-- dump date 20120504_162430 -- class Genbank::misc_feature -- table misc_feature_note -- id note 937773000001 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 937773000002 Ribonuclease P; Region: Ribonuclease_P; cl00457 937773000003 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 937773000004 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 937773000005 trmE is a tRNA modification GTPase; Region: trmE; cd04164 937773000006 G1 box; other site 937773000007 GTP/Mg2+ binding site [chemical binding]; other site 937773000008 Switch I region; other site 937773000009 G2 box; other site 937773000010 Switch II region; other site 937773000011 G3 box; other site 937773000012 G4 box; other site 937773000013 G5 box; other site 937773000014 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 937773000015 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 937773000016 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773000017 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 937773000018 Methyltransferase domain; Region: Methyltransf_31; pfam13847 937773000019 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 937773000020 S-adenosylmethionine binding site [chemical binding]; other site 937773000021 ParB-like partition proteins; Region: parB_part; TIGR00180 937773000022 ParB-like nuclease domain; Region: ParBc; cl02129 937773000023 Predicted esterase [General function prediction only]; Region: COG0400 937773000024 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 937773000025 nucleophilic elbow; other site 937773000026 catalytic triad; other site 937773000027 Flavin Reductases; Region: FlaRed; cl00801 937773000028 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 937773000029 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 937773000030 Zn binding site [ion binding]; other site 937773000031 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 937773000032 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 937773000033 Zn binding site [ion binding]; other site 937773000034 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 937773000035 Helix-turn-helix domains; Region: HTH; cl00088 937773000036 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 937773000037 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 937773000038 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 937773000039 dimer interface [polypeptide binding]; other site 937773000040 catalytic residues [active] 937773000041 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 937773000042 UreF; Region: UreF; pfam01730 937773000043 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773000044 UreD urease accessory protein; Region: UreD; cl00530 937773000045 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 937773000046 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 937773000047 THF binding site; other site 937773000048 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 937773000049 substrate binding site [chemical binding]; other site 937773000050 THF binding site; other site 937773000051 zinc-binding site [ion binding]; other site 937773000052 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 937773000053 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 937773000054 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 937773000055 FAD binding site [chemical binding]; other site 937773000056 cystathionine beta-lyase; Provisional; Region: PRK08064 937773000057 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 937773000058 homodimer interface [polypeptide binding]; other site 937773000059 substrate-cofactor binding pocket; other site 937773000060 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773000061 catalytic residue [active] 937773000062 cystathionine gamma-synthase; Reviewed; Region: PRK08247 937773000063 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 937773000064 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 937773000065 catalytic residue [active] 937773000066 ParB-like partition proteins; Region: parB_part; TIGR00180 937773000067 ParB-like nuclease domain; Region: ParBc; cl02129 937773000068 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 937773000069 Mechanosensitive ion channel; Region: MS_channel; pfam00924 937773000070 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 937773000071 GTP-binding protein YchF; Reviewed; Region: PRK09601 937773000072 YchF GTPase; Region: YchF; cd01900 937773000073 G1 box; other site 937773000074 GTP/Mg2+ binding site [chemical binding]; other site 937773000075 Switch I region; other site 937773000076 G2 box; other site 937773000077 Switch II region; other site 937773000078 G3 box; other site 937773000079 G4 box; other site 937773000080 G5 box; other site 937773000081 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 937773000082 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 937773000083 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 937773000084 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773000085 Walker A/P-loop; other site 937773000086 ATP binding site [chemical binding]; other site 937773000087 Q-loop/lid; other site 937773000088 ABC transporter signature motif; other site 937773000089 Walker B; other site 937773000090 D-loop; other site 937773000091 H-loop/switch region; other site 937773000092 ABC-2 type transporter; Region: ABC2_membrane; cl11417 937773000093 B domain; Region: B; pfam02216 937773000094 B domain; Region: B; pfam02216 937773000095 C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621 937773000096 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 937773000097 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 937773000098 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 937773000099 dimer interface [polypeptide binding]; other site 937773000100 ssDNA binding site [nucleotide binding]; other site 937773000101 tetramer (dimer of dimers) interface [polypeptide binding]; other site 937773000102 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 937773000103 Abi-like protein; Region: Abi_2; cl01988 937773000104 hydroperoxidase II; Provisional; Region: katE; PRK11249 937773000105 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 937773000106 heme binding pocket [chemical binding]; other site 937773000107 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 937773000108 conserved cys residue [active] 937773000109 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 937773000110 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 937773000111 active site 937773000112 NMT1-like family; Region: NMT1_2; cl15260 937773000113 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 937773000114 dimer interface [polypeptide binding]; other site 937773000115 conserved gate region; other site 937773000116 ABC-ATPase subunit interface; other site 937773000117 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 937773000118 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 937773000119 Walker A/P-loop; other site 937773000120 ATP binding site [chemical binding]; other site 937773000121 Q-loop/lid; other site 937773000122 ABC transporter signature motif; other site 937773000123 Walker B; other site 937773000124 D-loop; other site 937773000125 H-loop/switch region; other site 937773000126 NIL domain; Region: NIL; cl09633 937773000127 Protein of unknown function (DUF419); Region: DUF419; cl15265 937773000128 biotin synthase; Validated; Region: PRK06256 937773000129 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 937773000130 FeS/SAM binding site; other site 937773000131 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 937773000132 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 937773000133 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 937773000134 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 937773000135 catalytic residue [active] 937773000136 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 937773000137 catalytic residues [active] 937773000138 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 937773000139 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 937773000140 peroxiredoxin; Region: AhpC; TIGR03137 937773000141 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 937773000142 dimer interface [polypeptide binding]; other site 937773000143 decamer (pentamer of dimers) interface [polypeptide binding]; other site 937773000144 catalytic triad [active] 937773000145 peroxidatic and resolving cysteines [active] 937773000146 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 937773000147 dimer interface [polypeptide binding]; other site 937773000148 FMN binding site [chemical binding]; other site 937773000149 NADPH bind site [chemical binding]; other site 937773000150 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 937773000151 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 937773000152 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 937773000153 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 937773000154 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 937773000155 Walker A/P-loop; other site 937773000156 ATP binding site [chemical binding]; other site 937773000157 Q-loop/lid; other site 937773000158 ABC transporter signature motif; other site 937773000159 Walker B; other site 937773000160 D-loop; other site 937773000161 H-loop/switch region; other site 937773000162 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 937773000163 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 937773000164 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773000165 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 937773000166 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773000167 Heat induced stress protein YflT; Region: YflT; pfam11181 937773000168 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 937773000169 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 937773000170 active site 937773000171 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 937773000172 xanthine permease; Region: pbuX; TIGR03173 937773000173 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 937773000174 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 937773000175 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 937773000176 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 937773000177 active site 937773000178 GMP synthase; Reviewed; Region: guaA; PRK00074 937773000179 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 937773000180 AMP/PPi binding site [chemical binding]; other site 937773000181 candidate oxyanion hole; other site 937773000182 catalytic triad [active] 937773000183 potential glutamine specificity residues [chemical binding]; other site 937773000184 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 937773000185 ATP Binding subdomain [chemical binding]; other site 937773000186 Ligand Binding sites [chemical binding]; other site 937773000187 Dimerization subdomain; other site 937773000188 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 937773000189 Int/Topo IB signature motif; other site 937773000190 Terminase small subunit; Region: Terminase_2; cl01513 937773000191 potential frameshift: common BLAST hit: gi|227811479|ref|YP_002811490.1| Abi-like protein 937773000192 Abi-like protein; Region: Abi_2; cl01988 937773000193 Abi-like protein; Region: Abi_2; cl01988 937773000194 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 937773000195 gating phenylalanine in ion channel; other site 937773000196 Staphylococcal nuclease homologues; Region: SNc; smart00318 937773000197 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 937773000198 Catalytic site; other site 937773000199 Excalibur calcium-binding domain; Region: Excalibur; cl05460 937773000200 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 937773000201 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 937773000202 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 937773000203 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 937773000204 Amino acid permease; Region: AA_permease; pfam00324 937773000205 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 937773000206 Peptidase C26; Region: Peptidase_C26; pfam07722 937773000207 catalytic triad [active] 937773000208 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 937773000209 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773000210 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 937773000211 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 937773000212 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 937773000213 substrate binding site [chemical binding]; other site 937773000214 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 937773000215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 937773000216 dimer interface [polypeptide binding]; other site 937773000217 conserved gate region; other site 937773000218 putative PBP binding loops; other site 937773000219 ABC-ATPase subunit interface; other site 937773000220 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 937773000221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 937773000222 dimer interface [polypeptide binding]; other site 937773000223 conserved gate region; other site 937773000224 putative PBP binding loops; other site 937773000225 ABC-ATPase subunit interface; other site 937773000226 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 937773000227 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 937773000228 Walker A/P-loop; other site 937773000229 ATP binding site [chemical binding]; other site 937773000230 Q-loop/lid; other site 937773000231 ABC transporter signature motif; other site 937773000232 Walker B; other site 937773000233 D-loop; other site 937773000234 H-loop/switch region; other site 937773000235 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 937773000236 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 937773000237 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 937773000238 Walker A/P-loop; other site 937773000239 ATP binding site [chemical binding]; other site 937773000240 Q-loop/lid; other site 937773000241 ABC transporter signature motif; other site 937773000242 Walker B; other site 937773000243 D-loop; other site 937773000244 H-loop/switch region; other site 937773000245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773000246 Major Facilitator Superfamily; Region: MFS_1; pfam07690 937773000247 putative substrate translocation pore; other site 937773000248 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 937773000249 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 937773000250 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773000251 putative substrate translocation pore; other site 937773000252 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 937773000253 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 937773000254 putative homotetramer interface [polypeptide binding]; other site 937773000255 putative homodimer interface [polypeptide binding]; other site 937773000256 putative metal binding site [ion binding]; other site 937773000257 putative homodimer-homodimer interface [polypeptide binding]; other site 937773000258 putative allosteric switch controlling residues; other site 937773000259 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 937773000260 active site residue [active] 937773000261 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 937773000262 CPxP motif; other site 937773000263 DsrE/DsrF-like family; Region: DrsE; cl00672 937773000264 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 937773000265 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 937773000266 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 937773000267 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 937773000268 active site residue [active] 937773000269 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 937773000270 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 937773000271 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 937773000272 putative active site [active] 937773000273 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 937773000274 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 937773000275 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 937773000276 active site turn [active] 937773000277 phosphorylation site [posttranslational modification] 937773000278 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 937773000279 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 937773000280 NAD binding site [chemical binding]; other site 937773000281 sugar binding site [chemical binding]; other site 937773000282 divalent metal binding site [ion binding]; other site 937773000283 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 937773000284 dimer interface [polypeptide binding]; other site 937773000285 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 937773000286 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773000287 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 937773000288 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 937773000289 oligomerization interface [polypeptide binding]; other site 937773000290 active site 937773000291 metal binding site [ion binding]; metal-binding site 937773000292 pantoate--beta-alanine ligase; Region: panC; TIGR00018 937773000293 Pantoate-beta-alanine ligase; Region: PanC; cd00560 937773000294 active site 937773000295 ATP-binding site [chemical binding]; other site 937773000296 pantoate-binding site; other site 937773000297 HXXH motif; other site 937773000298 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 937773000299 tetramerization interface [polypeptide binding]; other site 937773000300 active site 937773000301 superantigen-like protein; Reviewed; Region: PRK13036 937773000302 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 937773000303 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 937773000304 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 937773000305 ribonuclease E; Reviewed; Region: rne; PRK10811 937773000306 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773000307 pyruvate phosphate dikinase; Provisional; Region: PRK09279 937773000308 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 937773000309 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 937773000310 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 937773000311 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 937773000312 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 937773000313 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 937773000314 K+-transporting ATPase, c chain; Region: KdpC; cl00944 937773000315 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 937773000316 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 937773000317 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 937773000318 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 937773000319 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 937773000320 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 937773000321 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 937773000322 Ligand Binding Site [chemical binding]; other site 937773000323 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 937773000324 dimer interface [polypeptide binding]; other site 937773000325 phosphorylation site [posttranslational modification] 937773000326 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 937773000327 ATP binding site [chemical binding]; other site 937773000328 Mg2+ binding site [ion binding]; other site 937773000329 G-X-G motif; other site 937773000330 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 937773000331 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 937773000332 active site 937773000333 phosphorylation site [posttranslational modification] 937773000334 intermolecular recognition site; other site 937773000335 dimerization interface [polypeptide binding]; other site 937773000336 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 937773000337 DNA binding site [nucleotide binding] 937773000338 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 937773000339 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 937773000340 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 937773000341 substrate binding pocket [chemical binding]; other site 937773000342 catalytic triad [active] 937773000343 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 937773000344 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 937773000345 dimer interface [polypeptide binding]; other site 937773000346 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773000347 catalytic residue [active] 937773000348 cystathionine beta-lyase; Provisional; Region: PRK07671 937773000349 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 937773000350 homodimer interface [polypeptide binding]; other site 937773000351 substrate-cofactor binding pocket; other site 937773000352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773000353 catalytic residue [active] 937773000354 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 937773000355 putative peptidoglycan binding site; other site 937773000356 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 937773000357 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 937773000358 putative peptidoglycan binding site; other site 937773000359 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 937773000360 putative peptidoglycan binding site; other site 937773000361 NlpC/P60 family; Region: NLPC_P60; cl11438 937773000362 Putative integral membrane protein (DUF2391); Region: DUF2391; cl01935 937773000363 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 937773000364 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 937773000365 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 937773000366 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 937773000367 Walker A/P-loop; other site 937773000368 ATP binding site [chemical binding]; other site 937773000369 Q-loop/lid; other site 937773000370 ABC transporter signature motif; other site 937773000371 Walker B; other site 937773000372 D-loop; other site 937773000373 H-loop/switch region; other site 937773000374 potential frameshift: common BLAST hit: gi|311070255|ref|YP_003975178.1| antilisterial bacteriocin (subtilosin) production enzyme 937773000375 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 937773000376 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 937773000377 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 937773000378 FeS/SAM binding site; other site 937773000379 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 937773000380 Helix-turn-helix domains; Region: HTH; cl00088 937773000381 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 937773000382 Transposase domain (DUF772); Region: DUF772; cl15789 937773000383 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 937773000384 AAA domain; Region: AAA_21; pfam13304 937773000385 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773000386 ABC transporter signature motif; other site 937773000387 Walker B; other site 937773000388 D-loop; other site 937773000389 H-loop/switch region; other site 937773000390 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 937773000391 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773000392 Walker A/P-loop; other site 937773000393 ATP binding site [chemical binding]; other site 937773000394 Q-loop/lid; other site 937773000395 ABC transporter signature motif; other site 937773000396 Walker B; other site 937773000397 D-loop; other site 937773000398 H-loop/switch region; other site 937773000399 YibE/F-like protein; Region: YibE_F; cl02259 937773000400 YibE/F-like protein; Region: YibE_F; cl02259 937773000401 Transcriptional regulator [Transcription]; Region: LysR; COG0583 937773000402 Helix-turn-helix domains; Region: HTH; cl00088 937773000403 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 937773000404 dimerization interface [polypeptide binding]; other site 937773000405 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 937773000406 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 937773000407 active site 937773000408 dimer interface [polypeptide binding]; other site 937773000409 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 937773000410 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 937773000411 active site 937773000412 FMN binding site [chemical binding]; other site 937773000413 substrate binding site [chemical binding]; other site 937773000414 3Fe-4S cluster binding site [ion binding]; other site 937773000415 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 937773000416 domain interface; other site 937773000417 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 937773000418 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 937773000419 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 937773000420 active site turn [active] 937773000421 phosphorylation site [posttranslational modification] 937773000422 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 937773000423 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 937773000424 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 937773000425 Ca binding site [ion binding]; other site 937773000426 active site 937773000427 catalytic site [active] 937773000428 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 937773000429 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 937773000430 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 937773000431 DNA-binding site [nucleotide binding]; DNA binding site 937773000432 UTRA domain; Region: UTRA; cl01230 937773000433 Predicted acetyltransferase [General function prediction only]; Region: COG3153 937773000434 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 937773000435 Coenzyme A binding pocket [chemical binding]; other site 937773000436 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 937773000437 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 937773000438 Walker A motif; other site 937773000439 ATP binding site [chemical binding]; other site 937773000440 Walker B motif; other site 937773000441 arginine finger; other site 937773000442 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 937773000443 recombination protein RecR; Reviewed; Region: recR; PRK00076 937773000444 Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278 937773000445 RecR protein; Region: RecR; pfam02132 937773000446 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 937773000447 putative active site [active] 937773000448 putative metal-binding site [ion binding]; other site 937773000449 tetramer interface [polypeptide binding]; other site 937773000450 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 937773000451 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 937773000452 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 937773000453 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 937773000454 catalytic residue [active] 937773000455 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 937773000456 thymidylate kinase; Validated; Region: tmk; PRK00698 937773000457 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 937773000458 TMP-binding site; other site 937773000459 ATP-binding site [chemical binding]; other site 937773000460 Nitrogen regulatory protein P-II; Region: P-II; cl00412 937773000461 DNA polymerase III subunit delta'; Validated; Region: PRK08058 937773000462 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773000463 PSP1 C-terminal conserved region; Region: PSP1; cl00770 937773000464 TSC-22/dip/bun family; Region: TSC22; cl01853 937773000465 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 937773000466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 937773000467 S-adenosylmethionine binding site [chemical binding]; other site 937773000468 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 937773000469 GIY-YIG motif/motif A; other site 937773000470 putative active site [active] 937773000471 putative metal binding site [ion binding]; other site 937773000472 Predicted methyltransferases [General function prediction only]; Region: COG0313 937773000473 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 937773000474 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 937773000475 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 937773000476 active site 937773000477 HIGH motif; other site 937773000478 KMSKS motif; other site 937773000479 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 937773000480 tRNA binding surface [nucleotide binding]; other site 937773000481 anticodon binding site; other site 937773000482 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 937773000483 dimer interface [polypeptide binding]; other site 937773000484 putative tRNA-binding site [nucleotide binding]; other site 937773000485 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 937773000486 active site 937773000487 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 937773000488 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 937773000489 putative active site [active] 937773000490 putative metal binding site [ion binding]; other site 937773000491 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 937773000492 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773000493 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 937773000494 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 937773000495 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 937773000496 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 937773000497 pur operon repressor; Provisional; Region: PRK09213 937773000498 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 937773000499 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 937773000500 active site 937773000501 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 937773000502 homotrimer interaction site [polypeptide binding]; other site 937773000503 putative active site [active] 937773000504 SpoVG; Region: SpoVG; cl00915 937773000505 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 937773000506 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 937773000507 Substrate binding site; other site 937773000508 Mg++ binding site; other site 937773000509 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 937773000510 active site 937773000511 substrate binding site [chemical binding]; other site 937773000512 CoA binding site [chemical binding]; other site 937773000513 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 937773000514 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 937773000515 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 937773000516 active site 937773000517 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 937773000518 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 937773000519 5S rRNA interface [nucleotide binding]; other site 937773000520 CTC domain interface [polypeptide binding]; other site 937773000521 L16 interface [polypeptide binding]; other site 937773000522 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 937773000523 putative active site [active] 937773000524 catalytic residue [active] 937773000525 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 937773000526 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 937773000527 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 937773000528 ATP binding site [chemical binding]; other site 937773000529 putative Mg++ binding site [ion binding]; other site 937773000530 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 937773000531 nucleotide binding region [chemical binding]; other site 937773000532 ATP-binding site [chemical binding]; other site 937773000533 TRCF domain; Region: TRCF; cl04088 937773000534 MatE; Region: MatE; cl10513 937773000535 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 937773000536 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 937773000537 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 937773000538 RNA binding surface [nucleotide binding]; other site 937773000539 Septum formation initiator; Region: DivIC; cl11433 937773000540 hypothetical protein; Provisional; Region: PRK08582 937773000541 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 937773000542 RNA binding site [nucleotide binding]; other site 937773000543 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 937773000544 Ligand Binding Site [chemical binding]; other site 937773000545 B3/4 domain; Region: B3_4; cl11458 937773000546 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 937773000547 active site 937773000548 FtsH Extracellular; Region: FtsH_ext; pfam06480 937773000549 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 937773000550 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 937773000551 Walker A motif; other site 937773000552 ATP binding site [chemical binding]; other site 937773000553 Walker B motif; other site 937773000554 arginine finger; other site 937773000555 Peptidase family M41; Region: Peptidase_M41; pfam01434 937773000556 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 937773000557 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 937773000558 dimerization interface [polypeptide binding]; other site 937773000559 domain crossover interface; other site 937773000560 redox-dependent activation switch; other site 937773000561 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 937773000562 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 937773000563 dimer interface [polypeptide binding]; other site 937773000564 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773000565 catalytic residue [active] 937773000566 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 937773000567 dihydropteroate synthase; Region: DHPS; TIGR01496 937773000568 substrate binding pocket [chemical binding]; other site 937773000569 dimer interface [polypeptide binding]; other site 937773000570 inhibitor binding site; inhibition site 937773000571 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 937773000572 homooctamer interface [polypeptide binding]; other site 937773000573 active site 937773000574 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 937773000575 catalytic center binding site [active] 937773000576 ATP binding site [chemical binding]; other site 937773000577 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 937773000578 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 937773000579 FMN binding site [chemical binding]; other site 937773000580 active site 937773000581 catalytic residues [active] 937773000582 substrate binding site [chemical binding]; other site 937773000583 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 937773000584 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 937773000585 dimer interface [polypeptide binding]; other site 937773000586 putative anticodon binding site; other site 937773000587 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 937773000588 motif 1; other site 937773000589 active site 937773000590 motif 2; other site 937773000591 motif 3; other site 937773000592 Predicted membrane protein [Function unknown]; Region: COG1289 937773000593 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 937773000594 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 937773000595 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 937773000596 DNA-binding site [nucleotide binding]; DNA binding site 937773000597 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 937773000598 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773000599 homodimer interface [polypeptide binding]; other site 937773000600 catalytic residue [active] 937773000601 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 937773000602 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 937773000603 active site 937773000604 multimer interface [polypeptide binding]; other site 937773000605 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13143 937773000606 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 937773000607 predicted active site [active] 937773000608 catalytic triad [active] 937773000609 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 937773000610 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 937773000611 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 937773000612 Nucleoside recognition; Region: Gate; cl00486 937773000613 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 937773000614 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 937773000615 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 937773000616 UvrB/uvrC motif; Region: UVR; pfam02151 937773000617 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 937773000618 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 937773000619 ADP binding site [chemical binding]; other site 937773000620 phosphagen binding site; other site 937773000621 substrate specificity loop; other site 937773000622 Clp protease ATP binding subunit; Region: clpC; CHL00095 937773000623 Clp amino terminal domain; Region: Clp_N; pfam02861 937773000624 Clp amino terminal domain; Region: Clp_N; pfam02861 937773000625 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 937773000626 Walker A motif; other site 937773000627 ATP binding site [chemical binding]; other site 937773000628 Walker B motif; other site 937773000629 arginine finger; other site 937773000630 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 937773000631 Walker A motif; other site 937773000632 ATP binding site [chemical binding]; other site 937773000633 Walker B motif; other site 937773000634 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 937773000635 bacteriocin biosynthesis cyclodehydratase, SagC family; Region: cyclo_dehy_ocin; TIGR03603 937773000636 YcaO-like family; Region: YcaO; pfam02624 937773000637 Uncharacterized conserved protein [Function unknown]; Region: COG1944; cl09146 937773000638 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 937773000639 putative FMN binding site [chemical binding]; other site 937773000640 NADPH bind site [chemical binding]; other site 937773000641 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 937773000642 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 937773000643 Walker A/P-loop; other site 937773000644 ATP binding site [chemical binding]; other site 937773000645 Q-loop/lid; other site 937773000646 ABC transporter signature motif; other site 937773000647 Walker B; other site 937773000648 D-loop; other site 937773000649 H-loop/switch region; other site 937773000650 DNA repair protein RadA; Provisional; Region: PRK11823 937773000651 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 937773000652 Walker A motif/ATP binding site; other site 937773000653 ATP binding site [chemical binding]; other site 937773000654 Walker B motif; other site 937773000655 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 937773000656 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 937773000657 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 937773000658 putative active site [active] 937773000659 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 937773000660 substrate binding site; other site 937773000661 dimer interface; other site 937773000662 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 937773000663 homotrimer interaction site [polypeptide binding]; other site 937773000664 zinc binding site [ion binding]; other site 937773000665 CDP-binding sites; other site 937773000666 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 937773000667 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 937773000668 active site 937773000669 HIGH motif; other site 937773000670 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 937773000671 active site 937773000672 KMSKS motif; other site 937773000673 serine O-acetyltransferase; Region: cysE; TIGR01172 937773000674 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 937773000675 trimer interface [polypeptide binding]; other site 937773000676 active site 937773000677 substrate binding site [chemical binding]; other site 937773000678 CoA binding site [chemical binding]; other site 937773000679 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 937773000680 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 937773000681 active site 937773000682 HIGH motif; other site 937773000683 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 937773000684 KMSKS motif; other site 937773000685 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 937773000686 tRNA binding surface [nucleotide binding]; other site 937773000687 anticodon binding site; other site 937773000688 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 937773000689 dimerization interface [polypeptide binding]; other site 937773000690 active site 937773000691 metal binding site [ion binding]; metal-binding site 937773000692 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 937773000693 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 937773000694 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 937773000695 YacP-like NYN domain; Region: NYN_YacP; cl01491 937773000696 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 937773000697 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 937773000698 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 937773000699 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 937773000700 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 937773000701 putative homodimer interface [polypeptide binding]; other site 937773000702 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 937773000703 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 937773000704 23S rRNA interface [nucleotide binding]; other site 937773000705 L7/L12 interface [polypeptide binding]; other site 937773000706 putative thiostrepton binding site; other site 937773000707 L25 interface [polypeptide binding]; other site 937773000708 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 937773000709 mRNA/rRNA interface [nucleotide binding]; other site 937773000710 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 937773000711 23S rRNA interface [nucleotide binding]; other site 937773000712 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 937773000713 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 937773000714 peripheral dimer interface [polypeptide binding]; other site 937773000715 core dimer interface [polypeptide binding]; other site 937773000716 L10 interface [polypeptide binding]; other site 937773000717 L11 interface [polypeptide binding]; other site 937773000718 putative EF-Tu interaction site [polypeptide binding]; other site 937773000719 putative EF-G interaction site [polypeptide binding]; other site 937773000720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 937773000721 S-adenosylmethionine binding site [chemical binding]; other site 937773000722 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 937773000723 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 937773000724 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 937773000725 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 937773000726 RPB12 interaction site [polypeptide binding]; other site 937773000727 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 937773000728 RPB10 interaction site [polypeptide binding]; other site 937773000729 RPB1 interaction site [polypeptide binding]; other site 937773000730 RPB11 interaction site [polypeptide binding]; other site 937773000731 RPB3 interaction site [polypeptide binding]; other site 937773000732 RPB12 interaction site [polypeptide binding]; other site 937773000733 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 937773000734 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 937773000735 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 937773000736 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 937773000737 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 937773000738 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 937773000739 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 937773000740 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 937773000741 G-loop; other site 937773000742 DNA binding site [nucleotide binding] 937773000743 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 937773000744 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 937773000745 S17 interaction site [polypeptide binding]; other site 937773000746 S8 interaction site; other site 937773000747 16S rRNA interaction site [nucleotide binding]; other site 937773000748 streptomycin interaction site [chemical binding]; other site 937773000749 23S rRNA interaction site [nucleotide binding]; other site 937773000750 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 937773000751 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 937773000752 elongation factor G; Reviewed; Region: PRK00007 937773000753 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 937773000754 G1 box; other site 937773000755 putative GEF interaction site [polypeptide binding]; other site 937773000756 GTP/Mg2+ binding site [chemical binding]; other site 937773000757 Switch I region; other site 937773000758 G2 box; other site 937773000759 G3 box; other site 937773000760 Switch II region; other site 937773000761 G4 box; other site 937773000762 G5 box; other site 937773000763 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 937773000764 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 937773000765 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 937773000766 elongation factor Tu; Reviewed; Region: PRK00049 937773000767 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 937773000768 G1 box; other site 937773000769 GEF interaction site [polypeptide binding]; other site 937773000770 GTP/Mg2+ binding site [chemical binding]; other site 937773000771 Switch I region; other site 937773000772 G2 box; other site 937773000773 G3 box; other site 937773000774 Switch II region; other site 937773000775 G4 box; other site 937773000776 G5 box; other site 937773000777 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 937773000778 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 937773000779 Antibiotic Binding Site [chemical binding]; other site 937773000780 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 937773000781 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 937773000782 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 937773000783 metal binding site [ion binding]; metal-binding site 937773000784 dimer interface [polypeptide binding]; other site 937773000785 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 937773000786 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 937773000787 substrate-cofactor binding pocket; other site 937773000788 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773000789 catalytic residue [active] 937773000790 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 937773000791 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773000792 NAD(P) binding site [chemical binding]; other site 937773000793 active site 937773000794 Transposase IS200 like; Region: Y1_Tnp; cl00848 937773000795 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 937773000796 potential frameshift: common BLAST hit: gi|289550013|ref|YP_003470917.1| ABC transporter (ATP-binding protein) 937773000797 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773000798 Walker A/P-loop; other site 937773000799 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 937773000800 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 937773000801 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 937773000802 homodimer interface [polypeptide binding]; other site 937773000803 substrate-cofactor binding pocket; other site 937773000804 catalytic residue [active] 937773000805 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 937773000806 putative catalytic site [active] 937773000807 metal binding site A [ion binding]; metal-binding site 937773000808 phosphate binding site [ion binding]; other site 937773000809 metal binding site C [ion binding]; metal-binding site 937773000810 metal binding site B [ion binding]; metal-binding site 937773000811 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 937773000812 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 937773000813 motif II; other site 937773000814 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 937773000815 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 937773000816 Substrate-binding site [chemical binding]; other site 937773000817 Substrate specificity [chemical binding]; other site 937773000818 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 937773000819 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 937773000820 Substrate-binding site [chemical binding]; other site 937773000821 Substrate specificity [chemical binding]; other site 937773000822 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 937773000823 nucleoside/Zn binding site; other site 937773000824 dimer interface [polypeptide binding]; other site 937773000825 catalytic motif [active] 937773000826 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 937773000827 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 937773000828 active site 937773000829 motif I; other site 937773000830 motif II; other site 937773000831 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 937773000832 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 937773000833 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 937773000834 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 937773000835 Walker A/P-loop; other site 937773000836 ATP binding site [chemical binding]; other site 937773000837 Q-loop/lid; other site 937773000838 ABC transporter signature motif; other site 937773000839 Walker B; other site 937773000840 D-loop; other site 937773000841 H-loop/switch region; other site 937773000842 Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642 937773000843 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 937773000844 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 937773000845 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 937773000846 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 937773000847 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 937773000848 putative active site [active] 937773000849 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 937773000850 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 937773000851 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 937773000852 active site turn [active] 937773000853 phosphorylation site [posttranslational modification] 937773000854 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 937773000855 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 937773000856 putative active site cavity [active] 937773000857 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 937773000858 active site 937773000859 trimer interface [polypeptide binding]; other site 937773000860 allosteric site; other site 937773000861 active site lid [active] 937773000862 hexamer (dimer of trimers) interface [polypeptide binding]; other site 937773000863 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 937773000864 active site 937773000865 dimer interface [polypeptide binding]; other site 937773000866 magnesium binding site [ion binding]; other site 937773000867 Predicted sugar phosphate isomerase involved in capsule formation [Cell envelope biogenesis, outer membrane]; Region: GutQ; COG0794 937773000868 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 937773000869 tetramer interface [polypeptide binding]; other site 937773000870 active site 937773000871 Flavin Reductases; Region: FlaRed; cl00801 937773000872 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773000873 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773000874 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 937773000875 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773000876 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 937773000877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773000878 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 937773000879 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 937773000880 Adhesion protein FadA; Region: FadA; pfam09403 937773000881 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 937773000882 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 937773000883 catalytic core [active] 937773000884 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 937773000885 acyl-CoA synthetase; Validated; Region: PRK07638 937773000886 AMP-binding enzyme; Region: AMP-binding; cl15778 937773000887 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 937773000888 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 937773000889 dimer interface [polypeptide binding]; other site 937773000890 active site 937773000891 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 937773000892 dimer interface [polypeptide binding]; other site 937773000893 substrate binding site [chemical binding]; other site 937773000894 ATP binding site [chemical binding]; other site 937773000895 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 937773000896 ligand binding site [chemical binding]; other site 937773000897 active site 937773000898 UGI interface [polypeptide binding]; other site 937773000899 catalytic site [active] 937773000900 Protein of unknown function (DUF423); Region: DUF423; cl01008 937773000901 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 937773000902 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 937773000903 FeS/SAM binding site; other site 937773000904 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 