-- dump date 20120504_162429 -- class Genbank::misc_feature -- table misc_feature_note -- id note 698737000001 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 698737000002 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 698737000003 Uncharacterized conserved protein [Function unknown]; Region: COG2128 698737000004 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698737000005 putative DNA binding site [nucleotide binding]; other site 698737000006 putative Zn2+ binding site [ion binding]; other site 698737000007 Helix-turn-helix domains; Region: HTH; cl00088 698737000008 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 698737000009 putative catalytic site [active] 698737000010 metal binding site A [ion binding]; metal-binding site 698737000011 phosphate binding site [ion binding]; other site 698737000012 metal binding site C [ion binding]; metal-binding site 698737000013 metal binding site B [ion binding]; metal-binding site 698737000014 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 698737000015 Helix-turn-helix domains; Region: HTH; cl00088 698737000016 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 698737000017 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 698737000018 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 698737000019 NADH(P)-binding; Region: NAD_binding_10; pfam13460 698737000020 putative NAD(P) binding site [chemical binding]; other site 698737000021 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 698737000022 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 698737000023 FMN binding site [chemical binding]; other site 698737000024 active site 698737000025 catalytic residues [active] 698737000026 substrate binding site [chemical binding]; other site 698737000027 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698737000028 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737000029 Walker A/P-loop; other site 698737000030 ATP binding site [chemical binding]; other site 698737000031 Q-loop/lid; other site 698737000032 ABC transporter signature motif; other site 698737000033 Walker B; other site 698737000034 D-loop; other site 698737000035 H-loop/switch region; other site 698737000036 potential frameshift: common BLAST hit: gi|226223712|ref|YP_002757819.1| streptolysin S associated ORF sagB 698737000037 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 698737000038 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 698737000039 putative FMN binding site [chemical binding]; other site 698737000040 bacteriocin biosynthesis cyclodehydratase, SagC family; Region: cyclo_dehy_ocin; TIGR03603 698737000041 YcaO-like family; Region: YcaO; pfam02624 698737000042 Uncharacterized conserved protein [Function unknown]; Region: COG1944; cl09146 698737000043 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698737000044 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698737000045 phosphorylation site [posttranslational modification] 698737000046 dimer interface [polypeptide binding]; other site 698737000047 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737000048 ATP binding site [chemical binding]; other site 698737000049 Mg2+ binding site [ion binding]; other site 698737000050 G-X-G motif; other site 698737000051 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698737000052 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698737000053 active site 698737000054 phosphorylation site [posttranslational modification] 698737000055 intermolecular recognition site; other site 698737000056 dimerization interface [polypeptide binding]; other site 698737000057 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698737000058 DNA binding site [nucleotide binding] 698737000059 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698737000060 ABC-type multidrug transport system, ATPase component. The biological function of this family is not well characterized, but display ABC domains similar to members of ABCA subfamily. ABC transporters are a large family of proteins involved in the...; Region: ABC_drug_resistance_like; cd03264 698737000061 Walker A/P-loop; other site 698737000062 ATP binding site [chemical binding]; other site 698737000063 Q-loop/lid; other site 698737000064 ABC transporter signature motif; other site 698737000065 Walker B; other site 698737000066 D-loop; other site 698737000067 H-loop/switch region; other site 698737000068 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 698737000069 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 698737000070 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 698737000071 CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578 698737000072 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647 698737000073 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684 698737000074 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 698737000075 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 698737000076 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873 698737000077 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873 698737000078 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 698737000079 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 698737000080 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 698737000081 Condensation domain; Region: Condensation; pfam00668 698737000082 peptide synthase; Provisional; Region: PRK12316 698737000083 AMP-binding enzyme; Region: AMP-binding; cl15778 698737000084 Phosphopantetheine attachment site; Region: PP-binding; cl09936 698737000085 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 698737000086 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 698737000087 AMP-binding enzyme; Region: AMP-binding; cl15778 698737000088 acetoacetyl-CoA synthase; Region: ac_ac_CoA_syn; TIGR01217 698737000089 Phosphopantetheine attachment site; Region: PP-binding; cl09936 698737000090 thioester reductase domain; Region: Thioester-redct; TIGR01746 698737000091 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737000092 NAD(P) binding site [chemical binding]; other site 698737000093 active site 698737000094 Protein of unknown function, DUF576; Region: DUF576; cl04553 698737000095 Protein of unknown function, DUF576; Region: DUF576; cl04553 698737000096 Protein of unknown function, DUF576; Region: DUF576; cl04553 698737000097 Protein of unknown function, DUF576; Region: DUF576; cl04553 698737000098 Protein of unknown function, DUF576; Region: DUF576; cl04553 698737000099 Protein of unknown function, DUF576; Region: DUF576; cl04553 698737000100 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 698737000101 nucleophilic elbow; other site 698737000102 catalytic triad; other site 698737000103 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 698737000104 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 698737000105 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698737000106 NAD binding site [chemical binding]; other site 698737000107 dimer interface [polypeptide binding]; other site 698737000108 substrate binding site [chemical binding]; other site 698737000109 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 698737000110 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698737000111 DNA-binding site [nucleotide binding]; DNA binding site 698737000112 UTRA domain; Region: UTRA; cl01230 698737000113 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 698737000114 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 698737000115 dimer interface [polypeptide binding]; other site 698737000116 active site 698737000117 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 698737000118 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 698737000119 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 698737000120 active site 698737000121 phosphorylation site [posttranslational modification] 698737000122 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 698737000123 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 698737000124 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 698737000125 active pocket/dimerization site; other site 698737000126 active site 698737000127 phosphorylation site [posttranslational modification] 698737000128 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698737000129 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698737000130 active site 698737000131 phosphorylation site [posttranslational modification] 698737000132 intermolecular recognition site; other site 698737000133 dimerization interface [polypeptide binding]; other site 698737000134 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698737000135 DNA binding site [nucleotide binding] 698737000136 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 698737000137 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 698737000138 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 698737000139 Ligand Binding Site [chemical binding]; other site 698737000140 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698737000141 dimer interface [polypeptide binding]; other site 698737000142 phosphorylation site [posttranslational modification] 698737000143 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737000144 ATP binding site [chemical binding]; other site 698737000145 Mg2+ binding site [ion binding]; other site 698737000146 G-X-G motif; other site 698737000147 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 698737000148 potassium-transporting ATPase subunit B; Provisional; Region: PRK14010 698737000149 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698737000150 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 698737000151 K+-transporting ATPase, c chain; Region: KdpC; cl00944 698737000152 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 698737000153 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cl02760 698737000154 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 698737000155 heme-binding site [chemical binding]; other site 698737000156 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 698737000157 Cobalt transport protein; Region: CbiQ; cl00463 698737000158 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698737000159 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 698737000160 Walker A/P-loop; other site 698737000161 ATP binding site [chemical binding]; other site 698737000162 Q-loop/lid; other site 698737000163 ABC transporter signature motif; other site 698737000164 Walker B; other site 698737000165 D-loop; other site 698737000166 H-loop/switch region; other site 698737000167 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698737000168 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737000169 Walker A/P-loop; other site 698737000170 ATP binding site [chemical binding]; other site 698737000171 Q-loop/lid; other site 698737000172 ABC transporter signature motif; other site 698737000173 Walker B; other site 698737000174 D-loop; other site 698737000175 H-loop/switch region; other site 698737000176 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 698737000177 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 698737000178 heme-binding site [chemical binding]; other site 698737000179 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 698737000180 heme-binding site [chemical binding]; other site 698737000181 heme uptake protein IsdC; Region: IsdC; TIGR03656 698737000182 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 698737000183 heme-binding site [chemical binding]; other site 698737000184 sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068 698737000185 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 698737000186 heme-binding site [chemical binding]; other site 698737000187 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 698737000188 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698737000189 intersubunit interface [polypeptide binding]; other site 698737000190 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698737000191 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698737000192 ABC-ATPase subunit interface; other site 698737000193 dimer interface [polypeptide binding]; other site 698737000194 putative PBP binding regions; other site 698737000195 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698737000196 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698737000197 Walker A/P-loop; other site 698737000198 ATP binding site [chemical binding]; other site 698737000199 Q-loop/lid; other site 698737000200 ABC transporter signature motif; other site 698737000201 Walker B; other site 698737000202 D-loop; other site 698737000203 H-loop/switch region; other site 698737000204 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 698737000205 active site 698737000206 catalytic site [active] 698737000207 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 698737000208 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 698737000209 NlpC/P60 family; Region: NLPC_P60; cl11438 698737000210 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698737000211 ABC-ATPase subunit interface; other site 698737000212 dimer interface [polypeptide binding]; other site 698737000213 putative PBP binding regions; other site 698737000214 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698737000215 ABC-ATPase subunit interface; other site 698737000216 dimer interface [polypeptide binding]; other site 698737000217 putative PBP binding regions; other site 698737000218 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 698737000219 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698737000220 siderophore binding site; other site 698737000221 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 698737000222 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 698737000223 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698737000224 Coenzyme A binding pocket [chemical binding]; other site 698737000225 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 698737000226 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698737000227 Helix-turn-helix domains; Region: HTH; cl00088 698737000228 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 698737000229 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737000230 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 698737000231 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698737000232 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 698737000233 Walker A/P-loop; other site 698737000234 ATP binding site [chemical binding]; other site 698737000235 Q-loop/lid; other site 698737000236 ABC transporter signature motif; other site 698737000237 Walker B; other site 698737000238 D-loop; other site 698737000239 H-loop/switch region; other site 698737000240 TOBE domain; Region: TOBE_2; cl01440 698737000241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698737000242 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698737000243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737000244 dimer interface [polypeptide binding]; other site 698737000245 conserved gate region; other site 698737000246 putative PBP binding loops; other site 698737000247 ABC-ATPase subunit interface; other site 698737000248 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 698737000249 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698737000250 putative active site [active] 698737000251 putative metal binding site [ion binding]; other site 698737000252 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 698737000253 MatE; Region: MatE; cl10513 698737000254 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 698737000255 potassium-transporting ATPase subunit B; Provisional; Region: PRK14010 698737000256 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698737000257 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 698737000258 K+-transporting ATPase, c chain; Region: KdpC; cl00944 698737000259 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 698737000260 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cl02760 698737000261 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 698737000262 heme-binding site [chemical binding]; other site 698737000263 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 698737000264 Cobalt transport protein; Region: CbiQ; cl00463 698737000265 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698737000266 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 698737000267 Walker A/P-loop; other site 698737000268 ATP binding site [chemical binding]; other site 698737000269 Q-loop/lid; other site 698737000270 ABC transporter signature motif; other site 698737000271 Walker B; other site 698737000272 D-loop; other site 698737000273 H-loop/switch region; other site 698737000274 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698737000275 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737000276 Walker A/P-loop; other site 698737000277 ATP binding site [chemical binding]; other site 698737000278 Q-loop/lid; other site 698737000279 ABC transporter signature motif; other site 698737000280 Walker B; other site 698737000281 D-loop; other site 698737000282 H-loop/switch region; other site 698737000283 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 698737000284 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 698737000285 heme-binding site [chemical binding]; other site 698737000286 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 698737000287 heme-binding site [chemical binding]; other site 698737000288 heme uptake protein IsdC; Region: IsdC; TIGR03656 698737000289 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 698737000290 heme-binding site [chemical binding]; other site 698737000291 sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068 698737000292 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 698737000293 heme-binding site [chemical binding]; other site 698737000294 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 698737000295 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698737000296 intersubunit interface [polypeptide binding]; other site 698737000297 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698737000298 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698737000299 ABC-ATPase subunit interface; other site 698737000300 dimer interface [polypeptide binding]; other site 698737000301 putative PBP binding regions; other site 698737000302 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698737000303 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698737000304 Walker A/P-loop; other site 698737000305 ATP binding site [chemical binding]; other site 698737000306 Q-loop/lid; other site 698737000307 ABC transporter signature motif; other site 698737000308 Walker B; other site 698737000309 D-loop; other site 698737000310 H-loop/switch region; other site 698737000311 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 698737000312 active site 698737000313 catalytic site [active] 698737000314 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 698737000315 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 698737000316 NlpC/P60 family; Region: NLPC_P60; cl11438 698737000317 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698737000318 ABC-ATPase subunit interface; other site 698737000319 dimer interface [polypeptide binding]; other site 698737000320 putative PBP binding regions; other site 698737000321 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698737000322 ABC-ATPase subunit interface; other site 698737000323 dimer interface [polypeptide binding]; other site 698737000324 putative PBP binding regions; other site 698737000325 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 698737000326 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698737000327 siderophore binding site; other site 698737000328 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 698737000329 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 698737000330 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698737000331 Coenzyme A binding pocket [chemical binding]; other site 698737000332 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 698737000333 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698737000334 Helix-turn-helix domains; Region: HTH; cl00088 698737000335 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 698737000336 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737000337 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 698737000338 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698737000339 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 698737000340 Walker A/P-loop; other site 698737000341 ATP binding site [chemical binding]; other site 698737000342 Q-loop/lid; other site 698737000343 ABC transporter signature motif; other site 698737000344 Walker B; other site 698737000345 D-loop; other site 698737000346 H-loop/switch region; other site 698737000347 TOBE domain; Region: TOBE_2; cl01440 698737000348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698737000349 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698737000350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737000351 dimer interface [polypeptide binding]; other site 698737000352 conserved gate region; other site 698737000353 putative PBP binding loops; other site 698737000354 ABC-ATPase subunit interface; other site 698737000355 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 698737000356 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698737000357 putative active site [active] 698737000358 putative metal binding site [ion binding]; other site 698737000359 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 698737000360 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 698737000361 MatE; Region: MatE; cl10513 698737000362 MatE; Region: MatE; cl10513 698737000363 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698737000364 Helix-turn-helix domains; Region: HTH; cl00088 698737000365 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 698737000366 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698737000367 catalytic core [active] 698737000368 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 698737000369 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698737000370 dimer interface [polypeptide binding]; other site 698737000371 phosphorylation site [posttranslational modification] 698737000372 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737000373 ATP binding site [chemical binding]; other site 698737000374 Mg2+ binding site [ion binding]; other site 698737000375 G-X-G motif; other site 698737000376 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698737000377 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698737000378 active site 698737000379 phosphorylation site [posttranslational modification] 698737000380 intermolecular recognition site; other site 698737000381 dimerization interface [polypeptide binding]; other site 698737000382 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698737000383 DNA binding site [nucleotide binding] 698737000384 DoxX; Region: DoxX; cl00976 698737000385 Electron transfer DM13; Region: DM13; cl02735 698737000386 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698737000387 Helix-turn-helix domains; Region: HTH; cl00088 698737000388 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 698737000389 dimerization interface [polypeptide binding]; other site 698737000390 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698737000391 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737000392 Walker A/P-loop; other site 698737000393 ATP binding site [chemical binding]; other site 698737000394 Q-loop/lid; other site 698737000395 ABC transporter signature motif; other site 698737000396 Walker B; other site 698737000397 D-loop; other site 698737000398 H-loop/switch region; other site 698737000399 TOBE domain; Region: TOBE_2; cl01440 698737000400 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 698737000401 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698737000402 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 698737000403 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737000404 dimer interface [polypeptide binding]; other site 698737000405 conserved gate region; other site 698737000406 putative PBP binding loops; other site 698737000407 ABC-ATPase subunit interface; other site 698737000408 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737000409 dimer interface [polypeptide binding]; other site 698737000410 conserved gate region; other site 698737000411 putative PBP binding loops; other site 698737000412 ABC-ATPase subunit interface; other site 698737000413 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 698737000414 active site 698737000415 metal binding site [ion binding]; metal-binding site 698737000416 Helix-turn-helix domains; Region: HTH; cl00088 698737000417 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 698737000418 Bacterial transcriptional regulator; Region: IclR; pfam01614 698737000419 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 698737000420 substrate binding site [chemical binding]; other site 698737000421 ATP binding site [chemical binding]; other site 698737000422 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 698737000423 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 698737000424 active site 698737000425 intersubunit interface [polypeptide binding]; other site 698737000426 catalytic residue [active] 698737000427 galactonate dehydratase; Provisional; Region: PRK14017 698737000428 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 698737000429 putative active site pocket [active] 698737000430 putative metal binding site [ion binding]; other site 698737000431 gluconate transporter; Region: gntP; TIGR00791 698737000432 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 698737000433 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 698737000434 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 698737000435 DNA binding residues [nucleotide binding] 698737000436 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 698737000437 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 698737000438 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 698737000439 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 698737000440 active site 698737000441 dimer interface [polypeptide binding]; other site 698737000442 motif 1; other site 698737000443 motif 2; other site 698737000444 motif 3; other site 698737000445 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 698737000446 anticodon binding site; other site 698737000447 hypothetical protein; Provisional; Region: PRK06184 698737000448 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737000449 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737000450 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 698737000451 stage V sporulation protein K; Region: spore_V_K; TIGR02881 698737000452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698737000453 Walker A motif; other site 698737000454 ATP binding site [chemical binding]; other site 698737000455 Walker B motif; other site 698737000456 arginine finger; other site 698737000457 stage V sporulation protein K; Region: spore_V_K; TIGR02881 698737000458 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698737000459 Walker A motif; other site 698737000460 ATP binding site [chemical binding]; other site 698737000461 Walker B motif; other site 698737000462 arginine finger; other site 698737000463 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698737000464 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698737000465 active site 698737000466 motif I; other site 698737000467 motif II; other site 698737000468 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 698737000469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737000470 benzoate transport; Region: 2A0115; TIGR00895 698737000471 putative substrate translocation pore; other site 698737000472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737000473 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698737000474 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 698737000475 substrate binding site [chemical binding]; other site 698737000476 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698737000477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737000478 dimer interface [polypeptide binding]; other site 698737000479 conserved gate region; other site 698737000480 putative PBP binding loops; other site 698737000481 ABC-ATPase subunit interface; other site 698737000482 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698737000483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737000484 dimer interface [polypeptide binding]; other site 698737000485 conserved gate region; other site 698737000486 putative PBP binding loops; other site 698737000487 ABC-ATPase subunit interface; other site 698737000488 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 698737000489 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 698737000490 Walker A/P-loop; other site 698737000491 ATP binding site [chemical binding]; other site 698737000492 Q-loop/lid; other site 698737000493 ABC transporter signature motif; other site 698737000494 Walker B; other site 698737000495 D-loop; other site 698737000496 H-loop/switch region; other site 698737000497 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 698737000498 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 698737000499 Walker A/P-loop; other site 698737000500 ATP binding site [chemical binding]; other site 698737000501 Q-loop/lid; other site 698737000502 ABC transporter signature motif; other site 698737000503 Walker B; other site 698737000504 D-loop; other site 698737000505 H-loop/switch region; other site 698737000506 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698737000507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737000508 putative substrate translocation pore; other site 698737000509 Peptidase M30; Region: Peptidase_M30; pfam10460 698737000510 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 698737000511 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 698737000512 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 698737000513 conserved cys residue [active] 698737000514 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 698737000515 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 698737000516 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 698737000517 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 698737000518 catalytic triad [active] 698737000519 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 698737000520 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 698737000521 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 698737000522 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 698737000523 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 698737000524 active site turn [active] 698737000525 phosphorylation site [posttranslational modification] 698737000526 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 698737000527 HPr interaction site; other site 698737000528 glycerol kinase (GK) interaction site [polypeptide binding]; other site 698737000529 active site 698737000530 phosphorylation site [posttranslational modification] 698737000531 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698737000532 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 698737000533 intersubunit interface [polypeptide binding]; other site 698737000534 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 698737000535 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 698737000536 potential frameshift: common BLAST hit: gi|224477927|ref|YP_002635533.1| penicillin binding protein 4 698737000537 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 698737000538 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 698737000539 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 698737000540 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 698737000541 Helix-turn-helix domains; Region: HTH; cl00088 698737000542 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 698737000543 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 698737000544 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698737000545 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 698737000546 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 698737000547 NADP binding site [chemical binding]; other site 698737000548 putative substrate binding site [chemical binding]; other site 698737000549 active site 698737000550 Predicted membrane protein [Function unknown]; Region: COG3212 698737000551 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 698737000552 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 698737000553 Pyruvate formate lyase 1; Region: PFL1; cd01678 698737000554 coenzyme A binding site [chemical binding]; other site 698737000555 active site 698737000556 catalytic residues [active] 698737000557 glycine loop; other site 698737000558 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 698737000559 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698737000560 FeS/SAM binding site; other site 698737000561 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698737000562 dimerization interface [polypeptide binding]; other site 698737000563 putative DNA binding site [nucleotide binding]; other site 698737000564 putative Zn2+ binding site [ion binding]; other site 698737000565 arsenical pump membrane protein; Provisional; Region: PRK15445 698737000566 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 698737000567 transmembrane helices; other site 698737000568 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 698737000569 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737000570 Walker A/P-loop; other site 698737000571 ATP binding site [chemical binding]; other site 698737000572 Q-loop/lid; other site 698737000573 ABC transporter signature motif; other site 698737000574 Walker B; other site 698737000575 D-loop; other site 698737000576 H-loop/switch region; other site 698737000577 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 698737000578 acetoin reductases; Region: 23BDH; TIGR02415 698737000579 NAD binding site [chemical binding]; other site 698737000580 homotetramer interface [polypeptide binding]; other site 698737000581 homodimer interface [polypeptide binding]; other site 698737000582 active site 698737000583 substrate binding site [chemical binding]; other site 698737000584 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 698737000585 DNA-binding site [nucleotide binding]; DNA binding site 698737000586 RNA-binding motif; other site 698737000587 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 698737000588 Helix-turn-helix domains; Region: HTH; cl00088 698737000589 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 698737000590 Predicted acyl esterases [General function prediction only]; Region: COG2936 698737000591 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 698737000592 Predicted membrane protein [Function unknown]; Region: COG2311 698737000593 Protein of unknown function (DUF418); Region: DUF418; cl12135 698737000594 Protein of unknown function (DUF418); Region: DUF418; cl12135 698737000595 TspO/MBR family; Region: TspO_MBR; cl01379 698737000596 phytoene desaturase; Region: crtI_fam; TIGR02734 698737000597 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737000598 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cl00358 698737000599 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 698737000600 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 698737000601 active site 698737000602 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737000603 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 698737000604 active site lid residues [active] 698737000605 substrate binding pocket [chemical binding]; other site 698737000606 catalytic residues [active] 698737000607 substrate-Mg2+ binding site; other site 698737000608 aspartate-rich region 1; other site 698737000609 aspartate-rich region 2; other site 698737000610 phytoene desaturase; Region: crtI_fam; TIGR02734 698737000611 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737000612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737000613 putative substrate translocation pore; other site 698737000614 MepB protein; Region: MepB; cl01985 698737000615 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698737000616 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737000617 Walker A/P-loop; other site 698737000618 ATP binding site [chemical binding]; other site 698737000619 Q-loop/lid; other site 698737000620 ABC transporter signature motif; other site 698737000621 Walker B; other site 698737000622 D-loop; other site 698737000623 H-loop/switch region; other site 698737000624 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 698737000625 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698737000626 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698737000627 S-adenosylmethionine binding site [chemical binding]; other site 698737000628 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 698737000629 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698737000630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698737000631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737000632 dimer interface [polypeptide binding]; other site 698737000633 conserved gate region; other site 698737000634 putative PBP binding loops; other site 698737000635 ABC-ATPase subunit interface; other site 698737000636 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 698737000637 Q-loop/lid; other site 698737000638 ABC transporter signature motif; other site 698737000639 Walker B; other site 698737000640 D-loop; other site 698737000641 H-loop/switch region; other site 698737000642 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698737000643 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 698737000644 Walker A/P-loop; other site 698737000645 ATP binding site [chemical binding]; other site 698737000646 Q-loop/lid; other site 698737000647 ABC transporter signature motif; other site 698737000648 Walker B; other site 698737000649 D-loop; other site 698737000650 H-loop/switch region; other site 698737000651 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 698737000652 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 698737000653 dimer interface [polypeptide binding]; other site 698737000654 PYR/PP interface [polypeptide binding]; other site 698737000655 TPP binding site [chemical binding]; other site 698737000656 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 698737000657 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 698737000658 TPP-binding site [chemical binding]; other site 698737000659 dimer interface [polypeptide binding]; other site 698737000660 Helix-turn-helix domains; Region: HTH; cl00088 698737000661 transcriptional regulator SlyA; Provisional; Region: PRK03573 698737000662 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 698737000663 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737000664 Walker A/P-loop; other site 698737000665 ATP binding site [chemical binding]; other site 698737000666 Q-loop/lid; other site 698737000667 ABC transporter signature motif; other site 698737000668 Walker B; other site 698737000669 D-loop; other site 698737000670 H-loop/switch region; other site 698737000671 ABC-2 type transporter; Region: ABC2_membrane; cl11417 698737000672 YceI-like domain; Region: YceI; cl01001 698737000673 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 698737000674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737000675 putative substrate translocation pore; other site 698737000676 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 698737000677 N-acetyltransferase; Region: Acetyltransf_2; cl00949 698737000678 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 698737000679 classical (c) SDRs; Region: SDR_c; cd05233 698737000680 NAD(P) binding site [chemical binding]; other site 698737000681 active site 698737000682 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 698737000683 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 698737000684 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 698737000685 active site turn [active] 698737000686 phosphorylation site [posttranslational modification] 698737000687 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 698737000688 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737000689 NAD(P) binding site [chemical binding]; other site 698737000690 active site 698737000691 Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080 698737000692 Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893 698737000693 putative catalytic cysteine [active] 698737000694 AMP-binding enzyme; Region: AMP-binding; cl15778 698737000695 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 698737000696 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 698737000697 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737000698 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 698737000699 putative active site [active] 698737000700 putative FMN binding site [chemical binding]; other site 698737000701 putative substrate binding site [chemical binding]; other site 698737000702 putative catalytic residue [active] 698737000703 FMN-binding domain; Region: FMN_bind; cl01081 698737000704 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 698737000705 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737000706 ApbE family; Region: ApbE; cl00643 698737000707 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 698737000708 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 698737000709 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698737000710 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737000711 homodimer interface [polypeptide binding]; other site 698737000712 catalytic residue [active] 698737000713 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 698737000714 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737000715 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698737000716 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698737000717 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 698737000718 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 698737000719 tetramer interface [polypeptide binding]; other site 698737000720 TPP-binding site [chemical binding]; other site 698737000721 heterodimer interface [polypeptide binding]; other site 698737000722 phosphorylation loop region [posttranslational modification] 698737000723 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 698737000724 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 698737000725 alpha subunit interface [polypeptide binding]; other site 698737000726 TPP binding site [chemical binding]; other site 698737000727 heterodimer interface [polypeptide binding]; other site 698737000728 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698737000729 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 698737000730 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698737000731 E3 interaction surface; other site 698737000732 lipoyl attachment site [posttranslational modification]; other site 698737000733 e3 binding domain; Region: E3_binding; pfam02817 698737000734 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 698737000735 Helix-turn-helix domains; Region: HTH; cl00088 698737000736 hypothetical protein; Validated; Region: PRK07668 698737000737 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 698737000738 Helix-turn-helix domains; Region: HTH; cl00088 698737000739 PRD domain; Region: PRD; cl15445 698737000740 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 698737000741 P-loop; other site 698737000742 active site 698737000743 phosphorylation site [posttranslational modification] 698737000744 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 698737000745 active site 698737000746 phosphorylation site [posttranslational modification] 698737000747 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 698737000748 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 698737000749 P-loop; other site 698737000750 active site 698737000751 phosphorylation site [posttranslational modification] 698737000752 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 698737000753 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 698737000754 active site 698737000755 phosphorylation site [posttranslational modification] 698737000756 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 698737000757 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 698737000758 NMT1/THI5 like; Region: NMT1; pfam09084 698737000759 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698737000760 non-specific DNA binding site [nucleotide binding]; other site 698737000761 salt bridge; other site 698737000762 sequence-specific DNA binding site [nucleotide binding]; other site 698737000763 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 698737000764 ornithine decarboxylase; Provisional; Region: PRK13578 698737000765 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 698737000766 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698737000767 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698737000768 catalytic residue [active] 698737000769 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 698737000770 putrescine transporter; Provisional; Region: potE; PRK10655 698737000771 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 698737000772 Cation efflux family; Region: Cation_efflux; cl00316 698737000773 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 698737000774 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698737000775 non-specific DNA binding site [nucleotide binding]; other site 698737000776 salt bridge; other site 698737000777 sequence-specific DNA binding site [nucleotide binding]; other site 698737000778 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 698737000779 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 698737000780 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 698737000781 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cd00296 698737000782 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 698737000783 putative ADP-ribose binding site [chemical binding]; other site 698737000784 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 698737000785 lipoyl attachment site [posttranslational modification]; other site 698737000786 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 698737000787 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 698737000788 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 698737000789 putative active site [active] 698737000790 putative FMN binding site [chemical binding]; other site 698737000791 putative substrate binding site [chemical binding]; other site 698737000792 putative catalytic residue [active] 698737000793 BCCT family transporter; Region: BCCT; cl00569 698737000794 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 698737000795 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 698737000796 active site 698737000797 dimer interface [polypeptide binding]; other site 698737000798 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 698737000799 active site 698737000800 trimer interface [polypeptide binding]; other site 698737000801 allosteric site; other site 698737000802 active site lid [active] 698737000803 hexamer (dimer of trimers) interface [polypeptide binding]; other site 698737000804 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 698737000805 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 698737000806 putative active site cavity [active] 698737000807 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 698737000808 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 698737000809 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 698737000810 putative active site [active] 698737000811 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698737000812 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 698737000813 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 698737000814 N-acetylneuraminate lyase; Region: nanA; TIGR00683 698737000815 inhibitor site; inhibition site 698737000816 active site 698737000817 dimer interface [polypeptide binding]; other site 698737000818 catalytic residue [active] 698737000819 Sodium:solute symporter family; Region: SSF; cl00456 698737000820 putative transporter; Provisional; Region: PRK10484 698737000821 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 698737000822 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 698737000823 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 698737000824 Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983 698737000825 Helix-turn-helix domains; Region: HTH; cl00088 698737000826 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698737000827 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 698737000828 substrate binding site [chemical binding]; other site 698737000829 ATP binding site [chemical binding]; other site 698737000830 CAAX protease self-immunity; Region: Abi; cl00558 698737000831 CAAX protease self-immunity; Region: Abi; cl00558 698737000832 CAAX protease self-immunity; Region: Abi; cl00558 698737000833 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 698737000834 putative substrate binding pocket [chemical binding]; other site 698737000835 AC domain interface; other site 698737000836 catalytic triad [active] 698737000837 AB domain interface; other site 698737000838 interchain disulfide; other site 698737000839 Protein of unknown function (DUF979); Region: DUF979; cl01572 698737000840 Protein of unknown function (DUF969); Region: DUF969; cl01573 698737000841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737000842 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 698737000843 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 698737000844 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 698737000845 active site 698737000846 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 698737000847 Helix-turn-helix domains; Region: HTH; cl00088 698737000848 Helix-turn-helix domains; Region: HTH; cl00088 698737000849 PRD domain; Region: PRD; cl15445 698737000850 PRD domain; Region: PRD; cl15445 698737000851 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 698737000852 P-loop; other site 698737000853 active site 698737000854 phosphorylation site [posttranslational modification] 698737000855 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 698737000856 active site 698737000857 phosphorylation site [posttranslational modification] 698737000858 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 698737000859 active site 698737000860 phosphorylation site [posttranslational modification] 698737000861 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 698737000862 P-loop; other site 698737000863 active site 698737000864 phosphorylation site [posttranslational modification] 698737000865 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 698737000866 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 698737000867 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 698737000868 active site residue [active] 698737000869 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 698737000870 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 698737000871 Strictosidine synthase; Region: Str_synth; pfam03088 698737000872 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698737000873 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 698737000874 active site 698737000875 metal binding site [ion binding]; metal-binding site 698737000876 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 698737000877 hydrophobic ligand binding site; other site 698737000878 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 698737000879 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698737000880 substrate binding site [chemical binding]; other site 698737000881 dimer interface [polypeptide binding]; other site 698737000882 ATP binding site [chemical binding]; other site 698737000883 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 698737000884 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698737000885 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 698737000886 Walker A/P-loop; other site 698737000887 ATP binding site [chemical binding]; other site 698737000888 Q-loop/lid; other site 698737000889 ABC transporter signature motif; other site 698737000890 Walker B; other site 698737000891 D-loop; other site 698737000892 H-loop/switch region; other site 698737000893 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 698737000894 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698737000895 non-specific DNA binding site [nucleotide binding]; other site 698737000896 salt bridge; other site 698737000897 sequence-specific DNA binding site [nucleotide binding]; other site 698737000898 Tic20-like protein; Region: Tic20; pfam09685 698737000899 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 698737000900 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 698737000901 NADP binding site [chemical binding]; other site 698737000902 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 698737000903 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 698737000904 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 698737000905 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 698737000906 NlpC/P60 family; Region: NLPC_P60; cl11438 698737000907 Predicted membrane protein [Function unknown]; Region: COG1511 698737000908 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 698737000909 Predicted membrane protein [Function unknown]; Region: COG1511 698737000910 ABC-2 type transporter; Region: ABC2_membrane; cl11417 698737000911 YolD-like protein; Region: YolD; pfam08863 698737000912 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 698737000913 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 698737000914 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698737000915 DNA binding site [nucleotide binding] 698737000916 Int/Topo IB signature motif; other site 698737000917 active site 698737000918 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 698737000919 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698737000920 DNA binding site [nucleotide binding] 698737000921 Int/Topo IB signature motif; other site 698737000922 active site 698737000923 YolD-like protein; Region: YolD; pfam08863 698737000924 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698737000925 dimerization interface [polypeptide binding]; other site 698737000926 putative DNA binding site [nucleotide binding]; other site 698737000927 putative Zn2+ binding site [ion binding]; other site 698737000928 Predicted permease; Region: DUF318; pfam03773 698737000929 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698737000930 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698737000931 S-adenosylmethionine binding site [chemical binding]; other site 698737000932 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737000933 Amidinotransferase; Region: Amidinotransf; cl12043 698737000934 Predicted esterase [General function prediction only]; Region: COG0627 698737000935 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 698737000936 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 698737000937 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 698737000938 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 698737000939 putative active site [active] 698737000940 putative metal binding site [ion binding]; other site 698737000941 Protein of unknown function (DUF867); Region: DUF867; cl01713 698737000942 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 698737000943 Protein of unknown function (DUF2648); Region: DUF2648; pfam10855 698737000944 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 698737000945 Chain length determinant protein; Region: Wzz; cl15801 698737000946 