-- dump date 20120504_162856 -- class Genbank::misc_feature -- table misc_feature_note -- id note 286636000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 286636000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 286636000003 Walker A motif; other site 286636000004 ATP binding site [chemical binding]; other site 286636000005 Walker B motif; other site 286636000006 arginine finger; other site 286636000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 286636000008 DnaA box-binding interface [nucleotide binding]; other site 286636000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 286636000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 286636000011 putative DNA binding surface [nucleotide binding]; other site 286636000012 dimer interface [polypeptide binding]; other site 286636000013 beta-clamp/clamp loader binding surface; other site 286636000014 beta-clamp/translesion DNA polymerase binding surface; other site 286636000015 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 286636000016 GTP-binding protein YchF; Reviewed; Region: PRK09601 286636000017 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 286636000018 G1 box; other site 286636000019 GTP/Mg2+ binding site [chemical binding]; other site 286636000020 Switch I region; other site 286636000021 G2 box; other site 286636000022 Switch II region; other site 286636000023 G3 box; other site 286636000024 G4 box; other site 286636000025 G5 box; other site 286636000026 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 286636000027 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 286636000028 putative active site [active] 286636000029 catalytic residue [active] 286636000030 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 286636000031 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 286636000032 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 286636000033 ATP binding site [chemical binding]; other site 286636000034 putative Mg++ binding site [ion binding]; other site 286636000035 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 286636000036 nucleotide binding region [chemical binding]; other site 286636000037 ATP-binding site [chemical binding]; other site 286636000038 TRCF domain; Region: TRCF; cl04088 286636000039 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 286636000040 Septum formation initiator; Region: DivIC; cl11433 286636000041 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 286636000042 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 286636000043 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 286636000044 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 286636000045 Ligand Binding Site [chemical binding]; other site 286636000046 B3/4 domain; Region: B3_4; cl11458 286636000047 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 286636000048 active site 286636000049 FtsH Extracellular; Region: FtsH_ext; pfam06480 286636000050 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 286636000051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 286636000052 Walker A motif; other site 286636000053 ATP binding site [chemical binding]; other site 286636000054 Walker B motif; other site 286636000055 arginine finger; other site 286636000056 Peptidase family M41; Region: Peptidase_M41; pfam01434 286636000057 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 286636000058 Helix-turn-helix domains; Region: HTH; cl00088 286636000059 Integrase core domain; Region: rve; cl01316 286636000060 amino acid transporter; Region: 2A0306; TIGR00909 286636000061 Spore germination protein; Region: Spore_permease; cl15802 286636000062 Spore germination protein; Region: Spore_permease; cl15802 286636000063 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 286636000064 NlpC/P60 family; Region: NLPC_P60; cl11438 286636000065 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 286636000066 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 286636000067 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 286636000068 active site 286636000069 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 286636000070 Recombination protein O N terminal; Region: RecO_N; pfam11967 286636000071 Recombination protein O C terminal; Region: RecO_C; pfam02565 286636000072 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 286636000073 Phage integrase family; Region: Phage_integrase; pfam00589 286636000074 Int/Topo IB signature motif; other site 286636000075 Domain of unknown function (DUF955); Region: DUF955; cl01076 286636000076 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 286636000077 non-specific DNA binding site [nucleotide binding]; other site 286636000078 salt bridge; other site 286636000079 sequence-specific DNA binding site [nucleotide binding]; other site 286636000080 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 286636000081 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 286636000082 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 286636000083 active site 286636000084 DNA binding site [nucleotide binding] 286636000085 catalytic site [active] 286636000086 D5 N terminal like; Region: D5_N; cl07360 286636000087 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 286636000088 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 286636000089 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 286636000090 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 286636000091 ATP binding site [chemical binding]; other site 286636000092 putative Mg++ binding site [ion binding]; other site 286636000093 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 286636000094 nucleotide binding region [chemical binding]; other site 286636000095 ATP-binding site [chemical binding]; other site 286636000096 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 286636000097 Terminase small subunit; Region: Terminase_2; cl01513 286636000098 Phage terminase large subunit; Region: Terminase_3; cl12054 286636000099 Terminase-like family; Region: Terminase_6; pfam03237 286636000100 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 286636000101 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 286636000102 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 286636000103 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 286636000104 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 286636000105 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 286636000106 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 286636000107 Phage major tail protein 2; Region: Phage_tail_2; cl11463 286636000108 Phage protein; Region: DUF3647; cl10335 286636000109 tape measure domain; Region: tape_meas_nterm; TIGR02675 286636000110 Phage tail protein; Region: Sipho_tail; cl11462 286636000111 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 286636000112 Hyaluronidase protein (HylP); Region: Hyaluronidase_1; pfam07212 286636000113 gp58-like protein; Region: Gp58; pfam07902 286636000114 Protein of unknown function (DUF1617); Region: DUF1617; pfam07761 286636000115 Bacteriophage holin; Region: Phage_holin_1; cl02344 286636000116 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 286636000117 NlpC/P60 family; Region: NLPC_P60; cl11438 286636000118 Bacterial SH3 domain; Region: SH3_3; cl02551 286636000119 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 286636000120 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 286636000121 Phosphopantetheine attachment site; Region: PP-binding; cl09936 286636000122 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 286636000123 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 286636000124 ATP binding site [chemical binding]; other site 286636000125 active site 286636000126 substrate binding site [chemical binding]; other site 286636000127 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 286636000128 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 286636000129 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 286636000130 dimerization interface [polypeptide binding]; other site 286636000131 ATP binding site [chemical binding]; other site 286636000132 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 286636000133 dimerization interface [polypeptide binding]; other site 286636000134 ATP binding site [chemical binding]; other site 286636000135 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 286636000136 putative active site [active] 286636000137 catalytic triad [active] 286636000138 amidophosphoribosyltransferase; Provisional; Region: PRK07272 286636000139 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 286636000140 active site 286636000141 tetramer interface [polypeptide binding]; other site 286636000142 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 286636000143 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 286636000144 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 286636000145 dimerization interface [polypeptide binding]; other site 286636000146 putative ATP binding site [chemical binding]; other site 286636000147 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 286636000148 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 286636000149 active site 286636000150 substrate binding site [chemical binding]; other site 286636000151 cosubstrate binding site; other site 286636000152 catalytic site [active] 286636000153 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 286636000154 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 286636000155 purine monophosphate binding site [chemical binding]; other site 286636000156 dimer interface [polypeptide binding]; other site 286636000157 putative catalytic residues [active] 286636000158 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 286636000159 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 286636000160 Surface antigen [General function prediction only]; Region: COG3942 286636000161 NlpC/P60 family; Region: NLPC_P60; cl11438 286636000162 Bacterial SH3 domain; Region: SH3_3; cl02551 286636000163 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 286636000164 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 286636000165 ATP-grasp domain; Region: ATP-grasp_4; cl03087 286636000166 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 286636000167 AIR carboxylase; Region: AIRC; cl00310 286636000168 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 286636000169 ATP-grasp domain; Region: ATP-grasp_4; cl03087 286636000170 adenylosuccinate lyase; Provisional; Region: PRK07492 286636000171 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 286636000172 tetramer interface [polypeptide binding]; other site 286636000173 active site 286636000174 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 286636000175 non-specific DNA binding site [nucleotide binding]; other site 286636000176 salt bridge; other site 286636000177 sequence-specific DNA binding site [nucleotide binding]; other site 286636000178 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 286636000179 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 286636000180 Walker A motif; other site 286636000181 ATP binding site [chemical binding]; other site 286636000182 Walker B motif; other site 286636000183 arginine finger; other site 286636000184 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 286636000185 Low molecular weight phosphatase family; Region: LMWPc; cd00115 286636000186 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 286636000187 active site 286636000188 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 286636000189 MORN repeat; Region: MORN; cl14787 286636000190 OpgC protein; Region: OpgC_C; cl00792 286636000191 Acyltransferase family; Region: Acyl_transf_3; pfam01757 286636000192 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 286636000193 catalytic triad [active] 286636000194 catalytic triad [active] 286636000195 oxyanion hole [active] 286636000196 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 286636000197 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 286636000198 putative catalytic cysteine [active] 286636000199 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 286636000200 putative active site [active] 286636000201 metal binding site [ion binding]; metal-binding site 286636000202 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 286636000203 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 286636000204 NAD binding site [chemical binding]; other site 286636000205 substrate binding site [chemical binding]; other site 286636000206 catalytic Zn binding site [ion binding]; other site 286636000207 tetramer interface [polypeptide binding]; other site 286636000208 structural Zn binding site [ion binding]; other site 286636000209 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 286636000210 MatE; Region: MatE; cl10513 286636000211 MatE; Region: MatE; cl10513 286636000212 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 286636000213 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 286636000214 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 286636000215 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 286636000216 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 286636000217 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 286636000218 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 286636000219 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 286636000220 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 286636000221 putative translocon binding site; other site 286636000222 protein-rRNA interface [nucleotide binding]; other site 286636000223 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 286636000224 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 286636000225 G-X-X-G motif; other site 286636000226 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 286636000227 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 286636000228 23S rRNA interface [nucleotide binding]; other site 286636000229 5S rRNA interface [nucleotide binding]; other site 286636000230 putative antibiotic binding site [chemical binding]; other site 286636000231 L25 interface [polypeptide binding]; other site 286636000232 L27 interface [polypeptide binding]; other site 286636000233 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 286636000234 L23 interface [polypeptide binding]; other site 286636000235 signal recognition particle (SRP54) interaction site; other site 286636000236 trigger factor interaction site; other site 286636000237 23S rRNA interface [nucleotide binding]; other site 286636000238 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 286636000239 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 286636000240 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 286636000241 KOW motif; Region: KOW; cl00354 286636000242 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 286636000243 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 286636000244 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 286636000245 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 286636000246 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 286636000247 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 286636000248 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 286636000249 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 286636000250 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 286636000251 5S rRNA interface [nucleotide binding]; other site 286636000252 L27 interface [polypeptide binding]; other site 286636000253 23S rRNA interface [nucleotide binding]; other site 286636000254 L5 interface [polypeptide binding]; other site 286636000255 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 286636000256 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 286636000257 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 286636000258 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 286636000259 23S rRNA binding site [nucleotide binding]; other site 286636000260 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 286636000261 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 286636000262 SecY translocase; Region: SecY; pfam00344 286636000263 adenylate kinase; Reviewed; Region: adk; PRK00279 286636000264 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 286636000265 AMP-binding site [chemical binding]; other site 286636000266 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 286636000267 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 286636000268 RNA binding site [nucleotide binding]; other site 286636000269 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 286636000270 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 286636000271 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 286636000272 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 286636000273 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 286636000274 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 286636000275 alphaNTD homodimer interface [polypeptide binding]; other site 286636000276 alphaNTD - beta interaction site [polypeptide binding]; other site 286636000277 alphaNTD - beta' interaction site [polypeptide binding]; other site 286636000278 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 286636000279 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 286636000280 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 286636000281 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 286636000282 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 286636000283 Helix-turn-helix domains; Region: HTH; cl00088 286636000284 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 286636000285 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 286636000286 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 286636000287 ABC-ATPase subunit interface; other site 286636000288 dimer interface [polypeptide binding]; other site 286636000289 putative PBP binding regions; other site 286636000290 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 286636000291 nucleotide binding site/active site [active] 286636000292 HIT family signature motif; other site 286636000293 catalytic residue [active] 286636000294 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 286636000295 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 286636000296 active site 286636000297 HIGH motif; other site 286636000298 dimer interface [polypeptide binding]; other site 286636000299 KMSKS motif; other site 286636000300 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 286636000301 RNA binding surface [nucleotide binding]; other site 286636000302 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 286636000303 Transglycosylase; Region: Transgly; cl07896 286636000304 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 286636000305 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 286636000306 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 286636000307 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591 286636000308 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 286636000309 RPB1 interaction site [polypeptide binding]; other site 286636000310 RPB10 interaction site [polypeptide binding]; other site 286636000311 RPB11 interaction site [polypeptide binding]; other site 286636000312 RPB3 interaction site [polypeptide binding]; other site 286636000313 RPB12 interaction site [polypeptide binding]; other site 286636000314 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 286636000315 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 286636000316 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 286636000317 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 286636000318 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 286636000319 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 286636000320 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 286636000321 G-loop; other site 286636000322 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 286636000323 DNA binding site [nucleotide binding] 286636000324 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 286636000325 Protein of unknown function (DUF1033); Region: DUF1033; cl11549 286636000326 Type II/IV secretion system protein; Region: T2SE; pfam00437 286636000327 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 286636000328 Walker A motif; other site 286636000329 ATP binding site [chemical binding]; other site 286636000330 Walker B motif; other site 286636000331 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 286636000332 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 286636000333 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 286636000334 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 286636000335 Type II secretory pathway pseudopilin; Region: PulG; pfam11773 286636000336 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 286636000337 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 286636000338 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636000339 Acetokinase family; Region: Acetate_kinase; cl01029 286636000340 propionate/acetate kinase; Provisional; Region: PRK12379 286636000341 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 286636000342 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636000343 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 286636000344 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 286636000345 metal binding site [ion binding]; metal-binding site 286636000346 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 286636000347 Helix-turn-helix domains; Region: HTH; cl00088 286636000348 Integrase core domain; Region: rve; cl01316 286636000349 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 286636000350 catalytic residues [active] 286636000351 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 286636000352 putative tRNA-binding site [nucleotide binding]; other site 286636000353 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 286636000354 dimer interface [polypeptide binding]; other site 286636000355 ssDNA binding site [nucleotide binding]; other site 286636000356 tetramer (dimer of dimers) interface [polypeptide binding]; other site 286636000357 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 286636000358 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 286636000359 Substrate-binding site [chemical binding]; other site 286636000360 Substrate specificity [chemical binding]; other site 286636000361 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 286636000362 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 286636000363 FMN binding site [chemical binding]; other site 286636000364 active site 286636000365 catalytic residues [active] 286636000366 substrate binding site [chemical binding]; other site 286636000367 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 286636000368 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 286636000369 dimerization interface [polypeptide binding]; other site 286636000370 domain crossover interface; other site 286636000371 redox-dependent activation switch; other site 286636000372 Helix-turn-helix domains; Region: HTH; cl00088 286636000373 Helix-turn-helix domains; Region: HTH; cl00088 286636000374 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 286636000375 Fibronectin-binding protein signal sequence; Region: Fb_signal; pfam08341 286636000376 TQXA domain; Region: TQXA_dom; TIGR03934 286636000377 Fibronectin binding repeat; Region: Fn_bind; pfam02986 286636000378 Fibronectin binding repeat; Region: Fn_bind; pfam02986 286636000379 Fibronectin binding repeat; Region: Fn_bind; pfam02986 286636000380 Fibronectin binding repeat; Region: Fn_bind; pfam02986 286636000381 Fibronectin binding repeat; Region: Fn_bind; pfam02986 286636000382 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 286636000383 metal ion-dependent adhesion site (MIDAS); other site 286636000384 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 286636000385 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 286636000386 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 286636000387 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 286636000388 active site 286636000389 catalytic site [active] 286636000390 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 286636000391 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 286636000392 Helix-turn-helix domains; Region: HTH; cl00088 286636000393 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 286636000394 putative acyltransferase; Provisional; Region: PRK05790 286636000395 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 286636000396 dimer interface [polypeptide binding]; other site 286636000397 active site 286636000398 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 286636000399 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 286636000400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 286636000401 YheO-like PAS domain; Region: PAS_6; pfam08348 286636000402 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 286636000403 homotrimer interaction site [polypeptide binding]; other site 286636000404 putative active site [active] 286636000405 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 286636000406 V-type ATP synthase subunit I; Validated; Region: PRK05771 286636000407 V-type ATP synthase subunit K; Validated; Region: PRK06558 286636000408 ATP synthase subunit C; Region: ATP-synt_C; cl00466 286636000409 ATP synthase subunit C; Region: ATP-synt_C; cl00466 286636000410 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 286636000411 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 286636000412 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; cl00632 286636000413 V-type ATP synthase subunit A; Provisional; Region: PRK04192 286636000414 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 286636000415 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 286636000416 Walker A motif/ATP binding site; other site 286636000417 Walker B motif; other site 286636000418 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 286636000419 V-type ATP synthase subunit B; Provisional; Region: PRK04196 286636000420 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 286636000421 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 286636000422 Walker A motif homologous position; other site 286636000423 Walker B motif; other site 286636000424 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 286636000425 ATP synthase subunit D; Region: ATP-synt_D; cl00613 286636000426 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 286636000427 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 286636000428 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 286636000429 GDP-binding site [chemical binding]; other site 286636000430 ACT binding site; other site 286636000431 IMP binding site; other site 286636000432 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 286636000433 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 286636000434 ligand binding site [chemical binding]; other site 286636000435 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 286636000436 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 286636000437 putative homodimer interface [polypeptide binding]; other site 286636000438 KOW motif; Region: KOW; cl00354 286636000439 Nicotine adenine dinucleotide glycohydrolase (NADase); Region: NADase_NGA; pfam07461 286636000440 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 286636000441 cystathionine beta-lyase; Provisional; Region: PRK08064 286636000442 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 286636000443 homodimer interface [polypeptide binding]; other site 286636000444 substrate-cofactor binding pocket; other site 286636000445 pyridoxal 5'-phosphate binding site [chemical binding]; other site 286636000446 catalytic residue [active] 286636000447 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 286636000448 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 286636000449 HIGH motif; other site 286636000450 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 286636000451 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 286636000452 active site 286636000453 KMSKS motif; other site 286636000454 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 286636000455 tRNA binding surface [nucleotide binding]; other site 286636000456 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 286636000457 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 286636000458 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 286636000459 P-loop; other site 286636000460 active site 286636000461 phosphorylation site [posttranslational modification] 286636000462 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 286636000463 active site 286636000464 phosphorylation site [posttranslational modification] 286636000465 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 286636000466 active site 286636000467 dimer interface [polypeptide binding]; other site 286636000468 magnesium binding site [ion binding]; other site 286636000469 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 286636000470 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 286636000471 AP (apurinic/apyrimidinic) site pocket; other site 286636000472 DNA interaction; other site 286636000473 Metal-binding active site; metal-binding site 286636000474 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 286636000475 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 286636000476 intersubunit interface [polypeptide binding]; other site 286636000477 active site 286636000478 Zn2+ binding site [ion binding]; other site 286636000479 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 286636000480 Helix-turn-helix domains; Region: HTH; cl00088 286636000481 PRD domain; Region: PRD; cl15445 286636000482 PRD domain; Region: PRD; cl15445 286636000483 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 286636000484 P-loop; other site 286636000485 active site 286636000486 phosphorylation site [posttranslational modification] 286636000487 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 286636000488 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 286636000489 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 286636000490 Walker A/P-loop; other site 286636000491 ATP binding site [chemical binding]; other site 286636000492 Q-loop/lid; other site 286636000493 ABC transporter signature motif; other site 286636000494 Walker B; other site 286636000495 D-loop; other site 286636000496 H-loop/switch region; other site 286636000497 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 286636000498 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 286636000499 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 286636000500 dimer interface [polypeptide binding]; other site 286636000501 conserved gate region; other site 286636000502 putative PBP binding loops; other site 286636000503 ABC-ATPase subunit interface; other site 286636000504 NMT1-like family; Region: NMT1_2; cl15260 286636000505 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 286636000506 DNA polymerase I; Provisional; Region: PRK05755 286636000507 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 286636000508 active site 286636000509 metal binding site 1 [ion binding]; metal-binding site 286636000510 putative 5' ssDNA interaction site; other site 286636000511 metal binding site 3; metal-binding site 286636000512 metal binding site 2 [ion binding]; metal-binding site 286636000513 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 286636000514 putative DNA binding site [nucleotide binding]; other site 286636000515 putative metal binding site [ion binding]; other site 286636000516 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 286636000517 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 286636000518 active site 286636000519 DNA binding site [nucleotide binding] 286636000520 catalytic site [active] 286636000521 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636000522 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 286636000523 metal binding site 2 [ion binding]; metal-binding site 286636000524 putative DNA binding helix; other site 286636000525 metal binding site 1 [ion binding]; metal-binding site 286636000526 dimer interface [polypeptide binding]; other site 286636000527 structural Zn2+ binding site [ion binding]; other site 286636000528 Protein of unknown function (DUF975); Region: DUF975; cl10504 286636000529 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 286636000530 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 286636000531 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 286636000532 CHY zinc finger; Region: zf-CHY; pfam05495 286636000533 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 286636000534 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 286636000535 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 286636000536 nucleoside/Zn binding site; other site 286636000537 dimer interface [polypeptide binding]; other site 286636000538 catalytic motif [active] 286636000539 Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279 286636000540 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 286636000541 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 286636000542 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 286636000543 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 286636000544 active site 286636000545 dimer interface [polypeptide binding]; other site 286636000546 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 286636000547 dimer interface [polypeptide binding]; other site 286636000548 active site 286636000549 Helix-turn-helix domains; Region: HTH; cl00088 286636000550 Helix-turn-helix domains; Region: HTH; cl00088 286636000551 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 286636000552 Rhomboid family; Region: Rhomboid; cl11446 286636000553 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 286636000554 active site 286636000555 tetramer interface; other site 286636000556 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 286636000557 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636000558 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 286636000559 Helix-turn-helix domains; Region: HTH; cl00088 286636000560 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 286636000561 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 286636000562 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 286636000563 Walker A/P-loop; other site 286636000564 ATP binding site [chemical binding]; other site 286636000565 Q-loop/lid; other site 286636000566 ABC transporter signature motif; other site 286636000567 Walker B; other site 286636000568 D-loop; other site 286636000569 H-loop/switch region; other site 286636000570 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 286636000571 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 286636000572 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 286636000573 Walker A/P-loop; other site 286636000574 ATP binding site [chemical binding]; other site 286636000575 Q-loop/lid; other site 286636000576 ABC transporter signature motif; other site 286636000577 Walker B; other site 286636000578 D-loop; other site 286636000579 H-loop/switch region; other site 286636000580 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 286636000581 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 286636000582 trimer interface [polypeptide binding]; other site 286636000583 active site 286636000584 DNA repair protein RadA; Provisional; Region: PRK11823 286636000585 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 286636000586 Walker A motif/ATP binding site; other site 286636000587 ATP binding site [chemical binding]; other site 286636000588 Walker B motif; other site 286636000589 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 286636000590 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 286636000591 active site clefts [active] 286636000592 zinc binding site [ion binding]; other site 286636000593 dimer interface [polypeptide binding]; other site 286636000594 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 286636000595 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 286636000596 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 286636000597 active site 286636000598 HIGH motif; other site 286636000599 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 286636000600 active site 286636000601 KMSKS motif; other site 286636000602 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 286636000603 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 286636000604 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 286636000605 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 286636000606 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 286636000607 active site 286636000608 phosphorylation site [posttranslational modification] 286636000609 intermolecular recognition site; other site 286636000610 dimerization interface [polypeptide binding]; other site 286636000611 LytTr DNA-binding domain; Region: LytTR; cl04498 286636000612 Ribonuclease P; Region: Ribonuclease_P; cl00457 286636000613 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 286636000614 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 286636000615 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 286636000616 G-X-X-G motif; other site 286636000617 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 286636000618 RxxxH motif; other site 286636000619 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 286636000620 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 286636000621 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 286636000622 putative active site cavity [active] 286636000623 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 286636000624 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 286636000625 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 286636000626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 286636000627 dimer interface [polypeptide binding]; other site 286636000628 ABC-ATPase subunit interface; other site 286636000629 putative PBP binding loops; other site 286636000630 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 286636000631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 286636000632 dimer interface [polypeptide binding]; other site 286636000633 conserved gate region; other site 286636000634 putative PBP binding loops; other site 286636000635 ABC-ATPase subunit interface; other site 286636000636 Protein of unknown function, DUF624; Region: DUF624; cl02369 286636000637 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 286636000638 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 286636000639 catalytic residue [active] 286636000640 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 286636000641 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 286636000642 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 286636000643 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 286636000644 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 286636000645 putative active site [active] 286636000646 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 286636000647 active site 286636000648 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 286636000649 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 286636000650 putative active site [active] 286636000651 putative metal binding site [ion binding]; other site 286636000652 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 286636000653 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636000654 GTPase RsgA; Reviewed; Region: PRK00098 286636000655 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs...; Region: YjeQ_engC; cd01854 286636000656 GTPase/OB domain interface [polypeptide binding]; other site 286636000657 GTPase/Zn-binding domain interface [polypeptide binding]; other site 286636000658 GTP/Mg2+ binding site [chemical binding]; other site 286636000659 G4 box; other site 286636000660 G1 box; other site 286636000661 Switch I region; other site 286636000662 G2 box; other site 286636000663 G3 box; other site 286636000664 Switch II region; other site 286636000665 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 286636000666 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 286636000667 substrate binding site [chemical binding]; other site 286636000668 hexamer interface [polypeptide binding]; other site 286636000669 metal binding