein U; Region: RecU; cl01314 418127004190 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 418127004191 Transglycosylase; Region: Transgly; cl07896 418127004192 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 418127004193 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 418127004194 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 418127004195 minor groove reading motif; other site 418127004196 helix-hairpin-helix signature motif; other site 418127004197 substrate binding pocket [chemical binding]; other site 418127004198 active site 418127004199 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 418127004200 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 418127004201 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 418127004202 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 418127004203 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 418127004204 putative dimer interface [polypeptide binding]; other site 418127004205 putative anticodon binding site; other site 418127004206 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well...; Region: AsxRS_core; cd00776 418127004207 homodimer interface [polypeptide binding]; other site 418127004208 motif 1; other site 418127004209 motif 2; other site 418127004210 active site 418127004211 motif 3; other site 418127004212 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 418127004213 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 418127004214 active site 418127004215 substrate binding site [chemical binding]; other site 418127004216 catalytic site [active] 418127004217 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl09250 418127004218 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl09250 418127004219 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127004220 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 418127004221 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 418127004222 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 418127004223 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 418127004224 active site 418127004225 NTP binding site [chemical binding]; other site 418127004226 metal binding triad [ion binding]; metal-binding site 418127004227 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 418127004228 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 418127004229 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_5; cd04962 418127004230 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 418127004231 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 418127004232 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 418127004233 Uncharacterized conserved protein [Function unknown]; Region: COG5582 418127004234 UPF0302 domain; Region: UPF0302; pfam08864 418127004235 IDEAL domain; Region: IDEAL; pfam08858 418127004236 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 418127004237 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 418127004238 binding surface 418127004239 TPR motif; other site 418127004240 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 418127004241 binding surface 418127004242 TPR motif; other site 418127004243 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 418127004244 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556 418127004245 hinge; other site 418127004246 active site 418127004247 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 418127004248 active site 418127004249 NAD binding site [chemical binding]; other site 418127004250 metal binding site [ion binding]; metal-binding site 418127004251 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 418127004252 Tetramer interface [polypeptide binding]; other site 418127004253 Active site [active] 418127004254 FMN-binding site [chemical binding]; other site 418127004255 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 418127004256 active site 418127004257 multimer interface [polypeptide binding]; other site 418127004258 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 418127004259 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 418127004260 substrate binding pocket [chemical binding]; other site 418127004261 chain length determination region; other site 418127004262 substrate-Mg2+ binding site; other site 418127004263 catalytic residues [active] 418127004264 aspartate-rich region 1; other site 418127004265 active site lid residues [active] 418127004266 aspartate-rich region 2; other site 418127004267 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 418127004268 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 418127004269 S-adenosylmethionine binding site [chemical binding]; other site 418127004270 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 418127004271 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 418127004272 IHF dimer interface [polypeptide binding]; other site 418127004273 IHF - DNA interface [nucleotide binding]; other site 418127004274 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 418127004275 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127004276 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 418127004277 GTP-binding protein Der; Reviewed; Region: PRK00093 418127004278 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 418127004279 G1 box; other site 418127004280 GTP/Mg2+ binding site [chemical binding]; other site 418127004281 Switch I region; other site 418127004282 G2 box; other site 418127004283 Switch II region; other site 418127004284 G3 box; other site 418127004285 G4 box; other site 418127004286 G5 box; other site 418127004287 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 418127004288 G1 box; other site 418127004289 GTP/Mg2+ binding site [chemical binding]; other site 418127004290 Switch I region; other site 418127004291 G2 box; other site 418127004292 G3 box; other site 418127004293 Switch II region; other site 418127004294 G4 box; other site 418127004295 G5 box; other site 418127004296 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 418127004297 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 418127004298 RNA binding site [nucleotide binding]; other site 418127004299 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 418127004300 RNA binding site [nucleotide binding]; other site 418127004301 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 418127004302 RNA binding site [nucleotide binding]; other site 418127004303 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 418127004304 RNA binding site [nucleotide binding]; other site 418127004305 similar to hypothetical protein 418127004306 cytidylate kinase; Provisional; Region: cmk; PRK00023 418127004307 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 418127004308 CMP-binding site; other site 418127004309 The sites determining sugar specificity; other site 418127004310 Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases, one highly specific for asparagine and localised to the...; Region: Asparaginase; cl00216 418127004311 active site/substrate binding site [active] 418127004312 tetramer interface [polypeptide binding]; other site 418127004313 putative bacillithiol system thiol disulfide oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 418127004314 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 418127004315 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 418127004316 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 418127004317 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 418127004318 ATP binding site [chemical binding]; other site 418127004319 putative Mg++ binding site [ion binding]; other site 418127004320 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 418127004321 nucleotide binding region [chemical binding]; other site 418127004322 ATP-binding site [chemical binding]; other site 418127004323 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 418127004324 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 418127004325 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 418127004326 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 418127004327 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 418127004328 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 418127004329 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 418127004330 V-type ATPase 116kDa subunit family; Region: V_ATPase_I; pfam01496 418127004331 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 418127004332 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 418127004333 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 418127004334 dimerization interface [polypeptide binding]; other site 418127004335 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 418127004336 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 418127004337 dimer interface [polypeptide binding]; other site 418127004338 phosphorylation site [posttranslational modification] 418127004339 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 418127004340 ATP binding site [chemical binding]; other site 418127004341 Mg2+ binding site [ion binding]; other site 418127004342 G-X-G motif; other site 418127004343 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 418127004344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 418127004345 active site 418127004346 phosphorylation site [posttranslational modification] 418127004347 intermolecular recognition site; other site 418127004348 dimerization interface [polypeptide binding]; other site 418127004349 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 418127004350 DNA binding site [nucleotide binding] 418127004351 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 418127004352 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 418127004353 RNA binding surface [nucleotide binding]; other site 418127004354 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 418127004355 active site 418127004356 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 418127004357 ScpA/B protein; Region: ScpA_ScpB; cl00598 418127004358 Domain of unknown function (DUF309); Region: DUF309; cl00667 418127004359 N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid...; Region: INT_XerDC; cd00798 418127004360 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 418127004361 Int/Topo IB signature motif; other site 418127004362 active site 418127004363 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 418127004364 metal binding site 2 [ion binding]; metal-binding site 418127004365 putative DNA binding helix; other site 418127004366 metal binding site 1 [ion binding]; metal-binding site 418127004367 dimer interface [polypeptide binding]; other site 418127004368 structural Zn2+ binding site [ion binding]; other site 418127004369 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 418127004370 dimer interface [polypeptide binding]; other site 418127004371 ADP-ribose binding site [chemical binding]; other site 418127004372 active site 418127004373 nudix motif; other site 418127004374 metal binding site [ion binding]; metal-binding site 418127004375 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 418127004376 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 418127004377 active site 418127004378 catalytic tetrad [active] 418127004379 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 418127004380 classical (c) SDRs; Region: SDR_c; cd05233 418127004381 NAD(P) binding site [chemical binding]; other site 418127004382 active site 418127004383 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127004384 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 418127004385 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 418127004386 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 418127004387 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 418127004388 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 418127004389 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 418127004390 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 418127004391 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 418127004392 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 418127004393 Transcriptional regulators [Transcription]; Region: PurR; COG1609 418127004394 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 418127004395 DNA binding site [nucleotide binding] 418127004396 domain linker motif; other site 418127004397 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 418127004398 putative ligand binding site [chemical binding]; other site 418127004399 putative dimerization interface [polypeptide binding]; other site 418127004400 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 418127004401 H+ Antiporter protein; Region: 2A0121; TIGR00900 418127004402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127004403 putative substrate translocation pore; other site 418127004404 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127004405 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 418127004406 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 418127004407 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 418127004408 peptidase T-like protein; Region: PepT-like; TIGR01883 418127004409 metal binding site [ion binding]; metal-binding site 418127004410 putative dimer interface [polypeptide binding]; other site 418127004411 Predicted membrane protein [Function unknown]; Region: COG4129 418127004412 Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136 418127004413 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 418127004414 Protein of unknown function (DUF1094); Region: DUF1094; pfam06491 418127004415 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 418127004416 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 418127004417 E3 interaction surface; other site 418127004418 lipoyl attachment site [posttranslational modification]; other site 418127004419 e3 binding domain; Region: E3_binding; pfam02817 418127004420 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 418127004421 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 418127004422 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 418127004423 alpha subunit interface [polypeptide binding]; other site 418127004424 TPP binding site [chemical binding]; other site 418127004425 heterodimer interface [polypeptide binding]; other site 418127004426 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 418127004427 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 418127004428 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 418127004429 tetramer interface [polypeptide binding]; other site 418127004430 TPP-binding site [chemical binding]; other site 418127004431 heterodimer interface [polypeptide binding]; other site 418127004432 phosphorylation loop region [posttranslational modification] 418127004433 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 418127004434 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 418127004435 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 418127004436 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 418127004437 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 418127004438 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 418127004439 Walker A/P-loop; other site 418127004440 ATP binding site [chemical binding]; other site 418127004441 Q-loop/lid; other site 418127004442 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 418127004443 Q-loop/lid; other site 418127004444 ABC transporter signature motif; other site 418127004445 Walker B; other site 418127004446 D-loop; other site 418127004447 H-loop/switch region; other site 418127004448 arginine repressor; Provisional; Region: PRK04280 418127004449 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 418127004450 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 418127004451 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 418127004452 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 418127004453 substrate binding pocket [chemical binding]; other site 418127004454 chain length determination region; other site 418127004455 substrate-Mg2+ binding site; other site 418127004456 catalytic residues [active] 418127004457 aspartate-rich region 1; other site 418127004458 active site lid residues [active] 418127004459 aspartate-rich region 2; other site 418127004460 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 418127004461 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 418127004462 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489 418127004463 generic binding surface II; other site 418127004464 generic binding surface I; other site 418127004465 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 418127004466 putative RNA binding site [nucleotide binding]; other site 418127004467 Protein of unknown function (DUF322); Region: DUF322; cl00574 418127004468 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 418127004469 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 418127004470 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 418127004471 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 418127004472 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 418127004473 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 418127004474 carboxyltransferase (CT) interaction site; other site 418127004475 biotinylation site [posttranslational modification]; other site 418127004476 elongation factor P; Validated; Region: PRK00529 418127004477 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 418127004478 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 418127004479 RNA binding site [nucleotide binding]; other site 418127004480 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 418127004481 RNA binding site [nucleotide binding]; other site 418127004482 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 418127004483 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 418127004484 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 418127004485 active site 418127004486 Axonemal dynein light chain; Region: Ax_dynein_light; pfam10211 418127004487 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 418127004488 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 418127004489 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 418127004490 active site residue [active] 418127004491 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 418127004492 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 418127004493 tetramer interface [polypeptide binding]; other site 418127004494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127004495 catalytic residue [active] 418127004496 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 418127004497 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 418127004498 tetramer interface [polypeptide binding]; other site 418127004499 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127004500 catalytic residue [active] 418127004501 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 418127004502 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 418127004503 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464 418127004504 ADP binding site [chemical binding]; other site 418127004505 magnesium binding site [ion binding]; other site 418127004506 putative shikimate binding site; other site 418127004507 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 418127004508 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 418127004509 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 418127004510 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 418127004511 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 418127004512 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 418127004513 Type II/IV secretion system protein; Region: GSPII_E; pfam00437 418127004514 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 418127004515 Walker A motif; other site 418127004516 ATP binding site [chemical binding]; other site 418127004517 Walker B motif; other site 418127004518 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 418127004519 Domain of unknown function DUF77; Region: DUF77; cl00307 418127004520 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 418127004521 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 418127004522 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 418127004523 Rhomboid family; Region: Rhomboid; cl11446 418127004524 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 418127004525 binding surface 418127004526 TPR motif; other site 418127004527 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 418127004528 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 418127004529 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 418127004530 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 418127004531 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 418127004532 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 418127004533 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 418127004534 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 418127004535 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 418127004536 metal binding site 2 [ion binding]; metal-binding site 418127004537 putative DNA binding helix; other site 418127004538 metal binding site 1 [ion binding]; metal-binding site 418127004539 dimer interface [polypeptide binding]; other site 418127004540 structural Zn2+ binding site [ion binding]; other site 418127004541 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 418127004542 ABC-ATPase subunit interface; other site 418127004543 dimer interface [polypeptide binding]; other site 418127004544 putative PBP binding regions; other site 418127004545 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 418127004546 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 418127004547 endonuclease IV; Provisional; Region: PRK01060 418127004548 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cd00019 418127004549 AP (apurinic/apyrimidinic) site pocket; other site 418127004550 DNA interaction; other site 418127004551 Metal-binding active site; metal-binding site 418127004552 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 418127004553 DEAD-like helicases superfamily; Region: DEXDc; smart00487 418127004554 ATP binding site [chemical binding]; other site 418127004555 Mg++ binding site [ion binding]; other site 418127004556 motif III; other site 418127004557 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 418127004558 nucleotide binding region [chemical binding]; other site 418127004559 ATP-binding site [chemical binding]; other site 418127004560 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309 418127004561 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309 418127004562 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309 418127004563 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 418127004564 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 418127004565 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 418127004566 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 418127004567 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 418127004568 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 418127004569 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 418127004570 DNA binding residues [nucleotide binding] 418127004571 DNA primase, catalytic core; Region: dnaG; TIGR01391 418127004572 CHC2 zinc finger; Region: zf-CHC2; cl02597 418127004573 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 418127004574 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 418127004575 active site 418127004576 metal binding site [ion binding]; metal-binding site 418127004577 interdomain interaction site; other site 418127004578 Domain of unknown function (DUF299); Region: DUF299; cl00780 418127004579 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127004580 FOG: CBS domain [General function prediction only]; Region: COG0517 418127004581 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_4; cd04617 418127004582 glycyl-tRNA synthetase; Provisional; Region: PRK04173 418127004583 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 418127004584 motif 1; other site 418127004585 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the...; Region: GlyRS-like_core; cd00774 418127004586 active site 418127004587 motif 2; other site 418127004588 motif 3; other site 418127004589 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 418127004590 anticodon binding site; other site 418127004591 DNA repair protein RecO; Region: reco; TIGR00613 418127004592 Recombination protein O N terminal; Region: RecO_N; pfam11967 418127004593 Recombination protein O C terminal; Region: RecO_C; pfam02565 418127004594 GTPase Era; Reviewed; Region: era; PRK00089 418127004595 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 418127004596 G1 box; other site 418127004597 GTP/Mg2+ binding site [chemical binding]; other site 418127004598 Switch I region; other site 418127004599 G2 box; other site 418127004600 Switch II region; other site 418127004601 G3 box; other site 418127004602 G4 box; other site 418127004603 G5 box; other site 418127004604 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 418127004605 active site 418127004606 catalytic motif [active] 418127004607 Zn binding site [ion binding]; other site 418127004608 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 418127004609 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 418127004610 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 418127004611 PhoH-like protein; Region: PhoH; cl12134 418127004612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4864 418127004613 SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057 418127004614 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 418127004615 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 418127004616 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 418127004617 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 418127004618 