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 698737000947 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737000948 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 698737000949 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 698737000950 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737000951 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 698737000952 NAD(P) binding site [chemical binding]; other site 698737000953 homodimer interface [polypeptide binding]; other site 698737000954 substrate binding site [chemical binding]; other site 698737000955 active site 698737000956 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 698737000957 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 698737000958 NAD(P) binding site [chemical binding]; other site 698737000959 homodimer interface [polypeptide binding]; other site 698737000960 substrate binding site [chemical binding]; other site 698737000961 active site 698737000962 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 698737000963 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737000964 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 698737000965 NAD(P) binding site [chemical binding]; other site 698737000966 active site 698737000967 Cupin domain; Region: Cupin_2; cl09118 698737000968 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 698737000969 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 698737000970 active site 698737000971 homodimer interface [polypeptide binding]; other site 698737000972 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 698737000973 trimer interface [polypeptide binding]; other site 698737000974 active site 698737000975 substrate binding site [chemical binding]; other site 698737000976 CoA binding site [chemical binding]; other site 698737000977 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 698737000978 MatE; Region: MatE; cl10513 698737000979 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698737000980 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 698737000981 Bacterial sugar transferase; Region: Bac_transf; cl00939 698737000982 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737000983 NAD(P) binding site [chemical binding]; other site 698737000984 active site 698737000985 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 698737000986 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 698737000987 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737000988 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 698737000989 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 698737000990 active site 698737000991 homodimer interface [polypeptide binding]; other site 698737000992 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 698737000993 dimer interface [polypeptide binding]; other site 698737000994 Alkaline phosphatase homologues; Region: alkPPc; smart00098 698737000995 active site 698737000996 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 698737000997 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698737000998 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698737000999 active site 698737001000 phosphorylation site [posttranslational modification] 698737001001 intermolecular recognition site; other site 698737001002 dimerization interface [polypeptide binding]; other site 698737001003 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698737001004 DNA binding site [nucleotide binding] 698737001005 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698737001006 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737001007 ATP binding site [chemical binding]; other site 698737001008 Mg2+ binding site [ion binding]; other site 698737001009 G-X-G motif; other site 698737001010 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698737001011 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 698737001012 Walker A/P-loop; other site 698737001013 ATP binding site [chemical binding]; other site 698737001014 Q-loop/lid; other site 698737001015 ABC transporter signature motif; other site 698737001016 Walker B; other site 698737001017 D-loop; other site 698737001018 H-loop/switch region; other site 698737001019 FtsX-like permease family; Region: FtsX; cl15850 698737001020 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 698737001021 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 698737001022 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 698737001023 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 698737001024 active site 698737001025 non-prolyl cis peptide bond; other site 698737001026 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 698737001027 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737001028 NAD(P) binding site [chemical binding]; other site 698737001029 active site 698737001030 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 698737001031 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 698737001032 Cadherin repeat-like domain; Region: CA_like; cl15786 698737001033 Cadherin repeat-like domain; Region: CA_like; cl15786 698737001034 Cadherin repeat-like domain; Region: CA_like; cl15786 698737001035 Cadherin repeat-like domain; Region: CA_like; cl15786 698737001036 Ca2+ binding site [ion binding]; other site 698737001037 Cadherin repeat-like domain; Region: CA_like; cl15786 698737001038 Ca2+ binding site [ion binding]; other site 698737001039 Cadherin repeat-like domain; Region: CA_like; cl15786 698737001040 Ca2+ binding site [ion binding]; other site 698737001041 Cadherin repeat-like domain; Region: CA_like; cl15786 698737001042 Cadherin repeat-like domain; Region: CA_like; cl15786 698737001043 Cadherin repeat-like domain; Region: CA_like; cl15786 698737001044 Cadherin repeat-like domain; Region: CA_like; cl15786 698737001045 Cadherin repeat-like domain; Region: CA_like; cl15786 698737001046 Cadherin repeat-like domain; Region: CA_like; cl15786 698737001047 Cadherin repeat-like domain; Region: CA_like; cl15786 698737001048 Cadherin repeat-like domain; Region: CA_like; cl15786 698737001049 Cadherin repeat-like domain; Region: CA_like; cl15786 698737001050 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 698737001051 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 698737001052 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 698737001053 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 698737001054 Gram positive anchor; Region: Gram_pos_anchor; cl15427 698737001055 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 698737001056 Active Sites [active] 698737001057 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 698737001058 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 698737001059 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 698737001060 FAD binding pocket [chemical binding]; other site 698737001061 FAD binding motif [chemical binding]; other site 698737001062 catalytic residues [active] 698737001063 NAD binding pocket [chemical binding]; other site 698737001064 phosphate binding motif [ion binding]; other site 698737001065 beta-alpha-beta structure motif; other site 698737001066 sulfite reductase subunit beta; Provisional; Region: PRK13504 698737001067 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 698737001068 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 698737001069 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 698737001070 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 698737001071 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 698737001072 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737001073 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 698737001074 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 698737001075 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 698737001076 ATP-sulfurylase; Region: ATPS; cd00517 698737001077 active site 698737001078 HXXH motif; other site 698737001079 flexible loop; other site 698737001080 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 698737001081 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 698737001082 ligand-binding site [chemical binding]; other site 698737001083 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 698737001084 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 698737001085 metal binding site [ion binding]; metal-binding site 698737001086 dimer interface [polypeptide binding]; other site 698737001087 NlpC/P60 family; Region: NLPC_P60; cl11438 698737001088 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 698737001089 Class III ribonucleotide reductase; Region: RNR_III; cd01675 698737001090 effector binding site; other site 698737001091 active site 698737001092 Zn binding site [ion binding]; other site 698737001093 glycine loop; other site 698737001094 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 698737001095 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 698737001096 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 698737001097 BCCT family transporter; Region: BCCT; cl00569 698737001098 Predicted transcriptional regulators [Transcription]; Region: COG1510 698737001099 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 698737001100 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698737001101 tetramerization interface [polypeptide binding]; other site 698737001102 NAD(P) binding site [chemical binding]; other site 698737001103 catalytic residues [active] 698737001104 choline dehydrogenase; Validated; Region: PRK02106 698737001105 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 698737001106 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698737001107 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 698737001108 metal binding site [ion binding]; metal-binding site 698737001109 dimer interface [polypeptide binding]; other site 698737001110 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 698737001111 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 698737001112 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 698737001113 AMP-binding enzyme; Region: AMP-binding; cl15778 698737001114 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 698737001115 pyruvate phosphate dikinase; Provisional; Region: PRK09279 698737001116 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 698737001117 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 698737001118 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 698737001119 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 698737001120 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737001121 Predicted dehydrogenase [General function prediction only]; Region: COG0579 698737001122 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 698737001123 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698737001124 DNA-binding site [nucleotide binding]; DNA binding site 698737001125 UTRA domain; Region: UTRA; cl01230 698737001126 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 698737001127 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 698737001128 active site turn [active] 698737001129 phosphorylation site [posttranslational modification] 698737001130 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 698737001131 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 698737001132 HPr interaction site; other site 698737001133 glycerol kinase (GK) interaction site [polypeptide binding]; other site 698737001134 active site 698737001135 phosphorylation site [posttranslational modification] 698737001136 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 698737001137 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698737001138 Helix-turn-helix domains; Region: HTH; cl00088 698737001139 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 698737001140 dimerization interface [polypeptide binding]; other site 698737001141 Helix-turn-helix domains; Region: HTH; cl00088 698737001142 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737001143 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737001144 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 698737001145 catalytic residue [active] 698737001146 Gram positive anchor; Region: Gram_pos_anchor; cl15427 698737001147 NMT1-like family; Region: NMT1_2; cl15260 698737001148 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 698737001149 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698737001150 inhibitor-cofactor binding pocket; inhibition site 698737001151 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737001152 catalytic residue [active] 698737001153 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 698737001154 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 698737001155 active site 698737001156 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 698737001157 active site 698737001158 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 698737001159 Spore germination protein; Region: Spore_permease; cl15802 698737001160 Spore germination protein; Region: Spore_permease; cl15802 698737001161 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698737001162 Helix-turn-helix domains; Region: HTH; cl00088 698737001163 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 698737001164 putative dimerization interface [polypeptide binding]; other site 698737001165 acetolactate synthase; Reviewed; Region: PRK08617 698737001166 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 698737001167 PYR/PP interface [polypeptide binding]; other site 698737001168 dimer interface [polypeptide binding]; other site 698737001169 TPP binding site [chemical binding]; other site 698737001170 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 698737001171 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 698737001172 TPP-binding site [chemical binding]; other site 698737001173 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 698737001174 glycolate transporter; Provisional; Region: PRK09695 698737001175 L-lactate permease; Region: Lactate_perm; cl00701 698737001176 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 698737001177 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 698737001178 quinone interaction residues [chemical binding]; other site 698737001179 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 698737001180 active site 698737001181 catalytic residues [active] 698737001182 FMN binding site [chemical binding]; other site 698737001183 substrate binding site [chemical binding]; other site 698737001184 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 698737001185 Phosphotransferase enzyme family; Region: APH; pfam01636 698737001186 active site 698737001187 substrate binding site [chemical binding]; other site 698737001188 ATP binding site [chemical binding]; other site 698737001189 Serine carboxypeptidase S28; Region: Peptidase_S28; cl15279 698737001190 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698737001191 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698737001192 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 698737001193 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737001194 NAD(P) binding site [chemical binding]; other site 698737001195 active site 698737001196 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 698737001197 Helix-turn-helix domains; Region: HTH; cl00088 698737001198 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 698737001199 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 698737001200 NmrA-like family; Region: NmrA; pfam05368 698737001201 NADP binding site [chemical binding]; other site 698737001202 active site 698737001203 regulatory binding site [polypeptide binding]; other site 698737001204 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 698737001205 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698737001206 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 698737001207 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698737001208 Helix-turn-helix domains; Region: HTH; cl00088 698737001209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737001210 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 698737001211 putative substrate translocation pore; other site 698737001212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737001213 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698737001214 Helix-turn-helix domains; Region: HTH; cl00088 698737001215 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 698737001216 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 698737001217 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 698737001218 Protein of unknown function, DUF488; Region: DUF488; cl01246 698737001219 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 698737001220 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 698737001221 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737001222 active site 698737001223 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 698737001224 OpgC protein; Region: OpgC_C; cl00792 698737001225 Acyltransferase family; Region: Acyl_transf_3; pfam01757 698737001226 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 698737001227 catalytic triad [active] 698737001228 catalytic triad [active] 698737001229 oxyanion hole [active] 698737001230 transaminase; Reviewed; Region: PRK08068 698737001231 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698737001232 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737001233 homodimer interface [polypeptide binding]; other site 698737001234 catalytic residue [active] 698737001235 D-lactate dehydrogenase; Validated; Region: PRK08605 698737001236 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737001237 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698737001238 metal-binding site [ion binding] 698737001239 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698737001240 metal-binding site [ion binding] 698737001241 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 698737001242 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698737001243 metal-binding site [ion binding] 698737001244 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698737001245 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 698737001246 maltose O-acetyltransferase; Provisional; Region: PRK10092 698737001247 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 698737001248 active site 698737001249 substrate binding site [chemical binding]; other site 698737001250 trimer interface [polypeptide binding]; other site 698737001251 CoA binding site [chemical binding]; other site 698737001252 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 698737001253 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 698737001254 putative ADP-binding pocket [chemical binding]; other site 698737001255 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737001256 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 698737001257 NAD(P) binding site [chemical binding]; other site 698737001258 active site 698737001259 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 698737001260 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 698737001261 Glutamate binding site [chemical binding]; other site 698737001262 homodimer interface [polypeptide binding]; other site 698737001263 NAD binding site [chemical binding]; other site 698737001264 catalytic residues [active] 698737001265 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 698737001266 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 698737001267 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 698737001268 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 698737001269 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 698737001270 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 698737001271 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 698737001272 DNA binding site [nucleotide binding] 698737001273 active site 698737001274 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 698737001275 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 698737001276 ABC-2 type transporter; Region: ABC2_membrane; cl11417 698737001277 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 698737001278 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263 698737001279 Walker A/P-loop; other site 698737001280 ATP binding site [chemical binding]; other site 698737001281 Q-loop/lid; other site 698737001282 ABC transporter signature motif; other site 698737001283 Walker B; other site 698737001284 D-loop; other site 698737001285 H-loop/switch region; other site 698737001286 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698737001287 Helix-turn-helix domains; Region: HTH; cl00088 698737001288 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...; Region: init_cond_enzymes; cd00827 698737001289 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 698737001290 dimer interface [polypeptide binding]; other site 698737001291 active site 698737001292 putative acyltransferase; Provisional; Region: PRK05790 698737001293 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 698737001294 dimer interface [polypeptide binding]; other site 698737001295 active site 698737001296 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 698737001297 homodimer interface [polypeptide binding]; other site 698737001298 NAD binding site [chemical binding]; other site 698737001299 catalytic residues [active] 698737001300 substrate binding pocket [chemical binding]; other site 698737001301 flexible flap; other site 698737001302 NlpC/P60 family; Region: NLPC_P60; cl11438 698737001303 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 698737001304 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698737001305 Helix-turn-helix domains; Region: HTH; cl00088 698737001306 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 698737001307 putative dimerization interface [polypeptide binding]; other site 698737001308 LrgA family; Region: LrgA; cl00608 698737001309 LrgB-like family; Region: LrgB; cl00596 698737001310 pyruvate oxidase; Provisional; Region: PRK08611 698737001311 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 698737001312 PYR/PP interface [polypeptide binding]; other site 698737001313 tetramer interface [polypeptide binding]; other site 698737001314 dimer interface [polypeptide binding]; other site 698737001315 TPP binding site [chemical binding]; other site 698737001316 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 698737001317 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 698737001318 TPP-binding site [chemical binding]; other site 698737001319 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 698737001320 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 698737001321 catalytic Zn binding site [ion binding]; other site 698737001322 structural Zn binding site [ion binding]; other site 698737001323 NAD(P) binding site [chemical binding]; other site 698737001324 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 698737001325 active site 698737001326 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698737001327 catalytic residues [active] 698737001328 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 698737001329 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 698737001330 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698737001331 NAD binding site [chemical binding]; other site 698737001332 dimer interface [polypeptide binding]; other site 698737001333 substrate binding site [chemical binding]; other site 698737001334 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 698737001335 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 698737001336 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 698737001337 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698737001338 Capsule biosynthesis CapC; Region: Caps_synth_CapC; cl14855 698737001339 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 698737001340 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 698737001341 putative active site [active] 698737001342 putative metal binding site [ion binding]; other site 698737001343 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 698737001344 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 698737001345 D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 698737001346 N- and C-terminal domain interface [polypeptide binding]; other site 698737001347 D-xylulose kinase; Region: XylB; TIGR01312 698737001348 active site 698737001349 catalytic site [active] 698737001350 metal binding site [ion binding]; metal-binding site 698737001351 xylulose binding site [chemical binding]; other site 698737001352 putative ATP binding site [chemical binding]; other site 698737001353 homodimer interface [polypeptide binding]; other site 698737001354 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 698737001355 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 698737001356 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 698737001357 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 698737001358 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 698737001359 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 698737001360 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 698737001361 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698737001362 Coenzyme A binding pocket [chemical binding]; other site 698737001363 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 698737001364 active site 698737001365 catalytic site [active] 698737001366 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 698737001367 G5 domain; Region: G5; pfam07501 698737001368 Plasmodium histidine-rich protein (HRPII/III); Region: Plasmodium_HRP; pfam05403 698737001369 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698737001370 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698737001371 active site 698737001372 motif I; other site 698737001373 motif II; other site 698737001374 Transposase IS200 like; Region: Y1_Tnp; cl00848 698737001375 D-lactate dehydrogenase; Provisional; Region: PRK12480 698737001376 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737001377 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 698737001378 dimer interface [polypeptide binding]; other site 698737001379 FMN binding site [chemical binding]; other site 698737001380 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 698737001381 Gram positive anchor; Region: Gram_pos_anchor; cl15427 698737001382 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 698737001383 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698737001384 NAD(P) binding site [chemical binding]; other site 698737001385 catalytic residues [active] 698737001386 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 698737001387 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 698737001388 putative metal binding site [ion binding]; other site 698737001389 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 698737001390 active site 698737001391 metal binding site [ion binding]; metal-binding site 698737001392 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 698737001393 Peptidase family M48; Region: Peptidase_M48; cl12018 698737001394 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698737001395 Helix-turn-helix domains; Region: HTH; cl00088 698737001396 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 698737001397 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698737001398 Zn binding site [ion binding]; other site 698737001399 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 698737001400 Zn binding site [ion binding]; other site 698737001401 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 698737001402 Zn binding site [ion binding]; other site 698737001403 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 698737001404 Zn binding site [ion binding]; other site 698737001405 Predicted esterase [General function prediction only]; Region: COG0400 698737001406 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 698737001407 nucleophilic elbow; other site 698737001408 catalytic triad; other site 698737001409 Uncharacterized membrane protein [Function unknown]; Region: COG3949 698737001410 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 698737001411 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 698737001412 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 698737001413 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 698737001414 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 698737001415 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 698737001416 ATP binding site [chemical binding]; other site 698737001417 substrate interface [chemical binding]; other site 698737001418 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 698737001419 ThiS interaction site; other site 698737001420 putative active site [active] 698737001421 tetramer interface [polypeptide binding]; other site 698737001422 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 698737001423 thiS-thiF/thiG interaction site; other site 698737001424 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737001425 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 698737001426 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 698737001427 thiamine phosphate binding site [chemical binding]; other site 698737001428 active site 698737001429 pyrophosphate binding site [ion binding]; other site 698737001430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737001431 D-galactonate transporter; Region: 2A0114; TIGR00893 698737001432 putative substrate translocation pore; other site 698737001433 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 698737001434 Predicted membrane protein [Function unknown]; Region: COG1289 698737001435 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 698737001436 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 698737001437 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 698737001438 synthetase active site [active] 698737001439 NTP binding site [chemical binding]; other site 698737001440 metal binding site [ion binding]; metal-binding site 698737001441 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698737001442 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 698737001443 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 698737001444 DNA binding residues [nucleotide binding] 698737001445 Transcriptional regulators [Transcription]; Region: GntR; COG1802 698737001446 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698737001447 DNA-binding site [nucleotide binding]; DNA binding site 698737001448 FCD domain; Region: FCD; cl11656 698737001449 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 698737001450 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 698737001451 N- and C-terminal domain interface [polypeptide binding]; other site 698737001452 putative active site [active] 698737001453 catalytic site [active] 698737001454 metal binding site [ion binding]; metal-binding site 698737001455 carbohydrate binding site [chemical binding]; other site 698737001456 ATP binding site [chemical binding]; other site 698737001457 GntP family permease; Region: GntP_permease; pfam02447 698737001458 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 698737001459 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 698737001460 active site 698737001461 tetramer interface; other site 698737001462 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 698737001463 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 698737001464 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 698737001465 active site 698737001466 substrate binding site [chemical binding]; other site 698737001467 metal binding site [ion binding]; metal-binding site 698737001468 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 698737001469 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 698737001470 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 698737001471 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737001472 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698737001473 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698737001474 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 698737001475 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 698737001476 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737001477 NAD(P) binding site [chemical binding]; other site 698737001478 active site 698737001479 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 698737001480 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 698737001481 metal binding site [ion binding]; metal-binding site 698737001482 polyphosphate kinase; Provisional; Region: PRK05443 698737001483 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 698737001484 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 698737001485 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 698737001486 putative domain interface [polypeptide binding]; other site 698737001487 putative active site [active] 698737001488 catalytic site [active] 698737001489 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 698737001490 putative domain interface [polypeptide binding]; other site 698737001491 putative active site [active] 698737001492 catalytic site [active] 698737001493 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 698737001494 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 698737001495 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 698737001496 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 698737001497 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 698737001498 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 698737001499 oligomer interface [polypeptide binding]; other site 698737001500 active site 698737001501 metal binding site [ion binding]; metal-binding site 698737001502 Protein of unknown function (DUF1307); Region: DUF1307; cl01981 698737001503 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 698737001504 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 698737001505 homodimer interface [polypeptide binding]; other site 698737001506 substrate-cofactor binding pocket; other site 698737001507 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737001508 catalytic residue [active] 698737001509 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 698737001510 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737001511 dimer interface [polypeptide binding]; other site 698737001512 conserved gate region; other site 698737001513 ABC-ATPase subunit interface; other site 698737001514 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 698737001515 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737001516 dimer interface [polypeptide binding]; other site 698737001517 conserved gate region; other site 698737001518 ABC-ATPase subunit interface; other site 698737001519 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 698737001520 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 698737001521 Walker A/P-loop; other site 698737001522 ATP binding site [chemical binding]; other site 698737001523 Q-loop/lid; other site 698737001524 ABC transporter signature motif; other site 698737001525 Walker B; other site 698737001526 D-loop; other site 698737001527 H-loop/switch region; other site 698737001528 NMT1-like family; Region: NMT1_2; cl15260 698737001529 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 698737001530 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 698737001531 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 698737001532 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 698737001533 active site 698737001534 metal binding site [ion binding]; metal-binding site 698737001535 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 698737001536 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 698737001537 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 698737001538 active site 698737001539 FMN binding site [chemical binding]; other site 698737001540 substrate binding site [chemical binding]; other site 698737001541 3Fe-4S cluster binding site [ion binding]; other site 698737001542 CAAX protease self-immunity; Region: Abi; cl00558 698737001543 CAAX protease self-immunity; Region: Abi; cl00558 698737001544 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 698737001545 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 698737001546 Walker A/P-loop; other site 698737001547 ATP binding site [chemical binding]; other site 698737001548 Q-loop/lid; other site 698737001549 ABC transporter signature motif; other site 698737001550 Walker B; other site 698737001551 D-loop; other site 698737001552 H-loop/switch region; other site 698737001553 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 698737001554 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698737001555 dimer interface [polypeptide binding]; other site 698737001556 phosphorylation site [posttranslational modification] 698737001557 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737001558 ATP binding site [chemical binding]; other site 698737001559 Mg2+ binding site [ion binding]; other site 698737001560 G-X-G motif; other site 698737001561 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698737001562 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698737001563 active site 698737001564 phosphorylation site [posttranslational modification] 698737001565 intermolecular recognition site; other site 698737001566 dimerization interface [polypeptide binding]; other site 698737001567 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698737001568 DNA binding site [nucleotide binding] 698737001569 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 698737001570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737001571 putative substrate translocation pore; other site 698737001572 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 698737001573 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 698737001574 substrate binding pocket [chemical binding]; other site 698737001575 catalytic triad [active] 698737001576 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 698737001577 Protein of unknown function (DUF419); Region: DUF419; cl15265 698737001578 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 698737001579 potential frameshift: common BLAST hit: gi|224477817|ref|YP_002635423.1| alcohol dehydrogenase, zinc-containing 698737001580 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737001581 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 698737001582 putative NAD(P) binding site [chemical binding]; other site 698737001583 catalytic Zn binding site [ion binding]; other site 698737001584 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 698737001585 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 698737001586 Walker A/P-loop; other site 698737001587 ATP binding site [chemical binding]; other site 698737001588 Q-loop/lid; other site 698737001589 ABC transporter signature motif; other site 698737001590 Walker B; other site 698737001591 D-loop; other site 698737001592 H-loop/switch region; other site 698737001593 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 698737001594 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737001595 dimer interface [polypeptide binding]; other site 698737001596 conserved gate region; other site 698737001597 putative PBP binding loops; other site 698737001598 ABC-ATPase subunit interface; other site 698737001599 NMT1-like family; Region: NMT1_2; cl15260 698737001600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698737001601 LXG domain of WXG superfamily; Region: LXG; pfam04740 698737001602 Protein of unknown function (DUF443); Region: DUF443; cl04467 698737001603 Protein of unknown function (DUF443); Region: DUF443; cl04467 698737001604 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 698737001605 Protein of unknown function (DUF443); Region: DUF443; cl04467 698737001606 LrgB-like family; Region: LrgB; cl00596 698737001607 LrgA family; Region: LrgA; cl00608 698737001608 two-component response regulator; Provisional; Region: PRK14084 698737001609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698737001610 active site 698737001611 phosphorylation site [posttranslational modification] 698737001612 intermolecular recognition site; other site 698737001613 dimerization interface [polypeptide binding]; other site 698737001614 LytTr DNA-binding domain; Region: LytTR; cl04498 698737001615 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 698737001616 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 698737001617 GAF domain; Region: GAF; cl15785 698737001618 Histidine kinase; Region: His_kinase; pfam06580 698737001619 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737001620 ATP binding site [chemical binding]; other site 698737001621 Mg2+ binding site [ion binding]; other site 698737001622 G-X-G motif; other site 698737001623 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 698737001624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737001625 putative substrate translocation pore; other site 698737001626 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 698737001627 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737001628 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 698737001629 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 698737001630 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737001631 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 698737001632 NAD(P) binding site [chemical binding]; other site 698737001633 active site 698737001634 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 698737001635 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 698737001636 DHHC palmitoyltransferase; Region: zf-DHHC; pfam01529 698737001637 Amino acid permease; Region: AA_permease_2; pfam13520 698737001638 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 698737001639 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 698737001640 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 698737001641 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 698737001642 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 698737001643 active site 698737001644 metal binding site [ion binding]; metal-binding site 698737001645 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 698737001646 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 698737001647 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 698737001648 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 698737001649 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737001650 putative substrate translocation pore; other site 698737001651 Glycerate kinase family; Region: Gly_kinase; cl00841 698737001652 GtrA-like protein; Region: GtrA; cl00971 698737001653 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 698737001654 Cation efflux family; Region: Cation_efflux; cl00316 698737001655 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698737001656 catalytic core [active] 698737001657 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698737001658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737001659 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698737001660 putative substrate translocation pore; other site 698737001661 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698737001662 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698737001663 substrate binding pocket [chemical binding]; other site 698737001664 membrane-bound complex binding site; other site 698737001665 hinge residues; other site 698737001666 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698737001667 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737001668 dimer interface [polypeptide binding]; other site 698737001669 conserved gate region; other site 698737001670 putative PBP binding loops; other site 698737001671 ABC-ATPase subunit interface; other site 698737001672 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698737001673 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 698737001674 Walker A/P-loop; other site 698737001675 ATP binding site [chemical binding]; other site 698737001676 Q-loop/lid; other site 698737001677 ABC transporter signature motif; other site 698737001678 Walker B; other site 698737001679 D-loop; other site 698737001680 H-loop/switch region; other site 698737001681 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 698737001682 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 698737001683 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 698737001684 putative hydrophobic ligand binding site [chemical binding]; other site 698737001685 ABC-2 type transporter; Region: ABC2_membrane; cl11417 698737001686 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 698737001687 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737001688 Walker A/P-loop; other site 698737001689 ATP binding site [chemical binding]; other site 698737001690 Q-loop/lid; other site 698737001691 ABC transporter signature motif; other site 698737001692 Walker B; other site 698737001693 D-loop; other site 698737001694 H-loop/switch region; other site 698737001695 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 698737001696 putative active site [active] 698737001697 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 698737001698 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 698737001699 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 698737001700 putative active site [active] 698737001701 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 698737001702 active site 698737001703 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 698737001704 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698737001705 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 698737001706 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 698737001707 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 698737001708 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 698737001709 [2Fe-2S] cluster binding site [ion binding]; other site 698737001710 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 698737001711 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 698737001712 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 698737001713 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 698737001714 [4Fe-4S] binding site [ion binding]; other site 698737001715 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698737001716 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698737001717 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698737001718 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 698737001719 molybdopterin cofactor binding site; other site 698737001720 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 698737001721 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 698737001722 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 698737001723 potential frameshift: common BLAST hit: gi|269204025|ref|YP_003283294.1| NreA 698737001724 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 698737001725 Histidine kinase; Region: HisKA_3; pfam07730 698737001726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737001727 ATP binding site [chemical binding]; other site 698737001728 Mg2+ binding site [ion binding]; other site 698737001729 G-X-G motif; other site 698737001730 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698737001731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698737001732 active site 698737001733 phosphorylation site [posttranslational modification] 698737001734 intermolecular recognition site; other site 698737001735 dimerization interface [polypeptide binding]; other site 698737001736 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698737001737 DNA binding residues [nucleotide binding] 698737001738 dimerization interface [polypeptide binding]; other site 698737001739 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 698737001740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737001741 putative substrate translocation pore; other site 698737001742 Helix-turn-helix domains; Region: HTH; cl00088 698737001743 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 698737001744 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 698737001745 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 698737001746 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 698737001747 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698737001748 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698737001749 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 698737001750 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 698737001751 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 698737001752 active site turn [active] 698737001753 phosphorylation site [posttranslational modification] 698737001754 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 698737001755 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 698737001756 Helix-turn-helix domains; Region: HTH; cl00088 698737001757 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 698737001758 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 698737001759 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 698737001760 ABC-2 type transporter; Region: ABC2_membrane; cl11417 698737001761 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698737001762 Helix-turn-helix domains; Region: HTH; cl00088 698737001763 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 698737001764 MatE; Region: MatE; cl10513 698737001765 MatE; Region: MatE; cl10513 698737001766 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 698737001767 potential frameshift: common BLAST hit: gi|87162114|ref|YP_492795.1| ABC transporter ATP-binding protein 698737001768 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737001769 ABC transporter signature motif; other site 698737001770 Walker B; other site 698737001771 D-loop; other site 698737001772 H-loop/switch region; other site 698737001773 ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The...; Region: ABC_ATPase; cd00267 698737001774 Walker A/P-loop; other site 698737001775 ATP binding site [chemical binding]; other site 698737001776 Q-loop/lid; other site 698737001777 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 698737001778 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 698737001779 Walker A/P-loop; other site 698737001780 ATP binding site [chemical binding]; other site 698737001781 Q-loop/lid; other site 698737001782 ABC transporter signature motif; other site 698737001783 Walker B; other site 698737001784 D-loop; other site 698737001785 H-loop/switch region; other site 698737001786 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698737001787 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698737001788 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698737001789 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698737001790 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 698737001791 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698737001792 UreD urease accessory protein; Region: UreD; cl00530 698737001793 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737001794 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 698737001795 UreF; Region: UreF; pfam01730 698737001796 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 698737001797 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 698737001798 dimer interface [polypeptide binding]; other site 698737001799 catalytic residues [active] 698737001800 urease subunit alpha; Reviewed; Region: ureC; PRK13207 698737001801 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 698737001802 subunit interactions [polypeptide binding]; other site 698737001803 active site 698737001804 flap region; other site 698737001805 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 698737001806 gamma-beta subunit interface [polypeptide binding]; other site 698737001807 alpha-beta subunit interface [polypeptide binding]; other site 698737001808 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 698737001809 alpha-gamma subunit interface [polypeptide binding]; other site 698737001810 beta-gamma subunit interface [polypeptide binding]; other site 698737001811 Urea transporter; Region: UT; cl01829 698737001812 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698737001813 Helix-turn-helix domains; Region: HTH; cl00088 698737001814 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737001815 ThiC-associated domain; Region: ThiC-associated; pfam13667 698737001816 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 698737001817 ThiC family; Region: ThiC; cl08031 698737001818 Predicted permeases [General function prediction only]; Region: RarD; COG2962 698737001819 Protein of unknown function (DUF443); Region: DUF443; cl04467 698737001820 Integral membrane protein DUF95; Region: DUF95; cl00572 698737001821 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698737001822 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 698737001823 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 698737001824 ABC transporter; Region: ABC_tran_2; pfam12848 698737001825 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 698737001826 Protein of unknown function (DUF443); Region: DUF443; cl04467 698737001827 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 698737001828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737001829 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698737001830 Helix-turn-helix domains; Region: HTH; cl00088 698737001831 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 698737001832 dimerization interface [polypeptide binding]; other site 698737001833 Predicted acetyltransferase [General function prediction only]; Region: COG3153 698737001834 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698737001835 Coenzyme A binding pocket [chemical binding]; other site 698737001836 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698737001837 non-specific DNA binding site [nucleotide binding]; other site 698737001838 salt bridge; other site 698737001839 sequence-specific DNA binding site [nucleotide binding]; other site 698737001840 CAAX protease self-immunity; Region: Abi; cl00558 698737001841 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698737001842 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 698737001843 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698737001844 HsdM N-terminal domain; Region: HsdM_N; pfam12161 698737001845 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 698737001846 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698737001847 S-adenosylmethionine binding site [chemical binding]; other site 698737001848 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737001849 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 698737001850 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 698737001851 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698737001852 ATP binding site [chemical binding]; other site 698737001853 putative Mg++ binding site [ion binding]; other site 698737001854 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698737001855 non-specific DNA binding site [nucleotide binding]; other site 698737001856 salt bridge; other site 698737001857 sequence-specific DNA binding site [nucleotide binding]; other site 698737001858 CAAX protease self-immunity; Region: Abi; cl00558 698737001859 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698737001860 sequence-specific DNA binding site [nucleotide binding]; other site 698737001861 salt bridge; other site 698737001862 TM2 domain; Region: TM2; cl00984 698737001863 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 698737001864 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737001865 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737001866 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698737001867 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 698737001868 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737001869 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 698737001870 NAD(P) binding site [chemical binding]; other site 698737001871 Imelysin; Region: Peptidase_M75; cl09159 698737001872 