site [ion binding]; metal-binding site 286636000670 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 286636000671 Thiamine pyrophosphokinase; Region: TPK; cd07995 286636000672 active site 286636000673 dimerization interface [polypeptide binding]; other site 286636000674 thiamine binding site [chemical binding]; other site 286636000675 RmuC family; Region: RmuC; pfam02646 286636000676 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 286636000677 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 286636000678 generic binding surface II; other site 286636000679 generic binding surface I; other site 286636000680 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 286636000681 pur operon repressor; Provisional; Region: PRK09213 286636000682 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 286636000683 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 286636000684 active site 286636000685 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 286636000686 S17 interaction site [polypeptide binding]; other site 286636000687 S8 interaction site; other site 286636000688 16S rRNA interaction site [nucleotide binding]; other site 286636000689 streptomycin interaction site [chemical binding]; other site 286636000690 23S rRNA interaction site [nucleotide binding]; other site 286636000691 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 286636000692 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 286636000693 elongation factor G; Reviewed; Region: PRK00007 286636000694 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved so...; Region: EF-G; cd01886 286636000695 G1 box; other site 286636000696 putative GEF interaction site [polypeptide binding]; other site 286636000697 GTP/Mg2+ binding site [chemical binding]; other site 286636000698 Switch I region; other site 286636000699 G2 box; other site 286636000700 G3 box; other site 286636000701 Switch II region; other site 286636000702 G4 box; other site 286636000703 G5 box; other site 286636000704 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 286636000705 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 286636000706 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 286636000707 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636000708 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 286636000709 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 286636000710 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 286636000711 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 286636000712 Walker A/P-loop; other site 286636000713 ATP binding site [chemical binding]; other site 286636000714 Q-loop/lid; other site 286636000715 ABC transporter signature motif; other site 286636000716 Walker B; other site 286636000717 D-loop; other site 286636000718 H-loop/switch region; other site 286636000719 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 286636000720 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 286636000721 substrate binding pocket [chemical binding]; other site 286636000722 membrane-bound complex binding site; other site 286636000723 hinge residues; other site 286636000724 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 286636000725 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 286636000726 dimer interface [polypeptide binding]; other site 286636000727 conserved gate region; other site 286636000728 putative PBP binding loops; other site 286636000729 ABC-ATPase subunit interface; other site 286636000730 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 286636000731 Bacitracin resistance protein BacA; Region: BacA; cl00858 286636000732 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 286636000733 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 286636000734 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 286636000735 Mg++ binding site [ion binding]; other site 286636000736 putative catalytic motif [active] 286636000737 substrate binding site [chemical binding]; other site 286636000738 FeS assembly ATPase SufC; Region: sufC; TIGR01978 286636000739 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 286636000740 Walker A/P-loop; other site 286636000741 ATP binding site [chemical binding]; other site 286636000742 Q-loop/lid; other site 286636000743 ABC transporter signature motif; other site 286636000744 Walker B; other site 286636000745 D-loop; other site 286636000746 H-loop/switch region; other site 286636000747 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 286636000748 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 286636000749 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 286636000750 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 286636000751 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 286636000752 catalytic residue [active] 286636000753 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 286636000754 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 286636000755 trimerization site [polypeptide binding]; other site 286636000756 active site 286636000757 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 286636000758 FeS assembly protein SufB; Region: sufB; TIGR01980 286636000759 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 286636000760 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 286636000761 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 286636000762 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 286636000763 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 286636000764 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 286636000765 peptide binding site [polypeptide binding]; other site 286636000766 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 286636000767 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 286636000768 dimer interface [polypeptide binding]; other site 286636000769 conserved gate region; other site 286636000770 putative PBP binding loops; other site 286636000771 ABC-ATPase subunit interface; other site 286636000772 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 286636000773 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 286636000774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 286636000775 dimer interface [polypeptide binding]; other site 286636000776 conserved gate region; other site 286636000777 putative PBP binding loops; other site 286636000778 ABC-ATPase subunit interface; other site 286636000779 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 286636000780 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 286636000781 Walker A/P-loop; other site 286636000782 ATP binding site [chemical binding]; other site 286636000783 Q-loop/lid; other site 286636000784 ABC transporter signature motif; other site 286636000785 Walker B; other site 286636000786 D-loop; other site 286636000787 H-loop/switch region; other site 286636000788 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 286636000789 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 286636000790 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 286636000791 Walker A/P-loop; other site 286636000792 ATP binding site [chemical binding]; other site 286636000793 Q-loop/lid; other site 286636000794 ABC transporter signature motif; other site 286636000795 Walker B; other site 286636000796 D-loop; other site 286636000797 H-loop/switch region; other site 286636000798 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 286636000799 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 286636000800 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 286636000801 active site 286636000802 motif I; other site 286636000803 motif II; other site 286636000804 GTPase YqeH; Provisional; Region: PRK13796 286636000805 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 286636000806 GTP/Mg2+ binding site [chemical binding]; other site 286636000807 G4 box; other site 286636000808 G5 box; other site 286636000809 G1 box; other site 286636000810 Switch I region; other site 286636000811 G2 box; other site 286636000812 G3 box; other site 286636000813 Switch II region; other site 286636000814 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 286636000815 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 286636000816 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 286636000817 active site 286636000818 (T/H)XGH motif; other site 286636000819 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 286636000820 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 286636000821 Oligomerisation domain; Region: Oligomerisation; cl00519 286636000822 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 286636000823 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 286636000824 S-adenosylmethionine binding site [chemical binding]; other site 286636000825 hypothetical protein; Provisional; Region: PRK13670 286636000826 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 286636000827 Transcriptional regulator; Region: Transcrip_reg; cl00361 286636000828 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 286636000829 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 286636000830 substrate binding pocket [chemical binding]; other site 286636000831 membrane-bound complex binding site; other site 286636000832 hinge residues; other site 286636000833 NMT1-like family; Region: NMT1_2; cl15260 286636000834 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 286636000835 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 286636000836 Walker A/P-loop; other site 286636000837 ATP binding site [chemical binding]; other site 286636000838 Q-loop/lid; other site 286636000839 ABC transporter signature motif; other site 286636000840 Walker B; other site 286636000841 D-loop; other site 286636000842 H-loop/switch region; other site 286636000843 NIL domain; Region: NIL; cl09633 286636000844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 286636000845 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 286636000846 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 286636000847 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 286636000848 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636000849 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 286636000850 Cation transport protein; Region: TrkH; cl10514 286636000851 Methyltransferase domain; Region: Methyltransf_31; pfam13847 286636000852 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 286636000853 S-adenosylmethionine binding site [chemical binding]; other site 286636000854 LemA family; Region: LemA; cl00742 286636000855 Peptidase family M48; Region: Peptidase_M48; cl12018 286636000856 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 286636000857 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 286636000858 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 286636000859 active site 286636000860 phosphorylation site [posttranslational modification] 286636000861 intermolecular recognition site; other site 286636000862 dimerization interface [polypeptide binding]; other site 286636000863 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 286636000864 DNA binding site [nucleotide binding] 286636000865 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 286636000866 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 286636000867 dimerization interface [polypeptide binding]; other site 286636000868 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 286636000869 dimer interface [polypeptide binding]; other site 286636000870 phosphorylation site [posttranslational modification] 286636000871 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 286636000872 ATP binding site [chemical binding]; other site 286636000873 Mg2+ binding site [ion binding]; other site 286636000874 G-X-G motif; other site 286636000875 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 286636000876 ATP cone domain; Region: ATP-cone; pfam03477 286636000877 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 286636000878 primosomal protein DnaI; Reviewed; Region: PRK08939 286636000879 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 286636000880 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 286636000881 Walker A motif; other site 286636000882 ATP binding site [chemical binding]; other site 286636000883 Walker B motif; other site 286636000884 GTP-binding protein Der; Reviewed; Region: PRK00093 286636000885 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 286636000886 G1 box; other site 286636000887 GTP/Mg2+ binding site [chemical binding]; other site 286636000888 Switch I region; other site 286636000889 G2 box; other site 286636000890 Switch II region; other site 286636000891 G3 box; other site 286636000892 G4 box; other site 286636000893 G5 box; other site 286636000894 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 286636000895 G1 box; other site 286636000896 GTP/Mg2+ binding site [chemical binding]; other site 286636000897 Switch I region; other site 286636000898 G2 box; other site 286636000899 G3 box; other site 286636000900 Switch II region; other site 286636000901 G4 box; other site 286636000902 G5 box; other site 286636000903 SWIM zinc finger; Region: SWIM; cl15408 286636000904 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 286636000905 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 286636000906 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 286636000907 ATP binding site [chemical binding]; other site 286636000908 putative Mg++ binding site [ion binding]; other site 286636000909 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 286636000910 nucleotide binding region [chemical binding]; other site 286636000911 ATP-binding site [chemical binding]; other site 286636000912 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 286636000913 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 286636000914 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 286636000915 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 286636000916 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 286636000917 YceG-like family; Region: YceG; pfam02618 286636000918 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 286636000919 dimerization interface [polypeptide binding]; other site 286636000920 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 286636000921 domain; Region: GreA_GreB_N; pfam03449 286636000922 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 286636000923 OxaA-like protein precursor; Provisional; Region: PRK02463 286636000924 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 286636000925 Acylphosphatase; Region: Acylphosphatase; cl00551 286636000926 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 286636000927 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 286636000928 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 286636000929 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 286636000930 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 286636000931 Uncharacterized protein family (UPF0154); Region: UPF0154; cl01536 286636000932 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 286636000933 putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491 286636000934 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 286636000935 active site 286636000936 dimerization interface [polypeptide binding]; other site 286636000937 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 286636000938 active site 286636000939 metal binding site [ion binding]; metal-binding site 286636000940 homotetramer interface [polypeptide binding]; other site 286636000941 FOG: CBS domain [General function prediction only]; Region: COG0517 286636000942 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 286636000943 site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436 286636000944 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 286636000945 DNA binding site [nucleotide binding] 286636000946 Int/Topo IB signature motif; other site 286636000947 active site 286636000948 catalytic residues [active] 286636000949 ScpA/B protein; Region: ScpA_ScpB; cl00598 286636000950 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 286636000951 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 286636000952 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 286636000953 RNA binding surface [nucleotide binding]; other site 286636000954 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 286636000955 active site 286636000956 Haemolytic domain; Region: Haemolytic; cl00506 286636000957 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 286636000958 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 286636000959 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 286636000960 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 286636000961 active site 286636000962 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 286636000963 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636000964 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636000965 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 286636000966 Domain of unknown function DUF21; Region: DUF21; pfam01595 286636000967 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 286636000968 Transporter associated domain; Region: CorC_HlyC; cl08393 286636000969 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 286636000970 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 286636000971 FeS/SAM binding site; other site 286636000972 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 286636000973 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 286636000974 DHHA2 domain; Region: DHHA2; pfam02833 286636000975 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 286636000976 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 286636000977 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 286636000978 ABC-ATPase subunit interface; other site 286636000979 dimer interface [polypeptide binding]; other site 286636000980 putative PBP binding regions; other site 286636000981 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 286636000982 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 286636000983 ABC-ATPase subunit interface; other site 286636000984 dimer interface [polypeptide binding]; other site 286636000985 putative PBP binding regions; other site 286636000986 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 286636000987 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 286636000988 putative ligand binding residues [chemical binding]; other site 286636000989 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 286636000990 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 286636000991 Walker A/P-loop; other site 286636000992 ATP binding site [chemical binding]; other site 286636000993 Q-loop/lid; other site 286636000994 ABC transporter signature motif; other site 286636000995 Walker B; other site 286636000996 D-loop; other site 286636000997 H-loop/switch region; other site 286636000998 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 286636000999 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 286636001000 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 286636001001 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 286636001002 MatE; Region: MatE; cl10513 286636001003 MviN-like protein; Region: MVIN; pfam03023 286636001004 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 286636001005 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 286636001006 oligomer interface [polypeptide binding]; other site 286636001007 active site residues [active] 286636001008 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 286636001009 thymidylate kinase; Validated; Region: tmk; PRK00698 286636001010 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 286636001011 TMP-binding site; other site 286636001012 ATP-binding site [chemical binding]; other site 286636001013 DNA polymerase III subunit delta'; Validated; Region: PRK07276 286636001014 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 286636001015 PSP1 C-terminal conserved region; Region: PSP1; cl00770 286636001016 PSP1 C-terminal conserved region; Region: PSP1; cl00770 286636001017 TSC-22/dip/bun family; Region: TSC22; cl01853 286636001018 Predicted methyltransferases [General function prediction only]; Region: COG0313 286636001019 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 286636001020 CutC family; Region: CutC; cl01218 286636001021 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 286636001022 ArsC family; Region: ArsC; pfam03960 286636001023 putative ArsC-like catalytic residues; other site 286636001024 putative TRX-like catalytic residues [active] 286636001025 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 286636001026 active site 286636001027 DNA binding site [nucleotide binding] 286636001028 putative phosphate binding site [ion binding]; other site 286636001029 putative catalytic site [active] 286636001030 metal binding site A [ion binding]; metal-binding site 286636001031 AP binding site [nucleotide binding]; other site 286636001032 metal binding site B [ion binding]; metal-binding site 286636001033 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 286636001034 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 286636001035 teramer interface [polypeptide binding]; other site 286636001036 active site 286636001037 FMN binding site [chemical binding]; other site 286636001038 catalytic residues [active] 286636001039 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 286636001040 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 286636001041 putative active site [active] 286636001042 catalytic triad [active] 286636001043 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 286636001044 putative integrin binding motif; other site 286636001045 PA/protease domain interface [polypeptide binding]; other site 286636001046 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 286636001047 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 286636001048 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 286636001049 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 286636001050 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 286636001051 active site 286636001052 HIGH motif; other site 286636001053 KMSKS motif; other site 286636001054 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 286636001055 tRNA binding surface [nucleotide binding]; other site 286636001056 anticodon binding site; other site 286636001057 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 286636001058 dimer interface [polypeptide binding]; other site 286636001059 putative tRNA-binding site [nucleotide binding]; other site 286636001060 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 286636001061 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 286636001062 dimer interface [polypeptide binding]; other site 286636001063 putative radical transfer pathway; other site 286636001064 diiron center [ion binding]; other site 286636001065 tyrosyl radical; other site 286636001066 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 286636001067 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07187 286636001068 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 286636001069 Class I ribonucleotide reductase; Region: RNR_I; cd01679 286636001070 active site 286636001071 dimer interface [polypeptide binding]; other site 286636001072 catalytic residues [active] 286636001073 effector binding site; other site 286636001074 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 286636001075 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cd00233 286636001076 active site 286636001077 conformational flexibility of ligand binding pocket; other site 286636001078 ADP-ribosylating toxin turn-turn motif; other site 286636001079 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 286636001080 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 286636001081 classical (c) SDRs; Region: SDR_c; cd05233 286636001082 NAD(P) binding site [chemical binding]; other site 286636001083 active site 286636001084 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 286636001085 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636001086 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 286636001087 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 286636001088 putative substrate translocation pore; other site 286636001089 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 286636001090 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 286636001091 Substrate binding site; other site 286636001092 Mg++ binding site; other site 286636001093 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 286636001094 active site 286636001095 substrate binding site [chemical binding]; other site 286636001096 CoA binding site [chemical binding]; other site 286636001097 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 286636001098 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 286636001099 dimer interface [polypeptide binding]; other site 286636001100 ADP-ribose binding site [chemical binding]; other site 286636001101 active site 286636001102 nudix motif; other site 286636001103 metal binding site [ion binding]; metal-binding site 286636001104 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 286636001105 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 286636001106 Helix-turn-helix domains; Region: HTH; cl00088 286636001107 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 286636001108 FeoA domain; Region: FeoA; cl00838 286636001109 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 286636001110 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 286636001111 metal binding site [ion binding]; metal-binding site 286636001112 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 286636001113 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 286636001114 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 286636001115 ABC-ATPase subunit interface; other site 286636001116 dimer interface [polypeptide binding]; other site 286636001117 putative PBP binding regions; other site 286636001118 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 286636001119 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 286636001120 active site 286636001121 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 286636001122 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 286636001123 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 286636001124 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 286636001125 Transposase [DNA replication, recombination, and repair]; Region: COG5433 286636001126 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 286636001127 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 286636001128 23S rRNA interface [nucleotide binding]; other site 286636001129 L7/L12 interface [polypeptide binding]; other site 286636001130 putative thiostrepton binding site; other site 286636001131 L25 interface [polypeptide binding]; other site 286636001132 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 286636001133 mRNA/rRNA interface [nucleotide binding]; other site 286636001134 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 286636001135 Helix-turn-helix domains; Region: HTH; cl00088 286636001136 Integrase core domain; Region: rve; cl01316 286636001137 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 286636001138 putative nucleotide binding site [chemical binding]; other site 286636001139 uridine monophosphate binding site [chemical binding]; other site 286636001140 homohexameric interface [polypeptide binding]; other site 286636001141 ribosome recycling factor; Reviewed; Region: frr; PRK00083 286636001142 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 286636001143 hinge region; other site 286636001144 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 286636001145 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 286636001146 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 286636001147 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 286636001148 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 286636001149 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 286636001150 putative peptidoglycan binding site; other site 286636001151 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636001152 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 286636001153 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 286636001154 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 286636001155 putative uracil binding site [chemical binding]; other site 286636001156 putative active site [active] 286636001157 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 286636001158 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 286636001159 GTPase Era; Reviewed; Region: era; PRK00089 286636001160 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 286636001161 G1 box; other site 286636001162 GTP/Mg2+ binding site [chemical binding]; other site 286636001163 Switch I region; other site 286636001164 G2 box; other site 286636001165 Switch II region; other site 286636001166 G3 box; other site 286636001167 G4 box; other site 286636001168 G5 box; other site 286636001169 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 286636001170 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 286636001171 nudix motif; other site 286636001172 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 286636001173 Transposase, Mutator family; Region: Transposase_mut; pfam00872 286636001174 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 286636001175 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 286636001176 non-specific DNA binding site [nucleotide binding]; other site 286636001177 salt bridge; other site 286636001178 sequence-specific DNA binding site [nucleotide binding]; other site 286636001179 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 286636001180 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 286636001181 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 286636001182 DNA binding site [nucleotide binding] 286636001183 catalytic residue [active] 286636001184 H2TH interface [polypeptide binding]; other site 286636001185 putative catalytic residues [active] 286636001186 turnover-facilitating residue; other site 286636001187 intercalation triad [nucleotide binding]; other site 286636001188 8OG recognition residue [nucleotide binding]; other site 286636001189 putative reading head residues; other site 286636001190 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 286636001191 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 286636001192 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 286636001193 CoA-binding site [chemical binding]; other site 286636001194 Domain of unknown function DUF87; Region: DUF87; pfam01935 286636001195 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 286636001196 drug efflux system protein MdtG; Provisional; Region: PRK09874 286636001197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 286636001198 putative substrate translocation pore; other site 286636001199 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 286636001200 Preprotein translocase SecG subunit; Region: SecG; cl09123 286636001201 ribonuclease R; Region: RNase_R; TIGR02063 286636001202 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 286636001203 RNB domain; Region: RNB; pfam00773 286636001204 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 286636001205 RNA binding site [nucleotide binding]; other site 286636001206 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 286636001207 SmpB-tmRNA interface; other site 286636001208 Glutamine cyclotransferase; Region: Glu_cyclase_2; pfam05096 286636001209 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 286636001210 putative substrate binding pocket [chemical binding]; other site 286636001211 AC domain interface; other site 286636001212 catalytic triad [active] 286636001213 AB domain interface; other site 286636001214 interchain disulfide; other site 286636001215 Protein of unknown function (DUF979); Region: DUF979; cl01572 286636001216 Protein of unknown function (DUF969); Region: DUF969; cl01573 286636001217 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 286636001218 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 286636001219 Ligand binding site; other site 286636001220 Putative Catalytic site; other site 286636001221 DXD motif; other site 286636001222 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 286636001223 dimer interface [polypeptide binding]; other site 286636001224 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 286636001225 active site 286636001226 metal binding site [ion binding]; metal-binding site 286636001227 glutathione binding site [chemical binding]; other site 286636001228 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 286636001229 dimer interface [polypeptide binding]; other site 286636001230 FMN binding site [chemical binding]; other site 286636001231 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 286636001232 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 286636001233 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 286636001234 active site 286636001235 catabolite control protein A; Region: ccpA; TIGR01481 286636001236 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 286636001237 DNA binding site [nucleotide binding] 286636001238 domain linker motif; other site 286636001239 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 286636001240 dimerization interface [polypeptide binding]; other site 286636001241 effector binding site; other site 286636001242 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 286636001243 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 286636001244 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 286636001245 putative ADP-binding pocket [chemical binding]; other site 286636001246 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 286636001247 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 286636001248 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 286636001249 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 286636001250 active site 286636001251 dimer interface [polypeptide binding]; other site 286636001252 motif 1; other site 286636001253 motif 2; other site 286636001254 motif 3; other site 286636001255 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 286636001256 anticodon binding site; other site 286636001257 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 286636001258 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 286636001259 Walker A/P-loop; other site 286636001260 ATP binding site [chemical binding]; other site 286636001261 Q-loop/lid; other site 286636001262 ABC transporter signature motif; other site 286636001263 Walker B; other site 286636001264 D-loop; other site 286636001265 H-loop/switch region; other site 286636001266 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 286636001267 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 286636001268 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 286636001269 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 286636001270 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 286636001271 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 286636001272 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 286636001273 DAK2 domain; Region: Dak2; cl03685 286636001274 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 286636001275 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 286636001276 amphipathic channel; other site 286636001277 Asn-Pro-Ala signature motifs; other site 286636001278 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 286636001279 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 286636001280 dimer interface [polypeptide binding]; other site 286636001281 active site 286636001282 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 286636001283 AMP-binding enzyme; Region: AMP-binding; cl15778 286636001284 peptide synthase; Validated; Region: PRK05691 286636001285 Protein of unknown function (DUF3114); Region: DUF3114; pfam11311 286636001286 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 286636001287 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 286636001288 active site 286636001289 phosphorylation site [posttranslational modification] 286636001290 intermolecular recognition site; other site 286636001291 dimerization interface [polypeptide binding]; other site 286636001292 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 286636001293 DNA binding site [nucleotide binding] 286636001294 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 286636001295 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 286636001296 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 286636001297 dimer interface [polypeptide binding]; other site 286636001298 phosphorylation site [posttranslational modification] 286636001299 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 286636001300 ATP binding site [chemical binding]; other site 286636001301 Mg2+ binding site [ion binding]; other site 286636001302 G-X-G motif; other site 286636001303 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 286636001304 ribonuclease III; Reviewed; Region: rnc; PRK00102 286636001305 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 286636001306 dimerization interface [polypeptide binding]; other site 286636001307 active site 286636001308 metal binding site [ion binding]; metal-binding site 286636001309 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 286636001310 dsRNA binding site [nucleotide binding]; other site 286636001311 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 286636001312 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 286636001313 Walker A/P-loop; other site 286636001314 ATP binding site [chemical binding]; other site 286636001315 Q-loop/lid; other site 286636001316 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 286636001317 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 286636001318 ABC transporter signature motif; other site 286636001319 Walker B; other site 286636001320 D-loop; other site 286636001321 H-loop/switch region; other site 286636001322 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 286636001323 non-specific DNA binding site [nucleotide binding]; other site 286636001324 salt bridge; other site 286636001325 sequence-specific DNA binding site [nucleotide binding]; other site 286636001326 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 286636001327 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 286636001328 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 286636001329 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 286636001330 shikimate binding site; other site 286636001331 NAD(P) binding site [chemical binding]; other site 286636001332 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 286636001333 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 286636001334 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 286636001335 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 286636001336 Archaeal S-adenosylmethionine synthetase [Amino acid transport and metabolism]; Region: MetK; COG1812 286636001337 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 286636001338 active site 286636001339 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 286636001340 active site 286636001341 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 286636001342 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636001343 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 286636001344 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636001345 Ferroportin1 (FPN1); Region: FPN1; pfam06963 286636001346 H+ Antiporter protein; Region: 2A0121; TIGR00900 286636001347 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 286636001348 RelB antitoxin; Region: RelB; cl01171 286636001349 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 286636001350 Phage-related protein [Function unknown]; Region: COG4695; cl01923 286636001351 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 286636001352 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 286636001353 active site 286636001354 motif I; other site 286636001355 motif II; other site 286636001356 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 286636001357 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 286636001358 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 286636001359 active site 286636001360 