937773000905 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 937773000906 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 937773000907 dimer interface [polypeptide binding]; other site 937773000908 substrate binding pocket (H-site) [chemical binding]; other site 937773000909 N-terminal domain interface [polypeptide binding]; other site 937773000910 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 937773000911 amino acid transporter; Region: 2A0306; TIGR00909 937773000912 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 937773000913 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 937773000914 Predicted membrane protein [Function unknown]; Region: COG2311 937773000915 Protein of unknown function (DUF418); Region: DUF418; cl12135 937773000916 Protein of unknown function (DUF418); Region: DUF418; cl12135 937773000917 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 937773000918 Helix-turn-helix domains; Region: HTH; cl00088 937773000919 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 937773000920 multidrug resistance protein MdtN; Provisional; Region: PRK10476 937773000921 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 937773000922 E3 interaction surface; other site 937773000923 lipoyl attachment site [posttranslational modification]; other site 937773000924 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 937773000925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773000926 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 937773000927 putative substrate translocation pore; other site 937773000928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773000929 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 937773000930 dimerization interface [polypeptide binding]; other site 937773000931 putative DNA binding site [nucleotide binding]; other site 937773000932 putative Zn2+ binding site [ion binding]; other site 937773000933 arsenical pump membrane protein; Provisional; Region: PRK15445 937773000934 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 937773000935 transmembrane helices; other site 937773000936 Low molecular weight phosphatase family; Region: LMWPc; cd00115 937773000937 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 937773000938 active site 937773000939 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 937773000940 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 937773000941 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 937773000942 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 937773000943 Chlorite dismutase; Region: Chlor_dismutase; cl01280 937773000944 PemK-like protein; Region: PemK; cl00995 937773000945 Uncharacterized conserved protein [Function unknown]; Region: COG2966 937773000946 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 937773000947 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 937773000948 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 937773000949 transmembrane helices; other site 937773000950 Helix-turn-helix domains; Region: HTH; cl00088 937773000951 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 937773000952 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 937773000953 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 937773000954 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 937773000955 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 937773000956 active site 937773000957 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 937773000958 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 937773000959 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 937773000960 active site 937773000961 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 937773000962 active site 937773000963 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 937773000964 active site 937773000965 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 937773000966 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 937773000967 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 937773000968 Coenzyme A binding pocket [chemical binding]; other site 937773000969 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 937773000970 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 937773000971 Zn2+ binding site [ion binding]; other site 937773000972 Mg2+ binding site [ion binding]; other site 937773000973 YwhD family; Region: YwhD; pfam08741 937773000974 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 937773000975 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 937773000976 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 937773000977 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 937773000978 active site 937773000979 HIGH motif; other site 937773000980 KMSK motif region; other site 937773000981 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 937773000982 tRNA binding surface [nucleotide binding]; other site 937773000983 anticodon binding site; other site 937773000984 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 937773000985 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 937773000986 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 937773000987 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 937773000988 putative binding site residues; other site 937773000989 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 937773000990 ABC-ATPase subunit interface; other site 937773000991 dimer interface [polypeptide binding]; other site 937773000992 putative PBP binding regions; other site 937773000993 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 937773000994 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 937773000995 motif II; other site 937773000996 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 937773000997 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 937773000998 Helix-turn-helix domains; Region: HTH; cl00088 937773000999 Protein of unknown function, DUF606; Region: DUF606; cl01273 937773001000 Protein of unknown function, DUF606; Region: DUF606; cl01273 937773001001 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 937773001002 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 937773001003 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 937773001004 DNA binding site [nucleotide binding] 937773001005 Int/Topo IB signature motif; other site 937773001006 active site 937773001007 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646 937773001008 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 937773001009 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 937773001010 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 937773001011 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 937773001012 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 937773001013 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 937773001014 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 937773001015 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 937773001016 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 937773001017 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 937773001018 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 937773001019 metal binding site [ion binding]; metal-binding site 937773001020 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 937773001021 ABC-ATPase subunit interface; other site 937773001022 dimer interface [polypeptide binding]; other site 937773001023 putative PBP binding regions; other site 937773001024 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 937773001025 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 937773001026 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 937773001027 Helix-turn-helix domains; Region: HTH; cl00088 937773001028 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 937773001029 FeoA domain; Region: FeoA; cl00838 937773001030 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 937773001031 ABC-ATPase subunit interface; other site 937773001032 dimer interface [polypeptide binding]; other site 937773001033 putative PBP binding regions; other site 937773001034 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 937773001035 ABC-ATPase subunit interface; other site 937773001036 dimer interface [polypeptide binding]; other site 937773001037 putative PBP binding regions; other site 937773001038 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 937773001039 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 937773001040 siderophore binding site; other site 937773001041 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 937773001042 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 937773001043 dimer interface [polypeptide binding]; other site 937773001044 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773001045 catalytic residue [active] 937773001046 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 937773001047 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773001048 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 937773001049 IucA / IucC family; Region: IucA_IucC; pfam04183 937773001050 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 937773001051 drug efflux system protein MdtG; Provisional; Region: PRK09874 937773001052 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773001053 putative substrate translocation pore; other site 937773001054 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 937773001055 IucA / IucC family; Region: IucA_IucC; pfam04183 937773001056 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 937773001057 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 937773001058 IucA / IucC family; Region: IucA_IucC; pfam04183 937773001059 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 937773001060 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 937773001061 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 937773001062 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 937773001063 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 937773001064 dimer interface [polypeptide binding]; other site 937773001065 active site 937773001066 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 937773001067 catalytic residues [active] 937773001068 substrate binding site [chemical binding]; other site 937773001069 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 937773001070 ParB-like nuclease domain; Region: ParBc; cl02129 937773001071 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 937773001072 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 937773001073 putative trimer interface [polypeptide binding]; other site 937773001074 putative CoA binding site [chemical binding]; other site 937773001075 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 937773001076 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 937773001077 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 937773001078 Walker A/P-loop; other site 937773001079 ATP binding site [chemical binding]; other site 937773001080 Q-loop/lid; other site 937773001081 ABC transporter signature motif; other site 937773001082 Walker B; other site 937773001083 D-loop; other site 937773001084 H-loop/switch region; other site 937773001085 ABC-2 type transporter; Region: ABC2_membrane; cl11417 937773001086 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 937773001087 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 937773001088 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 937773001089 active site 937773001090 nucleotide binding site [chemical binding]; other site 937773001091 HIGH motif; other site 937773001092 KMSKS motif; other site 937773001093 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773001094 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 937773001095 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 937773001096 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 937773001097 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 937773001098 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 937773001099 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773001100 Walker A/P-loop; other site 937773001101 ATP binding site [chemical binding]; other site 937773001102 Q-loop/lid; other site 937773001103 ABC transporter signature motif; other site 937773001104 Walker B; other site 937773001105 D-loop; other site 937773001106 H-loop/switch region; other site 937773001107 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 937773001108 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 937773001109 G1 box; other site 937773001110 GTP/Mg2+ binding site [chemical binding]; other site 937773001111 Switch I region; other site 937773001112 G2 box; other site 937773001113 G3 box; other site 937773001114 Switch II region; other site 937773001115 G4 box; other site 937773001116 G5 box; other site 937773001117 Nucleoside recognition; Region: Gate; cl00486 937773001118 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 937773001119 Nucleoside recognition; Region: Gate; cl00486 937773001120 FeoA domain; Region: FeoA; cl00838 937773001121 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 937773001122 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 937773001123 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 937773001124 Uncharacterized conserved protein [Function unknown]; Region: COG1284 937773001125 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 937773001126 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 937773001127 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 937773001128 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 937773001129 Walker A/P-loop; other site 937773001130 ATP binding site [chemical binding]; other site 937773001131 Q-loop/lid; other site 937773001132 ABC transporter signature motif; other site 937773001133 Walker B; other site 937773001134 D-loop; other site 937773001135 H-loop/switch region; other site 937773001136 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 937773001137 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 937773001138 ABC-ATPase subunit interface; other site 937773001139 dimer interface [polypeptide binding]; other site 937773001140 putative PBP binding regions; other site 937773001141 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 937773001142 ABC-ATPase subunit interface; other site 937773001143 dimer interface [polypeptide binding]; other site 937773001144 putative PBP binding regions; other site 937773001145 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 937773001146 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773001147 putative substrate translocation pore; other site 937773001148 Uncharacterized membrane protein [Function unknown]; Region: COG3949 937773001149 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 937773001150 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 937773001151 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 937773001152 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 937773001153 Coenzyme A binding pocket [chemical binding]; other site 937773001154 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773001155 NAD(P) binding site [chemical binding]; other site 937773001156 active site 937773001157 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 937773001158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 937773001159 active site 937773001160 phosphorylation site [posttranslational modification] 937773001161 intermolecular recognition site; other site 937773001162 dimerization interface [polypeptide binding]; other site 937773001163 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 937773001164 DNA binding site [nucleotide binding] 937773001165 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 937773001166 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 937773001167 ATP binding site [chemical binding]; other site 937773001168 Mg2+ binding site [ion binding]; other site 937773001169 G-X-G motif; other site 937773001170 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 937773001171 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 937773001172 Walker A/P-loop; other site 937773001173 ATP binding site [chemical binding]; other site 937773001174 Q-loop/lid; other site 937773001175 ABC transporter signature motif; other site 937773001176 Walker B; other site 937773001177 D-loop; other site 937773001178 H-loop/switch region; other site 937773001179 FtsX-like permease family; Region: FtsX; cl15850 937773001180 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 937773001181 Phosphate transporter family; Region: PHO4; cl00396 937773001182 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 937773001183 putative peptidoglycan binding site; other site 937773001184 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 937773001185 putative peptidoglycan binding site; other site 937773001186 NlpC/P60 family; Region: NLPC_P60; cl11438 937773001187 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 937773001188 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 937773001189 thiamine phosphate binding site [chemical binding]; other site 937773001190 active site 937773001191 pyrophosphate binding site [ion binding]; other site 937773001192 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 937773001193 thiS-thiF/thiG interaction site; other site 937773001194 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 937773001195 ThiS interaction site; other site 937773001196 putative active site [active] 937773001197 tetramer interface [polypeptide binding]; other site 937773001198 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 937773001199 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 937773001200 ATP binding site [chemical binding]; other site 937773001201 substrate interface [chemical binding]; other site 937773001202 Transcriptional regulator; Region: Transcrip_reg; cl00361 937773001203 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 937773001204 Protein of unknown function (DUF402); Region: DUF402; cl00979 937773001205 Transcriptional regulator [Transcription]; Region: LysR; COG0583 937773001206 Helix-turn-helix domains; Region: HTH; cl00088 937773001207 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 937773001208 dimerization interface [polypeptide binding]; other site 937773001209 sugar efflux transporter; Region: 2A0120; TIGR00899 937773001210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773001211 putative substrate translocation pore; other site 937773001212 Protein of unknown function (DUF456); Region: DUF456; cl01069 937773001213 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 937773001214 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 937773001215 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 937773001216 Coenzyme A binding pocket [chemical binding]; other site 937773001217 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 937773001218 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 937773001219 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 937773001220 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 937773001221 Bacitracin resistance protein BacA; Region: BacA; cl00858 937773001222 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 937773001223 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 937773001224 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773001225 Walker A/P-loop; other site 937773001226 ATP binding site [chemical binding]; other site 937773001227 Q-loop/lid; other site 937773001228 ABC transporter signature motif; other site 937773001229 Walker B; other site 937773001230 D-loop; other site 937773001231 H-loop/switch region; other site 937773001232 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 937773001233 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 937773001234 Walker A/P-loop; other site 937773001235 ATP binding site [chemical binding]; other site 937773001236 Q-loop/lid; other site 937773001237 ABC transporter signature motif; other site 937773001238 Walker B; other site 937773001239 D-loop; other site 937773001240 H-loop/switch region; other site 937773001241 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 937773001242 Helix-turn-helix domains; Region: HTH; cl00088 937773001243 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 937773001244 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773001245 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 937773001246 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 937773001247 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 937773001248 active site 937773001249 catalytic tetrad [active] 937773001250 potential frameshift: common BLAST hit: gi|29377686|ref|NP_816840.1| abortive phage resistance protein 937773001251 Dynein light intermediate chain (DLIC); Region: DLIC; pfam05783 937773001252 AAA domain; Region: AAA_21; pfam13304 937773001253 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773001254 ABC transporter signature motif; other site 937773001255 Walker B; other site 937773001256 D-loop; other site 937773001257 H-loop/switch region; other site 937773001258 malate dehydrogenase; Reviewed; Region: PRK06223 937773001259 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 937773001260 NAD(P) binding site [chemical binding]; other site 937773001261 dimer interface [polypeptide binding]; other site 937773001262 tetramer (dimer of dimers) interface [polypeptide binding]; other site 937773001263 substrate binding site [chemical binding]; other site 937773001264 CAAX protease self-immunity; Region: Abi; cl00558 937773001265 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 937773001266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773001267 Major Facilitator Superfamily; Region: MFS_1; pfam07690 937773001268 putative substrate translocation pore; other site 937773001269 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 937773001270 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 937773001271 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 937773001272 putative deacylase active site [active] 937773001273 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 937773001274 Helix-turn-helix domains; Region: HTH; cl00088 937773001275 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 937773001276 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 937773001277 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 937773001278 putative substrate binding site [chemical binding]; other site 937773001279 putative ATP binding site [chemical binding]; other site 937773001280 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 937773001281 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 937773001282 active site 937773001283 phosphorylation site [posttranslational modification] 937773001284 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 937773001285 P-loop; other site 937773001286 active site 937773001287 phosphorylation site [posttranslational modification] 937773001288 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 937773001289 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 937773001290 Domain of unknown function DUF21; Region: DUF21; pfam01595 937773001291 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 937773001292 Transporter associated domain; Region: CorC_HlyC; cl08393 937773001293 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 937773001294 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 937773001295 Ligand binding site; other site 937773001296 Putative Catalytic site; other site 937773001297 DXD motif; other site 937773001298 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 937773001299 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 937773001300 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 937773001301 FeS/SAM binding site; other site 937773001302 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 937773001303 active site 937773001304 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 937773001305 Ligand Binding Site [chemical binding]; other site 937773001306 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 937773001307 Glutamine amidotransferase class-I; Region: GATase; pfam00117 937773001308 glutamine binding [chemical binding]; other site 937773001309 catalytic triad [active] 937773001310 aminodeoxychorismate synthase; Provisional; Region: PRK07508 937773001311 chorismate binding enzyme; Region: Chorismate_bind; cl10555 937773001312 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 937773001313 substrate-cofactor binding pocket; other site 937773001314 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773001315 catalytic residue [active] 937773001316 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 937773001317 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 937773001318 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 937773001319 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 937773001320 Sulfatase; Region: Sulfatase; cl10460 937773001321 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 937773001322 active site 937773001323 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39B; cd02418 937773001324 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 937773001325 putative active site [active] 937773001326 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 937773001327 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773001328 Walker A/P-loop; other site 937773001329 ATP binding site [chemical binding]; other site 937773001330 Q-loop/lid; other site 937773001331 ABC transporter signature motif; other site 937773001332 Walker B; other site 937773001333 D-loop; other site 937773001334 H-loop/switch region; other site 937773001335 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 937773001336 ZIP Zinc transporter; Region: Zip; pfam02535 937773001337 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 937773001338 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 937773001339 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 937773001340 ABC transporter; Region: ABC_tran_2; pfam12848 937773001341 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 937773001342 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 937773001343 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 937773001344 ATP binding site [chemical binding]; other site 937773001345 putative Mg++ binding site [ion binding]; other site 937773001346 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 937773001347 nucleotide binding region [chemical binding]; other site 937773001348 ATP-binding site [chemical binding]; other site 937773001349 RQC domain; Region: RQC; cl09632 937773001350 HRDC domain; Region: HRDC; cl02578 937773001351 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 937773001352 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 937773001353 Walker A/P-loop; other site 937773001354 ATP binding site [chemical binding]; other site 937773001355 Q-loop/lid; other site 937773001356 ABC transporter signature motif; other site 937773001357 Walker B; other site 937773001358 D-loop; other site 937773001359 H-loop/switch region; other site 937773001360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 937773001361 dimer interface [polypeptide binding]; other site 937773001362 conserved gate region; other site 937773001363 ABC-ATPase subunit interface; other site 937773001364 NMT1-like family; Region: NMT1_2; cl15260 937773001365 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 937773001366 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 937773001367 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 937773001368 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773001369 homodimer interface [polypeptide binding]; other site 937773001370 catalytic residue [active] 937773001371 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 937773001372 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 937773001373 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 937773001374 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 937773001375 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773001376 putative substrate translocation pore; other site 937773001377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 937773001378 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 937773001379 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 937773001380 H+ Antiporter protein; Region: 2A0121; TIGR00900 937773001381 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 937773001382 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 937773001383 Predicted permeases [General function prediction only]; Region: RarD; COG2962 937773001384 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 937773001385 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 937773001386 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 937773001387 Class I ribonucleotide reductase; Region: RNR_I; cd01679 937773001388 active site 937773001389 dimer interface [polypeptide binding]; other site 937773001390 catalytic residues [active] 937773001391 effector binding site; other site 937773001392 R2 peptide binding site; other site 937773001393 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 937773001394 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 937773001395 dimer interface [polypeptide binding]; other site 937773001396 putative radical transfer pathway; other site 937773001397 diiron center [ion binding]; other site 937773001398 tyrosyl radical; other site 937773001399 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 937773001400 CHY zinc finger; Region: zf-CHY; pfam05495 937773001401 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906 937773001402 FAD binding domain; Region: FAD_binding_4; pfam01565 937773001403 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 937773001404 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 937773001405 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 937773001406 Glycerate kinase family; Region: Gly_kinase; cl00841 937773001407 peptidase T; Region: peptidase-T; TIGR01882 937773001408 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 937773001409 metal binding site [ion binding]; metal-binding site 937773001410 dimer interface [polypeptide binding]; other site 937773001411 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 937773001412 Uncharacterized conserved protein [Function unknown]; Region: COG2966 937773001413 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 937773001414 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 937773001415 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 937773001416 metal binding site [ion binding]; metal-binding site 937773001417 active site 937773001418 I-site; other site 937773001419 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 937773001420 Mg++ binding site [ion binding]; other site 937773001421 putative catalytic motif [active] 937773001422 substrate binding site [chemical binding]; other site 937773001423 Uncharacterized conserved protein [Function unknown]; Region: COG1739 937773001424 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 937773001425 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 937773001426 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 937773001427 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 937773001428 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 937773001429 ATP binding site [chemical binding]; other site 937773001430 putative Mg++ binding site [ion binding]; other site 937773001431 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 937773001432 nucleotide binding region [chemical binding]; other site 937773001433 ATP-binding site [chemical binding]; other site 937773001434 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 937773001435 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 937773001436 active site 937773001437 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 937773001438 30S subunit binding site; other site 937773001439 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 937773001440 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 937773001441 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 937773001442 nucleotide binding region [chemical binding]; other site 937773001443 ATP-binding site [chemical binding]; other site 937773001444 SEC-C motif; Region: SEC-C; pfam02810 937773001445 peptide chain release factor 2; Provisional; Region: PRK06746 937773001446 RF-1 domain; Region: RF-1; cl02875 937773001447 RF-1 domain; Region: RF-1; cl02875 937773001448 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 937773001449 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 937773001450 excinuclease ABC subunit B; Provisional; Region: PRK05298 937773001451 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 937773001452 ATP binding site [chemical binding]; other site 937773001453 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 937773001454 nucleotide binding region [chemical binding]; other site 937773001455 ATP-binding site [chemical binding]; other site 937773001456 Ultra-violet resistance protein B; Region: UvrB; pfam12344 937773001457 UvrB/uvrC motif; Region: UVR; pfam02151 937773001458 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 937773001459 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 937773001460 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 937773001461 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 937773001462 HPr kinase/phosphorylase; Provisional; Region: PRK05428 937773001463 DRTGG domain; Region: DRTGG; cl12147 937773001464 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 937773001465 Hpr binding site; other site 937773001466 active site 937773001467 homohexamer subunit interaction site [polypeptide binding]; other site 937773001468 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 937773001469 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 937773001470 trimer interface [polypeptide binding]; other site 937773001471 active site 937773001472 substrate binding site [chemical binding]; other site 937773001473 CoA binding site [chemical binding]; other site 937773001474 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 937773001475 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 937773001476 TPR motif; other site 937773001477 binding surface 937773001478 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 937773001479 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773001480 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 937773001481 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 937773001482 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 937773001483 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 937773001484 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 937773001485 phosphate binding site [ion binding]; other site 937773001486 putative substrate binding pocket [chemical binding]; other site 937773001487 dimer interface [polypeptide binding]; other site 937773001488 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 937773001489 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 937773001490 Clp protease; Region: CLP_protease; pfam00574 937773001491 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 937773001492 oligomer interface [polypeptide binding]; other site 937773001493 active site residues [active] 937773001494 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 937773001495 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 937773001496 Coenzyme A binding pocket [chemical binding]; other site 937773001497 potential frameshift: common BLAST hit: gi|289551369|ref|YP_003472273.1| cell division inhibitor 937773001498 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773001499 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773001500 NAD(P) binding site [chemical binding]; other site 937773001501 active site 937773001502 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 937773001503 Predicted transcriptional regulator [Transcription]; Region: COG3388 937773001504 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 937773001505 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773001506 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 937773001507 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 937773001508 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 937773001509 Phosphoglycerate kinase; Region: PGK; pfam00162 937773001510 substrate binding site [chemical binding]; other site 937773001511 hinge regions; other site 937773001512 ADP binding site [chemical binding]; other site 937773001513 catalytic site [active] 937773001514 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 937773001515 substrate binding site [chemical binding]; other site 937773001516 dimer interface [polypeptide binding]; other site 937773001517 catalytic triad [active] 937773001518 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 937773001519 Sulfatase; Region: Sulfatase; cl10460 937773001520 enolase; Provisional; Region: eno; PRK00077 937773001521 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 937773001522 dimer interface [polypeptide binding]; other site 937773001523 metal binding site [ion binding]; metal-binding site 937773001524 substrate binding pocket [chemical binding]; other site 937773001525 Preprotein translocase SecG subunit; Region: SecG; cl09123 937773001526 Esterase/lipase [General function prediction only]; Region: COG1647 937773001527 ribonuclease R; Region: RNase_R; TIGR02063 937773001528 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 937773001529 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 937773001530 RNB domain; Region: RNB; pfam00773 937773001531 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 937773001532 RNA binding site [nucleotide binding]; other site 937773001533 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 937773001534 SmpB-tmRNA interface; other site 937773001535 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 937773001536 Int/Topo IB signature motif; other site 937773001537 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 937773001538 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 937773001539 non-specific DNA binding site [nucleotide binding]; other site 937773001540 salt bridge; other site 937773001541 sequence-specific DNA binding site [nucleotide binding]; other site 937773001542 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 937773001543 salt bridge; other site 937773001544 non-specific DNA binding site [nucleotide binding]; other site 937773001545 sequence-specific DNA binding site [nucleotide binding]; other site 937773001546 Protein of unknown function (DUF1474); Region: DUF1474; pfam07342 937773001547 Uncharacterized conserved protein [Function unknown]; Region: COG4983 937773001548 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 937773001549 nucleotide binding site [chemical binding]; other site 937773001550 D5 N terminal like; Region: D5_N; cl07360 937773001551 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 937773001552 Phage-related protein [Function unknown]; Region: COG4695; cl01923 937773001553 Phage portal protein; Region: Phage_portal; pfam04860 937773001554 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 937773001555 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 937773001556 Phage capsid family; Region: Phage_capsid; pfam05065 937773001557 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 937773001558 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 937773001559 Phage Terminase; Region: Terminase_1; pfam03354 937773001560 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 937773001561 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 937773001562 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 937773001563 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 937773001564 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 937773001565 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 937773001566 active site 937773001567 metal binding site [ion binding]; metal-binding site 937773001568 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 937773001569 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 937773001570 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 937773001571 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 937773001572 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 937773001573 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 937773001574 Coenzyme A binding pocket [chemical binding]; other site 937773001575 OsmC-like protein; Region: OsmC; cl00767 937773001576 D-lactate dehydrogenase; Validated; Region: PRK08605 937773001577 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773001578 3-dehydroquinate dehydratase, type I; Region: aroD; TIGR01093 937773001579 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 937773001580 active site 937773001581 catalytic residue [active] 937773001582 dimer interface [polypeptide binding]; other site 937773001583 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 937773001584 putative FMN binding site [chemical binding]; other site 937773001585 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 937773001586 catalytic residues [active] 937773001587 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 937773001588 ArsC family; Region: ArsC; pfam03960 937773001589 putative ArsC-like catalytic residues; other site 937773001590 putative TRX-like catalytic residues [active] 937773001591 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 937773001592 lipoyl attachment site [posttranslational modification]; other site 937773001593 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 937773001594 putative active site [active] 937773001595 putative metal binding site [ion binding]; other site 937773001596 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 937773001597 catalytic residues [active] 937773001598 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 937773001599 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 937773001600 Walker A/P-loop; other site 937773001601 ATP binding site [chemical binding]; other site 937773001602 Q-loop/lid; other site 937773001603 ABC transporter signature motif; other site 937773001604 Walker B; other site 937773001605 D-loop; other site 937773001606 H-loop/switch region; other site 937773001607 NIL domain; Region: NIL; cl09633 937773001608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 937773001609 dimer interface [polypeptide binding]; other site 937773001610 conserved gate region; other site 937773001611 ABC-ATPase subunit interface; other site 937773001612 NMT1-like family; Region: NMT1_2; cl15260 937773001613 NMT1-like family; Region: NMT1_2; cl15260 937773001614 Domain of unknown function (DUF368); Region: DUF368; cl00893 937773001615 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 937773001616 FeS assembly ATPase SufC; Region: sufC; TIGR01978 937773001617 Walker A/P-loop; other site 937773001618 ATP binding site [chemical binding]; other site 937773001619 Q-loop/lid; other site 937773001620 ABC transporter signature motif; other site 937773001621 Walker B; other site 937773001622 D-loop; other site 937773001623 H-loop/switch region; other site 937773001624 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 937773001625 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 937773001626 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 937773001627 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 937773001628 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 937773001629 catalytic residue [active] 937773001630 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 937773001631 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 937773001632 trimerization site [polypeptide binding]; other site 937773001633 active site 937773001634 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 937773001635 FeS assembly protein SufB; Region: sufB; TIGR01980 937773001636 integrase; Provisional; Region: int; PHA02601 937773001637 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 937773001638 Int/Topo IB signature motif; other site 937773001639 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 937773001640 non-specific DNA binding site [nucleotide binding]; other site 937773001641 salt bridge; other site 937773001642 sequence-specific DNA binding site [nucleotide binding]; other site 937773001643 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 937773001644 Catalytic site [active] 937773001645 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 937773001646 non-specific DNA binding site [nucleotide binding]; other site 937773001647 salt bridge; other site 937773001648 sequence-specific DNA binding site [nucleotide binding]; other site 937773001649 AntA/AntB antirepressor; Region: AntA; cl01430 937773001650 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 937773001651 ORF6C domain; Region: ORF6C; pfam10552 937773001652 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 937773001653 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 937773001654 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 937773001655 ERF superfamily; Region: ERF; pfam04404 937773001656 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 937773001657 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 937773001658 dimer interface [polypeptide binding]; other site 937773001659 ssDNA binding site [nucleotide binding]; other site 937773001660 tetramer (dimer of dimers) interface [polypeptide binding]; other site 937773001661 Protein of unknown function (DUF968); Region: DUF968; pfam06147 937773001662 Helix-turn-helix domains; Region: HTH; cl00088 937773001663 hypothetical protein; Validated; Region: PRK08116 937773001664 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773001665 Protein of unknown function (DUF3269); Region: DUF3269; pfam11673 937773001666 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 937773001667 YopX protein; Region: YopX; cl09859 937773001668 Dimeric dUTPase [Carbohydrate transport and metabolism]; Region: COG4508 937773001669 dUTPase; Region: dUTPase_2; pfam08761 937773001670 Terminase small subunit; Region: Terminase_2; cl01513 937773001671 Phage terminase large subunit; Region: Terminase_3; cl12054 937773001672 Terminase-like family; Region: Terminase_6; pfam03237 937773001673 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 937773001674 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 937773001675 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 937773001676 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 937773001677 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 937773001678 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 937773001679 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 937773001680 Phage major tail protein 2; Region: Phage_tail_2; cl11463 937773001681 Phage protein; Region: DUF3647; cl10335 937773001682 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 937773001683 Phage-related protein [Function unknown]; Region: COG5412 937773001684 hypothetical protein; Region: PHA01795 937773001685 Phage tail protein; Region: Sipho_tail; pfam05709 937773001686 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 937773001687 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 937773001688 active site 937773001689 catalytic triad [active] 937773001690 oxyanion hole [active] 937773001691 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 937773001692 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 937773001693 NlpC/P60 family; Region: NLPC_P60; cl11438 937773001694 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 937773001695 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 937773001696 Bacteriophage holin; Region: Phage_holin_1; cl02344 937773001697 NlpC/P60 family; Region: NLPC_P60; cl11438 937773001698 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 937773001699 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 937773001700 Domain of unknown function DUF21; Region: DUF21; pfam01595 937773001701 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 937773001702 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 937773001703 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 937773001704 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 937773001705 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 937773001706 Protein of unknown function DUF72; Region: DUF72; cl00777 937773001707 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 937773001708 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 937773001709 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 937773001710 active site 937773001711 metal binding site [ion binding]; metal-binding site 937773001712 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 937773001713 lipoyl synthase; Provisional; Region: PRK05481 937773001714 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 937773001715 FeS/SAM binding site; other site 937773001716 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 937773001717 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 937773001718 Protein of unknown function DUF86; Region: DUF86; cl01031 937773001719 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 937773001720 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 937773001721 active site 937773001722 motif I; other site 937773001723 motif II; other site 937773001724 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 937773001725 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 937773001726 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773001727 NifU-like domain; Region: NifU; cl00484 937773001728 Protein of unknown function (DUF1462); Region: DUF1462; cl11552 937773001729 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 937773001730 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 937773001731 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 937773001732 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 937773001733 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 937773001734 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 937773001735 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 937773001736 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 937773001737 interface (dimer of trimers) [polypeptide binding]; other site 937773001738 Substrate-binding/catalytic site; other site 937773001739 Zn-binding sites [ion binding]; other site 937773001740 Predicted permease [General function prediction only]; Region: COG2056 937773001741 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 937773001742 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 937773001743 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 937773001744 CoenzymeA binding site [chemical binding]; other site 937773001745 subunit interaction site [polypeptide binding]; other site 937773001746 PHB binding site; other site 937773001747 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 937773001748 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 937773001749 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 937773001750 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 937773001751 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 937773001752 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 937773001753 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 937773001754 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 937773001755 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 937773001756 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 937773001757 Kinase associated protein B; Region: KapB; pfam08810 937773001758 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 937773001759 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 937773001760 active site 937773001761 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 937773001762 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 937773001763 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 937773001764 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 937773001765 DNA-binding site [nucleotide binding]; DNA binding site 937773001766 RNA-binding motif; other site 937773001767 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 937773001768 RNA binding site [nucleotide binding]; other site 937773001769 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 937773001770 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 937773001771 Glutamate binding site [chemical binding]; other site 937773001772 homodimer interface [polypeptide binding]; other site 937773001773 NAD binding site [chemical binding]; other site 937773001774 catalytic residues [active] 937773001775 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 937773001776 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 937773001777 inhibitor-cofactor binding pocket; inhibition site 937773001778 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773001779 catalytic residue [active] 937773001780 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 937773001781 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 937773001782 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 937773001783 NAD(P) binding site [chemical binding]; other site 937773001784 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 937773001785 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 937773001786 active site 937773001787 catalytic site [active] 937773001788 metal binding site [ion binding]; metal-binding site 937773001789 argininosuccinate lyase; Provisional; Region: PRK00855 937773001790 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 937773001791 active sites [active] 937773001792 tetramer interface [polypeptide binding]; other site 937773001793 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 937773001794 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 937773001795 ANP binding site [chemical binding]; other site 937773001796 Substrate Binding Site II [chemical binding]; other site 937773001797 Substrate Binding Site I [chemical binding]; other site 937773001798 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 937773001799 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 937773001800 active site 937773001801 dimer interface [polypeptide binding]; other site 937773001802 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 937773001803 dimer interface [polypeptide binding]; other site 937773001804 active site 937773001805 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 937773001806 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 937773001807 Catalytic site [active] 937773001808 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 937773001809 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 937773001810 Catalytic site [active] 937773001811 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 937773001812 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 937773001813 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 937773001814 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773001815 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 937773001816 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 937773001817 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 937773001818 Protein of unknown function (DUF1516); Region: DUF1516; cl11654 937773001819 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 937773001820 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 937773001821 putative active site [active] 937773001822 putative NTP binding site [chemical binding]; other site 937773001823 putative nucleic acid binding site [nucleotide binding]; other site 937773001824 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 937773001825 coenzyme A disulfide reductase; Provisional; Region: PRK13512 937773001826 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 937773001827 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 937773001828 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 937773001829 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 937773001830 active site 937773001831 motif I; other site 937773001832 motif II; other site 937773001833 Domain of unknown function DUF59; Region: DUF59; cl00941 937773001834 OpgC protein; Region: OpgC_C; cl00792 937773001835 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 937773001836 catalytic triad [active] 937773001837 catalytic triad [active] 937773001838 oxyanion hole [active] 937773001839 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 937773001840 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 937773001841 Walker A motif; other site 937773001842 ATP binding site [chemical binding]; other site 937773001843 Walker B motif; other site 937773001844 arginine finger; other site 937773001845 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 937773001846 Walker A motif; other site 937773001847 ATP binding site [chemical binding]; other site 937773001848 Walker B motif; other site 937773001849 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 937773001850 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 937773001851 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 937773001852 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 937773001853 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 937773001854 dimer interface [polypeptide binding]; other site 937773001855 active site 937773001856 CoA binding pocket [chemical binding]; other site 937773001857 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 937773001858 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 937773001859 dimer interface [polypeptide binding]; other site 937773001860 active site 937773001861 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 937773001862 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 937773001863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 937773001864 dimer interface [polypeptide binding]; other site 937773001865 conserved gate region; other site 937773001866 putative PBP binding loops; other site 937773001867 ABC-ATPase subunit interface; other site 937773001868 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 937773001869 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 937773001870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 937773001871 dimer interface [polypeptide binding]; other site 937773001872 conserved gate region; other site 937773001873 putative PBP binding loops; other site 937773001874 ABC-ATPase subunit interface; other site 937773001875 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 937773001876 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 937773001877 Walker A/P-loop; other site 937773001878 ATP binding site [chemical binding]; other site 937773001879 Q-loop/lid; other site 937773001880 ABC transporter signature motif; other site 937773001881 Walker B; other site 937773001882 D-loop; other site 937773001883 H-loop/switch region; other site 937773001884 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 937773001885 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 937773001886 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 937773001887 Walker A/P-loop; other site 937773001888 ATP binding site [chemical binding]; other site 937773001889 Q-loop/lid; other site 937773001890 ABC transporter signature motif; other site 937773001891 Walker B; other site 937773001892 D-loop; other site 937773001893 H-loop/switch region; other site 937773001894 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 937773001895 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 937773001896 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 937773001897 peptide binding site [polypeptide binding]; other site 937773001898 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 937773001899 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 937773001900 active site 937773001901 HIGH motif; other site 937773001902 dimer interface [polypeptide binding]; other site 937773001903 KMSKS motif; other site 937773001904 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 937773001905 ArsC family; Region: ArsC; pfam03960 937773001906 putative catalytic residues [active] 937773001907 thiol/disulfide switch; other site 937773001908 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 937773001909 potential frameshift: common BLAST hit: gi|150395106|ref|YP_001317781.1| peptidase S1 and S6 chymotrypsin/Hap 937773001910 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 937773001911 Competence protein CoiA-like family; Region: CoiA; cl11541 937773001912 oligoendopeptidase F; Region: pepF; TIGR00181 937773001913 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 937773001914 active site 937773001915 Zn binding site [ion binding]; other site 937773001916 Peptidase family M48; Region: Peptidase_M48; cl12018 937773001917 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 937773001918 Thioredoxin; Region: Thioredoxin_5; pfam13743 937773001919 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 937773001920 apolar tunnel; other site 937773001921 heme binding site [chemical binding]; other site 937773001922 dimerization interface [polypeptide binding]; other site 937773001923 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 937773001924 putative active site [active] 937773001925 putative metal binding residues [ion binding]; other site 937773001926 signature motif; other site 937773001927 putative triphosphate binding site [ion binding]; other site 937773001928 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 937773001929 synthetase active site [active] 937773001930 NTP binding site [chemical binding]; other site 937773001931 metal binding site [ion binding]; metal-binding site 937773001932 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 937773001933 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 937773001934 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 937773001935 active site 937773001936 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 937773001937 MgtE intracellular N domain; Region: MgtE_N; cl15244 937773001938 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 937773001939 Divalent cation transporter; Region: MgtE; cl00786 937773001940 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 937773001941 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 937773001942 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 937773001943 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773001944 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 937773001945 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 937773001946 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 937773001947 NAD binding site [chemical binding]; other site 937773001948 homotetramer interface [polypeptide binding]; other site 937773001949 homodimer interface [polypeptide binding]; other site 937773001950 substrate binding site [chemical binding]; other site 937773001951 active site 937773001952 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773001953 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 937773001954 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 937773001955 MFS/sugar transport protein; Region: MFS_2; pfam13347 937773001956 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 937773001957 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 937773001958 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 937773001959 Asp-box motif; other site 937773001960 catalytic site [active] 937773001961 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 937773001962 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 937773001963 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 937773001964 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 937773001965 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 937773001966 Putative esterase; Region: Esterase; pfam00756 937773001967 hypothetical protein; Provisional; Region: PRK13679 937773001968 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 937773001969 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 937773001970 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773001971 Walker A/P-loop; other site 937773001972 ATP binding site [chemical binding]; other site 937773001973 Q-loop/lid; other site 937773001974 ABC transporter signature motif; other site 937773001975 Walker B; other site 937773001976 D-loop; other site 937773001977 H-loop/switch region; other site 937773001978 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 937773001979 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 937773001980 putative active site [active] 937773001981 putative NTP binding site [chemical binding]; other site 937773001982 putative nucleic acid binding site [nucleotide binding]; other site 937773001983 CAAX protease self-immunity; Region: Abi; cl00558 937773001984 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 937773001985 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 937773001986 Sulfatase; Region: Sulfatase; cl10460 937773001987 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 937773001988 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773001989 putative substrate translocation pore; other site 937773001990 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 937773001991 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 937773001992 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 937773001993 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 937773001994 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 937773001995 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 937773001996 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 937773001997 YueH-like protein; Region: YueH; pfam14166 937773001998 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 937773001999 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 937773002000 G1 box; other site 937773002001 putative GEF interaction site [polypeptide binding]; other site 937773002002 GTP/Mg2+ binding site [chemical binding]; other site 937773002003 Switch I region; other site 937773002004 G2 box; other site 937773002005 G3 box; other site 937773002006 Switch II region; other site 937773002007 G4 box; other site 937773002008 G5 box; other site 937773002009 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 937773002010 Integral membrane protein TerC family; Region: TerC; cl10468 937773002011 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 937773002012 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 937773002013 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 937773002014 Cation transport protein; Region: TrkH; cl10514 937773002015 potential frameshift: common BLAST hit: gi|73663149|ref|YP_301930.1| poly D-alanine transfer protein 937773002016 DltD central region; Region: DltD_M; pfam04918 937773002017 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 937773002018 DltD N-terminal region; Region: DltD_N; pfam04915 937773002019 DltD central region; Region: DltD_M; pfam04918 937773002020 Phosphopantetheine attachment site; Region: PP-binding; cl09936 937773002021 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 937773002022 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 937773002023 AMP-binding enzyme; Region: AMP-binding; cl15778 937773002024 AMP-binding enzyme; Region: AMP-binding; cl15778 937773002025 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 937773002026 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 937773002027 active site 937773002028 metal binding site [ion binding]; metal-binding site 937773002029 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 937773002030 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 937773002031 DNA polymerase III subunits gamma and tau; Validated; Region: PRK08691 937773002032 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 937773002033 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 937773002034 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 937773002035 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 937773002036 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 937773002037 ComK protein; Region: ComK; cl11560 937773002038 IDEAL domain; Region: IDEAL; cl07452 937773002039 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 937773002040 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 937773002041 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 937773002042 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 937773002043 YolD-like protein; Region: YolD; pfam08863 937773002044 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 937773002045 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 937773002046 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 937773002047 Walker A/P-loop; other site 937773002048 ATP binding site [chemical binding]; other site 937773002049 Q-loop/lid; other site 937773002050 ABC transporter signature motif; other site 937773002051 Walker B; other site 937773002052 D-loop; other site 937773002053 H-loop/switch region; other site 937773002054 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 937773002055 UbiA prenyltransferase family; Region: UbiA; cl00337 937773002056 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 937773002057 chorismate binding enzyme; Region: Chorismate_bind; cl10555 937773002058 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 937773002059 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 937773002060 dimer interface [polypeptide binding]; other site 937773002061 tetramer interface [polypeptide binding]; other site 937773002062 PYR/PP interface [polypeptide binding]; other site 937773002063 TPP binding site [chemical binding]; other site 937773002064 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 937773002065 TPP-binding site; other site 937773002066 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 937773002067 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 937773002068 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 937773002069 substrate binding site [chemical binding]; other site 937773002070 oxyanion hole (OAH) forming residues; other site 937773002071 trimer interface [polypeptide binding]; other site 937773002072 aminotransferase A; Validated; Region: PRK07683 937773002073 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 937773002074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773002075 homodimer interface [polypeptide binding]; other site 937773002076 catalytic residue [active] 937773002077 OpgC protein; Region: OpgC_C; cl00792 937773002078 Acyltransferase family; Region: Acyl_transf_3; pfam01757 937773002079 OpgC protein; Region: OpgC_C; cl00792 937773002080 Acyltransferase family; Region: Acyl_transf_3; pfam01757 937773002081 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 937773002082 active site 937773002083 catalytic triad [active] 937773002084 oxyanion hole [active] 937773002085 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 937773002086 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 937773002087 amidase catalytic site [active] 937773002088 Zn binding residues [ion binding]; other site 937773002089 substrate binding site [chemical binding]; other site 937773002090 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 937773002091 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 937773002092 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 937773002093 Coenzyme A binding pocket [chemical binding]; other site 937773002094 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 937773002095 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 937773002096 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 937773002097 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 937773002098 active site 937773002099 substrate binding site [chemical binding]; other site 937773002100 metal binding site [ion binding]; metal-binding site 937773002101 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 937773002102 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773002103 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 937773002104 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773002105 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 937773002106 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 937773002107 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 937773002108 active site 937773002109 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 937773002110 ABC-2 type transporter; Region: ABC2_membrane; cl11417 937773002111 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 937773002112 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 937773002113 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 937773002114 Walker A/P-loop; other site 937773002115 ATP binding site [chemical binding]; other site 937773002116 Q-loop/lid; other site 937773002117 ABC transporter signature motif; other site 937773002118 Walker B; other site 937773002119 D-loop; other site 937773002120 H-loop/switch region; other site 937773002121 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 937773002122 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 937773002123 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 937773002124 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 937773002125 active site 937773002126 tetramer interface [polypeptide binding]; other site 937773002127 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 937773002128 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 937773002129 Subunit I/III interface [polypeptide binding]; other site 937773002130 Subunit III/IV interface [polypeptide binding]; other site 937773002131 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 937773002132 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 937773002133 D-pathway; other site 937773002134 Putative ubiquinol binding site [chemical binding]; other site 937773002135 Low-spin heme (heme b) binding site [chemical binding]; other site 937773002136 Putative water exit pathway; other site 937773002137 Binuclear center (heme o3/CuB) [ion binding]; other site 937773002138 K-pathway; other site 937773002139 Putative proton exit pathway; other site 937773002140 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 937773002141 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 937773002142 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 937773002143 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 937773002144 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 937773002145 heme-binding site [chemical binding]; other site 937773002146 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 937773002147 FAD binding pocket [chemical binding]; other site 937773002148 FAD binding motif [chemical binding]; other site 937773002149 phosphate binding motif [ion binding]; other site 937773002150 beta-alpha-beta structure motif; other site 937773002151 NAD binding pocket [chemical binding]; other site 937773002152 Heme binding pocket [chemical binding]; other site 937773002153 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175 937773002154 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 937773002155 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 937773002156 homodimer interface [polypeptide binding]; other site 937773002157 NADP binding site [chemical binding]; other site 937773002158 substrate binding site [chemical binding]; other site 937773002159 AIR carboxylase; Region: AIRC; cl00310 937773002160 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 937773002161 ATP-grasp domain; Region: ATP-grasp_4; cl03087 937773002162 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 937773002163 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 937773002164 ATP binding site [chemical binding]; other site 937773002165 active site 937773002166 substrate binding site [chemical binding]; other site 937773002167 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 937773002168 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 937773002169 putative active site [active] 937773002170 catalytic triad [active] 937773002171 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 937773002172 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 937773002173 dimerization interface [polypeptide binding]; other site 937773002174 ATP binding site [chemical binding]; other site 937773002175 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 937773002176 dimerization interface [polypeptide binding]; other site 937773002177 ATP binding site [chemical binding]; other site 937773002178 amidophosphoribosyltransferase; Provisional; Region: PRK07272 937773002179 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 937773002180 active site 937773002181 tetramer interface [polypeptide binding]; other site 937773002182 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 937773002183 active site 937773002184 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 937773002185 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 937773002186 dimerization interface [polypeptide binding]; other site 937773002187 putative ATP binding site [chemical binding]; other site 937773002188 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 937773002189 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 937773002190 active site 937773002191 substrate binding site [chemical binding]; other site 937773002192 cosubstrate binding site; other site 937773002193 catalytic site [active] 937773002194 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 937773002195 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 937773002196 purine monophosphate binding site [chemical binding]; other site 937773002197 dimer interface [polypeptide binding]; other site 937773002198 putative catalytic residues [active] 937773002199 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 937773002200 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 937773002201 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 937773002202 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790 937773002203 ATP-grasp domain; Region: ATP-grasp_4; cl03087 937773002204 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 937773002205 Cobalt transport protein; Region: CbiQ; cl00463 937773002206 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 937773002207 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 937773002208 Walker A/P-loop; other site 937773002209 ATP binding site [chemical binding]; other site 937773002210 Q-loop/lid; other site 937773002211 ABC transporter signature motif; other site 937773002212 Walker B; other site 937773002213 D-loop; other site 937773002214 H-loop/switch region; other site 937773002215 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 937773002216 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 937773002217 Walker A/P-loop; other site 937773002218 ATP binding site [chemical binding]; other site 937773002219 Q-loop/lid; other site 937773002220 ABC transporter signature motif; other site 937773002221 Walker B; other site 937773002222 D-loop; other site 937773002223 H-loop/switch region; other site 937773002224 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 937773002225 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 937773002226 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 937773002227 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 937773002228 dimerization domain swap beta strand [polypeptide binding]; other site 937773002229 regulatory protein interface [polypeptide binding]; other site 937773002230 active site 937773002231 regulatory phosphorylation site [posttranslational modification]; other site 937773002232 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 937773002233 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 937773002234 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 937773002235 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 937773002236 Transposase; Region: DEDD_Tnp_IS110; pfam01548 937773002237 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 937773002238 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 937773002239 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 937773002240 catalytic residues [active] 937773002241 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 937773002242 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 937773002243 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 937773002244 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773002245 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 937773002246 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 937773002247 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 937773002248 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 937773002249 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 937773002250 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 937773002251 active site 937773002252 catalytic residues [active] 937773002253 metal binding site [ion binding]; metal-binding site 937773002254 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 937773002255 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 937773002256 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 937773002257 TPP-binding site [chemical binding]; other site 937773002258 tetramer interface [polypeptide binding]; other site 937773002259 heterodimer interface [polypeptide binding]; other site 937773002260 phosphorylation loop region [posttranslational modification] 937773002261 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 937773002262 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 937773002263 alpha subunit interface [polypeptide binding]; other site 937773002264 TPP binding site [chemical binding]; other site 937773002265 heterodimer interface [polypeptide binding]; other site 937773002266 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 937773002267 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 937773002268 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 937773002269 E3 interaction surface; other site 937773002270 lipoyl attachment site [posttranslational modification]; other site 937773002271 e3 binding domain; Region: E3_binding; pfam02817 937773002272 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 937773002273 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 937773002274 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773002275 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 937773002276 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 937773002277 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 937773002278 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 937773002279 non-specific DNA binding site [nucleotide binding]; other site 937773002280 salt bridge; other site 937773002281 sequence-specific DNA binding site [nucleotide binding]; other site 937773002282 Cupin domain; Region: Cupin_2; cl09118 937773002283 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 937773002284 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773002285 Walker A/P-loop; other site 937773002286 ATP binding site [chemical binding]; other site 937773002287 Q-loop/lid; other site 937773002288 ABC transporter signature motif; other site 937773002289 Walker B; other site 937773002290 D-loop; other site 937773002291 H-loop/switch region; other site 937773002292 TOBE domain; Region: TOBE_2; cl01440 937773002293 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 937773002294 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 937773002295 dimer interface [polypeptide binding]; other site 937773002296 conserved gate region; other site 937773002297 putative PBP binding loops; other site 937773002298 ABC-ATPase subunit interface; other site 937773002299 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 937773002300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 937773002301 ABC-ATPase subunit interface; other site 937773002302 putative PBP binding loops; other site 937773002303 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 937773002304 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 937773002305 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 937773002306 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 937773002307 Protein of unknown function (DUF1054); Region: DUF1054; cl11544 937773002308 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 937773002309 active site 937773002310 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 937773002311 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 937773002312 G1 box; other site 937773002313 putative GEF interaction site [polypeptide binding]; other site 937773002314 GTP/Mg2+ binding site [chemical binding]; other site 937773002315 Switch I region; other site 937773002316 G2 box; other site 937773002317 G3 box; other site 937773002318 Switch II region; other site 937773002319 G4 box; other site 937773002320 G5 box; other site 937773002321 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 937773002322 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 937773002323 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 937773002324 putative active site [active] 937773002325 putative FMN binding site [chemical binding]; other site 937773002326 putative substrate binding site [chemical binding]; other site 937773002327 putative catalytic residue [active] 937773002328 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; cl11558 937773002329 Protein of unknown function (DUF1507); Region: DUF1507; cl11487 937773002330 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 937773002331 pyruvate carboxylase; Reviewed; Region: PRK12999 937773002332 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 937773002333 ATP-grasp domain; Region: ATP-grasp_4; cl03087 937773002334 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 937773002335 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 937773002336 active site 937773002337 catalytic residues [active] 937773002338 metal binding site [ion binding]; metal-binding site 937773002339 homodimer binding site [polypeptide binding]; other site 937773002340 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 937773002341 carboxyltransferase (CT) interaction site; other site 937773002342 biotinylation site [posttranslational modification]; other site 937773002343 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 937773002344 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 937773002345 UbiA prenyltransferase family; Region: UbiA; cl00337 937773002346 Protein of unknown function (DUF420); Region: DUF420; cl00989 937773002347 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 937773002348 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 937773002349 Protein of unknown function (DUF964); Region: DUF964; cl01483 937773002350 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 937773002351 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 937773002352 putative active site [active] 937773002353 catalytic site [active] 937773002354 putative metal binding site [ion binding]; other site 937773002355 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 937773002356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 937773002357 S-adenosylmethionine binding site [chemical binding]; other site 937773002358 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 937773002359 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 937773002360 active site 937773002361 (T/H)XGH motif; other site 937773002362 hypothetical protein; Provisional; Region: PRK13670 937773002363 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 937773002364 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 937773002365 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 937773002366 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 937773002367 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 937773002368 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 937773002369 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 937773002370 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 937773002371 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 937773002372 dimer interface [polypeptide binding]; other site 937773002373 motif 1; other site 937773002374 active site 937773002375 motif 2; other site 937773002376 motif 3; other site 937773002377 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 937773002378 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 937773002379 putative tRNA-binding site [nucleotide binding]; other site 937773002380 B3/4 domain; Region: B3_4; cl11458 937773002381 tRNA synthetase B5 domain; Region: B5; cl08394 937773002382 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 937773002383 dimer interface [polypeptide binding]; other site 937773002384 motif 1; other site 937773002385 motif 3; other site 937773002386 motif 2; other site 937773002387 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 937773002388 Alkylmercury lyase; Region: MerB; pfam03243 937773002389 ribonuclease HIII; Provisional; Region: PRK00996 937773002390 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 937773002391 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 937773002392 RNA/DNA hybrid binding site [nucleotide binding]; other site 937773002393 active site 937773002394 Cell division protein ZapA; Region: ZapA; cl01146 937773002395 Colicin V production protein; Region: Colicin_V; cl00567 937773002396 hypothetical protein; Provisional; Region: PRK08609 937773002397 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 937773002398 active site 937773002399 primer binding site [nucleotide binding]; other site 937773002400 NTP binding site [chemical binding]; other site 937773002401 metal binding triad [ion binding]; metal-binding site 937773002402 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 937773002403 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 937773002404 Walker A/P-loop; other site 937773002405 ATP binding site [chemical binding]; other site 937773002406 Q-loop/lid; other site 937773002407 ABC transporter signature motif; other site 937773002408 Walker B; other site 937773002409 D-loop; other site 937773002410 H-loop/switch region; other site 937773002411 Smr domain; Region: Smr; cl02619 937773002412 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 937773002413 catalytic residues [active] 937773002414 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 937773002415 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 937773002416 GIY-YIG motif/motif A; other site 937773002417 active site 937773002418 catalytic site [active] 937773002419 putative DNA binding site [nucleotide binding]; other site 937773002420 metal binding site [ion binding]; metal-binding site 937773002421 UvrB/uvrC motif; Region: UVR; pfam02151 937773002422 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 937773002423 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 937773002424 putative Iron-sulfur protein interface [polypeptide binding]; other site 937773002425 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 937773002426 proximal heme binding site [chemical binding]; other site 937773002427 distal heme binding site [chemical binding]; other site 937773002428 putative dimer interface [polypeptide binding]; other site 937773002429 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 937773002430 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773002431 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 937773002432 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 937773002433 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 937773002434 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 937773002435 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 937773002436 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 937773002437 active site 937773002438 dimerization interface [polypeptide binding]; other site 937773002439 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 937773002440 active site 937773002441 metal binding site [ion binding]; metal-binding site 937773002442 homotetramer interface [polypeptide binding]; other site 937773002443 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 937773002444 catalytic residues [active] 937773002445 catalytic nucleophile [active] 937773002446 Presynaptic Site I dimer interface [polypeptide binding]; other site 937773002447 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 937773002448 Synaptic Flat tetramer interface [polypeptide binding]; other site 937773002449 Synaptic Site I dimer interface [polypeptide binding]; other site 937773002450 DNA binding site [nucleotide binding] 937773002451 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 937773002452 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 937773002453 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 937773002454 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 937773002455 metal-binding site [ion binding] 937773002456 Ferritin-like domain; Region: Ferritin; pfam00210 937773002457 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 937773002458 dimerization interface [polypeptide binding]; other site 937773002459 DPS ferroxidase diiron center [ion binding]; other site 937773002460 ion pore; other site 937773002461 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 937773002462 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 937773002463 ligand binding site [chemical binding]; other site 937773002464 flexible hinge region; other site 937773002465 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 937773002466 putative switch regulator; other site 937773002467 non-specific DNA interactions [nucleotide binding]; other site 937773002468 DNA binding site [nucleotide binding] 937773002469 sequence specific DNA binding site [nucleotide binding]; other site 937773002470 putative cAMP binding site [chemical binding]; other site 937773002471 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 937773002472 Integrase core domain; Region: rve; cl01316 937773002473 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 937773002474 dimer interface [polypeptide binding]; other site 937773002475 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 937773002476 Cation transport protein; Region: TrkH; cl10514 937773002477 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 937773002478 dUMP phosphatase; Provisional; Region: PRK09449 937773002479 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 937773002480 motif II; other site 937773002481 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 937773002482 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 937773002483 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 937773002484 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 937773002485 MraZ protein; Region: MraZ; pfam02381 937773002486 MraZ protein; Region: MraZ; pfam02381 937773002487 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 937773002488 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773002489 Septum formation initiator; Region: DivIC; cl11433 937773002490 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 937773002491 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 937773002492 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 937773002493 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 937773002494 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 937773002495 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 937773002496 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 937773002497 Mg++ binding site [ion binding]; other site 937773002498 putative catalytic motif [active] 937773002499 putative substrate binding site [chemical binding]; other site 937773002500 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773002501 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 937773002502 NAD(P) binding pocket [chemical binding]; other site 937773002503 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 937773002504 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 937773002505 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 937773002506 Cell division protein FtsQ; Region: FtsQ; pfam03799 937773002507 cell division protein FtsA; Region: ftsA; TIGR01174 937773002508 Cell division protein FtsA; Region: FtsA; cl11496 937773002509 Cell division protein FtsA; Region: FtsA; cl11496 937773002510 cell division protein FtsZ; Validated; Region: PRK09330 937773002511 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 937773002512 nucleotide binding site [chemical binding]; other site 937773002513 SulA interaction site; other site 937773002514 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 937773002515 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 937773002516 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 937773002517 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 937773002518 catalytic residue [active] 937773002519 Protein of unknown function (DUF552); Region: DUF552; cl00775 937773002520 YGGT family; Region: YGGT; cl00508 937773002521 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 937773002522 Sugar transport protein; Region: Sugar_transport; pfam06800 937773002523 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 937773002524 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 937773002525 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 937773002526 putative active site [active] 937773002527 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 937773002528 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 937773002529 catalytic residue [active] 937773002530 Sodium:solute symporter family; Region: SSF; cl00456 937773002531 Domain of unknown function (DUF386); Region: DUF386; cl01047 937773002532 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 937773002533 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 937773002534 DivIVA protein; Region: DivIVA; pfam05103 937773002535 DivIVA domain; Region: DivI1A_domain; TIGR03544 937773002536 Plant ATP synthase F0; Region: YMF19; cl07975 937773002537 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 937773002538 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 937773002539 HIGH motif; other site 937773002540 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 937773002541 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 937773002542 active site 937773002543 KMSKS motif; other site 937773002544 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 937773002545 tRNA binding surface [nucleotide binding]; other site 937773002546 anticodon binding site; other site 937773002547 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 937773002548 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 937773002549 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 937773002550 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 937773002551 RNA binding surface [nucleotide binding]; other site 937773002552 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 937773002553 active site 937773002554 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 937773002555 active site 937773002556 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 937773002557 uracil transporter; Provisional; Region: PRK10720 937773002558 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 937773002559 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 937773002560 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773002561 dihydroorotase; Validated; Region: pyrC; PRK09357 937773002562 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 937773002563 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 937773002564 active site 937773002565 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 937773002566 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 937773002567 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 937773002568 catalytic site [active] 937773002569 subunit interface [polypeptide binding]; other site 937773002570 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 937773002571 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 937773002572 ATP-grasp domain; Region: ATP-grasp_4; cl03087 937773002573 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 937773002574 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 937773002575 ATP-grasp domain; Region: ATP-grasp_4; cl03087 937773002576 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 937773002577 IMP binding site; other site 937773002578 dimer interface [polypeptide binding]; other site 937773002579 interdomain contacts; other site 937773002580 partial ornithine binding site; other site 937773002581 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 937773002582 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 937773002583 FAD binding pocket [chemical binding]; other site 937773002584 FAD binding motif [chemical binding]; other site 937773002585 phosphate binding motif [ion binding]; other site 937773002586 beta-alpha-beta structure motif; other site 937773002587 NAD binding pocket [chemical binding]; other site 937773002588 Iron coordination center [ion binding]; other site 937773002589 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 937773002590 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 937773002591 heterodimer interface [polypeptide binding]; other site 937773002592 active site 937773002593 FMN binding site [chemical binding]; other site 937773002594 homodimer interface [polypeptide binding]; other site 937773002595 substrate binding site [chemical binding]; other site 937773002596 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 937773002597 active site 937773002598 dimer interface [polypeptide binding]; other site 937773002599 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 937773002600 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 937773002601 active site 937773002602 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 937773002603 dimer interface [polypeptide binding]; other site 937773002604 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 937773002605 Domain of unknown function (DUF814); Region: DUF814; pfam05670 937773002606 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 937773002607 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 937773002608 catalytic site [active] 937773002609 G-X2-G-X-G-K; other site 937773002610 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 937773002611 Major Facilitator Superfamily; Region: MFS_1; pfam07690 937773002612 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 937773002613 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 937773002614 Flavoprotein; Region: Flavoprotein; cl08021 937773002615 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 937773002616 primosome assembly protein PriA; Validated; Region: PRK05580 937773002617 primosome assembly protein PriA; Validated; Region: PRK05580 937773002618 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 937773002619 ATP binding site [chemical binding]; other site 937773002620 putative Mg++ binding site [ion binding]; other site 937773002621 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 937773002622 nucleotide binding region [chemical binding]; other site 937773002623 ATP-binding site [chemical binding]; other site 937773002624 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 937773002625 active site 937773002626 catalytic residues [active] 937773002627 metal binding site [ion binding]; metal-binding site 937773002628 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 937773002629 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 937773002630 putative active site [active] 937773002631 substrate binding site [chemical binding]; other site 937773002632 putative cosubstrate binding site; other site 937773002633 catalytic site [active] 937773002634 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 937773002635 substrate binding site [chemical binding]; other site 937773002636 16S rRNA methyltransferase B; Provisional; Region: PRK14902 937773002637 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 937773002638 putative RNA binding site [nucleotide binding]; other site 937773002639 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 937773002640 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 937773002641 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 937773002642 FeS/SAM binding site; other site 937773002643 Protein phosphatase 2C; Region: PP2C; pfam00481 937773002644 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 937773002645 active site 937773002646 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 937773002647 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 937773002648 active site 937773002649 ATP binding site [chemical binding]; other site 937773002650 substrate binding site [chemical binding]; other site 937773002651 activation loop (A-loop); other site 937773002652 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 937773002653 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 937773002654 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 937773002655 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 937773002656 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 937773002657 Transposase; Region: DEDD_Tnp_IS110; pfam01548 937773002658 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 937773002659 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 937773002660 GTPase RsgA; Reviewed; Region: PRK00098 937773002661 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 937773002662 RNA binding site [nucleotide binding]; other site 937773002663 homodimer interface [polypeptide binding]; other site 937773002664 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 937773002665 GTPase/Zn-binding domain interface [polypeptide binding]; other site 937773002666 GTP/Mg2+ binding site [chemical binding]; other site 937773002667 G4 box; other site 937773002668 G5 box; other site 937773002669 G1 box; other site 937773002670 Switch I region; other site 937773002671 G2 box; other site 937773002672 G3 box; other site 937773002673 Switch II region; other site 937773002674 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 937773002675 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 937773002676 substrate binding site [chemical binding]; other site 937773002677 hexamer interface [polypeptide binding]; other site 937773002678 metal binding site [ion binding]; metal-binding site 937773002679 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 937773002680 Thiamine pyrophosphokinase; Region: TPK; cd07995 937773002681 active site 937773002682 dimerization interface [polypeptide binding]; other site 937773002683 thiamine binding site [chemical binding]; other site 937773002684 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 937773002685 Asp23 family; Region: Asp23; cl00574 937773002686 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 937773002687 DAK2 domain; Region: Dak2; cl03685 937773002688 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 937773002689 