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 698737001873 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 698737001874 Iron permease FTR1 family; Region: FTR1; cl00475 698737001875 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 698737001876 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 698737001877 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 698737001878 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 698737001879 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 698737001880 glycolate transporter; Provisional; Region: PRK09695 698737001881 L-lactate permease; Region: Lactate_perm; cl00701 698737001882 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698737001883 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 698737001884 putative ADP-binding pocket [chemical binding]; other site 698737001885 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737001886 Predicted dehydrogenase [General function prediction only]; Region: COG0579 698737001887 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 698737001888 LytTr DNA-binding domain; Region: LytTR; cl04498 698737001889 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698737001890 dimerization interface [polypeptide binding]; other site 698737001891 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698737001892 dimer interface [polypeptide binding]; other site 698737001893 phosphorylation site [posttranslational modification] 698737001894 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737001895 ATP binding site [chemical binding]; other site 698737001896 Mg2+ binding site [ion binding]; other site 698737001897 G-X-G motif; other site 698737001898 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698737001899 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698737001900 active site 698737001901 phosphorylation site [posttranslational modification] 698737001902 intermolecular recognition site; other site 698737001903 dimerization interface [polypeptide binding]; other site 698737001904 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698737001905 DNA binding site [nucleotide binding] 698737001906 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698737001907 FtsX-like permease family; Region: FtsX; cl15850 698737001908 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 698737001909 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698737001910 Walker A/P-loop; other site 698737001911 ATP binding site [chemical binding]; other site 698737001912 Q-loop/lid; other site 698737001913 ABC transporter signature motif; other site 698737001914 Walker B; other site 698737001915 D-loop; other site 698737001916 H-loop/switch region; other site 698737001917 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 698737001918 putative active site [active] 698737001919 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698737001920 Helix-turn-helix domains; Region: HTH; cl00088 698737001921 Predicted membrane protein [Function unknown]; Region: COG4640 698737001922 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 698737001923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737001924 putative substrate translocation pore; other site 698737001925 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698737001926 Helix-turn-helix domains; Region: HTH; cl00088 698737001927 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 698737001928 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698737001929 E3 interaction surface; other site 698737001930 lipoyl attachment site [posttranslational modification]; other site 698737001931 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 698737001932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737001933 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 698737001934 putative substrate translocation pore; other site 698737001935 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 698737001936 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 698737001937 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 698737001938 active site 698737001939 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 698737001940 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 698737001941 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 698737001942 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 698737001943 homotetramer interface [polypeptide binding]; other site 698737001944 FMN binding site [chemical binding]; other site 698737001945 homodimer contacts [polypeptide binding]; other site 698737001946 putative active site [active] 698737001947 putative substrate binding site [chemical binding]; other site 698737001948 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 698737001949 active site 698737001950 DNA binding site [nucleotide binding] 698737001951 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698737001952 non-specific DNA binding site [nucleotide binding]; other site 698737001953 salt bridge; other site 698737001954 sequence-specific DNA binding site [nucleotide binding]; other site 698737001955 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 698737001956 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 698737001957 active site 698737001958 catalytic residues [active] 698737001959 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 698737001960 MOSC domain; Region: MOSC; pfam03473 698737001961 3-alpha domain; Region: 3-alpha; pfam03475 698737001962 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 698737001963 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698737001964 active site 698737001965 dimer interface [polypeptide binding]; other site 698737001966 CAAX protease self-immunity; Region: Abi; cl00558 698737001967 Homeobox prospero-like protein (PROX1); Region: Prox1; pfam05044 698737001968 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 698737001969 amidohydrolase; Region: amidohydrolases; TIGR01891 698737001970 metal binding site [ion binding]; metal-binding site 698737001971 oxidoreductase; Provisional; Region: PRK07985 698737001972 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737001973 NAD(P) binding site [chemical binding]; other site 698737001974 active site 698737001975 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 698737001976 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 698737001977 putative hydrophobic ligand binding site [chemical binding]; other site 698737001978 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 698737001979 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 698737001980 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 698737001981 putative active site [active] 698737001982 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 698737001983 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 698737001984 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 698737001985 active site turn [active] 698737001986 phosphorylation site [posttranslational modification] 698737001987 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 698737001988 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698737001989 active site 698737001990 motif I; other site 698737001991 motif II; other site 698737001992 putative transport protein YifK; Provisional; Region: PRK10746 698737001993 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 698737001994 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 698737001995 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 698737001996 putative active site [active] 698737001997 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 698737001998 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 698737001999 active site turn [active] 698737002000 phosphorylation site [posttranslational modification] 698737002001 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 698737002002 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 698737002003 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 698737002004 putative active site [active] 698737002005 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 698737002006 Predicted transcriptional regulator [Transcription]; Region: COG2378 698737002007 Helix-turn-helix domains; Region: HTH; cl00088 698737002008 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 698737002009 active site 698737002010 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 698737002011 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 698737002012 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 698737002013 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 698737002014 4Fe-4S binding domain; Region: Fer4; cl02805 698737002015 4Fe-4S binding domain; Region: Fer4; cl02805 698737002016 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 698737002017 [4Fe-4S] binding site [ion binding]; other site 698737002018 molybdopterin cofactor binding site; other site 698737002019 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 698737002020 molybdopterin cofactor binding site; other site 698737002021 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 698737002022 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 698737002023 glyoxylate reductase; Reviewed; Region: PRK13243 698737002024 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737002025 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 698737002026 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 698737002027 NlpC/P60 family; Region: NLPC_P60; cl11438 698737002028 Tic20-like protein; Region: Tic20; pfam09685 698737002029 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737002030 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 698737002031 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 698737002032 NlpC/P60 family; Region: NLPC_P60; cl11438 698737002033 potential frameshift: common BLAST hit: gi|27468789|ref|NP_765426.1| transcription regulator 698737002034 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 698737002035 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698737002036 Helix-turn-helix domains; Region: HTH; cl00088 698737002037 Helix-turn-helix domains; Region: HTH; cl00088 698737002038 Helix-turn-helix domains; Region: HTH; cl00088 698737002039 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698737002040 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 698737002041 Walker A motif; other site 698737002042 ATP binding site [chemical binding]; other site 698737002043 Walker B motif; other site 698737002044 arginine finger; other site 698737002045 UvrB/uvrC motif; Region: UVR; pfam02151 698737002046 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698737002047 Walker A motif; other site 698737002048 ATP binding site [chemical binding]; other site 698737002049 Walker B motif; other site 698737002050 arginine finger; other site 698737002051 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 698737002052 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 698737002053 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 698737002054 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 698737002055 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 698737002056 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698737002057 intersubunit interface [polypeptide binding]; other site 698737002058 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 698737002059 active site 698737002060 dimerization interface [polypeptide binding]; other site 698737002061 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 698737002062 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 698737002063 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 698737002064 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 698737002065 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698737002066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737002067 dimer interface [polypeptide binding]; other site 698737002068 conserved gate region; other site 698737002069 putative PBP binding loops; other site 698737002070 ABC-ATPase subunit interface; other site 698737002071 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737002072 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698737002073 Walker A/P-loop; other site 698737002074 ATP binding site [chemical binding]; other site 698737002075 Q-loop/lid; other site 698737002076 ABC transporter signature motif; other site 698737002077 Walker B; other site 698737002078 D-loop; other site 698737002079 H-loop/switch region; other site 698737002080 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 698737002081 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 698737002082 ATP binding site [chemical binding]; other site 698737002083 substrate interface [chemical binding]; other site 698737002084 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698737002085 MPT binding site; other site 698737002086 trimer interface [polypeptide binding]; other site 698737002087 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 698737002088 trimer interface [polypeptide binding]; other site 698737002089 dimer interface [polypeptide binding]; other site 698737002090 putative active site [active] 698737002091 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 698737002092 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 698737002093 dimer interface [polypeptide binding]; other site 698737002094 putative functional site; other site 698737002095 putative MPT binding site; other site 698737002096 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737002097 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 698737002098 MoaE homodimer interface [polypeptide binding]; other site 698737002099 MoaD interaction [polypeptide binding]; other site 698737002100 active site residues [active] 698737002101 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 698737002102 MoaE interaction surface [polypeptide binding]; other site 698737002103 MoeB interaction surface [polypeptide binding]; other site 698737002104 thiocarboxylated glycine; other site 698737002105 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 698737002106 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 698737002107 GTP binding site; other site 698737002108 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 698737002109 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698737002110 FeS/SAM binding site; other site 698737002111 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 698737002112 Helix-turn-helix domains; Region: HTH; cl00088 698737002113 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698737002114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737002115 putative substrate translocation pore; other site 698737002116 Helix-turn-helix domains; Region: HTH; cl00088 698737002117 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698737002118 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 698737002119 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 698737002120 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 698737002121 Protein export membrane protein; Region: SecD_SecF; cl14618 698737002122 Membrane transport protein; Region: Mem_trans; cl09117 698737002123 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698737002124 Coenzyme A binding pocket [chemical binding]; other site 698737002125 DNA topoisomerase III; Provisional; Region: PRK07726 698737002126 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 698737002127 active site 698737002128 putative interdomain interaction site [polypeptide binding]; other site 698737002129 putative metal-binding site [ion binding]; other site 698737002130 putative nucleotide binding site [chemical binding]; other site 698737002131 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 698737002132 domain I; other site 698737002133 DNA binding groove [nucleotide binding] 698737002134 phosphate binding site [ion binding]; other site 698737002135 domain II; other site 698737002136 domain III; other site 698737002137 nucleotide binding site [chemical binding]; other site 698737002138 catalytic site [active] 698737002139 domain IV; other site 698737002140 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 698737002141 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 698737002142 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 698737002143 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 698737002144 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 698737002145 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 698737002146 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 698737002147 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 698737002148 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 698737002149 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 698737002150 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 698737002151 putative translocon binding site; other site 698737002152 protein-rRNA interface [nucleotide binding]; other site 698737002153 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 698737002154 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 698737002155 G-X-X-G motif; other site 698737002156 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 698737002157 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 698737002158 23S rRNA interface [nucleotide binding]; other site 698737002159 5S rRNA interface [nucleotide binding]; other site 698737002160 putative antibiotic binding site [chemical binding]; other site 698737002161 L25 interface [polypeptide binding]; other site 698737002162 L27 interface [polypeptide binding]; other site 698737002163 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 698737002164 23S rRNA interface [nucleotide binding]; other site 698737002165 putative translocon interaction site; other site 698737002166 signal recognition particle (SRP54) interaction site; other site 698737002167 L23 interface [polypeptide binding]; other site 698737002168 trigger factor interaction site; other site 698737002169 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 698737002170 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 698737002171 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 698737002172 KOW motif; Region: KOW; cl00354 698737002173 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 698737002174 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 698737002175 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 698737002176 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 698737002177 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 698737002178 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 698737002179 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 698737002180 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 698737002181 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 698737002182 5S rRNA interface [nucleotide binding]; other site 698737002183 L27 interface [polypeptide binding]; other site 698737002184 23S rRNA interface [nucleotide binding]; other site 698737002185 L5 interface [polypeptide binding]; other site 698737002186 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 698737002187 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 698737002188 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 698737002189 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 698737002190 23S rRNA binding site [nucleotide binding]; other site 698737002191 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 698737002192 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 698737002193 SecY translocase; Region: SecY; pfam00344 698737002194 adenylate kinase; Reviewed; Region: adk; PRK00279 698737002195 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 698737002196 AMP-binding site [chemical binding]; other site 698737002197 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 698737002198 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 698737002199 rRNA binding site [nucleotide binding]; other site 698737002200 predicted 30S ribosome binding site; other site 698737002201 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 698737002202 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 698737002203 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 698737002204 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 698737002205 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 698737002206 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 698737002207 alphaNTD homodimer interface [polypeptide binding]; other site 698737002208 alphaNTD - beta interaction site [polypeptide binding]; other site 698737002209 alphaNTD - beta' interaction site [polypeptide binding]; other site 698737002210 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 698737002211 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 698737002212 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648 698737002213 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 698737002214 Walker A/P-loop; other site 698737002215 ATP binding site [chemical binding]; other site 698737002216 Q-loop/lid; other site 698737002217 ABC transporter signature motif; other site 698737002218 Walker B; other site 698737002219 D-loop; other site 698737002220 H-loop/switch region; other site 698737002221 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646 698737002222 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 698737002223 Walker A/P-loop; other site 698737002224 ATP binding site [chemical binding]; other site 698737002225 Q-loop/lid; other site 698737002226 ABC transporter signature motif; other site 698737002227 Walker B; other site 698737002228 D-loop; other site 698737002229 H-loop/switch region; other site 698737002230 Cobalt transport protein; Region: CbiQ; cl00463 698737002231 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 698737002232 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 698737002233 dimerization interface 3.5A [polypeptide binding]; other site 698737002234 active site 698737002235 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 698737002236 23S rRNA interface [nucleotide binding]; other site 698737002237 L3 interface [polypeptide binding]; other site 698737002238 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 698737002239 Helix-turn-helix domains; Region: HTH; cl00088 698737002240 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 698737002241 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698737002242 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737002243 Walker A/P-loop; other site 698737002244 ATP binding site [chemical binding]; other site 698737002245 Q-loop/lid; other site 698737002246 ABC transporter signature motif; other site 698737002247 Walker B; other site 698737002248 D-loop; other site 698737002249 H-loop/switch region; other site 698737002250 ABC-2 type transporter; Region: ABC2_membrane; cl11417 698737002251 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 698737002252 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 698737002253 Walker A/P-loop; other site 698737002254 ATP binding site [chemical binding]; other site 698737002255 Q-loop/lid; other site 698737002256 ABC transporter signature motif; other site 698737002257 Walker B; other site 698737002258 D-loop; other site 698737002259 H-loop/switch region; other site 698737002260 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698737002261 Helix-turn-helix domains; Region: HTH; cl00088 698737002262 peptide synthase; Provisional; Region: PRK12316 698737002263 AMP-binding enzyme; Region: AMP-binding; cl15778 698737002264 Phosphopantetheine attachment site; Region: PP-binding; cl09936 698737002265 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 698737002266 AMP-binding enzyme; Region: AMP-binding; cl15778 698737002267 Phosphopantetheine attachment site; Region: PP-binding; cl09936 698737002268 Condensation domain; Region: Condensation; pfam00668 698737002269 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 698737002270 AMP-binding enzyme; Region: AMP-binding; cl15778 698737002271 peptide synthase; Validated; Region: PRK05691 698737002272 Phosphopantetheine attachment site; Region: PP-binding; cl09936 698737002273 peptide synthase; Provisional; Region: PRK12316 698737002274 AMP-binding enzyme; Region: AMP-binding; cl15778 698737002275 Phosphopantetheine attachment site; Region: PP-binding; cl09936 698737002276 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 698737002277 peptide synthase; Provisional; Region: PRK12316 698737002278 Phosphopantetheine attachment site; Region: PP-binding; cl09936 698737002279 Condensation domain; Region: Condensation; pfam00668 698737002280 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 698737002281 Phosphopantetheine attachment site; Region: PP-binding; cl09936 698737002282 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737002283 NAD(P) binding site [chemical binding]; other site 698737002284 active site 698737002285 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 698737002286 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 698737002287 AMP-binding enzyme; Region: AMP-binding; cl15778 698737002288 Phosphopantetheine attachment site; Region: PP-binding; cl09936 698737002289 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 698737002290 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 698737002291 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 698737002292 NAD-dependent deacetylase; Provisional; Region: PRK00481 698737002293 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 698737002294 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698737002295 Helix-turn-helix domains; Region: HTH; cl00088 698737002296 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 698737002297 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 698737002298 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 698737002299 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 698737002300 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 698737002301 putative substrate binding site [chemical binding]; other site 698737002302 putative ATP binding site [chemical binding]; other site 698737002303 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 698737002304 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 698737002305 methionine cluster; other site 698737002306 active site 698737002307 phosphorylation site [posttranslational modification] 698737002308 metal binding site [ion binding]; metal-binding site 698737002309 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 698737002310 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 698737002311 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 698737002312 P-loop; other site 698737002313 active site 698737002314 phosphorylation site [posttranslational modification] 698737002315 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 698737002316 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 698737002317 Prostaglandin dehydrogenases; Region: PGDH; cd05288 698737002318 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 698737002319 NAD(P) binding site [chemical binding]; other site 698737002320 substrate binding site [chemical binding]; other site 698737002321 dimer interface [polypeptide binding]; other site 698737002322 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 698737002323 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 698737002324 putative NAD(P) binding site [chemical binding]; other site 698737002325 dimer interface [polypeptide binding]; other site 698737002326 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 698737002327 Asp23 family; Region: Asp23; cl00574 698737002328 IucA / IucC family; Region: IucA_IucC; pfam04183 698737002329 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 698737002330 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 698737002331 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 698737002332 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698737002333 catalytic residue [active] 698737002334 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 698737002335 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698737002336 siderophore binding site; other site 698737002337 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698737002338 ABC-ATPase subunit interface; other site 698737002339 dimer interface [polypeptide binding]; other site 698737002340 putative PBP binding regions; other site 698737002341 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698737002342 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698737002343 ABC-ATPase subunit interface; other site 698737002344 dimer interface [polypeptide binding]; other site 698737002345 putative PBP binding regions; other site 698737002346 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 698737002347 Nucleoside recognition; Region: Gate; cl00486 698737002348 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 698737002349 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 698737002350 substrate binding site; other site 698737002351 dimerization interface; other site 698737002352 Haemolysin-III related; Region: HlyIII; cl03831 698737002353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737002354 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698737002355 putative substrate translocation pore; other site 698737002356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737002357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737002358 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 698737002359 putative substrate translocation pore; other site 698737002360 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 698737002361 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 698737002362 Walker A motif; other site 698737002363 TIGR00159 family protein; Region: TIGR00159 698737002364 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 698737002365 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 698737002366 YbbR-like protein; Region: YbbR; pfam07949 698737002367 YbbR-like protein; Region: YbbR; pfam07949 698737002368 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 698737002369 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 698737002370 active site 698737002371 substrate binding site [chemical binding]; other site 698737002372 metal binding site [ion binding]; metal-binding site 698737002373 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 698737002374 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 698737002375 glutaminase active site [active] 698737002376 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 698737002377 dimer interface [polypeptide binding]; other site 698737002378 active site 698737002379 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 698737002380 dimer interface [polypeptide binding]; other site 698737002381 active site 698737002382 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698737002383 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698737002384 active site 698737002385 motif I; other site 698737002386 motif II; other site 698737002387 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698737002388 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 698737002389 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698737002390 active site 698737002391 metal binding site [ion binding]; metal-binding site 698737002392 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 698737002393 Cation efflux family; Region: Cation_efflux; cl00316 698737002394 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698737002395 dimerization interface [polypeptide binding]; other site 698737002396 putative DNA binding site [nucleotide binding]; other site 698737002397 putative Zn2+ binding site [ion binding]; other site 698737002398 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 698737002399 NADH(P)-binding; Region: NAD_binding_10; pfam13460 698737002400 NAD(P) binding site [chemical binding]; other site 698737002401 putative active site [active] 698737002402 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 698737002403 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 698737002404 EVE domain; Region: EVE; cl00728 698737002405 MoxR-like ATPases [General function prediction only]; Region: COG0714 698737002406 Protein of unknown function, DUF393; Region: DUF393; cl01136 698737002407 Ferritin-like domain; Region: Ferritin; pfam00210 698737002408 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 698737002409 dimerization interface [polypeptide binding]; other site 698737002410 DPS ferroxidase diiron center [ion binding]; other site 698737002411 ion pore; other site 698737002412 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 698737002413 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 698737002414 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 698737002415 intersubunit interface [polypeptide binding]; other site 698737002416 active site 698737002417 catalytic residue [active] 698737002418 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 698737002419 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 698737002420 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 698737002421 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 698737002422 Sulfatase; Region: Sulfatase; cl10460 698737002423 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 698737002424 Predicted membrane protein [Function unknown]; Region: COG4270 698737002425 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 698737002426 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 698737002427 G1 box; other site 698737002428 GTP/Mg2+ binding site [chemical binding]; other site 698737002429 Switch I region; other site 698737002430 G2 box; other site 698737002431 G3 box; other site 698737002432 Switch II region; other site 698737002433 G4 box; other site 698737002434 G5 box; other site 698737002435 Nucleoside recognition; Region: Gate; cl00486 698737002436 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 698737002437 Nucleoside recognition; Region: Gate; cl00486 698737002438 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 698737002439 Helix-turn-helix domains; Region: HTH; cl00088 698737002440 Integrase core domain; Region: rve; cl01316 698737002441 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 698737002442 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 698737002443 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 698737002444 catalytic residues [active] 698737002445 catalytic nucleophile [active] 698737002446 Presynaptic Site I dimer interface [polypeptide binding]; other site 698737002447 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 698737002448 Synaptic Flat tetramer interface [polypeptide binding]; other site 698737002449 Synaptic Site I dimer interface [polypeptide binding]; other site 698737002450 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 698737002451 DNA-binding interface [nucleotide binding]; DNA binding site 698737002452 Helix-turn-helix domains; Region: HTH; cl00088 698737002453 BlaR1 peptidase M56; Region: Peptidase_M56; cl15829 698737002454 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 698737002455 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 698737002456 beta-lactamase TEM; Provisional; Region: PRK15442 698737002457 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 698737002458 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 698737002459 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698737002460 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 698737002461 metal binding site [ion binding]; metal-binding site 698737002462 ATP-grasp domain; Region: ATP-grasp_4; cl03087 698737002463 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 698737002464 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 698737002465 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 698737002466 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 698737002467 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 698737002468 CTP synthetase; Validated; Region: pyrG; PRK05380 698737002469 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 698737002470 Catalytic site [active] 698737002471 active site 698737002472 UTP binding site [chemical binding]; other site 698737002473 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 698737002474 active site 698737002475 putative oxyanion hole; other site 698737002476 catalytic triad [active] 698737002477 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 698737002478 hypothetical protein; Provisional; Region: PRK08185 698737002479 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 698737002480 intersubunit interface [polypeptide binding]; other site 698737002481 active site 698737002482 zinc binding site [ion binding]; other site 698737002483 Na+ binding site [ion binding]; other site 698737002484 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 698737002485 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 698737002486 hinge; other site 698737002487 active site 698737002488 Helix-turn-helix domains; Region: HTH; cl00088 698737002489 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 698737002490 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698737002491 NAD binding site [chemical binding]; other site 698737002492 catalytic residues [active] 698737002493 transcription termination factor Rho; Provisional; Region: rho; PRK09376 698737002494 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 698737002495 RNA binding site [nucleotide binding]; other site 698737002496 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 698737002497 multimer interface [polypeptide binding]; other site 698737002498 Walker A motif; other site 698737002499 ATP binding site [chemical binding]; other site 698737002500 Walker B motif; other site 698737002501 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 698737002502 thymidine kinase; Provisional; Region: PRK04296 698737002503 peptide chain release factor 1; Validated; Region: prfA; PRK00591 698737002504 RF-1 domain; Region: RF-1; cl02875 698737002505 RF-1 domain; Region: RF-1; cl02875 698737002506 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 698737002507 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698737002508 S-adenosylmethionine binding site [chemical binding]; other site 698737002509 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 698737002510 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 698737002511 Low molecular weight phosphatase family; Region: LMWPc; cd00115 698737002512 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 698737002513 active site 698737002514 Protein of unknown function (DUF436); Region: DUF436; cl01860 698737002515 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 698737002516 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 698737002517 dimer interface [polypeptide binding]; other site 698737002518 glycine-pyridoxal phosphate binding site [chemical binding]; other site 698737002519 active site 698737002520 folate binding site [chemical binding]; other site 698737002521 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698737002522 active site 698737002523 ATP synthase A chain; Region: ATP-synt_A; cl00413 698737002524 ATP synthase subunit C; Region: ATP-synt_C; cl00466 698737002525 Plant ATP synthase F0; Region: YMF19; cl07975 698737002526 Plant ATP synthase F0; Region: YMF19; cl07975 698737002527 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 698737002528 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 698737002529 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 698737002530 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 698737002531 beta subunit interaction interface [polypeptide binding]; other site 698737002532 Walker A motif; other site 698737002533 ATP binding site [chemical binding]; other site 698737002534 Walker B motif; other site 698737002535 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 698737002536 ATP synthase; Region: ATP-synt; cl00365 698737002537 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 698737002538 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 698737002539 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 698737002540 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 698737002541 alpha subunit interaction interface [polypeptide binding]; other site 698737002542 Walker A motif; other site 698737002543 ATP binding site [chemical binding]; other site 698737002544 Walker B motif; other site 698737002545 inhibitor binding site; inhibition site 698737002546 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 698737002547 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 698737002548 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 698737002549 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 698737002550 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 698737002551 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 698737002552 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 698737002553 hinge; other site 698737002554 active site 698737002555 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 698737002556 YwpF-like protein; Region: YwpF; pfam14183 698737002557 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 698737002558 dimer interface [polypeptide binding]; other site 698737002559 ssDNA binding site [nucleotide binding]; other site 698737002560 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698737002561 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 698737002562 N-acetyl-D-glucosamine binding site [chemical binding]; other site 698737002563 catalytic residue [active] 698737002564 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 698737002565 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 698737002566 dimer interface [polypeptide binding]; other site 698737002567 substrate binding site [chemical binding]; other site 698737002568 ATP binding site [chemical binding]; other site 698737002569 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 698737002570 substrate binding site [chemical binding]; other site 698737002571 multimerization interface [polypeptide binding]; other site 698737002572 ATP binding site [chemical binding]; other site 698737002573 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 698737002574 thiamine phosphate binding site [chemical binding]; other site 698737002575 active site 698737002576 pyrophosphate binding site [ion binding]; other site 698737002577 OxaA-like protein precursor; Provisional; Region: PRK02463 698737002578 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 698737002579 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 698737002580 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 698737002581 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 698737002582 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 698737002583 putative active site [active] 698737002584 catalytic site [active] 698737002585 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 698737002586 putative active site [active] 698737002587 catalytic site [active] 698737002588 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 698737002589 putative homotetramer interface [polypeptide binding]; other site 698737002590 putative homodimer interface [polypeptide binding]; other site 698737002591 allosteric switch controlling residues; other site 698737002592 putative metal binding site [ion binding]; other site 698737002593 putative homodimer-homodimer interface [polypeptide binding]; other site 698737002594 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698737002595 metal-binding site [ion binding] 698737002596 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 698737002597 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 698737002598 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 698737002599 ATP-grasp domain; Region: ATP-grasp_4; cl03087 698737002600 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 698737002601 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698737002602 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698737002603 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698737002604 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 698737002605 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 698737002606 ATP binding site [chemical binding]; other site 698737002607 Mg++ binding site [ion binding]; other site 698737002608 motif III; other site 698737002609 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698737002610 nucleotide binding region [chemical binding]; other site 698737002611 ATP-binding site [chemical binding]; other site 698737002612 Bacterial PH domain; Region: DUF304; cl01348 698737002613 Predicted membrane protein [Function unknown]; Region: COG3428 698737002614 Bacterial PH domain; Region: DUF304; cl01348 698737002615 Bacterial PH domain; Region: DUF304; cl01348 698737002616 Bacterial PH domain; Region: DUF304; cl01348 698737002617 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 698737002618 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 698737002619 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 698737002620 active site 698737002621 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698737002622 dimer interface [polypeptide binding]; other site 698737002623 substrate binding site [chemical binding]; other site 698737002624 catalytic residues [active] 698737002625 PemK-like protein; Region: PemK; cl00995 698737002626 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 698737002627 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 698737002628 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 698737002629 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 698737002630 anti sigma factor interaction site; other site 698737002631 regulatory phosphorylation site [posttranslational modification]; other site 698737002632 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 698737002633 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737002634 ATP binding site [chemical binding]; other site 698737002635 Mg2+ binding site [ion binding]; other site 698737002636 G-X-G motif; other site 698737002637 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 698737002638 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698737002639 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 698737002640 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698737002641 DNA binding residues [nucleotide binding] 698737002642 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 698737002643 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 698737002644 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 698737002645 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 698737002646 RNA binding site [nucleotide binding]; other site 698737002647 hypothetical protein; Provisional; Region: PRK04351 698737002648 SprT homologues; Region: SprT; cl01182 698737002649 LysE type translocator; Region: LysE; cl00565 698737002650 threonine dehydratase; Validated; Region: PRK08639 698737002651 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 698737002652 tetramer interface [polypeptide binding]; other site 698737002653 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737002654 catalytic residue [active] 698737002655 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 698737002656 putative Ile/Val binding site [chemical binding]; other site 698737002657 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 698737002658 substrate binding site [chemical binding]; other site 698737002659 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 698737002660 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 698737002661 substrate binding site [chemical binding]; other site 698737002662 ligand binding site [chemical binding]; other site 698737002663 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 698737002664 tartrate dehydrogenase; Provisional; Region: PRK08194 698737002665 2-isopropylmalate synthase; Validated; Region: PRK00915 698737002666 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 698737002667 active site 698737002668 catalytic residues [active] 698737002669 metal binding site [ion binding]; metal-binding site 698737002670 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 698737002671 ketol-acid reductoisomerase; Provisional; Region: PRK05479 698737002672 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737002673 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 698737002674 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 698737002675 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 698737002676 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 698737002677 PYR/PP interface [polypeptide binding]; other site 698737002678 dimer interface [polypeptide binding]; other site 698737002679 TPP binding site [chemical binding]; other site 698737002680 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 698737002681 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 698737002682 TPP-binding site [chemical binding]; other site 698737002683 dimer interface [polypeptide binding]; other site 698737002684 Dehydratase family; Region: ILVD_EDD; cl00340 698737002685 6-phosphogluconate dehydratase; Region: edd; TIGR01196 698737002686 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 698737002687 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 698737002688 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 698737002689 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698737002690 Coenzyme A binding pocket [chemical binding]; other site 698737002691 UGMP family protein; Validated; Region: PRK09604 698737002692 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 698737002693 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 698737002694 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737002695 Walker A/P-loop; other site 698737002696 ATP binding site [chemical binding]; other site 698737002697 Q-loop/lid; other site 698737002698 ABC transporter signature motif; other site 698737002699 Walker B; other site 698737002700 D-loop; other site 698737002701 H-loop/switch region; other site 698737002702 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698737002703 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 698737002704 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 698737002705 ABC transporter; Region: ABC_tran_2; pfam12848 698737002706 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 698737002707 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 698737002708 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 698737002709 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737002710 Sulphur transport; Region: Sulf_transp; cl01018 698737002711 putative inner membrane protein; Provisional; Region: PRK11099 698737002712 putative inner membrane protein; Provisional; Region: PRK11099 698737002713 Sulphur transport; Region: Sulf_transp; cl01018 698737002714 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 698737002715 CPxP motif; other site 698737002716 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 698737002717 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698737002718 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698737002719 DNA binding site [nucleotide binding] 698737002720 domain linker motif; other site 698737002721 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 698737002722 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 698737002723 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 698737002724 substrate binding [chemical binding]; other site 698737002725 active site 698737002726 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 698737002727 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 698737002728 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698737002729 putative substrate binding site [chemical binding]; other site 698737002730 putative ATP binding site [chemical binding]; other site 698737002731 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 698737002732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698737002733 active site 698737002734 phosphorylation site [posttranslational modification] 698737002735 intermolecular recognition site; other site 698737002736 dimerization interface [polypeptide binding]; other site 698737002737 LytTr DNA-binding domain; Region: LytTR; cl04498 698737002738 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 698737002739 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 698737002740 Staphylococcal AgrD protein; Region: AgrD; cl05477 698737002741 Accessory gene regulator B; Region: AgrB; cl01873 698737002742 Predicted amidohydrolase [General function prediction only]; Region: COG0388 698737002743 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 698737002744 putative active site [active] 698737002745 catalytic triad [active] 698737002746 putative dimer interface [polypeptide binding]; other site 698737002747 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 698737002748 dimer interface [polypeptide binding]; other site 698737002749 FMN binding site [chemical binding]; other site 698737002750 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 698737002751 CAAX protease self-immunity; Region: Abi; cl00558 698737002752 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 698737002753 oligomerisation interface [polypeptide binding]; other site 698737002754 mobile loop; other site 698737002755 roof hairpin; other site 698737002756 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 698737002757 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 698737002758 ring oligomerisation interface [polypeptide binding]; other site 698737002759 ATP/Mg binding site [chemical binding]; other site 698737002760 stacking interactions; other site 698737002761 hinge regions; other site 698737002762 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 698737002763 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698737002764 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737002765 homodimer interface [polypeptide binding]; other site 698737002766 catalytic residue [active] 698737002767 Predicted transcriptional regulators [Transcription]; Region: COG1725 698737002768 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698737002769 DNA-binding site [nucleotide binding]; DNA binding site 698737002770 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698737002771 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 698737002772 Walker A/P-loop; other site 698737002773 ATP binding site [chemical binding]; other site 698737002774 Q-loop/lid; other site 698737002775 ABC transporter signature motif; other site 698737002776 Walker B; other site 698737002777 D-loop; other site 698737002778 H-loop/switch region; other site 698737002779 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 698737002780 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698737002781 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737002782 Walker A/P-loop; other site 698737002783 ATP binding site [chemical binding]; other site 698737002784 Q-loop/lid; other site 698737002785 ABC transporter signature motif; other site 698737002786 Walker B; other site 698737002787 D-loop; other site 698737002788 H-loop/switch region; other site 698737002789 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698737002790 catalytic residues [active] 698737002791 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 698737002792 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 698737002793 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 698737002794 active site 698737002795 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 698737002796 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 698737002797 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 698737002798 NAD(P) binding site [chemical binding]; other site 698737002799 catalytic residues [active] 698737002800 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 