motif I; other site 286636001361 motif II; other site 286636001362 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 286636001363 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 286636001364 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 286636001365 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 286636001366 P loop; other site 286636001367 GTP binding site [chemical binding]; other site 286636001368 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 286636001369 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 286636001370 putative substrate translocation pore; other site 286636001371 transcriptional antiterminator BglG; Provisional; Region: PRK09772 286636001372 CAT RNA binding domain; Region: CAT_RBD; cl03904 286636001373 PRD domain; Region: PRD; cl15445 286636001374 PRD domain; Region: PRD; cl15445 286636001375 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 286636001376 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 286636001377 active site turn [active] 286636001378 phosphorylation site [posttranslational modification] 286636001379 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 286636001380 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 286636001381 HPr interaction site; other site 286636001382 glycerol kinase (GK) interaction site [polypeptide binding]; other site 286636001383 active site 286636001384 phosphorylation site [posttranslational modification] 286636001385 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 286636001386 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 286636001387 Predicted permeases [General function prediction only]; Region: COG0701 286636001388 Predicted permease; Region: DUF318; pfam03773 286636001389 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 286636001390 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 286636001391 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 286636001392 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 286636001393 RNA binding site [nucleotide binding]; other site 286636001394 hypothetical protein; Provisional; Region: PRK04351 286636001395 SprT homologues; Region: SprT; cl01182 286636001396 PspC domain; Region: PspC; cl00864 286636001397 HPr kinase/phosphorylase; Provisional; Region: PRK05428 286636001398 DRTGG domain; Region: DRTGG; cl12147 286636001399 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 286636001400 Hpr binding site; other site 286636001401 active site 286636001402 homohexamer subunit interaction site [polypeptide binding]; other site 286636001403 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 286636001404 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 286636001405 YtxH-like protein; Region: YtxH; cl02079 286636001406 Protein of unknown function (DUF3270); Region: DUF3270; pfam11674 286636001407 coenzyme PQQ biosynthesis enzyme PqqE; Region: PQQ_syn_pqqE; TIGR02109 286636001408 Peptidase family U32; Region: Peptidase_U32; cl03113 286636001409 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 286636001410 Peptidase family U32; Region: Peptidase_U32; cl03113 286636001411 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; cl01839 286636001412 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 286636001413 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 286636001414 dimer interface [polypeptide binding]; other site 286636001415 putative anticodon binding site; other site 286636001416 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 286636001417 motif 1; other site 286636001418 active site 286636001419 motif 2; other site 286636001420 motif 3; other site 286636001421 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 286636001422 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 286636001423 motif II; other site 286636001424 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 286636001425 catalytic core [active] 286636001426 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 286636001427 putative deacylase active site [active] 286636001428 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 286636001429 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 286636001430 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 286636001431 active site 286636001432 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 286636001433 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 286636001434 catalytic residues [active] 286636001435 dimer interface [polypeptide binding]; other site 286636001436 oligoendopeptidase F; Region: pepF; TIGR00181 286636001437 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 286636001438 Zn binding site [ion binding]; other site 286636001439 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 286636001440 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 286636001441 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 286636001442 elongation factor Tu; Reviewed; Region: PRK00049 286636001443 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 286636001444 G1 box; other site 286636001445 GEF interaction site [polypeptide binding]; other site 286636001446 GTP/Mg2+ binding site [chemical binding]; other site 286636001447 Switch I region; other site 286636001448 G2 box; other site 286636001449 G3 box; other site 286636001450 Switch II region; other site 286636001451 G4 box; other site 286636001452 G5 box; other site 286636001453 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 286636001454 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 286636001455 Antibiotic Binding Site [chemical binding]; other site 286636001456 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 286636001457 substrate binding site [chemical binding]; other site 286636001458 dimer interface [polypeptide binding]; other site 286636001459 catalytic triad [active] 286636001460 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 286636001461 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 286636001462 sugar phosphate phosphatase; Provisional; Region: PRK10513 286636001463 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 286636001464 motif II; other site 286636001465 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 286636001466 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 286636001467 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 286636001468 Zn2+ binding site [ion binding]; other site 286636001469 Mg2+ binding site [ion binding]; other site 286636001470 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 286636001471 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 286636001472 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 286636001473 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 286636001474 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 286636001475 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 286636001476 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 286636001477 Transcriptional regulators [Transcription]; Region: PurR; COG1609 286636001478 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 286636001479 DNA binding site [nucleotide binding] 286636001480 domain linker motif; other site 286636001481 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 286636001482 putative dimerization interface [polypeptide binding]; other site 286636001483 putative ligand binding site [chemical binding]; other site 286636001484 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 286636001485 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 286636001486 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 286636001487 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 286636001488 active site 286636001489 phosphorylation site [posttranslational modification] 286636001490 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 286636001491 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 286636001492 active pocket/dimerization site; other site 286636001493 active site 286636001494 phosphorylation site [posttranslational modification] 286636001495 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 286636001496 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 286636001497 NADP binding site [chemical binding]; other site 286636001498 homodimer interface [polypeptide binding]; other site 286636001499 active site 286636001500 hypothetical protein; Provisional; Region: PRK09273 286636001501 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 286636001502 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 286636001503 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 286636001504 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 286636001505 substrate binding site [chemical binding]; other site 286636001506 ATP binding site [chemical binding]; other site 286636001507 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 286636001508 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 286636001509 active site 286636001510 intersubunit interface [polypeptide binding]; other site 286636001511 catalytic residue [active] 286636001512 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 286636001513 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 286636001514 motif II; other site 286636001515 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 286636001516 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 286636001517 peptide chain release factor 2; Validated; Region: prfB; PRK00578 286636001518 RF-1 domain; Region: RF-1; cl02875 286636001519 RF-1 domain; Region: RF-1; cl02875 286636001520 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 286636001521 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 286636001522 Walker A/P-loop; other site 286636001523 ATP binding site [chemical binding]; other site 286636001524 Q-loop/lid; other site 286636001525 ABC transporter signature motif; other site 286636001526 Walker B; other site 286636001527 D-loop; other site 286636001528 H-loop/switch region; other site 286636001529 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 286636001530 FtsX-like permease family; Region: FtsX; cl15850 286636001531 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 286636001532 acetoin reductase; Validated; Region: PRK08643 286636001533 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 286636001534 NAD binding site [chemical binding]; other site 286636001535 homotetramer interface [polypeptide binding]; other site 286636001536 homodimer interface [polypeptide binding]; other site 286636001537 active site 286636001538 substrate binding site [chemical binding]; other site 286636001539 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246 286636001540 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 286636001541 active site 286636001542 catalytic site [active] 286636001543 substrate binding site [chemical binding]; other site 286636001544 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 286636001545 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 286636001546 aspartate aminotransferase; Provisional; Region: PRK05764 286636001547 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 286636001548 pyridoxal 5'-phosphate binding site [chemical binding]; other site 286636001549 homodimer interface [polypeptide binding]; other site 286636001550 catalytic residue [active] 286636001551 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 286636001552 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 286636001553 putative dimer interface [polypeptide binding]; other site 286636001554 putative anticodon binding site; other site 286636001555 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 286636001556 homodimer interface [polypeptide binding]; other site 286636001557 motif 1; other site 286636001558 motif 2; other site 286636001559 active site 286636001560 motif 3; other site 286636001561 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 286636001562 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 286636001563 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 286636001564 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 286636001565 dimer interface [polypeptide binding]; other site 286636001566 phosphate binding site [ion binding]; other site 286636001567 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 286636001568 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 286636001569 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 286636001570 Peptidase family C69; Region: Peptidase_C69; pfam03577 286636001571 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 286636001572 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 286636001573 metal binding site [ion binding]; metal-binding site 286636001574 YodA lipocalin-like domain; Region: YodA; cl01365 286636001575 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 286636001576 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 286636001577 DNA-binding site [nucleotide binding]; DNA binding site 286636001578 UTRA domain; Region: UTRA; cl01230 286636001579 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 286636001580 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 286636001581 dimer interface [polypeptide binding]; other site 286636001582 active site 286636001583 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 286636001584 putative active site [active] 286636001585 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 286636001586 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 286636001587 DHH family; Region: DHH; pfam01368 286636001588 DHHA1 domain; Region: DHHA1; pfam02272 286636001589 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 286636001590 Chorismate mutase type II; Region: CM_2; cl00693 286636001591 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 286636001592 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 286636001593 Cl- selectivity filter; other site 286636001594 Cl- binding residues [ion binding]; other site 286636001595 pore gating glutamate residue; other site 286636001596 dimer interface [polypeptide binding]; other site 286636001597 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 286636001598 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 286636001599 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 286636001600 motif II; other site 286636001601 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 286636001602 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 286636001603 Mg2+ binding site [ion binding]; other site 286636001604 G-X-G motif; other site 286636001605 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 286636001606 anchoring element; other site 286636001607 dimer interface [polypeptide binding]; other site 286636001608 ATP binding site [chemical binding]; other site 286636001609 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 286636001610 active site 286636001611 putative metal-binding site [ion binding]; other site 286636001612 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 286636001613 septation ring formation regulator EzrA; Provisional; Region: PRK04778 286636001614 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 286636001615 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 286636001616 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 286636001617 Enolase, C-terminal TIM barrel domain; Region: Enolase_C; pfam00113 286636001618 substrate binding pocket [chemical binding]; other site 286636001619 dimer interface [polypeptide binding]; other site 286636001620 metal binding site [ion binding]; metal-binding site 286636001621 bacteriocin protoxin, streptolysin S family; Region: streptolysinS; TIGR03602 286636001622 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 286636001623 putative FMN binding site [chemical binding]; other site 286636001624 NADPH bind site [chemical binding]; other site 286636001625 bacteriocin biosynthesis cyclodehydratase, SagC family; Region: cyclo_dehy_ocin; TIGR03603 286636001626 Uncharacterized conserved protein [Function unknown]; Region: COG1944; cl09146 286636001627 YcaO-like family; Region: YcaO; pfam02624 286636001628 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 286636001629 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 286636001630 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 286636001631 Walker A/P-loop; other site 286636001632 ATP binding site [chemical binding]; other site 286636001633 Q-loop/lid; other site 286636001634 ABC transporter signature motif; other site 286636001635 Walker B; other site 286636001636 D-loop; other site 286636001637 H-loop/switch region; other site 286636001638 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 286636001639 ABC-2 type transporter; Region: ABC2_membrane; cl11417 286636001640 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 286636001641 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 286636001642 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 286636001643 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 286636001644 generic binding surface II; other site 286636001645 generic binding surface I; other site 286636001646 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 286636001647 generic binding surface II; other site 286636001648 generic binding surface I; other site 286636001649 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 286636001650 putative catalytic site [active] 286636001651 putative metal binding site [ion binding]; other site 286636001652 putative phosphate binding site [ion binding]; other site 286636001653 QueT transporter; Region: QueT; cl01932 286636001654 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 286636001655 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 286636001656 nucleotide binding pocket [chemical binding]; other site 286636001657 K-X-D-G motif; other site 286636001658 catalytic site [active] 286636001659 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 286636001660 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 286636001661 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 286636001662 Dimer interface [polypeptide binding]; other site 286636001663 BRCT sequence motif; other site 286636001664 putative lipid kinase; Reviewed; Region: PRK13055 286636001665 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 286636001666 ATP synthase subunit C; Region: ATP-synt_C; cl00466 286636001667 ATP synthase A chain; Region: ATP-synt_A; cl00413 286636001668 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 286636001669 Mitochondrial ATP synthase B chain precursor (ATP-synt_B); Region: Mt_ATP-synt_B; cl07975 286636001670 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl15360 286636001671 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 286636001672 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 286636001673 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 286636001674 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 286636001675 beta subunit interaction interface [polypeptide binding]; other site 286636001676 Walker A motif; other site 286636001677 ATP binding site [chemical binding]; other site 286636001678 Walker B motif; other site 286636001679 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 286636001680 ATP synthase; Region: ATP-synt; cl00365 286636001681 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 286636001682 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 286636001683 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 286636001684 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 286636001685 alpha subunit interaction interface [polypeptide binding]; other site 286636001686 Walker A motif; other site 286636001687 ATP binding site [chemical binding]; other site 286636001688 Walker B motif; other site 286636001689 inhibitor binding site; inhibition site 286636001690 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 286636001691 ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063 286636001692 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 286636001693 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 286636001694 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 286636001695 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 286636001696 hinge; other site 286636001697 active site 286636001698 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 286636001699 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 286636001700 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 286636001701 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 286636001702 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 286636001703 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 286636001704 dimer interface [polypeptide binding]; other site 286636001705 motif 1; other site 286636001706 active site 286636001707 motif 2; other site 286636001708 motif 3; other site 286636001709 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 286636001710 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 286636001711 putative tRNA-binding site [nucleotide binding]; other site 286636001712 B3/4 domain; Region: B3_4; cl11458 286636001713 tRNA synthetase B5 domain; Region: B5; cl08394 286636001714 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 286636001715 dimer interface [polypeptide binding]; other site 286636001716 motif 1; other site 286636001717 motif 3; other site 286636001718 motif 2; other site 286636001719 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 286636001720 OsmC-like protein; Region: OsmC; cl00767 286636001721 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 286636001722 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 286636001723 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 286636001724 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 286636001725 Walker A/P-loop; other site 286636001726 ATP binding site [chemical binding]; other site 286636001727 Q-loop/lid; other site 286636001728 ABC transporter signature motif; other site 286636001729 Walker B; other site 286636001730 D-loop; other site 286636001731 H-loop/switch region; other site 286636001732 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 286636001733 ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774 286636001734 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 286636001735 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 286636001736 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 286636001737 Family description; Region: UvrD_C_2; cl15862 286636001738 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 286636001739 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 286636001740 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 286636001741 substrate binding pocket [chemical binding]; other site 286636001742 membrane-bound complex binding site; other site 286636001743 hinge residues; other site 286636001744 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 286636001745 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 286636001746 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 286636001747 DNA primase; Validated; Region: dnaG; PRK05667 286636001748 CHC2 zinc finger; Region: zf-CHC2; cl15369 286636001749 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 286636001750 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 286636001751 active site 286636001752 metal binding site [ion binding]; metal-binding site 286636001753 interdomain interaction site; other site 286636001754 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 286636001755 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 286636001756 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 286636001757 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 286636001758 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 286636001759 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 286636001760 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 286636001761 DNA binding residues [nucleotide binding] 286636001762 Domain of unknown function DUF59; Region: DUF59; cl00941 286636001763 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 286636001764 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 286636001765 NADP binding site [chemical binding]; other site 286636001766 active site 286636001767 putative substrate binding site [chemical binding]; other site 286636001768 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 286636001769 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 286636001770 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 286636001771 Probable Catalytic site; other site 286636001772 ABC-2 type transporter; Region: ABC2_membrane; cl11417 286636001773 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 286636001774 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 286636001775 Walker A/P-loop; other site 286636001776 ATP binding site [chemical binding]; other site 286636001777 Q-loop/lid; other site 286636001778 ABC transporter signature motif; other site 286636001779 Walker B; other site 286636001780 D-loop; other site 286636001781 H-loop/switch region; other site 286636001782 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 286636001783 active site 286636001784 Rhamnan synthesis protein F; Region: RgpF; cl01529 286636001785 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 286636001786 Sulfatase; Region: Sulfatase; cl10460 286636001787 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 286636001788 Ligand binding site; other site 286636001789 Putative Catalytic site; other site 286636001790 DXD motif; other site 286636001791 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 286636001792 MatE; Region: MatE; cl10513 286636001793 Predicted membrane protein (DUF2142); Region: DUF2142; cl01937 286636001794 peptidase T; Region: peptidase-T; TIGR01882 286636001795 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 286636001796 metal binding site [ion binding]; metal-binding site 286636001797 dimer interface [polypeptide binding]; other site 286636001798 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 286636001799 cytidylate kinase; Provisional; Region: cmk; PRK00023 286636001800 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 286636001801 CMP-binding site; other site 286636001802 The sites determining sugar specificity; other site 286636001803 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 286636001804 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 286636001805 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 286636001806 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 286636001807 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 286636001808 23S rRNA binding site [nucleotide binding]; other site 286636001809 L21 binding site [polypeptide binding]; other site 286636001810 L13 binding site [polypeptide binding]; other site 286636001811 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 286636001812 Sulfatase; Region: Sulfatase; cl10460 286636001813 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 286636001814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 286636001815 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 286636001816 3-dehydroquinate dehydratase, type I; Region: aroD; TIGR01093 286636001817 active site 286636001818 catalytic residue [active] 286636001819 dimer interface [polypeptide binding]; other site 286636001820 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 286636001821 Tetramer interface [polypeptide binding]; other site 286636001822 active site 286636001823 FMN-binding site [chemical binding]; other site 286636001824 Protein of unknown function (DUF964); Region: DUF964; cl01483 286636001825 glutathione reductase; Validated; Region: PRK06116 286636001826 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 286636001827 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 286636001828 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 286636001829 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 286636001830 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 286636001831 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 286636001832 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 286636001833 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 286636001834 catalytic residue [active] 286636001835 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 286636001836 THUMP domain; Region: THUMP; cl12076 286636001837 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 286636001838 Ligand Binding Site [chemical binding]; other site 286636001839 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 286636001840 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 286636001841 putative active site [active] 286636001842 putative metal binding site [ion binding]; other site 286636001843 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 286636001844 Helix-turn-helix domains; Region: HTH; cl00088 286636001845 Integrase core domain; Region: rve; cl01316 286636001846 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 286636001847 Protein of unknown function (DUF464); Region: DUF464; cl01080 286636001848 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 286636001849 Transcriptional regulator [Transcription]; Region: LysR; COG0583 286636001850 Helix-turn-helix domains; Region: HTH; cl00088 286636001851 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 286636001852 dimerization interface [polypeptide binding]; other site 286636001853 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 286636001854 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 286636001855 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 286636001856 RNA binding surface [nucleotide binding]; other site 286636001857 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 286636001858 active site 286636001859 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 286636001860 active site 286636001861 uracil transporter; Provisional; Region: PRK10720 286636001862 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 286636001863 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 286636001864 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 286636001865 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636001866 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 286636001867 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 286636001868 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 286636001869 catalytic site [active] 286636001870 subunit interface [polypeptide binding]; other site 286636001871 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 286636001872 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 286636001873 ATP-grasp domain; Region: ATP-grasp_4; cl03087 286636001874 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 286636001875 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 286636001876 ATP-grasp domain; Region: ATP-grasp_4; cl03087 286636001877 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 286636001878 IMP binding site; other site 286636001879 dimer interface [polypeptide binding]; other site 286636001880 interdomain contacts; other site 286636001881 partial ornithine binding site; other site 286636001882 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 286636001883 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 286636001884 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 286636001885 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 286636001886 Walker A/P-loop; other site 286636001887 ATP binding site [chemical binding]; other site 286636001888 Q-loop/lid; other site 286636001889 ABC transporter signature motif; other site 286636001890 Walker B; other site 286636001891 D-loop; other site 286636001892 H-loop/switch region; other site 286636001893 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 286636001894 FtsX-like permease family; Region: FtsX; cl15850 286636001895 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 286636001896 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 286636001897 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 286636001898 putative active site [active] 286636001899 catalytic site [active] 286636001900 putative metal binding site [ion binding]; other site 286636001901 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 286636001902 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 286636001903 hypothetical protein; Provisional; Region: PRK00468; cl00794 286636001904 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 286636001905 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 286636001906 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 286636001907 Cation efflux family; Region: Cation_efflux; cl00316 286636001908 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 286636001909 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 286636001910 RimM N-terminal domain; Region: RimM; pfam01782 286636001911 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 286636001912 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 286636001913 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 286636001914 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636001915 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636001916 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 286636001917 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 286636001918 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 286636001919 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636001920 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 286636001921 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 286636001922 Helix-turn-helix domains; Region: HTH; cl00088 286636001923 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 286636001924 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 286636001925 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 286636001926 putative substrate binding site [chemical binding]; other site 286636001927 putative ATP binding site [chemical binding]; other site 286636001928 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 286636001929 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 286636001930 active site 286636001931 phosphorylation site [posttranslational modification] 286636001932 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 286636001933 P-loop; other site 286636001934 active site 286636001935 phosphorylation site [posttranslational modification] 286636001936 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 286636001937 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 286636001938 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 286636001939 Integrase core domain; Region: rve; cl01316 286636001940 Integrase core domain; Region: rve_3; cl15866 286636001941 Mac 1; Region: Mac-1; pfam09028 286636001942 Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are...; Region: NDPk; cl00335 286636001943 multimer interface [polypeptide binding]; other site 286636001944 Protein of unknown function (DUF1149); Region: DUF1149; cl11551 286636001945 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 286636001946 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 286636001947 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 286636001948 active site 286636001949 NTP binding site [chemical binding]; other site 286636001950 metal binding triad [ion binding]; metal-binding site 286636001951 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 286636001952 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 286636001953 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 286636001954 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 286636001955 Walker A/P-loop; other site 286636001956 ATP binding site [chemical binding]; other site 286636001957 Q-loop/lid; other site 286636001958 ABC transporter signature motif; other site 286636001959 Walker B; other site 286636001960 D-loop; other site 286636001961 H-loop/switch region; other site 286636001962 ABC transporter; Region: ABC_tran_2; pfam12848 286636001963 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 286636001964 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636001965 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 286636001966 active site 286636001967 catalytic residues [active] 286636001968 metal binding site [ion binding]; metal-binding site 286636001969 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 286636001970 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 286636001971 putative active site [active] 286636001972 putative metal binding site [ion binding]; other site 286636001973 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 286636001974 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 286636001975 synthetase active site [active] 286636001976 NTP binding site [chemical binding]; other site 286636001977 metal binding site [ion binding]; metal-binding site 286636001978 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 286636001979 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 286636001980 active site 286636001981 phosphorylation site [posttranslational modification] 286636001982 intermolecular recognition site; other site 286636001983 dimerization interface [polypeptide binding]; other site 286636001984 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 286636001985 DNA binding site [nucleotide binding] 286636001986 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 286636001987 dimer interface [polypeptide binding]; other site 286636001988 phosphorylation site [posttranslational modification] 286636001989 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 286636001990 ATP binding site [chemical binding]; other site 286636001991 Mg2+ binding site [ion binding]; other site 286636001992 G-X-G motif; other site 286636001993 mevalonate kinase; Region: mevalon_kin; TIGR00549 286636001994 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 286636001995 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 286636001996 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 286636001997 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 286636001998 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 286636001999 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 286636002000 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 286636002001 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 286636002002 homotetramer interface [polypeptide binding]; other site 286636002003 FMN binding site [chemical binding]; other site 286636002004 homodimer contacts [polypeptide binding]; other site 286636002005 putative active site [active] 286636002006 putative substrate binding site [chemical binding]; other site 286636002007 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 286636002008 homodimer interface [polypeptide binding]; other site 286636002009 NAD binding site [chemical binding]; other site 286636002010 catalytic residues [active] 286636002011 substrate binding pocket [chemical binding]; other site 286636002012 flexible flap; other site 286636002013 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...; Region: init_cond_enzymes; cd00827 286636002014 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 286636002015 dimer interface [polypeptide binding]; other site 286636002016 active site 286636002017 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 286636002018 dimerization interface [polypeptide binding]; other site 286636002019 active site 286636002020 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 286636002021 folate binding site [chemical binding]; other site 286636002022 NADP+ binding site [chemical binding]; other site 286636002023 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 286636002024 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 286636002025 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 286636002026 Walker A motif; other site 286636002027 ATP binding site [chemical binding]; other site 286636002028 Walker B motif; other site 286636002029 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 286636002030 Predicted GTPase [General function prediction only]; Region: COG0218 286636002031 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 286636002032 G1 box; other site 286636002033 GTP/Mg2+ binding site [chemical binding]; other site 286636002034 Switch I region; other site 286636002035 G2 box; other site 286636002036 G3 box; other site 286636002037 Switch II region; other site 286636002038 G4 box; other site 