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 937773002690 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 937773002691 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 937773002692 putative L-serine binding site [chemical binding]; other site 937773002693 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 937773002694 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 937773002695 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 937773002696 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 937773002697 generic binding surface II; other site 937773002698 ssDNA binding site; other site 937773002699 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 937773002700 ATP binding site [chemical binding]; other site 937773002701 putative Mg++ binding site [ion binding]; other site 937773002702 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 937773002703 nucleotide binding region [chemical binding]; other site 937773002704 ATP-binding site [chemical binding]; other site 937773002705 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 937773002706 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 937773002707 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 937773002708 Acyl transferase domain; Region: Acyl_transf_1; cl08282 937773002709 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 937773002710 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 937773002711 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 937773002712 NAD(P) binding site [chemical binding]; other site 937773002713 homotetramer interface [polypeptide binding]; other site 937773002714 homodimer interface [polypeptide binding]; other site 937773002715 active site 937773002716 Phosphopantetheine attachment site; Region: PP-binding; cl09936 937773002717 ribonuclease III; Reviewed; Region: rnc; PRK00102 937773002718 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 937773002719 dimerization interface [polypeptide binding]; other site 937773002720 active site 937773002721 metal binding site [ion binding]; metal-binding site 937773002722 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 937773002723 dsRNA binding site [nucleotide binding]; other site 937773002724 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 937773002725 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 937773002726 Walker A/P-loop; other site 937773002727 ATP binding site [chemical binding]; other site 937773002728 Q-loop/lid; other site 937773002729 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 937773002730 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 937773002731 ABC transporter signature motif; other site 937773002732 Walker B; other site 937773002733 D-loop; other site 937773002734 H-loop/switch region; other site 937773002735 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 937773002736 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 937773002737 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 937773002738 P loop; other site 937773002739 GTP binding site [chemical binding]; other site 937773002740 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 937773002741 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 937773002742 signal recognition particle protein; Provisional; Region: PRK10867 937773002743 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 937773002744 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 937773002745 P loop; other site 937773002746 GTP binding site [chemical binding]; other site 937773002747 Signal peptide binding domain; Region: SRP_SPB; pfam02978 937773002748 putative transposase OrfB; Reviewed; Region: PHA02517 937773002749 HTH-like domain; Region: HTH_21; pfam13276 937773002750 Integrase core domain; Region: rve; cl01316 937773002751 Integrase core domain; Region: rve_3; cl15866 937773002752 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 937773002753 non-specific DNA binding site [nucleotide binding]; other site 937773002754 salt bridge; other site 937773002755 sequence-specific DNA binding site [nucleotide binding]; other site 937773002756 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 937773002757 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 937773002758 putative active site; other site 937773002759 putative metal binding residues [ion binding]; other site 937773002760 signature motif; other site 937773002761 putative triphosphate binding site [ion binding]; other site 937773002762 ATP-grasp domain; Region: ATP-grasp_4; cl03087 937773002763 ATP-grasp domain; Region: ATP-grasp_4; cl03087 937773002764 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773002765 Major Facilitator Superfamily; Region: MFS_1; pfam07690 937773002766 putative substrate translocation pore; other site 937773002767 H+ Antiporter protein; Region: 2A0121; TIGR00900 937773002768 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 937773002769 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 937773002770 RimM N-terminal domain; Region: RimM; pfam01782 937773002771 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 937773002772 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 937773002773 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 937773002774 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 937773002775 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 937773002776 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 937773002777 Signal peptide peptidase; Region: Peptidase_A22B; cl01342 937773002778 GtrA-like protein; Region: GtrA; cl00971 937773002779 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 937773002780 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 937773002781 GTP/Mg2+ binding site [chemical binding]; other site 937773002782 G4 box; other site 937773002783 G5 box; other site 937773002784 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 937773002785 G1 box; other site 937773002786 G1 box; other site 937773002787 GTP/Mg2+ binding site [chemical binding]; other site 937773002788 Switch I region; other site 937773002789 G2 box; other site 937773002790 G2 box; other site 937773002791 G3 box; other site 937773002792 G3 box; other site 937773002793 Switch II region; other site 937773002794 Switch II region; other site 937773002795 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 937773002796 RNA/DNA hybrid binding site [nucleotide binding]; other site 937773002797 active site 937773002798 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 937773002799 ATP-grasp domain; Region: ATP-grasp_4; cl03087 937773002800 CoA-ligase; Region: Ligase_CoA; cl02894 937773002801 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 937773002802 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773002803 CoA-ligase; Region: Ligase_CoA; cl02894 937773002804 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 937773002805 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 937773002806 DNA topoisomerase I; Validated; Region: PRK05582 937773002807 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 937773002808 active site 937773002809 interdomain interaction site; other site 937773002810 putative metal-binding site [ion binding]; other site 937773002811 nucleotide binding site [chemical binding]; other site 937773002812 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 937773002813 domain I; other site 937773002814 DNA binding groove [nucleotide binding] 937773002815 phosphate binding site [ion binding]; other site 937773002816 domain II; other site 937773002817 domain III; other site 937773002818 nucleotide binding site [chemical binding]; other site 937773002819 catalytic site [active] 937773002820 domain IV; other site 937773002821 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 937773002822 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 937773002823 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773002824 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 937773002825 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 937773002826 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 937773002827 DNA binding site [nucleotide binding] 937773002828 Int/Topo IB signature motif; other site 937773002829 active site 937773002830 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 937773002831 active site 937773002832 HslU subunit interaction site [polypeptide binding]; other site 937773002833 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 937773002834 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 937773002835 Walker A motif; other site 937773002836 ATP binding site [chemical binding]; other site 937773002837 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773002838 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 937773002839 transcriptional repressor CodY; Validated; Region: PRK04158 937773002840 CodY GAF-like domain; Region: CodY; pfam06018 937773002841 Helix-turn-helix domains; Region: HTH; cl00088 937773002842 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 937773002843 rRNA interaction site [nucleotide binding]; other site 937773002844 S8 interaction site; other site 937773002845 putative laminin-1 binding site; other site 937773002846 elongation factor Ts; Provisional; Region: tsf; PRK09377 937773002847 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 937773002848 Elongation factor TS; Region: EF_TS; pfam00889 937773002849 Elongation factor TS; Region: EF_TS; pfam00889 937773002850 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 937773002851 putative nucleotide binding site [chemical binding]; other site 937773002852 uridine monophosphate binding site [chemical binding]; other site 937773002853 homohexameric interface [polypeptide binding]; other site 937773002854 ribosome recycling factor; Reviewed; Region: frr; PRK00083 937773002855 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 937773002856 hinge region; other site 937773002857 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 937773002858 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 937773002859 catalytic residue [active] 937773002860 putative FPP diphosphate binding site; other site 937773002861 putative FPP binding hydrophobic cleft; other site 937773002862 dimer interface [polypeptide binding]; other site 937773002863 putative IPP diphosphate binding site; other site 937773002864 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 937773002865 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 937773002866 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 937773002867 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 937773002868 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 937773002869 RIP metalloprotease RseP; Region: TIGR00054 937773002870 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 937773002871 active site 937773002872 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 937773002873 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 937773002874 protein binding site [polypeptide binding]; other site 937773002875 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 937773002876 putative substrate binding region [chemical binding]; other site 937773002877 prolyl-tRNA synthetase; Provisional; Region: PRK09194 937773002878 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 937773002879 dimer interface [polypeptide binding]; other site 937773002880 motif 1; other site 937773002881 active site 937773002882 motif 2; other site 937773002883 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 937773002884 putative deacylase active site [active] 937773002885 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 937773002886 active site 937773002887 motif 3; other site 937773002888 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 937773002889 anticodon binding site; other site 937773002890 DNA polymerase III PolC; Validated; Region: polC; PRK00448 937773002891 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 937773002892 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 937773002893 generic binding surface II; other site 937773002894 generic binding surface I; other site 937773002895 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 937773002896 active site 937773002897 substrate binding site [chemical binding]; other site 937773002898 catalytic site [active] 937773002899 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 937773002900 ribosome maturation protein RimP; Reviewed; Region: PRK00092 937773002901 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 937773002902 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 937773002903 Sm1 motif; other site 937773002904 predicted subunit interaction site [polypeptide binding]; other site 937773002905 RNA binding pocket [nucleotide binding]; other site 937773002906 Sm2 motif; other site 937773002907 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 937773002908 NusA N-terminal domain; Region: NusA_N; pfam08529 937773002909 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 937773002910 RNA binding site [nucleotide binding]; other site 937773002911 homodimer interface [polypeptide binding]; other site 937773002912 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 937773002913 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 937773002914 G-X-X-G motif; other site 937773002915 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 937773002916 putative RNA binding cleft [nucleotide binding]; other site 937773002917 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 937773002918 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 937773002919 translation initiation factor IF-2; Region: IF-2; TIGR00487 937773002920 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 937773002921 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 937773002922 G1 box; other site 937773002923 putative GEF interaction site [polypeptide binding]; other site 937773002924 GTP/Mg2+ binding site [chemical binding]; other site 937773002925 Switch I region; other site 937773002926 G2 box; other site 937773002927 G3 box; other site 937773002928 Switch II region; other site 937773002929 G4 box; other site 937773002930 G5 box; other site 937773002931 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 937773002932 Translation-initiation factor 2; Region: IF-2; pfam11987 937773002933 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 937773002934 Ribosome-binding factor A; Region: RBFA; cl00542 937773002935 tRNA pseudouridine synthase B; Provisional; Region: PRK14123 937773002936 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 937773002937 RNA binding site [nucleotide binding]; other site 937773002938 active site 937773002939 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 937773002940 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 937773002941 active site 937773002942 Riboflavin kinase; Region: Flavokinase; cl03312 937773002943 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 937773002944 16S/18S rRNA binding site [nucleotide binding]; other site 937773002945 S13e-L30e interaction site [polypeptide binding]; other site 937773002946 25S rRNA binding site [nucleotide binding]; other site 937773002947 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 937773002948 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 937773002949 RNase E interface [polypeptide binding]; other site 937773002950 trimer interface [polypeptide binding]; other site 937773002951 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 937773002952 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 937773002953 RNase E interface [polypeptide binding]; other site 937773002954 trimer interface [polypeptide binding]; other site 937773002955 active site 937773002956 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 937773002957 putative nucleic acid binding region [nucleotide binding]; other site 937773002958 G-X-X-G motif; other site 937773002959 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 937773002960 RNA binding site [nucleotide binding]; other site 937773002961 domain interface; other site 937773002962 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 937773002963 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 937773002964 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 937773002965 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773002966 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 937773002967 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 937773002968 Helix-turn-helix domains; Region: HTH; cl00088 937773002969 UTRA domain; Region: UTRA; cl01230 937773002970 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 937773002971 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 937773002972 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 937773002973 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 937773002974 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 937773002975 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 937773002976 classical (c) SDRs; Region: SDR_c; cd05233 937773002977 NAD(P) binding site [chemical binding]; other site 937773002978 active site 937773002979 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 937773002980 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 937773002981 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 937773002982 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 937773002983 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 937773002984 putative MPT binding site; other site 937773002985 recombinase A; Provisional; Region: recA; PRK09354 937773002986 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 937773002987 hexamer interface [polypeptide binding]; other site 937773002988 Walker A motif; other site 937773002989 ATP binding site [chemical binding]; other site 937773002990 Walker B motif; other site 937773002991 phosphodiesterase; Provisional; Region: PRK12704 937773002992 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 937773002993 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 937773002994 dimerization interface [polypeptide binding]; other site 937773002995 putative DNA binding site [nucleotide binding]; other site 937773002996 putative Zn2+ binding site [ion binding]; other site 937773002997 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 937773002998 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 937773002999 metal-binding site [ion binding] 937773003000 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 937773003001 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 937773003002 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 937773003003 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 937773003004 putative active site [active] 937773003005 metal binding site [ion binding]; metal-binding site 937773003006 homodimer binding site [polypeptide binding]; other site 937773003007 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 937773003008 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 937773003009 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 937773003010 dimer interface [polypeptide binding]; other site 937773003011 PYR/PP interface [polypeptide binding]; other site 937773003012 TPP binding site [chemical binding]; other site 937773003013 substrate binding site [chemical binding]; other site 937773003014 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 937773003015 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 937773003016 TPP-binding site [chemical binding]; other site 937773003017 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 937773003018 Domain of unknown function DUF77; Region: DUF77; cl00307 937773003019 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 937773003020 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 937773003021 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 937773003022 FeS/SAM binding site; other site 937773003023 TRAM domain; Region: TRAM; cl01282 937773003024 Protein of unknown function (DUF964); Region: DUF964; cl01483 937773003025 Thiamine-precursor transporter protein (ThiW); Region: ThiW; cl01952 937773003026 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 937773003027 MutS domain I; Region: MutS_I; pfam01624 937773003028 MutS domain II; Region: MutS_II; pfam05188 937773003029 MutS family domain IV; Region: MutS_IV; pfam05190 937773003030 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 937773003031 Walker A/P-loop; other site 937773003032 ATP binding site [chemical binding]; other site 937773003033 Q-loop/lid; other site 937773003034 ABC transporter signature motif; other site 937773003035 Walker B; other site 937773003036 D-loop; other site 937773003037 H-loop/switch region; other site 937773003038 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 937773003039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 937773003040 ATP binding site [chemical binding]; other site 937773003041 Mg2+ binding site [ion binding]; other site 937773003042 G-X-G motif; other site 937773003043 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 937773003044 ATP binding site [chemical binding]; other site 937773003045 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 937773003046 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 937773003047 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 937773003048 putative dimer interface [polypeptide binding]; other site 937773003049 catalytic triad [active] 937773003050 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 937773003051 amphipathic channel; other site 937773003052 Asn-Pro-Ala signature motifs; other site 937773003053 glycerol kinase; Provisional; Region: glpK; PRK00047 937773003054 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 937773003055 N- and C-terminal domain interface [polypeptide binding]; other site 937773003056 active site 937773003057 MgATP binding site [chemical binding]; other site 937773003058 catalytic site [active] 937773003059 metal binding site [ion binding]; metal-binding site 937773003060 glycerol binding site [chemical binding]; other site 937773003061 homotetramer interface [polypeptide binding]; other site 937773003062 homodimer interface [polypeptide binding]; other site 937773003063 FBP binding site [chemical binding]; other site 937773003064 protein IIAGlc interface [polypeptide binding]; other site 937773003065 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 937773003066 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 937773003067 Sm1 motif; other site 937773003068 D3 - B interaction site; other site 937773003069 D1 - D2 interaction site; other site 937773003070 Hfq - Hfq interaction site; other site 937773003071 RNA binding pocket [nucleotide binding]; other site 937773003072 Sm2 motif; other site 937773003073 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773003074 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 937773003075 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 937773003076 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 937773003077 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 937773003078 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 937773003079 catalytic residues [active] 937773003080 dimer interface [polypeptide binding]; other site 937773003081 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 937773003082 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 937773003083 HflX GTPase family; Region: HflX; cd01878 937773003084 G1 box; other site 937773003085 GTP/Mg2+ binding site [chemical binding]; other site 937773003086 Switch I region; other site 937773003087 G2 box; other site 937773003088 G3 box; other site 937773003089 Switch II region; other site 937773003090 G4 box; other site 937773003091 G5 box; other site 937773003092 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 937773003093 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 937773003094 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 937773003095 catalytic residue [active] 937773003096 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 937773003097 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 937773003098 DNA binding residues [nucleotide binding] 937773003099 glutamine synthetase, type I; Region: GlnA; TIGR00653 937773003100 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 937773003101 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 937773003102 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 937773003103 Int/Topo IB signature motif; other site 937773003104 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 937773003105 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 937773003106 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 937773003107 active site 937773003108 catalytic site [active] 937773003109 Major Facilitator Superfamily; Region: MFS_1; pfam07690 937773003110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 937773003111 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 937773003112 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 937773003113 motif II; other site 937773003114 Staphylococcal nuclease homologues; Region: SNc; smart00318 937773003115 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 937773003116 Catalytic site; other site 937773003117 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 937773003118 Catalytic site; other site 937773003119 Helix-turn-helix domains; Region: HTH; cl00088 937773003120 aspartate kinase; Reviewed; Region: PRK09034 937773003121 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 937773003122 putative catalytic residues [active] 937773003123 putative nucleotide binding site [chemical binding]; other site 937773003124 putative aspartate binding site [chemical binding]; other site 937773003125 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 937773003126 allosteric regulatory residue; other site 937773003127 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 937773003128 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 937773003129 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773003130 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 937773003131 threonine synthase; Reviewed; Region: PRK06721 937773003132 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 937773003133 homodimer interface [polypeptide binding]; other site 937773003134 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773003135 catalytic residue [active] 937773003136 homoserine kinase; Provisional; Region: PRK01212 937773003137 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 937773003138 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 937773003139 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 937773003140 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 937773003141 motif II; other site 937773003142 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 937773003143 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 937773003144 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 937773003145 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 937773003146 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 937773003147 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 937773003148 active site 937773003149 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 937773003150 LexA repressor; Validated; Region: PRK00215 937773003151 Helix-turn-helix domains; Region: HTH; cl00088 937773003152 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 937773003153 Catalytic site [active] 937773003154 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 937773003155 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 937773003156 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 937773003157 TPP-binding site [chemical binding]; other site 937773003158 dimer interface [polypeptide binding]; other site 937773003159 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 937773003160 PYR/PP interface [polypeptide binding]; other site 937773003161 dimer interface [polypeptide binding]; other site 937773003162 TPP binding site [chemical binding]; other site 937773003163 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 937773003164 Uncharacterized protein family (UPF0154); Region: UPF0154; cl01536 937773003165 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 937773003166 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 937773003167 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 937773003168 active site 937773003169 metal binding site [ion binding]; metal-binding site 937773003170 DNA binding site [nucleotide binding] 937773003171 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 937773003172 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 937773003173 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 937773003174 Walker A/P-loop; other site 937773003175 ATP binding site [chemical binding]; other site 937773003176 Q-loop/lid; other site 937773003177 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 937773003178 ABC transporter signature motif; other site 937773003179 Walker B; other site 937773003180 D-loop; other site 937773003181 H-loop/switch region; other site 937773003182 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 937773003183 BCCT family transporter; Region: BCCT; cl00569 937773003184 aconitate hydratase; Validated; Region: PRK09277 937773003185 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 937773003186 substrate binding site [chemical binding]; other site 937773003187 ligand binding site [chemical binding]; other site 937773003188 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 937773003189 substrate binding site [chemical binding]; other site 937773003190 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 937773003191 active site 937773003192 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 937773003193 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 937773003194 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 937773003195 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 937773003196 ATP binding site [chemical binding]; other site 937773003197 Mg2+ binding site [ion binding]; other site 937773003198 G-X-G motif; other site 937773003199 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 937773003200 anchoring element; other site 937773003201 dimer interface [polypeptide binding]; other site 937773003202 ATP binding site [chemical binding]; other site 937773003203 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 937773003204 active site 937773003205 putative metal-binding site [ion binding]; other site 937773003206 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 937773003207 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 937773003208 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 937773003209 CAP-like domain; other site 937773003210 active site 937773003211 primary dimer interface [polypeptide binding]; other site 937773003212 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 937773003213 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 937773003214 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 937773003215 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 937773003216 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 937773003217 CAT RNA binding domain; Region: CAT_RBD; cl03904 937773003218 transcriptional antiterminator BglG; Provisional; Region: PRK09772 937773003219 PRD domain; Region: PRD; cl15445 937773003220 PRD domain; Region: PRD; cl15445 937773003221 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 937773003222 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 937773003223 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 937773003224 active site turn [active] 937773003225 phosphorylation site [posttranslational modification] 937773003226 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 937773003227 HPr interaction site; other site 937773003228 glycerol kinase (GK) interaction site [polypeptide binding]; other site 937773003229 active site 937773003230 phosphorylation site [posttranslational modification] 937773003231 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 937773003232 Predicted integral membrane protein [Function unknown]; Region: COG0392 937773003233 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 937773003234 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 937773003235 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 937773003236 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 937773003237 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 937773003238 active site 1 [active] 937773003239 dimer interface [polypeptide binding]; other site 937773003240 hexamer interface [polypeptide binding]; other site 937773003241 active site 2 [active] 937773003242 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 937773003243 DNA polymerase IV; Reviewed; Region: PRK03103 937773003244 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 937773003245 active site 937773003246 DNA binding site [nucleotide binding] 937773003247 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 937773003248 prephenate dehydrogenase; Validated; Region: PRK06545 937773003249 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773003250 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 937773003251 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 937773003252 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 937773003253 putative oligomer interface [polypeptide binding]; other site 937773003254 putative active site [active] 937773003255 metal binding site [ion binding]; metal-binding site 937773003256 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 937773003257 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 937773003258 oligoendopeptidase F; Region: pepF; TIGR00181 937773003259 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 937773003260 active site 937773003261 Zn binding site [ion binding]; other site 937773003262 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 937773003263 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 937773003264 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 937773003265 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 937773003266 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 937773003267 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 937773003268 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 937773003269 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 937773003270 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773003271 Walker A/P-loop; other site 937773003272 ATP binding site [chemical binding]; other site 937773003273 Q-loop/lid; other site 937773003274 ABC transporter signature motif; other site 937773003275 Walker B; other site 937773003276 D-loop; other site 937773003277 H-loop/switch region; other site 937773003278 ABC transporter; Region: ABC_tran_2; pfam12848 937773003279 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 937773003280 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 937773003281 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773003282 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 937773003283 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 937773003284 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 937773003285 dimer interface [polypeptide binding]; other site 937773003286 active site 937773003287 catalytic residue [active] 937773003288 dihydrodipicolinate reductase; Provisional; Region: PRK00048 937773003289 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773003290 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 937773003291 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 937773003292 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 937773003293 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 937773003294 trimer interface [polypeptide binding]; other site 937773003295 active site 937773003296 substrate binding site [chemical binding]; other site 937773003297 CoA binding site [chemical binding]; other site 937773003298 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 937773003299 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 937773003300 metal binding site [ion binding]; metal-binding site 937773003301 dimer interface [polypeptide binding]; other site 937773003302 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 937773003303 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 937773003304 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 937773003305 catalytic residue [active] 937773003306 diaminopimelate decarboxylase; Region: lysA; TIGR01048 937773003307 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 937773003308 active site 937773003309 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 937773003310 substrate binding site [chemical binding]; other site 937773003311 catalytic residues [active] 937773003312 dimer interface [polypeptide binding]; other site 937773003313 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 937773003314 DNA-binding site [nucleotide binding]; DNA binding site 937773003315 RNA-binding motif; other site 937773003316 Protein of unknown function (DUF1033); Region: DUF1033; cl11549 937773003317 Acylphosphatase; Region: Acylphosphatase; cl00551 937773003318 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 937773003319 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 937773003320 BCCT family transporter; Region: BCCT; cl00569 937773003321 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 937773003322 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 937773003323 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 937773003324 metal ion-dependent adhesion site (MIDAS); other site 937773003325 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 937773003326 Walker A motif; other site 937773003327 ATP binding site [chemical binding]; other site 937773003328 Walker B motif; other site 937773003329 arginine finger; other site 937773003330 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 937773003331 active site 937773003332 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 937773003333 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 937773003334 E3 interaction surface; other site 937773003335 lipoyl attachment site [posttranslational modification]; other site 937773003336 e3 binding domain; Region: E3_binding; pfam02817 937773003337 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 937773003338 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 937773003339 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 937773003340 TPP-binding site [chemical binding]; other site 937773003341 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 937773003342 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 937773003343 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 937773003344 dimer interface [polypeptide binding]; other site 937773003345 phosphorylation site [posttranslational modification] 937773003346 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 937773003347 ATP binding site [chemical binding]; other site 937773003348 Mg2+ binding site [ion binding]; other site 937773003349 G-X-G motif; other site 937773003350 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 937773003351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 937773003352 active site 937773003353 phosphorylation site [posttranslational modification] 937773003354 intermolecular recognition site; other site 937773003355 dimerization interface [polypeptide binding]; other site 937773003356 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 937773003357 DNA binding site [nucleotide binding] 937773003358 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 937773003359 active site 937773003360 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 937773003361 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 937773003362 active site 937773003363 homodimer interface [polypeptide binding]; other site 937773003364 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 937773003365 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 937773003366 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 937773003367 C-terminal peptidase (prc); Region: prc; TIGR00225 937773003368 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 937773003369 protein binding site [polypeptide binding]; other site 937773003370 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 937773003371 Catalytic dyad [active] 937773003372 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 937773003373 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 937773003374 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 937773003375 HPr interaction site; other site 937773003376 glycerol kinase (GK) interaction site [polypeptide binding]; other site 937773003377 active site 937773003378 phosphorylation site [posttranslational modification] 937773003379 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 937773003380 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 937773003381 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 937773003382 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 937773003383 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 937773003384 folate binding site [chemical binding]; other site 937773003385 NADP+ binding site [chemical binding]; other site 937773003386 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 937773003387 dimerization interface [polypeptide binding]; other site 937773003388 active site 937773003389 Disulphide isomerase; Region: Disulph_isomer; pfam06491 937773003390 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 937773003391 Virulence factor; Region: Virulence_fact; pfam13769 937773003392 HEAT repeats; Region: HEAT_2; pfam13646 937773003393 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 937773003394 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 937773003395 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 937773003396 RNA/DNA hybrid binding site [nucleotide binding]; other site 937773003397 active site 937773003398 5'-3' exonuclease; Region: 53EXOc; smart00475 937773003399 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 937773003400 active site 937773003401 metal binding site 1 [ion binding]; metal-binding site 937773003402 putative 5' ssDNA interaction site; other site 937773003403 metal binding site 3; metal-binding site 937773003404 metal binding site 2 [ion binding]; metal-binding site 937773003405 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 937773003406 putative DNA binding site [nucleotide binding]; other site 937773003407 putative metal binding site [ion binding]; other site 937773003408 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 937773003409 Dynamin family; Region: Dynamin_N; pfam00350 937773003410 G1 box; other site 937773003411 GTP/Mg2+ binding site [chemical binding]; other site 937773003412 G2 box; other site 937773003413 Switch I region; other site 937773003414 G3 box; other site 937773003415 Switch II region; other site 937773003416 G4 box; other site 937773003417 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773003418 GTP/Mg2+ binding site [chemical binding]; other site 937773003419 G5 box; other site 937773003420 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773003421 Dynamin family; Region: Dynamin_N; pfam00350 937773003422 G1 box; other site 937773003423 G1 box; other site 937773003424 GTP/Mg2+ binding site [chemical binding]; other site 937773003425 G2 box; other site 937773003426 Switch I region; other site 937773003427 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773003428 G3 box; other site 937773003429 Switch II region; other site 937773003430 GTP/Mg2+ binding site [chemical binding]; other site 937773003431 G4 box; other site 937773003432 G5 box; other site 937773003433 Predicted permeases [General function prediction only]; Region: RarD; COG2962 937773003434 EamA-like transporter family; Region: EamA; cl01037 937773003435 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 937773003436 THUMP domain; Region: THUMP; cl12076 937773003437 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773003438 cell division protein GpsB; Provisional; Region: PRK14127 937773003439 DivIVA domain; Region: DivI1A_domain; TIGR03544 937773003440 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 937773003441 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 937773003442 Recombination protein U; Region: RecU; cl01314 937773003443 Transglycosylase; Region: Transgly; cl07896 937773003444 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 937773003445 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 937773003446 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 937773003447 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 937773003448 minor groove reading motif; other site 937773003449 helix-hairpin-helix signature motif; other site 937773003450 substrate binding pocket [chemical binding]; other site 937773003451 active site 937773003452 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 937773003453 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 937773003454 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 937773003455 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 937773003456 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 937773003457 putative dimer interface [polypeptide binding]; other site 937773003458 putative anticodon binding site; other site 937773003459 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 937773003460 homodimer interface [polypeptide binding]; other site 937773003461 motif 1; other site 937773003462 motif 2; other site 937773003463 active site 937773003464 motif 3; other site 937773003465 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 937773003466 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 937773003467 active site 937773003468 substrate binding site [chemical binding]; other site 937773003469 catalytic site [active] 937773003470 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773003471 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773003472 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 937773003473 DNA-binding site [nucleotide binding]; DNA binding site 937773003474 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 937773003475 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 937773003476 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 937773003477 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 937773003478 active site 937773003479 NTP binding site [chemical binding]; other site 937773003480 metal binding triad [ion binding]; metal-binding site 937773003481 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 937773003482 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 937773003483 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 937773003484 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 937773003485 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 937773003486 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 937773003487 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 937773003488 Uncharacterized conserved protein [Function unknown]; Region: COG5582 937773003489 UPF0302 domain; Region: UPF0302; pfam08864 937773003490 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 937773003491 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 937773003492 binding surface 937773003493 TPR motif; other site 937773003494 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 937773003495 binding surface 937773003496 TPR motif; other site 937773003497 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 937773003498 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 937773003499 hinge; other site 937773003500 active site 937773003501 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 937773003502 active site 937773003503 dimer interface [polypeptide binding]; other site 937773003504 metal binding site [ion binding]; metal-binding site 937773003505 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 937773003506 Tetramer interface [polypeptide binding]; other site 937773003507 active site 937773003508 FMN-binding site [chemical binding]; other site 937773003509 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 937773003510 active site 937773003511 multimer interface [polypeptide binding]; other site 937773003512 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 937773003513 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 937773003514 substrate binding pocket [chemical binding]; other site 937773003515 chain length determination region; other site 937773003516 substrate-Mg2+ binding site; other site 937773003517 catalytic residues [active] 937773003518 aspartate-rich region 1; other site 937773003519 active site lid residues [active] 937773003520 aspartate-rich region 2; other site 937773003521 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 937773003522 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 937773003523 S-adenosylmethionine binding site [chemical binding]; other site 937773003524 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 937773003525 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 937773003526 IHF dimer interface [polypeptide binding]; other site 937773003527 IHF - DNA interface [nucleotide binding]; other site 937773003528 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 937773003529 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773003530 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 937773003531 GTP-binding protein Der; Reviewed; Region: PRK00093 937773003532 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 937773003533 G1 box; other site 937773003534 GTP/Mg2+ binding site [chemical binding]; other site 937773003535 Switch I region; other site 937773003536 G2 box; other site 937773003537 Switch II region; other site 937773003538 G3 box; other site 937773003539 G4 box; other site 937773003540 G5 box; other site 937773003541 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 937773003542 G1 box; other site 937773003543 GTP/Mg2+ binding site [chemical binding]; other site 937773003544 Switch I region; other site 937773003545 G2 box; other site 937773003546 G3 box; other site 937773003547 Switch II region; other site 937773003548 G4 box; other site 937773003549 G5 box; other site 937773003550 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 937773003551 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 937773003552 RNA binding site [nucleotide binding]; other site 937773003553 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 937773003554 RNA binding site [nucleotide binding]; other site 937773003555 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 937773003556 RNA binding site [nucleotide binding]; other site 937773003557 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 937773003558 RNA binding site [nucleotide binding]; other site 937773003559 cytidylate kinase; Provisional; Region: cmk; PRK00023 937773003560 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 937773003561 CMP-binding site; other site 937773003562 The sites determining sugar specificity; other site 937773003563 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 937773003564 active site 937773003565 homotetramer interface [polypeptide binding]; other site 937773003566 homodimer interface [polypeptide binding]; other site 937773003567 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 937773003568 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773003569 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 937773003570 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 937773003571 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 937773003572 ATP binding site [chemical binding]; other site 937773003573 putative Mg++ binding site [ion binding]; other site 937773003574 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 937773003575 nucleotide binding region [chemical binding]; other site 937773003576 ATP-binding site [chemical binding]; other site 937773003577 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 937773003578 Helix-turn-helix domains; Region: HTH; cl00088 937773003579 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 937773003580 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 937773003581 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 937773003582 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 937773003583 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 937773003584 dimerization interface [polypeptide binding]; other site 937773003585 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 937773003586 dimer interface [polypeptide binding]; other site 937773003587 phosphorylation site [posttranslational modification] 937773003588 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 937773003589 ATP binding site [chemical binding]; other site 937773003590 Mg2+ binding site [ion binding]; other site 937773003591 G-X-G motif; other site 937773003592 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 937773003593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 937773003594 active site 937773003595 phosphorylation site [posttranslational modification] 937773003596 intermolecular recognition site; other site 937773003597 dimerization interface [polypeptide binding]; other site 937773003598 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 937773003599 DNA binding site [nucleotide binding] 937773003600 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 937773003601 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 