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 418127004619 FeS/SAM binding site; other site 418127004620 TRAM domain; Region: TRAM; cl01282 418127004621 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 418127004622 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 418127004623 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 418127004624 S-adenosylmethionine binding site [chemical binding]; other site 418127004625 chaperone protein DnaJ; Provisional; Region: PRK14280 418127004626 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 418127004627 HSP70 interaction site [polypeptide binding]; other site 418127004628 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 418127004629 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 418127004630 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 418127004631 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 418127004632 heat shock protein GrpE; Provisional; Region: PRK14140 418127004633 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 418127004634 dimer interface [polypeptide binding]; other site 418127004635 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 418127004636 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 418127004637 HrcA protein C terminal domain; Region: HrcA; pfam01628 418127004638 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 418127004639 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 418127004640 HemN C-terminal region; Region: HemN_C; pfam06969 418127004641 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 418127004642 GTP-binding protein LepA; Provisional; Region: PRK05433 418127004643 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 418127004644 G1 box; other site 418127004645 putative GEF interaction site [polypeptide binding]; other site 418127004646 GTP/Mg2+ binding site [chemical binding]; other site 418127004647 Switch I region; other site 418127004648 G2 box; other site 418127004649 G3 box; other site 418127004650 Switch II region; other site 418127004651 G4 box; other site 418127004652 G5 box; other site 418127004653 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699 418127004654 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 418127004655 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 418127004656 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 418127004657 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 418127004658 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 418127004659 Competence protein; Region: Competence; cl00471 418127004660 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 418127004661 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 418127004662 catalytic motif [active] 418127004663 Zn binding site [ion binding]; other site 418127004664 comEA protein; Region: comE; TIGR01259 418127004665 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 418127004666 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 418127004667 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 418127004668 S-adenosylmethionine binding site [chemical binding]; other site 418127004669 Domain of unknown function DUF143; Region: DUF143; cl00519 418127004670 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 418127004671 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 418127004672 Zn2+ binding site [ion binding]; other site 418127004673 Mg2+ binding site [ion binding]; other site 418127004674 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 418127004675 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 418127004676 active site 418127004677 (T/H)XGH motif; other site 418127004678 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 418127004679 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 418127004680 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 418127004681 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 418127004682 shikimate binding site; other site 418127004683 NAD(P) binding site [chemical binding]; other site 418127004684 GTPase YqeH; Provisional; Region: PRK13796 418127004685 YqeH. YqeH is an essential GTP-binding protein. Depletion of YqeH induces an excess initiation of DNA replication, suggesting that it negatively controls initiation of chromosome replication. The YqeH subfamily is common in eukaryotes and sporadically...; Region: YqeH; cd01855 418127004686 GTP/Mg2+ binding site [chemical binding]; other site 418127004687 G4 box; other site 418127004688 G5 box; other site 418127004689 G1 box; other site 418127004690 Switch I region; other site 418127004691 G2 box; other site 418127004692 G3 box; other site 418127004693 Switch II region; other site 418127004694 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 418127004695 active site 418127004696 motif I; other site 418127004697 motif II; other site 418127004698 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 418127004699 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127004700 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 418127004701 Fic family protein [Function unknown]; Region: COG3177 418127004702 Fic/DOC family; Region: Fic; cl00960 418127004703 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 418127004704 LamB/YcsF family; Region: LamB_YcsF; cl00664 418127004705 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 418127004706 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 418127004707 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 418127004708 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 418127004709 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 418127004710 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 418127004711 carboxyltransferase (CT) interaction site; other site 418127004712 biotinylation site [posttranslational modification]; other site 418127004713 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 418127004714 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 418127004715 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 418127004716 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 418127004717 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 418127004718 domain; Region: GreA_GreB_N; pfam03449 418127004719 C-term; Region: GreA_GreB; pfam01272 418127004720 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage...; Region: UMPK; cd02023 418127004721 Sugar specificity; other site 418127004722 Pyrimidine base specificity; other site 418127004723 ATP-binding site [chemical binding]; other site 418127004724 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 418127004725 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 418127004726 Peptidase family U32; Region: Peptidase_U32; cl03113 418127004727 Peptidase family U32; Region: Peptidase_U32; cl03113 418127004728 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 418127004729 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 418127004730 S-adenosylmethionine binding site [chemical binding]; other site 418127004731 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 418127004732 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 418127004733 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 418127004734 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 418127004735 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 418127004736 motif 1; other site 418127004737 active site 418127004738 motif 2; other site 418127004739 motif 3; other site 418127004740 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 418127004741 DHHA1 domain; Region: DHHA1; pfam02272 418127004742 RecD/TraA family; Region: recD_rel; TIGR01448 418127004743 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 418127004744 binding surface 418127004745 TPR motif; other site 418127004746 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 418127004747 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 418127004748 binding surface 418127004749 TPR motif; other site 418127004750 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 418127004751 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 418127004752 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 418127004753 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 418127004754 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 418127004755 catalytic residue [active] 418127004756 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 418127004757 CsbD-like; Region: CsbD; cl01272 418127004758 Predicted transcriptional regulator [Transcription]; Region: COG1959 418127004759 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127004760 recombination factor protein RarA; Reviewed; Region: PRK13342 418127004761 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 418127004762 Walker A motif; other site 418127004763 ATP binding site [chemical binding]; other site 418127004764 Walker B motif; other site 418127004765 arginine finger; other site 418127004766 MgsA AAA+ ATPase C terminal; Region: MgsA_C; cl13440 418127004767 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 418127004768 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-...; Region: YgdL_like; cd00755 418127004769 putative ATP binding site [chemical binding]; other site 418127004770 putative substrate interface [chemical binding]; other site 418127004771 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 418127004772 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 418127004773 dimer interface [polypeptide binding]; other site 418127004774 anticodon binding site; other site 418127004775 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 418127004776 homodimer interface [polypeptide binding]; other site 418127004777 motif 1; other site 418127004778 active site 418127004779 motif 2; other site 418127004780 GAD domain; Region: GAD; pfam02938 418127004781 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 418127004782 motif 3; other site 418127004783 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 418127004784 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 418127004785 dimer interface [polypeptide binding]; other site 418127004786 motif 1; other site 418127004787 active site 418127004788 motif 2; other site 418127004789 motif 3; other site 418127004790 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 418127004791 anticodon binding site; other site 418127004792 Bacterial SH3 domain; Region: SH3_3; cl02551 418127004793 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 418127004794 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 418127004795 active site 418127004796 metal binding site [ion binding]; metal-binding site 418127004797 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but...; Region: Dtyr_deacylase; cd00563 418127004798 putative active site [active] 418127004799 dimerization interface [polypeptide binding]; other site 418127004800 putative tRNAtyr binding site [nucleotide binding]; other site 418127004801 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 418127004802 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 418127004803 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 418127004804 synthetase active site [active] 418127004805 NTP binding site [chemical binding]; other site 418127004806 metal binding site [ion binding]; metal-binding site 418127004807 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 418127004808 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 418127004809 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 418127004810 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 418127004811 DHH family; Region: DHH; pfam01368 418127004812 DHHA1 domain; Region: DHHA1; pfam02272 418127004813 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 418127004814 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 418127004815 Protein export membrane protein; Region: SecD_SecF; cl14618 418127004816 Protein export membrane protein; Region: SecD_SecF; cl14618 418127004817 Preprotein translocase subunit; Region: YajC; cl00806 418127004818 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 418127004819 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 418127004820 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 418127004821 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 418127004822 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 418127004823 Walker A motif; other site 418127004824 ATP binding site [chemical binding]; other site 418127004825 Walker B motif; other site 418127004826 arginine finger; other site 418127004827 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 418127004828 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 418127004829 RuvA N terminal domain; Region: RuvA_N; pfam01330 418127004830 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 418127004831 hypothetical protein; Provisional; Region: PRK04435 418127004832 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 418127004833 GTPase CgtA; Reviewed; Region: obgE; PRK12297 418127004834 GTP1/OBG; Region: GTP1_OBG; pfam01018 418127004835 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 418127004836 G1 box; other site 418127004837 GTP/Mg2+ binding site [chemical binding]; other site 418127004838 Switch I region; other site 418127004839 G2 box; other site 418127004840 G3 box; other site 418127004841 Switch II region; other site 418127004842 G4 box; other site 418127004843 G5 box; other site 418127004844 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 418127004845 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 418127004846 Protein of unknown function (DUF464); Region: DUF464; cl01080 418127004847 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 418127004848 rod shape-determining protein MreD; Region: MreD; cl01087 418127004849 rod shape-determining protein MreC; Provisional; Region: PRK13922 418127004850 rod shape-determining protein MreC; Region: MreC; pfam04085 418127004851 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 418127004852 S-adenosylmethionine binding site [chemical binding]; other site 418127004853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 418127004854 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 418127004855 active site 418127004856 NTP binding site [chemical binding]; other site 418127004857 metal binding triad [ion binding]; metal-binding site 418127004858 antibiotic binding site [chemical binding]; other site 418127004859 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 418127004860 Tn544B and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes various bacterial transposases similar to TnpB from transposon Tn554; Region: INT_Tn544B_C; cd01195 418127004861 Phage integrase family; Region: Phage_integrase; pfam00589 418127004862 Int/Topo IB signature motif; other site 418127004863 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 418127004864 Phage integrase family; Region: Phage_integrase; pfam00589 418127004865 Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194 418127004866 Int/Topo IB signature motif; other site 418127004867 hypothetical protein; Reviewed; Region: PRK00024 418127004868 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 418127004869 MPN+ (JAMM) motif; other site 418127004870 Zinc-binding site [ion binding]; other site 418127004871 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 418127004872 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 418127004873 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 418127004874 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 418127004875 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 418127004876 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 418127004877 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 418127004878 active site 418127004879 HIGH motif; other site 418127004880 nucleotide binding site [chemical binding]; other site 418127004881 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 418127004882 active site 418127004883 KMSKS motif; other site 418127004884 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 418127004885 tRNA binding surface [nucleotide binding]; other site 418127004886 anticodon binding site; other site 418127004887 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 418127004888 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 418127004889 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 418127004890 Putative ammonia monooxygenase; Region: AmoA; pfam05145 418127004891 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 418127004892 similar to hypothetical protein 418127004893 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 418127004894 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 418127004895 inhibitor-cofactor binding pocket; inhibition site 418127004896 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127004897 catalytic residue [active] 418127004898 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 418127004899 dimer interface [polypeptide binding]; other site 418127004900 active site 418127004901 Schiff base residues; other site 418127004902 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 418127004903 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 418127004904 active site 418127004905 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 418127004906 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 418127004907 domain interfaces; other site 418127004908 active site 418127004909 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 418127004910 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 418127004911 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 418127004912 tRNA; other site 418127004913 putative tRNA binding site [nucleotide binding]; other site 418127004914 putative NADP binding site [chemical binding]; other site 418127004915 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 418127004916 The YihA (EngB) subfamily. This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876 418127004917 G1 box; other site 418127004918 GTP/Mg2+ binding site [chemical binding]; other site 418127004919 Switch I region; other site 418127004920 G2 box; other site 418127004921 G3 box; other site 418127004922 Switch II region; other site 418127004923 G4 box; other site 418127004924 G5 box; other site 418127004925 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 418127004926 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 418127004927 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 418127004928 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 418127004929 trigger factor; Provisional; Region: tig; PRK01490 418127004930 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 418127004931 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 418127004932 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 418127004933 nudix motif; other site 418127004934 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 418127004935 23S rRNA binding site [nucleotide binding]; other site 418127004936 L21 binding site [polypeptide binding]; other site 418127004937 L13 binding site [polypeptide binding]; other site 418127004938 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 418127004939 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 418127004940 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 418127004941 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 418127004942 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 418127004943 Amino acid permease; Region: AA_permease; pfam00324 418127004944 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 418127004945 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase...; Region: TGS_ThrRS_N; cd01667 418127004946 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 418127004947 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 418127004948 active site 418127004949 dimer interface [polypeptide binding]; other site 418127004950 motif 1; other site 418127004951 motif 2; other site 418127004952 motif 3; other site 418127004953 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 418127004954 anticodon binding site; other site 418127004955 primosomal protein DnaI; Reviewed; Region: PRK08939 418127004956 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 418127004957 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 418127004958 Walker A motif; other site 418127004959 ATP binding site [chemical binding]; other site 418127004960 Walker B motif; other site 418127004961 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 418127004962 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 418127004963 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 418127004964 ATP cone domain; Region: ATP-cone; pfam03477 418127004965 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 418127004966 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127004967 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 418127004968 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 418127004969 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 418127004970 CoA-binding site [chemical binding]; other site 418127004971 ATP-binding [chemical binding]; other site 418127004972 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 418127004973 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 418127004974 DNA binding site [nucleotide binding] 418127004975 catalytic residue [active] 418127004976 H2TH interface [polypeptide binding]; other site 418127004977 putative catalytic residues [active] 418127004978 turnover-facilitating residue; other site 418127004979 intercalation triad [nucleotide binding]; other site 418127004980 8OG recognition residue [nucleotide binding]; other site 418127004981 putative reading head residues; other site 418127004982 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 418127004983 DNA polymerase I; Provisional; Region: PRK05755 418127004984 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 418127004985 active site 418127004986 metal binding site 1 [ion binding]; metal-binding site 418127004987 putative 5' ssDNA interaction site; other site 418127004988 metal binding site 3; metal-binding site 418127004989 metal binding site 2 [ion binding]; metal-binding site 418127004990 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 418127004991 putative DNA binding site [nucleotide binding]; other site 418127004992 putative metal binding site [ion binding]; other site 418127004993 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 418127004994 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 418127004995 active site 418127004996 DNA binding site [nucleotide binding] 418127004997 catalytic site [active] 418127004998 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 418127004999 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 418127005000 dimer interface [polypeptide binding]; other site 418127005001 phosphorylation site [posttranslational modification] 418127005002 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 418127005003 ATP binding site [chemical binding]; other site 418127005004 Mg2+ binding site [ion binding]; other site 418127005005 G-X-G motif; other site 418127005006 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 418127005007 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 418127005008 active site 418127005009 phosphorylation site [posttranslational modification] 418127005010 intermolecular recognition site; other site 418127005011 dimerization interface [polypeptide binding]; other site 418127005012 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 418127005013 DNA binding site [nucleotide binding] 418127005014 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 418127005015 isocitrate dehydrogenase; Validated; Region: PRK07362 418127005016 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes...; Region: BSuCS-II_like; cd06110 418127005017 dimer interface [polypeptide binding]; other site 418127005018 Citrate synthase; Region: Citrate_synt; pfam00285 418127005019 active site 418127005020 citrylCoA binding site [chemical binding]; other site 418127005021 oxalacetate/citrate binding site [chemical binding]; other site 418127005022 coenzyme A binding site [chemical binding]; other site 418127005023 catalytic triad [active] 418127005024 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 418127005025 pyruvate kinase; Provisional; Region: PRK06354 418127005026 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 418127005027 domain interfaces; other site 418127005028 active site 418127005029 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 418127005030 6-phosphofructokinase; Provisional; Region: PRK03202 418127005031 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204 418127005032 dimerization interface [polypeptide binding]; other site 418127005033 allosteric effector site; other site 418127005034 active site 418127005035 ADP/pyrophosphate binding site [chemical binding]; other site 418127005036 fructose-1,6-bisphosphate binding site; other site 418127005037 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 418127005038 Transposase; Region: DDE_Tnp_ISL3; pfam01610 418127005039 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 418127005040 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 418127005041 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 418127005042 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 418127005043 Malic enzyme, N-terminal domain; Region: malic; pfam00390 418127005044 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 418127005045 putative NAD(P) binding site [chemical binding]; other site 418127005046 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 418127005047 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 418127005048 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 418127005049 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 418127005050 generic binding surface I; other site 418127005051 generic binding surface II; other site 418127005052 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 