286636002039 G5 box; other site 286636002040 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 286636002041 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 286636002042 Walker A motif; other site 286636002043 ATP binding site [chemical binding]; other site 286636002044 Walker B motif; other site 286636002045 arginine finger; other site 286636002046 UvrB/uvrC motif; Region: UVR; pfam02151 286636002047 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 286636002048 Walker A motif; other site 286636002049 ATP binding site [chemical binding]; other site 286636002050 Walker B motif; other site 286636002051 arginine finger; other site 286636002052 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 286636002053 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 286636002054 tetramer (dimer of dimers) interface [polypeptide binding]; other site 286636002055 active site 286636002056 dimer interface [polypeptide binding]; other site 286636002057 Sulfatase; Region: Sulfatase; cl10460 286636002058 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 286636002059 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 286636002060 ArsC family; Region: ArsC; pfam03960 286636002061 catalytic residues [active] 286636002062 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 286636002063 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 286636002064 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 286636002065 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873 286636002066 Transcriptional regulator [Transcription]; Region: LysR; COG0583 286636002067 Helix-turn-helix domains; Region: HTH; cl00088 286636002068 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 286636002069 dimerization interface [polypeptide binding]; other site 286636002070 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 286636002071 active site 286636002072 dimer interface [polypeptide binding]; other site 286636002073 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 286636002074 amidase; Provisional; Region: PRK06529 286636002075 Amidase; Region: Amidase; cl11426 286636002076 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 286636002077 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 286636002078 substrate binding pocket [chemical binding]; other site 286636002079 membrane-bound complex binding site; other site 286636002080 hinge residues; other site 286636002081 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 286636002082 dimer interface [polypeptide binding]; other site 286636002083 conserved gate region; other site 286636002084 putative PBP binding loops; other site 286636002085 ABC-ATPase subunit interface; other site 286636002086 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 286636002087 ligand binding site [chemical binding]; other site 286636002088 active site 286636002089 UGI interface [polypeptide binding]; other site 286636002090 catalytic site [active] 286636002091 dihydroorotase; Validated; Region: pyrC; PRK09357 286636002092 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 286636002093 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 286636002094 active site 286636002095 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 286636002096 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 286636002097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 286636002098 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 286636002099 anchoring element; other site 286636002100 dimer interface [polypeptide binding]; other site 286636002101 ATP binding site [chemical binding]; other site 286636002102 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 286636002103 active site 286636002104 putative metal-binding site [ion binding]; other site 286636002105 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 286636002106 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 286636002107 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 286636002108 CAP-like domain; other site 286636002109 active site 286636002110 primary dimer interface [polypeptide binding]; other site 286636002111 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 286636002112 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 286636002113 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 286636002114 homodimer interface [polypeptide binding]; other site 286636002115 substrate-cofactor binding pocket; other site 286636002116 catalytic residue [active] 286636002117 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 286636002118 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 286636002119 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 286636002120 RNA binding site [nucleotide binding]; other site 286636002121 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 286636002122 RNA binding site [nucleotide binding]; other site 286636002123 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 286636002124 RNA binding site [nucleotide binding]; other site 286636002125 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 286636002126 RNA binding site [nucleotide binding]; other site 286636002127 Helix-turn-helix domains; Region: HTH; cl00088 286636002128 putative transposase OrfB; Reviewed; Region: PHA02517 286636002129 HTH-like domain; Region: HTH_21; pfam13276 286636002130 Integrase core domain; Region: rve; cl01316 286636002131 Integrase core domain; Region: rve_3; cl15866 286636002132 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 286636002133 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 286636002134 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 286636002135 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 286636002136 non-specific DNA binding site [nucleotide binding]; other site 286636002137 salt bridge; other site 286636002138 sequence-specific DNA binding site [nucleotide binding]; other site 286636002139 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 286636002140 Catalytic site [active] 286636002141 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 286636002142 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 286636002143 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 286636002144 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 286636002145 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 286636002146 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 286636002147 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 286636002148 active site residue [active] 286636002149 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 286636002150 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 286636002151 dimer interface [polypeptide binding]; other site 286636002152 N-terminal domain interface [polypeptide binding]; other site 286636002153 substrate binding pocket (H-site) [chemical binding]; other site 286636002154 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 286636002155 gating phenylalanine in ion channel; other site 286636002156 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 286636002157 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 286636002158 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 286636002159 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 286636002160 HflX GTPase family; Region: HflX; cd01878 286636002161 G1 box; other site 286636002162 GTP/Mg2+ binding site [chemical binding]; other site 286636002163 Switch I region; other site 286636002164 G2 box; other site 286636002165 G3 box; other site 286636002166 Switch II region; other site 286636002167 G4 box; other site 286636002168 G5 box; other site 286636002169 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 286636002170 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 286636002171 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 286636002172 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636002173 NAD(P) binding site [chemical binding]; other site 286636002174 active site 286636002175 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 286636002176 DHH family; Region: DHH; pfam01368 286636002177 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 286636002178 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 286636002179 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 286636002180 active site 286636002181 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 286636002182 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 286636002183 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 286636002184 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 286636002185 minor groove reading motif; other site 286636002186 helix-hairpin-helix signature motif; other site 286636002187 substrate binding pocket [chemical binding]; other site 286636002188 active site 286636002189 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 286636002190 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636002191 Uncharacterized conserved protein [Function unknown]; Region: COG0327 286636002192 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 286636002193 FAD dependent oxidoreductase; Region: DAO; pfam01266 286636002194 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636002195 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 286636002196 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 286636002197 substrate binding site; other site 286636002198 tetramer interface; other site 286636002199 Cupin domain; Region: Cupin_2; cl09118 286636002200 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 286636002201 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 286636002202 NAD binding site [chemical binding]; other site 286636002203 substrate binding site [chemical binding]; other site 286636002204 homodimer interface [polypeptide binding]; other site 286636002205 active site 286636002206 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 286636002207 putative active site [active] 286636002208 nucleotide binding site [chemical binding]; other site 286636002209 nudix motif; other site 286636002210 putative metal binding site [ion binding]; other site 286636002211 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 286636002212 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 286636002213 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 286636002214 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 286636002215 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 286636002216 Domain of unknown function (DUF814); Region: DUF814; pfam05670 286636002217 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 286636002218 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 286636002219 zinc binding site [ion binding]; other site 286636002220 putative ligand binding site [chemical binding]; other site 286636002221 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 286636002222 TM-ABC transporter signature motif; other site 286636002223 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 286636002224 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 286636002225 Walker A/P-loop; other site 286636002226 ATP binding site [chemical binding]; other site 286636002227 Q-loop/lid; other site 286636002228 ABC transporter signature motif; other site 286636002229 Walker B; other site 286636002230 D-loop; other site 286636002231 H-loop/switch region; other site 286636002232 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 286636002233 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 286636002234 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 286636002235 Predicted esterase [General function prediction only]; Region: COG0627 286636002236 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 286636002237 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 286636002238 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 286636002239 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 286636002240 ABC transporter; Region: ABC_tran_2; pfam12848 286636002241 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 286636002242 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 286636002243 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 286636002244 tetramer interface [polypeptide binding]; other site 286636002245 TPP-binding site [chemical binding]; other site 286636002246 heterodimer interface [polypeptide binding]; other site 286636002247 phosphorylation loop region [posttranslational modification] 286636002248 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 286636002249 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 286636002250 alpha subunit interface [polypeptide binding]; other site 286636002251 TPP binding site [chemical binding]; other site 286636002252 heterodimer interface [polypeptide binding]; other site 286636002253 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 286636002254 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 286636002255 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 286636002256 E3 interaction surface; other site 286636002257 lipoyl attachment site [posttranslational modification]; other site 286636002258 e3 binding domain; Region: E3_binding; pfam02817 286636002259 e3 binding domain; Region: E3_binding; pfam02817 286636002260 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 286636002261 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 286636002262 E3 interaction surface; other site 286636002263 lipoyl attachment site [posttranslational modification]; other site 286636002264 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 286636002265 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 286636002266 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 286636002267 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 286636002268 substrate binding site [chemical binding]; other site 286636002269 catalytic residues [active] 286636002270 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 286636002271 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 286636002272 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 286636002273 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 286636002274 catalytic triad [active] 286636002275 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 286636002276 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 286636002277 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 286636002278 Uncharacterized conserved protein [Function unknown]; Region: COG1624 286636002279 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 286636002280 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 286636002281 YbbR-like protein; Region: YbbR; pfam07949 286636002282 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 286636002283 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 286636002284 active site 286636002285 substrate binding site [chemical binding]; other site 286636002286 metal binding site [ion binding]; metal-binding site 286636002287 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 286636002288 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 286636002289 FeS/SAM binding site; other site 286636002290 HemN C-terminal domain; Region: HemN_C; pfam06969 286636002291 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 286636002292 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 286636002293 active site 286636002294 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 286636002295 active site 2 [active] 286636002296 active site 1 [active] 286636002297 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 286636002298 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 286636002299 active site 286636002300 motif I; other site 286636002301 motif II; other site 286636002302 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 286636002303 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 286636002304 Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are...; Region: NDPk; cl00335 286636002305 active site 286636002306 GTP-binding protein LepA; Provisional; Region: PRK05433 286636002307 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 286636002308 G1 box; other site 286636002309 putative GEF interaction site [polypeptide binding]; other site 286636002310 GTP/Mg2+ binding site [chemical binding]; other site 286636002311 Switch I region; other site 286636002312 G2 box; other site 286636002313 G3 box; other site 286636002314 Switch II region; other site 286636002315 G4 box; other site 286636002316 G5 box; other site 286636002317 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 286636002318 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 286636002319 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 286636002320 Gram positive anchor; Region: Gram_pos_anchor; cl15427 286636002321 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 286636002322 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 286636002323 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 286636002324 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 286636002325 active pocket/dimerization site; other site 286636002326 active site 286636002327 phosphorylation site [posttranslational modification] 286636002328 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 286636002329 active site 286636002330 phosphorylation site [posttranslational modification] 286636002331 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 286636002332 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 286636002333 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 286636002334 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 286636002335 Histidine kinase; Region: His_kinase; pfam06580 286636002336 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 286636002337 ATP binding site [chemical binding]; other site 286636002338 Mg2+ binding site [ion binding]; other site 286636002339 G-X-G motif; other site 286636002340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 286636002341 Response regulator receiver domain; Region: Response_reg; pfam00072 286636002342 active site 286636002343 phosphorylation site [posttranslational modification] 286636002344 intermolecular recognition site; other site 286636002345 dimerization interface [polypeptide binding]; other site 286636002346 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 286636002347 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 286636002348 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 286636002349 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 286636002350 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 286636002351 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 286636002352 NAD(P) binding site [chemical binding]; other site 286636002353 catalytic residues [active] 286636002354 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 286636002355 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 286636002356 GIY-YIG motif/motif A; other site 286636002357 active site 286636002358 catalytic site [active] 286636002359 putative DNA binding site [nucleotide binding]; other site 286636002360 metal binding site [ion binding]; metal-binding site 286636002361 UvrB/uvrC motif; Region: UVR; pfam02151 286636002362 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 286636002363 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 286636002364 dimer interface [polypeptide binding]; other site 286636002365 FMN binding site [chemical binding]; other site 286636002366 dipeptidase PepV; Reviewed; Region: PRK07318 286636002367 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 286636002368 active site 286636002369 metal binding site [ion binding]; metal-binding site 286636002370 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 286636002371 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 286636002372 trmE is a tRNA modification GTPase; Region: trmE; cd04164 286636002373 G1 box; other site 286636002374 GTP/Mg2+ binding site [chemical binding]; other site 286636002375 Switch I region; other site 286636002376 G2 box; other site 286636002377 Switch II region; other site 286636002378 G3 box; other site 286636002379 G4 box; other site 286636002380 G5 box; other site 286636002381 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 286636002382 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 286636002383 Helix-turn-helix domains; Region: HTH; cl00088 286636002384 Integrase core domain; Region: rve; cl01316 286636002385 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 286636002386 23S rRNA interface [nucleotide binding]; other site 286636002387 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 286636002388 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 286636002389 core dimer interface [polypeptide binding]; other site 286636002390 L10 interface [polypeptide binding]; other site 286636002391 L11 interface [polypeptide binding]; other site 286636002392 putative EF-Tu interaction site [polypeptide binding]; other site 286636002393 putative EF-G interaction site [polypeptide binding]; other site 286636002394 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 286636002395 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 286636002396 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 286636002397 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 286636002398 putative active site [active] 286636002399 putative metal binding site [ion binding]; other site 286636002400 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 286636002401 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 286636002402 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 286636002403 homodecamer interface [polypeptide binding]; other site 286636002404 GTP cyclohydrolase I; Provisional; Region: PLN03044 286636002405 active site 286636002406 putative catalytic site residues [active] 286636002407 zinc binding site [ion binding]; other site 286636002408 GTP-CH-I/GFRP interaction surface; other site 286636002409 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 286636002410 dihydropteroate synthase; Region: DHPS; TIGR01496 286636002411 substrate binding pocket [chemical binding]; other site 286636002412 dimer interface [polypeptide binding]; other site 286636002413 inhibitor binding site; inhibition site 286636002414 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 286636002415 homooctamer interface [polypeptide binding]; other site 286636002416 active site 286636002417 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 286636002418 catalytic center binding site [active] 286636002419 ATP binding site [chemical binding]; other site 286636002420 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 286636002421 FAD binding domain; Region: FAD_binding_4; pfam01565 286636002422 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 286636002423 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 286636002424 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300 286636002425 Walker A/P-loop; other site 286636002426 ATP binding site [chemical binding]; other site 286636002427 Q-loop/lid; other site 286636002428 ABC transporter signature motif; other site 286636002429 Walker B; other site 286636002430 D-loop; other site 286636002431 H-loop/switch region; other site 286636002432 TOBE domain; Region: TOBE_2; cl01440 286636002433 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 286636002434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 286636002435 dimer interface [polypeptide binding]; other site 286636002436 conserved gate region; other site 286636002437 putative PBP binding loops; other site 286636002438 ABC-ATPase subunit interface; other site 286636002439 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 286636002440 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 286636002441 dimer interface [polypeptide binding]; other site 286636002442 conserved gate region; other site 286636002443 putative PBP binding loops; other site 286636002444 ABC-ATPase subunit interface; other site 286636002445 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 286636002446 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 286636002447 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 286636002448 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 286636002449 active site 286636002450 phosphorylation site [posttranslational modification] 286636002451 intermolecular recognition site; other site 286636002452 dimerization interface [polypeptide binding]; other site 286636002453 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 286636002454 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 286636002455 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 286636002456 Malic enzyme, N-terminal domain; Region: malic; pfam00390 286636002457 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 286636002458 putative NAD(P) binding site [chemical binding]; other site 286636002459 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636002460 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 286636002461 catalytic Zn binding site [ion binding]; other site 286636002462 structural Zn binding site [ion binding]; other site 286636002463 NAD(P) binding site [chemical binding]; other site 286636002464 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 286636002465 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 286636002466 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 286636002467 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 286636002468 Cl- selectivity filter; other site 286636002469 Cl- binding residues [ion binding]; other site 286636002470 pore gating glutamate residue; other site 286636002471 dimer interface [polypeptide binding]; other site 286636002472 H+/Cl- coupling transport residue; other site 286636002473 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 286636002474 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 286636002475 active site 286636002476 catalytic triad [active] 286636002477 oxyanion hole [active] 286636002478 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 286636002479 Domain of unknown function DUF20; Region: UPF0118; cl00465 286636002480 hypothetical protein; Reviewed; Region: PRK00024 286636002481 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 286636002482 MPN+ (JAMM) motif; other site 286636002483 Zinc-binding site [ion binding]; other site 286636002484 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 286636002485 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 286636002486 catalytic triad [active] 286636002487 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 286636002488 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 286636002489 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636002490 Domain of unknown function (DUF1831); Region: DUF1831; pfam08866 286636002491 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 286636002492 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 286636002493 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 286636002494 catalytic residue [active] 286636002495 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 286636002496 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 286636002497 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 286636002498 active site 286636002499 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 286636002500 putative active site [active] 286636002501 putative metal binding residues [ion binding]; other site 286636002502 signature motif; other site 286636002503 putative triphosphate binding site [ion binding]; other site 286636002504 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 286636002505 synthetase active site [active] 286636002506 NTP binding site [chemical binding]; other site 286636002507 metal binding site [ion binding]; metal-binding site 286636002508 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 286636002509 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 286636002510 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 286636002511 active site 286636002512 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 286636002513 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 286636002514 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 286636002515 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636002516 NAD(P) binding site [chemical binding]; other site 286636002517 active site 286636002518 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 286636002519 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 286636002520 Walker A/P-loop; other site 286636002521 ATP binding site [chemical binding]; other site 286636002522 Q-loop/lid; other site 286636002523 ABC transporter signature motif; other site 286636002524 Walker B; other site 286636002525 D-loop; other site 286636002526 H-loop/switch region; other site 286636002527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 286636002528 dimer interface [polypeptide binding]; other site 286636002529 conserved gate region; other site 286636002530 ABC-ATPase subunit interface; other site 286636002531 NMT1-like family; Region: NMT1_2; cl15260 286636002532 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 286636002533 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 286636002534 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 286636002535 active site 286636002536 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 286636002537 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 286636002538 xanthine permease; Region: pbuX; TIGR03173 286636002539 ApbE family; Region: ApbE; cl00643 286636002540 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 286636002541 active site 1 [active] 286636002542 dimer interface [polypeptide binding]; other site 286636002543 hexamer interface [polypeptide binding]; other site 286636002544 active site 2 [active] 286636002545 thymidine kinase; Provisional; Region: PRK04296 286636002546 peptide chain release factor 1; Validated; Region: prfA; PRK00591 286636002547 RF-1 domain; Region: RF-1; cl02875 286636002548 RF-1 domain; Region: RF-1; cl02875 286636002549 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 286636002550 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 286636002551 S-adenosylmethionine binding site [chemical binding]; other site 286636002552 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 286636002553 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 286636002554 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 286636002555 Coenzyme A binding pocket [chemical binding]; other site 286636002556 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 286636002557 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 286636002558 dimer interface [polypeptide binding]; other site 286636002559 glycine-pyridoxal phosphate binding site [chemical binding]; other site 286636002560 active site 286636002561 folate binding site [chemical binding]; other site 286636002562 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 286636002563 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 286636002564 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 286636002565 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 286636002566 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 286636002567 Walker A/P-loop; other site 286636002568 ATP binding site [chemical binding]; other site 286636002569 Q-loop/lid; other site 286636002570 ABC transporter signature motif; other site 286636002571 Walker B; other site 286636002572 D-loop; other site 286636002573 H-loop/switch region; other site 286636002574 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 286636002575 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 286636002576 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 286636002577 Walker A/P-loop; other site 286636002578 ATP binding site [chemical binding]; other site 286636002579 Q-loop/lid; other site 286636002580 ABC transporter signature motif; other site 286636002581 Walker B; other site 286636002582 D-loop; other site 286636002583 H-loop/switch region; other site 286636002584 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 286636002585 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 286636002586 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 286636002587 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 286636002588 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 286636002589 tetramer (dimer of dimers) interface [polypeptide binding]; other site 286636002590 NAD binding site [chemical binding]; other site 286636002591 dimer interface [polypeptide binding]; other site 286636002592 substrate binding site [chemical binding]; other site 286636002593 DNA gyrase subunit A; Validated; Region: PRK05560 286636002594 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 286636002595 CAP-like domain; other site 286636002596 active site 286636002597 primary dimer interface [polypeptide binding]; other site 286636002598 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 286636002599 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 286636002600 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 286636002601 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 286636002602 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 286636002603 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 286636002604 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 286636002605 active site 286636002606 catalytic site [active] 286636002607 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 286636002608 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 286636002609 putative metal binding site [ion binding]; other site 286636002610 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 286636002611 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 286636002612 Haemolysin-III related; Region: HlyIII; cl03831 286636002613 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 286636002614 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 286636002615 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 286636002616 GTP/Mg2+ binding site [chemical binding]; other site 286636002617 G4 box; other site 286636002618 G5 box; other site 286636002619 G1 box; other site 286636002620 Switch I region; other site 286636002621 G2 box; other site 286636002622 G3 box; other site 286636002623 Switch II region; other site 286636002624 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 286636002625 RNA/DNA hybrid binding site [nucleotide binding]; other site 286636002626 active site 286636002627 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 286636002628 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 286636002629 DNA topoisomerase I; Validated; Region: PRK05582 286636002630 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 286636002631 active site 286636002632 interdomain interaction site; other site 286636002633 putative metal-binding site [ion binding]; other site 286636002634 nucleotide binding site [chemical binding]; other site 286636002635 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 286636002636 domain I; other site 286636002637 DNA binding groove [nucleotide binding] 286636002638 phosphate binding site [ion binding]; other site 286636002639 domain II; other site 286636002640 domain III; other site 286636002641 nucleotide binding site [chemical binding]; other site 286636002642 catalytic site [active] 286636002643 domain IV; other site 286636002644 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 286636002645 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 286636002646 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 286636002647 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636002648 oxaloacetate decarboxylase; Provisional; Region: PRK12581 286636002649 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 286636002650 active site 286636002651 catalytic residues [active] 286636002652 metal binding site [ion binding]; metal-binding site 286636002653 homodimer binding site [polypeptide binding]; other site 286636002654 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549 286636002655 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 286636002656 carboxyltransferase (CT) interaction site; other site 286636002657 biotinylation site [posttranslational modification]; other site 286636002658 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 286636002659 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 286636002660 Transcriptional regulators [Transcription]; Region: GntR; COG1802 286636002661 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 286636002662 DNA-binding site [nucleotide binding]; DNA binding site 286636002663 FCD domain; Region: FCD; cl11656 286636002664 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 286636002665 Citrate transporter; Region: CitMHS; pfam03600 286636002666 putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK05641 286636002667 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 286636002668 carboxyltransferase (CT) interaction site; other site 286636002669 biotinylation site [posttranslational modification]; other site 286636002670 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 286636002671 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 286636002672 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 286636002673 Citrate lyase, alpha subunit (CitF); Region: CitF; pfam04223 286636002674 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 286636002675 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498 286636002676 oxaloacetate decarboxylase; Provisional; Region: PRK12331 286636002677 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 286636002678 active site 286636002679 catalytic residues [active] 286636002680 metal binding site [ion binding]; metal-binding site 286636002681 homodimer binding site [polypeptide binding]; other site 286636002682 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 286636002683 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 286636002684 putative active site [active] 286636002685 (T/H)XGH motif; other site 286636002686 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 286636002687 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 286636002688 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 286636002689 DNA binding site [nucleotide binding] 286636002690 Int/Topo IB signature motif; other site 286636002691 active site 286636002692 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 286636002693 non-specific DNA binding site [nucleotide binding]; other site 286636002694 salt bridge; other site 286636002695 sequence-specific DNA binding site [nucleotide binding]; other site 286636002696 Predicted transcriptional regulator [Transcription]; Region: COG2932 286636002697 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 286636002698 Catalytic site [active] 286636002699 signal recognition particle protein; Provisional; Region: PRK10867 286636002700 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 286636002701 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 286636002702 P loop; other site 286636002703 GTP binding site [chemical binding]; other site 286636002704 Signal peptide binding domain; Region: SRP_SPB; pfam02978 286636002705 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 286636002706 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 286636002707 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 286636002708 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 286636002709 DNA-binding site [nucleotide binding]; DNA binding site 286636002710 UTRA domain; Region: UTRA; cl01230 286636002711 GMP synthase; Reviewed; Region: guaA; PRK00074 286636002712 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 286636002713 AMP/PPi binding site [chemical binding]; other site 286636002714 candidate oxyanion hole; other site 286636002715 catalytic triad [active] 286636002716 potential glutamine specificity residues [chemical binding]; other site 286636002717 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 286636002718 ATP Binding subdomain [chemical binding]; other site 286636002719 Dimerization subdomain; other site 286636002720 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 286636002721 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 286636002722 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 286636002723 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 286636002724 ABC transporter; Region: ABC_tran_2; pfam12848 286636002725 