937773003602 RNA binding surface [nucleotide binding]; other site 937773003603 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 937773003604 active site 937773003605 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 937773003606 ScpA/B protein; Region: ScpA_ScpB; cl00598 937773003607 Domain of unknown function (DUF309); Region: DUF309; cl00667 937773003608 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 937773003609 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 937773003610 Int/Topo IB signature motif; other site 937773003611 active site 937773003612 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 937773003613 metal binding site 2 [ion binding]; metal-binding site 937773003614 putative DNA binding helix; other site 937773003615 metal binding site 1 [ion binding]; metal-binding site 937773003616 dimer interface [polypeptide binding]; other site 937773003617 structural Zn2+ binding site [ion binding]; other site 937773003618 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 937773003619 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 937773003620 dimer interface [polypeptide binding]; other site 937773003621 ADP-ribose binding site [chemical binding]; other site 937773003622 active site 937773003623 nudix motif; other site 937773003624 metal binding site [ion binding]; metal-binding site 937773003625 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 937773003626 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 937773003627 active site 937773003628 catalytic tetrad [active] 937773003629 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 937773003630 classical (c) SDRs; Region: SDR_c; cd05233 937773003631 NAD(P) binding site [chemical binding]; other site 937773003632 active site 937773003633 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773003634 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 937773003635 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 937773003636 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 937773003637 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 937773003638 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 937773003639 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 937773003640 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 937773003641 H+ Antiporter protein; Region: 2A0121; TIGR00900 937773003642 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773003643 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 937773003644 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 937773003645 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 937773003646 peptidase T-like protein; Region: PepT-like; TIGR01883 937773003647 metal binding site [ion binding]; metal-binding site 937773003648 putative dimer interface [polypeptide binding]; other site 937773003649 Predicted membrane protein [Function unknown]; Region: COG4129 937773003650 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 937773003651 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 937773003652 Disulphide isomerase; Region: Disulph_isomer; pfam06491 937773003653 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 937773003654 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 937773003655 E3 interaction surface; other site 937773003656 lipoyl attachment site [posttranslational modification]; other site 937773003657 e3 binding domain; Region: E3_binding; pfam02817 937773003658 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 937773003659 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 937773003660 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 937773003661 alpha subunit interface [polypeptide binding]; other site 937773003662 TPP binding site [chemical binding]; other site 937773003663 heterodimer interface [polypeptide binding]; other site 937773003664 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 937773003665 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 937773003666 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 937773003667 tetramer interface [polypeptide binding]; other site 937773003668 TPP-binding site [chemical binding]; other site 937773003669 heterodimer interface [polypeptide binding]; other site 937773003670 phosphorylation loop region [posttranslational modification] 937773003671 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 937773003672 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773003673 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 937773003674 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 937773003675 Acetokinase family; Region: Acetate_kinase; cl01029 937773003676 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 937773003677 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 937773003678 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 937773003679 Walker A/P-loop; other site 937773003680 ATP binding site [chemical binding]; other site 937773003681 Q-loop/lid; other site 937773003682 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 937773003683 ABC transporter signature motif; other site 937773003684 Walker B; other site 937773003685 D-loop; other site 937773003686 H-loop/switch region; other site 937773003687 arginine repressor; Provisional; Region: PRK04280 937773003688 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 937773003689 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 937773003690 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 937773003691 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 937773003692 TPP-binding site; other site 937773003693 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 937773003694 PYR/PP interface [polypeptide binding]; other site 937773003695 dimer interface [polypeptide binding]; other site 937773003696 TPP binding site [chemical binding]; other site 937773003697 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 937773003698 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 937773003699 substrate binding pocket [chemical binding]; other site 937773003700 chain length determination region; other site 937773003701 substrate-Mg2+ binding site; other site 937773003702 catalytic residues [active] 937773003703 aspartate-rich region 1; other site 937773003704 active site lid residues [active] 937773003705 aspartate-rich region 2; other site 937773003706 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 937773003707 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 937773003708 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 937773003709 generic binding surface II; other site 937773003710 generic binding surface I; other site 937773003711 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 937773003712 putative RNA binding site [nucleotide binding]; other site 937773003713 Asp23 family; Region: Asp23; cl00574 937773003714 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 937773003715 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 937773003716 ATP-grasp domain; Region: ATP-grasp_4; cl03087 937773003717 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 937773003718 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 937773003719 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 937773003720 carboxyltransferase (CT) interaction site; other site 937773003721 biotinylation site [posttranslational modification]; other site 937773003722 elongation factor P; Validated; Region: PRK00529 937773003723 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 937773003724 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 937773003725 RNA binding site [nucleotide binding]; other site 937773003726 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 937773003727 RNA binding site [nucleotide binding]; other site 937773003728 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 937773003729 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 937773003730 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 937773003731 active site 937773003732 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 937773003733 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 937773003734 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 937773003735 active site residue [active] 937773003736 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 937773003737 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 937773003738 tetramer interface [polypeptide binding]; other site 937773003739 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773003740 catalytic residue [active] 937773003741 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 937773003742 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 937773003743 tetramer interface [polypeptide binding]; other site 937773003744 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773003745 catalytic residue [active] 937773003746 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 937773003747 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 937773003748 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 937773003749 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 937773003750 ADP binding site [chemical binding]; other site 937773003751 magnesium binding site [ion binding]; other site 937773003752 putative shikimate binding site; other site 937773003753 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 937773003754 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 937773003755 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 937773003756 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 937773003757 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 937773003758 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773003759 ATP binding site [chemical binding]; other site 937773003760 Walker B motif; other site 937773003761 ParB-like nuclease domain; Region: ParBc; cl02129 937773003762 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 937773003763 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 937773003764 Active Sites [active] 937773003765 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 937773003766 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 937773003767 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 937773003768 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773003769 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 937773003770 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 937773003771 amidase catalytic site [active] 937773003772 Zn binding residues [ion binding]; other site 937773003773 substrate binding site [chemical binding]; other site 937773003774 Holin family; Region: Phage_holin_4; cl01989 937773003775 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 937773003776 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 937773003777 active site 937773003778 catalytic triad [active] 937773003779 oxyanion hole [active] 937773003780 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 937773003781 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 937773003782 active site 937773003783 oxyanion hole [active] 937773003784 catalytic triad [active] 937773003785 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 937773003786 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 937773003787 Phage tail protein; Region: Sipho_tail; pfam05709 937773003788 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 937773003789 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 937773003790 Mitochondrial inner membrane protein; Region: Mitofilin; pfam09731 937773003791 Peptidase family M23; Region: Peptidase_M23; pfam01551 937773003792 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 937773003793 N-acetyl-D-glucosamine binding site [chemical binding]; other site 937773003794 catalytic residue [active] 937773003795 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 937773003796 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 937773003797 Phage capsid family; Region: Phage_capsid; pfam05065 937773003798 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 937773003799 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 937773003800 oligomer interface [polypeptide binding]; other site 937773003801 active site residues [active] 937773003802 Phage-related protein [Function unknown]; Region: COG4695; cl01923 937773003803 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 937773003804 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 937773003805 Phage Terminase; Region: Terminase_1; pfam03354 937773003806 Phage terminase, small subunit; Region: Terminase_4; cl01525 937773003807 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 937773003808 YopX protein; Region: YopX; cl09859 937773003809 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 937773003810 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 937773003811 Walker A motif; other site 937773003812 ATP binding site [chemical binding]; other site 937773003813 Walker B motif; other site 937773003814 arginine finger; other site 937773003815 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 937773003816 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 937773003817 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 937773003818 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 937773003819 dimer interface [polypeptide binding]; other site 937773003820 ssDNA binding site [nucleotide binding]; other site 937773003821 tetramer (dimer of dimers) interface [polypeptide binding]; other site 937773003822 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 937773003823 RecT family; Region: RecT; cl04285 937773003824 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 937773003825 non-specific DNA binding site [nucleotide binding]; other site 937773003826 salt bridge; other site 937773003827 sequence-specific DNA binding site [nucleotide binding]; other site 937773003828 AAA domain; Region: AAA_23; pfam13476 937773003829 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 937773003830 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 937773003831 Hypothetical protein of unknown function (DUF2482); Region: DUF2482; pfam10655 937773003832 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 937773003833 non-specific DNA binding site [nucleotide binding]; other site 937773003834 salt bridge; other site 937773003835 sequence-specific DNA binding site [nucleotide binding]; other site 937773003836 Domain of unknown function (DUF955); Region: DUF955; cl01076 937773003837 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 937773003838 Int/Topo IB signature motif; other site 937773003839 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773003840 Walker A motif; other site 937773003841 ATP binding site [chemical binding]; other site 937773003842 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 937773003843 Domain of unknown function DUF77; Region: DUF77; cl00307 937773003844 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 937773003845 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 937773003846 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 937773003847 Rhomboid family; Region: Rhomboid; cl11446 937773003848 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 937773003849 binding surface 937773003850 TPR motif; other site 937773003851 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 937773003852 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 937773003853 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 937773003854 PhoU domain; Region: PhoU; pfam01895 937773003855 PhoU domain; Region: PhoU; pfam01895 937773003856 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 937773003857 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 937773003858 Walker A/P-loop; other site 937773003859 ATP binding site [chemical binding]; other site 937773003860 Q-loop/lid; other site 937773003861 ABC transporter signature motif; other site 937773003862 Walker B; other site 937773003863 D-loop; other site 937773003864 H-loop/switch region; other site 937773003865 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 937773003866 dimer interface [polypeptide binding]; other site 937773003867 conserved gate region; other site 937773003868 putative PBP binding loops; other site 937773003869 ABC-ATPase subunit interface; other site 937773003870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 937773003871 dimer interface [polypeptide binding]; other site 937773003872 conserved gate region; other site 937773003873 putative PBP binding loops; other site 937773003874 ABC-ATPase subunit interface; other site 937773003875 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 937773003876 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 937773003877 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 937773003878 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 937773003879 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 937773003880 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 937773003881 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 937773003882 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 937773003883 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 937773003884 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 937773003885 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 937773003886 Transposase; Region: DDE_Tnp_ISL3; pfam01610 937773003887 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 937773003888 metal binding site 2 [ion binding]; metal-binding site 937773003889 putative DNA binding helix; other site 937773003890 metal binding site 1 [ion binding]; metal-binding site 937773003891 dimer interface [polypeptide binding]; other site 937773003892 structural Zn2+ binding site [ion binding]; other site 937773003893 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 937773003894 ABC-ATPase subunit interface; other site 937773003895 dimer interface [polypeptide binding]; other site 937773003896 putative PBP binding regions; other site 937773003897 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 937773003898 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 937773003899 endonuclease IV; Provisional; Region: PRK01060 937773003900 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 937773003901 AP (apurinic/apyrimidinic) site pocket; other site 937773003902 DNA interaction; other site 937773003903 Metal-binding active site; metal-binding site 937773003904 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 937773003905 DEAD-like helicases superfamily; Region: DEXDc; smart00487 937773003906 ATP binding site [chemical binding]; other site 937773003907 Mg++ binding site [ion binding]; other site 937773003908 motif III; other site 937773003909 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 937773003910 nucleotide binding region [chemical binding]; other site 937773003911 ATP-binding site [chemical binding]; other site 937773003912 LytB protein; Region: LYTB; cl00507 937773003913 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 937773003914 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 937773003915 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 937773003916 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 937773003917 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773003918 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 937773003919 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 937773003920 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 937773003921 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 937773003922 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 937773003923 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 937773003924 DNA binding residues [nucleotide binding] 937773003925 DNA primase, catalytic core; Region: dnaG; TIGR01391 937773003926 CHC2 zinc finger; Region: zf-CHC2; cl15369 937773003927 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 937773003928 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 937773003929 active site 937773003930 metal binding site [ion binding]; metal-binding site 937773003931 interdomain interaction site; other site 937773003932 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 937773003933 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 937773003934 FOG: CBS domain [General function prediction only]; Region: COG0517 937773003935 glycyl-tRNA synthetase; Provisional; Region: PRK04173 937773003936 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 937773003937 motif 1; other site 937773003938 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774 937773003939 active site 937773003940 motif 2; other site 937773003941 motif 3; other site 937773003942 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 937773003943 anticodon binding site; other site 937773003944 Recombination protein O N terminal; Region: RecO_N; cl15812 937773003945 DNA repair protein RecO; Region: reco; TIGR00613 937773003946 Recombination protein O C terminal; Region: RecO_C; pfam02565 937773003947 GTPase Era; Reviewed; Region: era; PRK00089 937773003948 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 937773003949 G1 box; other site 937773003950 GTP/Mg2+ binding site [chemical binding]; other site 937773003951 Switch I region; other site 937773003952 G2 box; other site 937773003953 Switch II region; other site 937773003954 G3 box; other site 937773003955 G4 box; other site 937773003956 G5 box; other site 937773003957 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 937773003958 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 937773003959 active site 937773003960 catalytic motif [active] 937773003961 Zn binding site [ion binding]; other site 937773003962 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 937773003963 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 937773003964 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773003965 peptide chain release factor 1; Region: prfA; TIGR00019 937773003966 SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057 937773003967 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 937773003968 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 937773003969 radical SAM methylthiotransferase, MiaB/RimO family; Region: TIGR00089 937773003970 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 937773003971 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 937773003972 FeS/SAM binding site; other site 937773003973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 937773003974 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 937773003975 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 937773003976 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 937773003977 S-adenosylmethionine binding site [chemical binding]; other site 937773003978 chaperone protein DnaJ; Provisional; Region: PRK14280 937773003979 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 937773003980 HSP70 interaction site [polypeptide binding]; other site 937773003981 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 937773003982 substrate binding site [polypeptide binding]; other site 937773003983 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 937773003984 Zn binding sites [ion binding]; other site 937773003985 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 937773003986 dimer interface [polypeptide binding]; other site 937773003987 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 937773003988 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 937773003989 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 937773003990 dimer interface [polypeptide binding]; other site 937773003991 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 937773003992 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 937773003993 Helix-turn-helix domains; Region: HTH; cl00088 937773003994 HrcA protein C terminal domain; Region: HrcA; pfam01628 937773003995 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 937773003996 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 937773003997 FeS/SAM binding site; other site 937773003998 HemN C-terminal domain; Region: HemN_C; pfam06969 937773003999 GTP-binding protein LepA; Provisional; Region: PRK05433 937773004000 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 937773004001 G1 box; other site 937773004002 putative GEF interaction site [polypeptide binding]; other site 937773004003 GTP/Mg2+ binding site [chemical binding]; other site 937773004004 Switch I region; other site 937773004005 G2 box; other site 937773004006 G3 box; other site 937773004007 Switch II region; other site 937773004008 G4 box; other site 937773004009 G5 box; other site 937773004010 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 937773004011 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 937773004012 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 937773004013 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 937773004014 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 937773004015 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 937773004016 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 937773004017 Competence protein; Region: Competence; cl00471 937773004018 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 937773004019 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 937773004020 catalytic motif [active] 937773004021 Zn binding site [ion binding]; other site 937773004022 SLBB domain; Region: SLBB; pfam10531 937773004023 comEA protein; Region: comE; TIGR01259 937773004024 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 937773004025 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 937773004026 S-adenosylmethionine binding site [chemical binding]; other site 937773004027 Oligomerisation domain; Region: Oligomerisation; cl00519 937773004028 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 937773004029 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 937773004030 Zn2+ binding site [ion binding]; other site 937773004031 Mg2+ binding site [ion binding]; other site 937773004032 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 937773004033 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 937773004034 active site 937773004035 (T/H)XGH motif; other site 937773004036 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 937773004037 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 937773004038 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 937773004039 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 937773004040 shikimate binding site; other site 937773004041 NAD(P) binding site [chemical binding]; other site 937773004042 GTPase YqeH; Provisional; Region: PRK13796 937773004043 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 937773004044 GTP/Mg2+ binding site [chemical binding]; other site 937773004045 G4 box; other site 937773004046 G5 box; other site 937773004047 G1 box; other site 937773004048 Switch I region; other site 937773004049 G2 box; other site 937773004050 G3 box; other site 937773004051 Switch II region; other site 937773004052 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 937773004053 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 937773004054 active site 937773004055 motif I; other site 937773004056 motif II; other site 937773004057 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 937773004058 5'-methylthioadenosine nucleosidase; Region: PLN02584 937773004059 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 937773004060 LamB/YcsF family; Region: LamB_YcsF; cl00664 937773004061 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 937773004062 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 937773004063 ATP-grasp domain; Region: ATP-grasp_4; cl03087 937773004064 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 937773004065 acetyl-CoA carboxylase, biotin carboxyl carrier protein; Region: BCCP; TIGR00531 937773004066 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 937773004067 carboxyltransferase (CT) interaction site; other site 937773004068 biotinylation site [posttranslational modification]; other site 937773004069 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 937773004070 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 937773004071 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 937773004072 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 937773004073 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 937773004074 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 937773004075 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 937773004076 Sugar specificity; other site 937773004077 Pyrimidine base specificity; other site 937773004078 ATP-binding site [chemical binding]; other site 937773004079 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 937773004080 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 937773004081 Peptidase family U32; Region: Peptidase_U32; cl03113 937773004082 Peptidase family U32; Region: Peptidase_U32; cl03113 937773004083 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 937773004084 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 937773004085 S-adenosylmethionine binding site [chemical binding]; other site 937773004086 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 937773004087 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 937773004088 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 937773004089 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 937773004090 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 937773004091 motif 1; other site 937773004092 active site 937773004093 motif 2; other site 937773004094 motif 3; other site 937773004095 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 937773004096 DHHA1 domain; Region: DHHA1; pfam02272 937773004097 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 937773004098 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773004099 Family description; Region: UvrD_C_2; cl15862 937773004100 TPR repeat; Region: TPR_11; pfam13414 937773004101 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 937773004102 binding surface 937773004103 TPR motif; other site 937773004104 TPR repeat; Region: TPR_11; pfam13414 937773004105 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 937773004106 binding surface 937773004107 TPR motif; other site 937773004108 TPR repeat; Region: TPR_11; pfam13414 937773004109 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 937773004110 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 937773004111 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 937773004112 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 937773004113 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 937773004114 catalytic residue [active] 937773004115 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 937773004116 CsbD-like; Region: CsbD; cl15799 937773004117 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 937773004118 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 937773004119 active site 937773004120 catalytic tetrad [active] 937773004121 Predicted transcriptional regulator [Transcription]; Region: COG1959 937773004122 Helix-turn-helix domains; Region: HTH; cl00088 937773004123 recombination factor protein RarA; Reviewed; Region: PRK13342 937773004124 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 937773004125 Walker A motif; other site 937773004126 ATP binding site [chemical binding]; other site 937773004127 Walker B motif; other site 937773004128 arginine finger; other site 937773004129 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 937773004130 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 937773004131 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 937773004132 putative ATP binding site [chemical binding]; other site 937773004133 putative substrate interface [chemical binding]; other site 937773004134 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 937773004135 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 937773004136 dimer interface [polypeptide binding]; other site 937773004137 anticodon binding site; other site 937773004138 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 937773004139 homodimer interface [polypeptide binding]; other site 937773004140 motif 1; other site 937773004141 active site 937773004142 motif 2; other site 937773004143 GAD domain; Region: GAD; pfam02938 937773004144 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 937773004145 motif 3; other site 937773004146 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 937773004147 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 937773004148 dimer interface [polypeptide binding]; other site 937773004149 motif 1; other site 937773004150 active site 937773004151 motif 2; other site 937773004152 motif 3; other site 937773004153 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 937773004154 anticodon binding site; other site 937773004155 Bacterial SH3 domain; Region: SH3_3; cl02551 937773004156 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 937773004157 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 937773004158 active site 937773004159 metal binding site [ion binding]; metal-binding site 937773004160 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 937773004161 putative active site [active] 937773004162 dimerization interface [polypeptide binding]; other site 937773004163 putative tRNAtyr binding site [nucleotide binding]; other site 937773004164 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 937773004165 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 937773004166 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 937773004167 synthetase active site [active] 937773004168 NTP binding site [chemical binding]; other site 937773004169 metal binding site [ion binding]; metal-binding site 937773004170 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 937773004171 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 937773004172 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 937773004173 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 937773004174 active site 937773004175 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 937773004176 DHH family; Region: DHH; pfam01368 937773004177 DHHA1 domain; Region: DHHA1; pfam02272 937773004178 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 937773004179 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 937773004180 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 937773004181 Protein export membrane protein; Region: SecD_SecF; cl14618 937773004182 Protein export membrane protein; Region: SecD_SecF; cl14618 937773004183 Preprotein translocase subunit; Region: YajC; cl00806 937773004184 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 937773004185 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 937773004186 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 937773004187 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 937773004188 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 937773004189 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 937773004190 Walker A motif; other site 937773004191 ATP binding site [chemical binding]; other site 937773004192 Walker B motif; other site 937773004193 arginine finger; other site 937773004194 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 937773004195 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 937773004196 RuvA N terminal domain; Region: RuvA_N; pfam01330 937773004197 hypothetical protein; Provisional; Region: PRK04435 937773004198 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 937773004199 GTPase CgtA; Reviewed; Region: obgE; PRK12297 937773004200 GTP1/OBG; Region: GTP1_OBG; pfam01018 937773004201 Obg GTPase; Region: Obg; cd01898 937773004202 G1 box; other site 937773004203 GTP/Mg2+ binding site [chemical binding]; other site 937773004204 Switch I region; other site 937773004205 G2 box; other site 937773004206 G3 box; other site 937773004207 Switch II region; other site 937773004208 G4 box; other site 937773004209 G5 box; other site 937773004210 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 937773004211 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 937773004212 Protein of unknown function (DUF464); Region: DUF464; cl01080 937773004213 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 937773004214 rod shape-determining protein MreD; Region: MreD; cl01087 937773004215 rod shape-determining protein MreC; Region: MreC; pfam04085 937773004216 hypothetical protein; Reviewed; Region: PRK00024 937773004217 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 937773004218 MPN+ (JAMM) motif; other site 937773004219 Zinc-binding site [ion binding]; other site 937773004220 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 937773004221 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 937773004222 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 937773004223 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 937773004224 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 937773004225 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 937773004226 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 937773004227 active site 937773004228 HIGH motif; other site 937773004229 nucleotide binding site [chemical binding]; other site 937773004230 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 937773004231 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 937773004232 active site 937773004233 KMSKS motif; other site 937773004234 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 937773004235 tRNA binding surface [nucleotide binding]; other site 937773004236 anticodon binding site; other site 937773004237 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 937773004238 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 937773004239 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 937773004240 Putative ammonia monooxygenase; Region: AmoA; pfam05145 937773004241 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 937773004242 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 937773004243 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 937773004244 inhibitor-cofactor binding pocket; inhibition site 937773004245 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773004246 catalytic residue [active] 937773004247 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 937773004248 dimer interface [polypeptide binding]; other site 937773004249 active site 937773004250 Schiff base residues; other site 937773004251 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 937773004252 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 937773004253 active site 937773004254 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 937773004255 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 937773004256 domain interfaces; other site 937773004257 active site 937773004258 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 937773004259 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 937773004260 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 937773004261 tRNA; other site 937773004262 putative tRNA binding site [nucleotide binding]; other site 937773004263 putative NADP binding site [chemical binding]; other site 937773004264 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 937773004265 Predicted GTPase [General function prediction only]; Region: COG0218 937773004266 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 937773004267 G1 box; other site 937773004268 GTP/Mg2+ binding site [chemical binding]; other site 937773004269 Switch I region; other site 937773004270 G2 box; other site 937773004271 G3 box; other site 937773004272 Switch II region; other site 937773004273 G4 box; other site 937773004274 G5 box; other site 937773004275 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 937773004276 Transposase; Region: DDE_Tnp_ISL3; pfam01610 937773004277 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 937773004278 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 937773004279 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 937773004280 Walker A motif; other site 937773004281 ATP binding site [chemical binding]; other site 937773004282 Walker B motif; other site 937773004283 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 937773004284 trigger factor; Provisional; Region: tig; PRK01490 937773004285 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 937773004286 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 937773004287 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 937773004288 nudix motif; other site 937773004289 ribosomal protein L20; Region: rpl20; CHL00068 937773004290 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 937773004291 23S rRNA binding site [nucleotide binding]; other site 937773004292 L21 binding site [polypeptide binding]; other site 937773004293 L13 binding site [polypeptide binding]; other site 937773004294 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 937773004295 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 937773004296 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 937773004297 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 937773004298 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 937773004299 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 937773004300 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 937773004301 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 937773004302 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 937773004303 active site 937773004304 dimer interface [polypeptide binding]; other site 937773004305 motif 1; other site 937773004306 motif 2; other site 937773004307 motif 3; other site 937773004308 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 937773004309 anticodon binding site; other site 937773004310 primosomal protein DnaI; Reviewed; Region: PRK08939 937773004311 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 937773004312 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 937773004313 Walker A motif; other site 937773004314 ATP binding site [chemical binding]; other site 937773004315 Walker B motif; other site 937773004316 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 937773004317 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 937773004318 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 937773004319 ATP cone domain; Region: ATP-cone; pfam03477 937773004320 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 937773004321 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773004322 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 937773004323 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 937773004324 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 937773004325 CoA-binding site [chemical binding]; other site 937773004326 ATP-binding [chemical binding]; other site 937773004327 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 937773004328 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 937773004329 DNA binding site [nucleotide binding] 937773004330 catalytic residue [active] 937773004331 H2TH interface [polypeptide binding]; other site 937773004332 putative catalytic residues [active] 937773004333 turnover-facilitating residue; other site 937773004334 intercalation triad [nucleotide binding]; other site 937773004335 8OG recognition residue [nucleotide binding]; other site 937773004336 putative reading head residues; other site 937773004337 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 937773004338 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 937773004339 DNA polymerase I; Provisional; Region: PRK05755 937773004340 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 937773004341 active site 937773004342 metal binding site 1 [ion binding]; metal-binding site 937773004343 putative 5' ssDNA interaction site; other site 937773004344 metal binding site 3; metal-binding site 937773004345 metal binding site 2 [ion binding]; metal-binding site 937773004346 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 937773004347 putative DNA binding site [nucleotide binding]; other site 937773004348 putative metal binding site [ion binding]; other site 937773004349 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 937773004350 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 937773004351 active site 937773004352 DNA binding site [nucleotide binding] 937773004353 catalytic site [active] 937773004354 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 937773004355 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 937773004356 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 937773004357 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 937773004358 dimer interface [polypeptide binding]; other site 937773004359 phosphorylation site [posttranslational modification] 937773004360 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 937773004361 ATP binding site [chemical binding]; other site 937773004362 Mg2+ binding site [ion binding]; other site 937773004363 G-X-G motif; other site 937773004364 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 937773004365 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 937773004366 active site 937773004367 phosphorylation site [posttranslational modification] 937773004368 intermolecular recognition site; other site 937773004369 dimerization interface [polypeptide binding]; other site 937773004370 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 937773004371 DNA binding site [nucleotide binding] 937773004372 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 937773004373 isocitrate dehydrogenase; Validated; Region: PRK07362 937773004374 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 937773004375 dimer interface [polypeptide binding]; other site 937773004376 Citrate synthase; Region: Citrate_synt; pfam00285 937773004377 active site 937773004378 citrylCoA binding site [chemical binding]; other site 937773004379 oxalacetate/citrate binding site [chemical binding]; other site 937773004380 coenzyme A binding site [chemical binding]; other site 937773004381 catalytic triad [active] 937773004382 pyruvate kinase; Provisional; Region: PRK06354 937773004383 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 937773004384 domain interfaces; other site 937773004385 active site 937773004386 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 937773004387 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 937773004388 active site 937773004389 ADP/pyrophosphate binding site [chemical binding]; other site 937773004390 dimerization interface [polypeptide binding]; other site 937773004391 allosteric effector site; other site 937773004392 fructose-1,6-bisphosphate binding site; other site 937773004393 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 937773004394 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 937773004395 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 937773004396 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 937773004397 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 937773004398 Malic enzyme, N-terminal domain; Region: malic; pfam00390 937773004399 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 937773004400 putative NAD(P) binding site [chemical binding]; other site 937773004401 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 937773004402 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 937773004403 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 937773004404 generic binding surface I; other site 937773004405 generic binding surface II; other site 937773004406 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 937773004407 DHH family; Region: DHH; pfam01368 937773004408 DHHA1 domain; Region: DHHA1; pfam02272 937773004409 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 937773004410 Helix-turn-helix domains; Region: HTH; cl00088 937773004411 DNA-binding site [nucleotide binding]; DNA binding site 937773004412 DRTGG domain; Region: DRTGG; cl12147 937773004413 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 937773004414 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 937773004415 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 937773004416 Ligand Binding Site [chemical binding]; other site 937773004417 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 937773004418 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 937773004419 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 937773004420 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 937773004421 active site 937773004422 CutC family; Region: CutC; cl01218 937773004423 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 937773004424 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 937773004425 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773004426 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 937773004427 Ligand Binding Site [chemical binding]; other site 937773004428 Acetokinase family; Region: Acetate_kinase; cl01029 937773004429 propionate/acetate kinase; Provisional; Region: PRK12379 937773004430 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 937773004431 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 937773004432 S-adenosylmethionine binding site [chemical binding]; other site 937773004433 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 937773004434 dimer interface [polypeptide binding]; other site 937773004435 catalytic triad [active] 937773004436 peroxidatic and resolving cysteines [active] 937773004437 RDD family; Region: RDD; cl00746 937773004438 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 937773004439 tandem repeat interface [polypeptide binding]; other site 937773004440 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 937773004441 oligomer interface [polypeptide binding]; other site 937773004442 active site residues [active] 937773004443 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 937773004444 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 937773004445 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 937773004446 THUMP domain; Region: THUMP; cl12076 937773004447 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 937773004448 Ligand Binding Site [chemical binding]; other site 937773004449 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 937773004450 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 937773004451 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 937773004452 catalytic residue [active] 937773004453 septation ring formation regulator EzrA; Provisional; Region: PRK04778 937773004454 GAF domain; Region: GAF; cl15785 937773004455 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 937773004456 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 937773004457 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 937773004458 RNA binding surface [nucleotide binding]; other site 937773004459 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 937773004460 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 937773004461 Sm1 motif; other site 937773004462 RNA binding pocket [nucleotide binding]; other site 937773004463 aldose dehydrogenase; Validated; Region: PRK06398 937773004464 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 937773004465 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 937773004466 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 937773004467 Phosphotransferase enzyme family; Region: APH; pfam01636 937773004468 active site 937773004469 ATP binding site [chemical binding]; other site 937773004470 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 937773004471 active site 937773004472 ATP binding site [chemical binding]; other site 937773004473 substrate binding site [chemical binding]; other site 937773004474 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 937773004475 Coenzyme A binding pocket [chemical binding]; other site 937773004476 Predicted acetyltransferase [General function prediction only]; Region: COG3393 937773004477 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 937773004478 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 937773004479 MAP domain; Region: MAP; pfam03642 937773004480 MAP domain; Region: MAP; pfam03642 937773004481 ornithine cyclodeaminase; Validated; Region: PRK08618 937773004482 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773004483 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 937773004484 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 937773004485 active site 937773004486 catalytic site [active] 937773004487 OsmC-like protein; Region: OsmC; cl00767 937773004488 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 937773004489 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 937773004490 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 937773004491 catalytic residue [active] 937773004492 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 937773004493 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773004494 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 937773004495 putative L-serine binding site [chemical binding]; other site 937773004496 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 937773004497 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 937773004498 motif II; other site 937773004499 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 937773004500 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 937773004501 putative acyl-acceptor binding pocket; other site 937773004502 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 937773004503 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 937773004504 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 937773004505 