698737002801 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 698737002802 DHHA2 domain; Region: DHHA2; pfam02833 698737002803 Isochorismatase family; Region: Isochorismatase; pfam00857 698737002804 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 698737002805 catalytic triad [active] 698737002806 conserved cis-peptide bond; other site 698737002807 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 698737002808 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 698737002809 transmembrane helices; other site 698737002810 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 698737002811 Prephenate dehydratase; Region: PDT; pfam00800 698737002812 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 698737002813 putative L-Phe binding site [chemical binding]; other site 698737002814 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 698737002815 active site 698737002816 dimer interface [polypeptide binding]; other site 698737002817 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 698737002818 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 698737002819 active site 698737002820 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 698737002821 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 698737002822 homodimer interface [polypeptide binding]; other site 698737002823 NAD binding pocket [chemical binding]; other site 698737002824 ATP binding pocket [chemical binding]; other site 698737002825 Mg binding site [ion binding]; other site 698737002826 active-site loop [active] 698737002827 hypothetical protein; Provisional; Region: PRK04164 698737002828 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 698737002829 NETI protein; Region: NETI; pfam14044 698737002830 adenylosuccinate lyase; Provisional; Region: PRK07492 698737002831 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 698737002832 tetramer interface [polypeptide binding]; other site 698737002833 active site 698737002834 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 698737002835 Helix-turn-helix domains; Region: HTH; cl00088 698737002836 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 698737002837 substrate binding site [chemical binding]; other site 698737002838 putative active site [active] 698737002839 dimer interface [polypeptide binding]; other site 698737002840 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 698737002841 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737002842 Family description; Region: UvrD_C_2; cl15862 698737002843 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 698737002844 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 698737002845 nucleotide binding pocket [chemical binding]; other site 698737002846 K-X-D-G motif; other site 698737002847 catalytic site [active] 698737002848 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 698737002849 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 698737002850 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 698737002851 Dimer interface [polypeptide binding]; other site 698737002852 CamS sex pheromone cAM373 precursor; Region: CamS; cl11554 698737002853 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698737002854 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 698737002855 active site 698737002856 metal binding site [ion binding]; metal-binding site 698737002857 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 698737002858 Sodium:solute symporter family; Region: SSF; cl00456 698737002859 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 698737002860 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 698737002861 Amidase; Region: Amidase; cl11426 698737002862 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 698737002863 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 698737002864 GatB domain; Region: GatB_Yqey; cl11497 698737002865 putative lipid kinase; Reviewed; Region: PRK13337 698737002866 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 698737002867 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 698737002868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698737002869 S-adenosylmethionine binding site [chemical binding]; other site 698737002870 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 698737002871 TfoX N-terminal domain; Region: TfoX_N; cl01167 698737002872 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 698737002873 active site 698737002874 DNA polymerase IV; Validated; Region: PRK02406 698737002875 DNA binding site [nucleotide binding] 698737002876 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 698737002877 active site 698737002878 substrate binding site [chemical binding]; other site 698737002879 catalytic site [active] 698737002880 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 698737002881 Ferritin-like domain; Region: Ferritin; pfam00210 698737002882 ferroxidase diiron center [ion binding]; other site 698737002883 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 698737002884 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698737002885 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 698737002886 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 698737002887 catalytic triad [active] 698737002888 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 698737002889 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698737002890 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698737002891 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 698737002892 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 698737002893 active site 698737002894 Predicted membrane protein [Function unknown]; Region: COG4758 698737002895 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 698737002896 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 698737002897 Histidine kinase; Region: HisKA_3; pfam07730 698737002898 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737002899 ATP binding site [chemical binding]; other site 698737002900 Mg2+ binding site [ion binding]; other site 698737002901 G-X-G motif; other site 698737002902 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698737002903 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698737002904 active site 698737002905 phosphorylation site [posttranslational modification] 698737002906 intermolecular recognition site; other site 698737002907 dimerization interface [polypeptide binding]; other site 698737002908 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698737002909 DNA binding residues [nucleotide binding] 698737002910 dimerization interface [polypeptide binding]; other site 698737002911 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 698737002912 Low molecular weight phosphatase family; Region: LMWPc; cd00115 698737002913 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 698737002914 active site 698737002915 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 698737002916 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 698737002917 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 698737002918 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698737002919 FeS/SAM binding site; other site 698737002920 YfkB-like domain; Region: YfkB; pfam08756 698737002921 intracellular protease, PfpI family; Region: PfpI; TIGR01382 698737002922 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 698737002923 proposed catalytic triad [active] 698737002924 conserved cys residue [active] 698737002925 Transglycosylase; Region: Transgly; cl07896 698737002926 RecX family; Region: RecX; cl00936 698737002927 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 698737002928 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 698737002929 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737002930 Walker A/P-loop; other site 698737002931 ATP binding site [chemical binding]; other site 698737002932 Q-loop/lid; other site 698737002933 ABC transporter signature motif; other site 698737002934 Walker B; other site 698737002935 D-loop; other site 698737002936 H-loop/switch region; other site 698737002937 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 698737002938 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 698737002939 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 698737002940 minor groove reading motif; other site 698737002941 helix-hairpin-helix signature motif; other site 698737002942 substrate binding pocket [chemical binding]; other site 698737002943 active site 698737002944 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 698737002945 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 698737002946 DNA binding and oxoG recognition site [nucleotide binding] 698737002947 Protein of unknown function (DUF402); Region: DUF402; cl00979 698737002948 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698737002949 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 698737002950 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 698737002951 Walker A/P-loop; other site 698737002952 ATP binding site [chemical binding]; other site 698737002953 Q-loop/lid; other site 698737002954 ABC transporter signature motif; other site 698737002955 Walker B; other site 698737002956 D-loop; other site 698737002957 H-loop/switch region; other site 698737002958 Predicted membrane protein [Function unknown]; Region: COG4129 698737002959 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 698737002960 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 698737002961 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698737002962 inhibitor-cofactor binding pocket; inhibition site 698737002963 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737002964 catalytic residue [active] 698737002965 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 698737002966 catalytic triad [active] 698737002967 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 698737002968 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737002969 ferric uptake regulator; Provisional; Region: fur; PRK09462 698737002970 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 698737002971 metal binding site 2 [ion binding]; metal-binding site 698737002972 putative DNA binding helix; other site 698737002973 metal binding site 1 [ion binding]; metal-binding site 698737002974 dimer interface [polypeptide binding]; other site 698737002975 structural Zn2+ binding site [ion binding]; other site 698737002976 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 698737002977 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 698737002978 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698737002979 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698737002980 substrate binding pocket [chemical binding]; other site 698737002981 membrane-bound complex binding site; other site 698737002982 hinge residues; other site 698737002983 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698737002984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737002985 dimer interface [polypeptide binding]; other site 698737002986 conserved gate region; other site 698737002987 putative PBP binding loops; other site 698737002988 ABC-ATPase subunit interface; other site 698737002989 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698737002990 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 698737002991 Walker A/P-loop; other site 698737002992 ATP binding site [chemical binding]; other site 698737002993 Q-loop/lid; other site 698737002994 ABC transporter signature motif; other site 698737002995 Walker B; other site 698737002996 D-loop; other site 698737002997 H-loop/switch region; other site 698737002998 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 698737002999 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 698737003000 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 698737003001 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 698737003002 active site 698737003003 fumarate hydratase; Reviewed; Region: fumC; PRK00485 698737003004 Class II fumarases; Region: Fumarase_classII; cd01362 698737003005 active site 698737003006 tetramer interface [polypeptide binding]; other site 698737003007 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 698737003008 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 698737003009 active site 698737003010 GAF domain; Region: GAF_2; pfam13185 698737003011 GAF domain; Region: GAF; cl15785 698737003012 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 698737003013 Histidine kinase; Region: HisKA_3; pfam07730 698737003014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737003015 ATP binding site [chemical binding]; other site 698737003016 Mg2+ binding site [ion binding]; other site 698737003017 G-X-G motif; other site 698737003018 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698737003019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698737003020 active site 698737003021 phosphorylation site [posttranslational modification] 698737003022 intermolecular recognition site; other site 698737003023 dimerization interface [polypeptide binding]; other site 698737003024 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698737003025 DNA binding residues [nucleotide binding] 698737003026 dimerization interface [polypeptide binding]; other site 698737003027 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698737003028 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698737003029 non-specific DNA binding site [nucleotide binding]; other site 698737003030 salt bridge; other site 698737003031 sequence-specific DNA binding site [nucleotide binding]; other site 698737003032 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 698737003033 Protein of unknown function (DUF964); Region: DUF964; cl01483 698737003034 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 698737003035 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 698737003036 active site 698737003037 metal binding site [ion binding]; metal-binding site 698737003038 DNA binding site [nucleotide binding] 698737003039 Uncharacterized conserved protein [Function unknown]; Region: COG4717 698737003040 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737003041 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 698737003042 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 698737003043 generic binding surface II; other site 698737003044 generic binding surface I; other site 698737003045 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698737003046 Zn2+ binding site [ion binding]; other site 698737003047 Mg2+ binding site [ion binding]; other site 698737003048 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698737003049 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 698737003050 PPIC-type PPIASE domain; Region: Rotamase; cl08278 698737003051 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 698737003052 YtxH-like protein; Region: YtxH; cl02079 698737003053 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 698737003054 HIT family signature motif; other site 698737003055 catalytic residue [active] 698737003056 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 698737003057 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 698737003058 Walker A/P-loop; other site 698737003059 ATP binding site [chemical binding]; other site 698737003060 Q-loop/lid; other site 698737003061 ABC transporter signature motif; other site 698737003062 Walker B; other site 698737003063 D-loop; other site 698737003064 H-loop/switch region; other site 698737003065 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 698737003066 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 698737003067 substrate binding site [chemical binding]; other site 698737003068 active site 698737003069 ferrochelatase; Provisional; Region: PRK12435 698737003070 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 698737003071 C-terminal domain interface [polypeptide binding]; other site 698737003072 active site 698737003073 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 698737003074 active site 698737003075 N-terminal domain interface [polypeptide binding]; other site 698737003076 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 698737003077 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737003078 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 698737003079 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 698737003080 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 698737003081 AMP-binding enzyme; Region: AMP-binding; cl15778 698737003082 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 698737003083 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 698737003084 metal binding site [ion binding]; metal-binding site 698737003085 substrate binding pocket [chemical binding]; other site 698737003086 Haemolytic domain; Region: Haemolytic; cl00506 698737003087 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 698737003088 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 698737003089 nudix motif; other site 698737003090 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 698737003091 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 698737003092 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 698737003093 active site 698737003094 substrate-binding site [chemical binding]; other site 698737003095 metal-binding site [ion binding] 698737003096 ATP binding site [chemical binding]; other site 698737003097 S-adenosylmethionine synthetase; Validated; Region: PRK05250 698737003098 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 698737003099 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 698737003100 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 698737003101 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698737003102 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698737003103 active site 698737003104 catalytic tetrad [active] 698737003105 CrcB-like protein; Region: CRCB; cl09114 698737003106 CrcB-like protein; Region: CRCB; cl09114 698737003107 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 698737003108 active site 698737003109 intersubunit interactions; other site 698737003110 catalytic residue [active] 698737003111 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 698737003112 Helix-turn-helix domains; Region: HTH; cl00088 698737003113 DNA binding residues [nucleotide binding] 698737003114 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 698737003115 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 698737003116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 698737003117 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737003118 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 698737003119 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 698737003120 catalytic motif [active] 698737003121 Zn binding site [ion binding]; other site 698737003122 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 698737003123 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 698737003124 Lumazine binding domain; Region: Lum_binding; pfam00677 698737003125 Lumazine binding domain; Region: Lum_binding; pfam00677 698737003126 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 698737003127 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 698737003128 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 698737003129 dimerization interface [polypeptide binding]; other site 698737003130 active site 698737003131 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 698737003132 homopentamer interface [polypeptide binding]; other site 698737003133 active site 698737003134 Proline dehydrogenase; Region: Pro_dh; cl03282 698737003135 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 698737003136 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 698737003137 Helix-turn-helix domains; Region: HTH; cl00088 698737003138 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737003139 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737003140 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 698737003141 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 698737003142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737003143 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698737003144 putative substrate translocation pore; other site 698737003145 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 698737003146 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 698737003147 HIGH motif; other site 698737003148 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 698737003149 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 698737003150 active site 698737003151 KMSKS motif; other site 698737003152 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 698737003153 tRNA binding surface [nucleotide binding]; other site 698737003154 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698737003155 active site residue [active] 698737003156 HI0933-like protein; Region: HI0933_like; pfam03486 698737003157 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737003158 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737003159 stage V sporulation protein B; Region: spore_V_B; TIGR02900 698737003160 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 698737003161 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698737003162 RNA binding surface [nucleotide binding]; other site 698737003163 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 698737003164 active site 698737003165 uracil binding [chemical binding]; other site 698737003166 YtxH-like protein; Region: YtxH; cl02079 698737003167 dipeptidase PepV; Reviewed; Region: PRK07318 698737003168 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 698737003169 active site 698737003170 metal binding site [ion binding]; metal-binding site 698737003171 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 698737003172 homodimer interface [polypeptide binding]; other site 698737003173 substrate-cofactor binding pocket; other site 698737003174 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737003175 catalytic residue [active] 698737003176 Phosphotransferase enzyme family; Region: APH; pfam01636 698737003177 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 698737003178 active site 698737003179 substrate binding site [chemical binding]; other site 698737003180 ATP binding site [chemical binding]; other site 698737003181 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 698737003182 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 698737003183 Predicted small secreted protein [Function unknown]; Region: COG5584 698737003184 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 698737003185 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 698737003186 oligomer interface [polypeptide binding]; other site 698737003187 active site 698737003188 metal binding site [ion binding]; metal-binding site 698737003189 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698737003190 catalytic residues [active] 698737003191 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 698737003192 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 698737003193 putative tRNA-binding site [nucleotide binding]; other site 698737003194 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 698737003195 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737003196 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 698737003197 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 698737003198 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698737003199 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698737003200 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698737003201 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 698737003202 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 698737003203 Chorismate mutase type II; Region: CM_2; cl00693 698737003204 NeuB family; Region: NeuB; cl00496 698737003205 catabolite control protein A; Region: ccpA; TIGR01481 698737003206 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698737003207 DNA binding site [nucleotide binding] 698737003208 domain linker motif; other site 698737003209 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 698737003210 dimerization interface [polypeptide binding]; other site 698737003211 effector binding site; other site 698737003212 Transposase domain (DUF772); Region: DUF772; cl15789 698737003213 acetoin reductase; Validated; Region: PRK08643 698737003214 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 698737003215 NAD binding site [chemical binding]; other site 698737003216 homotetramer interface [polypeptide binding]; other site 698737003217 homodimer interface [polypeptide binding]; other site 698737003218 active site 698737003219 substrate binding site [chemical binding]; other site 698737003220 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 698737003221 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 698737003222 acetyl-CoA synthetase; Provisional; Region: PRK04319 698737003223 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 698737003224 AMP-binding enzyme; Region: AMP-binding; cl15778 698737003225 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 698737003226 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 698737003227 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 698737003228 Potassium binding sites [ion binding]; other site 698737003229 Cesium cation binding sites [ion binding]; other site 698737003230 Transglycosylase; Region: Transgly; cl07896 698737003231 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 698737003232 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 698737003233 active site 698737003234 HIGH motif; other site 698737003235 dimer interface [polypeptide binding]; other site 698737003236 KMSKS motif; other site 698737003237 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698737003238 RNA binding surface [nucleotide binding]; other site 698737003239 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 698737003240 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 698737003241 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698737003242 protein binding site [polypeptide binding]; other site 698737003243 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 698737003244 putative acyl-acceptor binding pocket; other site 698737003245 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 698737003246 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 698737003247 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 698737003248 active site turn [active] 698737003249 phosphorylation site [posttranslational modification] 698737003250 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698737003251 motif II; other site 698737003252 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 698737003253 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737003254 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 698737003255 putative L-serine binding site [chemical binding]; other site 698737003256 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 698737003257 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698737003258 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698737003259 catalytic residue [active] 698737003260 OsmC-like protein; Region: OsmC; cl00767 698737003261 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 698737003262 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 698737003263 active site 698737003264 catalytic site [active] 698737003265 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 698737003266 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 698737003267 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698737003268 RNA binding surface [nucleotide binding]; other site 698737003269 GAF domain; Region: GAF; cl15785 698737003270 septation ring formation regulator EzrA; Provisional; Region: PRK04778 698737003271 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698737003272 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 698737003273 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698737003274 catalytic residue [active] 698737003275 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 698737003276 THUMP domain; Region: THUMP; cl12076 698737003277 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 698737003278 Ligand Binding Site [chemical binding]; other site 698737003279 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 698737003280 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 698737003281 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 698737003282 dimer interface [polypeptide binding]; other site 698737003283 catalytic triad [active] 698737003284 peroxidatic and resolving cysteines [active] 698737003285 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 698737003286 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737003287 Acetokinase family; Region: Acetate_kinase; cl01029 698737003288 propionate/acetate kinase; Provisional; Region: PRK12379 698737003289 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698737003290 Ligand Binding Site [chemical binding]; other site 698737003291 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 698737003292 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 698737003293 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737003294 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 698737003295 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698737003296 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 698737003297 active site 698737003298 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 698737003299 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698737003300 Ligand Binding Site [chemical binding]; other site 698737003301 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 698737003302 Helix-turn-helix domains; Region: HTH; cl00088 698737003303 DNA-binding site [nucleotide binding]; DNA binding site 698737003304 DRTGG domain; Region: DRTGG; cl12147 698737003305 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 698737003306 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 698737003307 DHH family; Region: DHH; pfam01368 698737003308 DHHA1 domain; Region: DHHA1; pfam02272 698737003309 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 698737003310 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 698737003311 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 698737003312 generic binding surface I; other site 698737003313 generic binding surface II; other site 698737003314 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 698737003315 Malic enzyme, N-terminal domain; Region: malic; pfam00390 698737003316 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 698737003317 putative NAD(P) binding site [chemical binding]; other site 698737003318 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 698737003319 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 698737003320 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 698737003321 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 698737003322 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 698737003323 active site 698737003324 ADP/pyrophosphate binding site [chemical binding]; other site 698737003325 dimerization interface [polypeptide binding]; other site 698737003326 allosteric effector site; other site 698737003327 fructose-1,6-bisphosphate binding site; other site 698737003328 pyruvate kinase; Provisional; Region: PRK06354 698737003329 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 698737003330 domain interfaces; other site 698737003331 active site 698737003332 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 698737003333 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 698737003334 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 698737003335 dimer interface [polypeptide binding]; other site 698737003336 Citrate synthase; Region: Citrate_synt; pfam00285 698737003337 active site 698737003338 citrylCoA binding site [chemical binding]; other site 698737003339 oxalacetate/citrate binding site [chemical binding]; other site 698737003340 coenzyme A binding site [chemical binding]; other site 698737003341 catalytic triad [active] 698737003342 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 698737003343 isocitrate dehydrogenase; Validated; Region: PRK07362 698737003344 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698737003345 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698737003346 active site 698737003347 phosphorylation site [posttranslational modification] 698737003348 intermolecular recognition site; other site 698737003349 dimerization interface [polypeptide binding]; other site 698737003350 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698737003351 DNA binding site [nucleotide binding] 698737003352 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 698737003353 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 698737003354 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698737003355 dimer interface [polypeptide binding]; other site 698737003356 phosphorylation site [posttranslational modification] 698737003357 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737003358 ATP binding site [chemical binding]; other site 698737003359 Mg2+ binding site [ion binding]; other site 698737003360 G-X-G motif; other site 698737003361 DNA polymerase I; Provisional; Region: PRK05755 698737003362 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 698737003363 active site 698737003364 metal binding site 1 [ion binding]; metal-binding site 698737003365 putative 5' ssDNA interaction site; other site 698737003366 metal binding site 3; metal-binding site 698737003367 metal binding site 2 [ion binding]; metal-binding site 698737003368 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 698737003369 putative DNA binding site [nucleotide binding]; other site 698737003370 putative metal binding site [ion binding]; other site 698737003371 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 698737003372 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 698737003373 active site 698737003374 DNA binding site [nucleotide binding] 698737003375 catalytic site [active] 698737003376 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 698737003377 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 698737003378 DNA binding site [nucleotide binding] 698737003379 catalytic residue [active] 698737003380 H2TH interface [polypeptide binding]; other site 698737003381 putative catalytic residues [active] 698737003382 turnover-facilitating residue; other site 698737003383 intercalation triad [nucleotide binding]; other site 698737003384 8OG recognition residue [nucleotide binding]; other site 698737003385 putative reading head residues; other site 698737003386 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698737003387 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 698737003388 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 698737003389 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 698737003390 CoA-binding site [chemical binding]; other site 698737003391 ATP-binding [chemical binding]; other site 698737003392 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 698737003393 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737003394 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 698737003395 biotin synthase; Validated; Region: PRK06256 698737003396 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698737003397 FeS/SAM binding site; other site 698737003398 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 698737003399 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 698737003400 ATP cone domain; Region: ATP-cone; pfam03477 698737003401 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 698737003402 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 698737003403 primosomal protein DnaI; Reviewed; Region: PRK08939 698737003404 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 698737003405 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698737003406 Walker A motif; other site 698737003407 ATP binding site [chemical binding]; other site 698737003408 Walker B motif; other site 698737003409 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 698737003410 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 698737003411 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 698737003412 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 698737003413 active site 698737003414 dimer interface [polypeptide binding]; other site 698737003415 motif 1; other site 698737003416 motif 2; other site 698737003417 motif 3; other site 698737003418 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 698737003419 anticodon binding site; other site 698737003420 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 698737003421 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 698737003422 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 698737003423 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 698737003424 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 698737003425 ribosomal protein L20; Region: rpl20; CHL00068 698737003426 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 698737003427 23S rRNA binding site [nucleotide binding]; other site 698737003428 L21 binding site [polypeptide binding]; other site 698737003429 L13 binding site [polypeptide binding]; other site 698737003430 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 698737003431 nudix motif; other site 698737003432 trigger factor; Provisional; Region: tig; PRK01490 698737003433 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 698737003434 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 698737003435 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 698737003436 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 698737003437 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737003438 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 698737003439 Predicted GTPase [General function prediction only]; Region: COG0218 698737003440 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 698737003441 G1 box; other site 698737003442 GTP/Mg2+ binding site [chemical binding]; other site 698737003443 Switch I region; other site 698737003444 G2 box; other site 698737003445 G3 box; other site 698737003446 Switch II region; other site 698737003447 G4 box; other site 698737003448 G5 box; other site 698737003449 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 698737003450 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 698737003451 tRNA; other site 698737003452 putative tRNA binding site [nucleotide binding]; other site 698737003453 putative NADP binding site [chemical binding]; other site 698737003454 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 698737003455 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 698737003456 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 698737003457 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 698737003458 domain interfaces; other site 698737003459 active site 698737003460 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 698737003461 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 698737003462 active site 698737003463 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 698737003464 dimer interface [polypeptide binding]; other site 698737003465 active site 698737003466 Schiff base residues; other site 698737003467 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 698737003468 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698737003469 inhibitor-cofactor binding pocket; inhibition site 698737003470 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737003471 catalytic residue [active] 698737003472 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 698737003473 Putative ammonia monooxygenase; Region: AmoA; pfam05145 698737003474 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 698737003475 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 698737003476 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 698737003477 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698737003478 active site 698737003479 HIGH motif; other site 698737003480 nucleotide binding site [chemical binding]; other site 698737003481 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 698737003482 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 698737003483 active site 698737003484 KMSKS motif; other site 698737003485 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 698737003486 tRNA binding surface [nucleotide binding]; other site 698737003487 anticodon binding site; other site 698737003488 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 698737003489 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 698737003490 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698737003491 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698737003492 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 698737003493 hypothetical protein; Reviewed; Region: PRK00024 698737003494 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 698737003495 MPN+ (JAMM) motif; other site 698737003496 Zinc-binding site [ion binding]; other site 698737003497 rod shape-determining protein MreC; Provisional; Region: PRK13922 698737003498 rod shape-determining protein MreC; Region: MreC; pfam04085 698737003499 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 698737003500 Protein of unknown function (DUF464); Region: DUF464; cl01080 698737003501 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 698737003502 GTPase CgtA; Reviewed; Region: obgE; PRK12297 698737003503 GTP1/OBG; Region: GTP1_OBG; pfam01018 698737003504 Obg GTPase; Region: Obg; cd01898 698737003505 G1 box; other site 698737003506 GTP/Mg2+ binding site [chemical binding]; other site 698737003507 Switch I region; other site 698737003508 G2 box; other site 698737003509 G3 box; other site 698737003510 Switch II region; other site 698737003511 G4 box; other site 698737003512 G5 box; other site 698737003513 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 698737003514 hypothetical protein; Provisional; Region: PRK04435 698737003515 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 698737003516 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 698737003517 RuvA N terminal domain; Region: RuvA_N; pfam01330 698737003518 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 698737003519 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698737003520 Walker A motif; other site 698737003521 ATP binding site [chemical binding]; other site 698737003522 Walker B motif; other site 698737003523 arginine finger; other site 698737003524 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 698737003525 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 698737003526 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 698737003527 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 698737003528 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 698737003529 Preprotein translocase subunit; Region: YajC; cl00806 698737003530 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 698737003531 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 698737003532 Protein export membrane protein; Region: SecD_SecF; cl14618 698737003533 Protein export membrane protein; Region: SecD_SecF; cl14618 698737003534 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 698737003535 DHH family; Region: DHH; pfam01368 698737003536 DHHA1 domain; Region: DHHA1; pfam02272 698737003537 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 698737003538 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 698737003539 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698737003540 active site 698737003541 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 698737003542 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 698737003543 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 698737003544 synthetase active site [active] 698737003545 NTP binding site [chemical binding]; other site 698737003546 metal binding site [ion binding]; metal-binding site 698737003547 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 698737003548 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 698737003549 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 698737003550 putative active site [active] 698737003551 dimerization interface [polypeptide binding]; other site 698737003552 putative tRNAtyr binding site [nucleotide binding]; other site 698737003553 Bacterial SH3 domain; Region: SH3_3; cl02551 698737003554 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 698737003555 active site 698737003556 metal binding site [ion binding]; metal-binding site 698737003557 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 698737003558 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 698737003559 dimer interface [polypeptide binding]; other site 698737003560 motif 1; other site 698737003561 active site 698737003562 motif 2; other site 698737003563 motif 3; other site 698737003564 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 698737003565 anticodon binding site; other site 698737003566 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 698737003567 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 698737003568 dimer interface [polypeptide binding]; other site 698737003569 anticodon binding site; other site 698737003570 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 698737003571 homodimer interface [polypeptide binding]; other site 698737003572 motif 1; other site 698737003573 active site 698737003574 motif 2; other site 698737003575 GAD domain; Region: GAD; pfam02938 698737003576 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 698737003577 motif 3; other site 698737003578 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 698737003579 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 698737003580 putative ATP binding site [chemical binding]; other site 698737003581 putative substrate interface [chemical binding]; other site 698737003582 recombination factor protein RarA; Reviewed; Region: PRK13342 698737003583 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698737003584 Walker A motif; other site 698737003585 ATP binding site [chemical binding]; other site 698737003586 Walker B motif; other site 698737003587 arginine finger; other site 698737003588 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 698737003589 Predicted transcriptional regulator [Transcription]; Region: COG1959 698737003590 Helix-turn-helix domains; Region: HTH; cl00088 698737003591 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 698737003592 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 698737003593 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698737003594 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 698737003595 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698737003596 catalytic residue [active] 698737003597 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 698737003598 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 698737003599 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698737003600 TPR motif; other site 698737003601 binding surface 698737003602 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698737003603 binding surface 698737003604 TPR motif; other site 698737003605 TPR repeat; Region: TPR_11; pfam13414 698737003606 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 698737003607 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737003608 Family description; Region: UvrD_C_2; cl15862 698737003609 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 698737003610 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 698737003611 motif 1; other site 698737003612 active site 698737003613 motif 2; other site 698737003614 motif 3; other site 698737003615 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 698737003616 DHHA1 domain; Region: DHHA1; pfam02272 698737003617 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 698737003618 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 698737003619 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 698737003620 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 698737003621 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698737003622 S-adenosylmethionine binding site [chemical binding]; other site 698737003623 Peptidase family U32; Region: Peptidase_U32; cl03113 698737003624 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 698737003625 Peptidase family U32; Region: Peptidase_U32; cl03113 698737003626 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 698737003627 Sugar specificity; other site 698737003628 Pyrimidine base specificity; other site 698737003629 ATP-binding site [chemical binding]; other site 698737003630 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 698737003631 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 698737003632 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 698737003633 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 698737003634 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 698737003635 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 698737003636 acetyl-CoA carboxylase, biotin carboxyl carrier protein; Region: BCCP; TIGR00531 698737003637 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698737003638 carboxyltransferase (CT) interaction site; other site 698737003639 biotinylation site [posttranslational modification]; other site 698737003640 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698737003641 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 698737003642 ATP-grasp domain; Region: ATP-grasp_4; cl03087 698737003643 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 698737003644 LamB/YcsF family; Region: LamB_YcsF; cl00664 698737003645 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 698737003646 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 698737003647 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 698737003648 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698737003649 active site 698737003650 motif I; other site 698737003651 motif II; other site 698737003652 GTPase YqeH; Provisional; Region: PRK13796 698737003653 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 698737003654 GTP/Mg2+ binding site [chemical binding]; other site 698737003655 G4 box; other site 698737003656 G5 box; other site 698737003657 G1 box; other site 698737003658 Switch I region; other site 698737003659 G2 box; other site 698737003660 G3 box; other site 698737003661 Switch II region; other site 698737003662 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 698737003663 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 698737003664 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 698737003665 shikimate binding site; other site 698737003666 NAD(P) binding site [chemical binding]; other site 698737003667 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 698737003668 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 698737003669 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 698737003670 active site 698737003671 (T/H)XGH motif; other site 698737003672 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 698737003673 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698737003674 Zn2+ binding site [ion binding]; other site 698737003675 Mg2+ binding site [ion binding]; other site 698737003676 Oligomerisation domain; Region: Oligomerisation; cl00519 698737003677 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 698737003678 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698737003679 S-adenosylmethionine binding site [chemical binding]; other site 698737003680 SLBB domain; Region: SLBB; pfam10531 698737003681 comEA protein; Region: comE; TIGR01259 698737003682 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 698737003683 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 698737003684 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 698737003685 catalytic motif [active] 698737003686 Zn binding site [ion binding]; other site 698737003687 Competence protein; Region: Competence; cl00471 698737003688 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 698737003689 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 698737003690 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 698737003691 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 698737003692 GTP-binding protein LepA; Provisional; Region: PRK05433 698737003693 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 698737003694 G1 box; other site 698737003695 putative GEF interaction site [polypeptide binding]; other site 698737003696 GTP/Mg2+ binding site [chemical binding]; other site 698737003697 Switch I region; other site 698737003698 G2 box; other site 698737003699 G3 box; other site 698737003700 Switch II region; other site 698737003701 G4 box; other site 698737003702 G5 box; other site 698737003703 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 698737003704 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 698737003705 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 698737003706 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 698737003707 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698737003708 FeS/SAM binding site; other site 698737003709 HemN C-terminal domain; Region: HemN_C; pfam06969 698737003710 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 698737003711 HrcA protein C terminal domain; Region: HrcA; pfam01628 698737003712 heat shock protein GrpE; Provisional; Region: PRK14140 698737003713 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 698737003714 dimer interface [polypeptide binding]; other site 698737003715 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 698737003716 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 698737003717 chaperone protein DnaJ; Provisional; Region: PRK14280 698737003718 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 698737003719 HSP70 interaction site [polypeptide binding]; other site 698737003720 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 698737003721 substrate binding site [polypeptide binding]; other site 698737003722 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 698737003723 Zn binding sites [ion binding]; other site 698737003724 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 698737003725 dimer interface [polypeptide binding]; other site 698737003726 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 698737003727 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737003728 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 698737003729 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 698737003730 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 698737003731 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 698737003732 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698737003733 FeS/SAM binding site; other site 698737003734 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 698737003735 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 698737003736 SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057 698737003737 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 698737003738 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737003739 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 698737003740 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 698737003741 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 698737003742 active site 698737003743 catalytic motif [active] 698737003744 Zn binding site [ion binding]; other site 698737003745 GTPase Era; Reviewed; Region: era; PRK00089 698737003746 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 698737003747 G1 box; other site 698737003748 GTP/Mg2+ binding site [chemical binding]; other site 698737003749 Switch I region; other site 698737003750 G2 box; other site 698737003751 Switch II region; other site 698737003752 G3 box; other site 698737003753 G4 box; other site 698737003754 G5 box; other site 698737003755 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 698737003756 DNA repair protein RecO; Region: reco; TIGR00613 