418127005053 DHH family; Region: DHH; pfam01368 418127005054 DHHA1 domain; Region: DHHA1; pfam02272 418127005055 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 418127005056 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127005057 DNA-binding site [nucleotide binding]; DNA binding site 418127005058 DRTGG domain; Region: DRTGG; cl12147 418127005059 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 418127005060 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 418127005061 Ligand Binding Site [chemical binding]; other site 418127005062 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 418127005063 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 418127005064 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 418127005065 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 418127005066 active site 418127005067 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 418127005068 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 418127005069 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127005070 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 418127005071 Ligand Binding Site [chemical binding]; other site 418127005072 Acetokinase family; Region: Acetate_kinase; cl01029 418127005073 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 418127005074 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 418127005075 dimer interface [polypeptide binding]; other site 418127005076 catalytic triad [active] 418127005077 peroxidatic and resolving cysteines [active] 418127005078 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 418127005079 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 418127005080 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 418127005081 THUMP domain; Region: THUMP; cl12076 418127005082 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 418127005083 Ligand Binding Site [chemical binding]; other site 418127005084 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 418127005085 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 418127005086 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 418127005087 catalytic residue [active] 418127005088 septation ring formation regulator EzrA; Provisional; Region: PRK04778 418127005089 GAF domain; Region: GAF; cl00853 418127005090 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 418127005091 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 418127005092 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 418127005093 RNA binding surface [nucleotide binding]; other site 418127005094 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 418127005095 Transposase; Region: DDE_Tnp_ISL3; pfam01610 418127005096 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 418127005097 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 418127005098 active site 418127005099 catalytic site [active] 418127005100 OsmC-like protein; Region: OsmC; cl00767 418127005101 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 418127005102 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 418127005103 catalytic residue [active] 418127005104 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 418127005105 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127005106 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 418127005107 putative L-serine binding site [chemical binding]; other site 418127005108 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 418127005109 motif II; other site 418127005110 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 418127005111 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 418127005112 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 418127005113 active site turn [active] 418127005114 phosphorylation site [posttranslational modification] 418127005115 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 418127005116 putative acyl-acceptor binding pocket; other site 418127005117 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 418127005118 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 418127005119 protein binding site [polypeptide binding]; other site 418127005120 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 418127005121 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 418127005122 active site 418127005123 HIGH motif; other site 418127005124 dimer interface [polypeptide binding]; other site 418127005125 KMSKS motif; other site 418127005126 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 418127005127 RNA binding surface [nucleotide binding]; other site 418127005128 Transglycosylase; Region: Transgly; cl07896 418127005129 haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658 418127005130 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 418127005131 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cl02760 418127005132 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cl02760 418127005133 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 418127005134 heme-binding site [chemical binding]; other site 418127005135 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 418127005136 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 418127005137 Potassium binding sites [ion binding]; other site 418127005138 Cesium cation binding sites [ion binding]; other site 418127005139 acetyl-CoA synthetase; Provisional; Region: PRK04319 418127005140 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 418127005141 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 418127005142 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 418127005143 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 418127005144 catabolite control protein A; Region: ccpA; TIGR01481 418127005145 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 418127005146 DNA binding site [nucleotide binding] 418127005147 domain linker motif; other site 418127005148 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 418127005149 dimerization interface [polypeptide binding]; other site 418127005150 effector binding site; other site 418127005151 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 418127005152 Chorismate mutase type II; Region: CM_2; cl00693 418127005153 NeuB family; Region: NeuB; cl00496 418127005154 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 418127005155 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 418127005156 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 418127005157 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 418127005158 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 418127005159 Ring-infected erythrocyte surface antigen; Provisional; Region: PTZ00341 418127005160 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 418127005161 HerA helicase [Replication, recombination, and repair]; Region: COG0433 418127005162 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 418127005163 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 418127005164 putative tRNA-binding site [nucleotide binding]; other site 418127005165 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 418127005166 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 418127005167 catalytic residues [active] 418127005168 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 418127005169 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 418127005170 oligomer interface [polypeptide binding]; other site 418127005171 active site 418127005172 metal binding site [ion binding]; metal-binding site 418127005173 Predicted small secreted protein [Function unknown]; Region: COG5584 418127005174 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 418127005175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 418127005176 Phosphotransferase enzyme family; Region: APH; pfam01636 418127005177 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 418127005178 substrate binding site [chemical binding]; other site 418127005179 branched-chain amino acid aminotransferase; Provisional; Region: PRK12479 418127005180 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and D-...; Region: D-AAT_like; cd01558 418127005181 homodimer interface [polypeptide binding]; other site 418127005182 substrate-cofactor binding pocket; other site 418127005183 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127005184 catalytic residue [active] 418127005185 dipeptidase PepV; Reviewed; Region: PRK07318 418127005186 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 418127005187 active site 418127005188 metal binding site [ion binding]; metal-binding site 418127005189 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 418127005190 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 418127005191 RNA binding surface [nucleotide binding]; other site 418127005192 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 418127005193 active site 418127005194 uracil binding [chemical binding]; other site 418127005195 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 418127005196 stage V sporulation protein B; Region: spore_V_B; TIGR02900 418127005197 MatE; Region: MatE; pfam01554 418127005198 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 418127005199 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 418127005200 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 418127005201 cytoskeletal protein RodZ; Provisional; Region: PRK10856 418127005202 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127005203 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127005204 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127005205 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127005206 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127005207 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127005208 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127005209 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127005210 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127005211 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127005212 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127005213 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127005214 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127005215 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127005216 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127005217 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 418127005218 active site residue [active] 418127005219 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 418127005220 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 418127005221 HIGH motif; other site 418127005222 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 418127005223 active site 418127005224 KMSKS motif; other site 418127005225 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 418127005226 tRNA binding surface [nucleotide binding]; other site 418127005227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127005228 Major Facilitator Superfamily; Region: MFS_1; pfam07690 418127005229 putative substrate translocation pore; other site 418127005230 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 418127005231 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 418127005232 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 418127005233 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 418127005234 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127005235 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 418127005236 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 418127005237 Proline dehydrogenase; Region: Pro_dh; cl03282 418127005238 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 418127005239 homopentamer interface [polypeptide binding]; other site 418127005240 active site 418127005241 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 418127005242 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 418127005243 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 418127005244 dimerization interface [polypeptide binding]; other site 418127005245 active site 418127005246 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 418127005247 Lumazine binding domain; Region: Lum_binding; pfam00677 418127005248 Lumazine binding domain; Region: Lum_binding; pfam00677 418127005249 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 418127005250 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 418127005251 catalytic motif [active] 418127005252 Zn binding site [ion binding]; other site 418127005253 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 418127005254 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 418127005255 hypothetical protein; Provisional; Region: PRK09897 418127005256 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 418127005257 dimerization interface [polypeptide binding]; other site 418127005258 putative DNA binding site [nucleotide binding]; other site 418127005259 putative Zn2+ binding site [ion binding]; other site 418127005260 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 418127005261 arsenical pump membrane protein; Provisional; Region: PRK15445 418127005262 transmembrane helices; other site 418127005263 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 418127005264 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 418127005265 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 418127005266 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cl10457 418127005267 DNA binding residues [nucleotide binding] 418127005268 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 418127005269 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 418127005270 active site 418127005271 intersubunit interactions; other site 418127005272 catalytic residue [active] 418127005273 CrcB-like protein; Region: CRCB; cl09114 418127005274 CrcB-like protein; Region: CRCB; cl09114 418127005275 Transposase domain (DUF772); Region: DUF772; cl12084 418127005276 Transposase domain (DUF772); Region: DUF772; cl12084 418127005277 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 418127005278 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 418127005279 active site 418127005280 catalytic tetrad [active] 418127005281 S-adenosylmethionine synthetase; Validated; Region: PRK05250 418127005282 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 418127005283 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 418127005284 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 418127005285 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 418127005286 active site 418127005287 substrate-binding site [chemical binding]; other site 418127005288 metal-binding site [ion binding] 418127005289 ATP binding site [chemical binding]; other site 418127005290 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 418127005291 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 418127005292 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 418127005293 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 418127005294 nudix motif; other site 418127005295 Domain of unknown function DUF37; Region: DUF37; cl00506 418127005296 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion...; Region: enolase_like; cl14814 418127005297 o-succinylbenzoic acid (OSB) synthetase; Region: menC_lowGC/arch; TIGR01928 418127005298 metal binding site [ion binding]; metal-binding site 418127005299 substrate binding pocket [chemical binding]; other site 418127005300 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 418127005301 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 418127005302 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 418127005303 Telomeric repeat-binding factor 2; Region: TRF2; pfam11611 418127005304 Integrase core domain; Region: rve; cl01316 418127005305 putative transposase OrfB; Reviewed; Region: PHA02517 418127005306 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 418127005307 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 418127005308 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 418127005309 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 418127005310 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 418127005311 HsdM N-terminal domain; Region: HsdM_N; pfam12161 418127005312 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 418127005313 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 418127005314 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 418127005315 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 418127005316 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 418127005317 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 418127005318 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 418127005319 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 418127005320 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 418127005321 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 418127005322 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 418127005323 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 418127005324 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 418127005325 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 418127005326 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 418127005327 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127005328 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 418127005329 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127005330 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127005331 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 418127005332 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 418127005333 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127005334 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 418127005335 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127005336 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 418127005337 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127005338 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 418127005339 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 418127005340 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 418127005341 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 418127005342 ferrochelatase; Provisional; Region: PRK12435 418127005343 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 418127005344 C-terminal domain interface [polypeptide binding]; other site 418127005345 active site 418127005346 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 418127005347 active site 418127005348 N-terminal domain interface [polypeptide binding]; other site 418127005349 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This...; Region: URO-D; cd00717 418127005350 substrate binding site [chemical binding]; other site 418127005351 active site 418127005352 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 418127005353 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 418127005354 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 418127005355 Walker A/P-loop; other site 418127005356 ATP binding site [chemical binding]; other site 418127005357 Q-loop/lid; other site 418127005358 ABC transporter signature motif; other site 418127005359 Walker B; other site 418127005360 D-loop; other site 418127005361 H-loop/switch region; other site 418127005362 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life...; Region: HINT_subgroup; cd01277 418127005363 HIT family signature motif; other site 418127005364 catalytic residue [active] 418127005365 YtxH-like protein; Region: YtxH; cl02079 418127005366 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 418127005367 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 418127005368 PPIC-type PPIASE domain; Region: Rotamase; cl08278 418127005369 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 418127005370 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 418127005371 generic binding surface II; other site 418127005372 generic binding surface I; other site 418127005373 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 418127005374 Zn2+ binding site [ion binding]; other site 418127005375 Mg2+ binding site [ion binding]; other site 418127005376 Uncharacterized conserved protein [Function unknown]; Region: COG4717 418127005377 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 418127005378 Walker A/P-loop; other site 418127005379 ATP binding site [chemical binding]; other site 418127005380 Plant specific eukaryotic initiation factor 4B; Region: eIF-4B; pfam06273 418127005381 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 418127005382 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 418127005383 active site 418127005384 metal binding site [ion binding]; metal-binding site 418127005385 DNA binding site [nucleotide binding] 418127005386 Protein of unknown function (DUF964); Region: DUF964; cl01483 418127005387 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 418127005388 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 418127005389 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 418127005390 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 418127005391 active site 418127005392 phosphorylation site [posttranslational modification] 418127005393 intermolecular recognition site; other site 418127005394 dimerization interface [polypeptide binding]; other site 418127005395 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 418127005396 DNA binding residues [nucleotide binding] 418127005397 dimerization interface [polypeptide binding]; other site 418127005398 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 418127005399 GAF domain; Region: GAF; cl00853 418127005400 Histidine kinase; Region: HisKA_3; pfam07730 418127005401 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 418127005402 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 418127005403 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 418127005404 active site 418127005405 fumarate hydratase; Reviewed; Region: fumC; PRK00485 418127005406 Class II fumarases; Region: Fumarase_classII; cd01362 418127005407 active site 418127005408 tetramer interface [polypeptide binding]; other site 418127005409 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 418127005410 active site 418127005411 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 418127005412 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 418127005413 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 418127005414 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 418127005415 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 418127005416 Walker A/P-loop; other site 418127005417 ATP binding site [chemical binding]; other site 418127005418 Q-loop/lid; other site 418127005419 ABC transporter signature motif; other site 418127005420 Walker B; other site 418127005421 D-loop; other site 418127005422 H-loop/switch region; other site 418127005423 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 418127005424 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 418127005425 substrate binding pocket [chemical binding]; other site 418127005426 membrane-bound complex binding site; other site 418127005427 hinge residues; other site 418127005428 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 418127005429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 418127005430 dimer interface [polypeptide binding]; other site 418127005431 conserved gate region; other site 418127005432 putative PBP binding loops; other site 418127005433 ABC-ATPase subunit interface; other site 418127005434 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 418127005435 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 418127005436 Transposase; Region: DDE_Tnp_ISL3; pfam01610 418127005437 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 418127005438 metal binding site 2 [ion binding]; metal-binding site 418127005439 putative DNA binding helix; other site 418127005440 metal binding site 1 [ion binding]; metal-binding site 418127005441 dimer interface [polypeptide binding]; other site 418127005442 structural Zn2+ binding site [ion binding]; other site 418127005443 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 418127005444 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127005445 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 418127005446 catalytic triad [active] 418127005447 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 418127005448 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 418127005449 inhibitor-cofactor binding pocket; inhibition site 418127005450 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127005451 catalytic residue [active] 418127005452 Predicted membrane protein [Function unknown]; Region: COG4129 418127005453 Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136 418127005454 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 418127005455 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 418127005456 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 418127005457 Walker A/P-loop; other site 418127005458 ATP binding site [chemical binding]; other site 418127005459 Q-loop/lid; other site 418127005460 ABC transporter signature motif; other site 418127005461 Walker B; other site 418127005462 D-loop; other site 418127005463 H-loop/switch region; other site 418127005464 Protein of unknown function (DUF402); Region: DUF402; cl00979 418127005465 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 418127005466 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 418127005467 minor groove reading motif; other site 418127005468 helix-hairpin-helix signature motif; other site 418127005469 substrate binding pocket [chemical binding]; other site 418127005470 active site 418127005471 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 418127005472 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 418127005473 DNA binding and oxoG recognition site [nucleotide binding] 418127005474 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 418127005475 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 418127005476 