protein binding site [polypeptide binding]; other site 937773004506 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 937773004507 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 937773004508 active site 937773004509 HIGH motif; other site 937773004510 dimer interface [polypeptide binding]; other site 937773004511 KMSKS motif; other site 937773004512 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 937773004513 RNA binding surface [nucleotide binding]; other site 937773004514 Transglycosylase; Region: Transgly; cl07896 937773004515 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 937773004516 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 937773004517 Potassium binding sites [ion binding]; other site 937773004518 Cesium cation binding sites [ion binding]; other site 937773004519 acetyl-CoA synthetase; Provisional; Region: PRK04319 937773004520 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 937773004521 AMP-binding enzyme; Region: AMP-binding; cl15778 937773004522 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 937773004523 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 937773004524 Coenzyme A binding pocket [chemical binding]; other site 937773004525 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 937773004526 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 937773004527 catabolite control protein A; Region: ccpA; TIGR01481 937773004528 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 937773004529 DNA binding site [nucleotide binding] 937773004530 domain linker motif; other site 937773004531 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 937773004532 dimerization interface [polypeptide binding]; other site 937773004533 effector binding site; other site 937773004534 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 937773004535 Chorismate mutase type II; Region: CM_2; cl00693 937773004536 NeuB family; Region: NeuB; cl00496 937773004537 YtxH-like protein; Region: YtxH; cl02079 937773004538 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 937773004539 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 937773004540 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 937773004541 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 937773004542 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 937773004543 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773004544 HerA helicase [Replication, recombination, and repair]; Region: COG0433 937773004545 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 937773004546 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 937773004547 putative tRNA-binding site [nucleotide binding]; other site 937773004548 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 937773004549 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 937773004550 catalytic residues [active] 937773004551 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 937773004552 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 937773004553 oligomer interface [polypeptide binding]; other site 937773004554 active site 937773004555 metal binding site [ion binding]; metal-binding site 937773004556 Predicted small secreted protein [Function unknown]; Region: COG5584 937773004557 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 937773004558 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 937773004559 S-adenosylmethionine binding site [chemical binding]; other site 937773004560 Phosphotransferase enzyme family; Region: APH; pfam01636 937773004561 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 937773004562 active site 937773004563 substrate binding site [chemical binding]; other site 937773004564 ATP binding site [chemical binding]; other site 937773004565 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 937773004566 homodimer interface [polypeptide binding]; other site 937773004567 substrate-cofactor binding pocket; other site 937773004568 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773004569 catalytic residue [active] 937773004570 dipeptidase PepV; Reviewed; Region: PRK07318 937773004571 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 937773004572 active site 937773004573 metal binding site [ion binding]; metal-binding site 937773004574 YtxH-like protein; Region: YtxH; cl02079 937773004575 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 937773004576 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 937773004577 RNA binding surface [nucleotide binding]; other site 937773004578 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 937773004579 active site 937773004580 uracil binding [chemical binding]; other site 937773004581 stage V sporulation protein B; Region: spore_V_B; TIGR02900 937773004582 MatE; Region: MatE; cl10513 937773004583 HI0933-like protein; Region: HI0933_like; pfam03486 937773004584 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773004585 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 937773004586 active site residue [active] 937773004587 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 937773004588 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 937773004589 HIGH motif; other site 937773004590 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 937773004591 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 937773004592 active site 937773004593 KMSKS motif; other site 937773004594 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 937773004595 tRNA binding surface [nucleotide binding]; other site 937773004596 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773004597 Major Facilitator Superfamily; Region: MFS_1; pfam07690 937773004598 putative substrate translocation pore; other site 937773004599 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 937773004600 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773004601 Methyltransferase domain; Region: Methyltransf_31; pfam13847 937773004602 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773004603 Helix-turn-helix domains; Region: HTH; cl00088 937773004604 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 937773004605 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 937773004606 tetramer (dimer of dimers) interface [polypeptide binding]; other site 937773004607 NAD binding site [chemical binding]; other site 937773004608 dimer interface [polypeptide binding]; other site 937773004609 substrate binding site [chemical binding]; other site 937773004610 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 937773004611 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 937773004612 Proline dehydrogenase; Region: Pro_dh; cl03282 937773004613 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 937773004614 homopentamer interface [polypeptide binding]; other site 937773004615 active site 937773004616 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 937773004617 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 937773004618 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 937773004619 dimerization interface [polypeptide binding]; other site 937773004620 active site 937773004621 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 937773004622 Lumazine binding domain; Region: Lum_binding; pfam00677 937773004623 Lumazine binding domain; Region: Lum_binding; pfam00677 937773004624 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 937773004625 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 937773004626 catalytic motif [active] 937773004627 Zn binding site [ion binding]; other site 937773004628 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 937773004629 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 937773004630 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773004631 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 937773004632 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 937773004633 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 937773004634 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 937773004635 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 937773004636 active site 937773004637 intersubunit interactions; other site 937773004638 catalytic residue [active] 937773004639 CrcB-like protein; Region: CRCB; cl09114 937773004640 CrcB-like protein; Region: CRCB; cl09114 937773004641 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 937773004642 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 937773004643 active site 937773004644 catalytic tetrad [active] 937773004645 S-adenosylmethionine synthetase; Validated; Region: PRK05250 937773004646 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 937773004647 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 937773004648 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 937773004649 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 937773004650 active site 937773004651 substrate-binding site [chemical binding]; other site 937773004652 metal-binding site [ion binding] 937773004653 ATP binding site [chemical binding]; other site 937773004654 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 937773004655 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 937773004656 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 937773004657 nudix motif; other site 937773004658 Haemolytic domain; Region: Haemolytic; cl00506 937773004659 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 937773004660 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 937773004661 metal binding site [ion binding]; metal-binding site 937773004662 substrate binding pocket [chemical binding]; other site 937773004663 AMP-binding enzyme; Region: AMP-binding; cl15778 937773004664 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 937773004665 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 937773004666 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 937773004667 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 937773004668 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 937773004669 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 937773004670 intersubunit interface [polypeptide binding]; other site 937773004671 active site 937773004672 Zn2+ binding site [ion binding]; other site 937773004673 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 937773004674 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 937773004675 AP (apurinic/apyrimidinic) site pocket; other site 937773004676 DNA interaction; other site 937773004677 Metal-binding active site; metal-binding site 937773004678 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 937773004679 active site 937773004680 dimer interface [polypeptide binding]; other site 937773004681 magnesium binding site [ion binding]; other site 937773004682 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 937773004683 active site 937773004684 phosphorylation site [posttranslational modification] 937773004685 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 937773004686 P-loop; other site 937773004687 active site 937773004688 phosphorylation site [posttranslational modification] 937773004689 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 937773004690 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 937773004691 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 937773004692 catalytic core [active] 937773004693 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 937773004694 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 937773004695 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 937773004696 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 937773004697 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 937773004698 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 937773004699 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 937773004700 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 937773004701 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773004702 ferrochelatase; Provisional; Region: PRK12435 937773004703 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 937773004704 C-terminal domain interface [polypeptide binding]; other site 937773004705 active site 937773004706 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 937773004707 active site 937773004708 N-terminal domain interface [polypeptide binding]; other site 937773004709 methyltransferase, MtaA/CmuA family; Region: mtaA_cmuA; TIGR01463 937773004710 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 937773004711 substrate binding site [chemical binding]; other site 937773004712 active site 937773004713 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 937773004714 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 937773004715 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 937773004716 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 937773004717 Walker A/P-loop; other site 937773004718 ATP binding site [chemical binding]; other site 937773004719 Q-loop/lid; other site 937773004720 ABC transporter signature motif; other site 937773004721 Walker B; other site 937773004722 D-loop; other site 937773004723 H-loop/switch region; other site 937773004724 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 937773004725 HIT family signature motif; other site 937773004726 catalytic residue [active] 937773004727 YtxH-like protein; Region: YtxH; cl02079 937773004728 transcriptional regulator Hpr; Provisional; Region: PRK13777 937773004729 Helix-turn-helix domains; Region: HTH; cl00088 937773004730 Helix-turn-helix domains; Region: HTH; cl00088 937773004731 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 937773004732 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 937773004733 PPIC-type PPIASE domain; Region: Rotamase; cl08278 937773004734 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 937773004735 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 937773004736 generic binding surface II; other site 937773004737 generic binding surface I; other site 937773004738 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 937773004739 Uncharacterized conserved protein [Function unknown]; Region: COG4717 937773004740 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 937773004741 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 937773004742 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 937773004743 active site 937773004744 metal binding site [ion binding]; metal-binding site 937773004745 DNA binding site [nucleotide binding] 937773004746 Protein of unknown function (DUF964); Region: DUF964; cl01483 937773004747 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 937773004748 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 937773004749 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 937773004750 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 937773004751 Cation efflux family; Region: Cation_efflux; cl00316 937773004752 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 937773004753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 937773004754 active site 937773004755 phosphorylation site [posttranslational modification] 937773004756 intermolecular recognition site; other site 937773004757 dimerization interface [polypeptide binding]; other site 937773004758 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 937773004759 DNA binding residues [nucleotide binding] 937773004760 dimerization interface [polypeptide binding]; other site 937773004761 GAF domain; Region: GAF_2; pfam13185 937773004762 GAF domain; Region: GAF; cl15785 937773004763 Histidine kinase; Region: HisKA_3; pfam07730 937773004764 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 937773004765 ATP binding site [chemical binding]; other site 937773004766 Mg2+ binding site [ion binding]; other site 937773004767 G-X-G motif; other site 937773004768 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 937773004769 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 937773004770 active site 937773004771 polyphosphate kinase; Provisional; Region: PRK05443 937773004772 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 937773004773 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 937773004774 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 937773004775 putative domain interface [polypeptide binding]; other site 937773004776 putative active site [active] 937773004777 catalytic site [active] 937773004778 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 937773004779 putative domain interface [polypeptide binding]; other site 937773004780 putative active site [active] 937773004781 catalytic site [active] 937773004782 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 937773004783 fumarate hydratase; Reviewed; Region: fumC; PRK00485 937773004784 Class II fumarases; Region: Fumarase_classII; cd01362 937773004785 active site 937773004786 tetramer interface [polypeptide binding]; other site 937773004787 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 937773004788 active site 937773004789 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 937773004790 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 937773004791 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 937773004792 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 937773004793 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 937773004794 Walker A/P-loop; other site 937773004795 ATP binding site [chemical binding]; other site 937773004796 Q-loop/lid; other site 937773004797 ABC transporter signature motif; other site 937773004798 Walker B; other site 937773004799 D-loop; other site 937773004800 H-loop/switch region; other site 937773004801 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 937773004802 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 937773004803 substrate binding pocket [chemical binding]; other site 937773004804 membrane-bound complex binding site; other site 937773004805 hinge residues; other site 937773004806 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 937773004807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 937773004808 dimer interface [polypeptide binding]; other site 937773004809 conserved gate region; other site 937773004810 ABC-ATPase subunit interface; other site 937773004811 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 937773004812 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 937773004813 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 937773004814 ferric uptake regulator; Provisional; Region: fur; PRK09462 937773004815 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 937773004816 metal binding site 2 [ion binding]; metal-binding site 937773004817 putative DNA binding helix; other site 937773004818 metal binding site 1 [ion binding]; metal-binding site 937773004819 dimer interface [polypeptide binding]; other site 937773004820 structural Zn2+ binding site [ion binding]; other site 937773004821 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 937773004822 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773004823 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 937773004824 catalytic triad [active] 937773004825 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 937773004826 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 937773004827 inhibitor-cofactor binding pocket; inhibition site 937773004828 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773004829 catalytic residue [active] 937773004830 Predicted membrane protein [Function unknown]; Region: COG4129 937773004831 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 937773004832 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 937773004833 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 937773004834 active site 937773004835 FMN binding site [chemical binding]; other site 937773004836 substrate binding site [chemical binding]; other site 937773004837 3Fe-4S cluster binding site [ion binding]; other site 937773004838 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 937773004839 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 937773004840 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 937773004841 Walker A/P-loop; other site 937773004842 ATP binding site [chemical binding]; other site 937773004843 Q-loop/lid; other site 937773004844 ABC transporter signature motif; other site 937773004845 Walker B; other site 937773004846 D-loop; other site 937773004847 H-loop/switch region; other site 937773004848 Protein of unknown function (DUF402); Region: DUF402; cl00979 937773004849 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 937773004850 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 937773004851 minor groove reading motif; other site 937773004852 helix-hairpin-helix signature motif; other site 937773004853 substrate binding pocket [chemical binding]; other site 937773004854 active site 937773004855 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 937773004856 DNA binding and oxoG recognition site [nucleotide binding] 937773004857 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 937773004858 ABC-2 type transporter; Region: ABC2_membrane; cl11417 937773004859 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 937773004860 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773004861 Walker A/P-loop; other site 937773004862 ATP binding site [chemical binding]; other site 937773004863 ABC transporter signature motif; other site 937773004864 Walker B; other site 937773004865 D-loop; other site 937773004866 H-loop/switch region; other site 937773004867 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 937773004868 RecX family; Region: RecX; cl00936 937773004869 Transglycosylase; Region: Transgly; cl07896 937773004870 pyruvate oxidase; Provisional; Region: PRK08611 937773004871 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 937773004872 PYR/PP interface [polypeptide binding]; other site 937773004873 tetramer interface [polypeptide binding]; other site 937773004874 dimer interface [polypeptide binding]; other site 937773004875 TPP binding site [chemical binding]; other site 937773004876 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 937773004877 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 937773004878 TPP-binding site [chemical binding]; other site 937773004879 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 937773004880 intracellular protease, PfpI family; Region: PfpI; TIGR01382 937773004881 proposed catalytic triad [active] 937773004882 conserved cys residue [active] 937773004883 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 937773004884 FeS/SAM binding site; other site 937773004885 YfkB-like domain; Region: YfkB; pfam08756 937773004886 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 937773004887 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 937773004888 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 937773004889 Low molecular weight phosphatase family; Region: LMWPc; cd00115 937773004890 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 937773004891 active site 937773004892 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 937773004893 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 937773004894 active site clefts [active] 937773004895 zinc binding site [ion binding]; other site 937773004896 dimer interface [polypeptide binding]; other site 937773004897 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 937773004898 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 937773004899 active site 937773004900 phosphorylation site [posttranslational modification] 937773004901 intermolecular recognition site; other site 937773004902 dimerization interface [polypeptide binding]; other site 937773004903 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 937773004904 DNA binding residues [nucleotide binding] 937773004905 dimerization interface [polypeptide binding]; other site 937773004906 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 937773004907 Histidine kinase; Region: HisKA_3; pfam07730 937773004908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 937773004909 ATP binding site [chemical binding]; other site 937773004910 Mg2+ binding site [ion binding]; other site 937773004911 G-X-G motif; other site 937773004912 Predicted membrane protein [Function unknown]; Region: COG4758 937773004913 SdpI/YhfL protein family; Region: SdpI; pfam13630 937773004914 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 937773004915 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 937773004916 active site 937773004917 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 937773004918 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 937773004919 catalytic triad [active] 937773004920 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 937773004921 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 937773004922 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 937773004923 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 937773004924 Ferritin-like domain; Region: Ferritin; pfam00210 937773004925 ferroxidase diiron center [ion binding]; other site 937773004926 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 937773004927 Transposase; Region: DDE_Tnp_ISL3; pfam01610 937773004928 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 937773004929 active site 937773004930 substrate binding site [chemical binding]; other site 937773004931 catalytic site [active] 937773004932 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 937773004933 active site 937773004934 DNA polymerase IV; Validated; Region: PRK02406 937773004935 DNA binding site [nucleotide binding] 937773004936 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 937773004937 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 937773004938 Radical SAM superfamily; Region: Radical_SAM; pfam04055 937773004939 FeS/SAM binding site; other site 937773004940 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 937773004941 TRAM domain; Region: TRAM; cl01282 937773004942 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 937773004943 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 937773004944 S-adenosylmethionine binding site [chemical binding]; other site 937773004945 putative lipid kinase; Reviewed; Region: PRK13337 937773004946 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 937773004947 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 937773004948 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 937773004949 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 937773004950 GatB domain; Region: GatB_Yqey; cl11497 937773004951 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 937773004952 Amidase; Region: Amidase; cl11426 937773004953 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 937773004954 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 937773004955 Sodium:solute symporter family; Region: SSF; cl00456 937773004956 CamS sex pheromone cAM373 precursor; Region: CamS; cl11554 937773004957 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 937773004958 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 937773004959 nucleotide binding pocket [chemical binding]; other site 937773004960 K-X-D-G motif; other site 937773004961 catalytic site [active] 937773004962 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 937773004963 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 937773004964 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 937773004965 Dimer interface [polypeptide binding]; other site 937773004966 BRCT sequence motif; other site 937773004967 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 937773004968 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773004969 Family description; Region: UvrD_C_2; cl15862 937773004970 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 937773004971 substrate binding site [chemical binding]; other site 937773004972 putative active site [active] 937773004973 dimer interface [polypeptide binding]; other site 937773004974 Helix-turn-helix domains; Region: HTH; cl00088 937773004975 adenylosuccinate lyase; Provisional; Region: PRK07492 937773004976 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 937773004977 tetramer interface [polypeptide binding]; other site 937773004978 active site 937773004979 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 937773004980 NETI protein; Region: NETI; pfam14044 937773004981 hypothetical protein; Provisional; Region: PRK04164 937773004982 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 937773004983 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 937773004984 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 937773004985 homodimer interface [polypeptide binding]; other site 937773004986 NAD binding pocket [chemical binding]; other site 937773004987 ATP binding pocket [chemical binding]; other site 937773004988 Mg binding site [ion binding]; other site 937773004989 active-site loop [active] 937773004990 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 937773004991 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 937773004992 active site 937773004993 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 937773004994 active site 937773004995 dimer interface [polypeptide binding]; other site 937773004996 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 937773004997 Prephenate dehydratase; Region: PDT; pfam00800 937773004998 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 937773004999 putative L-Phe binding site [chemical binding]; other site 937773005000 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 937773005001 Isochorismatase family; Region: Isochorismatase; pfam00857 937773005002 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 937773005003 catalytic triad [active] 937773005004 conserved cis-peptide bond; other site 937773005005 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 937773005006 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 937773005007 DHHA2 domain; Region: DHHA2; pfam02833 937773005008 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 937773005009 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 937773005010 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 937773005011 NAD(P) binding site [chemical binding]; other site 937773005012 catalytic residues [active] 937773005013 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 937773005014 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 937773005015 active site 937773005016 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 937773005017 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 937773005018 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 937773005019 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 937773005020 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 937773005021 gluconate transporter; Region: gntP; TIGR00791 937773005022 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 937773005023 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 937773005024 N- and C-terminal domain interface [polypeptide binding]; other site 937773005025 putative active site [active] 937773005026 catalytic site [active] 937773005027 metal binding site [ion binding]; metal-binding site 937773005028 carbohydrate binding site [chemical binding]; other site 937773005029 ATP binding site [chemical binding]; other site 937773005030 Transcriptional regulators [Transcription]; Region: GntR; COG1802 937773005031 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 937773005032 DNA-binding site [nucleotide binding]; DNA binding site 937773005033 FCD domain; Region: FCD; cl11656 937773005034 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 937773005035 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 937773005036 Walker A/P-loop; other site 937773005037 ATP binding site [chemical binding]; other site 937773005038 Q-loop/lid; other site 937773005039 ABC transporter signature motif; other site 937773005040 Walker B; other site 937773005041 D-loop; other site 937773005042 H-loop/switch region; other site 937773005043 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 937773005044 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 937773005045 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773005046 homodimer interface [polypeptide binding]; other site 937773005047 catalytic residue [active] 937773005048 Radical SAM superfamily; Region: Radical_SAM; pfam04055 937773005049 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 937773005050 FeS/SAM binding site; other site 937773005051 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 937773005052 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 937773005053 active site 937773005054 DNA binding site [nucleotide binding] 937773005055 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 937773005056 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 937773005057 metal binding site [ion binding]; metal-binding site 937773005058 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 937773005059 active site 937773005060 catalytic residues [active] 937773005061 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 937773005062 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 937773005063 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 937773005064 ring oligomerisation interface [polypeptide binding]; other site 937773005065 ATP/Mg binding site [chemical binding]; other site 937773005066 stacking interactions; other site 937773005067 hinge regions; other site 937773005068 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 937773005069 oligomerisation interface [polypeptide binding]; other site 937773005070 mobile loop; other site 937773005071 roof hairpin; other site 937773005072 CAAX protease self-immunity; Region: Abi; cl00558 937773005073 Predicted amidohydrolase [General function prediction only]; Region: COG0388 937773005074 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 937773005075 putative active site [active] 937773005076 catalytic triad [active] 937773005077 putative dimer interface [polypeptide binding]; other site 937773005078 Accessory gene regulator B; Region: AgrB; cl01873 937773005079 Staphylococcal AgrD protein; Region: AgrD; cl05477 937773005080 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 937773005081 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 937773005082 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 937773005083 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 937773005084 active site 937773005085 phosphorylation site [posttranslational modification] 937773005086 intermolecular recognition site; other site 937773005087 dimerization interface [polypeptide binding]; other site 937773005088 LytTr DNA-binding domain; Region: LytTR; cl04498 937773005089 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 937773005090 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 937773005091 putative substrate binding site [chemical binding]; other site 937773005092 putative ATP binding site [chemical binding]; other site 937773005093 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 937773005094 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 937773005095 substrate binding [chemical binding]; other site 937773005096 active site 937773005097 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 937773005098 Transcriptional regulators [Transcription]; Region: PurR; COG1609 937773005099 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 937773005100 DNA binding site [nucleotide binding] 937773005101 domain linker motif; other site 937773005102 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 937773005103 dimerization interface [polypeptide binding]; other site 937773005104 ligand binding site [chemical binding]; other site 937773005105 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 937773005106 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 937773005107 Helix-turn-helix domains; Region: HTH; cl00088 937773005108 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 937773005109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773005110 putative substrate translocation pore; other site 937773005111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773005112 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 937773005113 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 937773005114 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773005115 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 937773005116 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 937773005117 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 937773005118 ABC transporter; Region: ABC_tran_2; pfam12848 937773005119 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 937773005120 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 937773005121 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773005122 Walker A/P-loop; other site 937773005123 ATP binding site [chemical binding]; other site 937773005124 Q-loop/lid; other site 937773005125 ABC transporter signature motif; other site 937773005126 Walker B; other site 937773005127 D-loop; other site 937773005128 H-loop/switch region; other site 937773005129 UGMP family protein; Validated; Region: PRK09604 937773005130 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 937773005131 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 937773005132 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 937773005133 Coenzyme A binding pocket [chemical binding]; other site 937773005134 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 937773005135 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 937773005136 Dehydratase family; Region: ILVD_EDD; cl00340 937773005137 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 937773005138 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 937773005139 PYR/PP interface [polypeptide binding]; other site 937773005140 dimer interface [polypeptide binding]; other site 937773005141 TPP binding site [chemical binding]; other site 937773005142 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 937773005143 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 937773005144 TPP-binding site [chemical binding]; other site 937773005145 dimer interface [polypeptide binding]; other site 937773005146 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 937773005147 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 937773005148 ketol-acid reductoisomerase; Provisional; Region: PRK05479 937773005149 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773005150 oligomerization interface [polypeptide binding]; other site 937773005151 NAD+ binding site [chemical binding]; other site 937773005152 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 937773005153 2-isopropylmalate synthase; Validated; Region: PRK00915 937773005154 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 937773005155 active site 937773005156 catalytic residues [active] 937773005157 metal binding site [ion binding]; metal-binding site 937773005158 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 937773005159 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 937773005160 tartrate dehydrogenase; Provisional; Region: PRK08194 937773005161 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 937773005162 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 937773005163 substrate binding site [chemical binding]; other site 937773005164 ligand binding site [chemical binding]; other site 937773005165 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 937773005166 substrate binding site [chemical binding]; other site 937773005167 threonine dehydratase; Validated; Region: PRK08639 937773005168 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 937773005169 tetramer interface [polypeptide binding]; other site 937773005170 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773005171 catalytic residue [active] 937773005172 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 937773005173 putative Ile/Val binding site [chemical binding]; other site 937773005174 H+ Antiporter protein; Region: 2A0121; TIGR00900 937773005175 hypothetical protein; Provisional; Region: PRK04351 937773005176 SprT homologues; Region: SprT; cl01182 937773005177 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 937773005178 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 937773005179 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 937773005180 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 937773005181 RNA binding site [nucleotide binding]; other site 937773005182 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 937773005183 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 937773005184 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 937773005185 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 937773005186 DNA binding residues [nucleotide binding] 937773005187 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 937773005188 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 937773005189 ATP binding site [chemical binding]; other site 937773005190 Mg2+ binding site [ion binding]; other site 937773005191 G-X-G motif; other site 937773005192 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 937773005193 anti sigma factor interaction site; other site 937773005194 regulatory phosphorylation site [posttranslational modification]; other site 937773005195 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 937773005196 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 937773005197 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 937773005198 PemK-like protein; Region: PemK; cl00995 937773005199 alanine racemase; Reviewed; Region: alr; PRK00053 937773005200 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 937773005201 active site 937773005202 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 937773005203 dimer interface [polypeptide binding]; other site 937773005204 substrate binding site [chemical binding]; other site 937773005205 catalytic residues [active] 937773005206 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 937773005207 Bacterial PH domain; Region: DUF304; cl01348 937773005208 Predicted membrane protein [Function unknown]; Region: COG3428 937773005209 Bacterial PH domain; Region: DUF304; cl01348 937773005210 Bacterial PH domain; Region: DUF304; cl01348 937773005211 Bacterial PH domain; Region: DUF304; cl01348 937773005212 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 937773005213 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 937773005214 ATP binding site [chemical binding]; other site 937773005215 Mg++ binding site [ion binding]; other site 937773005216 motif III; other site 937773005217 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 937773005218 nucleotide binding region [chemical binding]; other site 937773005219 ATP-binding site [chemical binding]; other site 937773005220 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 937773005221 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 937773005222 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 937773005223 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 937773005224 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 937773005225 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 937773005226 ATP-grasp domain; Region: ATP-grasp_4; cl03087 937773005227 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 937773005228 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 937773005229 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 937773005230 metal-binding site [ion binding] 937773005231 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 937773005232 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 937773005233 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 937773005234 metal-binding site [ion binding] 937773005235 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 937773005236 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 937773005237 putative homotetramer interface [polypeptide binding]; other site 937773005238 putative homodimer interface [polypeptide binding]; other site 937773005239 allosteric switch controlling residues; other site 937773005240 putative metal binding site [ion binding]; other site 937773005241 putative homodimer-homodimer interface [polypeptide binding]; other site 937773005242 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 937773005243 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 937773005244 putative active site [active] 937773005245 catalytic site [active] 937773005246 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 937773005247 putative active site [active] 937773005248 catalytic site [active] 937773005249 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 937773005250 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 937773005251 OxaA-like protein precursor; Provisional; Region: PRK02463 937773005252 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 937773005253 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 937773005254 thiamine phosphate binding site [chemical binding]; other site 937773005255 active site 937773005256 pyrophosphate binding site [ion binding]; other site 937773005257 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 937773005258 substrate binding site [chemical binding]; other site 937773005259 multimerization interface [polypeptide binding]; other site 937773005260 ATP binding site [chemical binding]; other site 937773005261 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 937773005262 dimer interface [polypeptide binding]; other site 937773005263 substrate binding site [chemical binding]; other site 937773005264 ATP binding site [chemical binding]; other site 937773005265 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 937773005266 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 937773005267 dimer interface [polypeptide binding]; other site 937773005268 ssDNA binding site [nucleotide binding]; other site 937773005269 tetramer (dimer of dimers) interface [polypeptide binding]; other site 937773005270 YwpF-like protein; Region: YwpF; pfam14183 937773005271 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 937773005272 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 937773005273 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 937773005274 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 937773005275 hinge; other site 937773005276 active site 937773005277 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 937773005278 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 937773005279 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 937773005280 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 937773005281 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 937773005282 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 937773005283 alpha subunit interaction interface [polypeptide binding]; other site 937773005284 Walker A motif; other site 937773005285 ATP binding site [chemical binding]; other site 937773005286 Walker B motif; other site 937773005287 inhibitor binding site; inhibition site 937773005288 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 937773005289 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 937773005290 ATP synthase; Region: ATP-synt; cl00365 937773005291 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 937773005292 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 937773005293 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 937773005294 beta subunit interaction interface [polypeptide binding]; other site 937773005295 Walker A motif; other site 937773005296 ATP binding site [chemical binding]; other site 937773005297 Walker B motif; other site 937773005298 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 937773005299 Plant ATP synthase F0; Region: YMF19; cl07975 937773005300 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 937773005301 Plant ATP synthase F0; Region: YMF19; cl07975 937773005302 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 937773005303 ATP synthase subunit C; Region: ATP-synt_C; cl00466 937773005304 ATP synthase A chain; Region: ATP-synt_A; cl00413 937773005305 ATP synthase I chain; Region: ATP_synt_I; cl09170 937773005306 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 937773005307 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 937773005308 active site 937773005309 homodimer interface [polypeptide binding]; other site 937773005310 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 937773005311 active site 937773005312 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 937773005313 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 937773005314 dimer interface [polypeptide binding]; other site 937773005315 glycine-pyridoxal phosphate binding site [chemical binding]; other site 937773005316 active site 937773005317 folate binding site [chemical binding]; other site 937773005318 Protein of unknown function (DUF436); Region: DUF436; cl01860 937773005319 Low molecular weight phosphatase family; Region: LMWPc; cd00115 937773005320 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 937773005321 active site 937773005322 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 937773005323 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 937773005324 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 937773005325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 937773005326 S-adenosylmethionine binding site [chemical binding]; other site 937773005327 peptide chain release factor 1; Validated; Region: prfA; PRK00591 937773005328 RF-1 domain; Region: RF-1; cl02875 937773005329 RF-1 domain; Region: RF-1; cl02875 937773005330 thymidine kinase; Provisional; Region: PRK04296 937773005331 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 937773005332 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 937773005333 transcription termination factor Rho; Provisional; Region: rho; PRK09376 937773005334 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 937773005335 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 937773005336 RNA binding site [nucleotide binding]; other site 937773005337 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773005338 Walker A motif; other site 937773005339 ATP binding site [chemical binding]; other site 937773005340 Walker B motif; other site 937773005341 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 937773005342 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 937773005343 NAD binding site [chemical binding]; other site 937773005344 catalytic residues [active] 937773005345 Helix-turn-helix domains; Region: HTH; cl00088 937773005346 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 937773005347 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 937773005348 hinge; other site 937773005349 active site 937773005350 hypothetical protein; Provisional; Region: PRK08185 937773005351 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 937773005352 intersubunit interface [polypeptide binding]; other site 937773005353 active site 937773005354 zinc binding site [ion binding]; other site 937773005355 Na+ binding site [ion binding]; other site 937773005356 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 937773005357 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 937773005358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773005359 putative substrate translocation pore; other site 937773005360 CTP synthetase; Validated; Region: pyrG; PRK05380 937773005361 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 937773005362 Catalytic site [active] 937773005363 active site 937773005364 UTP binding site [chemical binding]; other site 937773005365 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 937773005366 active site 937773005367 putative oxyanion hole; other site 937773005368 catalytic triad [active] 937773005369 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 937773005370 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 937773005371 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 937773005372 BCCT family transporter; Region: BCCT; cl00569 937773005373 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 937773005374 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 937773005375 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 937773005376 ATP-grasp domain; Region: ATP-grasp_4; cl03087 937773005377 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 937773005378 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 937773005379 metal binding site [ion binding]; metal-binding site 937773005380 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 937773005381 Predicted membrane protein [Function unknown]; Region: COG4270 937773005382 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 937773005383 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 937773005384 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 937773005385 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 937773005386 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 937773005387 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 937773005388 Protein of unknown function, DUF393; Region: DUF393; cl01136 937773005389 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 937773005390 EVE domain; Region: EVE; cl00728 937773005391 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 937773005392 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 937773005393 Transcriptional regulators [Transcription]; Region: FadR; COG2186 937773005394 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 937773005395 DNA-binding site [nucleotide binding]; DNA binding site 937773005396 FCD domain; Region: FCD; cl11656 937773005397 