698737003757 Recombination protein O N terminal; Region: RecO_N; cl15812 698737003758 Recombination protein O C terminal; Region: RecO_C; pfam02565 698737003759 glycyl-tRNA synthetase; Provisional; Region: PRK04173 698737003760 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 698737003761 motif 1; other site 698737003762 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774 698737003763 active site 698737003764 motif 2; other site 698737003765 motif 3; other site 698737003766 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 698737003767 anticodon binding site; other site 698737003768 FOG: CBS domain [General function prediction only]; Region: COG0517 698737003769 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 698737003770 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 698737003771 DNA primase; Validated; Region: dnaG; PRK05667 698737003772 CHC2 zinc finger; Region: zf-CHC2; cl15369 698737003773 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 698737003774 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 698737003775 active site 698737003776 metal binding site [ion binding]; metal-binding site 698737003777 interdomain interaction site; other site 698737003778 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 698737003779 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 698737003780 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 698737003781 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698737003782 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 698737003783 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698737003784 DNA binding residues [nucleotide binding] 698737003785 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737003786 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 698737003787 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 698737003788 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 698737003789 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 698737003790 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 698737003791 ATP binding site [chemical binding]; other site 698737003792 Mg++ binding site [ion binding]; other site 698737003793 motif III; other site 698737003794 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698737003795 nucleotide binding region [chemical binding]; other site 698737003796 ATP-binding site [chemical binding]; other site 698737003797 endonuclease IV; Provisional; Region: PRK01060 698737003798 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 698737003799 AP (apurinic/apyrimidinic) site pocket; other site 698737003800 DNA interaction; other site 698737003801 Metal-binding active site; metal-binding site 698737003802 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698737003803 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 698737003804 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698737003805 ABC-ATPase subunit interface; other site 698737003806 dimer interface [polypeptide binding]; other site 698737003807 putative PBP binding regions; other site 698737003808 ferric uptake regulator; Provisional; Region: fur; PRK09462 698737003809 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 698737003810 metal binding site 2 [ion binding]; metal-binding site 698737003811 putative DNA binding helix; other site 698737003812 metal binding site 1 [ion binding]; metal-binding site 698737003813 dimer interface [polypeptide binding]; other site 698737003814 structural Zn2+ binding site [ion binding]; other site 698737003815 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 698737003816 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 698737003817 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 698737003818 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 698737003819 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 698737003820 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 698737003821 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 698737003822 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 698737003823 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 698737003824 Rhomboid family; Region: Rhomboid; cl11446 698737003825 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698737003826 binding surface 698737003827 TPR motif; other site 698737003828 TPR repeat; Region: TPR_11; pfam13414 698737003829 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 698737003830 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 698737003831 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 698737003832 Domain of unknown function DUF77; Region: DUF77; cl00307 698737003833 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 698737003834 Type II/IV secretion system protein; Region: T2SE; pfam00437 698737003835 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737003836 Walker A motif; other site 698737003837 ATP binding site [chemical binding]; other site 698737003838 Walker B motif; other site 698737003839 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 698737003840 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 698737003841 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 698737003842 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 698737003843 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 698737003844 ADP binding site [chemical binding]; other site 698737003845 magnesium binding site [ion binding]; other site 698737003846 putative shikimate binding site; other site 698737003847 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 698737003848 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 698737003849 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 698737003850 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 698737003851 tetramer interface [polypeptide binding]; other site 698737003852 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737003853 catalytic residue [active] 698737003854 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 698737003855 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 698737003856 tetramer interface [polypeptide binding]; other site 698737003857 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737003858 catalytic residue [active] 698737003859 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698737003860 active site residue [active] 698737003861 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 698737003862 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 698737003863 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 698737003864 aminopeptidase; Provisional; Region: PRK09795 698737003865 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698737003866 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 698737003867 active site 698737003868 elongation factor P; Validated; Region: PRK00529 698737003869 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 698737003870 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 698737003871 RNA binding site [nucleotide binding]; other site 698737003872 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 698737003873 RNA binding site [nucleotide binding]; other site 698737003874 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 698737003875 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698737003876 carboxyltransferase (CT) interaction site; other site 698737003877 biotinylation site [posttranslational modification]; other site 698737003878 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 698737003879 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698737003880 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 698737003881 Asp23 family; Region: Asp23; cl00574 698737003882 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 698737003883 putative RNA binding site [nucleotide binding]; other site 698737003884 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 698737003885 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 698737003886 generic binding surface II; other site 698737003887 generic binding surface I; other site 698737003888 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 698737003889 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 698737003890 substrate binding pocket [chemical binding]; other site 698737003891 chain length determination region; other site 698737003892 substrate-Mg2+ binding site; other site 698737003893 catalytic residues [active] 698737003894 aspartate-rich region 1; other site 698737003895 active site lid residues [active] 698737003896 aspartate-rich region 2; other site 698737003897 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 698737003898 arginine repressor; Provisional; Region: PRK04280 698737003899 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 698737003900 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 698737003901 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 698737003902 Walker A/P-loop; other site 698737003903 ATP binding site [chemical binding]; other site 698737003904 Q-loop/lid; other site 698737003905 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 698737003906 ABC transporter signature motif; other site 698737003907 Walker B; other site 698737003908 D-loop; other site 698737003909 H-loop/switch region; other site 698737003910 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 698737003911 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 698737003912 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 698737003913 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737003914 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698737003915 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698737003916 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 698737003917 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 698737003918 tetramer interface [polypeptide binding]; other site 698737003919 TPP-binding site [chemical binding]; other site 698737003920 heterodimer interface [polypeptide binding]; other site 698737003921 phosphorylation loop region [posttranslational modification] 698737003922 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 698737003923 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 698737003924 alpha subunit interface [polypeptide binding]; other site 698737003925 TPP binding site [chemical binding]; other site 698737003926 heterodimer interface [polypeptide binding]; other site 698737003927 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698737003928 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698737003929 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 698737003930 E3 interaction surface; other site 698737003931 lipoyl attachment site [posttranslational modification]; other site 698737003932 e3 binding domain; Region: E3_binding; pfam02817 698737003933 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 698737003934 Disulphide isomerase; Region: Disulph_isomer; pfam06491 698737003935 Predicted membrane protein [Function unknown]; Region: COG4129 698737003936 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 698737003937 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 698737003938 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 698737003939 peptidase T-like protein; Region: PepT-like; TIGR01883 698737003940 metal binding site [ion binding]; metal-binding site 698737003941 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737003942 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 698737003943 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 698737003944 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698737003945 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698737003946 DNA binding site [nucleotide binding] 698737003947 domain linker motif; other site 698737003948 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 698737003949 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 698737003950 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 698737003951 Ca binding site [ion binding]; other site 698737003952 active site 698737003953 catalytic site [active] 698737003954 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 698737003955 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 698737003956 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 698737003957 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 698737003958 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 698737003959 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 698737003960 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737003961 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 698737003962 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698737003963 classical (c) SDRs; Region: SDR_c; cd05233 698737003964 NAD(P) binding site [chemical binding]; other site 698737003965 active site 698737003966 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 698737003967 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698737003968 active site 698737003969 catalytic tetrad [active] 698737003970 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 698737003971 dimer interface [polypeptide binding]; other site 698737003972 ADP-ribose binding site [chemical binding]; other site 698737003973 active site 698737003974 nudix motif; other site 698737003975 metal binding site [ion binding]; metal-binding site 698737003976 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 698737003977 metal binding site 2 [ion binding]; metal-binding site 698737003978 putative DNA binding helix; other site 698737003979 metal binding site 1 [ion binding]; metal-binding site 698737003980 dimer interface [polypeptide binding]; other site 698737003981 structural Zn2+ binding site [ion binding]; other site 698737003982 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 698737003983 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 698737003984 Int/Topo IB signature motif; other site 698737003985 active site 698737003986 Domain of unknown function (DUF309); Region: DUF309; cl00667 698737003987 ScpA/B protein; Region: ScpA_ScpB; cl00598 698737003988 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 698737003989 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 698737003990 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698737003991 RNA binding surface [nucleotide binding]; other site 698737003992 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 698737003993 active site 698737003994 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 698737003995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698737003996 active site 698737003997 phosphorylation site [posttranslational modification] 698737003998 intermolecular recognition site; other site 698737003999 dimerization interface [polypeptide binding]; other site 698737004000 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698737004001 DNA binding site [nucleotide binding] 698737004002 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698737004003 dimerization interface [polypeptide binding]; other site 698737004004 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 698737004005 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 698737004006 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698737004007 dimer interface [polypeptide binding]; other site 698737004008 phosphorylation site [posttranslational modification] 698737004009 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737004010 ATP binding site [chemical binding]; other site 698737004011 Mg2+ binding site [ion binding]; other site 698737004012 G-X-G motif; other site 698737004013 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 698737004014 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 698737004015 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 698737004016 DEAD-like helicases superfamily; Region: DEXDc; smart00487 698737004017 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698737004018 ATP binding site [chemical binding]; other site 698737004019 putative Mg++ binding site [ion binding]; other site 698737004020 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698737004021 nucleotide binding region [chemical binding]; other site 698737004022 ATP-binding site [chemical binding]; other site 698737004023 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 698737004024 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 698737004025 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737004026 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698737004027 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698737004028 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 698737004029 active site 698737004030 homotetramer interface [polypeptide binding]; other site 698737004031 homodimer interface [polypeptide binding]; other site 698737004032 cytidylate kinase; Provisional; Region: cmk; PRK00023 698737004033 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 698737004034 CMP-binding site; other site 698737004035 The sites determining sugar specificity; other site 698737004036 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 698737004037 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 698737004038 RNA binding site [nucleotide binding]; other site 698737004039 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 698737004040 RNA binding site [nucleotide binding]; other site 698737004041 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698737004042 RNA binding site [nucleotide binding]; other site 698737004043 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 698737004044 RNA binding site [nucleotide binding]; other site 698737004045 GTP-binding protein Der; Reviewed; Region: PRK00093 698737004046 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 698737004047 G1 box; other site 698737004048 GTP/Mg2+ binding site [chemical binding]; other site 698737004049 Switch I region; other site 698737004050 G2 box; other site 698737004051 Switch II region; other site 698737004052 G3 box; other site 698737004053 G4 box; other site 698737004054 G5 box; other site 698737004055 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 698737004056 G1 box; other site 698737004057 GTP/Mg2+ binding site [chemical binding]; other site 698737004058 Switch I region; other site 698737004059 G2 box; other site 698737004060 G3 box; other site 698737004061 Switch II region; other site 698737004062 G4 box; other site 698737004063 G5 box; other site 698737004064 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 698737004065 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737004066 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 698737004067 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 698737004068 IHF dimer interface [polypeptide binding]; other site 698737004069 IHF - DNA interface [nucleotide binding]; other site 698737004070 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 698737004071 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698737004072 S-adenosylmethionine binding site [chemical binding]; other site 698737004073 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 698737004074 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 698737004075 substrate binding pocket [chemical binding]; other site 698737004076 chain length determination region; other site 698737004077 substrate-Mg2+ binding site; other site 698737004078 catalytic residues [active] 698737004079 aspartate-rich region 1; other site 698737004080 active site lid residues [active] 698737004081 aspartate-rich region 2; other site 698737004082 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 698737004083 active site 698737004084 multimer interface [polypeptide binding]; other site 698737004085 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 698737004086 Tetramer interface [polypeptide binding]; other site 698737004087 active site 698737004088 FMN-binding site [chemical binding]; other site 698737004089 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 698737004090 active site 698737004091 dimer interface [polypeptide binding]; other site 698737004092 metal binding site [ion binding]; metal-binding site 698737004093 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 698737004094 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 698737004095 hinge; other site 698737004096 active site 698737004097 Vi polysaccharide biosynthesis protein TviE; Provisional; Region: PRK15179 698737004098 tetratricopeptide repeat protein; Provisional; Region: PRK11788 698737004099 Uncharacterized conserved protein [Function unknown]; Region: COG5582 698737004100 UPF0302 domain; Region: UPF0302; pfam08864 698737004101 IDEAL domain; Region: IDEAL; cl07452 698737004102 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 698737004103 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 698737004104 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 698737004105 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 698737004106 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 698737004107 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 698737004108 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 698737004109 active site 698737004110 NTP binding site [chemical binding]; other site 698737004111 metal binding triad [ion binding]; metal-binding site 698737004112 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 698737004113 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 698737004114 Helix-turn-helix domains; Region: HTH; cl00088 698737004115 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 698737004116 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 698737004117 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 698737004118 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 698737004119 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 698737004120 active site 698737004121 substrate binding site [chemical binding]; other site 698737004122 catalytic site [active] 698737004123 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737004124 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737004125 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 698737004126 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 698737004127 putative dimer interface [polypeptide binding]; other site 698737004128 putative anticodon binding site; other site 698737004129 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 698737004130 homodimer interface [polypeptide binding]; other site 698737004131 motif 1; other site 698737004132 motif 2; other site 698737004133 active site 698737004134 motif 3; other site 698737004135 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 698737004136 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 698737004137 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 698737004138 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 698737004139 minor groove reading motif; other site 698737004140 helix-hairpin-helix signature motif; other site 698737004141 substrate binding pocket [chemical binding]; other site 698737004142 active site 698737004143 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 698737004144 Transglycosylase; Region: Transgly; cl07896 698737004145 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 698737004146 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 698737004147 Recombination protein U; Region: RecU; cl01314 698737004148 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 698737004149 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 698737004150 cell division protein GpsB; Provisional; Region: PRK14127 698737004151 DivIVA domain; Region: DivI1A_domain; TIGR03544 698737004152 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 698737004153 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737004154 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 698737004155 NADH(P)-binding; Region: NAD_binding_10; pfam13460 698737004156 putative NAD(P) binding site [chemical binding]; other site 698737004157 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 698737004158 Dynamin family; Region: Dynamin_N; pfam00350 698737004159 G1 box; other site 698737004160 GTP/Mg2+ binding site [chemical binding]; other site 698737004161 G2 box; other site 698737004162 Switch I region; other site 698737004163 G3 box; other site 698737004164 Switch II region; other site 698737004165 G4 box; other site 698737004166 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737004167 Dynamin family; Region: Dynamin_N; pfam00350 698737004168 G1 box; other site 698737004169 GTP/Mg2+ binding site [chemical binding]; other site 698737004170 G2 box; other site 698737004171 Switch I region; other site 698737004172 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737004173 G3 box; other site 698737004174 Switch II region; other site 698737004175 GTP/Mg2+ binding site [chemical binding]; other site 698737004176 G4 box; other site 698737004177 G5 box; other site 698737004178 5'-3' exonuclease; Region: 53EXOc; smart00475 698737004179 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 698737004180 active site 698737004181 metal binding site 1 [ion binding]; metal-binding site 698737004182 putative 5' ssDNA interaction site; other site 698737004183 metal binding site 3; metal-binding site 698737004184 metal binding site 2 [ion binding]; metal-binding site 698737004185 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 698737004186 putative DNA binding site [nucleotide binding]; other site 698737004187 putative metal binding site [ion binding]; other site 698737004188 anthranilate synthase component I; Provisional; Region: PRK13567 698737004189 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 698737004190 chorismate binding enzyme; Region: Chorismate_bind; cl10555 698737004191 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 698737004192 Glutamine amidotransferase class-I; Region: GATase; pfam00117 698737004193 glutamine binding [chemical binding]; other site 698737004194 catalytic triad [active] 698737004195 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 698737004196 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 698737004197 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 698737004198 active site 698737004199 ribulose/triose binding site [chemical binding]; other site 698737004200 phosphate binding site [ion binding]; other site 698737004201 substrate (anthranilate) binding pocket [chemical binding]; other site 698737004202 product (indole) binding pocket [chemical binding]; other site 698737004203 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 698737004204 active site 698737004205 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 698737004206 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 698737004207 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737004208 catalytic residue [active] 698737004209 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 698737004210 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 698737004211 substrate binding site [chemical binding]; other site 698737004212 active site 698737004213 catalytic residues [active] 698737004214 heterodimer interface [polypeptide binding]; other site 698737004215 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 698737004216 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 698737004217 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 698737004218 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698737004219 active site 698737004220 motif I; other site 698737004221 motif II; other site 698737004222 potential frameshift: common BLAST hit: gi|57866906|ref|YP_188527.1| transferrin receptor 698737004223 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698737004224 intersubunit interface [polypeptide binding]; other site 698737004225 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698737004226 oligoendopeptidase F; Region: pepF; TIGR00181 698737004227 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 698737004228 active site 698737004229 Zn binding site [ion binding]; other site 698737004230 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 698737004231 PhoU domain; Region: PhoU; pfam01895 698737004232 PhoU domain; Region: PhoU; pfam01895 698737004233 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 698737004234 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 698737004235 Walker A/P-loop; other site 698737004236 ATP binding site [chemical binding]; other site 698737004237 Q-loop/lid; other site 698737004238 ABC transporter signature motif; other site 698737004239 Walker B; other site 698737004240 D-loop; other site 698737004241 H-loop/switch region; other site 698737004242 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 698737004243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737004244 dimer interface [polypeptide binding]; other site 698737004245 conserved gate region; other site 698737004246 ABC-ATPase subunit interface; other site 698737004247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737004248 dimer interface [polypeptide binding]; other site 698737004249 conserved gate region; other site 698737004250 putative PBP binding loops; other site 698737004251 ABC-ATPase subunit interface; other site 698737004252 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698737004253 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 698737004254 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698737004255 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 698737004256 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737004257 Walker A/P-loop; other site 698737004258 ATP binding site [chemical binding]; other site 698737004259 Q-loop/lid; other site 698737004260 ABC transporter signature motif; other site 698737004261 Walker B; other site 698737004262 D-loop; other site 698737004263 H-loop/switch region; other site 698737004264 ABC transporter; Region: ABC_tran_2; pfam12848 698737004265 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 698737004266 aspartate kinase; Reviewed; Region: PRK06635 698737004267 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 698737004268 putative nucleotide binding site [chemical binding]; other site 698737004269 putative catalytic residues [active] 698737004270 putative Mg ion binding site [ion binding]; other site 698737004271 putative aspartate binding site [chemical binding]; other site 698737004272 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 698737004273 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 698737004274 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 698737004275 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737004276 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 698737004277 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 698737004278 dimer interface [polypeptide binding]; other site 698737004279 active site 698737004280 catalytic residue [active] 698737004281 dihydrodipicolinate reductase; Provisional; Region: PRK00048 698737004282 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737004283 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 698737004284 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 698737004285 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 698737004286 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 698737004287 active site 698737004288 trimer interface [polypeptide binding]; other site 698737004289 substrate binding site [chemical binding]; other site 698737004290 CoA binding site [chemical binding]; other site 698737004291 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698737004292 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 698737004293 metal binding site [ion binding]; metal-binding site 698737004294 dimer interface [polypeptide binding]; other site 698737004295 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 698737004296 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 698737004297 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698737004298 catalytic residue [active] 698737004299 diaminopimelate decarboxylase; Region: lysA; TIGR01048 698737004300 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 698737004301 active site 698737004302 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698737004303 substrate binding site [chemical binding]; other site 698737004304 catalytic residues [active] 698737004305 dimer interface [polypeptide binding]; other site 698737004306 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 698737004307 DNA-binding site [nucleotide binding]; DNA binding site 698737004308 RNA-binding motif; other site 698737004309 Protein of unknown function (DUF1033); Region: DUF1033; cl11549 698737004310 Acylphosphatase; Region: Acylphosphatase; cl00551 698737004311 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 698737004312 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 698737004313 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 698737004314 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 698737004315 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 698737004316 metal ion-dependent adhesion site (MIDAS); other site 698737004317 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698737004318 Walker A motif; other site 698737004319 ATP binding site [chemical binding]; other site 698737004320 Walker B motif; other site 698737004321 arginine finger; other site 698737004322 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 698737004323 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 698737004324 active site 698737004325 metal binding site [ion binding]; metal-binding site 698737004326 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 698737004327 active site 698737004328 metal binding site [ion binding]; metal-binding site 698737004329 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 698737004330 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698737004331 E3 interaction surface; other site 698737004332 lipoyl attachment site [posttranslational modification]; other site 698737004333 e3 binding domain; Region: E3_binding; pfam02817 698737004334 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 698737004335 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 698737004336 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 698737004337 TPP-binding site [chemical binding]; other site 698737004338 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 698737004339 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698737004340 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 698737004341 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698737004342 dimer interface [polypeptide binding]; other site 698737004343 phosphorylation site [posttranslational modification] 698737004344 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737004345 ATP binding site [chemical binding]; other site 698737004346 Mg2+ binding site [ion binding]; other site 698737004347 G-X-G motif; other site 698737004348 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698737004349 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698737004350 active site 698737004351 phosphorylation site [posttranslational modification] 698737004352 intermolecular recognition site; other site 698737004353 dimerization interface [polypeptide binding]; other site 698737004354 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698737004355 DNA binding site [nucleotide binding] 698737004356 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 698737004357 active site 698737004358 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 698737004359 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 698737004360 active site 698737004361 homodimer interface [polypeptide binding]; other site 698737004362 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 698737004363 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 698737004364 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 698737004365 C-terminal peptidase (prc); Region: prc; TIGR00225 698737004366 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 698737004367 protein binding site [polypeptide binding]; other site 698737004368 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 698737004369 Catalytic dyad [active] 698737004370 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 698737004371 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 698737004372 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 698737004373 HPr interaction site; other site 698737004374 glycerol kinase (GK) interaction site [polypeptide binding]; other site 698737004375 active site 698737004376 phosphorylation site [posttranslational modification] 698737004377 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 698737004378 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 698737004379 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 698737004380 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 698737004381 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 698737004382 folate binding site [chemical binding]; other site 698737004383 NADP+ binding site [chemical binding]; other site 698737004384 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 698737004385 dimerization interface [polypeptide binding]; other site 698737004386 active site 698737004387 Disulphide isomerase; Region: Disulph_isomer; pfam06491 698737004388 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 698737004389 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 698737004390 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 698737004391 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 698737004392 RNA/DNA hybrid binding site [nucleotide binding]; other site 698737004393 active site 698737004394 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 698737004395 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 698737004396 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 698737004397 P-loop; other site 698737004398 active site 698737004399 phosphorylation site [posttranslational modification] 698737004400 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 698737004401 active site 698737004402 phosphorylation site [posttranslational modification] 698737004403 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 698737004404 active site 698737004405 dimer interface [polypeptide binding]; other site 698737004406 magnesium binding site [ion binding]; other site 698737004407 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 698737004408 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 698737004409 AP (apurinic/apyrimidinic) site pocket; other site 698737004410 DNA interaction; other site 698737004411 Metal-binding active site; metal-binding site 698737004412 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 698737004413 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 698737004414 intersubunit interface [polypeptide binding]; other site 698737004415 active site 698737004416 Zn2+ binding site [ion binding]; other site 698737004417 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 698737004418 Helix-turn-helix domains; Region: HTH; cl00088 698737004419 PRD domain; Region: PRD; cl15445 698737004420 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 698737004421 P-loop; other site 698737004422 active site 698737004423 phosphorylation site [posttranslational modification] 698737004424 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 698737004425 prephenate dehydrogenase; Validated; Region: PRK06545 698737004426 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737004427 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 698737004428 DNA polymerase IV; Reviewed; Region: PRK03103 698737004429 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 698737004430 active site 698737004431 DNA binding site [nucleotide binding] 698737004432 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 698737004433 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 698737004434 active site 1 [active] 698737004435 dimer interface [polypeptide binding]; other site 698737004436 hexamer interface [polypeptide binding]; other site 698737004437 active site 2 [active] 698737004438 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 698737004439 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 698737004440 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698737004441 Predicted integral membrane protein [Function unknown]; Region: COG0392 698737004442 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 698737004443 Uncharacterized conserved protein [Function unknown]; Region: COG2898 698737004444 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 698737004445 Domain of unknown function DUF20; Region: UPF0118; pfam01594 698737004446 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 698737004447 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 698737004448 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 698737004449 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 698737004450 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 698737004451 CAP-like domain; other site 698737004452 active site 698737004453 primary dimer interface [polypeptide binding]; other site 698737004454 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698737004455 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 698737004456 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737004457 ATP binding site [chemical binding]; other site 698737004458 Mg2+ binding site [ion binding]; other site 698737004459 G-X-G motif; other site 698737004460 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 698737004461 anchoring element; other site 698737004462 dimer interface [polypeptide binding]; other site 698737004463 ATP binding site [chemical binding]; other site 698737004464 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 698737004465 active site 698737004466 putative metal-binding site [ion binding]; other site 698737004467 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 698737004468 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 698737004469 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 698737004470 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 698737004471 active site 698737004472 aconitate hydratase; Validated; Region: PRK09277 698737004473 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 698737004474 substrate binding site [chemical binding]; other site 698737004475 ligand binding site [chemical binding]; other site 698737004476 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 698737004477 substrate binding site [chemical binding]; other site 698737004478 BCCT family transporter; Region: BCCT; cl00569 698737004479 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 698737004480 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 698737004481 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 698737004482 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 698737004483 Walker A/P-loop; other site 698737004484 ATP binding site [chemical binding]; other site 698737004485 Q-loop/lid; other site 698737004486 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 698737004487 ABC transporter signature motif; other site 698737004488 Walker B; other site 698737004489 D-loop; other site 698737004490 H-loop/switch region; other site 698737004491 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 698737004492 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 698737004493 active site 698737004494 metal binding site [ion binding]; metal-binding site 698737004495 DNA binding site [nucleotide binding] 698737004496 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 698737004497 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 698737004498 Uncharacterized protein family (UPF0154); Region: UPF0154; cl01536 698737004499 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 698737004500 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 698737004501 TPP-binding site [chemical binding]; other site 698737004502 dimer interface [polypeptide binding]; other site 698737004503 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 698737004504 PYR/PP interface [polypeptide binding]; other site 698737004505 dimer interface [polypeptide binding]; other site 698737004506 TPP binding site [chemical binding]; other site 698737004507 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698737004508 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 698737004509 LexA repressor; Validated; Region: PRK00215 698737004510 Helix-turn-helix domains; Region: HTH; cl00088 698737004511 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 698737004512 Catalytic site [active] 698737004513 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 698737004514 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 698737004515 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 698737004516 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 698737004517 active site 698737004518 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 698737004519 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 698737004520 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 698737004521 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 698737004522 tetramer interface [polypeptide binding]; other site 698737004523 heme binding pocket [chemical binding]; other site 698737004524 NADPH binding site [chemical binding]; other site 698737004525 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 698737004526 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698737004527 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698737004528 active site 698737004529 motif I; other site 698737004530 motif II; other site 698737004531 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 698737004532 homoserine kinase; Provisional; Region: PRK01212 698737004533 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 698737004534 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 698737004535 threonine synthase; Reviewed; Region: PRK06721 698737004536 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 698737004537 homodimer interface [polypeptide binding]; other site 698737004538 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737004539 catalytic residue [active] 698737004540 homoserine dehydrogenase; Provisional; Region: PRK06349 698737004541 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737004542 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 698737004543 aspartate kinase; Reviewed; Region: PRK09034 698737004544 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 698737004545 putative catalytic residues [active] 698737004546 putative nucleotide binding site [chemical binding]; other site 698737004547 putative aspartate binding site [chemical binding]; other site 698737004548 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 698737004549 allosteric regulatory residue; other site 698737004550 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 698737004551 Staphylococcal nuclease homologues; Region: SNc; smart00318 698737004552 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 698737004553 Catalytic site; other site 698737004554 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698737004555 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698737004556 active site 698737004557 phosphorylation site [posttranslational modification] 698737004558 intermolecular recognition site; other site 698737004559 dimerization interface [polypeptide binding]; other site 698737004560 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698737004561 DNA binding residues [nucleotide binding] 698737004562 dimerization interface [polypeptide binding]; other site 698737004563 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698737004564 Histidine kinase; Region: HisKA_3; pfam07730 698737004565 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 698737004566 ABC-2 type transporter; Region: ABC2_membrane; cl11417 698737004567 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698737004568 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 698737004569 Walker A/P-loop; other site 698737004570 ATP binding site [chemical binding]; other site 698737004571 Q-loop/lid; other site 698737004572 ABC transporter signature motif; other site 698737004573 Walker B; other site 698737004574 D-loop; other site 698737004575 H-loop/switch region; other site 698737004576 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 698737004577 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 698737004578 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 698737004579 putative active site [active] 698737004580 catalytic site [active] 698737004581 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 698737004582 putative active site [active] 698737004583 catalytic site [active] 698737004584 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 698737004585 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698737004586 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698737004587 catalytic residue [active] 698737004588 glutamine synthetase, type I; Region: GlnA; TIGR00653 698737004589 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 698737004590 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698737004591 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 698737004592 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698737004593 DNA binding residues [nucleotide binding] 698737004594 putative dimer interface [polypeptide binding]; other site 698737004595 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 698737004596 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698737004597 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 698737004598 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 698737004599 HflX GTPase family; Region: HflX; cd01878 698737004600 G1 box; other site 698737004601 GTP/Mg2+ binding site [chemical binding]; other site 698737004602 Switch I region; other site 698737004603 G2 box; other site 698737004604 G3 box; other site 698737004605 Switch II region; other site 698737004606 G4 box; other site 698737004607 G5 box; other site 698737004608 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 698737004609 catalytic residues [active] 698737004610 dimer interface [polypeptide binding]; other site 698737004611 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 698737004612 Sm1 motif; other site 698737004613 D3 - B interaction site; other site 698737004614 D1 - D2 interaction site; other site 698737004615 Hfq - Hfq interaction site; other site 698737004616 RNA binding pocket [nucleotide binding]; other site 698737004617 Sm2 motif; other site 698737004618 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737004619 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 698737004620 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 698737004621 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 698737004622 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 698737004623 glycerol kinase; Provisional; Region: glpK; PRK00047 698737004624 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 698737004625 N- and C-terminal domain interface [polypeptide binding]; other site 698737004626 active site 698737004627 MgATP binding site [chemical binding]; other site 698737004628 catalytic site [active] 698737004629 metal binding site [ion binding]; metal-binding site 698737004630 glycerol binding site [chemical binding]; other site 698737004631 homotetramer interface [polypeptide binding]; other site 698737004632 homodimer interface [polypeptide binding]; other site 698737004633 FBP binding site [chemical binding]; other site 698737004634 protein IIAGlc interface [polypeptide binding]; other site 698737004635 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 698737004636 amphipathic channel; other site 698737004637 Asn-Pro-Ala signature motifs; other site 698737004638 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 698737004639 Asn-Pro-Ala signature motifs; other site 698737004640 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 698737004641 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 698737004642 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737004643 ATP binding site [chemical binding]; other site 698737004644 Mg2+ binding site [ion binding]; other site 698737004645 G-X-G motif; other site 698737004646 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 698737004647 ATP binding site [chemical binding]; other site 698737004648 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 698737004649 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 698737004650 MutS domain I; Region: MutS_I; pfam01624 698737004651 MutS domain II; Region: MutS_II; pfam05188 698737004652 MutS family domain IV; Region: MutS_IV; pfam05190 698737004653 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 698737004654 Walker A/P-loop; other site 698737004655 ATP binding site [chemical binding]; other site 698737004656 Q-loop/lid; other site 698737004657 ABC transporter signature motif; other site 698737004658 Walker B; other site 698737004659 D-loop; other site 698737004660 H-loop/switch region; other site 698737004661 Thiamine-precursor transporter protein (ThiW); Region: ThiW; cl01952 698737004662 Protein of unknown function (DUF964); Region: DUF964; cl01483 698737004663 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 698737004664 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 698737004665 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698737004666 FeS/SAM binding site; other site 698737004667 TRAM domain; Region: TRAM; cl01282 698737004668 Domain of unknown function DUF77; Region: DUF77; cl00307 698737004669 Protein of unknown function (DUF867); Region: DUF867; cl01713 698737004670 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 698737004671 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 698737004672 TPP-binding site [chemical binding]; other site 698737004673 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 698737004674 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 698737004675 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 698737004676 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 698737004677 dimer interface [polypeptide binding]; other site 698737004678 PYR/PP interface [polypeptide binding]; other site 698737004679 TPP binding site [chemical binding]; other site 698737004680 substrate binding site [chemical binding]; other site 698737004681 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 698737004682 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698737004683 putative active site [active] 698737004684 metal binding site [ion binding]; metal-binding site 698737004685 homodimer binding site [polypeptide binding]; other site 698737004686 phosphodiesterase; Provisional; Region: PRK12704 698737004687 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 698737004688 recombinase A; Provisional; Region: recA; PRK09354 698737004689 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 698737004690 hexamer interface [polypeptide binding]; other site 698737004691 Walker A motif; other site 698737004692 ATP binding site [chemical binding]; other site 698737004693 Walker B motif; other site 698737004694 competence damage-inducible protein A; Provisional; Region: PRK00549 698737004695 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 698737004696 putative MPT binding site; other site 698737004697 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 698737004698 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698737004699 non-specific DNA binding site [nucleotide binding]; other site 698737004700 salt bridge; other site 698737004701 sequence-specific DNA binding site [nucleotide binding]; other site 698737004702 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 698737004703 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 698737004704 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 698737004705 classical (c) SDRs; Region: SDR_c; cd05233 698737004706 NAD(P) binding