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 418127005477 Walker A/P-loop; other site 418127005478 ATP binding site [chemical binding]; other site 418127005479 Q-loop/lid; other site 418127005480 ABC transporter signature motif; other site 418127005481 Walker B; other site 418127005482 D-loop; other site 418127005483 H-loop/switch region; other site 418127005484 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 418127005485 RecX family; Region: RecX; cl00936 418127005486 Transglycosylase; Region: Transgly; cl07896 418127005487 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 418127005488 proposed catalytic triad [active] 418127005489 conserved cys residue [active] 418127005490 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 418127005491 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 418127005492 YfkB-like domain; Region: YfkB; pfam08756 418127005493 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain...; Region: BFIT_BACH; cd03442 418127005494 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 418127005495 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 418127005496 Low molecular weight phosphatase family; Region: LMWPc; cd00115 418127005497 Active site [active] 418127005498 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 418127005499 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 418127005500 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 418127005501 active site 418127005502 phosphorylation site [posttranslational modification] 418127005503 intermolecular recognition site; other site 418127005504 dimerization interface [polypeptide binding]; other site 418127005505 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 418127005506 DNA binding residues [nucleotide binding] 418127005507 dimerization interface [polypeptide binding]; other site 418127005508 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 418127005509 Histidine kinase; Region: HisKA_3; pfam07730 418127005510 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 418127005511 ATP binding site [chemical binding]; other site 418127005512 Mg2+ binding site [ion binding]; other site 418127005513 G-X-G motif; other site 418127005514 Predicted membrane protein (DUF2154); Region: DUF2154; cl12089 418127005515 methionine aminopeptidase; Reviewed; Region: PRK07281 418127005516 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 418127005517 active site 418127005518 Predicted membrane protein [Function unknown]; Region: COG4129 418127005519 Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136 418127005520 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 418127005521 catalytic triad [active] 418127005522 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 418127005523 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 418127005524 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 418127005525 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 418127005526 Ferritin-like domain; Region: Ferritin; pfam00210 418127005527 ferroxidase diiron center [ion binding]; other site 418127005528 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 418127005529 active site 418127005530 substrate binding site [chemical binding]; other site 418127005531 catalytic site [active] 418127005532 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 418127005533 active site 418127005534 DNA polymerase IV; Validated; Region: PRK02406 418127005535 DNA binding site [nucleotide binding] 418127005536 TRAM domain; Region: TRAM; cl01282 418127005537 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 418127005538 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 418127005539 S-adenosylmethionine binding site [chemical binding]; other site 418127005540 putative lipid kinase; Reviewed; Region: PRK13337 418127005541 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 418127005542 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 418127005543 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 418127005544 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 418127005545 GatB domain; Region: GatB_Yqey; cl11497 418127005546 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 418127005547 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 418127005548 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 418127005549 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 418127005550 Sodium:solute symporter family; Region: SSF; cl00456 418127005551 CamS sex pheromone cAM373 precursor; Region: CamS; cl11554 418127005552 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 418127005553 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 418127005554 nucleotide binding pocket [chemical binding]; other site 418127005555 K-X-D-G motif; other site 418127005556 catalytic site [active] 418127005557 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 418127005558 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 418127005559 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 418127005560 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027 418127005561 Dimer interface [polypeptide binding]; other site 418127005562 BRCT sequence motif; other site 418127005563 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 418127005564 UvrD/REP helicase; Region: UvrD-helicase; cl14126 418127005565 Predicted phosphate-binding enzymes, TIM-barrel fold [General function prediction only]; Region: COG1646 418127005566 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between sn-glycerol-1-...; Region: PcrB_like; cd02812 418127005567 substrate binding site [chemical binding]; other site 418127005568 putative active site [active] 418127005569 dimer interface [polypeptide binding]; other site 418127005570 Trp repressor protein; Region: Trp_repressor; cl01121 418127005571 adenylosuccinate lyase; Provisional; Region: PRK07492 418127005572 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 418127005573 tetramer interface [polypeptide binding]; other site 418127005574 active site 418127005575 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 418127005576 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 418127005577 Staphostatin A; Region: Staphostatin_A; pfam09022 418127005578 hypothetical protein; Provisional; Region: PRK04164 418127005579 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 418127005580 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 418127005581 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 418127005582 homodimer interface [polypeptide binding]; other site 418127005583 NAD binding pocket [chemical binding]; other site 418127005584 ATP binding pocket [chemical binding]; other site 418127005585 Mg binding site [ion binding]; other site 418127005586 active-site loop [active] 418127005587 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 418127005588 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: NAPRTase_A; cd01570 418127005589 active site 418127005590 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(...; Region: NOS_oxygenase_prok; cd00794 418127005591 active site 418127005592 dimer interface [polypeptide binding]; other site 418127005593 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 418127005594 Prephenate dehydratase; Region: PDT; pfam00800 418127005595 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 418127005596 putative L-Phe binding site [chemical binding]; other site 418127005597 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 418127005598 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 418127005599 transmembrane helices; other site 418127005600 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 418127005601 Isochorismatase family; Region: Isochorismatase; pfam00857 418127005602 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 418127005603 catalytic triad [active] 418127005604 conserved cis-peptide bond; other site 418127005605 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 418127005606 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl10010 418127005607 DHHA2 domain; Region: DHHA2; pfam02833 418127005608 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 418127005609 NAD(P) binding site [chemical binding]; other site 418127005610 catalytic residues [active] 418127005611 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 418127005612 YolD-like protein; Region: YolD; pfam08863 418127005613 Transposase domain (DUF772); Region: DUF772; cl12084 418127005614 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 418127005615 active site 418127005616 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 418127005617 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 418127005618 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 418127005619 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 418127005620 Walker A/P-loop; other site 418127005621 ATP binding site [chemical binding]; other site 418127005622 Q-loop/lid; other site 418127005623 ABC transporter signature motif; other site 418127005624 Walker B; other site 418127005625 D-loop; other site 418127005626 H-loop/switch region; other site 418127005627 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 418127005628 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 418127005629 Walker A/P-loop; other site 418127005630 ATP binding site [chemical binding]; other site 418127005631 Q-loop/lid; other site 418127005632 ABC transporter signature motif; other site 418127005633 Walker B; other site 418127005634 D-loop; other site 418127005635 H-loop/switch region; other site 418127005636 Predicted transcriptional regulators [Transcription]; Region: COG1725 418127005637 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 418127005638 DNA-binding site [nucleotide binding]; DNA binding site 418127005639 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 418127005640 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127005641 homodimer interface [polypeptide binding]; other site 418127005642 catalytic residue [active] 418127005643 MAP domain; Region: MAP; pfam03642 418127005644 MAP domain; Region: MAP; pfam03642 418127005645 MAP domain; Region: MAP; pfam03642 418127005646 MAP domain; Region: MAP; pfam03642 418127005647 MAP domain; Region: MAP; pfam03642 418127005648 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 418127005649 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 418127005650 Bacterial SH3 domain; Region: SH3_3; cl02551 418127005651 Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821 418127005652 NlpC/P60 family; Region: NLPC_P60; cl11438 418127005653 Bacteriophage holin; Region: Phage_holin_1; cl02344 418127005654 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 418127005655 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127005656 Ligand-gated ion channel; Region: Lig_chan; pfam00060 418127005657 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 418127005658 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 418127005659 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 418127005660 Phage tail protein; Region: Sipho_tail; cl11462 418127005661 Phage tail protein; Region: Sipho_tail; cl11462 418127005662 Phage-related minor tail protein [Function unknown]; Region: COG5280 418127005663 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 418127005664 Phage-related protein [Function unknown]; Region: COG5412 418127005665 Peptidase family M23; Region: Peptidase_M23; pfam01551 418127005666 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 418127005667 N-acetyl-D-glucosamine binding site [chemical binding]; other site 418127005668 catalytic residue [active] 418127005669 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 418127005670 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 418127005671 Phage capsid family; Region: Phage_capsid; pfam05065 418127005672 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 418127005673 oligomer interface [polypeptide binding]; other site 418127005674 active site residues [active] 418127005675 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 418127005676 Phage-related protein [Function unknown]; Region: COG4695; cl01923 418127005677 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 418127005678 Phage Terminase; Region: Terminase_1; pfam03354 418127005679 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 418127005680 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 418127005681 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 418127005682 Transcriptional activator RinB; Region: RinB; pfam06116 418127005683 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 418127005684 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 418127005685 trimer interface [polypeptide binding]; other site 418127005686 active site 418127005687 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 418127005688 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 418127005689 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 418127005690 Endodeoxyribonuclease RusA; Region: RusA; cl01885 418127005691 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 418127005692 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 418127005693 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 418127005694 dimer interface [polypeptide binding]; other site 418127005695 ssDNA binding site [nucleotide binding]; other site 418127005696 tetramer (dimer of dimers) interface [polypeptide binding]; other site 418127005697 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 418127005698 RecT family; Region: RecT; cl04285 418127005699 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 418127005700 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 418127005701 Hypothetical protein of unknown function (DUF2482); Region: DUF2482; pfam10655 418127005702 Protein of unknown function (DUF1270); Region: DUF1270; pfam06900 418127005703 Domain of unknown function (DUF771); Region: DUF771; cl09962 418127005704 AntA/AntB antirepressor; Region: AntA; cl01430 418127005705 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 418127005706 Protein of unknown function (DUF739); Region: DUF739; pfam05339 418127005707 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 418127005708 non-specific DNA binding site [nucleotide binding]; other site 418127005709 salt bridge; other site 418127005710 sequence-specific DNA binding site [nucleotide binding]; other site 418127005711 Predicted transcriptional regulator [Transcription]; Region: COG2932 418127005712 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 418127005713 Catalytic site [active] 418127005714 HIRAN domain; Region: HIRAN; pfam08797 418127005715 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 418127005716 Phage integrase family; Region: Phage_integrase; pfam00589 418127005717 Int/Topo IB signature motif; other site 418127005718 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 418127005719 putative catalytic site [active] 418127005720 phosphate binding site [ion binding]; other site 418127005721 metal binding site A [ion binding]; metal-binding site 418127005722 metal binding site C [ion binding]; metal-binding site 418127005723 metal binding site B [ion binding]; metal-binding site 418127005724 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 418127005725 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 418127005726 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 418127005727 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 418127005728 metal binding site [ion binding]; metal-binding site 418127005729 dimer interface [polypeptide binding]; other site 418127005730 Cation transport protein; Region: TrkH; cl10514 418127005731 Cation transport protein; Region: TrkH; cl10514 418127005732 Cation transport protein; Region: TrkH; cl10514 418127005733 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 418127005734 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127005735 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 418127005736 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127005737 superantigen-like protein; Reviewed; Region: PRK13350 418127005738 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 418127005739 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 418127005740 Terminase small subunit; Region: Terminase_2; cl01513 418127005741 Coat F domain; Region: Coat_F; cl02368 418127005742 hydrolase, hydrolyzing O-glycosyl compounds; Region: PLN02219; cl14104 418127005743 Domain of unknown function (DUF927); Region: DUF927; cl12098 418127005744 Predicted GTPase [General function prediction only]; Region: COG2403 418127005745 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 418127005746 Protein of unknown function (DUF1474); Region: DUF1474; pfam07342 418127005747 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 418127005748 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 418127005749 non-specific DNA binding site [nucleotide binding]; other site 418127005750 salt bridge; other site 418127005751 sequence-specific DNA binding site [nucleotide binding]; other site 418127005752 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 418127005753 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 418127005754 Phage integrase family; Region: Phage_integrase; pfam00589 418127005755 Int/Topo IB signature motif; other site 418127005756 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 418127005757 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 418127005758 ring oligomerisation interface [polypeptide binding]; other site 418127005759 ATP/Mg binding site [chemical binding]; other site 418127005760 stacking interactions; other site 418127005761 hinge regions; other site 418127005762 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 418127005763 oligomerisation interface [polypeptide binding]; other site 418127005764 mobile loop; other site 418127005765 roof hairpin; other site 418127005766 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 418127005767 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 418127005768 dimer interface [polypeptide binding]; other site 418127005769 FMN binding site [chemical binding]; other site 418127005770 Predicted amidohydrolase [General function prediction only]; Region: COG0388 418127005771 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 418127005772 putative active site [active] 418127005773 catalytic triad [active] 418127005774 putative dimer interface [polypeptide binding]; other site 418127005775 delta-hemolysin; Provisional; Region: PRK14752 418127005776 Accessory gene regulator B; Region: AgrB; cl01873 418127005777 Staphylococcal AgrD protein; Region: AgrD; cl05477 418127005778 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 418127005779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 418127005780 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 418127005781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 418127005782 active site 418127005783 phosphorylation site [posttranslational modification] 418127005784 intermolecular recognition site; other site 418127005785 dimerization interface [polypeptide binding]; other site 418127005786 LytTr DNA-binding domain; Region: LytTR; cl04498 418127005787 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 418127005788 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 418127005789 putative substrate binding site [chemical binding]; other site 418127005790 putative ATP binding site [chemical binding]; other site 418127005791 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 418127005792 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 418127005793 substrate binding [chemical binding]; other site 418127005794 active site 418127005795 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 418127005796 Transcriptional regulators [Transcription]; Region: PurR; COG1609 418127005797 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 418127005798 DNA binding site [nucleotide binding] 418127005799 domain linker motif; other site 418127005800 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 418127005801 dimerization interface [polypeptide binding]; other site 418127005802 ligand binding site [chemical binding]; other site 418127005803 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 418127005804 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-...; Region: SirA_YedF_YeeD; cd00291 418127005805 CPxP motif; other site 418127005806 YeeE/YedE family (DUF395); Region: DUF395; cl01018 418127005807 putative inner membrane protein; Provisional; Region: PRK11099 418127005808 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 418127005809 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 418127005810 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127005811 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 418127005812 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 418127005813 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 418127005814 ABC transporter; Region: ABC_tran_2; pfam12848 418127005815 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 418127005816 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 418127005817 MutS-like homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-...; Region: ABC_MutS-like; cd03283 418127005818 Walker A/P-loop; other site 418127005819 ATP binding site [chemical binding]; other site 418127005820 Q-loop/lid; other site 418127005821 ABC transporter signature motif; other site 418127005822 Walker B; other site 418127005823 D-loop; other site 418127005824 H-loop/switch region; other site 418127005825 UGMP family protein; Validated; Region: PRK09604 418127005826 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 418127005827 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 418127005828 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 418127005829 Coenzyme A binding pocket [chemical binding]; other site 418127005830 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 418127005831 Glycoprotease family; Region: Peptidase_M22; pfam00814 418127005832 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 418127005833 Dehydratase family; Region: ILVD_EDD; cl00340 418127005834 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 418127005835 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 418127005836 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 418127005837 PYR/PP interface [polypeptide binding]; other site 418127005838 dimer interface [polypeptide binding]; other site 418127005839 TPP binding site [chemical binding]; other site 418127005840 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 418127005841 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 418127005842 TPP-binding site [chemical binding]; other site 418127005843 dimer interface [polypeptide binding]; other site 418127005844 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 418127005845 ketol-acid reductoisomerase; Provisional; Region: PRK05479 418127005846 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127005847 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 418127005848 2-isopropylmalate synthase; Validated; Region: PRK00915 418127005849 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 418127005850 active site 418127005851 catalytic residues [active] 418127005852 metal binding site [ion binding]; metal-binding site 418127005853 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 418127005854 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 418127005855 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 418127005856 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 418127005857 substrate binding site [chemical binding]; other site 418127005858 ligand binding site [chemical binding]; other site 418127005859 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 418127005860 substrate binding site [chemical binding]; other site 418127005861 threonine dehydratase; Validated; Region: PRK08639 418127005862 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 418127005863 tetramer interface [polypeptide binding]; other site 418127005864 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127005865 catalytic residue [active] 418127005866 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 418127005867 putative Ile/Val binding site [chemical binding]; other site 418127005868 hypothetical protein; Provisional; Region: PRK04351 418127005869 SprT homologues; Region: SprT; cl01182 418127005870 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 418127005871 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 418127005872 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 418127005873 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin...; Region: S1_Tex; cd05685 418127005874 RNA binding site [nucleotide binding]; other site 418127005875 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 418127005876 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 418127005877 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 418127005878 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 418127005879 DNA binding residues [nucleotide binding] 418127005880 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 418127005881 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 418127005882 anti sigma factor interaction site; other site 418127005883 regulatory phosphorylation site [posttranslational modification]; other site 418127005884 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 418127005885 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 418127005886 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 418127005887 PemK-like protein; Region: PemK; cl00995 418127005888 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 418127005889 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 418127005890 active site 418127005891 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 418127005892 dimer interface [polypeptide binding]; other site 418127005893 substrate binding site [chemical binding]; other site 