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 937773005398 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 937773005399 active site 937773005400 motif I; other site 937773005401 motif II; other site 937773005402 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 937773005403 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 937773005404 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773005405 Walker A/P-loop; other site 937773005406 ATP binding site [chemical binding]; other site 937773005407 Q-loop/lid; other site 937773005408 ABC transporter signature motif; other site 937773005409 Walker B; other site 937773005410 D-loop; other site 937773005411 H-loop/switch region; other site 937773005412 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 937773005413 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 937773005414 glutaminase active site [active] 937773005415 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 937773005416 dimer interface [polypeptide binding]; other site 937773005417 active site 937773005418 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 937773005419 dimer interface [polypeptide binding]; other site 937773005420 active site 937773005421 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 937773005422 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 937773005423 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 937773005424 active site 937773005425 P-loop; other site 937773005426 phosphorylation site [posttranslational modification] 937773005427 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 937773005428 PRD domain; Region: PRD; cl15445 937773005429 PRD domain; Region: PRD; cl15445 937773005430 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 937773005431 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 937773005432 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 937773005433 active site 937773005434 phosphorylation site [posttranslational modification] 937773005435 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 937773005436 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 937773005437 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 937773005438 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 937773005439 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 937773005440 active site 937773005441 substrate binding site [chemical binding]; other site 937773005442 metal binding site [ion binding]; metal-binding site 937773005443 YbbR-like protein; Region: YbbR; pfam07949 937773005444 YbbR-like protein; Region: YbbR; pfam07949 937773005445 TIGR00159 family protein; Region: TIGR00159 937773005446 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 937773005447 Arginase family; Region: Arginase; cl00306 937773005448 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 937773005449 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 937773005450 Walker A motif; other site 937773005451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773005452 Major Facilitator Superfamily; Region: MFS_1; pfam07690 937773005453 putative substrate translocation pore; other site 937773005454 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 937773005455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773005456 putative substrate translocation pore; other site 937773005457 Haemolysin-III related; Region: HlyIII; cl03831 937773005458 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 937773005459 active site 937773005460 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 937773005461 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 937773005462 Nucleoside recognition; Region: Gate; cl00486 937773005463 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 937773005464 ABC-ATPase subunit interface; other site 937773005465 dimer interface [polypeptide binding]; other site 937773005466 putative PBP binding regions; other site 937773005467 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 937773005468 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 937773005469 ABC-ATPase subunit interface; other site 937773005470 dimer interface [polypeptide binding]; other site 937773005471 putative PBP binding regions; other site 937773005472 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 937773005473 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 937773005474 siderophore binding site; other site 937773005475 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 937773005476 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 937773005477 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 937773005478 catalytic residue [active] 937773005479 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 937773005480 IucA / IucC family; Region: IucA_IucC; pfam04183 937773005481 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 937773005482 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773005483 putative substrate translocation pore; other site 937773005484 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 937773005485 IucA / IucC family; Region: IucA_IucC; pfam04183 937773005486 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 937773005487 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773005488 Major Facilitator Superfamily; Region: MFS_1; pfam07690 937773005489 putative substrate translocation pore; other site 937773005490 Asp23 family; Region: Asp23; cl00574 937773005491 Asp23 family; Region: Asp23; cl00574 937773005492 BCCT family transporter; Region: BCCT; cl00569 937773005493 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 937773005494 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 937773005495 putative NAD(P) binding site [chemical binding]; other site 937773005496 dimer interface [polypeptide binding]; other site 937773005497 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 937773005498 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 937773005499 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 937773005500 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 937773005501 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 937773005502 ABC transporter; Region: ABC_tran_2; pfam12848 937773005503 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 937773005504 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 937773005505 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 937773005506 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 937773005507 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 937773005508 P-loop; other site 937773005509 active site 937773005510 phosphorylation site [posttranslational modification] 937773005511 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 937773005512 active site 937773005513 methionine cluster; other site 937773005514 phosphorylation site [posttranslational modification] 937773005515 metal binding site [ion binding]; metal-binding site 937773005516 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 937773005517 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 937773005518 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 937773005519 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 937773005520 Helix-turn-helix domains; Region: HTH; cl00088 937773005521 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 937773005522 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 937773005523 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 937773005524 ATP binding site [chemical binding]; other site 937773005525 putative Mg++ binding site [ion binding]; other site 937773005526 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 937773005527 nucleotide binding region [chemical binding]; other site 937773005528 ATP-binding site [chemical binding]; other site 937773005529 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 937773005530 putative active site [active] 937773005531 catalytic site [active] 937773005532 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 937773005533 beta-lactamase TEM; Provisional; Region: PRK15442 937773005534 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 937773005535 BlaR1 peptidase M56; Region: Peptidase_M56; cl15829 937773005536 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 937773005537 Helix-turn-helix domains; Region: HTH; cl00088 937773005538 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 937773005539 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 937773005540 catalytic residues [active] 937773005541 catalytic nucleophile [active] 937773005542 Presynaptic Site I dimer interface [polypeptide binding]; other site 937773005543 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 937773005544 Synaptic Flat tetramer interface [polypeptide binding]; other site 937773005545 Synaptic Site I dimer interface [polypeptide binding]; other site 937773005546 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 937773005547 DNA-binding interface [nucleotide binding]; DNA binding site 937773005548 Helix-turn-helix domains; Region: HTH; cl00088 937773005549 Integrase core domain; Region: rve; cl01316 937773005550 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 937773005551 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 937773005552 RES domain; Region: RES; cl02411 937773005553 Isochorismatase family; Region: Isochorismatase; pfam00857 937773005554 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 937773005555 catalytic triad [active] 937773005556 conserved cis-peptide bond; other site 937773005557 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 937773005558 Divergent AAA domain; Region: AAA_4; pfam04326 937773005559 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 937773005560 Helix-turn-helix domains; Region: HTH; cl00088 937773005561 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 937773005562 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 937773005563 23S rRNA interface [nucleotide binding]; other site 937773005564 L3 interface [polypeptide binding]; other site 937773005565 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 937773005566 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 937773005567 dimerization interface 3.5A [polypeptide binding]; other site 937773005568 active site 937773005569 Cobalt transport protein; Region: CbiQ; cl00463 937773005570 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646 937773005571 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 937773005572 Walker A/P-loop; other site 937773005573 ATP binding site [chemical binding]; other site 937773005574 Q-loop/lid; other site 937773005575 ABC transporter signature motif; other site 937773005576 Walker B; other site 937773005577 D-loop; other site 937773005578 H-loop/switch region; other site 937773005579 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648 937773005580 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 937773005581 Walker A/P-loop; other site 937773005582 ATP binding site [chemical binding]; other site 937773005583 Q-loop/lid; other site 937773005584 ABC transporter signature motif; other site 937773005585 Walker B; other site 937773005586 D-loop; other site 937773005587 H-loop/switch region; other site 937773005588 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 937773005589 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 937773005590 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 937773005591 alphaNTD homodimer interface [polypeptide binding]; other site 937773005592 alphaNTD - beta interaction site [polypeptide binding]; other site 937773005593 alphaNTD - beta' interaction site [polypeptide binding]; other site 937773005594 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 937773005595 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 937773005596 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 937773005597 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 937773005598 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 937773005599 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 937773005600 rRNA binding site [nucleotide binding]; other site 937773005601 predicted 30S ribosome binding site; other site 937773005602 adenylate kinase; Reviewed; Region: adk; PRK00279 937773005603 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 937773005604 AMP-binding site [chemical binding]; other site 937773005605 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 937773005606 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 937773005607 SecY translocase; Region: SecY; pfam00344 937773005608 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 937773005609 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 937773005610 23S rRNA binding site [nucleotide binding]; other site 937773005611 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 937773005612 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 937773005613 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 937773005614 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 937773005615 5S rRNA interface [nucleotide binding]; other site 937773005616 L27 interface [polypeptide binding]; other site 937773005617 23S rRNA interface [nucleotide binding]; other site 937773005618 L5 interface [polypeptide binding]; other site 937773005619 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 937773005620 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 937773005621 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 937773005622 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 937773005623 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 937773005624 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 937773005625 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 937773005626 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 937773005627 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 937773005628 KOW motif; Region: KOW; cl00354 937773005629 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 937773005630 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 937773005631 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 937773005632 23S rRNA interface [nucleotide binding]; other site 937773005633 putative translocon interaction site; other site 937773005634 signal recognition particle (SRP54) interaction site; other site 937773005635 L23 interface [polypeptide binding]; other site 937773005636 trigger factor interaction site; other site 937773005637 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 937773005638 23S rRNA interface [nucleotide binding]; other site 937773005639 5S rRNA interface [nucleotide binding]; other site 937773005640 putative antibiotic binding site [chemical binding]; other site 937773005641 L25 interface [polypeptide binding]; other site 937773005642 L27 interface [polypeptide binding]; other site 937773005643 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 937773005644 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 937773005645 G-X-X-G motif; other site 937773005646 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 937773005647 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 937773005648 putative translocon binding site; other site 937773005649 protein-rRNA interface [nucleotide binding]; other site 937773005650 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 937773005651 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 937773005652 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 937773005653 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 937773005654 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 937773005655 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 937773005656 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 937773005657 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 937773005658 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 937773005659 DNA topoisomerase III; Provisional; Region: PRK07726 937773005660 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 937773005661 active site 937773005662 putative interdomain interaction site [polypeptide binding]; other site 937773005663 putative metal-binding site [ion binding]; other site 937773005664 putative nucleotide binding site [chemical binding]; other site 937773005665 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 937773005666 domain I; other site 937773005667 DNA binding groove [nucleotide binding] 937773005668 phosphate binding site [ion binding]; other site 937773005669 domain II; other site 937773005670 domain III; other site 937773005671 nucleotide binding site [chemical binding]; other site 937773005672 catalytic site [active] 937773005673 domain IV; other site 937773005674 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 937773005675 Membrane transport protein; Region: Mem_trans; cl09117 937773005676 transaminase; Reviewed; Region: PRK08068 937773005677 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 937773005678 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773005679 homodimer interface [polypeptide binding]; other site 937773005680 catalytic residue [active] 937773005681 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 937773005682 Protein export membrane protein; Region: SecD_SecF; cl14618 937773005683 Protein export membrane protein; Region: SecD_SecF; cl14618 937773005684 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 937773005685 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 937773005686 Helix-turn-helix domains; Region: HTH; cl00088 937773005687 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 937773005688 generic binding surface II; other site 937773005689 generic binding surface I; other site 937773005690 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 937773005691 putative catalytic site [active] 937773005692 putative metal binding site [ion binding]; other site 937773005693 putative phosphate binding site [ion binding]; other site 937773005694 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 937773005695 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 937773005696 FeS/SAM binding site; other site 937773005697 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 937773005698 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 937773005699 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 937773005700 GTP binding site; other site 937773005701 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 937773005702 MoaE interaction surface [polypeptide binding]; other site 937773005703 MoeB interaction surface [polypeptide binding]; other site 937773005704 thiocarboxylated glycine; other site 937773005705 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 937773005706 MoaE homodimer interface [polypeptide binding]; other site 937773005707 MoaD interaction [polypeptide binding]; other site 937773005708 active site residues [active] 937773005709 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773005710 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 937773005711 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 937773005712 dimer interface [polypeptide binding]; other site 937773005713 putative functional site; other site 937773005714 putative MPT binding site; other site 937773005715 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 937773005716 trimer interface [polypeptide binding]; other site 937773005717 dimer interface [polypeptide binding]; other site 937773005718 putative active site [active] 937773005719 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 937773005720 MPT binding site; other site 937773005721 trimer interface [polypeptide binding]; other site 937773005722 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 937773005723 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 937773005724 ATP binding site [chemical binding]; other site 937773005725 substrate interface [chemical binding]; other site 937773005726 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773005727 thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277 937773005728 Walker A/P-loop; other site 937773005729 ATP binding site [chemical binding]; other site 937773005730 Q-loop/lid; other site 937773005731 ABC transporter signature motif; other site 937773005732 Walker B; other site 937773005733 D-loop; other site 937773005734 H-loop/switch region; other site 937773005735 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 937773005736 dimer interface [polypeptide binding]; other site 937773005737 conserved gate region; other site 937773005738 putative PBP binding loops; other site 937773005739 ABC-ATPase subunit interface; other site 937773005740 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 937773005741 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 937773005742 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 937773005743 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 937773005744 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 937773005745 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 937773005746 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 937773005747 NAD binding site [chemical binding]; other site 937773005748 homodimer interface [polypeptide binding]; other site 937773005749 active site 937773005750 substrate binding site [chemical binding]; other site 937773005751 galactokinase; Provisional; Region: PRK05322 937773005752 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 937773005753 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 937773005754 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 937773005755 Transcriptional regulators [Transcription]; Region: PurR; COG1609 937773005756 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 937773005757 DNA binding site [nucleotide binding] 937773005758 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 937773005759 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 937773005760 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 937773005761 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 937773005762 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 937773005763 Transcriptional regulators [Transcription]; Region: FadR; COG2186 937773005764 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 937773005765 DNA-binding site [nucleotide binding]; DNA binding site 937773005766 FCD domain; Region: FCD; cl11656 937773005767 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 937773005768 N-acetylneuraminate lyase; Region: nanA; TIGR00683 937773005769 inhibitor site; inhibition site 937773005770 active site 937773005771 dimer interface [polypeptide binding]; other site 937773005772 catalytic residue [active] 937773005773 Sodium:solute symporter family; Region: SSF; cl00456 937773005774 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 937773005775 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 937773005776 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 937773005777 intersubunit interface [polypeptide binding]; other site 937773005778 Protein of unknown function (DUF454); Region: DUF454; cl01063 937773005779 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 937773005780 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 937773005781 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 937773005782 Helix-turn-helix domains; Region: HTH; cl00088 937773005783 DoxX; Region: DoxX; cl00976 937773005784 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 937773005785 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 937773005786 NlpC/P60 family; Region: NLPC_P60; cl11438 937773005787 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 937773005788 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773005789 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 937773005790 NlpC/P60 family; Region: NLPC_P60; cl11438 937773005791 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 937773005792 glyoxylate reductase; Reviewed; Region: PRK13243 937773005793 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773005794 hypothetical protein; Provisional; Region: PRK06753 937773005795 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773005796 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 937773005797 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 937773005798 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 937773005799 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 937773005800 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 937773005801 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 937773005802 4Fe-4S binding domain; Region: Fer4; cl02805 937773005803 4Fe-4S binding domain; Region: Fer4; cl02805 937773005804 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 937773005805 [4Fe-4S] binding site [ion binding]; other site 937773005806 molybdopterin cofactor binding site; other site 937773005807 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 937773005808 molybdopterin cofactor binding site; other site 937773005809 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 937773005810 putative substrate binding pocket [chemical binding]; other site 937773005811 AC domain interface; other site 937773005812 catalytic triad [active] 937773005813 AB domain interface; other site 937773005814 interchain disulfide; other site 937773005815 Protein of unknown function (DUF979); Region: DUF979; cl01572 937773005816 Protein of unknown function (DUF969); Region: DUF969; cl01573 937773005817 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 937773005818 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 937773005819 active site 937773005820 Predicted transcriptional regulator [Transcription]; Region: COG2378 937773005821 Helix-turn-helix domains; Region: HTH; cl00088 937773005822 CAAX protease self-immunity; Region: Abi; cl00558 937773005823 putative transport protein YifK; Provisional; Region: PRK10746 937773005824 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 937773005825 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 937773005826 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 937773005827 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 937773005828 motif II; other site 937773005829 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 937773005830 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 937773005831 Zn binding site [ion binding]; other site 937773005832 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 937773005833 active site 937773005834 metal binding site [ion binding]; metal-binding site 937773005835 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 937773005836 Membrane transport protein; Region: Mem_trans; cl09117 937773005837 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 937773005838 putative hydrophobic ligand binding site [chemical binding]; other site 937773005839 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 937773005840 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 937773005841 amidohydrolase; Region: amidohydrolases; TIGR01891 937773005842 metal binding site [ion binding]; metal-binding site 937773005843 dimer interface [polypeptide binding]; other site 937773005844 Sulfate transporter family; Region: Sulfate_transp; cl15842 937773005845 Sulfate transporter family; Region: Sulfate_transp; cl15842 937773005846 imidazolonepropionase; Validated; Region: PRK09356 937773005847 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 937773005848 active site 937773005849 urocanate hydratase; Provisional; Region: PRK05414 937773005850 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 937773005851 Nucleoside recognition; Region: Gate; cl00486 937773005852 Transcriptional regulator [Transcription]; Region: LysR; COG0583 937773005853 Helix-turn-helix domains; Region: HTH; cl00088 937773005854 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 937773005855 dimerization interface [polypeptide binding]; other site 937773005856 CAAX protease self-immunity; Region: Abi; cl00558 937773005857 Arginase family; Region: Arginase; cl00306 937773005858 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 937773005859 tetramer (dimer of dimers) interface [polypeptide binding]; other site 937773005860 active site 937773005861 dimer interface [polypeptide binding]; other site 937773005862 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 937773005863 MOSC domain; Region: MOSC; pfam03473 937773005864 3-alpha domain; Region: 3-alpha; pfam03475 937773005865 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 937773005866 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 937773005867 active site 937773005868 catalytic residues [active] 937773005869 Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 937773005870 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 937773005871 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 937773005872 This subfamily is involved in drug resistance, nodulation, lipid transport, and bacteriocin and lantibiotic immunity. In eubacteria and archaea, the typical organization consists of one ABC and one or two IMs. Eukaryote systems of the ABCA subfamily...; Region: ABC_putative_ATPase; cd03269 937773005873 Walker A/P-loop; other site 937773005874 ATP binding site [chemical binding]; other site 937773005875 Q-loop/lid; other site 937773005876 ABC transporter signature motif; other site 937773005877 Walker B; other site 937773005878 D-loop; other site 937773005879 H-loop/switch region; other site 937773005880 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 937773005881 Protein of unknown function (DUF805); Region: DUF805; cl01224 937773005882 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 937773005883 active site 937773005884 DNA binding site [nucleotide binding] 937773005885 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 937773005886 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 937773005887 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 937773005888 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 937773005889 Helix-turn-helix domains; Region: HTH; cl00088 937773005890 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 937773005891 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 937773005892 Cupin domain; Region: Cupin_2; cl09118 937773005893 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 937773005894 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 937773005895 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 937773005896 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 937773005897 Transposase, Mutator family; Region: Transposase_mut; pfam00872 937773005898 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 937773005899 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39B; cd02418 937773005900 putative active site [active] 937773005901 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 937773005902 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773005903 Walker A/P-loop; other site 937773005904 ATP binding site [chemical binding]; other site 937773005905 Q-loop/lid; other site 937773005906 ABC transporter signature motif; other site 937773005907 Walker B; other site 937773005908 D-loop; other site 937773005909 H-loop/switch region; other site 937773005910 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 937773005911 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773005912 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 937773005913 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 937773005914 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 937773005915 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 937773005916 homotetramer interface [polypeptide binding]; other site 937773005917 FMN binding site [chemical binding]; other site 937773005918 homodimer contacts [polypeptide binding]; other site 937773005919 putative active site [active] 937773005920 putative substrate binding site [chemical binding]; other site 937773005921 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 937773005922 active site 937773005923 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 937773005924 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 937773005925 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 937773005926 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 937773005927 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 937773005928 catalytic residues [active] 937773005929 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 937773005930 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 937773005931 Helix-turn-helix domains; Region: HTH; cl00088 937773005932 Predicted membrane protein [Function unknown]; Region: COG4640 937773005933 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 937773005934 Helix-turn-helix domains; Region: HTH; cl00088 937773005935 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 937773005936 putative active site [active] 937773005937 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 937773005938 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 937773005939 Walker A/P-loop; other site 937773005940 ATP binding site [chemical binding]; other site 937773005941 Q-loop/lid; other site 937773005942 ABC transporter signature motif; other site 937773005943 Walker B; other site 937773005944 D-loop; other site 937773005945 H-loop/switch region; other site 937773005946 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 937773005947 FtsX-like permease family; Region: FtsX; cl15850 937773005948 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 937773005949 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 937773005950 active site 937773005951 phosphorylation site [posttranslational modification] 937773005952 intermolecular recognition site; other site 937773005953 dimerization interface [polypeptide binding]; other site 937773005954 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 937773005955 DNA binding site [nucleotide binding] 937773005956 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 937773005957 dimerization interface [polypeptide binding]; other site 937773005958 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 937773005959 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 937773005960 ATP binding site [chemical binding]; other site 937773005961 Mg2+ binding site [ion binding]; other site 937773005962 G-X-G motif; other site 937773005963 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773005964 Predicted dehydrogenase [General function prediction only]; Region: COG0579 937773005965 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 937773005966 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 937773005967 putative ADP-binding pocket [chemical binding]; other site 937773005968 glycolate transporter; Provisional; Region: PRK09695 937773005969 L-lactate permease; Region: Lactate_perm; cl00701 937773005970 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 937773005971 folate binding site [chemical binding]; other site 937773005972 NADP+ binding site [chemical binding]; other site 937773005973 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 937773005974 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 937773005975 Coenzyme A binding pocket [chemical binding]; other site 937773005976 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773005977 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 937773005978 NAD(P) binding site [chemical binding]; other site 937773005979 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773005980 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 937773005981 putative substrate translocation pore; other site 937773005982 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 937773005983 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773005984 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 937773005985 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 937773005986 Coenzyme A binding pocket [chemical binding]; other site 937773005987 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 937773005988 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 937773005989 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 937773005990 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 937773005991 PhoU domain; Region: PhoU; pfam01895 937773005992 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 937773005993 Helix-turn-helix domains; Region: HTH; cl00088 937773005994 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 937773005995 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 937773005996 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 937773005997 active site turn [active] 937773005998 phosphorylation site [posttranslational modification] 937773005999 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 937773006000 Helix-turn-helix domain; Region: HTH_18; pfam12833 937773006001 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 937773006002 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 937773006003 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773006004 putative substrate translocation pore; other site 937773006005 EamA-like transporter family; Region: EamA; cl01037 937773006006 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 937773006007 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 937773006008 oligomer interface [polypeptide binding]; other site 937773006009 active site 937773006010 metal binding site [ion binding]; metal-binding site 937773006011 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773006012 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 937773006013 NAD(P) binding site [chemical binding]; other site 937773006014 LDH/MDH dimer interface [polypeptide binding]; other site 937773006015 substrate binding site [chemical binding]; other site 937773006016 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 937773006017 Arginine degradation protein (predicted deacylase) [Amino acid transport and metabolism]; Region: RocB; COG4187 937773006018 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 937773006019 putative metal binding site [ion binding]; other site 937773006020 putative dimer interface [polypeptide binding]; other site 937773006021 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 937773006022 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773006023 putative substrate translocation pore; other site 937773006024 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 937773006025 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 937773006026 active site 937773006027 phosphorylation site [posttranslational modification] 937773006028 intermolecular recognition site; other site 937773006029 dimerization interface [polypeptide binding]; other site 937773006030 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 937773006031 DNA binding residues [nucleotide binding] 937773006032 dimerization interface [polypeptide binding]; other site 937773006033 Histidine kinase; Region: HisKA_3; pfam07730 937773006034 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 937773006035 ATP binding site [chemical binding]; other site 937773006036 Mg2+ binding site [ion binding]; other site 937773006037 G-X-G motif; other site 937773006038 GAF domain; Region: GAF; cl15785 937773006039 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 937773006040 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 937773006041 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 937773006042 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 937773006043 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 937773006044 [4Fe-4S] binding site [ion binding]; other site 937773006045 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 937773006046 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 937773006047 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 937773006048 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 937773006049 molybdopterin cofactor binding site; other site 937773006050 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 937773006051 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 937773006052 active site 937773006053 metal binding site [ion binding]; metal-binding site 937773006054 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 937773006055 Gram positive anchor; Region: Gram_pos_anchor; cl15427 937773006056 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 937773006057 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 937773006058 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 937773006059 [2Fe-2S] cluster binding site [ion binding]; other site 937773006060 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 937773006061 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 937773006062 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 937773006063 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 937773006064 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 937773006065 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773006066 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 937773006067 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 937773006068 putative active site [active] 937773006069 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 937773006070 active site 937773006071 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 937773006072 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 937773006073 Coenzyme A binding pocket [chemical binding]; other site 937773006074 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 937773006075 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 937773006076 transmembrane helices; other site 937773006077 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 937773006078 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 937773006079 Replication initiation factor; Region: Rep_trans; pfam02486 937773006080 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 937773006081 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 937773006082 NAD(P) binding site [chemical binding]; other site 937773006083 catalytic residues [active] 937773006084 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 937773006085 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 937773006086 active site 937773006087 metal binding site [ion binding]; metal-binding site 937773006088 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 937773006089 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 937773006090 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 937773006091 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 937773006092 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 937773006093 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 937773006094 dimer interface [polypeptide binding]; other site 937773006095 conserved gate region; other site 937773006096 putative PBP binding loops; other site 937773006097 ABC-ATPase subunit interface; other site 937773006098 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 937773006099 NADH(P)-binding; Region: NAD_binding_10; pfam13460 937773006100 NAD(P) binding site [chemical binding]; other site 937773006101 putative active site [active] 937773006102 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 937773006103 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 937773006104 FeS/SAM binding site; other site 937773006105 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 937773006106 Pyruvate formate lyase 1; Region: PFL1; cd01678 937773006107 coenzyme A binding site [chemical binding]; other site 937773006108 active site 937773006109 catalytic residues [active] 937773006110 glycine loop; other site 937773006111 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 937773006112 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 937773006113 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 937773006114 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 937773006115 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 937773006116 NAD binding site [chemical binding]; other site 937773006117 Phe binding site; other site 937773006118 cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276 937773006119 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 937773006120 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 937773006121 Glycerate kinase family; Region: Gly_kinase; cl00841 937773006122 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 937773006123 active site 937773006124 catalytic site [active] 937773006125 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773006126 D-galactonate transporter; Region: 2A0114; TIGR00893 937773006127 putative substrate translocation pore; other site 937773006128 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773006129 Major Facilitator Superfamily; Region: MFS_1; pfam07690 937773006130 putative substrate translocation pore; other site 937773006131 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 937773006132 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 937773006133 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 937773006134 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 937773006135 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 937773006136 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 937773006137 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 937773006138 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 937773006139 DNA binding residues [nucleotide binding] 937773006140 dimer interface [polypeptide binding]; other site 937773006141 DNA binding domain of tn916 integrase; Region: Integrase_DNA; pfam02920 937773006142 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 937773006143 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 937773006144 Int/Topo IB signature motif; other site 937773006145 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 937773006146 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 937773006147 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 937773006148 DNA binding residues [nucleotide binding] 937773006149 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 937773006150 non-specific DNA binding site [nucleotide binding]; other site 937773006151 salt bridge; other site 937773006152 sequence-specific DNA binding site [nucleotide binding]; other site 937773006153 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 937773006154 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 937773006155 G1 box; other site 937773006156 putative GEF interaction site [polypeptide binding]; other site 937773006157 GTP/Mg2+ binding site [chemical binding]; other site 937773006158 Switch I region; other site 937773006159 G2 box; other site 937773006160 G3 box; other site 937773006161 Switch II region; other site 937773006162 G4 box; other site 937773006163 G5 box; other site 937773006164 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 937773006165 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 937773006166 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 937773006167 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 937773006168 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 937773006169 NlpC/P60 family; Region: NLPC_P60; cl11438 937773006170 Haemolysin-III related; Region: HlyIII; cl03831 937773006171 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 937773006172 AAA-like domain; Region: AAA_10; pfam12846 937773006173 TcpE family; Region: TcpE; pfam12648 937773006174 Antirestriction protein (ArdA); Region: ArdA; cl01953 937773006175 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 937773006176 Putative phage replication protein RstA [DNA replication, recombination, and repair]; Region: COG2946 937773006177 non-specific DNA binding site [nucleotide binding]; other site 937773006178 salt bridge; other site 937773006179 sequence-specific DNA binding site [nucleotide binding]; other site 937773006180 Replication initiation factor; Region: Rep_trans; pfam02486 937773006181 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773006182 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 937773006183 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 937773006184 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 937773006185 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 937773006186 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 937773006187 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 937773006188 Walker A/P-loop; other site 937773006189 ATP binding site [chemical binding]; other site 937773006190 Q-loop/lid; other site 937773006191 ABC transporter signature motif; other site 937773006192 Walker B; other site 937773006193 D-loop; other site 937773006194 H-loop/switch region; other site 937773006195 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 937773006196 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 937773006197 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773006198 Walker A/P-loop; other site 937773006199 ATP binding site [chemical binding]; other site 937773006200 Q-loop/lid; other site 937773006201 ABC transporter signature motif; other site 937773006202 Walker B; other site 937773006203 D-loop; other site 937773006204 H-loop/switch region; other site 937773006205 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 937773006206 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 937773006207 Cysteine-rich domain; Region: CCG; pfam02754 937773006208 Cysteine-rich domain; Region: CCG; pfam02754 937773006209 FAD binding domain; Region: FAD_binding_4; pfam01565 937773006210 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 937773006211 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 937773006212 active site 937773006213 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 937773006214 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 937773006215 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 937773006216 motif II; other site 937773006217 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 937773006218 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 937773006219 substrate binding site [chemical binding]; other site 937773006220 active site 937773006221 catalytic residues [active] 937773006222 heterodimer interface [polypeptide binding]; other site 937773006223 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 937773006224 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 937773006225 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773006226 catalytic residue [active] 937773006227 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 937773006228 active site 937773006229 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 937773006230 active site 937773006231 ribulose/triose binding site [chemical binding]; other site 937773006232 phosphate binding site [ion binding]; other site 937773006233 substrate (anthranilate) binding pocket [chemical binding]; other site 937773006234 product (indole) binding pocket [chemical binding]; other site 937773006235 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 937773006236 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 937773006237 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 937773006238 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 937773006239 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 937773006240 glutamine binding [chemical binding]; other site 937773006241 catalytic triad [active] 937773006242 anthranilate synthase component I; Provisional; Region: PRK13567 937773006243 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 937773006244 chorismate binding enzyme; Region: Chorismate_bind; cl10555 937773006245 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 937773006246 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 937773006247 dimer interface [polypeptide binding]; other site 937773006248 PYR/PP interface [polypeptide binding]; other site 937773006249 TPP binding site [chemical binding]; other site 937773006250 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 937773006251 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 937773006252 TPP-binding site [chemical binding]; other site 937773006253 dimer interface [polypeptide binding]; other site 937773006254 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 937773006255 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 937773006256 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 937773006257 Helix-turn-helix domains; Region: HTH; cl00088 937773006258 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 937773006259 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773006260 oxidoreductase; Provisional; Region: PRK07985 937773006261 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773006262 NAD(P) binding site [chemical binding]; other site 937773006263 active site 937773006264 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 937773006265 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 937773006266 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 937773006267 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 937773006268 active site 937773006269 Zn binding site [ion binding]; other site 937773006270 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 937773006271 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 937773006272 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 937773006273 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773006274 active site 937773006275 cytoskeletal protein RodZ; Provisional; Region: PRK10856 937773006276 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 937773006277 Peptidase family M23; Region: Peptidase_M23; pfam01551 937773006278 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 937773006279 