site [chemical binding]; other site 698737004707 active site 698737004708 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 698737004709 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 698737004710 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 698737004711 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 698737004712 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 698737004713 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 698737004714 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698737004715 DNA-binding site [nucleotide binding]; DNA binding site 698737004716 UTRA domain; Region: UTRA; cl01230 698737004717 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737004718 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 698737004719 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 698737004720 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 698737004721 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 698737004722 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 698737004723 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 698737004724 RNase E interface [polypeptide binding]; other site 698737004725 trimer interface [polypeptide binding]; other site 698737004726 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 698737004727 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 698737004728 RNase E interface [polypeptide binding]; other site 698737004729 trimer interface [polypeptide binding]; other site 698737004730 active site 698737004731 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 698737004732 putative nucleic acid binding region [nucleotide binding]; other site 698737004733 G-X-X-G motif; other site 698737004734 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 698737004735 RNA binding site [nucleotide binding]; other site 698737004736 domain interface; other site 698737004737 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 698737004738 16S/18S rRNA binding site [nucleotide binding]; other site 698737004739 S13e-L30e interaction site [polypeptide binding]; other site 698737004740 25S rRNA binding site [nucleotide binding]; other site 698737004741 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 698737004742 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 698737004743 active site 698737004744 Riboflavin kinase; Region: Flavokinase; cl03312 698737004745 tRNA pseudouridine synthase B; Provisional; Region: PRK14123 698737004746 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 698737004747 RNA binding site [nucleotide binding]; other site 698737004748 active site 698737004749 Ribosome-binding factor A; Region: RBFA; cl00542 698737004750 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698737004751 translation initiation factor IF-2; Region: IF-2; TIGR00487 698737004752 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698737004753 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 698737004754 G1 box; other site 698737004755 putative GEF interaction site [polypeptide binding]; other site 698737004756 GTP/Mg2+ binding site [chemical binding]; other site 698737004757 Switch I region; other site 698737004758 G2 box; other site 698737004759 G3 box; other site 698737004760 Switch II region; other site 698737004761 G4 box; other site 698737004762 G5 box; other site 698737004763 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 698737004764 Translation-initiation factor 2; Region: IF-2; pfam11987 698737004765 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 698737004766 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 698737004767 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 698737004768 putative RNA binding cleft [nucleotide binding]; other site 698737004769 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 698737004770 NusA N-terminal domain; Region: NusA_N; pfam08529 698737004771 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 698737004772 RNA binding site [nucleotide binding]; other site 698737004773 homodimer interface [polypeptide binding]; other site 698737004774 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 698737004775 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 698737004776 G-X-X-G motif; other site 698737004777 ribosome maturation protein RimP; Reviewed; Region: PRK00092 698737004778 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 698737004779 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 698737004780 Sm1 motif; other site 698737004781 predicted subunit interaction site [polypeptide binding]; other site 698737004782 RNA binding pocket [nucleotide binding]; other site 698737004783 Sm2 motif; other site 698737004784 DNA polymerase III PolC; Validated; Region: polC; PRK00448 698737004785 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 698737004786 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 698737004787 generic binding surface II; other site 698737004788 generic binding surface I; other site 698737004789 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 698737004790 active site 698737004791 substrate binding site [chemical binding]; other site 698737004792 catalytic site [active] 698737004793 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 698737004794 prolyl-tRNA synthetase; Provisional; Region: PRK09194 698737004795 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 698737004796 dimer interface [polypeptide binding]; other site 698737004797 motif 1; other site 698737004798 active site 698737004799 motif 2; other site 698737004800 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 698737004801 putative deacylase active site [active] 698737004802 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 698737004803 active site 698737004804 motif 3; other site 698737004805 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 698737004806 anticodon binding site; other site 698737004807 RIP metalloprotease RseP; Region: TIGR00054 698737004808 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 698737004809 active site 698737004810 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 698737004811 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 698737004812 protein binding site [polypeptide binding]; other site 698737004813 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 698737004814 putative substrate binding region [chemical binding]; other site 698737004815 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 698737004816 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 698737004817 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 698737004818 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 698737004819 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 698737004820 catalytic residue [active] 698737004821 putative FPP diphosphate binding site; other site 698737004822 putative FPP binding hydrophobic cleft; other site 698737004823 dimer interface [polypeptide binding]; other site 698737004824 putative IPP diphosphate binding site; other site 698737004825 ribosome recycling factor; Reviewed; Region: frr; PRK00083 698737004826 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 698737004827 hinge region; other site 698737004828 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 698737004829 putative nucleotide binding site [chemical binding]; other site 698737004830 uridine monophosphate binding site [chemical binding]; other site 698737004831 homohexameric interface [polypeptide binding]; other site 698737004832 elongation factor Ts; Provisional; Region: tsf; PRK09377 698737004833 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 698737004834 Elongation factor TS; Region: EF_TS; pfam00889 698737004835 Elongation factor TS; Region: EF_TS; pfam00889 698737004836 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 698737004837 rRNA interaction site [nucleotide binding]; other site 698737004838 S8 interaction site; other site 698737004839 putative laminin-1 binding site; other site 698737004840 transcriptional repressor CodY; Validated; Region: PRK04158 698737004841 CodY GAF-like domain; Region: CodY; pfam06018 698737004842 Helix-turn-helix domains; Region: HTH; cl00088 698737004843 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 698737004844 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698737004845 Walker A motif; other site 698737004846 ATP binding site [chemical binding]; other site 698737004847 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737004848 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 698737004849 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 698737004850 active site 698737004851 HslU subunit interaction site [polypeptide binding]; other site 698737004852 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 698737004853 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698737004854 DNA binding site [nucleotide binding] 698737004855 Int/Topo IB signature motif; other site 698737004856 active site 698737004857 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 698737004858 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737004859 DNA topoisomerase I; Validated; Region: PRK05582 698737004860 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 698737004861 active site 698737004862 interdomain interaction site; other site 698737004863 putative metal-binding site [ion binding]; other site 698737004864 nucleotide binding site [chemical binding]; other site 698737004865 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 698737004866 domain I; other site 698737004867 DNA binding groove [nucleotide binding] 698737004868 phosphate binding site [ion binding]; other site 698737004869 domain II; other site 698737004870 domain III; other site 698737004871 nucleotide binding site [chemical binding]; other site 698737004872 catalytic site [active] 698737004873 domain IV; other site 698737004874 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 698737004875 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 698737004876 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 698737004877 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 698737004878 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 698737004879 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 698737004880 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 698737004881 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 698737004882 putative peptidoglycan binding site; other site 698737004883 NlpC/P60 family; Region: NLPC_P60; cl11438 698737004884 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 698737004885 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737004886 CoA-ligase; Region: Ligase_CoA; cl02894 698737004887 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 698737004888 ATP-grasp domain; Region: ATP-grasp_4; cl03087 698737004889 CoA-ligase; Region: Ligase_CoA; cl02894 698737004890 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 698737004891 RNA/DNA hybrid binding site [nucleotide binding]; other site 698737004892 active site 698737004893 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 698737004894 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 698737004895 GTP/Mg2+ binding site [chemical binding]; other site 698737004896 G4 box; other site 698737004897 G5 box; other site 698737004898 G1 box; other site 698737004899 Switch I region; other site 698737004900 G2 box; other site 698737004901 G3 box; other site 698737004902 Switch II region; other site 698737004903 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 698737004904 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 698737004905 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 698737004906 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 698737004907 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 698737004908 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 698737004909 RimM N-terminal domain; Region: RimM; pfam01782 698737004910 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 698737004911 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 698737004912 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 698737004913 beta-lactamase TEM; Provisional; Region: PRK15442 698737004914 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 698737004915 BlaR1 peptidase M56; Region: Peptidase_M56; cl15829 698737004916 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 698737004917 Helix-turn-helix domains; Region: HTH; cl00088 698737004918 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 698737004919 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 698737004920 catalytic residues [active] 698737004921 catalytic nucleophile [active] 698737004922 Presynaptic Site I dimer interface [polypeptide binding]; other site 698737004923 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 698737004924 Synaptic Flat tetramer interface [polypeptide binding]; other site 698737004925 Synaptic Site I dimer interface [polypeptide binding]; other site 698737004926 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 698737004927 DNA-binding interface [nucleotide binding]; DNA binding site 698737004928 Helix-turn-helix domains; Region: HTH; cl00088 698737004929 Integrase core domain; Region: rve; cl01316 698737004930 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 698737004931 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 698737004932 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 698737004933 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 698737004934 dimer interface [polypeptide binding]; other site 698737004935 active site 698737004936 acyl-CoA synthetase; Validated; Region: PRK07638 698737004937 AMP-binding enzyme; Region: AMP-binding; cl15778 698737004938 signal recognition particle protein; Provisional; Region: PRK10867 698737004939 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 698737004940 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 698737004941 P loop; other site 698737004942 GTP binding site [chemical binding]; other site 698737004943 Signal peptide binding domain; Region: SRP_SPB; pfam02978 698737004944 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 698737004945 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 698737004946 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 698737004947 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 698737004948 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 698737004949 P loop; other site 698737004950 GTP binding site [chemical binding]; other site 698737004951 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 698737004952 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 698737004953 Walker A/P-loop; other site 698737004954 ATP binding site [chemical binding]; other site 698737004955 Q-loop/lid; other site 698737004956 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 698737004957 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 698737004958 ABC transporter signature motif; other site 698737004959 Walker B; other site 698737004960 D-loop; other site 698737004961 H-loop/switch region; other site 698737004962 ribonuclease III; Reviewed; Region: rnc; PRK00102 698737004963 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 698737004964 dimerization interface [polypeptide binding]; other site 698737004965 active site 698737004966 metal binding site [ion binding]; metal-binding site 698737004967 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 698737004968 dsRNA binding site [nucleotide binding]; other site 698737004969 Phosphopantetheine attachment site; Region: PP-binding; cl09936 698737004970 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 698737004971 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 698737004972 NAD(P) binding site [chemical binding]; other site 698737004973 homotetramer interface [polypeptide binding]; other site 698737004974 homodimer interface [polypeptide binding]; other site 698737004975 active site 698737004976 Acyl transferase domain; Region: Acyl_transf_1; cl08282 698737004977 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 698737004978 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 698737004979 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 698737004980 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 698737004981 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 698737004982 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 698737004983 generic binding surface II; other site 698737004984 ssDNA binding site; other site 698737004985 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698737004986 ATP binding site [chemical binding]; other site 698737004987 putative Mg++ binding site [ion binding]; other site 698737004988 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698737004989 nucleotide binding region [chemical binding]; other site 698737004990 ATP-binding site [chemical binding]; other site 698737004991 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 698737004992 DAK2 domain; Region: Dak2; cl03685 698737004993 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 698737004994 Asp23 family; Region: Asp23; cl00574 698737004995 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 698737004996 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 698737004997 Thiamine pyrophosphokinase; Region: TPK; cd07995 698737004998 active site 698737004999 dimerization interface [polypeptide binding]; other site 698737005000 thiamine binding site [chemical binding]; other site 698737005001 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 698737005002 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 698737005003 substrate binding site [chemical binding]; other site 698737005004 hexamer interface [polypeptide binding]; other site 698737005005 metal binding site [ion binding]; metal-binding site 698737005006 GTPase RsgA; Reviewed; Region: PRK00098 698737005007 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 698737005008 RNA binding site [nucleotide binding]; other site 698737005009 homodimer interface [polypeptide binding]; other site 698737005010 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 698737005011 GTPase/Zn-binding domain interface [polypeptide binding]; other site 698737005012 GTP/Mg2+ binding site [chemical binding]; other site 698737005013 G4 box; other site 698737005014 G5 box; other site 698737005015 G1 box; other site 698737005016 Switch I region; other site 698737005017 G2 box; other site 698737005018 G3 box; other site 698737005019 Switch II region; other site 698737005020 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 698737005021 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698737005022 active site 698737005023 ATP binding site [chemical binding]; other site 698737005024 substrate binding site [chemical binding]; other site 698737005025 activation loop (A-loop); other site 698737005026 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 698737005027 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698737005028 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698737005029 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698737005030 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 698737005031 Protein phosphatase 2C; Region: PP2C; pfam00481 698737005032 active site 698737005033 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 698737005034 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698737005035 FeS/SAM binding site; other site 698737005036 16S rRNA methyltransferase B; Provisional; Region: PRK14902 698737005037 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 698737005038 putative RNA binding site [nucleotide binding]; other site 698737005039 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 698737005040 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 698737005041 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 698737005042 putative active site [active] 698737005043 substrate binding site [chemical binding]; other site 698737005044 putative cosubstrate binding site; other site 698737005045 catalytic site [active] 698737005046 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 698737005047 substrate binding site [chemical binding]; other site 698737005048 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 698737005049 active site 698737005050 catalytic residues [active] 698737005051 metal binding site [ion binding]; metal-binding site 698737005052 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 698737005053 primosome assembly protein PriA; Validated; Region: PRK05580 698737005054 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698737005055 ATP binding site [chemical binding]; other site 698737005056 putative Mg++ binding site [ion binding]; other site 698737005057 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737005058 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 698737005059 Flavoprotein; Region: Flavoprotein; cl08021 698737005060 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 698737005061 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 698737005062 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 698737005063 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 698737005064 catalytic site [active] 698737005065 G-X2-G-X-G-K; other site 698737005066 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 698737005067 Domain of unknown function (DUF814); Region: DUF814; pfam05670 698737005068 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 698737005069 dimer interface [polypeptide binding]; other site 698737005070 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 698737005071 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698737005072 active site 698737005073 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 698737005074 active site 698737005075 dimer interface [polypeptide binding]; other site 698737005076 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 698737005077 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698737005078 ATP-grasp domain; Region: ATP-grasp_4; cl03087 698737005079 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 698737005080 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698737005081 ATP-grasp domain; Region: ATP-grasp_4; cl03087 698737005082 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 698737005083 IMP binding site; other site 698737005084 dimer interface [polypeptide binding]; other site 698737005085 interdomain contacts; other site 698737005086 partial ornithine binding site; other site 698737005087 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 698737005088 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 698737005089 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 698737005090 catalytic site [active] 698737005091 subunit interface [polypeptide binding]; other site 698737005092 dihydroorotase; Validated; Region: pyrC; PRK09357 698737005093 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698737005094 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 698737005095 active site 698737005096 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 698737005097 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 698737005098 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737005099 uracil transporter; Provisional; Region: PRK10720 698737005100 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 698737005101 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 698737005102 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698737005103 active site 698737005104 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 698737005105 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698737005106 RNA binding surface [nucleotide binding]; other site 698737005107 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 698737005108 active site 698737005109 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 698737005110 lipoprotein signal peptidase; Provisional; Region: PRK14787 698737005111 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 698737005112 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 698737005113 active site 698737005114 metal binding site [ion binding]; metal-binding site 698737005115 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 698737005116 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 698737005117 HIGH motif; other site 698737005118 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 698737005119 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 698737005120 active site 698737005121 KMSKS motif; other site 698737005122 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 698737005123 tRNA binding surface [nucleotide binding]; other site 698737005124 anticodon binding site; other site 698737005125 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 698737005126 DivIVA protein; Region: DivIVA; pfam05103 698737005127 DivIVA domain; Region: DivI1A_domain; TIGR03544 698737005128 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 698737005129 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698737005130 RNA binding surface [nucleotide binding]; other site 698737005131 YGGT family; Region: YGGT; cl00508 698737005132 Protein of unknown function (DUF552); Region: DUF552; cl00775 698737005133 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 698737005134 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698737005135 catalytic residue [active] 698737005136 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 698737005137 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 698737005138 cell division protein FtsZ; Validated; Region: PRK09330 698737005139 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 698737005140 nucleotide binding site [chemical binding]; other site 698737005141 SulA interaction site; other site 698737005142 cell division protein FtsA; Region: ftsA; TIGR01174 698737005143 Cell division protein FtsA; Region: FtsA; cl11496 698737005144 Cell division protein FtsA; Region: FtsA; cl11496 698737005145 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 698737005146 Cell division protein FtsQ; Region: FtsQ; pfam03799 698737005147 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 698737005148 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737005149 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698737005150 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698737005151 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 698737005152 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 698737005153 Mg++ binding site [ion binding]; other site 698737005154 putative catalytic motif [active] 698737005155 putative substrate binding site [chemical binding]; other site 698737005156 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 698737005157 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 698737005158 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 698737005159 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 698737005160 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 698737005161 Septum formation initiator; Region: DivIC; cl11433 698737005162 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 698737005163 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737005164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 698737005165 MraZ protein; Region: MraZ; pfam02381 698737005166 MraZ protein; Region: MraZ; pfam02381 698737005167 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 698737005168 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 698737005169 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 698737005170 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 698737005171 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698737005172 motif II; other site 698737005173 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 698737005174 active site 698737005175 metal binding site [ion binding]; metal-binding site 698737005176 homotetramer interface [polypeptide binding]; other site 698737005177 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 698737005178 active site 698737005179 dimerization interface [polypeptide binding]; other site 698737005180 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 698737005181 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 698737005182 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 698737005183 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 698737005184 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737005185 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 698737005186 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 698737005187 putative Iron-sulfur protein interface [polypeptide binding]; other site 698737005188 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 698737005189 proximal heme binding site [chemical binding]; other site 698737005190 distal heme binding site [chemical binding]; other site 698737005191 putative dimer interface [polypeptide binding]; other site 698737005192 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 698737005193 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 698737005194 GIY-YIG motif/motif A; other site 698737005195 active site 698737005196 catalytic site [active] 698737005197 putative DNA binding site [nucleotide binding]; other site 698737005198 metal binding site [ion binding]; metal-binding site 698737005199 UvrB/uvrC motif; Region: UVR; pfam02151 698737005200 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 698737005201 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698737005202 catalytic residues [active] 698737005203 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 698737005204 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 698737005205 Walker A/P-loop; other site 698737005206 ATP binding site [chemical binding]; other site 698737005207 Q-loop/lid; other site 698737005208 ABC transporter signature motif; other site 698737005209 Walker B; other site 698737005210 D-loop; other site 698737005211 H-loop/switch region; other site 698737005212 Smr domain; Region: Smr; cl02619 698737005213 hypothetical protein; Provisional; Region: PRK08609 698737005214 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 698737005215 active site 698737005216 primer binding site [nucleotide binding]; other site 698737005217 NTP binding site [chemical binding]; other site 698737005218 metal binding triad [ion binding]; metal-binding site 698737005219 Colicin V production protein; Region: Colicin_V; cl00567 698737005220 Cell division protein ZapA; Region: ZapA; cl01146 698737005221 ribonuclease HIII; Provisional; Region: PRK00996 698737005222 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 698737005223 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 698737005224 RNA/DNA hybrid binding site [nucleotide binding]; other site 698737005225 active site 698737005226 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 698737005227 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 698737005228 putative tRNA-binding site [nucleotide binding]; other site 698737005229 B3/4 domain; Region: B3_4; cl11458 698737005230 tRNA synthetase B5 domain; Region: B5; cl08394 698737005231 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 698737005232 dimer interface [polypeptide binding]; other site 698737005233 motif 1; other site 698737005234 motif 3; other site 698737005235 motif 2; other site 698737005236 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 698737005237 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 698737005238 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 698737005239 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 698737005240 dimer interface [polypeptide binding]; other site 698737005241 motif 1; other site 698737005242 active site 698737005243 motif 2; other site 698737005244 motif 3; other site 698737005245 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698737005246 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 698737005247 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 698737005248 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 698737005249 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 698737005250 hypothetical protein; Provisional; Region: PRK13670 698737005251 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698737005252 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 698737005253 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 698737005254 active site 698737005255 (T/H)XGH motif; other site 698737005256 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698737005257 S-adenosylmethionine binding site [chemical binding]; other site 698737005258 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 698737005259 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 698737005260 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 698737005261 putative active site [active] 698737005262 catalytic site [active] 698737005263 putative metal binding site [ion binding]; other site 698737005264 Protein of unknown function (DUF964); Region: DUF964; cl01483 698737005265 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 698737005266 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 698737005267 Protein of unknown function (DUF420); Region: DUF420; cl00989 698737005268 UbiA prenyltransferase family; Region: UbiA; cl00337 698737005269 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 698737005270 pyruvate carboxylase; Reviewed; Region: PRK12999 698737005271 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698737005272 ATP-grasp domain; Region: ATP-grasp_4; cl03087 698737005273 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 698737005274 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 698737005275 active site 698737005276 catalytic residues [active] 698737005277 metal binding site [ion binding]; metal-binding site 698737005278 homodimer binding site [polypeptide binding]; other site 698737005279 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698737005280 carboxyltransferase (CT) interaction site; other site 698737005281 biotinylation site [posttranslational modification]; other site 698737005282 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 698737005283 Protein of unknown function (DUF1507); Region: DUF1507; cl11487 698737005284 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; cl11558 698737005285 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 698737005286 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 698737005287 G1 box; other site 698737005288 putative GEF interaction site [polypeptide binding]; other site 698737005289 GTP/Mg2+ binding site [chemical binding]; other site 698737005290 Switch I region; other site 698737005291 G2 box; other site 698737005292 G3 box; other site 698737005293 Switch II region; other site 698737005294 G4 box; other site 698737005295 G5 box; other site 698737005296 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 698737005297 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 698737005298 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 698737005299 active site 698737005300 Protein of unknown function (DUF1054); Region: DUF1054; cl11544 698737005301 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 698737005302 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 698737005303 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 698737005304 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 698737005305 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 698737005306 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698737005307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737005308 dimer interface [polypeptide binding]; other site 698737005309 conserved gate region; other site 698737005310 putative PBP binding loops; other site 698737005311 ABC-ATPase subunit interface; other site 698737005312 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737005313 dimer interface [polypeptide binding]; other site 698737005314 conserved gate region; other site 698737005315 putative PBP binding loops; other site 698737005316 ABC-ATPase subunit interface; other site 698737005317 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698737005318 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737005319 Walker A/P-loop; other site 698737005320 ATP binding site [chemical binding]; other site 698737005321 Q-loop/lid; other site 698737005322 ABC transporter signature motif; other site 698737005323 Walker B; other site 698737005324 D-loop; other site 698737005325 H-loop/switch region; other site 698737005326 TOBE domain; Region: TOBE_2; cl01440 698737005327 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698737005328 sequence-specific DNA binding site [nucleotide binding]; other site 698737005329 salt bridge; other site 698737005330 Cupin domain; Region: Cupin_2; cl09118 698737005331 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 698737005332 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 698737005333 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737005334 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698737005335 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698737005336 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 698737005337 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698737005338 E3 interaction surface; other site 698737005339 lipoyl attachment site [posttranslational modification]; other site 698737005340 e3 binding domain; Region: E3_binding; pfam02817 698737005341 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 698737005342 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 698737005343 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 698737005344 alpha subunit interface [polypeptide binding]; other site 698737005345 TPP binding site [chemical binding]; other site 698737005346 heterodimer interface [polypeptide binding]; other site 698737005347 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698737005348 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 698737005349 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 698737005350 TPP-binding site [chemical binding]; other site 698737005351 tetramer interface [polypeptide binding]; other site 698737005352 heterodimer interface [polypeptide binding]; other site 698737005353 phosphorylation loop region [posttranslational modification] 698737005354 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 698737005355 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 698737005356 active site 698737005357 catalytic residues [active] 698737005358 metal binding site [ion binding]; metal-binding site 698737005359 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 698737005360 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 698737005361 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 698737005362 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 698737005363 Transposase domain (DUF772); Region: DUF772; cl15789 698737005364 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 698737005365 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737005366 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 698737005367 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 698737005368 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 698737005369 catalytic residues [active] 698737005370 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 698737005371 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 698737005372 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 698737005373 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 698737005374 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 698737005375 dimerization domain swap beta strand [polypeptide binding]; other site 698737005376 regulatory protein interface [polypeptide binding]; other site 698737005377 active site 698737005378 regulatory phosphorylation site [posttranslational modification]; other site 698737005379 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 698737005380 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 698737005381 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 698737005382 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698737005383 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 698737005384 Walker A/P-loop; other site 698737005385 ATP binding site [chemical binding]; other site 698737005386 Q-loop/lid; other site 698737005387 ABC transporter signature motif; other site 698737005388 Walker B; other site 698737005389 D-loop; other site 698737005390 H-loop/switch region; other site 698737005391 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 698737005392 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698737005393 Walker A/P-loop; other site 698737005394 ATP binding site [chemical binding]; other site 698737005395 Q-loop/lid; other site 698737005396 ABC transporter signature motif; other site 698737005397 Walker B; other site 698737005398 D-loop; other site 698737005399 H-loop/switch region; other site 698737005400 Cobalt transport protein; Region: CbiQ; cl00463 698737005401 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 698737005402 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790 698737005403 ATP-grasp domain; Region: ATP-grasp_4; cl03087 698737005404 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 698737005405 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 698737005406 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 698737005407 purine monophosphate binding site [chemical binding]; other site 698737005408 dimer interface [polypeptide binding]; other site 698737005409 putative catalytic residues [active] 698737005410 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 698737005411 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 698737005412 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 698737005413 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 698737005414 active site 698737005415 substrate binding site [chemical binding]; other site 698737005416 cosubstrate binding site; other site 698737005417 catalytic site [active] 698737005418 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 698737005419 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 698737005420 dimerization interface [polypeptide binding]; other site 698737005421 putative ATP binding site [chemical binding]; other site 698737005422 amidophosphoribosyltransferase; Provisional; Region: PRK07272 698737005423 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 698737005424 active site 698737005425 tetramer interface [polypeptide binding]; other site 698737005426 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698737005427 active site 698737005428 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 698737005429 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 698737005430 dimerization interface [polypeptide binding]; other site 698737005431 ATP binding site [chemical binding]; other site 698737005432 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 698737005433 dimerization interface [polypeptide binding]; other site 698737005434 ATP binding site [chemical binding]; other site 698737005435 Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118 698737005436 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 698737005437 putative active site [active] 698737005438 catalytic triad [active] 698737005439 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 698737005440 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 698737005441 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 698737005442 ATP binding site [chemical binding]; other site 698737005443 active site 698737005444 substrate binding site [chemical binding]; other site 698737005445 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737005446 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 698737005447 ATP-grasp domain; Region: ATP-grasp_4; cl03087 698737005448 AIR carboxylase; Region: AIRC; cl00310 698737005449 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175 698737005450 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 698737005451 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 698737005452 homodimer interface [polypeptide binding]; other site 698737005453 NADP binding site [chemical binding]; other site 698737005454 substrate binding site [chemical binding]; other site 698737005455 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 698737005456 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 698737005457 heme-binding site [chemical binding]; other site 698737005458 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 698737005459 FAD binding pocket [chemical binding]; other site 698737005460 conserved FAD binding motif [chemical binding]; other site 698737005461 phosphate binding motif [ion binding]; other site 698737005462 beta-alpha-beta structure motif; other site 698737005463 NAD binding pocket [chemical binding]; other site 698737005464 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 698737005465 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 698737005466 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 698737005467 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 698737005468 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 698737005469 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 698737005470 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 698737005471 D-pathway; other site 698737005472 Putative ubiquinol binding site [chemical binding]; other site 698737005473 Low-spin heme (heme b) binding site [chemical binding]; other site 698737005474 Putative water exit pathway; other site 698737005475 Binuclear center (heme o3/CuB) [ion binding]; other site 698737005476 K-pathway; other site 698737005477 Putative proton exit pathway; other site 698737005478 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 698737005479 Subunit I/III interface [polypeptide binding]; other site 698737005480 Subunit III/IV interface [polypeptide binding]; other site 698737005481 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 698737005482 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 698737005483 active site 698737005484 tetramer interface [polypeptide binding]; other site 698737005485 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 698737005486 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 698737005487 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 698737005488 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 698737005489 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698737005490 Coenzyme A binding pocket [chemical binding]; other site 698737005491 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 698737005492 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 698737005493 amidase catalytic site [active] 698737005494 Zn binding residues [ion binding]; other site 698737005495 substrate binding site [chemical binding]; other site 698737005496 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 698737005497 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698737005498 Helix-turn-helix domains; Region: HTH; cl00088 698737005499 OpgC protein; Region: OpgC_C; cl00792 698737005500 Acyltransferase family; Region: Acyl_transf_3; pfam01757 698737005501 aminotransferase A; Validated; Region: PRK07683 698737005502 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698737005503 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737005504 homodimer interface [polypeptide binding]; other site 698737005505 catalytic residue [active] 698737005506 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698737005507 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 698737005508 substrate binding site [chemical binding]; other site 698737005509 oxyanion hole (OAH) forming residues; other site 698737005510 trimer interface [polypeptide binding]; other site 698737005511 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 698737005512 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 698737005513 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 698737005514 dimer interface [polypeptide binding]; other site 698737005515 tetramer interface [polypeptide binding]; other site 698737005516 PYR/PP interface [polypeptide binding]; other site 698737005517 TPP binding site [chemical binding]; other site 698737005518 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 698737005519 TPP-binding site; other site 698737005520 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 698737005521 chorismate binding enzyme; Region: Chorismate_bind; cl10555 698737005522 UbiA prenyltransferase family; Region: UbiA; cl00337 698737005523 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 698737005524 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 698737005525 ComK protein; Region: ComK; cl11560 698737005526 IDEAL domain; Region: IDEAL; cl07452 698737005527 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 698737005528 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 698737005529 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 698737005530 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 698737005531 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 698737005532 active site 698737005533 metal binding site [ion binding]; metal-binding site 698737005534 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 698737005535 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 698737005536 Cation transport protein; Region: TrkH; cl10514 698737005537 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 698737005538 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 698737005539 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698737005540 protein binding site [polypeptide binding]; other site 698737005541 Integral membrane protein TerC family; Region: TerC; cl10468 698737005542 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 698737005543 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 698737005544 G1 box; other site 698737005545 putative GEF interaction site [polypeptide binding]; other site 698737005546 GTP/Mg2+ binding site [chemical binding]; other site 698737005547 Switch I region; other site 698737005548 G2 box; other site 698737005549 G3 box; other site 698737005550 Switch II region; other site 698737005551 G4 box; other site 698737005552 G5 box; other site 698737005553 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 698737005554 YueH-like protein; Region: YueH; pfam14166 698737005555 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 698737005556 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698737005557 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698737005558 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698737005559 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 698737005560 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 698737005561 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 698737005562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737005563 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698737005564 putative substrate translocation pore; other site 698737005565 hypothetical protein; Provisional; Region: PRK13679 698737005566 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 698737005567 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 698737005568 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698737005569 DNA binding residues [nucleotide binding] 698737005570 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 698737005571 classical (c) SDRs; Region: SDR_c; cd05233 698737005572 NAD(P) binding site [chemical binding]; other site 698737005573 active site 698737005574 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 698737005575 Putative esterase; Region: Esterase; pfam00756 698737005576 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 698737005577 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 698737005578 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 698737005579 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 698737005580 NAD binding site [chemical binding]; other site 698737005581 homotetramer interface [polypeptide binding]; other site 698737005582 homodimer interface [polypeptide binding]; other site 698737005583 substrate binding site [chemical binding]; other site 698737005584 active site 698737005585 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 698737005586 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 698737005587 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 698737005588 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737005589 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 698737005590 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 698737005591 MgtE intracellular N domain; Region: MgtE_N; cl15244 698737005592 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 698737005593 Divalent cation transporter; Region: MgtE; cl00786 698737005594 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 698737005595 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 698737005596 active site 698737005597 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 698737005598 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 698737005599 synthetase active site [active] 698737005600 NTP binding site [chemical binding]; other site 698737005601 metal binding site [ion binding]; metal-binding site 698737005602 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 698737005603 putative active site [active] 698737005604 putative metal binding residues [ion binding]; other site 698737005605 signature motif; other site 698737005606 putative triphosphate binding site [ion binding]; other site 698737005607 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 698737005608 apolar tunnel; other site 698737005609 heme binding site [chemical binding]; other site 698737005610 dimerization interface [polypeptide binding]; other site 698737005611 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 698737005612 Thioredoxin; Region: Thioredoxin_5; pfam13743 698737005613 catalytic residues [active] 698737005614 oligoendopeptidase F; Region: pepF; TIGR00181 698737005615 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 698737005616 active site 698737005617 Zn binding site [ion binding]; other site 698737005618 Competence protein CoiA-like family; Region: CoiA; cl11541 698737005619 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 698737005620 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 698737005621 ArsC family; Region: ArsC; pfam03960 698737005622 putative catalytic residues [active] 698737005623 thiol/disulfide switch; other site 698737005624 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 698737005625 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 698737005626 active site 698737005627 HIGH motif; other site 698737005628 dimer interface [polypeptide binding]; other site 698737005629 KMSKS motif; other site 698737005630 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698737005631 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698737005632 S-adenosylmethionine binding site [chemical binding]; other site 698737005633 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 698737005634 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 698737005635 peptide binding site [polypeptide binding]; other site 698737005636 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 698737005637 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 698737005638 Walker A/P-loop; other site 698737005639 ATP binding site [chemical binding]; other site 698737005640 Q-loop/lid; other site 698737005641 ABC transporter signature motif; other site 698737005642 Walker B; other site 698737005643 D-loop; other site 698737005644 H-loop/switch region; other site 698737005645 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698737005646 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 698737005647 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 698737005648 Walker A/P-loop; other site 698737005649 ATP binding