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 286636002726 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 286636002727 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 286636002728 dimer interface [polypeptide binding]; other site 286636002729 pyridoxal binding site [chemical binding]; other site 286636002730 ATP binding site [chemical binding]; other site 286636002731 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 286636002732 DNA-binding site [nucleotide binding]; DNA binding site 286636002733 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 286636002734 pyridoxal 5'-phosphate binding site [chemical binding]; other site 286636002735 homodimer interface [polypeptide binding]; other site 286636002736 catalytic residue [active] 286636002737 ATP cone domain; Region: ATP-cone; pfam03477 286636002738 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 286636002739 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 286636002740 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 286636002741 putative active site [active] 286636002742 catalytic site [active] 286636002743 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 286636002744 putative active site [active] 286636002745 catalytic site [active] 286636002746 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 286636002747 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 286636002748 Potassium binding sites [ion binding]; other site 286636002749 Cesium cation binding sites [ion binding]; other site 286636002750 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 286636002751 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 286636002752 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 286636002753 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cd00296 286636002754 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 286636002755 putative ADP-ribose binding site [chemical binding]; other site 286636002756 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 286636002757 lipoyl attachment site [posttranslational modification]; other site 286636002758 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 286636002759 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 286636002760 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 286636002761 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 286636002762 putative active site [active] 286636002763 putative FMN binding site [chemical binding]; other site 286636002764 putative substrate binding site [chemical binding]; other site 286636002765 putative catalytic residue [active] 286636002766 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 286636002767 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 286636002768 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 286636002769 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 286636002770 Flavoprotein; Region: Flavoprotein; cl08021 286636002771 Predicted membrane protein [Function unknown]; Region: COG4684 286636002772 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 286636002773 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 286636002774 active site 286636002775 substrate binding site [chemical binding]; other site 286636002776 metal binding site [ion binding]; metal-binding site 286636002777 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 286636002778 TM-ABC transporter signature motif; other site 286636002779 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 286636002780 TM-ABC transporter signature motif; other site 286636002781 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 286636002782 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 286636002783 Walker A/P-loop; other site 286636002784 ATP binding site [chemical binding]; other site 286636002785 Q-loop/lid; other site 286636002786 ABC transporter signature motif; other site 286636002787 Walker B; other site 286636002788 D-loop; other site 286636002789 H-loop/switch region; other site 286636002790 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 286636002791 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 286636002792 ligand binding site [chemical binding]; other site 286636002793 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 286636002794 active site 286636002795 catalytic motif [active] 286636002796 Zn binding site [ion binding]; other site 286636002797 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636002798 Methyltransferase domain; Region: Methyltransf_31; pfam13847 286636002799 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 286636002800 S-adenosylmethionine binding site [chemical binding]; other site 286636002801 pantothenate kinase; Provisional; Region: PRK05439 286636002802 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 286636002803 ATP-binding site [chemical binding]; other site 286636002804 CoA-binding site [chemical binding]; other site 286636002805 Mg2+-binding site [ion binding]; other site 286636002806 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 286636002807 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 286636002808 dimer interface [polypeptide binding]; other site 286636002809 phosphorylation site [posttranslational modification] 286636002810 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 286636002811 ATP binding site [chemical binding]; other site 286636002812 Mg2+ binding site [ion binding]; other site 286636002813 G-X-G motif; other site 286636002814 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 286636002815 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 286636002816 active site 286636002817 phosphorylation site [posttranslational modification] 286636002818 intermolecular recognition site; other site 286636002819 dimerization interface [polypeptide binding]; other site 286636002820 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 286636002821 DNA binding site [nucleotide binding] 286636002822 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 286636002823 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 286636002824 Zn binding site [ion binding]; other site 286636002825 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 286636002826 PhoU domain; Region: PhoU; pfam01895 286636002827 PhoU domain; Region: PhoU; pfam01895 286636002828 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 286636002829 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 286636002830 Walker A/P-loop; other site 286636002831 ATP binding site [chemical binding]; other site 286636002832 Q-loop/lid; other site 286636002833 ABC transporter signature motif; other site 286636002834 Walker B; other site 286636002835 D-loop; other site 286636002836 H-loop/switch region; other site 286636002837 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 286636002838 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 286636002839 Walker A/P-loop; other site 286636002840 ATP binding site [chemical binding]; other site 286636002841 Q-loop/lid; other site 286636002842 ABC transporter signature motif; other site 286636002843 Walker B; other site 286636002844 D-loop; other site 286636002845 H-loop/switch region; other site 286636002846 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 286636002847 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 286636002848 dimer interface [polypeptide binding]; other site 286636002849 conserved gate region; other site 286636002850 putative PBP binding loops; other site 286636002851 ABC-ATPase subunit interface; other site 286636002852 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 286636002853 dimer interface [polypeptide binding]; other site 286636002854 conserved gate region; other site 286636002855 putative PBP binding loops; other site 286636002856 ABC-ATPase subunit interface; other site 286636002857 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 286636002858 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 286636002859 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 286636002860 S-adenosylmethionine binding site [chemical binding]; other site 286636002861 Uncharacterized conserved protein [Function unknown]; Region: COG3270 286636002862 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 286636002863 active site 286636002864 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 286636002865 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 286636002866 ArsC family; Region: ArsC; pfam03960 286636002867 putative catalytic residues [active] 286636002868 thiol/disulfide switch; other site 286636002869 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 286636002870 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 286636002871 active site 286636002872 Riboflavin kinase; Region: Flavokinase; cl03312 286636002873 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 286636002874 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 286636002875 RNA binding site [nucleotide binding]; other site 286636002876 active site 286636002877 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 286636002878 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 286636002879 Predicted membrane protein [Function unknown]; Region: COG4129 286636002880 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 286636002881 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 286636002882 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 286636002883 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 286636002884 FtsX-like permease family; Region: FtsX; cl15850 286636002885 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 286636002886 FtsX-like permease family; Region: FtsX; cl15850 286636002887 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 286636002888 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 286636002889 Walker A/P-loop; other site 286636002890 ATP binding site [chemical binding]; other site 286636002891 Q-loop/lid; other site 286636002892 ABC transporter signature motif; other site 286636002893 Walker B; other site 286636002894 D-loop; other site 286636002895 H-loop/switch region; other site 286636002896 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 286636002897 Helix-turn-helix domains; Region: HTH; cl00088 286636002898 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 286636002899 DNA-binding site [nucleotide binding]; DNA binding site 286636002900 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 286636002901 Protein of unknown function (DUF322); Region: DUF322; cl00574 286636002902 CsbD-like; Region: CsbD; cl01888 286636002903 Protein of unknown function (DUF322); Region: DUF322; cl00574 286636002904 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 286636002905 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 286636002906 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 286636002907 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 286636002908 Family description; Region: UvrD_C_2; cl15862 286636002909 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 286636002910 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 286636002911 Cation efflux family; Region: Cation_efflux; cl00316 286636002912 Helix-turn-helix domains; Region: HTH; cl00088 286636002913 Helix-turn-helix domains; Region: HTH; cl00088 286636002914 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 286636002915 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 286636002916 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 286636002917 active site 286636002918 P-loop; other site 286636002919 phosphorylation site [posttranslational modification] 286636002920 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 286636002921 active site 286636002922 P-loop; other site 286636002923 phosphorylation site [posttranslational modification] 286636002924 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 286636002925 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 286636002926 glutaminase active site [active] 286636002927 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 286636002928 dimer interface [polypeptide binding]; other site 286636002929 active site 286636002930 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 286636002931 dimer interface [polypeptide binding]; other site 286636002932 active site 286636002933 Transposase domain (DUF772); Region: DUF772; cl15789 286636002934 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 286636002935 Transposase domain (DUF772); Region: DUF772; cl15789 286636002936 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 286636002937 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 286636002938 pyruvate kinase; Provisional; Region: PRK05826 286636002939 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 286636002940 domain interfaces; other site 286636002941 active site 286636002942 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 286636002943 active site 286636002944 ADP/pyrophosphate binding site [chemical binding]; other site 286636002945 dimerization interface [polypeptide binding]; other site 286636002946 allosteric effector site; other site 286636002947 fructose-1,6-bisphosphate binding site; other site 286636002948 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279 286636002949 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 286636002950 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 286636002951 generic binding surface II; other site 286636002952 generic binding surface I; other site 286636002953 Predicted transcriptional regulators [Transcription]; Region: COG1725 286636002954 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 286636002955 DNA-binding site [nucleotide binding]; DNA binding site 286636002956 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 286636002957 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 286636002958 Walker A/P-loop; other site 286636002959 ATP binding site [chemical binding]; other site 286636002960 Q-loop/lid; other site 286636002961 ABC transporter signature motif; other site 286636002962 Walker B; other site 286636002963 D-loop; other site 286636002964 H-loop/switch region; other site 286636002965 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 286636002966 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 286636002967 PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a...; Region: PLA2_like; cl05417 286636002968 primary metal binding site; other site 286636002969 catalytic residues [active] 286636002970 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 286636002971 NlpC/P60 family; Region: NLPC_P60; cl11438 286636002972 Bacterial SH3 domain; Region: SH3_3; cl02551 286636002973 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 286636002974 Holin family; Region: Phage_holin_4; cl01989 286636002975 Protein of unknown function (DUF1617); Region: DUF1617; pfam07761 286636002976 gp58-like protein; Region: Gp58; pfam07902 286636002977 Hyaluronidase protein (HylP); Region: Hyaluronidase_1; pfam07212 286636002978 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 286636002979 Phage-related protein [Function unknown]; Region: COG4722; cl15832 286636002980 Phage tail protein; Region: Sipho_tail; pfam05709 286636002981 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 286636002982 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 286636002983 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 286636002984 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 286636002985 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 286636002986 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 286636002987 Phage capsid family; Region: Phage_capsid; pfam05065 286636002988 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 286636002989 oligomer interface [polypeptide binding]; other site 286636002990 active site residues [active] 286636002991 Phage portal protein; Region: Phage_portal; pfam04860 286636002992 Phage-related protein [Function unknown]; Region: COG4695; cl01923 286636002993 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 286636002994 Phage Terminase; Region: Terminase_1; pfam03354 286636002995 Phage terminase, small subunit; Region: Terminase_4; cl01525 286636002996 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 286636002997 active site 286636002998 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 286636002999 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 286636003000 sequence-specific DNA binding site [nucleotide binding]; other site 286636003001 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 286636003002 non-specific DNA binding site [nucleotide binding]; other site 286636003003 salt bridge; other site 286636003004 sequence-specific DNA binding site [nucleotide binding]; other site 286636003005 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 286636003006 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 286636003007 non-specific DNA binding site [nucleotide binding]; other site 286636003008 salt bridge; other site 286636003009 sequence-specific DNA binding site [nucleotide binding]; other site 286636003010 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 286636003011 Catalytic site [active] 286636003012 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 286636003013 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 286636003014 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 286636003015 Int/Topo IB signature motif; other site 286636003016 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 286636003017 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 286636003018 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 286636003019 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 286636003020 Transcriptional regulators [Transcription]; Region: PurR; COG1609 286636003021 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 286636003022 DNA binding site [nucleotide binding] 286636003023 domain linker motif; other site 286636003024 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 286636003025 putative dimerization interface [polypeptide binding]; other site 286636003026 putative ligand binding site [chemical binding]; other site 286636003027 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 286636003028 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 286636003029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 286636003030 dimer interface [polypeptide binding]; other site 286636003031 conserved gate region; other site 286636003032 ABC-ATPase subunit interface; other site 286636003033 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 286636003034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 286636003035 dimer interface [polypeptide binding]; other site 286636003036 conserved gate region; other site 286636003037 putative PBP binding loops; other site 286636003038 ABC-ATPase subunit interface; other site 286636003039 Helix-turn-helix domains; Region: HTH; cl00088 286636003040 Integrase core domain; Region: rve; cl01316 286636003041 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 286636003042 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 286636003043 DltD N-terminal region; Region: DltD_N; pfam04915 286636003044 DltD central region; Region: DltD_M; pfam04918 286636003045 DltD C-terminal region; Region: DltD_C; pfam04914 286636003046 Phosphopantetheine attachment site; Region: PP-binding; cl09936 286636003047 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 286636003048 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 286636003049 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 286636003050 excinuclease ABC subunit B; Provisional; Region: PRK05298 286636003051 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 286636003052 ATP binding site [chemical binding]; other site 286636003053 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 286636003054 nucleotide binding region [chemical binding]; other site 286636003055 ATP-binding site [chemical binding]; other site 286636003056 Ultra-violet resistance protein B; Region: UvrB; pfam12344 286636003057 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 286636003058 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 286636003059 substrate binding pocket [chemical binding]; other site 286636003060 membrane-bound complex binding site; other site 286636003061 hinge residues; other site 286636003062 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 286636003063 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 286636003064 substrate binding pocket [chemical binding]; other site 286636003065 membrane-bound complex binding site; other site 286636003066 hinge residues; other site 286636003067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 286636003068 dimer interface [polypeptide binding]; other site 286636003069 conserved gate region; other site 286636003070 putative PBP binding loops; other site 286636003071 ABC-ATPase subunit interface; other site 286636003072 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 286636003073 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 286636003074 Walker A/P-loop; other site 286636003075 ATP binding site [chemical binding]; other site 286636003076 Q-loop/lid; other site 286636003077 ABC transporter signature motif; other site 286636003078 Walker B; other site 286636003079 D-loop; other site 286636003080 H-loop/switch region; other site 286636003081 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 286636003082 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 286636003083 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 286636003084 hydrophobic ligand binding site; other site 286636003085 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 286636003086 active site 286636003087 methionine cluster; other site 286636003088 phosphorylation site [posttranslational modification] 286636003089 metal binding site [ion binding]; metal-binding site 286636003090 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 286636003091 active site 286636003092 P-loop; other site 286636003093 phosphorylation site [posttranslational modification] 286636003094 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 286636003095 Helix-turn-helix domains; Region: HTH; cl00088 286636003096 Helix-turn-helix domains; Region: HTH; cl00088 286636003097 PRD domain; Region: PRD; cl15445 286636003098 PRD domain; Region: PRD; cl15445 286636003099 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 286636003100 P-loop; other site 286636003101 active site 286636003102 phosphorylation site [posttranslational modification] 286636003103 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 286636003104 active site 286636003105 phosphorylation site [posttranslational modification] 286636003106 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 286636003107 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 286636003108 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 286636003109 GTPase CgtA; Reviewed; Region: obgE; PRK12297 286636003110 GTP1/OBG; Region: GTP1_OBG; pfam01018 286636003111 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 286636003112 G1 box; other site 286636003113 GTP/Mg2+ binding site [chemical binding]; other site 286636003114 Switch I region; other site 286636003115 G2 box; other site 286636003116 G3 box; other site 286636003117 Switch II region; other site 286636003118 G4 box; other site 286636003119 G5 box; other site 286636003120 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 286636003121 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 286636003122 Helix-turn-helix domains; Region: HTH; cl00088 286636003123 HTH-like domain; Region: HTH_21; pfam13276 286636003124 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 286636003125 Integrase core domain; Region: rve; cl01316 286636003126 Integrase core domain; Region: rve_3; cl15866 286636003127 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06559 286636003128 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 286636003129 dimerization interface [polypeptide binding]; other site 286636003130 active site 286636003131 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 286636003132 transmembrane helices; other site 286636003133 Helix-turn-helix domains; Region: HTH; cl00088 286636003134 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 286636003135 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 286636003136 RNA binding surface [nucleotide binding]; other site 286636003137 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 286636003138 active site 286636003139 uracil binding [chemical binding]; other site 286636003140 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 286636003141 benzoate transport; Region: 2A0115; TIGR00895 286636003142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 286636003143 putative substrate translocation pore; other site 286636003144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 286636003145 hypothetical protein; Provisional; Region: PRK13663 286636003146 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 286636003147 CoenzymeA binding site [chemical binding]; other site 286636003148 subunit interaction site [polypeptide binding]; other site 286636003149 PHB binding site; other site 286636003150 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 286636003151 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 286636003152 TRAM domain; Region: TRAM; cl01282 286636003153 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 286636003154 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 286636003155 shikimate kinase; Reviewed; Region: aroK; PRK00131 286636003156 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 286636003157 ADP binding site [chemical binding]; other site 286636003158 magnesium binding site [ion binding]; other site 286636003159 putative shikimate binding site; other site 286636003160 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 286636003161 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 286636003162 hinge; other site 286636003163 active site 286636003164 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 286636003165 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 286636003166 active site 286636003167 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 286636003168 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 286636003169 DNA-binding site [nucleotide binding]; DNA binding site 286636003170 DRTGG domain; Region: DRTGG; cl12147 286636003171 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 286636003172 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 286636003173 active site 2 [active] 286636003174 active site 1 [active] 286636003175 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 286636003176 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 286636003177 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 286636003178 Helix-turn-helix domains; Region: HTH; cl00088 286636003179 Integrase core domain; Region: rve; cl01316 286636003180 Gram positive anchor; Region: Gram_pos_anchor; cl15427 286636003181 Transposase domain (DUF772); Region: DUF772; cl15789 286636003182 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 286636003183 Transposase domain (DUF772); Region: DUF772; cl15789 286636003184 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 286636003185 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 286636003186 hinge; other site 286636003187 active site 286636003188 S-adenosylmethionine synthetase; Validated; Region: PRK05250 286636003189 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 286636003190 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 286636003191 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 286636003192 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 286636003193 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 286636003194 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 286636003195 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 286636003196 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 286636003197 Helix-turn-helix domains; Region: HTH; cl00088 286636003198 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 286636003199 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 286636003200 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 286636003201 Protein of unknown function (DUF3272); Region: DUF3272; pfam11676 286636003202 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 286636003203 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 286636003204 Walker A motif; other site 286636003205 ATP binding site [chemical binding]; other site 286636003206 Walker B motif; other site 286636003207 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 286636003208 arginine finger; other site 286636003209 GAF domain; Region: GAF; cl00853 286636003210 Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810 286636003211 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 286636003212 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 286636003213 Sugar specificity; other site 286636003214 Pyrimidine base specificity; other site 286636003215 ATP-binding site [chemical binding]; other site 286636003216 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 286636003217 ATP binding site [chemical binding]; other site 286636003218 putative Mg++ binding site [ion binding]; other site 286636003219 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 286636003220 nucleotide binding region [chemical binding]; other site 286636003221 ATP-binding site [chemical binding]; other site 286636003222 Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947 286636003223 NodB motif; other site 286636003224 active site 286636003225 catalytic site [active] 286636003226 Zn binding site [ion binding]; other site 286636003227 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 286636003228 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 286636003229 tetrameric interface [polypeptide binding]; other site 286636003230 activator binding site; other site 286636003231 NADP binding site [chemical binding]; other site 286636003232 substrate binding site [chemical binding]; other site 286636003233 catalytic residues [active] 286636003234 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 286636003235 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 286636003236 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 286636003237 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 286636003238 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 286636003239 dimerization domain swap beta strand [polypeptide binding]; other site 286636003240 regulatory protein interface [polypeptide binding]; other site 286636003241 active site 286636003242 regulatory phosphorylation site [posttranslational modification]; other site 286636003243 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 286636003244 catalytic residues [active] 286636003245 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 286636003246 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 286636003247 Class I ribonucleotide reductase; Region: RNR_I; cd01679 286636003248 active site 286636003249 dimer interface [polypeptide binding]; other site 286636003250 catalytic residues [active] 286636003251 effector binding site; other site 286636003252 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 286636003253 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 286636003254 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 286636003255 dimer interface [polypeptide binding]; other site 286636003256 putative radical transfer pathway; other site 286636003257 diiron center [ion binding]; other site 286636003258 tyrosyl radical; other site 286636003259 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 286636003260 putative ion selectivity filter; other site 286636003261 putative pore gating glutamate residue; other site 286636003262 Helix-turn-helix domains; Region: HTH; cl00088 286636003263 putative transposase OrfB; Reviewed; Region: PHA02517 286636003264 HTH-like domain; Region: HTH_21; pfam13276 286636003265 Integrase core domain; Region: rve; cl01316 286636003266 Integrase core domain; Region: rve_3; cl15866 286636003267 CAAX protease self-immunity; Region: Abi; cl00558 286636003268 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 286636003269 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 286636003270 non-specific DNA binding site [nucleotide binding]; other site 286636003271 salt bridge; other site 286636003272 sequence-specific DNA binding site [nucleotide binding]; other site 286636003273 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 286636003274 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 286636003275 motif 1; other site 286636003276 active site 286636003277 motif 2; other site 286636003278 motif 3; other site 286636003279 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 286636003280 DHHA1 domain; Region: DHHA1; pfam02272 286636003281 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 286636003282 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 286636003283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 286636003284 S-adenosylmethionine binding site [chemical binding]; other site 286636003285 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 286636003286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 286636003287 putative substrate translocation pore; other site 286636003288 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 286636003289 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 286636003290 active site 286636003291 Zn binding site [ion binding]; other site 286636003292 Competence protein CoiA-like family; Region: CoiA; cl11541 286636003293 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 286636003294 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 286636003295 RNA binding surface [nucleotide binding]; other site 286636003296 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 286636003297 active site 286636003298 uracil binding [chemical binding]; other site 286636003299 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 286636003300 active site 286636003301 trimer interface [polypeptide binding]; other site 286636003302 allosteric site; other site 286636003303 active site lid [active] 286636003304 hexamer (dimer of trimers) interface [polypeptide binding]; other site 286636003305 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 286636003306 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 286636003307 Protein of unknown function (DUF3114); Region: DUF3114; pfam11311 286636003308 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 286636003309 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 286636003310 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 286636003311 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 286636003312 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 286636003313 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 286636003314 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 286636003315 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 286636003316 active site 286636003317 conformational flexibility of ligand binding pocket; other site 286636003318 ADP-ribosylating toxin turn-turn motif; other site 286636003319 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 286636003320 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 286636003321 catalytic residues [active] 286636003322 catalytic nucleophile [active] 286636003323 Recombinase; Region: Recombinase; pfam07508 286636003324 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 286636003325 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 286636003326 catalytic residues [active] 286636003327 catalytic nucleophile [active] 286636003328 Recombinase; Region: Recombinase; pfam07508 286636003329 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 286636003330 NlpC/P60 family; Region: NLPC_P60; cl11438 286636003331 Siphovirus protein of unknown function (DUF859); Region: DUF859; pfam05895 286636003332 Holin family; Region: Phage_holin_4; cl01989 286636003333 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 286636003334 Phage-related protein [Function unknown]; Region: COG4722; cl15832 286636003335 Phage-related minor tail protein [Function unknown]; Region: COG5280 286636003336 Phage-related minor tail protein [Function unknown]; Region: COG5280 286636003337 membrane protein P6; Region: PHA01399 286636003338 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 286636003339 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 286636003340 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 286636003341 oligomerization interface [polypeptide binding]; other site 286636003342 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 286636003343 Phage capsid family; Region: Phage_capsid; pfam05065 286636003344 Clp protease; Region: CLP_protease; pfam00574 286636003345 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 286636003346 oligomer interface [polypeptide binding]; other site 286636003347 active site residues [active] 286636003348 Phage-related protein [Function unknown]; Region: COG4695; cl01923 286636003349 Phage portal protein; Region: Phage_portal; pfam04860 286636003350 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 286636003351 Phage Terminase; Region: Terminase_1; pfam03354 286636003352 Phage terminase, small subunit; Region: Terminase_4; cl01525 286636003353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 286636003354 cofactor binding site; other site 286636003355 DNA binding site [nucleotide binding] 286636003356 substrate interaction site [chemical binding]; other site 286636003357 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 286636003358 ParB-like nuclease domain; Region: ParBc; cl02129 286636003359 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 286636003360 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636003361 Predicted transcriptional regulator [General function prediction only]; Region: COG2522 286636003362 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 286636003363 active site 286636003364 S-adenosylmethionine synthetase; Provisional; Region: PRK12459 286636003365 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 286636003366 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 286636003367 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 286636003368 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 286636003369 ATP binding site [chemical binding]; other site 286636003370 putative Mg++ binding site [ion binding]; other site 286636003371 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 286636003372 nucleotide binding region [chemical binding]; other site 286636003373 ATP-binding site [chemical binding]; other site 286636003374 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 286636003375 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 286636003376 D5 N terminal like; Region: D5_N; cl07360 286636003377 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 286636003378 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 286636003379 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 286636003380 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 286636003381 active site 286636003382 DNA binding site [nucleotide binding] 286636003383 catalytic site [active] 286636003384 LlaJI restriction endonuclease; Region: RE_LlaJI; pfam09563 286636003385 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 286636003386 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 286636003387 non-specific DNA binding site [nucleotide binding]; other site 286636003388 salt bridge; other site 286636003389 sequence-specific DNA binding site [nucleotide binding]; other site 286636003390 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 286636003391 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 286636003392 cofactor binding site; other site 286636003393 DNA binding site [nucleotide binding] 286636003394 substrate interaction site [chemical binding]; other site 286636003395 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 286636003396 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 286636003397 non-specific DNA binding site [nucleotide binding]; other site 286636003398 salt bridge; other site 286636003399 sequence-specific DNA binding site [nucleotide binding]; other site 286636003400 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 286636003401 Catalytic site [active] 