synthetase active site [active] 937773006280 NTP binding site [chemical binding]; other site 937773006281 metal binding site [ion binding]; metal-binding site 937773006282 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 937773006283 dimer interface [polypeptide binding]; other site 937773006284 FMN binding site [chemical binding]; other site 937773006285 Helix-turn-helix domains; Region: HTH; cl00088 937773006286 LrgB-like family; Region: LrgB; cl00596 937773006287 LrgA family; Region: LrgA; cl00608 937773006288 Transcriptional regulator [Transcription]; Region: LysR; COG0583 937773006289 Helix-turn-helix domains; Region: HTH; cl00088 937773006290 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 937773006291 putative dimerization interface [polypeptide binding]; other site 937773006292 ATP-grasp domain; Region: ATP-grasp_4; cl03087 937773006293 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 937773006294 ATP-grasp domain; Region: ATP-grasp_4; cl03087 937773006295 hypothetical protein; Provisional; Region: PRK07206 937773006296 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 937773006297 Ligand Binding Site [chemical binding]; other site 937773006298 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 937773006299 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773006300 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 937773006301 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 937773006302 trimer interface [polypeptide binding]; other site 937773006303 active site 937773006304 urease subunit alpha; Reviewed; Region: ureC; PRK13207 937773006305 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 937773006306 subunit interactions [polypeptide binding]; other site 937773006307 active site 937773006308 flap region; other site 937773006309 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 937773006310 gamma-beta subunit interface [polypeptide binding]; other site 937773006311 alpha-beta subunit interface [polypeptide binding]; other site 937773006312 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 937773006313 alpha-gamma subunit interface [polypeptide binding]; other site 937773006314 beta-gamma subunit interface [polypeptide binding]; other site 937773006315 Urea transporter; Region: UT; cl01829 937773006316 Urea transporter; Region: UT; cl01829 937773006317 Cation efflux family; Region: Cation_efflux; cl00316 937773006318 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 937773006319 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 937773006320 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 937773006321 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 937773006322 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 937773006323 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 937773006324 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 937773006325 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 937773006326 FtsX-like permease family; Region: FtsX; cl15850 937773006327 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 937773006328 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 937773006329 Walker A/P-loop; other site 937773006330 ATP binding site [chemical binding]; other site 937773006331 Q-loop/lid; other site 937773006332 ABC transporter signature motif; other site 937773006333 Walker B; other site 937773006334 D-loop; other site 937773006335 H-loop/switch region; other site 937773006336 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 937773006337 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 937773006338 Predicted membrane protein [General function prediction only]; Region: COG4194 937773006339 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 937773006340 Phosphotransferase enzyme family; Region: APH; pfam01636 937773006341 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 937773006342 active site 937773006343 ATP binding site [chemical binding]; other site 937773006344 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 937773006345 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 937773006346 dimer interface [polypeptide binding]; other site 937773006347 FMN binding site [chemical binding]; other site 937773006348 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 937773006349 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 937773006350 active site 937773006351 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 937773006352 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 937773006353 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 937773006354 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 937773006355 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 937773006356 active site 937773006357 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 937773006358 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 937773006359 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 937773006360 Walker A/P-loop; other site 937773006361 ATP binding site [chemical binding]; other site 937773006362 Q-loop/lid; other site 937773006363 ABC transporter signature motif; other site 937773006364 Walker B; other site 937773006365 D-loop; other site 937773006366 H-loop/switch region; other site 937773006367 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 937773006368 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 937773006369 Walker A/P-loop; other site 937773006370 ATP binding site [chemical binding]; other site 937773006371 Q-loop/lid; other site 937773006372 ABC transporter signature motif; other site 937773006373 Walker B; other site 937773006374 D-loop; other site 937773006375 H-loop/switch region; other site 937773006376 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 937773006377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 937773006378 dimer interface [polypeptide binding]; other site 937773006379 conserved gate region; other site 937773006380 putative PBP binding loops; other site 937773006381 ABC-ATPase subunit interface; other site 937773006382 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 937773006383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 937773006384 dimer interface [polypeptide binding]; other site 937773006385 conserved gate region; other site 937773006386 putative PBP binding loops; other site 937773006387 ABC-ATPase subunit interface; other site 937773006388 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 937773006389 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 937773006390 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 937773006391 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 937773006392 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 937773006393 S-adenosylmethionine binding site [chemical binding]; other site 937773006394 Predicted membrane protein [Function unknown]; Region: COG1511 937773006395 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 937773006396 ABC-2 type transporter; Region: ABC2_membrane; cl11417 937773006397 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 937773006398 NlpC/P60 family; Region: NLPC_P60; cl11438 937773006399 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 937773006400 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 937773006401 P-loop; other site 937773006402 active site 937773006403 phosphorylation site [posttranslational modification] 937773006404 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 937773006405 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 937773006406 active site 937773006407 phosphorylation site [posttranslational modification] 937773006408 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 937773006409 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 937773006410 DNA binding residues [nucleotide binding] 937773006411 dimer interface [polypeptide binding]; other site 937773006412 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 937773006413 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 937773006414 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 937773006415 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 937773006416 tetramerization interface [polypeptide binding]; other site 937773006417 NAD(P) binding site [chemical binding]; other site 937773006418 catalytic residues [active] 937773006419 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 937773006420 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 937773006421 PhnA protein; Region: PhnA; pfam03831 937773006422 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 937773006423 DAK2 domain; Region: Dak2; cl03685 937773006424 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 937773006425 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 937773006426 LrgB-like family; Region: LrgB; cl00596 937773006427 LrgA family; Region: LrgA; cl00608 937773006428 two-component response regulator; Provisional; Region: PRK14084 937773006429 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 937773006430 active site 937773006431 phosphorylation site [posttranslational modification] 937773006432 intermolecular recognition site; other site 937773006433 dimerization interface [polypeptide binding]; other site 937773006434 LytTr DNA-binding domain; Region: LytTR; cl04498 937773006435 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 937773006436 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 937773006437 GAF domain; Region: GAF; cl15785 937773006438 Histidine kinase; Region: His_kinase; pfam06580 937773006439 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 937773006440 ATP binding site [chemical binding]; other site 937773006441 Mg2+ binding site [ion binding]; other site 937773006442 G-X-G motif; other site 937773006443 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 937773006444 Rib/alpha-like repeat; Region: Rib; cl07159 937773006445 Sulfatase; Region: Sulfatase; cl10460 937773006446 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 937773006447 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 937773006448 intersubunit interface [polypeptide binding]; other site 937773006449 active site 937773006450 catalytic residue [active] 937773006451 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 937773006452 ATP phosphoribosyltransferase; Region: HisG; cl15266 937773006453 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 937773006454 histidinol dehydrogenase; Region: hisD; TIGR00069 937773006455 NAD binding site [chemical binding]; other site 937773006456 dimerization interface [polypeptide binding]; other site 937773006457 product binding site; other site 937773006458 substrate binding site [chemical binding]; other site 937773006459 zinc binding site [ion binding]; other site 937773006460 catalytic residues [active] 937773006461 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 937773006462 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 937773006463 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773006464 homodimer interface [polypeptide binding]; other site 937773006465 catalytic residue [active] 937773006466 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 937773006467 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 937773006468 putative active site pocket [active] 937773006469 4-fold oligomerization interface [polypeptide binding]; other site 937773006470 metal binding residues [ion binding]; metal-binding site 937773006471 3-fold/trimer interface [polypeptide binding]; other site 937773006472 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 937773006473 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 937773006474 putative active site [active] 937773006475 oxyanion strand; other site 937773006476 catalytic triad [active] 937773006477 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 937773006478 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 937773006479 catalytic residues [active] 937773006480 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 937773006481 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 937773006482 substrate binding site [chemical binding]; other site 937773006483 glutamase interaction surface [polypeptide binding]; other site 937773006484 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 937773006485 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 937773006486 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 937773006487 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 937773006488 EamA-like transporter family; Region: EamA; cl01037 937773006489 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 937773006490 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 937773006491 ornithine carbamoyltransferase; Validated; Region: PRK02102 937773006492 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 937773006493 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773006494 choline dehydrogenase; Validated; Region: PRK02106 937773006495 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 937773006496 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 937773006497 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 937773006498 tetramerization interface [polypeptide binding]; other site 937773006499 NAD(P) binding site [chemical binding]; other site 937773006500 catalytic residues [active] 937773006501 Predicted transcriptional regulators [Transcription]; Region: COG1510 937773006502 BCCT family transporter; Region: BCCT; cl00569 937773006503 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 937773006504 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 937773006505 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 937773006506 non-specific DNA binding site [nucleotide binding]; other site 937773006507 salt bridge; other site 937773006508 sequence-specific DNA binding site [nucleotide binding]; other site 937773006509 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 937773006510 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 937773006511 cofactor binding site; other site 937773006512 DNA binding site [nucleotide binding] 937773006513 substrate interaction site [chemical binding]; other site 937773006514 EcoRII C terminal; Region: EcoRII-C; pfam09019 937773006515 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 937773006516 dimer interface [polypeptide binding]; other site 937773006517 Alkaline phosphatase homologues; Region: alkPPc; smart00098 937773006518 active site 937773006519 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 937773006520 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 937773006521 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 937773006522 Catalytic site [active] 937773006523 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 937773006524 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 937773006525 non-specific DNA binding site [nucleotide binding]; other site 937773006526 salt bridge; other site 937773006527 sequence-specific DNA binding site [nucleotide binding]; other site 937773006528 Cupin domain; Region: Cupin_2; cl09118 937773006529 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 937773006530 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773006531 putative substrate translocation pore; other site 937773006532 High-affinity nickel-transport protein; Region: NicO; cl00964 937773006533 ThiC-associated domain; Region: ThiC-associated; pfam13667 937773006534 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 937773006535 ThiC family; Region: ThiC; cl08031 937773006536 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 937773006537 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 937773006538 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 937773006539 putative active site [active] 937773006540 catalytic site [active] 937773006541 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 937773006542 putative active site [active] 937773006543 catalytic site [active] 937773006544 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 937773006545 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 937773006546 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 937773006547 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 937773006548 active site 937773006549 dimerization interface [polypeptide binding]; other site 937773006550 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 937773006551 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 937773006552 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 937773006553 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 937773006554 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 937773006555 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 937773006556 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 937773006557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773006558 Major Facilitator Superfamily; Region: MFS_1; pfam07690 937773006559 putative substrate translocation pore; other site 937773006560 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 937773006561 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 937773006562 active site 937773006563 tetramer interface; other site 937773006564 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 937773006565 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 937773006566 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 937773006567 Histidine kinase; Region: His_kinase; pfam06580 937773006568 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 937773006569 ATP binding site [chemical binding]; other site 937773006570 Mg2+ binding site [ion binding]; other site 937773006571 G-X-G motif; other site 937773006572 Response regulator receiver domain; Region: Response_reg; pfam00072 937773006573 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 937773006574 active site 937773006575 phosphorylation site [posttranslational modification] 937773006576 intermolecular recognition site; other site 937773006577 dimerization interface [polypeptide binding]; other site 937773006578 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 937773006579 Helix-turn-helix domain; Region: HTH_18; pfam12833 937773006580 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 937773006581 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 937773006582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773006583 putative substrate translocation pore; other site 937773006584 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 937773006585 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773006586 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 937773006587 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 937773006588 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 937773006589 catalytic residue [active] 937773006590 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 937773006591 intersubunit interface [polypeptide binding]; other site 937773006592 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 937773006593 YodA lipocalin-like domain; Region: YodA; cl01365 937773006594 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 937773006595 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 937773006596 potential catalytic triad [active] 937773006597 conserved cys residue [active] 937773006598 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 937773006599 Sodium:solute symporter family; Region: SSF; cl00456 937773006600 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 937773006601 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 937773006602 active site 937773006603 non-prolyl cis peptide bond; other site 937773006604 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 937773006605 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 937773006606 homodimer interface [polypeptide binding]; other site 937773006607 substrate-cofactor binding pocket; other site 937773006608 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773006609 catalytic residue [active] 937773006610 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 937773006611 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 937773006612 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 937773006613 Class III ribonucleotide reductase; Region: RNR_III; cd01675 937773006614 effector binding site; other site 937773006615 active site 937773006616 Zn binding site [ion binding]; other site 937773006617 glycine loop; other site 937773006618 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 937773006619 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 937773006620 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 937773006621 active site 937773006622 phosphorylation site [posttranslational modification] 937773006623 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 937773006624 Helix-turn-helix domains; Region: HTH; cl00088 937773006625 Helix-turn-helix domains; Region: HTH; cl00088 937773006626 PRD domain; Region: PRD; cl15445 937773006627 PRD domain; Region: PRD; cl15445 937773006628 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 937773006629 P-loop; other site 937773006630 active site 937773006631 phosphorylation site [posttranslational modification] 937773006632 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 937773006633 active site 937773006634 phosphorylation site [posttranslational modification] 937773006635 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 937773006636 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 937773006637 dimer interface [polypeptide binding]; other site 937773006638 phosphorylation site [posttranslational modification] 937773006639 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 937773006640 ATP binding site [chemical binding]; other site 937773006641 Mg2+ binding site [ion binding]; other site 937773006642 G-X-G motif; other site 937773006643 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 937773006644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 937773006645 active site 937773006646 phosphorylation site [posttranslational modification] 937773006647 intermolecular recognition site; other site 937773006648 dimerization interface [polypeptide binding]; other site 937773006649 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 937773006650 DNA binding site [nucleotide binding] 937773006651 Electron transfer DM13; Region: DM13; cl02735 937773006652 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 937773006653 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 937773006654 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 937773006655 substrate binding site [chemical binding]; other site 937773006656 dimer interface [polypeptide binding]; other site 937773006657 ATP binding site [chemical binding]; other site 937773006658 Transcriptional regulators [Transcription]; Region: PurR; COG1609 937773006659 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 937773006660 DNA binding site [nucleotide binding] 937773006661 domain linker motif; other site 937773006662 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 937773006663 dimerization interface [polypeptide binding]; other site 937773006664 ligand binding site [chemical binding]; other site 937773006665 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 937773006666 putative catalytic residues [active] 937773006667 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773006668 active site 937773006669 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 937773006670 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 937773006671 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 937773006672 Walker A/P-loop; other site 937773006673 ATP binding site [chemical binding]; other site 937773006674 Q-loop/lid; other site 937773006675 ABC transporter signature motif; other site 937773006676 Walker B; other site 937773006677 D-loop; other site 937773006678 H-loop/switch region; other site 937773006679 NMT1-like family; Region: NMT1_2; cl15260 937773006680 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 937773006681 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 937773006682 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 937773006683 active site 937773006684 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773006685 Major Facilitator Superfamily; Region: MFS_1; pfam07690 937773006686 putative substrate translocation pore; other site 937773006687 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 937773006688 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 937773006689 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 937773006690 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 937773006691 AMP-binding enzyme; Region: AMP-binding; cl15778 937773006692 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 937773006693 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 937773006694 active site 937773006695 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 937773006696 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773006697 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 937773006698 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 937773006699 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 937773006700 substrate binding site [chemical binding]; other site 937773006701 oxyanion hole (OAH) forming residues; other site 937773006702 trimer interface [polypeptide binding]; other site 937773006703 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 937773006704 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 937773006705 dimer interface [polypeptide binding]; other site 937773006706 active site 937773006707 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 937773006708 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 937773006709 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 937773006710 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 937773006711 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 937773006712 accessory Sec system translocase SecA2; Region: secA2; TIGR03714 937773006713 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773006714 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 937773006715 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 937773006716 nucleotide binding region [chemical binding]; other site 937773006717 ATP-binding site [chemical binding]; other site 937773006718 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 937773006719 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 937773006720 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 937773006721 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 937773006722 accessory Sec system translocase SecY2; Region: acc_sec_Y2; TIGR02920 937773006723 SecY translocase; Region: SecY; pfam00344 937773006724 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 937773006725 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773006726 Predicted dehydrogenase [General function prediction only]; Region: COG0579 937773006727 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 937773006728 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 937773006729 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 937773006730 Phospholipid methyltransferase; Region: PEMT; cl00763 937773006731 N-acetyltransferase; Region: Acetyltransf_2; cl00949 937773006732 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 937773006733 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773006734 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 937773006735 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 937773006736 Predicted transcriptional regulator [Transcription]; Region: COG1959 937773006737 Helix-turn-helix domains; Region: HTH; cl00088 937773006738 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 937773006739 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 937773006740 Walker A/P-loop; other site 937773006741 ATP binding site [chemical binding]; other site 937773006742 Q-loop/lid; other site 937773006743 ABC transporter signature motif; other site 937773006744 Walker B; other site 937773006745 D-loop; other site 937773006746 H-loop/switch region; other site 937773006747 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 937773006748 FtsX-like permease family; Region: FtsX; cl15850 937773006749 Nucleoside recognition; Region: Gate; cl00486 937773006750 Nucleoside recognition; Region: Gate; cl00486 937773006751 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 937773006752 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 937773006753 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 937773006754 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 937773006755 N- and C-terminal domain interface [polypeptide binding]; other site 937773006756 active site 937773006757 MgATP binding site [chemical binding]; other site 937773006758 catalytic site [active] 937773006759 metal binding site [ion binding]; metal-binding site 937773006760 carbohydrate binding site [chemical binding]; other site 937773006761 aminotransferase A; Validated; Region: PRK07683 937773006762 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 937773006763 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773006764 homodimer interface [polypeptide binding]; other site 937773006765 catalytic residue [active] 937773006766 Sodium:solute symporter family; Region: SSF; cl00456 937773006767 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 937773006768 Ferritin-like domain; Region: Ferritin; pfam00210 937773006769 dimerization interface [polypeptide binding]; other site 937773006770 DPS ferroxidase diiron center [ion binding]; other site 937773006771 ion pore; other site 937773006772 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 937773006773 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 937773006774 tetramer interface [polypeptide binding]; other site 937773006775 heme binding pocket [chemical binding]; other site 937773006776 NADPH binding site [chemical binding]; other site 937773006777 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 937773006778 DinB superfamily; Region: DinB_2; pfam12867 937773006779 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 937773006780 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 937773006781 putative dimer interface [polypeptide binding]; other site 937773006782 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 937773006783 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 937773006784 catalytic residue [active] 937773006785 Helix-turn-helix domains; Region: HTH; cl00088 937773006786 CAAX protease self-immunity; Region: Abi; cl00558 937773006787 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 937773006788 DoxX; Region: DoxX; cl00976 937773006789 Predicted transcriptional regulator [Transcription]; Region: COG2378 937773006790 Helix-turn-helix domains; Region: HTH; cl00088 937773006791 WYL domain; Region: WYL; cl14852 937773006792 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 937773006793 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 937773006794 DXD motif; other site 937773006795 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 937773006796 OpgC protein; Region: OpgC_C; cl00792 937773006797 Acyltransferase family; Region: Acyl_transf_3; pfam01757 937773006798 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 937773006799 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 937773006800 active site 937773006801 6-carboxyhexanoate--CoA ligase; Region: BioW; cl00625 937773006802 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 937773006803 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 937773006804 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 937773006805 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 937773006806 catalytic residue [active] 937773006807 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 937773006808 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 937773006809 inhibitor-cofactor binding pocket; inhibition site 937773006810 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773006811 catalytic residue [active] 937773006812 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773006813 L-lactate permease; Region: Lactate_perm; cl00701 937773006814 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 937773006815 non-specific DNA binding site [nucleotide binding]; other site 937773006816 salt bridge; other site 937773006817 sequence-specific DNA binding site [nucleotide binding]; other site 937773006818 Domain of unknown function (DUF955); Region: DUF955; cl01076 937773006819 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 937773006820 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 937773006821 catalytic Zn binding site [ion binding]; other site 937773006822 structural Zn binding site [ion binding]; other site 937773006823 NAD(P) binding site [chemical binding]; other site 937773006824 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 937773006825 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 937773006826 non-specific DNA binding site [nucleotide binding]; other site 937773006827 salt bridge; other site 937773006828 sequence-specific DNA binding site [nucleotide binding]; other site 937773006829 Transcriptional regulator [Transcription]; Region: IclR; COG1414 937773006830 Helix-turn-helix domains; Region: HTH; cl00088 937773006831 Bacterial transcriptional regulator; Region: IclR; pfam01614 937773006832 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 937773006833 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773006834 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 937773006835 NAD(P) binding site [chemical binding]; other site 937773006836 LDH/MDH dimer interface [polypeptide binding]; other site 937773006837 substrate binding site [chemical binding]; other site 937773006838 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 937773006839 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 937773006840 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 937773006841 active site turn [active] 937773006842 phosphorylation site [posttranslational modification] 937773006843 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 937773006844 HPr interaction site; other site 937773006845 glycerol kinase (GK) interaction site [polypeptide binding]; other site 937773006846 active site 937773006847 phosphorylation site [posttranslational modification] 937773006848 YceI-like domain; Region: YceI; cl01001 937773006849 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 937773006850 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 937773006851 active site 937773006852 dimer interface [polypeptide binding]; other site 937773006853 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 937773006854 active pocket/dimerization site; other site 937773006855 active site 937773006856 phosphorylation site [posttranslational modification] 937773006857 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 937773006858 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 937773006859 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 937773006860 active site 937773006861 phosphorylation site [posttranslational modification] 937773006862 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 937773006863 beta-galactosidase; Provisional; Region: PLN03059 937773006864 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 937773006865 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 937773006866 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 937773006867 putative substrate binding site [chemical binding]; other site 937773006868 putative ATP binding site [chemical binding]; other site 937773006869 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 937773006870 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 937773006871 dimer interface [polypeptide binding]; other site 937773006872 active site 937773006873 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 937773006874 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 937773006875 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 937773006876 DNA-binding site [nucleotide binding]; DNA binding site 937773006877 UTRA domain; Region: UTRA; cl01230 937773006878 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 937773006879 Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905 937773006880 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 937773006881 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 937773006882 Walker A/P-loop; other site 937773006883 ATP binding site [chemical binding]; other site 937773006884 Q-loop/lid; other site 937773006885 ABC transporter signature motif; other site 937773006886 Walker B; other site 937773006887 D-loop; other site 937773006888 H-loop/switch region; other site 937773006889 EamA-like transporter family; Region: EamA; cl01037 937773006890 H+ Antiporter protein; Region: 2A0121; TIGR00900 937773006891 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 937773006892 Zn binding site [ion binding]; other site 937773006893 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 937773006894 Zn binding site [ion binding]; other site 937773006895 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 937773006896 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 937773006897 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 937773006898 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 937773006899 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 937773006900 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 937773006901 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 937773006902 Walker A/P-loop; other site 937773006903 ATP binding site [chemical binding]; other site 937773006904 Q-loop/lid; other site 937773006905 ABC transporter signature motif; other site 937773006906 Walker B; other site 937773006907 D-loop; other site 937773006908 H-loop/switch region; other site 937773006909 TOBE domain; Region: TOBE_2; cl01440 937773006910 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 937773006911 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 937773006912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 937773006913 dimer interface [polypeptide binding]; other site 937773006914 conserved gate region; other site 937773006915 putative PBP binding loops; other site 937773006916 ABC-ATPase subunit interface; other site 937773006917 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 937773006918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 937773006919 dimer interface [polypeptide binding]; other site 937773006920 conserved gate region; other site 937773006921 putative PBP binding loops; other site 937773006922 ABC-ATPase subunit interface; other site 937773006923 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 937773006924 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 937773006925 Ca binding site [ion binding]; other site 937773006926 active site 937773006927 catalytic site [active] 937773006928 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 937773006929 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 937773006930 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 937773006931 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 937773006932 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773006933 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 937773006934 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773006935 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 937773006936 Transcriptional regulators [Transcription]; Region: PurR; COG1609 937773006937 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 937773006938 DNA binding site [nucleotide binding] 937773006939 domain linker motif; other site 937773006940 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 937773006941 dimerization interface [polypeptide binding]; other site 937773006942 ligand binding site [chemical binding]; other site 937773006943 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 937773006944 Rib/alpha-like repeat; Region: Rib; cl07159 937773006945 Rib/alpha-like repeat; Region: Rib; cl07159 937773006946 Rib/alpha-like repeat; Region: Rib; cl07159 937773006947 Gram positive anchor; Region: Gram_pos_anchor; cl15427 937773006948 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 937773006949 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 937773006950 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 937773006951 amidase catalytic site [active] 937773006952 Zn binding residues [ion binding]; other site 937773006953 substrate binding site [chemical binding]; other site 937773006954 Tic20-like protein; Region: Tic20; pfam09685 937773006955 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 937773006956 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 937773006957 Walker A/P-loop; other site 937773006958 ATP binding site [chemical binding]; other site 937773006959 Q-loop/lid; other site 937773006960 ABC transporter signature motif; other site 937773006961 Walker B; other site 937773006962 D-loop; other site 937773006963 H-loop/switch region; other site 937773006964 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 937773006965 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 937773006966 Histidine kinase; Region: HisKA_3; pfam07730 937773006967 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 937773006968 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 937773006969 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 937773006970 active site 937773006971 phosphorylation site [posttranslational modification] 937773006972 intermolecular recognition site; other site 937773006973 dimerization interface [polypeptide binding]; other site 937773006974 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 937773006975 DNA binding residues [nucleotide binding] 937773006976 dimerization interface [polypeptide binding]; other site 937773006977 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 937773006978 Arginine repressor [Transcription]; Region: ArgR; COG1438 937773006979 Winged helix-turn helix; Region: HTH_33; pfam13592 937773006980 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 937773006981 Amidinotransferase; Region: Amidinotransf; cl12043 937773006982 ornithine carbamoyltransferase; Validated; Region: PRK02102 937773006983 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 937773006984 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773006985 arginine/ornithine antiporter; Region: arg_ornith_anti; TIGR03810 937773006986 Spore germination protein; Region: Spore_permease; cl15802 937773006987 carbamate kinase; Reviewed; Region: PRK12686 937773006988 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 937773006989 putative substrate binding site [chemical binding]; other site 937773006990 nucleotide binding site [chemical binding]; other site 937773006991 nucleotide binding site [chemical binding]; other site 937773006992 homodimer interface [polypeptide binding]; other site 937773006993 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 937773006994 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 937773006995 NAD-dependent deacetylase; Provisional; Region: PRK00481 937773006996 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 937773006997 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 937773006998 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 937773006999 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 937773007000 metal binding site [ion binding]; metal-binding site 937773007001 dimer interface [polypeptide binding]; other site 937773007002 Fic family protein [Function unknown]; Region: COG3177 937773007003 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 937773007004 Fic/DOC family; Region: Fic; cl00960 937773007005 Predicted membrane protein [Function unknown]; Region: COG4270 937773007006 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 937773007007 Prostaglandin dehydrogenases; Region: PGDH; cd05288 937773007008 NAD(P) binding site [chemical binding]; other site 937773007009 substrate binding site [chemical binding]; other site 937773007010 dimer interface [polypeptide binding]; other site 937773007011 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 937773007012 NADH(P)-binding; Region: NAD_binding_10; pfam13460 937773007013 NAD(P) binding site [chemical binding]; other site 937773007014 putative active site [active] 937773007015 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 937773007016 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 937773007017 potential catalytic triad [active] 937773007018 conserved cys residue [active] 937773007019 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 937773007020 DNA binding residues [nucleotide binding] 937773007021 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 937773007022 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 937773007023 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 937773007024 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 937773007025 K+-dependent Na+/Ca+ exchanger; Region: 2A1904; TIGR00927 937773007026 Gram positive anchor; Region: Gram_pos_anchor; cl15427 937773007027 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 937773007028 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 937773007029 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 937773007030 DNA-binding site [nucleotide binding]; DNA binding site 937773007031 UTRA domain; Region: UTRA; cl01230 937773007032 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 937773007033 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 937773007034 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 937773007035 L-type amino acid transporter; Region: 2A0308; TIGR00911 937773007036 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 937773007037 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 937773007038 tetramer interface [polypeptide binding]; other site 937773007039 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773007040 catalytic residue [active] 937773007041 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 937773007042 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 937773007043 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773007044 Predicted membrane protein [Function unknown]; Region: COG2311 937773007045 Protein of unknown function (DUF418); Region: DUF418; cl12135 937773007046 Protein of unknown function (DUF418); Region: DUF418; cl12135 937773007047 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 937773007048 putative active site [active] 937773007049 putative NTP binding site [chemical binding]; other site 937773007050 putative nucleic acid binding site [nucleotide binding]; other site 937773007051 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 937773007052 Transposase; Region: DDE_Tnp_ISL3; pfam01610 937773007053 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cl02713 937773007054 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773007055 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 937773007056 Abortive infection C-terminus; Region: Abi_C; pfam14355 937773007057 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 937773007058 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 937773007059 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 937773007060 YycH protein; Region: YycI; cl02015 937773007061 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 937773007062 YycH protein; Region: YycH; pfam07435 937773007063 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 937773007064 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 937773007065 dimerization interface [polypeptide binding]; other site 937773007066 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 937773007067 putative active site [active] 937773007068 heme pocket [chemical binding]; other site 937773007069 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 937773007070 dimer interface [polypeptide binding]; other site 937773007071 phosphorylation site [posttranslational modification] 937773007072 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 937773007073 ATP binding site [chemical binding]; other site 937773007074 Mg2+ binding site [ion binding]; other site 937773007075 G-X-G motif; other site 937773007076 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 937773007077 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 937773007078 active site 937773007079 phosphorylation site [posttranslational modification] 937773007080 intermolecular recognition site; other site 937773007081 dimerization interface [polypeptide binding]; other site 937773007082 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 937773007083 DNA binding site [nucleotide binding] 937773007084 SdpI/YhfL protein family; Region: SdpI; pfam13630 937773007085 Uncharacterized conserved protein [Function unknown]; Region: COG1284 937773007086 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 937773007087 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 937773007088 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 937773007089 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 937773007090 GDP-binding site [chemical binding]; other site 937773007091 ACT binding site; other site 937773007092 IMP binding site; other site 937773007093 replicative DNA helicase; Region: DnaB; TIGR00665 937773007094 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 937773007095 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 937773007096 Walker A motif; other site 937773007097 ATP binding site [chemical binding]; other site 937773007098 Walker B motif; other site 937773007099 DNA binding loops [nucleotide binding] 937773007100 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 937773007101 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 937773007102 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 937773007103 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 937773007104 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 937773007105 DHH family; Region: DHH; pfam01368 937773007106 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 937773007107 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 937773007108 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 937773007109 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 937773007110 AzlC protein; Region: AzlC; cl00570 937773007111 seryl-tRNA synthetase; Provisional; Region: PRK05431 937773007112 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 937773007113 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 937773007114 dimer interface [polypeptide binding]; other site 937773007115 active site 937773007116 motif 1; other site 937773007117 motif 2; other site 937773007118 motif 3; other site 937773007119 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 937773007120 active sites [active] 937773007121 tetramer interface [polypeptide binding]; other site 937773007122 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 937773007123 putative substrate binding site [chemical binding]; other site 937773007124 putative ATP binding site [chemical binding]; other site 937773007125 DNA gyrase subunit A; Validated; Region: PRK05560 937773007126 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 937773007127 CAP-like domain; other site 937773007128 active site 937773007129 primary dimer interface [polypeptide binding]; other site 937773007130 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 937773007131 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 937773007132 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 937773007133 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 937773007134 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 937773007135 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 937773007136 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 937773007137 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 937773007138 Mg2+ binding site [ion binding]; other site 937773007139 G-X-G motif; other site 937773007140 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 937773007141 anchoring element; other site 937773007142 dimer interface [polypeptide binding]; other site 937773007143 ATP binding site [chemical binding]; other site 937773007144 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 937773007145 active site 937773007146 putative metal-binding site [ion binding]; other site 937773007147 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 937773007148 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 937773007149 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 937773007150 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 937773007151 DNA polymerase III subunit beta; Validated; Region: PRK05643 937773007152 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 937773007153 putative DNA binding surface [nucleotide binding]; other site 937773007154 dimer interface [polypeptide binding]; other site 937773007155 beta-clamp/clamp loader binding surface; other site 937773007156 beta-clamp/translesion DNA polymerase binding surface; other site 937773007157 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 937773007158 DnaA N-terminal domain; Region: DnaA_N; pfam11638 937773007159 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 937773007160 Walker A motif; other site 937773007161 ATP binding site [chemical binding]; other site 937773007162 Walker B motif; other site 937773007163 arginine finger; other site 937773007164 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 937773007165 DnaA box-binding interface [nucleotide binding]; other site