418127005894 catalytic residues [active] 418127005895 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 418127005896 Bacterial membrane flanked domain; Region: DUF304; cl01348 418127005897 Predicted membrane protein [Function unknown]; Region: COG3428 418127005898 Bacterial membrane flanked domain; Region: DUF304; cl01348 418127005899 Bacterial membrane flanked domain; Region: DUF304; cl01348 418127005900 Bacterial membrane flanked domain; Region: DUF304; cl01348 418127005901 K+-transporting ATPase, c chain; Region: KdpC; cl00944 418127005902 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 418127005903 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 418127005904 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 418127005905 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; cl00903 418127005906 Potassium-transporting ATPase A subunit; Region: KdpA; pfam03814 418127005907 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 418127005908 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 418127005909 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 418127005910 Ligand Binding Site [chemical binding]; other site 418127005911 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 418127005912 dimer interface [polypeptide binding]; other site 418127005913 phosphorylation site [posttranslational modification] 418127005914 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 418127005915 ATP binding site [chemical binding]; other site 418127005916 Mg2+ binding site [ion binding]; other site 418127005917 G-X-G motif; other site 418127005918 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 418127005919 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 418127005920 active site 418127005921 phosphorylation site [posttranslational modification] 418127005922 intermolecular recognition site; other site 418127005923 dimerization interface [polypeptide binding]; other site 418127005924 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 418127005925 DNA binding site [nucleotide binding] 418127005926 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 418127005927 Transposase; Region: DDE_Tnp_ISL3; pfam01610 418127005928 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 418127005929 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 418127005930 ATP binding site [chemical binding]; other site 418127005931 Mg++ binding site [ion binding]; other site 418127005932 motif III; other site 418127005933 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 418127005934 nucleotide binding region [chemical binding]; other site 418127005935 ATP-binding site [chemical binding]; other site 418127005936 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 418127005937 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 418127005938 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 418127005939 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 418127005940 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 418127005941 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 418127005942 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 418127005943 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 418127005944 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 418127005945 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 418127005946 putative homotetramer interface [polypeptide binding]; other site 418127005947 putative homodimer interface [polypeptide binding]; other site 418127005948 allosteric switch controlling residues; other site 418127005949 putative metal binding site [ion binding]; other site 418127005950 putative homodimer-homodimer interface [polypeptide binding]; other site 418127005951 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 418127005952 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 418127005953 putative active site [active] 418127005954 catalytic site [active] 418127005955 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 418127005956 putative active site [active] 418127005957 catalytic site [active] 418127005958 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 418127005959 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 418127005960 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 418127005961 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 418127005962 thiamine phosphate binding site [chemical binding]; other site 418127005963 active site 418127005964 pyrophosphate binding site [ion binding]; other site 418127005965 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 418127005966 substrate binding site [chemical binding]; other site 418127005967 multimerization interface [polypeptide binding]; other site 418127005968 ATP binding site [chemical binding]; other site 418127005969 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427 418127005970 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 418127005971 dimer interface [polypeptide binding]; other site 418127005972 substrate binding site [chemical binding]; other site 418127005973 ATP binding site [chemical binding]; other site 418127005974 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 418127005975 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 418127005976 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 418127005977 dimer interface [polypeptide binding]; other site 418127005978 ssDNA binding site [nucleotide binding]; other site 418127005979 tetramer (dimer of dimers) interface [polypeptide binding]; other site 418127005980 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 418127005981 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 418127005982 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 418127005983 hinge; other site 418127005984 active site 418127005985 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 418127005986 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735 418127005987 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 418127005988 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 418127005989 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 418127005990 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 418127005991 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 418127005992 alpha subunit interaction interface [polypeptide binding]; other site 418127005993 Walker A motif; other site 418127005994 ATP binding site [chemical binding]; other site 418127005995 Walker B motif; other site 418127005996 inhibitor binding site; inhibition site 418127005997 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 418127005998 ATP synthase; Region: ATP-synt; cl00365 418127005999 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 418127006000 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 418127006001 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 418127006002 beta subunit interaction interface [polypeptide binding]; other site 418127006003 Walker A motif; other site 418127006004 ATP binding site [chemical binding]; other site 418127006005 Walker B motif; other site 418127006006 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 418127006007 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 418127006008 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 418127006009 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 418127006010 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 418127006011 ATP synthase subunit C; Region: ATP-synt_C; cl00466 418127006012 ATP synthase A chain; Region: ATP-synt_A; cl00413 418127006013 Bacterial ATP synthase I; Region: Bac_ATP_syn_I; pfam05468 418127006014 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 418127006015 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues...; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 418127006016 active site 418127006017 homodimer interface [polypeptide binding]; other site 418127006018 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 418127006019 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 418127006020 dimer interface [polypeptide binding]; other site 418127006021 glycine-pyridoxal phosphate binding site [chemical binding]; other site 418127006022 active site 418127006023 folate binding site [chemical binding]; other site 418127006024 Protein of unknown function (DUF436); Region: DUF436; cl01860 418127006025 Low molecular weight phosphatase family; Region: LMWPc; cd00115 418127006026 Active site [active] 418127006027 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 418127006028 SUA5 domain; Region: SUA5; pfam03481 418127006029 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 418127006030 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 418127006031 S-adenosylmethionine binding site [chemical binding]; other site 418127006032 peptide chain release factor 1; Validated; Region: prfA; PRK00591 418127006033 RF-1 domain; Region: RF-1; cl02875 418127006034 RF-1 domain; Region: RF-1; cl02875 418127006035 Thymidine kinase; Region: TK; cl00631 418127006036 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 418127006037 transcription termination factor Rho; Provisional; Region: rho; PRK09376 418127006038 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 418127006039 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent...; Region: Rho_CSD; cd04459 418127006040 RNA binding site [nucleotide binding]; other site 418127006041 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128 418127006042 multimer interface [polypeptide binding]; other site 418127006043 Walker A motif; other site 418127006044 ATP binding site [chemical binding]; other site 418127006045 Walker B motif; other site 418127006046 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 418127006047 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 418127006048 NAD binding site [chemical binding]; other site 418127006049 catalytic residues [active] 418127006050 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127006051 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 418127006052 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 418127006053 hinge; other site 418127006054 active site 418127006055 hypothetical protein; Provisional; Region: PRK08185 418127006056 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 418127006057 intersubunit interface [polypeptide binding]; other site 418127006058 active site 418127006059 zinc binding site [ion binding]; other site 418127006060 Na+ binding site [ion binding]; other site 418127006061 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 418127006062 CTP synthetase; Validated; Region: pyrG; PRK05380 418127006063 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 418127006064 Catalytic site [active] 418127006065 Active site [active] 418127006066 UTP binding site [chemical binding]; other site 418127006067 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 418127006068 active site 418127006069 putative oxyanion hole; other site 418127006070 catalytic triad [active] 418127006071 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 418127006072 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 418127006073 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 418127006074 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 418127006075 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 418127006076 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 418127006077 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 418127006078 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 418127006079 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 418127006080 metal binding site [ion binding]; metal-binding site 418127006081 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 418127006082 Predicted membrane protein [Function unknown]; Region: COG4270 418127006083 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 418127006084 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 418127006085 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 418127006086 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 418127006087 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 418127006088 intersubunit interface [polypeptide binding]; other site 418127006089 active site 418127006090 catalytic residue [active] 418127006091 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 418127006092 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 418127006093 Ferritin-like domain; Region: Ferritin; pfam00210 418127006094 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 418127006095 dimerization interface [polypeptide binding]; other site 418127006096 DPS ferroxidase diiron center [ion binding]; other site 418127006097 ion pore; other site 418127006098 Protein of unknown function, DUF393; Region: DUF393; cl01136 418127006099 EVE domain; Region: EVE; cl00728 418127006100 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 418127006101 mannose-6-phosphate isomerase; Provisional; Region: PRK15131; cl14659 418127006102 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 418127006103 NAD(P) binding site [chemical binding]; other site 418127006104 putative active site [active] 418127006105 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 418127006106 dimerization interface [polypeptide binding]; other site 418127006107 putative DNA binding site [nucleotide binding]; other site 418127006108 putative Zn2+ binding site [ion binding]; other site 418127006109 Cation efflux family; Region: Cation_efflux; cl00316 418127006110 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 418127006111 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 418127006112 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 418127006113 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 418127006114 active site 418127006115 motif I; other site 418127006116 motif II; other site 418127006117 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 418127006118 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 418127006119 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 418127006120 Walker A/P-loop; other site 418127006121 ATP binding site [chemical binding]; other site 418127006122 Q-loop/lid; other site 418127006123 ABC transporter signature motif; other site 418127006124 Walker B; other site 418127006125 D-loop; other site 418127006126 H-loop/switch region; other site 418127006127 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 418127006128 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714 418127006129 glutaminase active site [active] 418127006130 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 418127006131 dimer interface [polypeptide binding]; other site 418127006132 active site 418127006133 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 418127006134 dimer interface [polypeptide binding]; other site 418127006135 active site 418127006136 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 418127006137 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 418127006138 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_mannitol; cd05567 418127006139 active site 418127006140 P-loop; other site 418127006141 phosphorylation site [posttranslational modification] 418127006142 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 418127006143 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127006144 PRD domain; Region: PRD; pfam00874 418127006145 PRD domain; Region: PRD; pfam00874 418127006146 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 418127006147 P-loop; other site 418127006148 active site 418127006149 phosphorylation site [posttranslational modification] 418127006150 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 418127006151 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 418127006152 active site 418127006153 phosphorylation site [posttranslational modification] 418127006154 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 418127006155 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 418127006156 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 418127006157 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 418127006158 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127006159 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127006160 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127006161 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127006162 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 418127006163 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 418127006164 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802 418127006165 active site 418127006166 substrate binding site [chemical binding]; other site 418127006167 metal binding site [ion binding]; metal-binding site 418127006168 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 418127006169 YbbR-like protein; Region: YbbR; pfam07949 418127006170 TIGR00159 family protein; Region: TIGR00159 418127006171 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 418127006172 Arginase family; Region: Arginase; cl00306 418127006173 RecA-family ATPase [DNA replication, recombination, and repair]; Region: RepA; COG3598 418127006174 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 418127006175 Walker A motif; other site 418127006176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127006177 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 418127006178 putative substrate translocation pore; other site 418127006179 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 418127006180 Haemolysin-III related; Region: HlyIII; cl03831 418127006181 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 418127006182 substrate binding site [chemical binding]; other site 418127006183 dimerization interface [polypeptide binding]; other site 418127006184 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 418127006185 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 418127006186 Nucleoside recognition; Region: Gate; cl00486 418127006187 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 418127006188 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 418127006189 ABC-ATPase subunit interface; other site 418127006190 dimer interface [polypeptide binding]; other site 418127006191 putative PBP binding regions; other site 418127006192 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 418127006193 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 418127006194 ABC-ATPase subunit interface; other site 418127006195 dimer interface [polypeptide binding]; other site 418127006196 putative PBP binding regions; other site 418127006197 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 418127006198 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor...; Region: FhuD; cd01146 418127006199 siderophore binding site; other site 418127006200 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 418127006201 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 418127006202 dimer interface [polypeptide binding]; other site 418127006203 active site 418127006204 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 418127006205 substrate binding site [chemical binding]; other site 418127006206 catalytic residue [active] 418127006207 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 418127006208 IucA / IucC family; Region: IucA_IucC; pfam04183 418127006209 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 418127006210 H+ Antiporter protein; Region: 2A0121; TIGR00900 418127006211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127006212 putative substrate translocation pore; other site 418127006213 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 418127006214 IucA / IucC family; Region: IucA_IucC; pfam04183 418127006215 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 418127006216 Protein of unknown function (DUF322); Region: DUF322; cl00574 418127006217 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 418127006218 BCCT family transporter; Region: BCCT; cl00569 418127006219 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 418127006220 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 418127006221 putative NAD(P) binding site [chemical binding]; other site 418127006222 dimer interface [polypeptide binding]; other site 418127006223 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 418127006224 Prostaglandin dehydrogenases; Region: PGDH; cd05288 418127006225 NAD(P) binding site [chemical binding]; other site 418127006226 substrate binding site [chemical binding]; other site 418127006227 dimer interface [polypeptide binding]; other site 418127006228 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; cl14892 418127006229 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 418127006230 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 418127006231 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 418127006232 P-loop; other site 418127006233 active site 418127006234 phosphorylation site [posttranslational modification] 418127006235 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 418127006236 methionine cluster; other site 418127006237 active site 418127006238 phosphorylation site [posttranslational modification] 418127006239 metal binding site [ion binding]; metal-binding site 418127006240 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 418127006241 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 418127006242 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 418127006243 putative substrate binding site [chemical binding]; other site 418127006244 putative ATP binding site [chemical binding]; other site 418127006245 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 418127006246 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 418127006247 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 418127006248 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127006249 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 418127006250 NAD-dependent deacetylase; Provisional; Region: PRK14138 418127006251 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 418127006252 NAD+ binding site [chemical binding]; other site 418127006253 substrate binding site [chemical binding]; other site 418127006254 putative Zn binding site [ion binding]; other site 418127006255 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 418127006256 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 418127006257 active site 418127006258 catalytic tetrad [active] 418127006259 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 418127006260 DNA binding residues [nucleotide binding] 418127006261 putative dimer interface [polypeptide binding]; other site 418127006262 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues...; Region: GAG_Lyase; cd01083 418127006263 substrate binding site [chemical binding]; other site 418127006264 catalytic residues [active] 418127006265 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 418127006266 Peptidase family M23; Region: Peptidase_M23; pfam01551 418127006267 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 418127006268 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 418127006269 active site 418127006270 motif I; other site 418127006271 motif II; other site 418127006272 MAP domain; Region: MAP; pfam03642 418127006273 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 418127006274 acetolactate synthase; Reviewed; Region: PRK08617 418127006275 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 418127006276 PYR/PP interface [polypeptide binding]; other site 418127006277 dimer interface [polypeptide binding]; other site 418127006278 TPP binding site [chemical binding]; other site 418127006279 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 418127006280 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 418127006281 TPP-binding site [chemical binding]; other site 418127006282 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 418127006283 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 418127006284 putative active site [active] 418127006285 putative NTP binding site [chemical binding]; other site 418127006286 putative nucleic acid binding site [nucleotide binding]; other site 418127006287 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 418127006288 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 418127006289 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 418127006290 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 418127006291 23S rRNA interface [nucleotide binding]; other site 418127006292 L3 interface [polypeptide binding]; other site 418127006293 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 418127006294 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 418127006295 dimerization interface 3.5A [polypeptide binding]; other site 418127006296 active site 418127006297 Cobalt transport protein; Region: CbiQ; cl00463 418127006298 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646 418127006299 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 418127006300 Walker A/P-loop; other site 418127006301 ATP binding site [chemical binding]; other site 418127006302 Q-loop/lid; other site 418127006303 ABC transporter signature motif; other site 418127006304 Walker B; other site 418127006305 D-loop; other site 418127006306 H-loop/switch region; other site 418127006307 Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370 418127006308 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648 418127006309 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 418127006310 Walker A/P-loop; other site 418127006311 ATP binding site [chemical binding]; other site 418127006312 Q-loop/lid; other site 418127006313 ABC transporter signature motif; other site 418127006314 Walker B; other site 418127006315 D-loop; other site 418127006316 H-loop/switch region; other site 418127006317 Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370 418127006318 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 418127006319 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 418127006320 