286636003402 DNA polymerase IV; Reviewed; Region: PRK03103 286636003403 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 286636003404 active site 286636003405 DNA binding site [nucleotide binding] 286636003406 YolD-like protein; Region: YolD; pfam08863 286636003407 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 286636003408 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 286636003409 ABC transporter; Region: ABC_tran_2; pfam12848 286636003410 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 286636003411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 286636003412 H+ Antiporter protein; Region: 2A0121; TIGR00900 286636003413 putative substrate translocation pore; other site 286636003414 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 286636003415 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 286636003416 catalytic residues [active] 286636003417 catalytic nucleophile [active] 286636003418 Recombinase; Region: Recombinase; pfam07508 286636003419 CpXC protein; Region: CpXC; pfam14353 286636003420 Recombinase; Region: Recombinase; pfam07508 286636003421 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 286636003422 phosphodiesterase; Provisional; Region: PRK12704 286636003423 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 286636003424 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 286636003425 Competence protein; Region: Competence; cl00471 286636003426 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 286636003427 SLBB domain; Region: SLBB; pfam10531 286636003428 comEA protein; Region: comE; TIGR01259 286636003429 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 286636003430 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 286636003431 putative acyl-acceptor binding pocket; other site 286636003432 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 286636003433 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636003434 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 286636003435 GIY-YIG motif/motif A; other site 286636003436 putative active site [active] 286636003437 putative metal binding site [ion binding]; other site 286636003438 K+ potassium transporter; Region: K_trans; cl15781 286636003439 helicase 45; Provisional; Region: PTZ00424 286636003440 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 286636003441 ATP binding site [chemical binding]; other site 286636003442 Mg++ binding site [ion binding]; other site 286636003443 motif III; other site 286636003444 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 286636003445 nucleotide binding region [chemical binding]; other site 286636003446 ATP-binding site [chemical binding]; other site 286636003447 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 286636003448 RF3 subfamily. Peptide chain release factor 3 (RF3) is a protein involved in the termination step of translation in bacteria. Termination occurs when class I release factors (RF1 or RF2) recognize the stop codon at the A-site of the ribosome and...; Region: RF3; cd04169 286636003449 G1 box; other site 286636003450 putative GEF interaction site [polypeptide binding]; other site 286636003451 GTP/Mg2+ binding site [chemical binding]; other site 286636003452 Switch I region; other site 286636003453 G2 box; other site 286636003454 G3 box; other site 286636003455 Switch II region; other site 286636003456 G4 box; other site 286636003457 G5 box; other site 286636003458 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 286636003459 Predicted integral membrane protein [Function unknown]; Region: COG5522; cl02331 286636003460 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 286636003461 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 286636003462 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 286636003463 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 286636003464 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 286636003465 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 286636003466 ATP-grasp domain; Region: ATP-grasp_4; cl03087 286636003467 recombination protein RecR; Reviewed; Region: recR; PRK00076 286636003468 RecR protein; Region: RecR; pfam02132 286636003469 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 286636003470 putative active site [active] 286636003471 putative metal-binding site [ion binding]; other site 286636003472 tetramer interface [polypeptide binding]; other site 286636003473 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 286636003474 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 286636003475 Helix-turn-helix domains; Region: HTH; cl00088 286636003476 3H domain; Region: 3H; pfam02829 286636003477 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 286636003478 catalytic core [active] 286636003479 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 286636003480 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 286636003481 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 286636003482 active site 286636003483 FMN binding site [chemical binding]; other site 286636003484 substrate binding site [chemical binding]; other site 286636003485 catalytic residues [active] 286636003486 homodimer interface [polypeptide binding]; other site 286636003487 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 286636003488 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 286636003489 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 286636003490 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 286636003491 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 286636003492 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 286636003493 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 286636003494 Transposase domain (DUF772); Region: DUF772; cl15789 286636003495 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 286636003496 Transposase domain (DUF772); Region: DUF772; cl15789 286636003497 NlpC/P60 family; Region: NLPC_P60; cl11438 286636003498 Bacterial SH3 domain; Region: SH3_3; cl02551 286636003499 Holin family; Region: Phage_holin_4; cl01989 286636003500 Protein of unknown function (DUF1617); Region: DUF1617; pfam07761 286636003501 gp58-like protein; Region: Gp58; pfam07902 286636003502 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 286636003503 Hyaluronidase protein (HylP); Region: Hyaluronidase_1; pfam07212 286636003504 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 286636003505 Phage-related protein [Function unknown]; Region: COG4722; cl15832 286636003506 Phage-related protein [Function unknown]; Region: COG5412 286636003507 Herpesvirus Glycoprotein B; Region: Glycoprotein_B; pfam00606 286636003508 Phage protein Gp19/Gp15/Gp42; Region: Phage_Gp19; pfam09355 286636003509 HeH/LEM domain; Region: HeH; pfam12949 286636003510 Phage capsid family; Region: Phage_capsid; pfam05065 286636003511 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 286636003512 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 286636003513 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 286636003514 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 286636003515 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 286636003516 active site 286636003517 Protein of unknown function (DUF1492); Region: DUF1492; pfam07374 286636003518 Protein of unknown function (DUF1372); Region: DUF1372; pfam07116 286636003519 PcfK-like protein; Region: PcfK; pfam14058 286636003520 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 286636003521 RecT family; Region: RecT; cl04285 286636003522 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 286636003523 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 286636003524 Int/Topo IB signature motif; other site 286636003525 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 286636003526 IHF dimer interface [polypeptide binding]; other site 286636003527 IHF - DNA interface [nucleotide binding]; other site 286636003528 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 286636003529 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 286636003530 active site 286636003531 catalytic triad [active] 286636003532 oxyanion hole [active] 286636003533 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 286636003534 Gram positive anchor; Region: Gram_pos_anchor; cl15427 286636003535 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 286636003536 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 286636003537 Walker A/P-loop; other site 286636003538 ATP binding site [chemical binding]; other site 286636003539 Q-loop/lid; other site 286636003540 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 286636003541 ABC transporter signature motif; other site 286636003542 Walker B; other site 286636003543 D-loop; other site 286636003544 H-loop/switch region; other site 286636003545 Arginine repressor [Transcription]; Region: ArgR; COG1438 286636003546 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 286636003547 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 286636003548 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 286636003549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 286636003550 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 286636003551 substrate binding pocket [chemical binding]; other site 286636003552 chain length determination region; other site 286636003553 substrate-Mg2+ binding site; other site 286636003554 catalytic residues [active] 286636003555 aspartate-rich region 1; other site 286636003556 active site lid residues [active] 286636003557 aspartate-rich region 2; other site 286636003558 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 286636003559 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 286636003560 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 286636003561 generic binding surface II; other site 286636003562 generic binding surface I; other site 286636003563 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 286636003564 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 286636003565 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 286636003566 homodimer interface [polypeptide binding]; other site 286636003567 NADP binding site [chemical binding]; other site 286636003568 substrate binding site [chemical binding]; other site 286636003569 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 286636003570 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 286636003571 active site 286636003572 substrate binding site [chemical binding]; other site 286636003573 metal binding site [ion binding]; metal-binding site 286636003574 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 286636003575 DNA photolyase; Region: DNA_photolyase; pfam00875 286636003576 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 286636003577 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 286636003578 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 286636003579 Walker A/P-loop; other site 286636003580 ATP binding site [chemical binding]; other site 286636003581 Q-loop/lid; other site 286636003582 ABC transporter signature motif; other site 286636003583 Walker B; other site 286636003584 D-loop; other site 286636003585 H-loop/switch region; other site 286636003586 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 286636003587 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 286636003588 dimer interface [polypeptide binding]; other site 286636003589 conserved gate region; other site 286636003590 putative PBP binding loops; other site 286636003591 ABC-ATPase subunit interface; other site 286636003592 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 286636003593 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 286636003594 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 286636003595 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 286636003596 Walker A motif; other site 286636003597 ATP binding site [chemical binding]; other site 286636003598 Walker B motif; other site 286636003599 arginine finger; other site 286636003600 Helicase subunit of the DNA excision repair complex [DNA replication, recombination, and repair]; Region: UvrB; COG0556 286636003601 UvrB/uvrC motif; Region: UVR; pfam02151 286636003602 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 286636003603 Walker A motif; other site 286636003604 ATP binding site [chemical binding]; other site 286636003605 Walker B motif; other site 286636003606 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 286636003607 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 286636003608 nudix motif; other site 286636003609 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 286636003610 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 286636003611 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 286636003612 active site 286636003613 HIGH motif; other site 286636003614 nucleotide binding site [chemical binding]; other site 286636003615 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 286636003616 active site 286636003617 KMSKS motif; other site 286636003618 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 286636003619 tRNA binding surface [nucleotide binding]; other site 286636003620 anticodon binding site; other site 286636003621 DivIVA protein; Region: DivIVA; pfam05103 286636003622 DivIVA domain; Region: DivI1A_domain; TIGR03544 286636003623 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 286636003624 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 286636003625 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 286636003626 YGGT family; Region: YGGT; cl00508 286636003627 Protein of unknown function (DUF552); Region: DUF552; cl00775 286636003628 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 286636003629 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 286636003630 catalytic residue [active] 286636003631 cell division protein FtsZ; Validated; Region: PRK09330 286636003632 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 286636003633 nucleotide binding site [chemical binding]; other site 286636003634 SulA interaction site; other site 286636003635 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 286636003636 Cell division protein FtsA; Region: FtsA; cl11496 286636003637 Cell division protein FtsA; Region: FtsA; cl11496 286636003638 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 286636003639 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 286636003640 Cell division protein FtsQ; Region: FtsQ; pfam03799 286636003641 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 286636003642 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 286636003643 active site 286636003644 homodimer interface [polypeptide binding]; other site 286636003645 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 286636003646 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 286636003647 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 286636003648 Protein of unknown function (DUF3165); Region: DUF3165; pfam11364 286636003649 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 286636003650 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 286636003651 G1 box; other site 286636003652 putative GEF interaction site [polypeptide binding]; other site 286636003653 GTP/Mg2+ binding site [chemical binding]; other site 286636003654 Switch I region; other site 286636003655 G2 box; other site 286636003656 G3 box; other site 286636003657 Switch II region; other site 286636003658 G4 box; other site 286636003659 G5 box; other site 286636003660 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 286636003661 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 286636003662 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 286636003663 active site residue [active] 286636003664 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 286636003665 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 286636003666 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 286636003667 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 286636003668 Ferritin-like domain; Region: Ferritin; pfam00210 286636003669 dimerization interface [polypeptide binding]; other site 286636003670 DPS ferroxidase diiron center [ion binding]; other site 286636003671 ion pore; other site 286636003672 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 286636003673 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 286636003674 FeS/SAM binding site; other site 286636003675 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 286636003676 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 286636003677 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 286636003678 DNA binding site [nucleotide binding] 286636003679 domain linker motif; other site 286636003680 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 286636003681 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 286636003682 protein binding site [polypeptide binding]; other site 286636003683 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 286636003684 pantetheine-phosphate adenylyltransferase, bacterial; Region: coaD_prev_kdtB; TIGR01510 286636003685 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 286636003686 active site 286636003687 (T/H)XGH motif; other site 286636003688 Predicted archaeal methyltransferase [General function prediction only]; Region: COG2521 286636003689 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 286636003690 S-adenosylmethionine binding site [chemical binding]; other site 286636003691 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 286636003692 dimer interface [polypeptide binding]; other site 286636003693 active site 286636003694 carbamate kinase; Reviewed; Region: PRK12686 286636003695 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 286636003696 putative substrate binding site [chemical binding]; other site 286636003697 nucleotide binding site [chemical binding]; other site 286636003698 nucleotide binding site [chemical binding]; other site 286636003699 homodimer interface [polypeptide binding]; other site 286636003700 hypothetical protein; Provisional; Region: PRK07205 286636003701 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 286636003702 active site 286636003703 metal binding site [ion binding]; metal-binding site 286636003704 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 286636003705 ornithine carbamoyltransferase; Validated; Region: PRK02102 286636003706 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 286636003707 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636003708 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 286636003709 Amidinotransferase; Region: Amidinotransf; cl12043 286636003710 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 286636003711 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 286636003712 ligand binding site [chemical binding]; other site 286636003713 flexible hinge region; other site 286636003714 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 286636003715 putative switch regulator; other site 286636003716 non-specific DNA interactions [nucleotide binding]; other site 286636003717 DNA binding site [nucleotide binding] 286636003718 sequence specific DNA binding site [nucleotide binding]; other site 286636003719 putative cAMP binding site [chemical binding]; other site 286636003720 Arginine repressor [Transcription]; Region: ArgR; COG1438 286636003721 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 286636003722 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 286636003723 B3/4 domain; Region: B3_4; cl11458 286636003724 Protein of unknown function (DUF419); Region: DUF419; cl15265 286636003725 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 286636003726 Cache domain; Region: Cache_1; pfam02743 286636003727 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 286636003728 Histidine kinase; Region: His_kinase; pfam06580 286636003729 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 286636003730 ATP binding site [chemical binding]; other site 286636003731 Mg2+ binding site [ion binding]; other site 286636003732 G-X-G motif; other site 286636003733 Response regulator receiver domain; Region: Response_reg; pfam00072 286636003734 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 286636003735 active site 286636003736 phosphorylation site [posttranslational modification] 286636003737 intermolecular recognition site; other site 286636003738 dimerization interface [polypeptide binding]; other site 286636003739 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 286636003740 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 286636003741 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 286636003742 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 286636003743 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 286636003744 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 286636003745 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 286636003746 catalytic residues [active] 286636003747 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 286636003748 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 286636003749 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 286636003750 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636003751 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 286636003752 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 286636003753 active site 286636003754 HIGH motif; other site 286636003755 nucleotide binding site [chemical binding]; other site 286636003756 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 286636003757 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 286636003758 active site 286636003759 KMSKS motif; other site 286636003760 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 286636003761 tRNA binding surface [nucleotide binding]; other site 286636003762 anticodon binding site; other site 286636003763 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 286636003764 AAA domain; Region: AAA_18; pfam13238 286636003765 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 286636003766 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 286636003767 Domain of unknown function (DUF1912); Region: DUF1912; pfam08930 286636003768 NeuB family; Region: NeuB; cl00496 286636003769 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 286636003770 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 286636003771 active site 286636003772 dimer interface [polypeptide binding]; other site 286636003773 metal binding site [ion binding]; metal-binding site 286636003774 Cupin domain; Region: Cupin_2; cl09118 286636003775 Cupin domain; Region: Cupin_2; cl09118 286636003776 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 286636003777 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 286636003778 S-adenosylmethionine binding site [chemical binding]; other site 286636003779 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 286636003780 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 286636003781 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 286636003782 shikimate binding site; other site 286636003783 NAD(P) binding site [chemical binding]; other site 286636003784 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 286636003785 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 286636003786 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 286636003787 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 286636003788 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 286636003789 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 286636003790 active site 286636003791 phosphorylation site [posttranslational modification] 286636003792 intermolecular recognition site; other site 286636003793 dimerization interface [polypeptide binding]; other site 286636003794 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 286636003795 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 286636003796 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 286636003797 Histidine kinase; Region: His_kinase; pfam06580 286636003798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 286636003799 Protein of unknown function, DUF624; Region: DUF624; cl02369 286636003800 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 286636003801 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 286636003802 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 286636003803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 286636003804 dimer interface [polypeptide binding]; other site 286636003805 conserved gate region; other site 286636003806 putative PBP binding loops; other site 286636003807 ABC-ATPase subunit interface; other site 286636003808 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 286636003809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 286636003810 putative PBP binding loops; other site 286636003811 dimer interface [polypeptide binding]; other site 286636003812 ABC-ATPase subunit interface; other site 286636003813 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 286636003814 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 286636003815 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 286636003816 beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555 286636003817 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 286636003818 DNA-binding site [nucleotide binding]; DNA binding site 286636003819 Transcriptional regulators [Transcription]; Region: PurR; COG1609 286636003820 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 286636003821 ligand binding site [chemical binding]; other site 286636003822 dimerization interface [polypeptide binding]; other site 286636003823 Protein of unknown function (DUF1237); Region: DUF1237; cl15402 286636003824 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 286636003825 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 286636003826 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 286636003827 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 286636003828 GPI biosynthesis protein family Pig-F; Region: PIG-F; pfam06699 286636003829 TRAM domain; Region: TRAM; cl01282 286636003830 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 286636003831 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 286636003832 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 286636003833 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 286636003834 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 286636003835 NlpC/P60 family; Region: NLPC_P60; cl11438 286636003836 Bacterial SH3 domain; Region: SH3_3; cl02551 286636003837 Protein of unknown function (DUF1366); Region: DUF1366; pfam07104 286636003838 Protein of unknown function (DUF1617); Region: DUF1617; pfam07761 286636003839 gp58-like protein; Region: Gp58; pfam07902 286636003840 Hyaluronidase protein (HylP); Region: Hyaluronidase_1; pfam07212 286636003841 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 286636003842 Phage tail protein; Region: Sipho_tail; cl11462 286636003843 tape measure domain; Region: tape_meas_nterm; TIGR02675 286636003844 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 286636003845 Bacteriophage Gp15 protein; Region: Phage_Gp15; pfam06854 286636003846 Minor capsid protein from bacteriophage; Region: Minor_capsid_3; pfam12691 286636003847 Minor capsid protein; Region: Minor_capsid_2; pfam11114 286636003848 Minor capsid protein; Region: Minor_capsid_1; pfam10665 286636003849 Phage capsid family; Region: Phage_capsid; pfam05065 286636003850 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 286636003851 phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542 286636003852 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 286636003853 Phage terminase large subunit; Region: Terminase_3; cl12054 286636003854 Terminase-like family; Region: Terminase_6; pfam03237 286636003855 Protein of unknown function (DUF402); Region: DUF402; cl00979 286636003856 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 286636003857 30S subunit binding site; other site 286636003858 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 286636003859 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 286636003860 active site 286636003861 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 286636003862 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 286636003863 ATP binding site [chemical binding]; other site 286636003864 putative Mg++ binding site [ion binding]; other site 286636003865 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 286636003866 nucleotide binding region [chemical binding]; other site 286636003867 ATP-binding site [chemical binding]; other site 286636003868 Uncharacterized conserved protein [Function unknown]; Region: COG1739 286636003869 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 286636003870 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 286636003871 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 286636003872 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 286636003873 dimer interface [polypeptide binding]; other site 286636003874 pyridoxal 5'-phosphate binding site [chemical binding]; other site 286636003875 catalytic residue [active] 286636003876 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 286636003877 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 286636003878 RNA binding site [nucleotide binding]; other site 286636003879 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 286636003880 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 286636003881 active site 286636003882 motif I; other site 286636003883 motif II; other site 286636003884 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 286636003885 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 286636003886 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 286636003887 active site 286636003888 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 286636003889 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 286636003890 active site 286636003891 phosphorylation site [posttranslational modification] 286636003892 intermolecular recognition site; other site 286636003893 dimerization interface [polypeptide binding]; other site 286636003894 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 286636003895 DNA binding residues [nucleotide binding] 286636003896 dimerization interface [polypeptide binding]; other site 286636003897 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 286636003898 Histidine kinase; Region: HisKA_3; pfam07730 286636003899 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 286636003900 ATP binding site [chemical binding]; other site 286636003901 Mg2+ binding site [ion binding]; other site 286636003902 G-X-G motif; other site 286636003903 Predicted membrane protein (DUF2154); Region: DUF2154; cl12089 286636003904 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 286636003905 Catalytic domain of Protein Kinases; Region: PKc; cd00180 286636003906 active site 286636003907 ATP binding site [chemical binding]; other site 286636003908 substrate binding site [chemical binding]; other site 286636003909 activation loop (A-loop); other site 286636003910 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 286636003911 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 286636003912 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 286636003913 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 286636003914 active site 286636003915 16S rRNA methyltransferase B; Provisional; Region: PRK14902 286636003916 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 286636003917 putative RNA binding site [nucleotide binding]; other site 286636003918 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 286636003919 S-adenosylmethionine binding site [chemical binding]; other site 286636003920 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 286636003921 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 286636003922 putative active site [active] 286636003923 substrate binding site [chemical binding]; other site 286636003924 putative cosubstrate binding site; other site 286636003925 catalytic site [active] 286636003926 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 286636003927 substrate binding site [chemical binding]; other site 286636003928 primosome assembly protein PriA; Validated; Region: PRK05580 286636003929 primosome assembly protein PriA; Validated; Region: PRK05580 286636003930 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 286636003931 ATP binding site [chemical binding]; other site 286636003932 putative Mg++ binding site [ion binding]; other site 286636003933 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 286636003934 nucleotide binding region [chemical binding]; other site 286636003935 ATP-binding site [chemical binding]; other site 286636003936 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 286636003937 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 286636003938 catalytic site [active] 286636003939 G-X2-G-X-G-K; other site 286636003940 hypothetical protein; Provisional; Region: PRK00106 286636003941 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 286636003942 Transcriptional regulator [Transcription]; Region: LysR; COG0583 286636003943 Helix-turn-helix domains; Region: HTH; cl00088 286636003944 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 286636003945 dimerization interface [polypeptide binding]; other site 286636003946 putative acyltransferase; Provisional; Region: PRK05790 286636003947 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 286636003948 dimer interface [polypeptide binding]; other site 286636003949 active site 286636003950 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 286636003951 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 286636003952 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636003953 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 286636003954 NAD(P) binding site [chemical binding]; other site 286636003955 active site 286636003956 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 286636003957 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 286636003958 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 286636003959 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 286636003960 THUMP domain; Region: THUMP; cl12076 286636003961 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636003962 cell division protein GpsB; Provisional; Region: PRK14127 286636003963 DivIVA domain; Region: DivI1A_domain; TIGR03544 286636003964 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 286636003965 Recombination protein U; Region: RecU; cl01314 286636003966 Transglycosylase; Region: Transgly; cl07896 286636003967 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 286636003968 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 286636003969 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 286636003970 trimer interface [polypeptide binding]; other site 286636003971 active site 286636003972 G bulge; other site 286636003973 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 286636003974 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 286636003975 homodimer interface [polypeptide binding]; other site 286636003976 NAD binding pocket [chemical binding]; other site 286636003977 ATP binding pocket [chemical binding]; other site 286636003978 Mg binding site [ion binding]; other site 286636003979 active-site loop [active] 286636003980 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 286636003981 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 286636003982 active site 286636003983 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 286636003984 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 286636003985 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636003986 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 286636003987 Protein of unknown function (DUF4059); Region: DUF4059; pfam13268 286636003988 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 286636003989 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 286636003990 Walker A/P-loop; other site 286636003991 ATP binding site [chemical binding]; other site 286636003992 Q-loop/lid; other site 286636003993 ABC transporter signature motif; other site 286636003994 Walker B; other site 286636003995 D-loop; other site 286636003996 H-loop/switch region; other site 286636003997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 286636003998 dimer interface [polypeptide binding]; other site 286636003999 conserved gate region; other site 286636004000 putative PBP binding loops; other site 286636004001 ABC-ATPase subunit interface; other site 286636004002 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 286636004003 DEAD-like helicases superfamily; Region: DEXDc; smart00487 286636004004 ATP binding site [chemical binding]; other site 286636004005 Mg++ binding site [ion binding]; other site 286636004006 motif III; other site 286636004007 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 286636004008 nucleotide binding region [chemical binding]; other site 286636004009 ATP-binding site [chemical binding]; other site 286636004010 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 286636004011 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 286636004012 Mg++ binding site [ion binding]; other site 286636004013 putative catalytic motif [active] 286636004014 putative substrate binding site [chemical binding]; other site 286636004015 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 286636004016 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 286636004017 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 286636004018 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 286636004019 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 286636004020 Septum formation initiator; Region: DivIC; cl11433 286636004021 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 286636004022 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636004023 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 286636004024 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 286636004025 putative catalytic cysteine [active] 286636004026 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 286636004027 nucleotide binding site [chemical binding]; other site 286636004028 homotetrameric interface [polypeptide binding]; other site 286636004029 putative phosphate binding site [ion binding]; other site 286636004030 putative allosteric binding site; other site 286636004031 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 286636004032 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 286636004033 Walker A/P-loop; other site 286636004034 ATP binding site [chemical binding]; other site 286636004035 Q-loop/lid; other site 286636004036 ABC transporter signature motif; other site 286636004037 Walker B; other site 286636004038 D-loop; other site 286636004039 H-loop/switch region; other site 286636004040 Enterocin A Immunity; Region: EntA_Immun; pfam08951 286636004041 transketolase; Reviewed; Region: PRK05899 286636004042 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 286636004043 TPP-binding site [chemical binding]; other site 286636004044 dimer interface [polypeptide binding]; other site 286636004045 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 286636004046 PYR/PP interface [polypeptide binding]; other site 286636004047 dimer interface [polypeptide binding]; other site 286636004048 TPP binding site [chemical binding]; other site 286636004049 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 286636004050 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 286636004051 active site 286636004052 intersubunit interactions; other site 286636004053 catalytic residue [active] 286636004054 Helix-turn-helix domains; Region: HTH; cl00088 286636004055 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 286636004056 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 286636004057 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 286636004058 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 286636004059 amphipathic channel; other site 286636004060 Asn-Pro-Ala signature motifs; other site 286636004061 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 286636004062 glycerol kinase; Provisional; Region: glpK; PRK00047 286636004063 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 286636004064 N- and C-terminal domain interface [polypeptide binding]; other site 286636004065 active site 286636004066 MgATP binding site [chemical binding]; other site 