site [chemical binding]; other site 698737005650 Q-loop/lid; other site 698737005651 ABC transporter signature motif; other site 698737005652 Walker B; other site 698737005653 D-loop; other site 698737005654 H-loop/switch region; other site 698737005655 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698737005656 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 698737005657 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 698737005658 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737005659 dimer interface [polypeptide binding]; other site 698737005660 conserved gate region; other site 698737005661 putative PBP binding loops; other site 698737005662 ABC-ATPase subunit interface; other site 698737005663 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698737005664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737005665 dimer interface [polypeptide binding]; other site 698737005666 ABC-ATPase subunit interface; other site 698737005667 putative PBP binding loops; other site 698737005668 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 698737005669 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 698737005670 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 698737005671 dimer interface [polypeptide binding]; other site 698737005672 active site 698737005673 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 698737005674 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 698737005675 dimer interface [polypeptide binding]; other site 698737005676 active site 698737005677 CoA binding pocket [chemical binding]; other site 698737005678 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 698737005679 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 698737005680 Clp amino terminal domain; Region: Clp_N; pfam02861 698737005681 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698737005682 Walker A motif; other site 698737005683 ATP binding site [chemical binding]; other site 698737005684 Walker B motif; other site 698737005685 arginine finger; other site 698737005686 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698737005687 Walker A motif; other site 698737005688 ATP binding site [chemical binding]; other site 698737005689 Walker B motif; other site 698737005690 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 698737005691 Domain of unknown function DUF59; Region: DUF59; cl00941 698737005692 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698737005693 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698737005694 motif II; other site 698737005695 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 698737005696 coenzyme A disulfide reductase; Provisional; Region: PRK13512 698737005697 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698737005698 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698737005699 Protein of unknown function (DUF1516); Region: DUF1516; cl11654 698737005700 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 698737005701 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 698737005702 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737005703 Family description; Region: UvrD_C_2; cl15862 698737005704 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 698737005705 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 698737005706 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 698737005707 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 698737005708 Catalytic site [active] 698737005709 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 698737005710 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 698737005711 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 698737005712 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 698737005713 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 698737005714 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 698737005715 active site 698737005716 dimer interface [polypeptide binding]; other site 698737005717 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 698737005718 dimer interface [polypeptide binding]; other site 698737005719 active site 698737005720 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 698737005721 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 698737005722 ANP binding site [chemical binding]; other site 698737005723 Substrate Binding Site II [chemical binding]; other site 698737005724 Substrate Binding Site I [chemical binding]; other site 698737005725 argininosuccinate lyase; Provisional; Region: PRK00855 698737005726 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 698737005727 active sites [active] 698737005728 tetramer interface [polypeptide binding]; other site 698737005729 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 698737005730 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 698737005731 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 698737005732 NAD(P) binding site [chemical binding]; other site 698737005733 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 698737005734 putative active site [active] 698737005735 putative FMN binding site [chemical binding]; other site 698737005736 putative substrate binding site [chemical binding]; other site 698737005737 putative catalytic residue [active] 698737005738 general stress protein 13; Validated; Region: PRK08059 698737005739 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 698737005740 RNA binding site [nucleotide binding]; other site 698737005741 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 698737005742 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 698737005743 active site 698737005744 Kinase associated protein B; Region: KapB; pfam08810 698737005745 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 698737005746 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 698737005747 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 698737005748 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 698737005749 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 698737005750 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 698737005751 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 698737005752 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 698737005753 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 698737005754 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 698737005755 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 698737005756 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737005757 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 698737005758 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 698737005759 CoenzymeA binding site [chemical binding]; other site 698737005760 subunit interaction site [polypeptide binding]; other site 698737005761 PHB binding site; other site 698737005762 Predicted permease [General function prediction only]; Region: COG2056 698737005763 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 698737005764 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 698737005765 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 698737005766 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 698737005767 interface (dimer of trimers) [polypeptide binding]; other site 698737005768 Substrate-binding/catalytic site; other site 698737005769 Zn-binding sites [ion binding]; other site 698737005770 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 698737005771 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698737005772 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 698737005773 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698737005774 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 698737005775 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737005776 Walker A/P-loop; other site 698737005777 ATP binding site [chemical binding]; other site 698737005778 Q-loop/lid; other site 698737005779 ABC transporter signature motif; other site 698737005780 Walker B; other site 698737005781 D-loop; other site 698737005782 H-loop/switch region; other site 698737005783 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698737005784 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 698737005785 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737005786 Walker A/P-loop; other site 698737005787 ATP binding site [chemical binding]; other site 698737005788 Q-loop/lid; other site 698737005789 ABC transporter signature motif; other site 698737005790 Walker B; other site 698737005791 D-loop; other site 698737005792 H-loop/switch region; other site 698737005793 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698737005794 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 698737005795 Walker A/P-loop; other site 698737005796 ATP binding site [chemical binding]; other site 698737005797 Q-loop/lid; other site 698737005798 ABC transporter signature motif; other site 698737005799 Walker B; other site 698737005800 D-loop; other site 698737005801 H-loop/switch region; other site 698737005802 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737005803 Walker A/P-loop; other site 698737005804 ATP binding site [chemical binding]; other site 698737005805 Q-loop/lid; other site 698737005806 ABC transporter signature motif; other site 698737005807 Walker B; other site 698737005808 D-loop; other site 698737005809 H-loop/switch region; other site 698737005810 Cobalt transport protein; Region: CbiQ; cl00463 698737005811 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 698737005812 Condensation domain; Region: Condensation; pfam00668 698737005813 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 698737005814 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698737005815 Thioesterase domain; Region: Thioesterase; pfam00975 698737005816 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 698737005817 metal binding site [ion binding]; metal-binding site 698737005818 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737005819 thiazolinyl imide reductase; Region: thiaz-red; TIGR01761 698737005820 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737005821 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737005822 Phosphopantetheine attachment site; Region: PP-binding; cl09936 698737005823 Condensation domain; Region: Condensation; pfam00668 698737005824 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 698737005825 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698737005826 AMP-binding enzyme; Region: AMP-binding; cl15778 698737005827 peptide synthase; Validated; Region: PRK05691 698737005828 Phosphopantetheine attachment site; Region: PP-binding; cl09936 698737005829 Condensation domain; Region: Condensation; pfam00668 698737005830 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 698737005831 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698737005832 Phosphopantetheine attachment site; Region: PP-binding; cl09936 698737005833 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 698737005834 AMP-binding enzyme; Region: AMP-binding; cl15778 698737005835 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 698737005836 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 698737005837 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 698737005838 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 698737005839 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 698737005840 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 698737005841 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698737005842 Protein of unknown function (DUF1462); Region: DUF1462; cl11552 698737005843 NifU-like domain; Region: NifU; cl00484 698737005844 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 698737005845 DltD N-terminal region; Region: DltD_N; pfam04915 698737005846 DltD central region; Region: DltD_M; pfam04918 698737005847 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 698737005848 Phosphopantetheine attachment site; Region: PP-binding; cl09936 698737005849 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 698737005850 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 698737005851 AMP-binding enzyme; Region: AMP-binding; cl15778 698737005852 glyoxylate reductase; Reviewed; Region: PRK13243 698737005853 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737005854 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 698737005855 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698737005856 active site 698737005857 motif I; other site 698737005858 motif II; other site 698737005859 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698737005860 Protein of unknown function DUF86; Region: DUF86; cl01031 698737005861 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 698737005862 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 698737005863 lipoyl synthase; Provisional; Region: PRK05481 698737005864 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698737005865 FeS/SAM binding site; other site 698737005866 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 698737005867 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 698737005868 active site 698737005869 metal binding site [ion binding]; metal-binding site 698737005870 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 698737005871 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 698737005872 Protein of unknown function DUF72; Region: DUF72; cl00777 698737005873 Nitronate monooxygenase; Region: NMO; pfam03060 698737005874 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 698737005875 FMN binding site [chemical binding]; other site 698737005876 substrate binding site [chemical binding]; other site 698737005877 putative catalytic residue [active] 698737005878 Domain of unknown function DUF21; Region: DUF21; pfam01595 698737005879 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698737005880 Protein of unknown function, DUF600; Region: DUF600; cl04640 698737005881 Protein of unknown function, DUF600; Region: DUF600; cl04640 698737005882 Protein of unknown function, DUF600; Region: DUF600; cl04640 698737005883 LXG domain of WXG superfamily; Region: LXG; pfam04740 698737005884 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 698737005885 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 698737005886 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737005887 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737005888 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 698737005889 Ubiquitin-like proteins; Region: UBQ; cl00155 698737005890 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 698737005891 Predicted membrane protein [Function unknown]; Region: COG1511 698737005892 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 698737005893 Predicted membrane protein [Function unknown]; Region: COG1511 698737005894 Colicin V production protein; Region: Colicin_V; cl00567 698737005895 Proteins of 100 residues with WXG; Region: WXG100; cl02005 698737005896 Surface antigen [General function prediction only]; Region: COG3942 698737005897 NlpC/P60 family; Region: NLPC_P60; cl11438 698737005898 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 698737005899 FeS assembly protein SufB; Region: sufB; TIGR01980 698737005900 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 698737005901 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 698737005902 trimerization site [polypeptide binding]; other site 698737005903 active site 698737005904 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 698737005905 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 698737005906 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698737005907 catalytic residue [active] 698737005908 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 698737005909 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 698737005910 FeS assembly ATPase SufC; Region: sufC; TIGR01978 698737005911 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 698737005912 Walker A/P-loop; other site 698737005913 ATP binding site [chemical binding]; other site 698737005914 Q-loop/lid; other site 698737005915 ABC transporter signature motif; other site 698737005916 Walker B; other site 698737005917 D-loop; other site 698737005918 H-loop/switch region; other site 698737005919 Domain of unknown function (DUF368); Region: DUF368; cl00893 698737005920 CsbD-like; Region: CsbD; cl15799 698737005921 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698737005922 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698737005923 intersubunit interface [polypeptide binding]; other site 698737005924 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 698737005925 Preprotein binding site; other site 698737005926 SecA binding site; other site 698737005927 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698737005928 putative DNA binding site [nucleotide binding]; other site 698737005929 putative Zn2+ binding site [ion binding]; other site 698737005930 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 698737005931 Cadmium resistance transporter; Region: Cad; cl04177 698737005932 Terminase small subunit; Region: Terminase_2; cl01513 698737005933 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 698737005934 Virulence-associated protein E; Region: VirE; pfam05272 698737005935 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 698737005936 Protein of unknown function (DUF1474); Region: DUF1474; pfam07342 698737005937 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698737005938 non-specific DNA binding site [nucleotide binding]; other site 698737005939 salt bridge; other site 698737005940 sequence-specific DNA binding site [nucleotide binding]; other site 698737005941 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698737005942 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698737005943 non-specific DNA binding site [nucleotide binding]; other site 698737005944 salt bridge; other site 698737005945 sequence-specific DNA binding site [nucleotide binding]; other site 698737005946 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 698737005947 Int/Topo IB signature motif; other site 698737005948 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 698737005949 NMT1-like family; Region: NMT1_2; cl15260 698737005950 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737005951 dimer interface [polypeptide binding]; other site 698737005952 conserved gate region; other site 698737005953 ABC-ATPase subunit interface; other site 698737005954 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 698737005955 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 698737005956 Walker A/P-loop; other site 698737005957 ATP binding site [chemical binding]; other site 698737005958 Q-loop/lid; other site 698737005959 ABC transporter signature motif; other site 698737005960 Walker B; other site 698737005961 D-loop; other site 698737005962 H-loop/switch region; other site 698737005963 NIL domain; Region: NIL; cl09633 698737005964 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698737005965 catalytic residues [active] 698737005966 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 698737005967 putative active site [active] 698737005968 putative metal binding site [ion binding]; other site 698737005969 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 698737005970 lipoyl attachment site [posttranslational modification]; other site 698737005971 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 698737005972 ArsC family; Region: ArsC; pfam03960 698737005973 putative ArsC-like catalytic residues; other site 698737005974 putative TRX-like catalytic residues [active] 698737005975 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698737005976 catalytic residues [active] 698737005977 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 698737005978 putative FMN binding site [chemical binding]; other site 698737005979 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 698737005980 active site 698737005981 catalytic residue [active] 698737005982 dimer interface [polypeptide binding]; other site 698737005983 OsmC-like protein; Region: OsmC; cl00767 698737005984 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 698737005985 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 698737005986 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698737005987 catalytic core [active] 698737005988 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 698737005989 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 698737005990 Protein of unknown function (DUF867); Region: DUF867; cl01713 698737005991 DoxX; Region: DoxX; cl00976 698737005992 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 698737005993 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698737005994 active site 698737005995 metal binding site [ion binding]; metal-binding site 698737005996 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 698737005997 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 698737005998 PhoD-like phosphatase; Region: PhoD; pfam09423 698737005999 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698737006000 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 698737006001 active site 698737006002 metal binding site [ion binding]; metal-binding site 698737006003 Protein of unknown function, DUF576; Region: DUF576; cl04553 698737006004 Cation efflux family; Region: Cation_efflux; cl00316 698737006005 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 698737006006 H+ Antiporter protein; Region: 2A0121; TIGR00900 698737006007 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698737006008 active site residue [active] 698737006009 Helix-turn-helix domains; Region: HTH; cl00088 698737006010 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698737006011 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 698737006012 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 698737006013 SmpB-tmRNA interface; other site 698737006014 ribonuclease R; Region: RNase_R; TIGR02063 698737006015 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698737006016 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698737006017 RNB domain; Region: RNB; pfam00773 698737006018 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 698737006019 RNA binding site [nucleotide binding]; other site 698737006020 Esterase/lipase [General function prediction only]; Region: COG1647 698737006021 Preprotein translocase SecG subunit; Region: SecG; cl09123 698737006022 enolase; Provisional; Region: eno; PRK00077 698737006023 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 698737006024 dimer interface [polypeptide binding]; other site 698737006025 metal binding site [ion binding]; metal-binding site 698737006026 substrate binding pocket [chemical binding]; other site 698737006027 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 698737006028 Sulfatase; Region: Sulfatase; cl10460 698737006029 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 698737006030 substrate binding site [chemical binding]; other site 698737006031 dimer interface [polypeptide binding]; other site 698737006032 catalytic triad [active] 698737006033 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 698737006034 Phosphoglycerate kinase; Region: PGK; pfam00162 698737006035 substrate binding site [chemical binding]; other site 698737006036 hinge regions; other site 698737006037 ADP binding site [chemical binding]; other site 698737006038 catalytic site [active] 698737006039 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737006040 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 698737006041 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 698737006042 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 698737006043 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 698737006044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737006045 TIGR01777 family protein; Region: yfcH 698737006046 NAD(P) binding site [chemical binding]; other site 698737006047 active site 698737006048 Clp protease; Region: CLP_protease; pfam00574 698737006049 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 698737006050 oligomer interface [polypeptide binding]; other site 698737006051 active site residues [active] 698737006052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 698737006053 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 698737006054 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 698737006055 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 698737006056 phosphate binding site [ion binding]; other site 698737006057 putative substrate binding pocket [chemical binding]; other site 698737006058 dimer interface [polypeptide binding]; other site 698737006059 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 698737006060 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 698737006061 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 698737006062 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737006063 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698737006064 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698737006065 binding surface 698737006066 TPR motif; other site 698737006067 putative acyl transferase; Provisional; Region: PRK10191 698737006068 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 698737006069 trimer interface [polypeptide binding]; other site 698737006070 active site 698737006071 substrate binding site [chemical binding]; other site 698737006072 CoA binding site [chemical binding]; other site 698737006073 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 698737006074 HPr kinase/phosphorylase; Provisional; Region: PRK05428 698737006075 DRTGG domain; Region: DRTGG; cl12147 698737006076 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 698737006077 Hpr binding site; other site 698737006078 active site 698737006079 homohexamer subunit interaction site [polypeptide binding]; other site 698737006080 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 698737006081 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 698737006082 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 698737006083 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 698737006084 excinuclease ABC subunit B; Provisional; Region: PRK05298 698737006085 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698737006086 ATP binding site [chemical binding]; other site 698737006087 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698737006088 nucleotide binding region [chemical binding]; other site 698737006089 ATP-binding site [chemical binding]; other site 698737006090 Ultra-violet resistance protein B; Region: UvrB; pfam12344 698737006091 UvrB/uvrC motif; Region: UVR; pfam02151 698737006092 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 698737006093 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 698737006094 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 698737006095 NlpC/P60 family; Region: NLPC_P60; cl11438 698737006096 peptide chain release factor 2; Provisional; Region: PRK06746 698737006097 RF-1 domain; Region: RF-1; cl02875 698737006098 RF-1 domain; Region: RF-1; cl02875 698737006099 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 698737006100 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 698737006101 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737006102 nucleotide binding region [chemical binding]; other site 698737006103 SEC-C motif; Region: SEC-C; pfam02810 698737006104 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 698737006105 amidase catalytic site [active] 698737006106 Zn binding residues [ion binding]; other site 698737006107 substrate binding site [chemical binding]; other site 698737006108 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 698737006109 30S subunit binding site; other site 698737006110 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 698737006111 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698737006112 active site 698737006113 DEAD-like helicases superfamily; Region: DEXDc; smart00487 698737006114 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698737006115 ATP binding site [chemical binding]; other site 698737006116 putative Mg++ binding site [ion binding]; other site 698737006117 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698737006118 nucleotide binding region [chemical binding]; other site 698737006119 ATP-binding site [chemical binding]; other site 698737006120 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 698737006121 Uncharacterized conserved protein [Function unknown]; Region: COG1739 698737006122 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 698737006123 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 698737006124 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 698737006125 Mg++ binding site [ion binding]; other site 698737006126 putative catalytic motif [active] 698737006127 substrate binding site [chemical binding]; other site 698737006128 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 698737006129 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698737006130 metal binding site [ion binding]; metal-binding site 698737006131 active site 698737006132 I-site; other site 698737006133 Uncharacterized conserved protein [Function unknown]; Region: COG2966 698737006134 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 698737006135 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 698737006136 peptidase T; Region: peptidase-T; TIGR01882 698737006137 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 698737006138 metal binding site [ion binding]; metal-binding site 698737006139 dimer interface [polypeptide binding]; other site 698737006140 Glycerate kinase family; Region: Gly_kinase; cl00841 698737006141 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 698737006142 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 698737006143 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906 698737006144 FAD binding domain; Region: FAD_binding_4; pfam01565 698737006145 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 698737006146 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 698737006147 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 698737006148 putative ligand binding residues [chemical binding]; other site 698737006149 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 698737006150 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698737006151 Walker A/P-loop; other site 698737006152 ATP binding site [chemical binding]; other site 698737006153 Q-loop/lid; other site 698737006154 ABC transporter signature motif; other site 698737006155 Walker B; other site 698737006156 D-loop; other site 698737006157 H-loop/switch region; other site 698737006158 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698737006159 ABC-ATPase subunit interface; other site 698737006160 dimer interface [polypeptide binding]; other site 698737006161 putative PBP binding regions; other site 698737006162 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698737006163 ABC-ATPase subunit interface; other site 698737006164 dimer interface [polypeptide binding]; other site 698737006165 putative PBP binding regions; other site 698737006166 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 698737006167 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698737006168 intersubunit interface [polypeptide binding]; other site 698737006169 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 698737006170 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698737006171 Walker A/P-loop; other site 698737006172 ATP binding site [chemical binding]; other site 698737006173 Q-loop/lid; other site 698737006174 ABC transporter signature motif; other site 698737006175 Walker B; other site 698737006176 D-loop; other site 698737006177 H-loop/switch region; other site 698737006178 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698737006179 ABC-ATPase subunit interface; other site 698737006180 dimer interface [polypeptide binding]; other site 698737006181 putative PBP binding regions; other site 698737006182 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698737006183 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698737006184 ABC-ATPase subunit interface; other site 698737006185 dimer interface [polypeptide binding]; other site 698737006186 putative PBP binding regions; other site 698737006187 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 698737006188 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 698737006189 dimer interface [polypeptide binding]; other site 698737006190 putative radical transfer pathway; other site 698737006191 diiron center [ion binding]; other site 698737006192 tyrosyl radical; other site 698737006193 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 698737006194 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 698737006195 Class I ribonucleotide reductase; Region: RNR_I; cd01679 698737006196 active site 698737006197 dimer interface [polypeptide binding]; other site 698737006198 catalytic residues [active] 698737006199 effector binding site; other site 698737006200 R2 peptide binding site; other site 698737006201 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 698737006202 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 698737006203 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 698737006204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737006205 putative substrate translocation pore; other site 698737006206 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 698737006207 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 698737006208 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 698737006209 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 698737006210 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 698737006211 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698737006212 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737006213 homodimer interface [polypeptide binding]; other site 698737006214 catalytic residue [active] 698737006215 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 698737006216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 698737006217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737006218 dimer interface [polypeptide binding]; other site 698737006219 conserved gate region; other site 698737006220 ABC-ATPase subunit interface; other site 698737006221 NMT1-like family; Region: NMT1_2; cl15260 698737006222 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 698737006223 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 698737006224 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 698737006225 Walker A/P-loop; other site 698737006226 ATP binding site [chemical binding]; other site 698737006227 Q-loop/lid; other site 698737006228 ABC transporter signature motif; other site 698737006229 Walker B; other site 698737006230 D-loop; other site 698737006231 H-loop/switch region; other site 698737006232 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 698737006233 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698737006234 ATP binding site [chemical binding]; other site 698737006235 putative Mg++ binding site [ion binding]; other site 698737006236 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698737006237 nucleotide binding region [chemical binding]; other site 698737006238 ATP-binding site [chemical binding]; other site 698737006239 RQC domain; Region: RQC; cl09632 698737006240 HRDC domain; Region: HRDC; cl02578 698737006241 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698737006242 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737006243 Walker A/P-loop; other site 698737006244 ATP binding site [chemical binding]; other site 698737006245 Q-loop/lid; other site 698737006246 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 698737006247 ABC transporter; Region: ABC_tran_2; pfam12848 698737006248 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 698737006249 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 698737006250 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 698737006251 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 698737006252 Sulfatase; Region: Sulfatase; cl10460 698737006253 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 698737006254 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 698737006255 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 698737006256 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 698737006257 substrate-cofactor binding pocket; other site 698737006258 homodimer interface [polypeptide binding]; other site 698737006259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737006260 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 698737006261 chorismate binding enzyme; Region: Chorismate_bind; cl10555 698737006262 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 698737006263 Glutamine amidotransferase class-I; Region: GATase; pfam00117 698737006264 glutamine binding [chemical binding]; other site 698737006265 catalytic triad [active] 698737006266 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 698737006267 Ligand Binding Site [chemical binding]; other site 698737006268 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 698737006269 active site 698737006270 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 698737006271 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 698737006272 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 698737006273 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 698737006274 Ligand binding site; other site 698737006275 Putative Catalytic site; other site 698737006276 DXD motif; other site 698737006277 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698737006278 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698737006279 active site 698737006280 catalytic tetrad [active] 698737006281 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698737006282 Domain of unknown function DUF21; Region: DUF21; pfam01595 698737006283 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698737006284 Transporter associated domain; Region: CorC_HlyC; cl08393 698737006285 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 698737006286 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 698737006287 active site 698737006288 phosphorylation site [posttranslational modification] 698737006289 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 698737006290 P-loop; other site 698737006291 active site 698737006292 phosphorylation site [posttranslational modification] 698737006293 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 698737006294 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 698737006295 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 698737006296 putative substrate binding site [chemical binding]; other site 698737006297 putative ATP binding site [chemical binding]; other site 698737006298 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 698737006299 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 698737006300 putative deacylase active site [active] 698737006301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737006302 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698737006303 putative substrate translocation pore; other site 698737006304 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 698737006305 DNA photolyase; Region: DNA_photolyase; pfam00875 698737006306 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 698737006307 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 698737006308 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 698737006309 transmembrane helices; other site 698737006310 malate dehydrogenase; Reviewed; Region: PRK06223 698737006311 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 698737006312 NAD(P) binding site [chemical binding]; other site 698737006313 dimer interface [polypeptide binding]; other site 698737006314 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698737006315 substrate binding site [chemical binding]; other site 698737006316 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 698737006317 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737006318 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 698737006319 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698737006320 Helix-turn-helix domains; Region: HTH; cl00088 698737006321 Bacitracin resistance protein BacA; Region: BacA; cl00858 698737006322 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 698737006323 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 698737006324 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 698737006325 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 698737006326 Protein of unknown function (DUF456); Region: DUF456; cl01069 698737006327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737006328 sugar efflux transporter; Region: 2A0120; TIGR00899 698737006329 putative substrate translocation pore; other site 698737006330 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698737006331 Helix-turn-helix domains; Region: HTH; cl00088 698737006332 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 698737006333 dimerization interface [polypeptide binding]; other site 698737006334 Protein of unknown function (DUF402); Region: DUF402; cl00979 698737006335 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 698737006336 Transcriptional regulator; Region: Transcrip_reg; cl00361 698737006337 Helix-turn-helix domains; Region: HTH; cl00088 698737006338 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 698737006339 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698737006340 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 698737006341 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 698737006342 putative peptidoglycan binding site; other site 698737006343 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 698737006344 putative peptidoglycan binding site; other site 698737006345 NlpC/P60 family; Region: NLPC_P60; cl11438 698737006346 Phosphate transporter family; Region: PHO4; cl00396 698737006347 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 698737006348 FtsX-like permease family; Region: FtsX; cl15850 698737006349 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698737006350 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 698737006351 Walker A/P-loop; other site 698737006352 ATP binding site [chemical binding]; other site 698737006353 Q-loop/lid; other site 698737006354 ABC transporter signature motif; other site 698737006355 Walker B; other site 698737006356 D-loop; other site 698737006357 H-loop/switch region; other site 698737006358 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698737006359 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 698737006360 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737006361 ATP binding site [chemical binding]; other site 698737006362 Mg2+ binding site [ion binding]; other site 698737006363 G-X-G motif; other site 698737006364 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698737006365 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698737006366 active site 698737006367 phosphorylation site [posttranslational modification] 698737006368 intermolecular recognition site; other site 698737006369 dimerization interface [polypeptide binding]; other site 698737006370 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698737006371 DNA binding site [nucleotide binding] 698737006372 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737006373 NAD(P) binding site [chemical binding]; other site 698737006374 active site 698737006375 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 698737006376 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698737006377 Coenzyme A binding pocket [chemical binding]; other site 698737006378 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 698737006379 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 698737006380 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 698737006381 Uncharacterized membrane protein [Function unknown]; Region: COG3949 698737006382 Protein of unknown function (DUF3192); Region: DUF3192; pfam11399 698737006383 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 698737006384 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698737006385 ABC-ATPase subunit interface; other site 698737006386 dimer interface [polypeptide binding]; other site 698737006387 putative PBP binding regions; other site 698737006388 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698737006389 ABC-ATPase subunit interface; other site 698737006390 dimer interface [polypeptide binding]; other site 698737006391 putative PBP binding regions; other site 698737006392 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698737006393 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698737006394 Walker A/P-loop; other site 698737006395 ATP binding site [chemical binding]; other site 698737006396 Q-loop/lid; other site 698737006397 ABC transporter signature motif; other site 698737006398 Walker B; other site 698737006399 D-loop; other site 698737006400 H-loop/switch region; other site 698737006401 Uncharacterized conserved protein [Function unknown]; Region: COG1284 698737006402 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 698737006403 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 698737006404 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 698737006405 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 698737006406 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 698737006407 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 698737006408 active site 698737006409 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 698737006410 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 698737006411 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 698737006412 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698737006413 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 698737006414 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737006415 Walker A/P-loop; other site 698737006416 ATP binding site [chemical binding]; other site 698737006417 Q-loop/lid; other site 698737006418 ABC transporter signature motif; other site 698737006419 Walker B; other site 698737006420 D-loop; other site 698737006421 H-loop/switch region; other site 698737006422 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 698737006423 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 698737006424 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 698737006425 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698737006426 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 698737006427 active site 698737006428 nucleotide binding site [chemical binding]; other site 698737006429 HIGH motif; other site 698737006430 KMSKS motif; other site 698737006431 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 698737006432 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 698737006433 active site 698737006434 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 698737006435 ABC-2 type transporter; Region: ABC2_membrane; cl11417 698737006436 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 698737006437 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 698737006438 Walker A/P-loop; other site 698737006439 ATP binding site [chemical binding]; other site 698737006440 Q-loop/lid; other site 698737006441 ABC transporter signature motif; other site 698737006442 Walker B; other site 698737006443 D-loop; other site 698737006444 H-loop/switch region; other site 698737006445 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 698737006446 formate dehydrogenase; Provisional; Region: PRK07574 698737006447 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737006448 putative myristoylated protein; Provisional; Region: PHA03056 698737006449 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 698737006450 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 698737006451 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 698737006452 Helix-turn-helix domains; Region: HTH; cl00088 698737006453 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 698737006454 FeoA domain; Region: FeoA; cl00838 698737006455 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 698737006456 ABC transporter; Region: ABC_tran; pfam00005 698737006457 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698737006458 ABC-ATPase subunit interface; other site 698737006459 dimer interface [polypeptide binding]; other site 698737006460 putative PBP binding regions; other site 698737006461 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 698737006462 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698737006463 metal binding site [ion binding]; metal-binding site 698737006464 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 698737006465 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 698737006466 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 698737006467 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 698737006468 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 698737006469 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 698737006470 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 698737006471 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 698737006472 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 698737006473 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646 698737006474 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 698737006475 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 698737006476 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 698737006477 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698737006478 DNA binding site [nucleotide binding] 698737006479 Int/Topo IB signature motif; other site 698737006480 active site 698737006481 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 698737006482 Protein of unknown function, DUF606; Region: DUF606; cl01273 698737006483 Protein of unknown function, DUF606; Region: DUF606; cl01273 698737006484 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698737006485 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 698737006486 Helix-turn-helix domains; Region: HTH; cl00088 698737006487 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698737006488 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 698737006489 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 698737006490 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 698737006491 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698737006492 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 698737006493 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698737006494 motif II; other site 698737006495 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698737006496 ABC-ATPase subunit interface; other site 698737006497 dimer interface [polypeptide binding]; other site 698737006498 putative PBP binding regions; other site 698737006499 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 698737006500 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 698737006501 putative binding site residues; other site 698737006502 Protein of unknown function (DUF805); Region: DUF805; cl01224 698737006503 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 698737006504 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698737006505 DNA binding residues [nucleotide binding] 698737006506 dimer interface [polypeptide binding]; other site 698737006507 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 698737006508 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 698737006509 minor groove reading motif; other site 698737006510 helix-hairpin-helix signature motif; other site 698737006511 substrate binding pocket [chemical binding]; other site 698737006512 active site 698737006513 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 698737006514 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 698737006515 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 698737006516 active site 698737006517 HIGH motif; other site 698737006518 KMSK motif region; other site 698737006519 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 698737006520 tRNA binding surface [nucleotide binding]; other site 698737006521 anticodon binding site; other site 698737006522 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 698737006523 Cupin domain; Region: Cupin_2; cl09118 698737006524 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 698737006525 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 698737006526 NAD binding site [chemical binding]; other site 698737006527 substrate binding site [chemical binding]; other site 698737006528 catalytic Zn binding site [ion binding]; other site 698737006529 tetramer interface [polypeptide binding]; other site 698737006530 structural Zn binding site [ion binding]; other site 698737006531 YwhD family; Region: YwhD; pfam08741 698737006532 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 698737006533 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698737006534 Zn2+ binding site [ion binding]; other site 698737006535 Mg2+ binding site [ion binding]; other site 698737006536 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 698737006537 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698737006538 Coenzyme A binding pocket [chemical binding]; other site 698737006539 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 698737006540 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 698737006541 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698737006542 active site 698737006543 catalytic tetrad [active] 698737006544 Predicted transcriptional regulator [Transcription]; Region: COG1959 698737006545 Helix-turn-helix domains; Region: HTH; cl00088 698737006546 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737006547 NlpC/P60 family; Region: NLPC_P60; cl11438 698737006548 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 698737006549 amidase catalytic site [active] 698737006550 Zn binding residues [ion binding]; other site 698737006551 substrate binding site [chemical binding]; other site 698737006552 Bacterial SH3 domain; Region: SH3_3; cl02551 698737006553 Bacteriophage holin; Region: Phage_holin_1; cl02344 698737006554 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 698737006555 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 698737006556 active site 698737006557 oxyanion hole [active] 698737006558 catalytic triad [active] 698737006559 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 698737006560 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 698737006561 hypothetical protein; Region: PHA01795 698737006562 Phage tail protein; Region: Sipho_tail; pfam05709 698737006563 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 698737006564 Phage-related protein [Function unknown]; Region: COG5412 698737006565 membrane protein P6; Region: PHA01399 698737006566 Phage protein; Region: DUF3647; cl10335 698737006567 Phage major tail protein 2; Region: Phage_tail_2; cl11463 698737006568 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 698737006569 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 698737006570 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 698737006571 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 698737006572 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 698737006573 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 698737006574 Phage terminase large subunit; Region: Terminase_3; cl12054 698737006575 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 698737006576 Transcriptional activator RinB; Region: RinB; pfam06116 698737006577 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 698737006578 Dimeric dUTPase [Carbohydrate transport and metabolism]; Region: COG4508 698737006579 dUTPase; Region: dUTPase_2; pfam08761 698737006580 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 698737006581 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 698737006582 Endodeoxyribonuclease RusA; Region: RusA; cl01885 698737006583 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 698737006584 