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 418127006321 alphaNTD homodimer interface [polypeptide binding]; other site 418127006322 alphaNTD - beta interaction site [polypeptide binding]; other site 418127006323 alphaNTD - beta' interaction site [polypeptide binding]; other site 418127006324 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 418127006325 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 418127006326 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 418127006327 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 418127006328 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 418127006329 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 418127006330 rRNA binding site [nucleotide binding]; other site 418127006331 predicted 30S ribosome binding site; other site 418127006332 adenylate kinase; Reviewed; Region: adk; PRK00279 418127006333 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 418127006334 AMP-binding site [chemical binding]; other site 418127006335 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 418127006336 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 418127006337 SecY translocase; Region: SecY; pfam00344 418127006338 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 418127006339 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658 418127006340 23S rRNA binding site [nucleotide binding]; other site 418127006341 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 418127006342 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 418127006343 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 418127006344 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 418127006345 5S rRNA interface [nucleotide binding]; other site 418127006346 L27 interface [polypeptide binding]; other site 418127006347 23S rRNA interface [nucleotide binding]; other site 418127006348 L5 interface [polypeptide binding]; other site 418127006349 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 418127006350 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 418127006351 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 418127006352 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 418127006353 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 418127006354 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 418127006355 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 418127006356 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 418127006357 KOW motif; Region: KOW; cl00354 418127006358 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 418127006359 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 418127006360 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cl09943 418127006361 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 418127006362 23S rRNA interface [nucleotide binding]; other site 418127006363 5S rRNA interface [nucleotide binding]; other site 418127006364 putative antibiotic binding site [chemical binding]; other site 418127006365 L25 interface [polypeptide binding]; other site 418127006366 L27 interface [polypeptide binding]; other site 418127006367 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 418127006368 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 418127006369 G-X-X-G motif; other site 418127006370 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 418127006371 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 418127006372 putative translocon binding site; other site 418127006373 protein-rRNA interface [nucleotide binding]; other site 418127006374 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 418127006375 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 418127006376 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 418127006377 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 418127006378 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 418127006379 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 418127006380 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 418127006381 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 418127006382 Sulfate transporter family; Region: Sulfate_transp; cl00967 418127006383 Permease family; Region: Xan_ur_permease; pfam00860 418127006384 DNA topoisomerase III; Provisional; Region: PRK07726 418127006385 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by:...; Region: TOPRIM_TopoIA_TopoIII; cd03362 418127006386 active site 418127006387 putative interdomain interaction site [polypeptide binding]; other site 418127006388 putative metal-binding site [ion binding]; other site 418127006389 putative nucleotide binding site [chemical binding]; other site 418127006390 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 418127006391 domain I; other site 418127006392 DNA binding groove [nucleotide binding] 418127006393 phosphate binding site [ion binding]; other site 418127006394 domain II; other site 418127006395 domain III; other site 418127006396 nucleotide binding site [chemical binding]; other site 418127006397 catalytic site [active] 418127006398 domain IV; other site 418127006399 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 418127006400 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 418127006401 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 418127006402 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 418127006403 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 418127006404 Membrane transport protein; Region: Mem_trans; cl09117 418127006405 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 418127006406 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 418127006407 FemAB family; Region: FemAB; cl11444 418127006408 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127006409 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127006410 Major Facilitator Superfamily; Region: MFS_1; pfam07690 418127006411 putative substrate translocation pore; other site 418127006412 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127006413 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 418127006414 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 418127006415 FeS/SAM binding site; other site 418127006416 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 418127006417 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 418127006418 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 418127006419 GTP binding site [chemical binding]; other site 418127006420 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 418127006421 MoaE interaction surface [polypeptide binding]; other site 418127006422 MoeB interaction surface [polypeptide binding]; other site 418127006423 thiocarboxylated glycine; other site 418127006424 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 418127006425 MoaE homodimer interface [polypeptide binding]; other site 418127006426 MoaD interaction [polypeptide binding]; other site 418127006427 active site residues [active] 418127006428 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 418127006429 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 418127006430 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 418127006431 dimer interface [polypeptide binding]; other site 418127006432 putative functional site; other site 418127006433 putative MPT binding site; other site 418127006434 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a...; Region: MoaC_PE; cd01420 418127006435 trimer interface [polypeptide binding]; other site 418127006436 dimer interface [polypeptide binding]; other site 418127006437 putative active site [active] 418127006438 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886 418127006439 MPT binding site; other site 418127006440 trimer interface [polypeptide binding]; other site 418127006441 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 418127006442 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 418127006443 ATP binding site [chemical binding]; other site 418127006444 substrate interface [chemical binding]; other site 418127006445 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 418127006446 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 418127006447 Walker A/P-loop; other site 418127006448 ATP binding site [chemical binding]; other site 418127006449 Q-loop/lid; other site 418127006450 ABC transporter signature motif; other site 418127006451 Walker B; other site 418127006452 D-loop; other site 418127006453 H-loop/switch region; other site 418127006454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 418127006455 dimer interface [polypeptide binding]; other site 418127006456 conserved gate region; other site 418127006457 putative PBP binding loops; other site 418127006458 ABC-ATPase subunit interface; other site 418127006459 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 418127006460 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 418127006461 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 418127006462 BioY family; Region: BioY; cl00560 418127006463 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base...; Region: nuc_hydro_TvIAG; cd02647 418127006464 active site 418127006465 dimerization interface [polypeptide binding]; other site 418127006466 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 418127006467 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 418127006468 intersubunit interface [polypeptide binding]; other site 418127006469 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 418127006470 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 418127006471 Urea transporter; Region: UT; cl01829 418127006472 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 418127006473 alpha-gamma subunit interface [polypeptide binding]; other site 418127006474 beta-gamma subunit interface [polypeptide binding]; other site 418127006475 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_beta; cd00407 418127006476 gamma-beta subunit interface [polypeptide binding]; other site 418127006477 alpha-beta subunit interface [polypeptide binding]; other site 418127006478 urease subunit alpha; Reviewed; Region: ureC; PRK13207 418127006479 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 418127006480 subunit interactions [polypeptide binding]; other site 418127006481 active site 418127006482 flap region; other site 418127006483 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 418127006484 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The C-...; Region: UreE; cd00571 418127006485 dimer interface [polypeptide binding]; other site 418127006486 catalytic residues [active] 418127006487 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 418127006488 UreF; Region: UreF; pfam01730 418127006489 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 418127006490 UreD urease accessory protein; Region: UreD; cl00530 418127006491 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127006492 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127006493 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127006494 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 418127006495 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 418127006496 NlpC/P60 family; Region: NLPC_P60; cl11438 418127006497 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 418127006498 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 418127006499 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127006500 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 418127006501 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 418127006502 NlpC/P60 family; Region: NLPC_P60; cl11438 418127006503 glyoxylate reductase; Reviewed; Region: PRK13243 418127006504 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127006505 hypothetical protein; Provisional; Region: PRK06753 418127006506 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 418127006507 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 418127006508 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 418127006509 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 418127006510 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 418127006511 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 418127006512 4Fe-4S binding domain; Region: Fer4; cl02805 418127006513 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H)...; Region: MopB_Formate-Dh-H; cd02753 418127006514 [4Fe-4S] binding site [ion binding]; other site 418127006515 molybdopterin cofactor binding site; other site 418127006516 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 418127006517 molybdopterin cofactor binding site; other site 418127006518 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 418127006519 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1,6-; Region: IMPase_like; cd01637 418127006520 active site 418127006521 Predicted transcriptional regulator [Transcription]; Region: COG2378 418127006522 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127006523 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 418127006524 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 418127006525 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 418127006526 putative active site [active] 418127006527 ethanolamine permease; Region: 2A0305; TIGR00908 418127006528 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 418127006529 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 418127006530 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 418127006531 active site 418127006532 motif I; other site 418127006533 motif II; other site 418127006534 Membrane transport protein; Region: Mem_trans; cl09117 418127006535 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 418127006536 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 418127006537 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 418127006538 active site turn [active] 418127006539 phosphorylation site [posttranslational modification] 418127006540 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 418127006541 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 418127006542 putative active site [active] 418127006543 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 418127006544 putative hydrophobic ligand binding site [chemical binding]; other site 418127006545 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 418127006546 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 418127006547 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 418127006548 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 418127006549 oxidoreductase; Provisional; Region: PRK07985 418127006550 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127006551 NAD(P) binding site [chemical binding]; other site 418127006552 active site 418127006553 YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 418127006554 amidohydrolase; Region: amidohydrolases; TIGR01891 418127006555 metal binding site [ion binding]; metal-binding site 418127006556 dimer interface [polypeptide binding]; other site 418127006557 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 418127006558 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria...; Region: Imidazolone-5PH; cd01296 418127006559 active site 418127006560 urocanate hydratase; Provisional; Region: PRK05414 418127006561 urocanate hydratase; Region: hutU; TIGR01228 418127006562 Transcriptional regulator [Transcription]; Region: LysR; COG0583 418127006563 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127006564 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 418127006565 dimerization interface [polypeptide binding]; other site 418127006566 FosB, a fosfomycin resistance protein, catalyzes the Mg(II) dependent addition of L-cysteine to the epoxide ring of fosfomycin; Region: FosB; cd08363 418127006567 putative active site [active] 418127006568 putative Mg binding site [ion binding]; other site 418127006569 Arginase family; Region: Arginase; cl00306 418127006570 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 418127006571 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 418127006572 tetramer (dimer of dimers) interface [polypeptide binding]; other site 418127006573 active site 418127006574 dimer interface [polypeptide binding]; other site 418127006575 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 418127006576 MOSC domain; Region: MOSC; pfam03473 418127006577 3-alpha domain; Region: 3-alpha; pfam03475 418127006578 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 418127006579 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 418127006580 active site 418127006581 catalytic residues [active] 418127006582 Uncharacterised BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 418127006583 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 418127006584 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 418127006585 This subfamily is involved in drug resistance, nodulation, lipid transport, and bacteriocin and lantibiotic immunity. In eubacteria and archaea, the typical organization consists of one ABC and one or two IMs. Eukaryote systems of the ABCA subfamily...; Region: ABC_putative_ATPase; cd03269 418127006586 Walker A/P-loop; other site 418127006587 ATP binding site [chemical binding]; other site 418127006588 Q-loop/lid; other site 418127006589 ABC transporter signature motif; other site 418127006590 Walker B; other site 418127006591 D-loop; other site 418127006592 H-loop/switch region; other site 418127006593 Protein of unknown function (DUF805); Region: DUF805; cl01224 418127006594 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 418127006595 active site 418127006596 DNA binding site [nucleotide binding] 418127006597 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 418127006598 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 418127006599 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal...; Region: IDI-2_FMN; cd02811 418127006600 homotetramer interface [polypeptide binding]; other site 418127006601 FMN binding site [chemical binding]; other site 418127006602 homodimer contacts [polypeptide binding]; other site 418127006603 putative active site [active] 418127006604 putative substrate binding site [chemical binding]; other site 418127006605 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 418127006606 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 418127006607 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 418127006608 active site 418127006609 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 418127006610 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 418127006611 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127006612 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 418127006613 putative substrate translocation pore; other site 418127006614 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 418127006615 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 418127006616 lipoyl-biotinyl attachment site [posttranslational modification]; other site 418127006617 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 418127006618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127006619 putative substrate translocation pore; other site 418127006620 Predicted membrane protein [Function unknown]; Region: COG4640 418127006621 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127006622 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 418127006623 putative active site [active] 418127006624 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 418127006625 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 418127006626 Walker A/P-loop; other site 418127006627 ATP binding site [chemical binding]; other site 418127006628 Q-loop/lid; other site 418127006629 ABC transporter signature motif; other site 418127006630 Walker B; other site 418127006631 D-loop; other site 418127006632 H-loop/switch region; other site 418127006633 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 418127006634 FtsX-like permease family; Region: FtsX; pfam02687 418127006635 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 418127006636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 418127006637 active site 418127006638 phosphorylation site [posttranslational modification] 418127006639 intermolecular recognition site; other site 418127006640 dimerization interface [polypeptide binding]; other site 418127006641 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 418127006642 DNA binding site [nucleotide binding] 418127006643 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 418127006644 dimerization interface [polypeptide binding]; other site 418127006645 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 418127006646 dimer interface [polypeptide binding]; other site 418127006647 phosphorylation site [posttranslational modification] 418127006648 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 418127006649 ATP binding site [chemical binding]; other site 418127006650 Mg2+ binding site [ion binding]; other site 418127006651 G-X-G motif; other site 418127006652 LytTr DNA-binding domain; Region: LytTR; cl04498 418127006653 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 418127006654 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 418127006655 Predicted dehydrogenase [General function prediction only]; Region: COG0579 418127006656 L-lactate permease; Region: Lactate_perm; cl00701 418127006657 glycolate transporter; Provisional; Region: PRK09695 418127006658 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 418127006659 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 418127006660 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 418127006661 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 418127006662 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 418127006663 NAD(P) binding site [chemical binding]; other site 418127006664 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 418127006665 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 418127006666 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 418127006667 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 418127006668 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 418127006669 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 418127006670 ABC-2 type transporter; Region: ABC2_membrane; cl11417 418127006671 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 418127006672 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 418127006673 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 418127006674 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 418127006675 active site turn [active] 418127006676 phosphorylation site [posttranslational modification] 418127006677 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 418127006678 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 418127006679 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 418127006680 Transposase; Region: DDE_Tnp_ISL3; pfam01610 418127006681 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 418127006682 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 418127006683 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 418127006684 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 418127006685 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 418127006686 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127006687 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 418127006688 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 418127006689 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127006690 putative substrate translocation pore; other site 418127006691 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 418127006692 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 418127006693 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 418127006694 DNA binding residues [nucleotide binding] 418127006695 dimer interface [polypeptide binding]; other site 418127006696 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 418127006697 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 418127006698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 418127006699 active site 418127006700 phosphorylation site [posttranslational modification] 418127006701 intermolecular recognition site; other site 418127006702 dimerization interface [polypeptide binding]; other site 418127006703 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 418127006704 DNA binding residues [nucleotide binding] 418127006705 dimerization interface [polypeptide binding]; other site 418127006706 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 418127006707 Histidine kinase; Region: HisKA_3; pfam07730 418127006708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 418127006709 ATP binding site [chemical binding]; other site 418127006710 Mg2+ binding site [ion binding]; other site 418127006711 G-X-G motif; other site 418127006712 GAF domain; Region: GAF; cl00853 418127006713 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 418127006714 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 418127006715 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 418127006716 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 418127006717 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate...; Region: MopB_Nitrate-R-NarG-like; cd02750 418127006718 [4Fe-4S] binding site [ion binding]; other site 418127006719 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 418127006720 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 418127006721 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 418127006722 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 418127006723 molybdopterin cofactor binding site; other site 418127006724 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 418127006725 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 418127006726 [2Fe-2S] cluster binding site [ion binding]; other site 418127006727 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 418127006728 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 418127006729 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 