286636004067 catalytic site [active] 286636004068 metal binding site [ion binding]; metal-binding site 286636004069 glycerol binding site [chemical binding]; other site 286636004070 homotetramer interface [polypeptide binding]; other site 286636004071 homodimer interface [polypeptide binding]; other site 286636004072 FBP binding site [chemical binding]; other site 286636004073 protein IIAGlc interface [polypeptide binding]; other site 286636004074 Peptidase propeptide and YPEB domain; Region: PepSY; cl15480 286636004075 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 286636004076 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 286636004077 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 286636004078 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 286636004079 dimer interface [polypeptide binding]; other site 286636004080 motif 1; other site 286636004081 active site 286636004082 motif 2; other site 286636004083 motif 3; other site 286636004084 Phospholipid methyltransferase; Region: PEMT; cl00763 286636004085 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 286636004086 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 286636004087 active site 286636004088 catalytic tetrad [active] 286636004089 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 286636004090 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 286636004091 active site 286636004092 dimer interface [polypeptide binding]; other site 286636004093 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 286636004094 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 286636004095 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 286636004096 PhoU domain; Region: PhoU; pfam01895 286636004097 PhoU domain; Region: PhoU; pfam01895 286636004098 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 286636004099 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 286636004100 Helix-turn-helix domains; Region: HTH; cl00088 286636004101 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 286636004102 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 286636004103 active site 286636004104 motif I; other site 286636004105 motif II; other site 286636004106 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 286636004107 Predicted membrane protein [Function unknown]; Region: COG2860 286636004108 UPF0126 domain; Region: UPF0126; pfam03458 286636004109 UPF0126 domain; Region: UPF0126; pfam03458 286636004110 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 286636004111 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 286636004112 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 286636004113 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 286636004114 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 286636004115 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 286636004116 P-loop; other site 286636004117 active site 286636004118 phosphorylation site [posttranslational modification] 286636004119 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 286636004120 active site 286636004121 phosphorylation site [posttranslational modification] 286636004122 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 286636004123 Helix-turn-helix domains; Region: HTH; cl00088 286636004124 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 286636004125 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 286636004126 metal-binding site [ion binding] 286636004127 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 286636004128 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 286636004129 metal-binding site [ion binding] 286636004130 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 286636004131 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 286636004132 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 286636004133 Ribosome-binding factor A; Region: RBFA; cl00542 286636004134 translation initiation factor IF-2; Validated; Region: infB; PRK05306 286636004135 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 286636004136 translation initiation factor IF-2; Region: IF-2; TIGR00487 286636004137 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 286636004138 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 286636004139 G1 box; other site 286636004140 putative GEF interaction site [polypeptide binding]; other site 286636004141 GTP/Mg2+ binding site [chemical binding]; other site 286636004142 Switch I region; other site 286636004143 G2 box; other site 286636004144 G3 box; other site 286636004145 Switch II region; other site 286636004146 G4 box; other site 286636004147 G5 box; other site 286636004148 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 286636004149 Translation-initiation factor 2; Region: IF-2; pfam11987 286636004150 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 286636004151 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 286636004152 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 286636004153 putative RNA binding cleft [nucleotide binding]; other site 286636004154 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 286636004155 NusA N-terminal domain; Region: NusA_N; pfam08529 286636004156 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 286636004157 RNA binding site [nucleotide binding]; other site 286636004158 homodimer interface [polypeptide binding]; other site 286636004159 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 286636004160 G-X-X-G motif; other site 286636004161 ribosome maturation protein RimP; Reviewed; Region: PRK00092 286636004162 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 286636004163 Sm1 motif; other site 286636004164 predicted subunit interaction site [polypeptide binding]; other site 286636004165 RNA binding pocket [nucleotide binding]; other site 286636004166 Sm2 motif; other site 286636004167 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 286636004168 S-adenosylmethionine binding site [chemical binding]; other site 286636004169 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 286636004170 Phosphotransferase enzyme family; Region: APH; pfam01636 286636004171 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 286636004172 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 286636004173 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 286636004174 Walker A/P-loop; other site 286636004175 ATP binding site [chemical binding]; other site 286636004176 Q-loop/lid; other site 286636004177 ABC transporter signature motif; other site 286636004178 Walker B; other site 286636004179 D-loop; other site 286636004180 H-loop/switch region; other site 286636004181 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 286636004182 HIT family signature motif; other site 286636004183 catalytic residue [active] 286636004184 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 286636004185 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 286636004186 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 286636004187 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 286636004188 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 286636004189 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 286636004190 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 286636004191 active site 286636004192 motif I; other site 286636004193 motif II; other site 286636004194 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 286636004195 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 286636004196 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 286636004197 active pocket/dimerization site; other site 286636004198 active site 286636004199 phosphorylation site [posttranslational modification] 286636004200 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 286636004201 active site 286636004202 phosphorylation site [posttranslational modification] 286636004203 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 286636004204 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 286636004205 Domain of unknown function (DUF956); Region: DUF956; cl01917 286636004206 seryl-tRNA synthetase; Provisional; Region: PRK05431 286636004207 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 286636004208 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 286636004209 dimer interface [polypeptide binding]; other site 286636004210 active site 286636004211 motif 1; other site 286636004212 motif 2; other site 286636004213 motif 3; other site 286636004214 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 286636004215 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 286636004216 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 286636004217 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 286636004218 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 286636004219 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 286636004220 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 286636004221 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 286636004222 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 286636004223 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 286636004224 carboxyltransferase (CT) interaction site; other site 286636004225 biotinylation site [posttranslational modification]; other site 286636004226 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 286636004227 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 286636004228 dimer interface [polypeptide binding]; other site 286636004229 active site 286636004230 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 286636004231 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 286636004232 NAD(P) binding site [chemical binding]; other site 286636004233 homotetramer interface [polypeptide binding]; other site 286636004234 homodimer interface [polypeptide binding]; other site 286636004235 active site 286636004236 Acyl transferase domain; Region: Acyl_transf_1; cl08282 286636004237 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 286636004238 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 286636004239 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 286636004240 FMN binding site [chemical binding]; other site 286636004241 substrate binding site [chemical binding]; other site 286636004242 putative catalytic residue [active] 286636004243 Phosphopantetheine attachment site; Region: PP-binding; cl09936 286636004244 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 286636004245 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 286636004246 dimer interface [polypeptide binding]; other site 286636004247 active site 286636004248 CoA binding pocket [chemical binding]; other site 286636004249 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 286636004250 Helix-turn-helix domains; Region: HTH; cl00088 286636004251 enoyl-CoA hydratase; Provisional; Region: PRK07260 286636004252 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 286636004253 substrate binding site [chemical binding]; other site 286636004254 oxyanion hole (OAH) forming residues; other site 286636004255 trimer interface [polypeptide binding]; other site 286636004256 chaperone protein DnaJ; Provisional; Region: PRK14276 286636004257 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 286636004258 HSP70 interaction site [polypeptide binding]; other site 286636004259 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 286636004260 substrate binding site [polypeptide binding]; other site 286636004261 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 286636004262 Zn binding sites [ion binding]; other site 286636004263 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 286636004264 dimer interface [polypeptide binding]; other site 286636004265 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 286636004266 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 286636004267 dimer interface [polypeptide binding]; other site 286636004268 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 286636004269 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 286636004270 HrcA protein C terminal domain; Region: HrcA; pfam01628 286636004271 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 286636004272 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 286636004273 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 286636004274 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 286636004275 catalytic core [active] 286636004276 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 286636004277 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 286636004278 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 286636004279 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 286636004280 GatB domain; Region: GatB_Yqey; cl11497 286636004281 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 286636004282 Amidase; Region: Amidase; cl11426 286636004283 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 286636004284 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 286636004285 Isochorismatase family; Region: Isochorismatase; pfam00857 286636004286 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 286636004287 catalytic triad [active] 286636004288 conserved cis-peptide bond; other site 286636004289 transcriptional repressor CodY; Validated; Region: PRK04158 286636004290 CodY GAF-like domain; Region: CodY; pfam06018 286636004291 Helix-turn-helix domains; Region: HTH; cl00088 286636004292 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 286636004293 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 286636004294 pyridoxal 5'-phosphate binding site [chemical binding]; other site 286636004295 homodimer interface [polypeptide binding]; other site 286636004296 catalytic residue [active] 286636004297 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 286636004298 Ligand Binding Site [chemical binding]; other site 286636004299 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 286636004300 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 286636004301 active site 286636004302 motif I; other site 286636004303 motif II; other site 286636004304 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 286636004305 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 286636004306 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 286636004307 active site 286636004308 homotetramer interface [polypeptide binding]; other site 286636004309 homodimer interface [polypeptide binding]; other site 286636004310 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 286636004311 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 286636004312 Walker A/P-loop; other site 286636004313 ATP binding site [chemical binding]; other site 286636004314 Q-loop/lid; other site 286636004315 ABC transporter signature motif; other site 286636004316 Walker B; other site 286636004317 D-loop; other site 286636004318 H-loop/switch region; other site 286636004319 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 286636004320 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 286636004321 generic binding surface II; other site 286636004322 ssDNA binding site; other site 286636004323 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 286636004324 ATP binding site [chemical binding]; other site 286636004325 putative Mg++ binding site [ion binding]; other site 286636004326 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 286636004327 nucleotide binding region [chemical binding]; other site 286636004328 ATP-binding site [chemical binding]; other site 286636004329 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 286636004330 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 286636004331 Walker A/P-loop; other site 286636004332 ATP binding site [chemical binding]; other site 286636004333 Q-loop/lid; other site 286636004334 ABC transporter signature motif; other site 286636004335 Walker B; other site 286636004336 D-loop; other site 286636004337 H-loop/switch region; other site 286636004338 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 286636004339 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 286636004340 Walker A/P-loop; other site 286636004341 ATP binding site [chemical binding]; other site 286636004342 Q-loop/lid; other site 286636004343 ABC transporter signature motif; other site 286636004344 Walker B; other site 286636004345 D-loop; other site 286636004346 H-loop/switch region; other site 286636004347 Cobalt transport protein; Region: CbiQ; cl00463 286636004348 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 286636004349 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 286636004350 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 286636004351 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 286636004352 Walker A/P-loop; other site 286636004353 ATP binding site [chemical binding]; other site 286636004354 Q-loop/lid; other site 286636004355 ABC transporter signature motif; other site 286636004356 Walker B; other site 286636004357 D-loop; other site 286636004358 H-loop/switch region; other site 286636004359 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 286636004360 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 286636004361 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 286636004362 Walker A/P-loop; other site 286636004363 ATP binding site [chemical binding]; other site 286636004364 Q-loop/lid; other site 286636004365 ABC transporter signature motif; other site 286636004366 Walker B; other site 286636004367 D-loop; other site 286636004368 H-loop/switch region; other site 286636004369 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 286636004370 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 286636004371 Walker A/P-loop; other site 286636004372 ATP binding site [chemical binding]; other site 286636004373 Q-loop/lid; other site 286636004374 ABC transporter signature motif; other site 286636004375 Walker B; other site 286636004376 D-loop; other site 286636004377 H-loop/switch region; other site 286636004378 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 286636004379 ABC-ATPase subunit interface; other site 286636004380 dimer interface [polypeptide binding]; other site 286636004381 putative PBP binding regions; other site 286636004382 Cell surface heme-binding protein Shp; Region: HemeBinding_Shp; pfam11545 286636004383 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 286636004384 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 286636004385 putative ligand binding residues [chemical binding]; other site 286636004386 Protein of unknown function (DUF1533); Region: DUF1533; pfam07550 286636004387 Protein of unknown function (DUF1533); Region: DUF1533; pfam07550 286636004388 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 286636004389 heme-binding site [chemical binding]; other site 286636004390 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 286636004391 Leucine-rich repeats; other site 286636004392 Leucine rich repeat; Region: LRR_8; pfam13855 286636004393 Substrate binding site [chemical binding]; other site 286636004394 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 286636004395 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 286636004396 heme-binding site [chemical binding]; other site 286636004397 Surface antigen [General function prediction only]; Region: COG3942 286636004398 NlpC/P60 family; Region: NLPC_P60; cl11438 286636004399 alanine racemase; Reviewed; Region: alr; PRK00053 286636004400 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 286636004401 active site 286636004402 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 286636004403 dimer interface [polypeptide binding]; other site 286636004404 substrate binding site [chemical binding]; other site 286636004405 catalytic residues [active] 286636004406 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 286636004407 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 286636004408 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 286636004409 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 286636004410 nucleotide binding region [chemical binding]; other site 286636004411 ATP-binding site [chemical binding]; other site 286636004412 SEC-C motif; Region: SEC-C; pfam02810 286636004413 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 286636004414 Helix-turn-helix domains; Region: HTH; cl00088 286636004415 Integrase core domain; Region: rve; cl01316 286636004416 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 286636004417 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 286636004418 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 286636004419 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 286636004420 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 286636004421 active site 286636004422 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 286636004423 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 286636004424 active site turn [active] 286636004425 phosphorylation site [posttranslational modification] 286636004426 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 286636004427 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 286636004428 HPr interaction site; other site 286636004429 glycerol kinase (GK) interaction site [polypeptide binding]; other site 286636004430 active site 286636004431 phosphorylation site [posttranslational modification] 286636004432 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 286636004433 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 286636004434 substrate binding [chemical binding]; other site 286636004435 active site 286636004436 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 286636004437 lac repressor; Reviewed; Region: lacI; PRK09526 286636004438 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 286636004439 DNA binding site [nucleotide binding] 286636004440 domain linker motif; other site 286636004441 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 286636004442 dimerization interface [polypeptide binding]; other site 286636004443 ligand binding site [chemical binding]; other site 286636004444 sodium binding site [ion binding]; other site 286636004445 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 286636004446 putative RNA binding site [nucleotide binding]; other site 286636004447 Asp23 family; Region: Asp23; cl00574 286636004448 elongation factor P; Validated; Region: PRK00529 286636004449 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 286636004450 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 286636004451 RNA binding site [nucleotide binding]; other site 286636004452 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 286636004453 RNA binding site [nucleotide binding]; other site 286636004454 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 286636004455 catalytic motif [active] 286636004456 Zn binding site [ion binding]; other site 286636004457 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 286636004458 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 286636004459 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 286636004460 active site 286636004461 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 286636004462 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 286636004463 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 286636004464 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 286636004465 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 286636004466 CsbD-like; Region: CsbD; cl15799 286636004467 Abi-like protein; Region: Abi_2; cl01988 286636004468 NlpC/P60 family; Region: NLPC_P60; cl11438 286636004469 Bacterial SH3 domain; Region: SH3_3; cl02551 286636004470 Bacteriophage holin; Region: Phage_holin_1; cl02344 286636004471 Protein of unknown function (DUF1617); Region: DUF1617; pfam07761 286636004472 gp58-like protein; Region: Gp58; pfam07902 286636004473 Hyaluronidase protein (HylP); Region: Hyaluronidase_1; pfam07212 286636004474 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 286636004475 Protein-interacting V-domain of mammalian Alix and related domains; Region: V_Alix_like; cl14654 286636004476 putative YPXnL-motif binding site; other site 286636004477 Phage-related protein [Function unknown]; Region: COG4722; cl15832 286636004478 Phage tail protein; Region: Sipho_tail; pfam05709 286636004479 tape measure domain; Region: tape_meas_nterm; TIGR02675 286636004480 Phage-related protein [Function unknown]; Region: COG5412 286636004481 Phage protein; Region: DUF3647; cl10335 286636004482 Phage major tail protein 2; Region: Phage_tail_2; cl11463 286636004483 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 286636004484 active site 286636004485 conformational flexibility of ligand binding pocket; other site 286636004486 ADP-ribosylating toxin turn-turn motif; other site 286636004487 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 286636004488 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 286636004489 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 286636004490 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 286636004491 Phage terminase large subunit; Region: Terminase_3; cl12054 286636004492 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 286636004493 DNA binding site [nucleotide binding] 286636004494 active site 286636004495 Int/Topo IB signature motif; other site 286636004496 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 286636004497 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 286636004498 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 286636004499 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 286636004500 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 286636004501 dimer interface [polypeptide binding]; other site 286636004502 ssDNA binding site [nucleotide binding]; other site 286636004503 tetramer (dimer of dimers) interface [polypeptide binding]; other site 286636004504 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 286636004505 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 286636004506 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 286636004507 minor groove reading motif; other site 286636004508 helix-hairpin-helix signature motif; other site 286636004509 substrate binding pocket [chemical binding]; other site 286636004510 active site 286636004511 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 286636004512 DNA binding and oxoG recognition site [nucleotide binding] 286636004513 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 286636004514 catalytic residues [active] 286636004515 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 286636004516 active site 286636004517 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 286636004518 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 286636004519 Walker A/P-loop; other site 286636004520 ATP binding site [chemical binding]; other site 286636004521 Q-loop/lid; other site 286636004522 ABC transporter signature motif; other site 286636004523 Walker B; other site 286636004524 D-loop; other site 286636004525 H-loop/switch region; other site 286636004526 Smr domain; Region: Smr; cl02619 286636004527 Colicin V production protein; Region: Colicin_V; cl00567 286636004528 ribonuclease HIII; Provisional; Region: PRK00996 286636004529 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 286636004530 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 286636004531 RNA/DNA hybrid binding site [nucleotide binding]; other site 286636004532 active site 286636004533 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 286636004534 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 286636004535 Catalytic site [active] 286636004536 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 286636004537 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 286636004538 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 286636004539 DNA binding site [nucleotide binding] 286636004540 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 286636004541 Family description; Region: UvrD_C_2; cl15862 286636004542 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 286636004543 active site 286636004544 DNA polymerase IV; Validated; Region: PRK02406 286636004545 DNA binding site [nucleotide binding] 286636004546 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 286636004547 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 286636004548 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 286636004549 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 286636004550 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 286636004551 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 286636004552 amphipathic channel; other site 286636004553 Asn-Pro-Ala signature motifs; other site 286636004554 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 286636004555 putative substrate translocation pore; other site 286636004556 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 286636004557 Helix-turn-helix domains; Region: HTH; cl00088 286636004558 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 286636004559 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; cl07696 286636004560 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 286636004561 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 286636004562 non-specific DNA binding site [nucleotide binding]; other site 286636004563 salt bridge; other site 286636004564 sequence-specific DNA binding site [nucleotide binding]; other site 286636004565 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 286636004566 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 286636004567 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 286636004568 Sodium:solute symporter family; Region: SSF; cl00456 286636004569 general secretory pathway protein E; Region: type_II_gspE; TIGR02533 286636004570 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 286636004571 DNA binding residues [nucleotide binding] 286636004572 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 286636004573 active site 286636004574 substrate binding site [chemical binding]; other site 286636004575 catalytic site [active] 286636004576 Helix-turn-helix domains; Region: HTH; cl00088 286636004577 Predicted flavoproteins [General function prediction only]; Region: COG2081 286636004578 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636004579 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 286636004580 intersubunit interface [polypeptide binding]; other site 286636004581 active site 286636004582 catalytic residue [active] 286636004583 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 286636004584 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 286636004585 Nucleoside recognition; Region: Gate; cl00486 286636004586 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 286636004587 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 286636004588 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 286636004589 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 286636004590 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 286636004591 DNA-binding site [nucleotide binding]; DNA binding site 286636004592 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 286636004593 UGMP family protein; Validated; Region: PRK09604 286636004594 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 286636004595 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 286636004596 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 286636004597 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 286636004598 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 286636004599 Glycoprotease family; Region: Peptidase_M22; pfam00814 286636004600 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 286636004601 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 286636004602 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 286636004603 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 286636004604 glutamine synthetase, type I; Region: GlnA; TIGR00653 286636004605 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 286636004606 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 286636004607 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 286636004608 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 286636004609 DNA binding residues [nucleotide binding] 286636004610 putative dimer interface [polypeptide binding]; other site 286636004611 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 286636004612 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 286636004613 Phosphoglycerate kinase; Region: PGK; pfam00162 286636004614 substrate binding site [chemical binding]; other site 286636004615 hinge regions; other site 286636004616 ADP binding site [chemical binding]; other site 286636004617 catalytic site [active] 286636004618 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 286636004619 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 286636004620 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 286636004621 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 286636004622 DAK2 domain; Region: Dak2; cl03685 286636004623 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 286636004624 Asp23 family; Region: Asp23; cl00574 286636004625 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 286636004626 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 286636004627 hypothetical protein; Provisional; Region: PRK08185 286636004628 intersubunit interface [polypeptide binding]; other site 286636004629 active site 286636004630 zinc binding site [ion binding]; other site 286636004631 Na+ binding site [ion binding]; other site 286636004632 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 286636004633 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 286636004634 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 286636004635 CTP synthetase; Validated; Region: pyrG; PRK05380 286636004636 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 286636004637 Catalytic site [active] 286636004638 active site 286636004639 UTP binding site [chemical binding]; other site 286636004640 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 286636004641 active site 286636004642 putative oxyanion hole; other site 286636004643 catalytic triad [active] 286636004644 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 286636004645 trigger factor; Provisional; Region: tig; PRK01490 286636004646 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 286636004647 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 286636004648 Mechanosensitive ion channel; Region: MS_channel; pfam00924 286636004649 Protein of unknown function (DUF436); Region: DUF436; cl01860 286636004650 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 286636004651 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 286636004652 substrate binding site [chemical binding]; other site 286636004653 dimer interface [polypeptide binding]; other site 286636004654 ATP binding site [chemical binding]; other site 286636004655 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 286636004656 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 286636004657 dimerization interface 3.5A [polypeptide binding]; other site 286636004658 active site 286636004659 Glycerate kinase family; Region: Gly_kinase; cl00841 286636004660 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 286636004661 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 286636004662 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 286636004663 ATP binding site [chemical binding]; other site 286636004664 putative Mg++ binding site [ion binding]; other site 286636004665 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 286636004666 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 286636004667 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 286636004668 HsdM N-terminal domain; Region: HsdM_N; pfam12161 286636004669 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 286636004670 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636004671 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 286636004672 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 286636004673 active site 286636004674 phosphorylation site [posttranslational modification] 286636004675 intermolecular recognition site; other site 286636004676 dimerization interface [polypeptide binding]; other site 286636004677 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 286636004678 DNA binding residues [nucleotide binding] 286636004679 dimerization interface [polypeptide binding]; other site 286636004680 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 286636004681 FtsX-like permease family; Region: FtsX; cl15850 286636004682 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 286636004683 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 286636004684 Walker A/P-loop; other site 286636004685 ATP binding site [chemical binding]; other site 286636004686 Q-loop/lid; other site 286636004687 ABC transporter signature motif; other site 286636004688 Walker B; other site 286636004689 D-loop; other site 286636004690 H-loop/switch region; other site 286636004691 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 286636004692 ABC transporter signature motif; other site 286636004693 Walker B; other site 286636004694 D-loop; other site 286636004695 H-loop/switch region; other site 286636004696 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 286636004697 Type-A lantibiotic; Region: L_biotic_typeA; pfam04604 286636004698 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 286636004699 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 286636004700 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 286636004701 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 286636004702 P-loop; other site 286636004703 active site 286636004704 phosphorylation site [posttranslational modification] 286636004705 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 286636004706 methionine cluster; other site 286636004707 active site 286636004708 phosphorylation site [posttranslational modification] 286636004709 metal binding site [ion binding]; metal-binding site 286636004710 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 286636004711 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 286636004712 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 286636004713 putative substrate binding site [chemical binding]; other site 286636004714 putative ATP binding site [chemical binding]; other site 286636004715 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 286636004716 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 286636004717 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 286636004718 Helix-turn-helix domains; Region: HTH; cl00088 286636004719 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 286636004720 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 286636004721 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 286636004722 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 286636004723 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 286636004724 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 286636004725 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 286636004726 23S rRNA interface [nucleotide binding]; other site 286636004727 L3 interface [polypeptide binding]; other site 286636004728 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 286636004729 non-specific DNA binding site [nucleotide binding]; other site 286636004730 salt bridge; other site 286636004731 sequence-specific DNA binding site [nucleotide binding]; other site 286636004732 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 286636004733 YacP-like NYN domain; Region: NYN_YacP; cl01491 286636004734 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 286636004735 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 286636004736 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 286636004737 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 286636004738 active site 286636004739 metal binding site [ion binding]; metal-binding site 286636004740 dimerization interface [polypeptide binding]; other site 286636004741 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 286636004742 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 286636004743 active site 286636004744 HIGH motif; other site 286636004745 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 286636004746 KMSKS motif; other site 286636004747 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 286636004748 tRNA