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 698737006585 Walker A motif; other site 698737006586 ATP binding site [chemical binding]; other site 698737006587 Walker B motif; other site 698737006588 DNA binding loops [nucleotide binding] 698737006589 potential frameshift: common BLAST hit: gi|88195753|ref|YP_500562.1| phi PV83 orf 20-like protein 698737006590 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 698737006591 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; cl09889 698737006592 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 698737006593 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 698737006594 dimer interface [polypeptide binding]; other site 698737006595 ssDNA binding site [nucleotide binding]; other site 698737006596 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698737006597 ERF superfamily; Region: ERF; pfam04404 698737006598 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 698737006599 AntA/AntB antirepressor; Region: AntA; cl01430 698737006600 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 698737006601 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698737006602 non-specific DNA binding site [nucleotide binding]; other site 698737006603 salt bridge; other site 698737006604 sequence-specific DNA binding site [nucleotide binding]; other site 698737006605 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698737006606 non-specific DNA binding site [nucleotide binding]; other site 698737006607 salt bridge; other site 698737006608 sequence-specific DNA binding site [nucleotide binding]; other site 698737006609 Domain of unknown function (DUF955); Region: DUF955; cl01076 698737006610 Abi-like protein; Region: Abi_2; cl01988 698737006611 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 698737006612 catalytic residues [active] 698737006613 catalytic nucleophile [active] 698737006614 Presynaptic Site I dimer interface [polypeptide binding]; other site 698737006615 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 698737006616 Synaptic Flat tetramer interface [polypeptide binding]; other site 698737006617 Synaptic Site I dimer interface [polypeptide binding]; other site 698737006618 DNA binding site [nucleotide binding] 698737006619 Recombinase; Region: Recombinase; pfam07508 698737006620 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 698737006621 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 698737006622 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698737006623 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698737006624 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 698737006625 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 698737006626 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 698737006627 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 698737006628 mevalonate kinase; Region: mevalon_kin; TIGR00549 698737006629 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 698737006630 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 698737006631 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 698737006632 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 698737006633 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 698737006634 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 698737006635 Chlorite dismutase; Region: Chlor_dismutase; cl01280 698737006636 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 698737006637 Uncharacterized conserved protein [Function unknown]; Region: COG2966 698737006638 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 698737006639 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 698737006640 Spore germination protein; Region: Spore_permease; cl15802 698737006641 Protein of unknown function (DUF423); Region: DUF423; cl01008 698737006642 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 698737006643 ligand binding site [chemical binding]; other site 698737006644 active site 698737006645 UGI interface [polypeptide binding]; other site 698737006646 catalytic site [active] 698737006647 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 698737006648 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 698737006649 active site 698737006650 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 698737006651 dimer interface [polypeptide binding]; other site 698737006652 substrate binding site [chemical binding]; other site 698737006653 ATP binding site [chemical binding]; other site 698737006654 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737006655 cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276 698737006656 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 698737006657 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 698737006658 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 698737006659 proline/glycine betaine transporter; Provisional; Region: PRK10642 698737006660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737006661 putative substrate translocation pore; other site 698737006662 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 698737006663 tetramer interface [polypeptide binding]; other site 698737006664 Predicted sugar phosphate isomerase involved in capsule formation [Cell envelope biogenesis, outer membrane]; Region: GutQ; COG0794 698737006665 active site 698737006666 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 698737006667 active site 698737006668 dimer interface [polypeptide binding]; other site 698737006669 magnesium binding site [ion binding]; other site 698737006670 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 698737006671 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 698737006672 Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642 698737006673 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 698737006674 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 698737006675 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 698737006676 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 698737006677 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 698737006678 active site 698737006679 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 698737006680 heme uptake protein IsdB; Region: IsdB; TIGR03657 698737006681 Rib/alpha-like repeat; Region: Rib; cl07159 698737006682 Rib/alpha-like repeat; Region: Rib; cl07159 698737006683 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 698737006684 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698737006685 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698737006686 active site 698737006687 motif I; other site 698737006688 motif II; other site 698737006689 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 698737006690 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 698737006691 nucleoside/Zn binding site; other site 698737006692 dimer interface [polypeptide binding]; other site 698737006693 catalytic motif [active] 698737006694 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 698737006695 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 698737006696 Substrate-binding site [chemical binding]; other site 698737006697 Substrate specificity [chemical binding]; other site 698737006698 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 698737006699 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 698737006700 Substrate-binding site [chemical binding]; other site 698737006701 Substrate specificity [chemical binding]; other site 698737006702 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 698737006703 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698737006704 motif II; other site 698737006705 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 698737006706 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 698737006707 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737006708 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 698737006709 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 698737006710 tetramer interface [polypeptide binding]; other site 698737006711 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737006712 catalytic residue [active] 698737006713 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 698737006714 Spore germination protein; Region: Spore_permease; cl15802 698737006715 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 698737006716 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 698737006717 homodimer interface [polypeptide binding]; other site 698737006718 substrate-cofactor binding pocket; other site 698737006719 catalytic residue [active] 698737006720 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 698737006721 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737006722 NAD(P) binding site [chemical binding]; other site 698737006723 active site 698737006724 potential frameshift: common BLAST hit: gi|224475581|ref|YP_002633187.1| LysE type translocator 698737006725 LysE type translocator; Region: LysE; cl00565 698737006726 LysE type translocator; Region: LysE; cl00565 698737006727 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 698737006728 nudix motif; other site 698737006729 Predicted acetyltransferase [General function prediction only]; Region: COG3981 698737006730 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 698737006731 ornithine cyclodeaminase; Validated; Region: PRK08618 698737006732 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737006733 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 698737006734 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 698737006735 substrate-cofactor binding pocket; other site 698737006736 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737006737 catalytic residue [active] 698737006738 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698737006739 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 698737006740 metal binding site [ion binding]; metal-binding site 698737006741 dimer interface [polypeptide binding]; other site 698737006742 elongation factor Tu; Reviewed; Region: PRK00049 698737006743 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 698737006744 G1 box; other site 698737006745 GEF interaction site [polypeptide binding]; other site 698737006746 GTP/Mg2+ binding site [chemical binding]; other site 698737006747 Switch I region; other site 698737006748 G2 box; other site 698737006749 G3 box; other site 698737006750 Switch II region; other site 698737006751 G4 box; other site 698737006752 G5 box; other site 698737006753 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 698737006754 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 698737006755 Antibiotic Binding Site [chemical binding]; other site 698737006756 elongation factor G; Reviewed; Region: PRK00007 698737006757 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 698737006758 G1 box; other site 698737006759 putative GEF interaction site [polypeptide binding]; other site 698737006760 GTP/Mg2+ binding site [chemical binding]; other site 698737006761 Switch I region; other site 698737006762 G2 box; other site 698737006763 G3 box; other site 698737006764 Switch II region; other site 698737006765 G4 box; other site 698737006766 G5 box; other site 698737006767 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 698737006768 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 698737006769 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 698737006770 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 698737006771 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 698737006772 S17 interaction site [polypeptide binding]; other site 698737006773 S8 interaction site; other site 698737006774 16S rRNA interaction site [nucleotide binding]; other site 698737006775 streptomycin interaction site [chemical binding]; other site 698737006776 23S rRNA interaction site [nucleotide binding]; other site 698737006777 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 698737006778 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 698737006779 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 698737006780 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 698737006781 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 698737006782 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 698737006783 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 698737006784 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 698737006785 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 698737006786 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 698737006787 G-loop; other site 698737006788 DNA binding site [nucleotide binding] 698737006789 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 698737006790 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 698737006791 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 698737006792 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 698737006793 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 698737006794 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 698737006795 RPB11 interaction site [polypeptide binding]; other site 698737006796 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 698737006797 RPB12 interaction site [polypeptide binding]; other site 698737006798 RPB10 interaction site [polypeptide binding]; other site 698737006799 RPB1 interaction site [polypeptide binding]; other site 698737006800 RPB11 interaction site [polypeptide binding]; other site 698737006801 RPB3 interaction site [polypeptide binding]; other site 698737006802 RPB12 interaction site [polypeptide binding]; other site 698737006803 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698737006804 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698737006805 S-adenosylmethionine binding site [chemical binding]; other site 698737006806 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 698737006807 peripheral dimer interface [polypeptide binding]; other site 698737006808 core dimer interface [polypeptide binding]; other site 698737006809 L10 interface [polypeptide binding]; other site 698737006810 L11 interface [polypeptide binding]; other site 698737006811 putative EF-Tu interaction site [polypeptide binding]; other site 698737006812 putative EF-G interaction site [polypeptide binding]; other site 698737006813 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 698737006814 23S rRNA interface [nucleotide binding]; other site 698737006815 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 698737006816 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 698737006817 mRNA/rRNA interface [nucleotide binding]; other site 698737006818 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 698737006819 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 698737006820 23S rRNA interface [nucleotide binding]; other site 698737006821 L7/L12 interface [polypeptide binding]; other site 698737006822 putative thiostrepton binding site; other site 698737006823 L25 interface [polypeptide binding]; other site 698737006824 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 698737006825 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 698737006826 putative homodimer interface [polypeptide binding]; other site 698737006827 KOW motif; Region: KOW; cl00354 698737006828 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 698737006829 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 698737006830 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698737006831 YacP-like NYN domain; Region: NYN_YacP; cl01491 698737006832 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 698737006833 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 698737006834 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 698737006835 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 698737006836 active site 698737006837 metal binding site [ion binding]; metal-binding site 698737006838 dimerization interface [polypeptide binding]; other site 698737006839 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 698737006840 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 698737006841 active site 698737006842 HIGH motif; other site 698737006843 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 698737006844 KMSKS motif; other site 698737006845 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 698737006846 tRNA binding surface [nucleotide binding]; other site 698737006847 anticodon binding site; other site 698737006848 serine O-acetyltransferase; Region: cysE; TIGR01172 698737006849 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 698737006850 trimer interface [polypeptide binding]; other site 698737006851 active site 698737006852 substrate binding site [chemical binding]; other site 698737006853 CoA binding site [chemical binding]; other site 698737006854 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 698737006855 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 698737006856 active site 698737006857 HIGH motif; other site 698737006858 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 698737006859 active site 698737006860 KMSKS motif; other site 698737006861 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 698737006862 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 698737006863 putative active site [active] 698737006864 DNA repair protein RadA; Provisional; Region: PRK11823 698737006865 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 698737006866 Walker A motif/ATP binding site; other site 698737006867 ATP binding site [chemical binding]; other site 698737006868 Walker B motif; other site 698737006869 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 698737006870 Clp protease ATP binding subunit; Region: clpC; CHL00095 698737006871 Clp amino terminal domain; Region: Clp_N; pfam02861 698737006872 Clp amino terminal domain; Region: Clp_N; pfam02861 698737006873 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698737006874 Walker A motif; other site 698737006875 ATP binding site [chemical binding]; other site 698737006876 Walker B motif; other site 698737006877 arginine finger; other site 698737006878 UvrB/uvrC motif; Region: UVR; pfam02151 698737006879 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698737006880 Walker A motif; other site 698737006881 ATP binding site [chemical binding]; other site 698737006882 Walker B motif; other site 698737006883 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 698737006884 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 698737006885 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 698737006886 ADP binding site [chemical binding]; other site 698737006887 phosphagen binding site; other site 698737006888 substrate specificity loop; other site 698737006889 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 698737006890 UvrB/uvrC motif; Region: UVR; pfam02151 698737006891 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 698737006892 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 698737006893 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 698737006894 Nucleoside recognition; Region: Gate; cl00486 698737006895 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 698737006896 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 698737006897 predicted active site [active] 698737006898 catalytic triad [active] 698737006899 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 698737006900 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 698737006901 active site 698737006902 multimer interface [polypeptide binding]; other site 698737006903 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 698737006904 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698737006905 DNA-binding site [nucleotide binding]; DNA binding site 698737006906 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698737006907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737006908 homodimer interface [polypeptide binding]; other site 698737006909 catalytic residue [active] 698737006910 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 698737006911 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 698737006912 dimer interface [polypeptide binding]; other site 698737006913 putative anticodon binding site; other site 698737006914 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 698737006915 motif 1; other site 698737006916 active site 698737006917 motif 2; other site 698737006918 motif 3; other site 698737006919 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 698737006920 catalytic center binding site [active] 698737006921 ATP binding site [chemical binding]; other site 698737006922 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 698737006923 homooctamer interface [polypeptide binding]; other site 698737006924 active site 698737006925 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 698737006926 dihydropteroate synthase; Region: DHPS; TIGR01496 698737006927 substrate binding pocket [chemical binding]; other site 698737006928 dimer interface [polypeptide binding]; other site 698737006929 inhibitor binding site; inhibition site 698737006930 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 698737006931 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 698737006932 dimer interface [polypeptide binding]; other site 698737006933 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737006934 catalytic residue [active] 698737006935 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 698737006936 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 698737006937 dimerization interface [polypeptide binding]; other site 698737006938 domain crossover interface; other site 698737006939 redox-dependent activation switch; other site 698737006940 FtsH Extracellular; Region: FtsH_ext; pfam06480 698737006941 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 698737006942 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698737006943 Walker A motif; other site 698737006944 ATP binding site [chemical binding]; other site 698737006945 Walker B motif; other site 698737006946 arginine finger; other site 698737006947 Peptidase family M41; Region: Peptidase_M41; pfam01434 698737006948 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698737006949 active site 698737006950 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 698737006951 Ligand Binding Site [chemical binding]; other site 698737006952 B3/4 domain; Region: B3_4; cl11458 698737006953 hypothetical protein; Provisional; Region: PRK08582 698737006954 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 698737006955 RNA binding site [nucleotide binding]; other site 698737006956 Septum formation initiator; Region: DivIC; cl11433 698737006957 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 698737006958 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 698737006959 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 698737006960 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 698737006961 MatE; Region: MatE; cl10513 698737006962 integral membrane protein MviN; Region: mviN; TIGR01695 698737006963 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 698737006964 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 698737006965 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698737006966 ATP binding site [chemical binding]; other site 698737006967 putative Mg++ binding site [ion binding]; other site 698737006968 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698737006969 nucleotide binding region [chemical binding]; other site 698737006970 ATP-binding site [chemical binding]; other site 698737006971 TRCF domain; Region: TRCF; cl04088 698737006972 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 698737006973 putative active site [active] 698737006974 catalytic residue [active] 698737006975 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 698737006976 5S rRNA interface [nucleotide binding]; other site 698737006977 CTC domain interface [polypeptide binding]; other site 698737006978 L16 interface [polypeptide binding]; other site 698737006979 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 698737006980 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 698737006981 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698737006982 active site 698737006983 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 698737006984 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 698737006985 Substrate binding site; other site 698737006986 Mg++ binding site; other site 698737006987 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 698737006988 active site 698737006989 substrate binding site [chemical binding]; other site 698737006990 CoA binding site [chemical binding]; other site 698737006991 SpoVG; Region: SpoVG; cl00915 698737006992 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 698737006993 homotrimer interaction site [polypeptide binding]; other site 698737006994 putative active site [active] 698737006995 pur operon repressor; Provisional; Region: PRK09213 698737006996 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 698737006997 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 698737006998 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 698737006999 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 698737007000 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 698737007001 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 698737007002 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737007003 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 698737007004 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 698737007005 putative active site [active] 698737007006 putative metal binding site [ion binding]; other site 698737007007 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 698737007008 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 698737007009 active site 698737007010 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 698737007011 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 698737007012 active site 698737007013 HIGH motif; other site 698737007014 KMSKS motif; other site 698737007015 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 698737007016 tRNA binding surface [nucleotide binding]; other site 698737007017 anticodon binding site; other site 698737007018 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 698737007019 dimer interface [polypeptide binding]; other site 698737007020 putative tRNA-binding site [nucleotide binding]; other site 698737007021 Predicted methyltransferases [General function prediction only]; Region: COG0313 698737007022 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 698737007023 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 698737007024 GIY-YIG motif/motif A; other site 698737007025 putative active site [active] 698737007026 putative metal binding site [ion binding]; other site 698737007027 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 698737007028 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737007029 TSC-22/dip/bun family; Region: TSC22; cl01853 698737007030 PSP1 C-terminal conserved region; Region: PSP1; cl00770 698737007031 DNA polymerase III subunit delta'; Validated; Region: PRK08058 698737007032 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737007033 Nitrogen regulatory protein P-II; Region: P-II; cl00412 698737007034 thymidylate kinase; Validated; Region: tmk; PRK00698 698737007035 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 698737007036 TMP-binding site; other site 698737007037 ATP-binding site [chemical binding]; other site 698737007038 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 698737007039 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698737007040 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698737007041 catalytic residue [active] 698737007042 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 698737007043 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 698737007044 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698737007045 Coenzyme A binding pocket [chemical binding]; other site 698737007046 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 698737007047 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 698737007048 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 698737007049 Transposase; Region: DDE_Tnp_ISL3; pfam01610 698737007050 recombination protein RecR; Reviewed; Region: recR; PRK00076 698737007051 Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278 698737007052 RecR protein; Region: RecR; pfam02132 698737007053 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 698737007054 putative active site [active] 698737007055 putative metal-binding site [ion binding]; other site 698737007056 tetramer interface [polypeptide binding]; other site 698737007057 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 698737007058 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 698737007059 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698737007060 Walker A motif; other site 698737007061 ATP binding site [chemical binding]; other site 698737007062 Walker B motif; other site 698737007063 arginine finger; other site 698737007064 Predicted acetyltransferase [General function prediction only]; Region: COG3153 698737007065 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698737007066 Coenzyme A binding pocket [chemical binding]; other site 698737007067 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698737007068 DNA-binding site [nucleotide binding]; DNA binding site 698737007069 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 698737007070 UTRA domain; Region: UTRA; cl01230 698737007071 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 698737007072 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 698737007073 Ca binding site [ion binding]; other site 698737007074 active site 698737007075 catalytic site [active] 698737007076 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 698737007077 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 698737007078 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 698737007079 active site turn [active] 698737007080 phosphorylation site [posttranslational modification] 698737007081 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 698737007082 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 698737007083 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737007084 NAD(P) binding site [chemical binding]; other site 698737007085 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 698737007086 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 698737007087 active site 698737007088 dimer interface [polypeptide binding]; other site 698737007089 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 698737007090 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 698737007091 active site 698737007092 FMN binding site [chemical binding]; other site 698737007093 substrate binding site [chemical binding]; other site 698737007094 3Fe-4S cluster binding site [ion binding]; other site 698737007095 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 698737007096 domain interface; other site 698737007097 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698737007098 Helix-turn-helix domains; Region: HTH; cl00088 698737007099 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698737007100 dimerization interface [polypeptide binding]; other site 698737007101 YibE/F-like protein; Region: YibE_F; cl02259 698737007102 YibE/F-like protein; Region: YibE_F; cl02259 698737007103 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 698737007104 nudix motif; other site 698737007105 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 698737007106 putative peptidoglycan binding site; other site 698737007107 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 698737007108 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 698737007109 putative peptidoglycan binding site; other site 698737007110 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 698737007111 putative peptidoglycan binding site; other site 698737007112 NlpC/P60 family; Region: NLPC_P60; cl11438 698737007113 NMT1-like family; Region: NMT1_2; cl15260 698737007114 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737007115 dimer interface [polypeptide binding]; other site 698737007116 conserved gate region; other site 698737007117 ABC-ATPase subunit interface; other site 698737007118 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 698737007119 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 698737007120 Walker A/P-loop; other site 698737007121 ATP binding site [chemical binding]; other site 698737007122 Q-loop/lid; other site 698737007123 ABC transporter signature motif; other site 698737007124 Walker B; other site 698737007125 D-loop; other site 698737007126 H-loop/switch region; other site 698737007127 NIL domain; Region: NIL; cl09633 698737007128 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 698737007129 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737007130 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698737007131 Walker A/P-loop; other site 698737007132 ATP binding site [chemical binding]; other site 698737007133 Q-loop/lid; other site 698737007134 ABC transporter signature motif; other site 698737007135 Walker B; other site 698737007136 D-loop; other site 698737007137 H-loop/switch region; other site 698737007138 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698737007139 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 698737007140 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737007141 Walker A/P-loop; other site 698737007142 ATP binding site [chemical binding]; other site 698737007143 Q-loop/lid; other site 698737007144 ABC transporter signature motif; other site 698737007145 Walker B; other site 698737007146 D-loop; other site 698737007147 H-loop/switch region; other site 698737007148 cystathionine beta-lyase; Provisional; Region: PRK07671 698737007149 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 698737007150 homodimer interface [polypeptide binding]; other site 698737007151 substrate-cofactor binding pocket; other site 698737007152 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737007153 catalytic residue [active] 698737007154 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 698737007155 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 698737007156 dimer interface [polypeptide binding]; other site 698737007157 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737007158 catalytic residue [active] 698737007159 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 698737007160 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 698737007161 Esterase/lipase [General function prediction only]; Region: COG1647 698737007162 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 698737007163 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 698737007164 active site 698737007165 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 698737007166 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 698737007167 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 698737007168 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 698737007169 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 698737007170 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 698737007171 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737007172 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 698737007173 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 698737007174 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698737007175 Helix-turn-helix domains; Region: HTH; cl00088 698737007176 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 698737007177 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 698737007178 active site 698737007179 nucleophile elbow; other site 698737007180 GMP synthase; Reviewed; Region: guaA; PRK00074 698737007181 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 698737007182 AMP/PPi binding site [chemical binding]; other site 698737007183 candidate oxyanion hole; other site 698737007184 catalytic triad [active] 698737007185 potential glutamine specificity residues [chemical binding]; other site 698737007186 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 698737007187 ATP Binding subdomain [chemical binding]; other site 698737007188 Ligand Binding sites [chemical binding]; other site 698737007189 Dimerization subdomain; other site 698737007190 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 698737007191 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 698737007192 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 698737007193 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 698737007194 active site 698737007195 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 698737007196 xanthine permease; Region: pbuX; TIGR03173 698737007197 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 698737007198 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698737007199 active site 698737007200 Heat induced stress protein YflT; Region: YflT; pfam11181 698737007201 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 698737007202 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 698737007203 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 698737007204 dimer interface [polypeptide binding]; other site 698737007205 FMN binding site [chemical binding]; other site 698737007206 NADPH bind site [chemical binding]; other site 698737007207 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 698737007208 peroxiredoxin; Region: AhpC; TIGR03137 698737007209 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 698737007210 dimer interface [polypeptide binding]; other site 698737007211 decamer (pentamer of dimers) interface [polypeptide binding]; other site 698737007212 catalytic triad [active] 698737007213 peroxidatic and resolving cysteines [active] 698737007214 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 698737007215 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 698737007216 catalytic residue [active] 698737007217 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 698737007218 catalytic residues [active] 698737007219 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698737007220 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698737007221 catalytic core [active] 698737007222 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 698737007223 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 698737007224 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 698737007225 dimer interface [polypeptide binding]; other site 698737007226 ssDNA binding site [nucleotide binding]; other site 698737007227 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698737007228 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 698737007229 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 698737007230 active site 698737007231 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 698737007232 GTP-binding protein YchF; Reviewed; Region: PRK09601 698737007233 YchF GTPase; Region: YchF; cd01900 698737007234 G1 box; other site 698737007235 GTP/Mg2+ binding site [chemical binding]; other site 698737007236 Switch I region; other site 698737007237 G2 box; other site 698737007238 Switch II region; other site 698737007239 G3 box; other site 698737007240 G4 box; other site 698737007241 G5 box; other site 698737007242 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 698737007243 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 698737007244 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698737007245 ParB-like partition proteins; Region: parB_part; TIGR00180 698737007246 ParB-like nuclease domain; Region: ParBc; cl02129 698737007247 cystathionine gamma-synthase; Reviewed; Region: PRK08247 698737007248 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698737007249 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698737007250 catalytic residue [active] 698737007251 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 698737007252 cystathionine beta-lyase; Provisional; Region: PRK08064 698737007253 homodimer interface [polypeptide binding]; other site 698737007254 substrate-cofactor binding pocket; other site 698737007255 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737007256 catalytic residue [active] 698737007257 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 698737007258 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 698737007259 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 698737007260 FAD binding site [chemical binding]; other site 698737007261 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 698737007262 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 698737007263 THF binding site; other site 698737007264 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 698737007265 substrate binding site [chemical binding]; other site 698737007266 THF binding site; other site 698737007267 zinc-binding site [ion binding]; other site 698737007268 Putative cyclase; Region: Cyclase; cl00814 698737007269 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 698737007270 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 698737007271 ferrous iron transporter FeoB; Region: feoB; TIGR00437 698737007272 Nucleoside recognition; Region: Gate; cl00486 698737007273 Nucleoside recognition; Region: Gate; cl00486 698737007274 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 698737007275 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737007276 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 698737007277 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698737007278 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698737007279 FtsX-like permease family; Region: FtsX; cl15850 698737007280 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698737007281 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 698737007282 Walker A/P-loop; other site 698737007283 ATP binding site [chemical binding]; other site 698737007284 Q-loop/lid; other site 698737007285 ABC transporter signature motif; other site 698737007286 Walker B; other site 698737007287 D-loop; other site 698737007288 H-loop/switch region; other site 698737007289 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698737007290 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 698737007291 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 698737007292 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698737007293 active site 698737007294 metal binding site [ion binding]; metal-binding site 698737007295 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 698737007296 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698737007297 dimer interface [polypeptide binding]; other site 698737007298 phosphorylation site [posttranslational modification] 698737007299 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737007300 ATP binding site [chemical binding]; other site 698737007301 Mg2+ binding site [ion binding]; other site 698737007302 G-X-G motif; other site 698737007303 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698737007304 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737007305 Walker A/P-loop; other site 698737007306 ATP binding site [chemical binding]; other site 698737007307 Q-loop/lid; other site 698737007308 ABC transporter signature motif; other site 698737007309 Walker B; other site 698737007310 D-loop; other site 698737007311 H-loop/switch region; other site 698737007312 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698737007313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698737007314 active site 698737007315 phosphorylation site [posttranslational modification] 698737007316 intermolecular recognition site; other site 698737007317 dimerization interface [polypeptide binding]; other site 698737007318 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698737007319 DNA binding site [nucleotide binding] 698737007320 galactoside permease; Reviewed; Region: lacY; PRK09528 698737007321 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 698737007322 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 698737007323 substrate binding [chemical binding]; other site 698737007324 active site 698737007325 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 698737007326 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698737007327 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698737007328 DNA binding site [nucleotide binding] 698737007329 domain linker motif; other site 698737007330 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 698737007331 dimerization interface [polypeptide binding]; other site 698737007332 ligand binding site [chemical binding]; other site 698737007333 sodium binding site [ion binding]; other site 698737007334 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 698737007335 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 698737007336 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 698737007337 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 698737007338 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737007339 putative substrate translocation pore; other site 698737007340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737007341 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 698737007342 Catalytic site [active] 698737007343 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698737007344 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 698737007345 Walker A/P-loop; other site 698737007346 ATP binding site [chemical binding]; other site 698737007347 Q-loop/lid; other site 698737007348 ABC transporter signature motif; other site 698737007349 Walker B; other site 698737007350 D-loop; other site 698737007351 H-loop/switch region; other site 698737007352 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698737007353 non-specific DNA binding site [nucleotide binding]; other site 698737007354 salt bridge; other site 698737007355 sequence-specific DNA binding site [nucleotide binding]; other site 698737007356 NMT1-like family; Region: NMT1_2; cl15260 698737007357 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 698737007358 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737007359 NAD(P) binding site [chemical binding]; other site 698737007360 active site 698737007361 polyol permease family; Region: 2A0118; TIGR00897 698737007362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737007363 putative substrate translocation pore; other site 698737007364 L-ribulokinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 698737007365 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 698737007366 putative N- and C-terminal domain interface [polypeptide binding]; other site 698737007367 putative active site [active] 698737007368 putative MgATP binding site [chemical binding]; other site 698737007369 catalytic site [active] 698737007370 metal binding site [ion binding]; metal-binding site 698737007371 putative carbohydrate binding site [chemical binding]; other site 698737007372 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 698737007373 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 698737007374 inhibitor binding site; inhibition site 698737007375 catalytic Zn binding site [ion binding]; other site 698737007376 structural Zn binding site [ion binding]; other site 698737007377 NADP binding site [chemical binding]; other site 698737007378 tetramer interface [polypeptide binding]; other site 698737007379 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698737007380 Helix-turn-helix domains; Region: HTH; cl00088 698737007381 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 698737007382 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 698737007383 ParB-like nuclease domain; Region: ParBc; cl02129 698737007384 ParB-like partition proteins; Region: parB_part; TIGR00180 698737007385 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 698737007386 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 698737007387 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737007388 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 698737007389 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 698737007390 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 698737007391 trmE is a tRNA modification GTPase; Region: trmE; cd04164 698737007392 G1 box; other site 698737007393 GTP/Mg2+ binding site [chemical binding]; other site 698737007394 Switch I region; other site 698737007395 G2 box; other site 698737007396 Switch II region; other site 698737007397 G3 box; other site 698737007398 G4 box; other site 698737007399 G5 box; other site 698737007400 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 698737007401 Ribonuclease P; Region: Ribonuclease_P; cl00457 698737007402 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 698737007403 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 698737007404 DnaA N-terminal domain; Region: DnaA_N; pfam11638 698737007405 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698737007406 Walker A motif; other site 698737007407 ATP binding site [chemical binding]; other site 698737007408 Walker B motif; other site 698737007409 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737007410 arginine finger; other site 698737007411 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 698737007412 DnaA box-binding interface [nucleotide binding]; other site 698737007413 DNA polymerase III subunit beta; Validated; Region: PRK05643 698737007414 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 698737007415 putative DNA binding surface [nucleotide binding]; other site 698737007416 dimer interface [polypeptide binding]; other site 698737007417 beta-clamp/clamp loader binding surface; other site 698737007418 beta-clamp/translesion DNA polymerase binding surface; other site 698737007419 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 698737007420 recombination protein F; Reviewed; Region: recF; PRK00064 698737007421 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 698737007422 Walker A/P-loop; other site 698737007423 ATP binding site [chemical binding]; other site 698737007424 Q-loop/lid; other site 698737007425 ABC transporter signature motif; other site 698737007426 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698737007427 ABC transporter signature motif; other site 698737007428 Walker B; other site 698737007429 D-loop; other site 698737007430 H-loop/switch region; other site 698737007431 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 698737007432 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737007433 Mg2+ binding site [ion binding]; other site 698737007434 G-X-G motif; other site 698737007435 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 698737007436 anchoring element; other site 698737007437 dimer interface [polypeptide binding]; other site 698737007438 ATP binding site [chemical binding]; other site 698737007439 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 698737007440 active site 698737007441 putative metal-binding site [ion binding]; other site 698737007442 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 698737007443 DNA gyrase subunit A; Validated; Region: PRK05560 698737007444 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 698737007445 CAP-like domain; other site 698737007446 active site 698737007447 primary dimer interface [polypeptide binding]; other site 698737007448 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698737007449 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698737007450 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698737007451 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698737007452 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698737007453 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698737007454 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 698737007455 putative substrate binding site [chemical binding]; other site 698737007456 putative ATP binding site [chemical binding]; other site 698737007457 seryl-tRNA synthetase; Provisional; Region: PRK05431 698737007458 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 698737007459 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 698737007460 dimer interface [polypeptide binding]; other site 698737007461 active site 698737007462 motif 1; other site 698737007463 motif 2; other site 698737007464 motif 3; other site 698737007465 AzlC protein; Region: AzlC; cl00570 698737007466 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 698737007467 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 698737007468 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 698737007469 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 698737007470 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 698737007471 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 698737007472 DHH family; Region: DHH; pfam01368 698737007473 DHHA1 domain; Region: DHHA1; pfam02272 698737007474 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 698737007475 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 698737007476 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 698737007477 replicative DNA helicase; Region: DnaB; TIGR00665 698737007478 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 698737007479 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 698737007480 Walker A motif; other site 698737007481 ATP binding site [chemical binding]; other site 698737007482 Walker B motif; other site 698737007483 DNA binding loops [nucleotide binding] 698737007484 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 698737007485 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 698737007486 GDP-binding site [chemical binding]; other site 698737007487 ACT binding site; other site 698737007488 IMP binding site; other site 698737007489 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698737007490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698737007491 active site 698737007492 phosphorylation site [posttranslational modification] 698737007493 intermolecular recognition site; other site 698737007494 dimerization interface [polypeptide binding]; other site 698737007495 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698737007496 DNA binding site [nucleotide binding] 698737007497 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 698737007498 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698737007499 dimerization interface [polypeptide binding]; other site 698737007500 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698737007501 putative active site [active] 698737007502 heme pocket [chemical binding]; other site 698737007503 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698737007504 dimer interface [polypeptide binding]; other site 698737007505 phosphorylation site [posttranslational modification] 698737007506 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737007507 ATP binding site [chemical binding]; other site 698737007508 Mg2+ binding site [ion binding]; other site 698737007509 G-X-G motif; other site 698737007510 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 698737007511 YycH protein; Region: YycH; pfam07435 698737007512 YycH protein; Region: YycI; cl02015 698737007513 OpgC protein; Region: OpgC_C; cl00792 698737007514 Acyltransferase family; Region: Acyl_transf_3; pfam01757 698737007515 Putative catalytic polysaccharide deacetylase domain of bacterial intercellular adhesion protein IcaB and similar proteins; Region: CE4_IcaB_5s; cd10965 698737007516 putative active site [active] 698737007517 putative metal binding site [ion binding]; other site 698737007518 intracellular adhesion protein D; Region: PIA_icaD; TIGR03932 698737007519 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 698737007520 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 698737007521 DXD motif; other site 698737007522 potential frameshift: common BLAST hit: gi|165976517|ref|YP_001652110.1| N-acetyl-beta-hexosaminidase 698737007523 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 698737007524 active site 698737007525 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 698737007526 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446