418127006730 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 418127006731 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 418127006732 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 418127006733 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a...; Region: CbiX_SirB_N; cd03416 418127006734 putative active site [active] 418127006735 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and...; Region: Chelatase_Class_II; cl02784 418127006736 active site 418127006737 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 418127006738 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 418127006739 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 418127006740 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 418127006741 putative hydrophobic ligand binding site [chemical binding]; other site 418127006742 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 418127006743 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 418127006744 intersubunit interface [polypeptide binding]; other site 418127006745 YodA lipocalin-like domain; Region: YodA; cl01365 418127006746 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 418127006747 Phd_YefM; Region: PhdYeFM; cl09153 418127006748 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 418127006749 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 418127006750 FemAB family; Region: FemAB; cl11444 418127006751 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 418127006752 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 418127006753 Walker A/P-loop; other site 418127006754 ATP binding site [chemical binding]; other site 418127006755 Q-loop/lid; other site 418127006756 ABC transporter signature motif; other site 418127006757 Walker B; other site 418127006758 D-loop; other site 418127006759 H-loop/switch region; other site 418127006760 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 418127006761 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 418127006762 putative PBP binding loops; other site 418127006763 dimer interface [polypeptide binding]; other site 418127006764 ABC-ATPase subunit interface; other site 418127006765 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 418127006766 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 418127006767 substrate binding pocket [chemical binding]; other site 418127006768 membrane-bound complex binding site; other site 418127006769 hinge residues; other site 418127006770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127006771 Major Facilitator Superfamily; Region: MFS_1; pfam07690 418127006772 putative substrate translocation pore; other site 418127006773 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127006774 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 418127006775 catalytic core [active] 418127006776 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 418127006777 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 418127006778 Cation efflux family; Region: Cation_efflux; cl00316 418127006779 B domain; Region: B; pfam02216 418127006780 B domain; Region: B; pfam02216 418127006781 C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621 418127006782 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 418127006783 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 418127006784 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 418127006785 6-carboxyhexanoate--CoA ligase; Region: BioW; cl00625 418127006786 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 418127006787 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 418127006788 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 418127006789 catalytic residue [active] 418127006790 biotin synthase; Validated; Region: PRK06256 418127006791 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 418127006792 FeS/SAM binding site; other site 418127006793 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 418127006794 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 418127006795 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 418127006796 inhibitor-cofactor binding pocket; inhibition site 418127006797 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127006798 catalytic residue [active] 418127006799 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 418127006800 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 418127006801 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 418127006802 Walker A/P-loop; other site 418127006803 ATP binding site [chemical binding]; other site 418127006804 Q-loop/lid; other site 418127006805 ABC transporter signature motif; other site 418127006806 Walker B; other site 418127006807 D-loop; other site 418127006808 H-loop/switch region; other site 418127006809 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 418127006810 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 418127006811 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 418127006812 Walker A/P-loop; other site 418127006813 ATP binding site [chemical binding]; other site 418127006814 Q-loop/lid; other site 418127006815 ABC transporter signature motif; other site 418127006816 Walker B; other site 418127006817 D-loop; other site 418127006818 H-loop/switch region; other site 418127006819 GtrA-like protein; Region: GtrA; cl00971 418127006820 Glycerate kinase family; Region: Gly_kinase; cl00841 418127006821 hypothetical protein; Provisional; Region: PRK11281 418127006822 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 418127006823 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127006824 putative substrate translocation pore; other site 418127006825 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 418127006826 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The...; Region: Peptidase_C39_like; cl00296 418127006827 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 418127006828 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 418127006829 active site 418127006830 metal binding site [ion binding]; metal-binding site 418127006831 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 418127006832 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 418127006833 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 418127006834 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 418127006835 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 418127006836 Beta-lactamase; Region: Beta-lactamase; cl01009 418127006837 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 418127006838 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127006839 NAD(P) binding site [chemical binding]; other site 418127006840 active site 418127006841 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 418127006842 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127006843 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 418127006844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127006845 putative substrate translocation pore; other site 418127006846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127006847 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 418127006848 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 418127006849 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 418127006850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 418127006851 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family...; Region: ABC_OpuCA_Osmoprotection; cd03295 418127006852 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 418127006853 Walker A/P-loop; other site 418127006854 ATP binding site [chemical binding]; other site 418127006855 Q-loop/lid; other site 418127006856 ABC transporter signature motif; other site 418127006857 Walker B; other site 418127006858 D-loop; other site 418127006859 H-loop/switch region; other site 418127006860 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 418127006861 Domain of unknown function (DU1801); Region: DUF1801; cl01838 418127006862 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 418127006863 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 418127006864 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 418127006865 substrate binding pocket [chemical binding]; other site 418127006866 catalytic triad [active] 418127006867 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 418127006868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127006869 putative substrate translocation pore; other site 418127006870 Uncharacterised protein family (UPF0014); Region: UPF0014; cl00424 418127006871 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 418127006872 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 418127006873 Walker A/P-loop; other site 418127006874 ATP binding site [chemical binding]; other site 418127006875 Q-loop/lid; other site 418127006876 ABC transporter signature motif; other site 418127006877 Walker B; other site 418127006878 D-loop; other site 418127006879 H-loop/switch region; other site 418127006880 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 418127006881 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 418127006882 oligomer interface [polypeptide binding]; other site 418127006883 active site 418127006884 metal binding site [ion binding]; metal-binding site 418127006885 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 418127006886 Phd_YefM; Region: PhdYeFM; cl09153 418127006887 Protein of unknown function (DUF1307); Region: DUF1307; cl01981 418127006888 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 418127006889 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 418127006890 active site 418127006891 FMN binding site [chemical binding]; other site 418127006892 substrate binding site [chemical binding]; other site 418127006893 3Fe-4S cluster binding site [ion binding]; other site 418127006894 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 418127006895 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127006896 Major Facilitator Superfamily; Region: MFS_1; pfam07690 418127006897 putative substrate translocation pore; other site 418127006898 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 418127006899 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 418127006900 Walker A/P-loop; other site 418127006901 ATP binding site [chemical binding]; other site 418127006902 Q-loop/lid; other site 418127006903 ABC transporter signature motif; other site 418127006904 Walker B; other site 418127006905 D-loop; other site 418127006906 H-loop/switch region; other site 418127006907 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 418127006908 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 418127006909 Walker A/P-loop; other site 418127006910 ATP binding site [chemical binding]; other site 418127006911 Q-loop/lid; other site 418127006912 ABC transporter signature motif; other site 418127006913 Walker B; other site 418127006914 D-loop; other site 418127006915 H-loop/switch region; other site 418127006916 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 418127006917 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 418127006918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 418127006919 dimer interface [polypeptide binding]; other site 418127006920 conserved gate region; other site 418127006921 ABC-ATPase subunit interface; other site 418127006922 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 418127006923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 418127006924 dimer interface [polypeptide binding]; other site 418127006925 conserved gate region; other site 418127006926 putative PBP binding loops; other site 418127006927 ABC-ATPase subunit interface; other site 418127006928 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 418127006929 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 418127006930 substrate binding site [chemical binding]; other site 418127006931 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 418127006932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 418127006933 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 418127006934 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 418127006935 short chain dehydrogenase; Validated; Region: PRK08589 418127006936 classical (c) SDRs; Region: SDR_c; cd05233 418127006937 NAD(P) binding site [chemical binding]; other site 418127006938 active site 418127006939 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 418127006940 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 418127006941 Uncharacterized conserved protein [Function unknown]; Region: COG2128 418127006942 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 418127006943 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 418127006944 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 418127006945 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 418127006946 classical (c) SDRs; Region: SDR_c; cd05233 418127006947 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 418127006948 NAD(P) binding site [chemical binding]; other site 418127006949 active site 418127006950 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 418127006951 Protein of unknown function, DUF576; Region: DUF576; cl04553 418127006952 Protein of unknown function, DUF576; Region: DUF576; cl04553 418127006953 Protein of unknown function, DUF576; Region: DUF576; cl04553 418127006954 Protein of unknown function, DUF576; Region: DUF576; cl04553 418127006955 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 418127006956 nucleotide binding region [chemical binding]; other site 418127006957 Restriction endonuclease [Defense mechanisms]; Region: COG3587 418127006958 ATP-binding site [chemical binding]; other site 418127006959 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 418127006960 Predicted HKD family nuclease [DNA replication, recombination, and repair]; Region: COG3886 418127006961 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 418127006962 putative homodimer interface [polypeptide binding]; other site 418127006963 putative active site [active] 418127006964 catalytic site [active] 418127006965 DEAD-like helicases superfamily; Region: DEXDc; smart00487 418127006966 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 418127006967 ATP binding site [chemical binding]; other site 418127006968 putative Mg++ binding site [ion binding]; other site 418127006969 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 418127006970 active site 418127006971 8-oxo-dGMP binding site [chemical binding]; other site 418127006972 nudix motif; other site 418127006973 metal binding site [ion binding]; metal-binding site 418127006974 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 418127006975 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-...; Region: PGM2; cd05799 418127006976 active site 418127006977 substrate binding site [chemical binding]; other site 418127006978 metal binding site [ion binding]; metal-binding site 418127006979 H+ Antiporter protein; Region: 2A0121; TIGR00900 418127006980 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 418127006981 legume lectins; Region: lectin_L-type; cl14058 418127006982 homotetramer interaction site [polypeptide binding]; other site 418127006983 carbohydrate binding site [chemical binding]; other site 418127006984 metal binding site [ion binding]; metal-binding site 418127006985 G5 domain; Region: G5; pfam07501 418127006986 G5 domain; Region: G5; pfam07501 418127006987 G5 domain; Region: G5; pfam07501 418127006988 G5 domain; Region: G5; pfam07501 418127006989 G5 domain; Region: G5; pfam07501 418127006990 Gram-positive; Region: pullulan_Gpos; TIGR02102 418127006991 G5 domain; Region: G5; pfam07501 418127006992 104 kDa microneme/rhoptry antigen; Provisional; Region: PTZ00449 418127006993 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 418127006994 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127006995 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127006996 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127006997 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 418127006998 active site 418127006999 tetramer interface [polypeptide binding]; other site 418127007000 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 418127007001 Transposase; Region: DDE_Tnp_ISL3; pfam01610 418127007002 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 418127007003 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 418127007004 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 418127007005 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 418127007006 ribonuclease E; Reviewed; Region: rne; PRK10811 418127007007 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 418127007008 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 418127007009 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 418127007010 gluconate transporter; Region: gntP; TIGR00791 418127007011 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 418127007012 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 418127007013 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 418127007014 Transcriptional regulators [Transcription]; Region: GntR; COG1802 418127007015 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 418127007016 DNA-binding site [nucleotide binding]; DNA binding site 418127007017 FCD domain; Region: FCD; cl11656 418127007018 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 418127007019 DNA binding residues [nucleotide binding] 418127007020 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 418127007021 synthetase active site [active] 418127007022 NTP binding site [chemical binding]; other site 418127007023 metal binding site [ion binding]; metal-binding site 418127007024 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; cl11557 418127007025 Predicted membrane protein [Function unknown]; Region: COG1289 418127007026 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 418127007027 D-galactonate transporter; Region: 2A0114; TIGR00893 418127007028 putative substrate translocation pore; other site 418127007029 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 418127007030 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 418127007031 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 418127007032 Walker A/P-loop; other site 418127007033 ATP binding site [chemical binding]; other site 418127007034 Q-loop/lid; other site 418127007035 ABC transporter signature motif; other site 418127007036 Walker B; other site 418127007037 D-loop; other site 418127007038 H-loop/switch region; other site 418127007039 ABC-2 type transporter; Region: ABC2_membrane; cl11417 418127007040 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 418127007041 Uncharacterized membrane protein [Function unknown]; Region: COG3949 418127007042 Predicted esterase [General function prediction only]; Region: COG0400 418127007043 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 418127007044 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 418127007045 Zn binding site [ion binding]; other site 418127007046 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 418127007047 Zn binding site [ion binding]; other site 418127007048 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127007049 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 418127007050 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 418127007051 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 418127007052 putative metal binding site [ion binding]; other site 418127007053 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 418127007054 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 418127007055 dimer interface [polypeptide binding]; other site 418127007056 FMN binding site [chemical binding]; other site 418127007057 D-lactate dehydrogenase; Provisional; Region: PRK12480 418127007058 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127007059 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 418127007060 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 418127007061 active site 418127007062 motif I; other site 418127007063 motif II; other site 418127007064 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 418127007065 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 418127007066 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 418127007067 Walker A/P-loop; other site 418127007068 ATP binding site [chemical binding]; other site 418127007069 Q-loop/lid; other site 418127007070 ABC transporter signature motif; other site 418127007071 Walker B; other site 418127007072 D-loop; other site 418127007073 H-loop/switch region; other site 418127007074 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 418127007075 active site 418127007076 catalytic site [active] 418127007077 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 418127007078 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 418127007079 Coenzyme A binding pocket [chemical binding]; other site 418127007080 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 418127007081 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 418127007082 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 418127007083 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 418127007084 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 418127007085 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 418127007086 EamA-like transporter family; Region: EamA; cl01037 418127007087 EamA-like transporter family; Region: EamA; cl01037 418127007088 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 418127007089 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 418127007090 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 418127007091 catalytic residues [active] 418127007092 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 418127007093 active site 418127007094 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 418127007095 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 418127007096 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 418127007097 active site turn [active] 418127007098 phosphorylation site [posttranslational modification] 418127007099 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cd00210 418127007100 HPr interaction site; other site 418127007101 glycerol kinase (GK) interaction site [polypeptide binding]; other site 418127007102 active site 418127007103 phosphorylation site [posttranslational modification] 418127007104 pyruvate oxidase; Provisional; Region: PRK08611 418127007105 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 418127007106 PYR/PP interface [polypeptide binding]; other site 418127007107 tetramer interface [polypeptide binding]; other site 418127007108 dimer interface [polypeptide binding]; other site 418127007109 TPP binding site [chemical binding]; other site 418127007110 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 418127007111 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX...; Region: TPP_POX; cd02014 418127007112 TPP-binding site [chemical binding]; other site 418127007113 LrgB-like family; Region: LrgB; cl00596 418127007114 LrgA family; Region: LrgA; cl00608 418127007115 Transcriptional regulator [Transcription]; Region: LysR; COG0583 418127007116 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127007117 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 418127007118 putative dimerization interface [polypeptide binding]; other site 418127007119 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 418127007120 NlpC/P60 family; Region: NLPC_P60; cl11438 418127007121 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 418127007122 homodimer interface [polypeptide binding]; other site 418127007123 NAD binding site [chemical binding]; other site 418127007124 catalytic residues [active] 418127007125 substrate binding pocket [chemical binding]; other site 418127007126 flexible flap; other site 418127007127 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by...; Region: init_cond_enzymes; cd00827 418127007128 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 418127007129 dimer interface [polypeptide binding]; other site 418127007130 active site 418127007131 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 418127007132 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 418127007133 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 418127007134 DNA binding site [nucleotide binding] 418127007135 active site 418127007136 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 418127007137 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 418127007138 Walker A motif; other site 418127007139 ATP binding site [chemical binding]; other site 418127007140 Walker B motif; other site 418127007141 arginine finger; other site 418127007142 UvrB/uvrC motif; Region: UVR; pfam02151 418127007143 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 418127007144 Walker A motif; other site 418127007145 ATP binding site [chemical binding]; other site 418127007146 Walker B motif; other site 418127007147 arginine finger; other site 418127007148 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 418127007149 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 418127007150 Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this...; Region: FeoB; cd01879 418127007151 G1 box; other site 418127007152 GTP/Mg2+ binding site [chemical binding]; other site 418127007153 Switch I region; other site 418127007154 G2 box; other site 418127007155 G3 box; other site 418127007156 Switch II region; other site 418127007157 G4 box; other site 418127007158 G5 box; other site 418127007159 Nucleoside recognition; Region: Gate; cl00486 418127007160 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 418127007161 Nucleoside recognition; Region: Gate; cl00486 418127007162 FeoA domain; Region: FeoA; cl00838 418127007163 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 418127007164 Ammonia monooxygenase; Region: AMO; cl03602 418127007165 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 418127007166 