binding surface [nucleotide binding]; other site 286636004749 anticodon binding site; other site 286636004750 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 286636004751 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 286636004752 trimer interface [polypeptide binding]; other site 286636004753 active site 286636004754 substrate binding site [chemical binding]; other site 286636004755 CoA binding site [chemical binding]; other site 286636004756 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 286636004757 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 286636004758 RNase E interface [polypeptide binding]; other site 286636004759 trimer interface [polypeptide binding]; other site 286636004760 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 286636004761 RNase E interface [polypeptide binding]; other site 286636004762 trimer interface [polypeptide binding]; other site 286636004763 active site 286636004764 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 286636004765 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 286636004766 RNA binding site [nucleotide binding]; other site 286636004767 domain interface; other site 286636004768 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 286636004769 active site 286636004770 intersubunit interactions; other site 286636004771 catalytic residue [active] 286636004772 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 286636004773 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 286636004774 P-loop; other site 286636004775 active site 286636004776 phosphorylation site [posttranslational modification] 286636004777 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 286636004778 PRD domain; Region: PRD; cl15445 286636004779 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 286636004780 P-loop; other site 286636004781 active site 286636004782 phosphorylation site [posttranslational modification] 286636004783 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 286636004784 active site 286636004785 phosphorylation site [posttranslational modification] 286636004786 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 286636004787 16S/18S rRNA binding site [nucleotide binding]; other site 286636004788 S13e-L30e interaction site [polypeptide binding]; other site 286636004789 25S rRNA binding site [nucleotide binding]; other site 286636004790 Helix-turn-helix domains; Region: HTH; cl00088 286636004791 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 286636004792 active site 286636004793 catalytic residues [active] 286636004794 metal binding site [ion binding]; metal-binding site 286636004795 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 286636004796 Helix-turn-helix domains; Region: HTH; cl00088 286636004797 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 286636004798 DNA polymerase III PolC; Validated; Region: polC; PRK00448 286636004799 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 286636004800 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 286636004801 generic binding surface II; other site 286636004802 generic binding surface I; other site 286636004803 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 286636004804 active site 286636004805 substrate binding site [chemical binding]; other site 286636004806 catalytic site [active] 286636004807 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 286636004808 prolyl-tRNA synthetase; Provisional; Region: PRK09194 286636004809 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 286636004810 dimer interface [polypeptide binding]; other site 286636004811 motif 1; other site 286636004812 active site 286636004813 motif 2; other site 286636004814 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 286636004815 putative deacylase active site [active] 286636004816 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 286636004817 active site 286636004818 motif 3; other site 286636004819 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 286636004820 anticodon binding site; other site 286636004821 RIP metalloprotease RseP; Region: TIGR00054 286636004822 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 286636004823 active site 286636004824 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 286636004825 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 286636004826 putative substrate binding region [chemical binding]; other site 286636004827 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 286636004828 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 286636004829 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 286636004830 catalytic residue [active] 286636004831 putative FPP diphosphate binding site; other site 286636004832 putative FPP binding hydrophobic cleft; other site 286636004833 dimer interface [polypeptide binding]; other site 286636004834 putative IPP diphosphate binding site; other site 286636004835 Preprotein translocase subunit; Region: YajC; cl00806 286636004836 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 286636004837 catalytic residues [active] 286636004838 pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102 286636004839 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 286636004840 carbohydrate binding site [chemical binding]; other site 286636004841 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 286636004842 carbohydrate binding site [chemical binding]; other site 286636004843 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 286636004844 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 286636004845 Ca binding site [ion binding]; other site 286636004846 active site 286636004847 catalytic site [active] 286636004848 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 286636004849 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 286636004850 Ca binding site [ion binding]; other site 286636004851 active site 286636004852 catalytic site [active] 286636004853 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 286636004854 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 286636004855 Walker A/P-loop; other site 286636004856 ATP binding site [chemical binding]; other site 286636004857 Q-loop/lid; other site 286636004858 ABC transporter signature motif; other site 286636004859 Walker B; other site 286636004860 D-loop; other site 286636004861 H-loop/switch region; other site 286636004862 TOBE domain; Region: TOBE_2; cl01440 286636004863 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 286636004864 Helix-turn-helix domains; Region: HTH; cl00088 286636004865 Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821 286636004866 Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821 286636004867 Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821 286636004868 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 286636004869 putative active site [active] 286636004870 dimerization interface [polypeptide binding]; other site 286636004871 putative tRNAtyr binding site [nucleotide binding]; other site 286636004872 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 286636004873 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 286636004874 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 286636004875 synthetase active site [active] 286636004876 NTP binding site [chemical binding]; other site 286636004877 metal binding site [ion binding]; metal-binding site 286636004878 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 286636004879 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 286636004880 dihydrolipoamide succinyltransferase; Provisional; Region: PTZ00144 286636004881 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 286636004882 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 286636004883 putative catalytic site [active] 286636004884 putative metal binding site [ion binding]; other site 286636004885 putative phosphate binding site [ion binding]; other site 286636004886 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 286636004887 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 286636004888 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 286636004889 active site turn [active] 286636004890 phosphorylation site [posttranslational modification] 286636004891 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 286636004892 HPr interaction site; other site 286636004893 glycerol kinase (GK) interaction site [polypeptide binding]; other site 286636004894 active site 286636004895 phosphorylation site [posttranslational modification] 286636004896 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 286636004897 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 286636004898 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 286636004899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 286636004900 S-adenosylmethionine binding site [chemical binding]; other site 286636004901 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 286636004902 amidase; Provisional; Region: PRK06529 286636004903 Amidase; Region: Amidase; cl11426 286636004904 aminodeoxychorismate synthase; Provisional; Region: PRK07508 286636004905 chorismate binding enzyme; Region: Chorismate_bind; cl10555 286636004906 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 286636004907 substrate-cofactor binding pocket; other site 286636004908 pyridoxal 5'-phosphate binding site [chemical binding]; other site 286636004909 catalytic residue [active] 286636004910 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 286636004911 Glutamine amidotransferase class-I; Region: GATase; pfam00117 286636004912 glutamine binding [chemical binding]; other site 286636004913 catalytic triad [active] 286636004914 recombination factor protein RarA; Reviewed; Region: PRK13342 286636004915 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 286636004916 Walker A motif; other site 286636004917 ATP binding site [chemical binding]; other site 286636004918 Walker B motif; other site 286636004919 arginine finger; other site 286636004920 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 286636004921 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 286636004922 Coenzyme A binding pocket [chemical binding]; other site 286636004923 topology modulation protein; Provisional; Region: PRK07261 286636004924 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 286636004925 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 286636004926 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 286636004927 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 286636004928 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 286636004929 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 286636004930 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 286636004931 dimer interface [polypeptide binding]; other site 286636004932 conserved gate region; other site 286636004933 putative PBP binding loops; other site 286636004934 ABC-ATPase subunit interface; other site 286636004935 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 286636004936 dimer interface [polypeptide binding]; other site 286636004937 conserved gate region; other site 286636004938 putative PBP binding loops; other site 286636004939 ABC-ATPase subunit interface; other site 286636004940 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 286636004941 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 286636004942 Walker A/P-loop; other site 286636004943 ATP binding site [chemical binding]; other site 286636004944 Q-loop/lid; other site 286636004945 ABC transporter signature motif; other site 286636004946 Walker B; other site 286636004947 D-loop; other site 286636004948 H-loop/switch region; other site 286636004949 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 286636004950 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 286636004951 Walker A/P-loop; other site 286636004952 ATP binding site [chemical binding]; other site 286636004953 Q-loop/lid; other site 286636004954 ABC transporter signature motif; other site 286636004955 Walker B; other site 286636004956 D-loop; other site 286636004957 H-loop/switch region; other site 286636004958 CsbD-like; Region: CsbD; cl15799 286636004959 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 286636004960 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 286636004961 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 286636004962 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 286636004963 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 286636004964 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 286636004965 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 286636004966 metal binding site [ion binding]; metal-binding site 286636004967 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 286636004968 putative active site [active] 286636004969 catalytic triad [active] 286636004970 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 286636004971 PA/protease domain interface [polypeptide binding]; other site 286636004972 putative integrin binding motif; other site 286636004973 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 286636004974 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 286636004975 FlgD Ig-like domain; Region: FlgD_ig; cl15790 286636004976 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 286636004977 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 286636004978 Helix-turn-helix domains; Region: HTH; cl00088 286636004979 Helix-turn-helix domains; Region: HTH; cl00088 286636004980 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 286636004981 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 286636004982 Surface antigen [General function prediction only]; Region: COG3942 286636004983 NlpC/P60 family; Region: NLPC_P60; cl11438 286636004984 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 286636004985 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 286636004986 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 286636004987 dimer interface [polypeptide binding]; other site 286636004988 phosphorylation site [posttranslational modification] 286636004989 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 286636004990 ATP binding site [chemical binding]; other site 286636004991 Mg2+ binding site [ion binding]; other site 286636004992 G-X-G motif; other site 286636004993 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 286636004994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 286636004995 active site 286636004996 phosphorylation site [posttranslational modification] 286636004997 intermolecular recognition site; other site 286636004998 dimerization interface [polypeptide binding]; other site 286636004999 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 286636005000 DNA binding site [nucleotide binding] 286636005001 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 286636005002 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 286636005003 FtsX-like permease family; Region: FtsX; cl15850 286636005004 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 286636005005 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 286636005006 Walker A/P-loop; other site 286636005007 ATP binding site [chemical binding]; other site 286636005008 Q-loop/lid; other site 286636005009 ABC transporter signature motif; other site 286636005010 Walker B; other site 286636005011 D-loop; other site 286636005012 H-loop/switch region; other site 286636005013 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 286636005014 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 286636005015 Domain of unknown function (DUF4298); Region: DUF4298; pfam14131 286636005016 foldase protein PrsA; Reviewed; Region: PRK12450 286636005017 Peptidase C10 family; Region: Peptidase_C10; pfam01640 286636005018 Peptidase C10 family; Region: Peptidase_C10; pfam01640 286636005019 Helix-turn-helix domains; Region: HTH; cl00088 286636005020 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 286636005021 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 286636005022 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 286636005023 tetramer interfaces [polypeptide binding]; other site 286636005024 binuclear metal-binding site [ion binding]; other site 286636005025 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 286636005026 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 286636005027 dimer interface [polypeptide binding]; other site 286636005028 active site 286636005029 metal binding site [ion binding]; metal-binding site 286636005030 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 286636005031 active site 286636005032 intersubunit interactions; other site 286636005033 catalytic residue [active] 286636005034 pyruvate formate-lyase; Region: PFL2-3; TIGR01774 286636005035 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 286636005036 dimer interface [polypeptide binding]; other site 286636005037 active site 286636005038 glycine loop; other site 286636005039 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 286636005040 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 286636005041 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 286636005042 active site 286636005043 P-loop; other site 286636005044 phosphorylation site [posttranslational modification] 286636005045 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 286636005046 active site 286636005047 methionine cluster; other site 286636005048 phosphorylation site [posttranslational modification] 286636005049 metal binding site [ion binding]; metal-binding site 286636005050 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 286636005051 Helix-turn-helix domains; Region: HTH; cl00088 286636005052 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 286636005053 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 286636005054 Helix-turn-helix domains; Region: HTH; cl00088 286636005055 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 286636005056 active site 286636005057 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 286636005058 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 286636005059 FeS/SAM binding site; other site 286636005060 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 286636005061 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 286636005062 Transglycosylase; Region: Transgly; cl07896 286636005063 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 286636005064 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 286636005065 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 286636005066 homotrimer interaction site [polypeptide binding]; other site 286636005067 putative active site [active] 286636005068 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 286636005069 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 286636005070 active site 286636005071 Predicted membrane protein [Function unknown]; Region: COG4640 286636005072 Peptidase family C69; Region: Peptidase_C69; pfam03577 286636005073 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 286636005074 non-specific DNA binding site [nucleotide binding]; other site 286636005075 salt bridge; other site 286636005076 sequence-specific DNA binding site [nucleotide binding]; other site 286636005077 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 286636005078 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 286636005079 ring oligomerisation interface [polypeptide binding]; other site 286636005080 ATP/Mg binding site [chemical binding]; other site 286636005081 stacking interactions; other site 286636005082 hinge regions; other site 286636005083 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 286636005084 oligomerisation interface [polypeptide binding]; other site 286636005085 mobile loop; other site 286636005086 roof hairpin; other site 286636005087 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 286636005088 Clp amino terminal domain; Region: Clp_N; pfam02861 286636005089 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 286636005090 Walker A motif; other site 286636005091 ATP binding site [chemical binding]; other site 286636005092 Walker B motif; other site 286636005093 arginine finger; other site 286636005094 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 286636005095 Walker A motif; other site 286636005096 ATP binding site [chemical binding]; other site 286636005097 Walker B motif; other site 286636005098 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 286636005099 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 286636005100 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 286636005101 DNA-binding site [nucleotide binding]; DNA binding site 286636005102 RNA-binding motif; other site 286636005103 peroxiredoxin; Region: AhpC; TIGR03137 286636005104 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 286636005105 dimer interface [polypeptide binding]; other site 286636005106 decamer (pentamer of dimers) interface [polypeptide binding]; other site 286636005107 catalytic triad [active] 286636005108 peroxidatic and resolving cysteines [active] 286636005109 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 286636005110 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 286636005111 catalytic residue [active] 286636005112 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 286636005113 catalytic residues [active] 286636005114 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636005115 imidazolonepropionase; Validated; Region: PRK09356 286636005116 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 286636005117 active site 286636005118 urocanate hydratase; Provisional; Region: PRK05414 286636005119 Glutamate formiminotransferase [Amino acid transport and metabolism]; Region: COG3643 286636005120 Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837 286636005121 Formiminotransferase domain; Region: FTCD; pfam02971 286636005122 Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350 286636005123 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 286636005124 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 286636005125 Potassium binding sites [ion binding]; other site 286636005126 Cesium cation binding sites [ion binding]; other site 286636005127 HutD; Region: HutD; cl01532 286636005128 amino acid transporter; Region: 2A0306; TIGR00909 286636005129 Spore germination protein; Region: Spore_permease; cl15802 286636005130 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 286636005131 active sites [active] 286636005132 tetramer interface [polypeptide binding]; other site 286636005133 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 286636005134 Arginase family; Region: Arginase; cl00306 286636005135 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 286636005136 Predicted ATPase [General function prediction only]; Region: COG3899 286636005137 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 286636005138 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 286636005139 Helix-turn-helix domains; Region: HTH; cl00088 286636005140 Integrase core domain; Region: rve; cl01316 286636005141 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 286636005142 rRNA interaction site [nucleotide binding]; other site 286636005143 S8 interaction site; other site 286636005144 putative laminin-1 binding site; other site 286636005145 elongation factor Ts; Provisional; Region: tsf; PRK09377 286636005146 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 286636005147 Elongation factor TS; Region: EF_TS; pfam00889 286636005148 Elongation factor TS; Region: EF_TS; pfam00889 286636005149 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 286636005150 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 286636005151 active site 286636005152 Zn binding site [ion binding]; other site 286636005153 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 286636005154 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 286636005155 Ca binding site [ion binding]; other site 286636005156 active site 286636005157 catalytic site [active] 286636005158 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 286636005159 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 286636005160 active site turn [active] 286636005161 phosphorylation site [posttranslational modification] 286636005162 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 286636005163 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 286636005164 HPr interaction site; other site 286636005165 glycerol kinase (GK) interaction site [polypeptide binding]; other site 286636005166 active site 286636005167 phosphorylation site [posttranslational modification] 286636005168 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 286636005169 DNA-binding site [nucleotide binding]; DNA binding site 286636005170 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 286636005171 UTRA domain; Region: UTRA; cl01230 286636005172 Helix-turn-helix domains; Region: HTH; cl00088 286636005173 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 286636005174 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 286636005175 putative metal binding site [ion binding]; other site 286636005176 Protein of unknown function (DUF328); Region: DUF328; cl01143 286636005177 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 286636005178 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 286636005179 FeS/SAM binding site; other site 286636005180 Predicted acetyltransferase [General function prediction only]; Region: COG3981 286636005181 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 286636005182 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 286636005183 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636005184 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 286636005185 ATP cone domain; Region: ATP-cone; pfam03477 286636005186 Class III ribonucleotide reductase; Region: RNR_III; cd01675 286636005187 effector binding site; other site 286636005188 active site 286636005189 Zn binding site [ion binding]; other site 286636005190 glycine loop; other site 286636005191 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 286636005192 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 286636005193 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 286636005194 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 286636005195 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 286636005196 ArsC family; Region: ArsC; pfam03960 286636005197 putative catalytic residues [active] 286636005198 thiol/disulfide switch; other site 286636005199 recombinase A; Provisional; Region: recA; PRK09354 286636005200 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 286636005201 hexamer interface [polypeptide binding]; other site 286636005202 Walker A motif; other site 286636005203 ATP binding site [chemical binding]; other site 286636005204 Walker B motif; other site 286636005205 competence damage-inducible protein A; Provisional; Region: PRK00549 286636005206 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 286636005207 putative MPT binding site; other site 286636005208 Competence-damaged protein; Region: CinA; cl00666 286636005209 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 286636005210 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 286636005211 RuvA N terminal domain; Region: RuvA_N; pfam01330 286636005212 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 286636005213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 286636005214 putative substrate translocation pore; other site 286636005215 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 286636005216 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 286636005217 ATP binding site [chemical binding]; other site 286636005218 Mg2+ binding site [ion binding]; other site 286636005219 G-X-G motif; other site 286636005220 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 286636005221 ATP binding site [chemical binding]; other site 286636005222 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 286636005223 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 286636005224 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 286636005225 Int/Topo IB signature motif; other site 286636005226 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 286636005227 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 286636005228 Prophage antirepressor [Transcription]; Region: COG3617 286636005229 BRO family, N-terminal domain; Region: Bro-N; cl10591 286636005230 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 286636005231 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 286636005232 Phage associated DNA primase [General function prediction only]; Region: COG3378 286636005233 D5 N terminal like; Region: D5_N; cl07360 286636005234 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 286636005235 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 286636005236 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 286636005237 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 286636005238 MutS domain I; Region: MutS_I; pfam01624 286636005239 MutS domain II; Region: MutS_II; pfam05188 286636005240 MutS family domain IV; Region: MutS_IV; pfam05190 286636005241 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 286636005242 Walker A/P-loop; other site 286636005243 ATP binding site [chemical binding]; other site 286636005244 Q-loop/lid; other site 286636005245 ABC transporter signature motif; other site 286636005246 Walker B; other site 286636005247 D-loop; other site 286636005248 H-loop/switch region; other site 286636005249 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 286636005250 arginine repressor; Region: argR_whole; TIGR01529 286636005251 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 286636005252 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 286636005253 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 286636005254 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 286636005255 active site 286636005256 HIGH motif; other site 286636005257 KMSK motif region; other site 286636005258 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 286636005259 tRNA binding surface [nucleotide binding]; other site 286636005260 anticodon binding site; other site 286636005261 Enterocin A Immunity; Region: EntA_Immun; pfam08951 286636005262 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 286636005263 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 286636005264 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 286636005265 Uncharacterized conserved protein [Function unknown]; Region: COG1284 286636005266 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 286636005267 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 286636005268 Uncharacterized conserved protein [Function unknown]; Region: COG1284 286636005269 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 286636005270 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 286636005271 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 286636005272 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 286636005273 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 286636005274 dimer interface [polypeptide binding]; other site 286636005275 anticodon binding site; other site 286636005276 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 286636005277 homodimer interface [polypeptide binding]; other site 286636005278 motif 1; other site 286636005279 active site 286636005280 motif 2; other site 286636005281 GAD domain; Region: GAD; pfam02938 286636005282 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 286636005283 motif 3; other site 286636005284 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 286636005285 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 286636005286 dimer interface [polypeptide binding]; other site 286636005287 motif 1; other site 286636005288 active site 286636005289 motif 2; other site 286636005290 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 286636005291 anticodon binding site; other site 286636005292 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 286636005293 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 286636005294 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 286636005295 Cadmium resistance transporter; Region: Cad; cl04177 286636005296 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 286636005297 putative DNA binding site [nucleotide binding]; other site 286636005298 putative Zn2+ binding site [ion binding]; other site 286636005299 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 286636005300 Chloroplast import component protein (Tic20); Region: Tic20; cl09892 286636005301 Domain of unknown function (DUF368); Region: DUF368; cl00893 286636005302 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 286636005303 Helix-turn-helix domains; Region: HTH; cl00088 286636005304 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 286636005305 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 286636005306 Predicted membrane protein [Function unknown]; Region: COG1511 286636005307 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 286636005308 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 286636005309 ABC-2 type transporter; Region: ABC2_membrane; cl11417 286636005310 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 286636005311 Helix-turn-helix domains; Region: HTH; cl00088 286636005312 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 286636005313 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 286636005314 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 286636005315 RNA binding surface [nucleotide binding]; other site 286636005316 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 286636005317 replicative DNA helicase; Provisional; Region: PRK05748 286636005318 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 286636005319 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 286636005320 Walker A motif; other site 286636005321 ATP binding site [chemical binding]; other site 286636005322 Walker B motif; other site 286636005323 DNA binding loops [nucleotide binding] 286636005324 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 286636005325 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 286636005326 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 286636005327 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 286636005328 DHH family; Region: DHH; pfam01368 286636005329 DHHA1 domain; Region: DHHA1; pfam02272 286636005330 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 286636005331 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636005332 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 286636005333 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 286636005334 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 286636005335 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 286636005336 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 286636005337 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 286636005338 putative L-serine binding site [chemical binding]; other site 286636005339 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 286636005340 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 286636005341 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 286636005342 Cobalt transport protein; Region: CbiQ; cl00463 286636005343 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649 286636005344 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 286636005345 Walker A/P-loop; other site 286636005346 ATP binding site [chemical binding]; other site 286636005347 Q-loop/lid; other site 286636005348 ABC transporter signature motif; other site 286636005349 Walker B; other site 286636005350 D-loop; other site 286636005351 H-loop/switch region; other site 286636005352 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650 286636005353 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 286636005354 Walker A/P-loop; other site 286636005355 ATP binding site [chemical binding]; other site 286636005356 Q-loop/lid; other site 286636005357 ABC transporter signature motif; other site 286636005358 Walker B; other site 286636005359 D-loop; other site 286636005360 H-loop/switch region; other site 286636005361 Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370 286636005362 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 286636005363 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 286636005364 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 286636005365 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 286636005366 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 286636005367 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 286636005368 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 286636005369 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 286636005370 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 286636005371 Helix-turn-helix domains; Region: HTH; cl00088 286636005372 Integrase core domain; Region: rve; cl01316 286636005373 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 286636005374 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 286636005375 DXD motif; other site 286636005376 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 286636005377 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 286636005378 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 286636005379 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 286636005380 active site 286636005381 tetramer interface; other site 286636005382 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 286636005383 recF protein; Region: recf; TIGR00611 286636005384 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 286636005385 Walker A/P-loop; other site 286636005386 ATP binding site [chemical binding]; other site 286636005387 Q-loop/lid; other site 286636005388 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 286636005389 ABC transporter signature motif; other site 286636005390 Walker B; other site 286636005391 D-loop; other site 286636005392 H-loop/switch region; other site 286636005393 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 286636005394 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 286636005395 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 286636005396 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 286636005397 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 286636005398 active site 286636005399 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 286636005400 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 286636005401 active site 286636005402 HIGH motif; other site 286636005403 dimer interface [polypeptide binding]; other site 286636005404 KMSKS motif; other site 286636005405 Uncharacterized conserved protein [Function unknown]; Region: COG1284 286636005406 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 286636005407 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 286636005408 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 286636005409 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 286636005410 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 286636005411 Walker A/P-loop; other site 286636005412 ATP binding site [chemical binding]; other site 286636005413 Q-loop/lid; other site 286636005414 ABC transporter signature motif; other site 286636005415 Walker B; other site 286636005416 D-loop; other site 286636005417 H-loop/switch region; other site 286636005418 ABC transporter; Region: ABC_tran_2; pfam12848 286636005419 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 286636005420 Predicted membrane protein [Function unknown]; Region: COG4485 286636005421 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 286636005422 Helix-turn-helix domains; Region: HTH; cl00088 286636005423 Integrase core domain; Region: rve; cl01316 286636005424 Integrase core domain; Region: rve; cl01316 286636005425 Helix-turn-helix domains; Region: HTH; cl00088 286636005426 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 286636005427 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 286636005428 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 286636005429 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 286636005430 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 286636005431 protein binding site [polypeptide binding]; other site 286636005432 ParB-like partition proteins; Region: parB_part; TIGR00180 286636005433 ParB-like nuclease domain; Region: ParBc; cl02129 286636005434 Helix-turn-helix domains; Region: HTH; cl00088