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 418127007167 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 418127007168 Glutamate binding site [chemical binding]; other site 418127007169 homodimer interface [polypeptide binding]; other site 418127007170 NAD binding site [chemical binding]; other site 418127007171 catalytic residues [active] 418127007172 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 418127007173 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 418127007174 active site 418127007175 substrate binding site [chemical binding]; other site 418127007176 trimer interface [polypeptide binding]; other site 418127007177 CoA binding site [chemical binding]; other site 418127007178 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 418127007179 metal-binding site [ion binding] 418127007180 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 418127007181 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 418127007182 metal-binding site [ion binding] 418127007183 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 418127007184 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 418127007185 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 418127007186 metal-binding site [ion binding] 418127007187 D-lactate dehydrogenase; Validated; Region: PRK08605 418127007188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127007189 aspartate aminotransferase; Provisional; Region: PRK07681 418127007190 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 418127007191 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127007192 homodimer interface [polypeptide binding]; other site 418127007193 catalytic residue [active] 418127007194 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 418127007195 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 418127007196 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 418127007197 active site lid residues [active] 418127007198 substrate binding pocket [chemical binding]; other site 418127007199 catalytic residues [active] 418127007200 substrate-Mg2+ binding site; other site 418127007201 aspartate-rich region 1; other site 418127007202 aspartate-rich region 2; other site 418127007203 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 418127007204 active site 418127007205 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 418127007206 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 418127007207 NlpC/P60 family; Region: NLPC_P60; cl11438 418127007208 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 418127007209 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 418127007210 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 418127007211 catalytic triad [active] 418127007212 catalytic triad [active] 418127007213 oxyanion hole [active] 418127007214 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 418127007215 Coenzyme A binding pocket [chemical binding]; other site 418127007216 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 418127007217 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 418127007218 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 418127007219 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 418127007220 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 418127007221 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 418127007222 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 418127007223 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 418127007224 NmrA-like family; Region: NmrA; pfam05368 418127007225 NADP binding site [chemical binding]; other site 418127007226 active site 418127007227 regulatory binding site [polypeptide binding]; other site 418127007228 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 418127007229 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 418127007230 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 418127007231 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 418127007232 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127007233 NAD(P) binding site [chemical binding]; other site 418127007234 active site 418127007235 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 418127007236 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 418127007237 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 418127007238 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 418127007239 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 418127007240 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 418127007241 Nucleoside recognition; Region: Gate; cl00486 418127007242 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 418127007243 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 418127007244 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 418127007245 Phosphotransferase enzyme family; Region: APH; pfam01636 418127007246 active site 418127007247 substrate binding site [chemical binding]; other site 418127007248 ATP binding site [chemical binding]; other site 418127007249 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_2_like; cd04738 418127007250 quinone interaction residues [chemical binding]; other site 418127007251 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 418127007252 active site 418127007253 catalytic residues [active] 418127007254 FMN binding site [chemical binding]; other site 418127007255 substrate binding site [chemical binding]; other site 418127007256 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 418127007257 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 418127007258 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 418127007259 dimer interface [polypeptide binding]; other site 418127007260 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 418127007261 Predicted acyl esterases [General function prediction only]; Region: COG2936 418127007262 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 418127007263 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 418127007264 active site 418127007265 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 418127007266 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 418127007267 tetramerization interface [polypeptide binding]; other site 418127007268 active site 418127007269 pantoate--beta-alanine ligase; Region: panC; TIGR00018 418127007270 Pantoate-beta-alanine ligase; Region: PanC; cd00560 418127007271 active site 418127007272 ATP-binding site [chemical binding]; other site 418127007273 pantoate-binding site; other site 418127007274 HXXH motif; other site 418127007275 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 418127007276 active site 418127007277 oligomerization interface [polypeptide binding]; other site 418127007278 metal binding site [ion binding]; metal-binding site 418127007279 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 418127007280 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 418127007281 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 418127007282 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 418127007283 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 418127007284 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 418127007285 tetramer (dimer of dimers) interface [polypeptide binding]; other site 418127007286 NAD binding site [chemical binding]; other site 418127007287 dimer interface [polypeptide binding]; other site 418127007288 substrate binding site [chemical binding]; other site 418127007289 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 418127007290 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 418127007291 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 418127007292 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 418127007293 inhibitor-cofactor binding pocket; inhibition site 418127007294 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127007295 catalytic residue [active] 418127007296 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 418127007297 catalytic residue [active] 418127007298 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 418127007299 Predicted dehydrogenase [General function prediction only]; Region: COG0579 418127007300 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 418127007301 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 418127007302 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 418127007303 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 418127007304 choline dehydrogenase; Validated; Region: PRK02106 418127007305 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 418127007306 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 418127007307 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 418127007308 tetramerization interface [polypeptide binding]; other site 418127007309 NAD(P) binding site [chemical binding]; other site 418127007310 catalytic residues [active] 418127007311 Predicted transcriptional regulators [Transcription]; Region: COG1510 418127007312 BCCT family transporter; Region: BCCT; cl00569 418127007313 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 418127007314 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 418127007315 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 418127007316 Class III ribonucleotide reductase; Region: RNR_III; cd01675 418127007317 effector binding site; other site 418127007318 active site 418127007319 Zn binding site [ion binding]; other site 418127007320 glycine loop; other site 418127007321 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 418127007322 Citrate transporter; Region: CitMHS; pfam03600 418127007323 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 418127007324 precorrin-2 dehydrogenase; Validated; Region: PRK06719 418127007325 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 418127007326 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 418127007327 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 418127007328 FAD binding pocket [chemical binding]; other site 418127007329 FAD binding motif [chemical binding]; other site 418127007330 catalytic residues [active] 418127007331 NAD binding pocket [chemical binding]; other site 418127007332 phosphate binding motif [ion binding]; other site 418127007333 beta-alpha-beta structure motif; other site 418127007334 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340 418127007335 catalytic residues [active] 418127007336 dimer interface [polypeptide binding]; other site 418127007337 FtsX-like permease family; Region: FtsX; pfam02687 418127007338 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 418127007339 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 418127007340 Walker A/P-loop; other site 418127007341 ATP binding site [chemical binding]; other site 418127007342 Q-loop/lid; other site 418127007343 ABC transporter signature motif; other site 418127007344 Walker B; other site 418127007345 D-loop; other site 418127007346 H-loop/switch region; other site 418127007347 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 418127007348 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 418127007349 ATP binding site [chemical binding]; other site 418127007350 Mg2+ binding site [ion binding]; other site 418127007351 G-X-G motif; other site 418127007352 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 418127007353 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 418127007354 active site 418127007355 phosphorylation site [posttranslational modification] 418127007356 intermolecular recognition site; other site 418127007357 dimerization interface [polypeptide binding]; other site 418127007358 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 418127007359 DNA binding site [nucleotide binding] 418127007360 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH...; Region: alkPPc; cd00016 418127007361 dimer interface [polypeptide binding]; other site 418127007362 Alkaline phosphatase homologues; Region: alkPPc; smart00098 418127007363 active site 418127007364 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH...; Region: alkPPc; cl12039 418127007365 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127007366 Predicted esterase [General function prediction only]; Region: COG0627 418127007367 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 418127007368 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 418127007369 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 418127007370 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 418127007371 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 418127007372 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 418127007373 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127007374 carbamate kinase; Reviewed; Region: PRK12686 418127007375 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 418127007376 putative substrate binding site [chemical binding]; other site 418127007377 nucleotide binding site [chemical binding]; other site 418127007378 nucleotide binding site [chemical binding]; other site 418127007379 homodimer interface [polypeptide binding]; other site 418127007380 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 418127007381 ornithine carbamoyltransferase; Validated; Region: PRK02102 418127007382 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 418127007383 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 418127007384 Amidinotransferase; Region: Amidinotransf; cl12043 418127007385 Arginine deiminase [Amino acid transport and metabolism]; Region: ArcA; COG2235 418127007386 Arginine repressor [Transcription]; Region: ArgR; COG1438 418127007387 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 418127007388 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 418127007389 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 418127007390 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 418127007391 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 418127007392 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 418127007393 active site 418127007394 Zn binding site [ion binding]; other site 418127007395 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 418127007396 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127007397 PRD domain; Region: PRD; pfam00874 418127007398 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 418127007399 P-loop; other site 418127007400 active site 418127007401 phosphorylation site [posttranslational modification] 418127007402 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 418127007403 active site 418127007404 phosphorylation site [posttranslational modification] 418127007405 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 418127007406 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 418127007407 P-loop; other site 418127007408 active site 418127007409 phosphorylation site [posttranslational modification] 418127007410 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 418127007411 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 418127007412 active site 418127007413 phosphorylation site [posttranslational modification] 418127007414 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 418127007415 mannose-6-phosphate isomerase; Provisional; Region: PRK15131; cl14659 418127007416 Predicted membrane protein [Function unknown]; Region: COG1511 418127007417 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 418127007418 ABC-2 type transporter; Region: ABC2_membrane; cl11417 418127007419 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 418127007420 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 418127007421 NlpC/P60 family; Region: NLPC_P60; cl11438 418127007422 Isochorismatase family; Region: Isochorismatase; pfam00857 418127007423 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 418127007424 catalytic triad [active] 418127007425 conserved cis-peptide bond; other site 418127007426 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 418127007427 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 418127007428 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 418127007429 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 418127007430 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 418127007431 accessory Sec system translocase SecA2; Region: secA2; TIGR03714 418127007432 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 418127007433 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 418127007434 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 418127007435 nucleotide binding region [chemical binding]; other site 418127007436 ATP-binding site [chemical binding]; other site 418127007437 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 418127007438 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 418127007439 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 418127007440 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 418127007441 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 418127007442 SecY translocase; Region: SecY; pfam00344 418127007443 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 418127007444 legume lectins; Region: lectin_L-type; cd01951 418127007445 homotetramer interaction site [polypeptide binding]; other site 418127007446 carbohydrate binding site [chemical binding]; other site 418127007447 metal binding site [ion binding]; metal-binding site 418127007448 Putative Ig domain; Region: He_PIG; cl09256 418127007449 Flavin Reductases; Region: FlaRed; cl00801 418127007450 Flavin Reductases; Region: FlaRed; cl00801 418127007451 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 418127007452 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 418127007453 Coenzyme A binding pocket [chemical binding]; other site 418127007454 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 418127007455 PHP domain; Region: PHP; pfam02811 418127007456 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 418127007457 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 418127007458 Chain length determinant protein; Region: Wzz; cl01623 418127007459 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 418127007460 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 418127007461 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 418127007462 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 418127007463 DXD motif; other site 418127007464 intracellular adhesion protein D; Region: PIA_icaD; TIGR03932 418127007465 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 418127007466 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 418127007467 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 418127007468 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 418127007469 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 418127007470 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 418127007471 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 418127007472 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 418127007473 Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107 418127007474 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731 418127007475 substrate binding site [chemical binding]; other site 418127007476 glutamase interaction surface [polypeptide binding]; other site 418127007477 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732 418127007478 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 418127007479 catalytic residues [active] 418127007480 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 418127007481 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 418127007482 putative active site [active] 418127007483 oxyanion strand; other site 418127007484 catalytic triad [active] 418127007485 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 418127007486 putative active site pocket [active] 418127007487 4-fold oligomerization interface [polypeptide binding]; other site 418127007488 metal binding residues [ion binding]; metal-binding site 418127007489 3-fold/trimer interface [polypeptide binding]; other site 418127007490 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 418127007491 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 418127007492 pyridoxal 5'-phosphate binding site [chemical binding]; other site 418127007493 homodimer interface [polypeptide binding]; other site 418127007494 catalytic residue [active] 418127007495 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 418127007496 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572 418127007497 NAD binding site [chemical binding]; other site 418127007498 dimerization interface [polypeptide binding]; other site 418127007499 product binding site; other site 418127007500 substrate binding site [chemical binding]; other site 418127007501 zinc binding site [ion binding]; other site 418127007502 catalytic residues [active] 418127007503 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 418127007504 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 418127007505 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 418127007506 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 418127007507 Cobalt transport protein; Region: CbiQ; cl00463 418127007508 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 418127007509 Walker A/P-loop; other site 418127007510 ATP binding site [chemical binding]; other site 418127007511 Q-loop/lid; other site 418127007512 ABC transporter signature motif; other site 418127007513 Walker B; other site 418127007514 D-loop; other site 418127007515 H-loop/switch region; other site 418127007516 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 418127007517 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 418127007518 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 418127007519 Walker A/P-loop; other site 418127007520 ATP binding site [chemical binding]; other site 418127007521 Q-loop/lid; other site 418127007522 ABC transporter signature motif; other site 418127007523 Walker B; other site 418127007524 D-loop; other site 418127007525 H-loop/switch region; other site 418127007526 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 418127007527 Uncharacterized conserved protein [Function unknown]; Region: COG1912 418127007528 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 418127007529 YceI-like domain; Region: YceI; cl01001 418127007530 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 418127007531 Strictosidine synthase; Region: Str_synth; pfam03088 418127007532 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 418127007533 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 418127007534 active site residue [active] 418127007535 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 418127007536 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 418127007537 putative substrate binding pocket [chemical binding]; other site 418127007538 AC domain interface; other site 418127007539 catalytic triad [active] 418127007540 AB domain interface; other site 418127007541 interchain disulfide; other site 418127007542 hypothetical protein; Validated; Region: PRK07668 418127007543 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 418127007544 DinB superfamily; Region: DinB_2; cl00986 418127007545 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 418127007546 transmembrane helices; other site 418127007547 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 418127007548 Predicted permeases [General function prediction only]; Region: RarD; COG2962 418127007549 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 418127007550 High-affinity nickel-transport protein; Region: NicO; cl00964 418127007551 N-acetyltransferase; Region: Acetyltransf_2; cl00949 418127007552 Uncharacterized conserved protein [Function unknown]; Region: HdeD; cl01277 418127007553 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 418127007554 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 418127007555 Walker A/P-loop; other site 418127007556 ATP binding site [chemical binding]; other site 418127007557 Q-loop/lid; other site 418127007558 ABC transporter signature motif; other site 418127007559 Walker B; other site 418127007560 D-loop; other site 418127007561 H-loop/switch region; other site 418127007562 FtsX-like permease family; Region: FtsX; pfam02687 418127007563 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 418127007564 DNA-binding site [nucleotide binding]; DNA binding site 418127007565 RNA-binding motif; other site 418127007566 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 418127007567 non-specific DNA binding site [nucleotide binding]; other site 418127007568 salt bridge; other site 418127007569 sequence-specific DNA binding site [nucleotide binding]; other site 418127007570 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 418127007571 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 418127007572 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 418127007573 ParB-like nuclease domain; Region: ParBc; cl02129 418127007574 ParB-like partition proteins; Region: parB_part; TIGR00180 418127007575 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 418127007576 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 418127007577 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; cl11520 418127007578 Flavin-dependent tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Cell cycle control, cell division, chromosome partitioning]; Region: GidA; COG0445 418127007579 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 418127007580 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 418127007581 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 418127007582 G1 box; other site 418127007583 GTP/Mg2+ binding site [chemical binding]; other site 418127007584 Switch I region; other site 418127007585 G2 box; other site 418127007586 Switch II region; other site 418127007587 G3 box; other site 418127007588 G4 box; other site 418127007589 G5 box; other site 418127007590 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 418127007591 Ribonuclease P; Region: Ribonuclease_P; cl00457 418127007592 Ribosomal protein L34; Region: Ribosomal_L34; cl00370